Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 93, No. 2 (Jan. 23, 1996), pp. i-viiPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/38499 .
Accessed: 07/05/2014 21:23
Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at .http://www.jstor.org/page/info/about/policies/terms.jsp
.JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range ofcontent in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new formsof scholarship. For more information about JSTOR, please contact [email protected].
.
National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access toProceedings of the National Academy of Sciences of the United States of America.
http://www.jstor.org
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 21:23:34 PMAll use subject to JSTOR Terms and Conditions
PROCEEDINGS OF THE
NATIONAL ACADEMY OF SCIENCES
OF THE UNITED STATES OF AMERICA
January23, 1996 Volume 93/ Number 2
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 21:23:34 PMAll use subject to JSTOR Terms and Conditions
PROCEEDINGS OF THE
NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Officers of the Academy
BRUCE ALBERTS, President JACK HALPERN, Vice President PETER H. RAVEN, Home Secretary F. SHERWOOD ROWLAND, Foreign Secretary MILDRED S. DRESSELHAUS, Treasurer
Editor-in-Chief NICHOLAS R. COZZARELLI
Editorial Board of the Proceedings
PETER J. BICKEL MICHAEL T. CLEGG MARSHIALL H. COHEN MAX D. COOPER JAMES E. DARNELL, JR. IGOR B. DAWID HERMAN N. EISEN RAYMOND L. ERIKSON RONALD M. EVANS NINA FEDOROFF CHARLES FEFFERMAN
JOSEPH L. GOLDSTEIN JACK HALPERN ERIC R. KANDEL RICHARD A. LERNER PHIL W. MAJERUS ARNO G. MOTULSKY RONALD L. PHILLIPS STANLEY B. PRUSINER CHIARLES RADDING GIAN-CARLO ROTA DAVID D. SABATINI
PAUL R. SCHIMMEL STUART L. SCHREIBER CARLA J. SHATZ PAUL B. SIGLER ALLAN C. SPRADLING CHARLES F. STEVENS JOANNE STUBBE KARL TUREKIAN IRVING L. WEISSMAN SHERMAN M. WEISSMAN PETER G. WOLYNES
Publisher: KENNETH R. FULTON Managing Editor: FRANCES R. ZWANZIG Senior Associate Editor: GARY T. COCKS Associate Editors: CAY BUTLER, REID S. COMPTON, JOHN M. MALLOY, MARILYN J. MASON, T. PEARSON,
JANET MORGAN Ross, DOROTHY P. SMITH, COLENE RUCH WALDEN Associate Managing Editor: JOANNE D'AMICo Senior Production Editor: BARBARA A. BACON Production Editors: JAMIE M. FEAR, BILL FOGLE, ELLEN GOLDBERG, SCOTT C. HERMAN, AIJA OZOLINS,
KATHLEEN RUBY, ANNE M. SUNDERMANN, DON C. TIPPMAN Proofreader: MARY E. MCLAUGHLIN Administrative Assistants: DELORES BANKS, BRENDA L. McCoY Manuscript Coordinators: DONNA M. LIVINGSTON, DOTTIE MAY, JACQUELINE PERRY Circulation: JULIA LITTLE, CYNTHIA MATHEWS
Correspondence: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, NW, Washington, DC 20418 (via U.S. postal service) or 1010 Wisconsin Avenue, NW, Suite 530, Washington, DC 20007 (via courier service).
Information for Contributors: See pp. i and ii (of this issue).
Copyright: Volumes 90-93, copyright C 1993-1996 by the National Academy of Sciences; Volumes 1-89, copyright as a collective work only with copyright to individual articles retained by the author(s). Requests for permission to reproduce all or parts of individual articles published in Volumes 1-89 should be addressed to the authors. Microforms of complete volumes are available to regular subscribers only and may be obtained from University Microfilms, Xerox Corporation, Ann Arbor, MI 48103. This journal is printed on acid-free paper effective with Volume 84, Issue 1.
Subscriptions: All correspondence concerning subscriptions should be addressed to the Circulation Office of the PROCEEDINGS. Subscriptions are entered on a calendar year basis only. For 1996, subscription rates are as follows-in the United States: personal, $250; institutional, $595; elsewhere by surface mail: personal, $350; institutional, $695; elsewhere by Air Cargo at a surcharge of $208. Information regarding other air mail postage rates is available from the Circulation Office. Subscribers are requested to notify the Circulation Office of the PROCEEDINGS 6 weeks in advance of any change of address; also the local postmaster. The Academy is not responsible for nonreceipt of issues because of an improper address unless a change of address is on file. The notice of address change should list both the old and new addresses. Claims for replacement copies will not be honored more than 60 days after the issue date for domestic subscribers and not more than 90 days after the issue date for foreign subscribers.
Single Copies: The price of a single issue is $30.00. Canadian GST Registration Number R-133130880. Second class postage paid at Washington, DC, and at additional mailing offices. PRINTED IN THE USA PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (ISSN-0027-8424) is published biweekly by THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, NW, Washington, DC 20418.
? 1996 by THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
POSTMASTER: Send address changes to: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2101 Constitution Avenue, NW, Washington, DC 20418.
Cover photograph: Galileo holding a telescope and pointing heavenward with St. Mark's cathedral and the Campanile in the background: Panel from the bronze doors at the National Academy of Sciences.
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 21:23:34 PMAll use subject to JSTOR Terms and Conditions
Proc. Natl. Acad. Sci. USA Vol. 93, January 1996
INFORMATION FOR CONTRIBUTORS
(Revised January 1996)
PURPOSE AND SCOPE The PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA publishes research reports, commentaries, reviews, col- loquium papers, and actions of the Academy. In accordance with the guiding principles established by George Ellery Hale in 1914, the PROCEEDINGS publishes brief first announcements of the Members' and Foreign Associates' (hereafter referred to as the Members) more important contributions to research and of work that appears to a Member to be of particular importance.
RESEARCH REPORTS describe the results of original experi- mental or theoretical research of exceptional importance. The papers should be of the highest scientific quality and should be intelligible to a broad scientific audience.
COMMENTARIES call attention to papers of particular note and are written at the invitation of the Editorial Board.
REviEws are usually solicited by the Editorial Board. COLLOQUIUM PAPERS are reports of symposia held under
Academy auspices. EDITORIAL POLICIES Submission and Review
Research Reports and Reviews may be submitted to the PROCEEDINGS through any of the following three tracks:
I. A Member of the Academy may "communicate" manu- scripts for non-members, provided that the communicating Member ensures that the paper undergoes thorough peer review prior to submission to the PROCEEDINGS. The Member obtains reviews of the paper from at least two qualified referees, each from a different institution and not from the author(s)' institution(s).
11. Non-members of the Academy may now submit their manuscripts directly to the PROCEEDINGS office. These authors should provide in their submission letters the names of three Members who are expert in the paper's scientific area. The full list of Members appears in issue no. 1 (January 9, 1996) of the PROCEEDINGS and is also available on the Internet at the NAS Home Page: http://www.nas.edu. Upon receipt, a directly submitted manuscript will be assigned to a Member who agrees to act as the sponsor and will select the reviewers for the paper. The name of the Member, who is anonymous to the author until the paper is accepted, will be published in the PROCEED- INGS as communicator of the article.
III. A Member of the Academy may submit his or her own manuscripts for publication. Members' submissions must be accompanied by the assurance that the manuscript has been reviewed by a knowledgeable colleague who is not a coauthor.
Manuscripts submitted under any of the three tracks are also evaluated by the Editorial Board. The Board may subject manuscripts to further review and reject those that do not meet the standards of the journal.
Journal Policies
(i) Articles are accepted on condition that thev have not been PUBLISHED previously or concurrently submitted for publication elsewhere.
(ii) AUTHORSHIP should be limited to those who have contributed substantially to the planning, execution, and in- terpretation of the work. It is assumed that all listed autnors concur in the submission.
(iii) All authors must disclose any commercial association that might pose a CONFLICT OF INTEREST in connection with
the manuscript. All funding sources supporting the work must be acknowledged.
(iv) A completed form, assigning COPYRIGHT to the Na- tional Academy of Sciences, must be returned to the PRO- CEEDINGS office after the paper is accepted for publication.
(v) The Academy may distribute EMBARGOED copies of an article to the press prior to publication.
(vi) Manuscripts that report research involving HuMAN SUBJECTS or the use of materials of human origin must be accompanied by institutional authorization.
(vii) Submission of manuscripts on research using RECOM- BINANT DNA implies that physical and biological containment conformed to National Institutes of Health guidelines or those of a corresponding agency.
(viii) Submission of manuscripts on research using UNIQUE MATERIALS (e.g., cloned DNAs; antibodies; bacterial, animal, or plant cells; viruses; and computer programs) implies that the authors will make them available to qualified researchers for noncommercial use.
(ix) DATA BASES: Accession codes must be supplied for publication.
Nucleic Acid Sequences: Authors must submit these data to GenBank/EMBL/DNA Data Bank of Japan, and the acces- sion number of the sequence must be supplied for publication.
Ciystallographic Studies of Proteins and Other Biopolymers Except Oligonucleotides: Authors must submit these data to the Protein Data Bank (PDB; Brookhaven National Laboratory).
Crystallographic Structures of Oligonucleotides: These data should be deposited directly with the Nucleic Acid Database. Once they are processed they will be forwarded to the PDB for inclusion in the central archive. To deposit the data, submit the coordinates, structure factors and current PDB deposition form to: [email protected] PROCEDURES FOR SUBMITTING MANUSCRIPTS
Corresponding Author. The name, address, telephone and fax numbers, and e-mail address of the author(s) responsible for reviewing the page proofs and/or payment of the page charges should be supplied in the transmittal letter. Manu- scripts should be mailed to PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, N.W., Washington, DC 20418, or sent by express or courier service to 1010 Wisconsin Avenue, N.W., Suite 530, Washington, DC 20007. Telephone (202) 625-4725; FAX: (202) 625-4747.
Publication Charges. Page charges: The PROCEEDINGS de- pends, in part, on the payment of page charges for its opera- tion. It is anticipated that the page charge of $65 per printed page will be paid by all authors who have funds available for that purpose. Payment of the charge is expected but is not a condition of publication; articles are accepted or rejected only on the basis of merit. Requests for waiver of page charges should be directed to the Editor-in-Chief immediately on receipt of acceptance of the paper.
Color illustration charges: Author(s) must pay the additional cost of color illustrations. The cost is $850 for the first color figure, $300 for each additional color figure. A quotation will be sent to the corresponding author when the article is accepted, and written approval must be received before the color illustrations are processed. Manuscript Preparation
Disks. To expedite both acceptance and publication, all manuscripts should be accompanied by a computer disk.
i
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 21:23:34 PMAll use subject to JSTOR Terms and Conditions
ii Information for Contributors: Proc. Natl. Acad. Sci. USA 93 (1996)
Manuscript Length. The PROCEEDINGS generally uses a two-column format having 60 characters, including spaces, per line. The length of a research article may be no more than 47,000 characters, including spaces. This includes all text and the number of characters displaced by figures, tables, and equations. The total number of characters equals The number of characters including spaces in the text (include all parts except tables), plus The number of column-centimeters of figures (submitted at the desired printed size) x 180, plus The number of column-lines of tables (one column-line = 60 characters including spaces) x 60, plus A 120-character allowance for the space above and below each single column of a figure, table, or equation. If the character count of the word processing program used to prepare the manuscript excludes spaces, the appropriate num- ber can be obtained by adding the total number of words.
EXAMPLE:
Character Material count
All text (including title page, abstract, legends, references) characters plus spaces 25,660
Fig. 1 (single column, 16 cm deep) 2,880 Fig. 2 (single column, 12 cm deep) 2,160 Fig. 3 (single column, 21 cm deep) 3,780 Fig. 4 (single column, 11 cm deep) 1,980 Fig. 5 (double column, 17 cm deep) 6,120 Table 1 (double column, 23 lines deep) 2,760 Allowance
4 single-column figures 480 1 double-column figure 240 1 double-column table 240
Total characters in paper 46,300
A table that has lines with more than 60 characters plus spaces or a figure that is wider than 8.5 cm takes up two columns in width. Overlong papers will be returned to the author.
Checklist for Submission:
Submit, with the cover letter, * Three complete copies (for track II submissions, four) of the
manuscript printed double-spaced, each accompanied by a set of figures of sufficient quality to judge the data.
* One computer disk of the text of the manuscript. Identify the platform and program in the transmittal letter.
* The total character count of the manuscript.
MANUSCRIPT FORMAT
Title Page. The following information should be included on this page:
Classification: Select one category from the following. Physical Sciences: Applied Mathematics, Applied Physical Sciences, Astronomy, Chemistry, Computer Sciences, Engineer- ing, Geology, Geophysics, Mathematics, Physics, and Statistics. Biological Sciences: Agricultural Sciences, Applied Biological Sciences, Biochemistry, Biophysics, Cell Biology, Developmental Biology, Ecology, Evolution, Genetics, Immunology, Medical Sciences, Microbiology, Neurobiology, Pharmacology, Physiol- ogy, Plant Biology, Population Biology, and Psychology. Social Sciences: Anthropology, Economic Sciences, Psychol- ogy, Political Sciences, and Social Sciences.
Title: Should not include nonstandard abbreviations and must be brief.
Key terms: Up to five key terms not included in the title are permitted.
Author affiliation: Include department, institution, and com- plete address for each author. If there are authors with different affiliations, use superscripts to match author(s) with institution(s). Identify the author to whom reprint requests should be addressed.
Abbreviations footnote: Nonstandard abbreviations used five or more times should be listed here. These should be defined where first mentioned in text and not used in the title or key terms.
Data deposition footnote: Supply all data base accession number(s) and/or code(s).
Abstract Page. Provide an abstract of no more than 250 words on page 2 of the manuscript. Abstracts should state the major contributions of the article and should be suitable for reproduction by abstracting services and on the Internet.
Text. Follow the spelling and usage given in Webster's Third New International Dictionary or the Random House Dictionary of the English Language. Avoid laboratory slang and jargon. Describe procedures in sufficient detail so that the work can be repeated. Correct chemical names should be given and strains of organisms should be specified. Trade names should be identified by an initial capital letter with the remainder of the name lowercase. Names and addresses of suppliers of uncom- mon reagents or instruments should be provided. Use Systeme International (SI) units and symbols whenever possible. When SI units are not used, the factor for conversion should be provided on first usage.
Footnotes. Symbols should be used in the order , f, t, ?, ?, **, tt, j4.
Acknowledgments. Dedications, acknowledgments, and funding sources are listed here.
References. Only published or in-press papers and books may be cited in the reference list. Abstracts of papers presented at meetings are not permissible. References should be cited in numerical order as they appear in text. Because tables and figures will be inserted in the text where first cited, references in these sections should be numbered accordingly. All authors (unless there are -20) should be named in the citation.
Databases are cited in the text or as footnotes. The corre- sponding -author must provide a signed authorization for the citation of unpublished data and personal communications.
Journal articles are cited as follows: 10. Neuhaus, J.-M., Sitcher, L., Meins, F., Jr., & Boller, T. (1991)
Proc. Natl. Acad. Sci. USA 88, 10362-10366. For correct abbreviations of journal titles, refer to Chemical
Abstracts Service Source Index (CASSI). Articles or chapters in books are cited as follows:
14. Hill, A. V. S. (1991) in Molecular Evolution of the Major Histo- compatibility Complex, eds. Klein, J. & Klein, D. (Springer, Heidelberg), pp. 403-420.
Figure Legends should be provided separately from the figures. Figures that have been published elsewhere must be iden-
tified and the permission of the copyright holder must be provided.
Original drawings, laser prints, or high-quality photographs are required for reproduction. All illustrations should be submitted at the desired printed size. They should be identified on the reverse side and the orientation should be indicated.
Color Illustrations: Submit prints (unmounted or mounted on a flexible backing) at the desired printed size (in duplicate) or slides accompanied by a print or a color photocopy indi- cating magnification and cropping needed to achieve the desired printed size.
Tables are numbered (Arabic numerals) in the order in which they are cited in the text. Each table should be on a separate page and be printed double-spaced throughout.
Nomenclature and Style. International standards on nomen- clature should be used. Recommended style guides, nomen- clature, abbreviations, and symbols are listed on the Acade- my's HIome Page: http://www.nas.edu. A printed copy may be obtained from the PROCEEDINGS office.
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 21:23:34 PMAll use subject to JSTOR Terms and Conditions
PROCEEDINGS OF THE
NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
January 23, 1996 Volume 93, Number 2 pp. 545_962
Table of Contents
INFORMATION FOR CONTRIBUTORS i-i
AUTHOR INDEX ix-x
Commentaries Evolving virus plagues John J. Holland 54S-S46
Commentary on "From local to global in H. M. Reimann 547 quasiconformal structures"
Papers from a Colloquium Cell fate determination in the vertebrate retina 589-595 Constance L. Cepko, Christopher P. Austin, Xianjie
Vision: From photon to perception 557_559 Yang, Macrene Alexiades, and Diala Ezzeddine Lubert Stryer
Molecular biology of retinal ganglion cells 596-601 How photons start vision 560-565 Mengqing Xiang, Hao Zhou, and Jeremy Nathans
Denis Baylor Emergence of order in visual system development 602-608
Gain and kinetics of activation in the G-protein 566-570 Carla J. Shatz cascade of phototransduction
T. D. Lamb Multineuronal codes in retinal signaling 609-614 Markus Meister
The biology of vision in Drosophila 571-576 Charles S. Zuker Spatial integration and cortical dynamics 615-622
Charles D. Gilbert, Aniruddha Das, Minami Ito, Primate photopigments and primate color vision 577-581 Mitesh Kapadia, and Gerald Westheimer
Gerald H. Jacobs Computational models of cortical visual processing 623-627
Circuitry for color coding in the primate retina 582-588 David J. Heeger, Eero P, Simoncelli, and Dennis M. Dacey J. Anthony Movshon
iii-
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 21:23:34 PMAll use subject to JSTOR Terms and Conditions
Contents
Motion perception: Seeing and deciding 628-633 Michael N. Shadlen and William T. Newsome
Binocular visual surface perception 634-639 Ken Nakayama
Physical Sciences
CHEMISTRY
How the first biopolymers could have evolved 839-844 V. I. Abkevich, A. M. Gutin, and E. I. Shakhnovich
GEOPHYSICS
Substructure of the inner core of the Earth 646-648 J. Marvin Herndon
MATHEMATICS
From local to global in quasiconformal structures 554-556 Juha Heinonen and Pekka Koskela
Biological Scifences
BIOCHEMISTRY
Interresidue hydrogen bonding in a peptide nucleic 649-653 acid-RNA heteroduplex
Rhonda A. Torres and Thomas C. Bruice
Apoptosis induced in Jurkat cells by several agents is 654-658 preceded by intracellular acidification
Roberta A. Gottlieb, Judy Nordberg, Evan Skowronski, and Bernard M. Babior
Analysis of differential gene expression by display of 659-663 3' end restriction fragments of cDNAs
Yatindra Prashar and Sherman M. Weissman
Targeted overexpression of androgen receptor with a 728-733 liver-specific promoter in transgenic mice
Bandana Chatterjee, Chung S. Song, Myeong H. Jung, Shuo Chen, Christi A. Walter, Damon C. Herbert, Frank J. Weaker, Michael A. Mancini, and Arun K. Roy
Tissue-specific response of the human platelet- 774-779 activating factor receptor gene to retinoic acid and thyroid hormone by alternative promoter usage
Hiroyuki Mutoh, Toru Fukuda, Takuya Kitamaoto, Shoichi Masushige, Haruna Sasaki, Takao Shimizu, and Shigeaki Kato
Z-DNA-forming sites within the human 3-globin 780-784 gene cluster
Verena Muller,7 Mieko Takeya, Susanne Brendel, Burghardt Wittig, and Alexander Rich
Resolution of Holliday junctions by eukaryotic DNA 785-789 topoisomerase I
JoAnn Sekiguchi, Nadrian C. Seeman, and Stewart Shuman
Toward antibody-directed "abzyme" prodrug therapy, 799-803 ADAPT: Carbamate prodrug activation by a catalytic antibody and its in vitro application to human tumor cell killing
Paul Wentworth, Anita Datta, David Blakey, Tom Boyle, Lynda J. Partridge, and G. Michael Blackburn
A combined kinetic and modeling study of the 804-808 catalytic center subsites of human angiogenin
Nello Russo, K. Ravi Acharya, Bert L. Vallee, and Robert Shapiro
Arabidopsis MBPI gene encodes a conserved ubiquitin 856-860 recognition component of the 26S proteasome
Steven van Nocker, Quinn Deveraux, Martin Rechsteiner, and Richard D. Vierstra
Surface hydrophobic residues of multiubiquitin chains 861-866 essential for proteolytic targeting
Richard Beal, Quinn Deveraux, Gang Xia, Martin Rechsteiner, and Cecile Pickart
Transcriptional activation of the mouse obese (ob) 873-877 gene by CCAAT/enhancer binding protein a
Cheng-Shine Hwang, Susanne Mandrup, Ormond A. MacDougald, Deborah E. Geiman, and M. Daniel Lane
Real time measurements of elongation by a reverse 889-894 transcriptase using surface plasmon resonance
Malcolm Buckle, Roy M. Williams, Matteo Negroni, and Henri Buc
Sequence-selective carbohydrate-DNA interaction: 940-944 Dimeric and monomeric forms of the calicheamicin oligosaccharide interfere with transcription factor function
Chen Liu, Brian M. Smith, Keiichi Ajito, Hironori Komatsu, Luigi Gomez-Paloma, Tianhu Li, Emmanuel A. Theodorakis, K. C. Nicolaou, and Peter K. Vogt
Sterol regulatory element binding protein binds to a 945-950 cis element in the promoter of the farnesyl diphosphate synthase gene
Johan Ericsson, Simon M. Jackson, Bernard C. Lee, and Peter A. Edwards
BIOPHYSICS
Electrical currents associated with nucleotide 664-668 transport by the reconstituted mitochondrial ADP/ATP carrier
Nickolay Brustovetsky, Anja Becker, Martin Klingenberg, and Ernst Bamberg
Preferential self-association of basic fibroblast growth 845-850 factor is stabilized by heparin during receptor dimerization and activation
Ganesh Venkataraman, V. Sasisekharan, Andrew B. Herr, David M. Ornitz, Gabriel Waksman, Charles L. Cooney, Robert Langer, and Ram Sasisekharan
Three-dimensional structure of recombinant human 878-883 osteogenic protein 1: Structural paradigm for the transforming growth factor:/ superfamily
Diana L. Griffith, Peter C. Keck, T. Kuber Sampath, David C. Rueger, and William D. Carison
iv
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 21:23:34 PMAll use subject to JSTOR Terms and Conditions
Contents
CELL BIOLOGY
The Chiorella hexose/H+ symporter is a useful 669-673 selectable marker and biochemical reagent when expressed in Volvox
Armin Hallmann and Manfred Sumper
Characterization of GMP-17, a granule membrane 685-689 protein that moves to the plasma membrane of natural killer cells following target cell recognition
Quintus G. Medley, Nancy Kedersha, Stephen O'Brien, Quinsheng Tian, Stuart F. Schlossman, Michel Streuli, and Paul Anderson
In vivo examination of membrane protein localization 828-833 and degradation with green fluorescent protein
Randolph Y. Hampton, Ann Koning, Robin Wright, and Jasper Rine
Transcriptional activation of the human 895-899 proliferating-cell nuclear antigen promoter by p53
Gilbert F. Morris, James R. Bischoff, and Michael B. Mathews
Phosphatidylinositol 3-kinase binding to polyoma virus 961 middle tumor antigen mediates elevation of glucose transport by increasing translocation of the GLUT1 transporter (Correction)
Alexander T. Young, Jean Dahl, Sharon F. Hausdorff, Paul H. Bauer, Morris J. Birnbaum, and Thomas L. Benjamin
DEVELOPMENTAL BIOLOGY
Cell cycling and patterned cell proliferation in the 640-645 wing primordium of Drosophila.
Marco Milan, Sonsoles Campuzano, and Antonio Garcia-Bellido
Caenorhabditis elegans genes sma-2, sma-3, and sma-4 790-794 define a conserved family of transforming growth factor c pathway components
Cathy Savage, Pradeep Das, Alyce L. Finelli, Scott R. Townsend, Ching-Yu Sun, Scott E. Baird, and Richard W. Padgett
Involvement of Ras/Raf/AP-1 in BMP-4 signaling 834-838 during Xenopus embryonic development
Ren-He Xu, Zigang Dong, Mitsugu Maeno, Jaebong Kim, Atsushi Suzuki, Naoto Ueno, Dvora Sredni, Nancy H. Colburn, and Hsiang-fu Kung
Restricted expression of homeobox genes distinguishes 900-905 fetal from adult human smooth muscle cells
Joseph M. Miano, Anthony B. Firulli, Eric N. Olson, Paul Hara, Cecilia M. Giachelli, and Stephen M. Schwartz
ECOLOGY
Sodium: A male moth's gift to its offspring 809-813 Scott R. Smedley and Thomas Eisner
EVOLUTION
Population dynamics of flaviviruses revaleed by 548-553 molecular phylogenies
Paolo M. de A. Zanotto, Ernest A. Gould, George F. Gao, Paul H. Harvey, and Edward C. Holmes
Muller's ratchet decreases fitness of a 906-907 DNA-based microbe
Dan I. Andersson and Diarmaid Hughes
GENETICS
A family of transmembrane proteins with homology to 674-678 the MET-hepatocyte growth factor receptor
E. Maestrini, L. Tamagnone, P. Longati, 0. Cremona, M. Gulisano, S. Bione, F. Tamanini, B. G. Neel, D. Toniolo, and P. M. Comoglio
Disruption of RB/E2F-1 interaction by single point 679-684 mutations in E2F-1 enhances S-phase entry and apoptosis
Bei Shan, Tim Durfee, and Wen-Hwa Lee
A high-resolution annotated physical map of the 690-694 human chromosome 13q12-13 region containing the breast cancer susceptibility locus BRCA2
Stuart G. Fischer, Eftihia Cayanis, Maria de Fatima Bonaldo, Anne M. Bowcock, Larry L. Deaven, Isidore S. Edelman, Theresa Gallardo, Sergei Kalachikov, Lee Lawton, J. L. Longmire, Michael Lovett, Sherri Osborne-Lawrence, Rodney Rothstein, James J. Russo, Marcelo Bento Soares, Ivana Sunjevaric, V. S. Venkatraj, Dorothy Warburton, Peiseji Zhang, and Argiris Efstratiadis
An X chromosome-linked gene encoding a protein 695-699 with characteristics of a rhoGAP predominantly expressed in hematopoietic cells
Carla Tribioli, Sara Droetto, Silvia Bione, Gianni Cesareni, Maria Rosaria Torrisi, Lavinia Vittoria Lotti, Luisa Lanfrancone, Daniela Toniolo, and PierGiuseppe Pelicci
DNA rearrangement mediated by inverted repeats 819-823 Xin Bi and Leroy F. Liu
An immunoglobulin mutator that targets G&C 851-855 base pairs
Juergen Bachl and Matthias Wabl
The chromosomal distribution of mouse odorant 884-888 receptor genes
Susan L. Sullivan, M. Charlene Adamson, Kerry J. Ressler, Christine A. Kozak, and Linda B. Buck
Significant competitive advantage conferred by 908-912 meiosis and syngamy in the yeast Saccharomyces cerevisiae
John Birdsell and Christopher Wills
Localization of the mouse gene releasing sex-limited 913-917 expression of Slp
Peter P. Jiang, Kathy Frederick, Ted H. Hansen, and Raymond D. Miller
IMMUNOLOGY
Crystallographic analysis of endogenous peptides 734-738 associated with HLA-DR1 suggests a common, polyproline 11-like conformation for bound peptides
Theodore S. Jardetzky, Jerry H. Bro ,n Joan C. Gorga, Lawrence J. Stern, Robert G. Urban, Jack L. Strominger, and Don C. Wiley
v
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 21:23:34 PMAll use subject to JSTOR Terms and Conditions
Contents
Manipulation and potentiation of antimycobacterial 934-939 immunity using recombinant bacille Calmette-Guerin strains that secrete cytokines
Peter J. Murray, Anna Aldovini, and Richard A. Young
B cells are not essential for peripheral T-cell tolerance 951-955 Anthony T. Vella, Mark T. Scherer, Leonard Shultz, John W. Kappler, and Philippa Marrack
Protection of nonobese diabetic mice from diabetes by 956-960 intranasal or subcutaneous administration of insulin peptide B-(9-23)
Dylan Daniel and Dale R. Wegmann
MEDICAL SCIENCES
Human immunodeficiency virus type 1 infection alters 700-704 chemokine f3 peptide expression in human monocytes: Implications for recruitment of leukocytes into brain and lymph nodes
Helena Schmidtmayerova, Hans S. L. M. Nottet, Gerard Nuovo, Tobias Raabe, Clinton R. Flanagan, Larisa Dubrovsky, Howard E. Gendelman, Anthony Cerami, Michael Bukrinsky, and Barbara Sherry
Male fetal progenitor cells persist in maternal blood 705-708 for as long as 27 years postpartum
Diana W. Bianchi, Gretchen K. Zickwolf, Gary J. Weil, Shelley Sylvester, and Mary Ann DeMaria
Antimycobacterial activities of antisense 709-713 oligodeoxynucleotide phosphorothioates in drug-resistant strains
Eliezer Rapaport, Asya Levina, Valeri Metelev, and Paul C. Zamecnik
Endogenous c-src as a determinant of the 824-827 tumorigenicity of src oncogenes
Michael S. Halpern, James M. England,-Gene C. Kopen, Alexander A. Christou, and Robert L. Taylor, Jr.
Null mutation of endothelin receptor type B gene in 867-872 spotting lethal rats causes aganglionic megacolon and white coat color
Cheryl E. Gariepy, Daniel T. Cass, and Masashi Yanagisawa
NEUROBIOLOGY
Recruitment and replacement of hippocampal neurons 714-718 in young and adult chickadees: An addition to the theory of hippocampal learning
Anat Barnea and Fernando Nottebohm
Pars triangularis asymmetry and language dominance 719-722 Anne L. Foundas, Christiana M. Leonard, Robin L. Gilmore, Eileen B. Fennell, and Kenneth M. Heilman
Channel behavior in a y-aminobutyrate transporter 723-727 J. N. Cammack and E. A. Schwartz
Formation of mnemonic neuronal responses to visual 739-743 paired associates in inferotemporal cortex is impaired by perirhinal and entorhinal lesions
Sei-ich n Aguchi and Yasushi Miyashita
Vascular variant of prion protein cerebral amyloidosis 744-748 with 7-positive neurofibrillary tangles: The phenotype of the stop codon 145 mutation in PRNP
Bernardino Ghetti, Pedro Piccardo, Maria Grazia Spillantini, Yousuke Ichimiya, Monica Porro, Francesco Perini, Tetsuyuki Kitamoto, Jun Tateishi, Charles Seiler, Blas Frangione, Orso Bugiani, Giorgio Giaccone, Frances Prelli, Michel Goedert, Stephen R. Dlouhy, and Fabrizio Tagliavini
Prostate-specific membrane antigen is a hydrolase 749-753 with substrate and pharmacologic characteristics of a neuropeptidase
Ruth E. Carter, Alexis R. Feldman, and Joseph T. Coyle
Gangliosides are neuronal ligands for 814-818 myelin-associated glycoprotein
Lynda J.-S. Yang, Cynthia B. Zeller, Nancy L. Shaper, Makoto Kiso, Akira Hasegawa, Robert E. Shapiro, and Ronald L. Schnaar
Face encoding and recognition in the human brain 922-927 James V. Haxby, Leslie G. Ungerleider, Barry Horwitz, Jose Ma. Maisog, Stanley I. Rapoport, and Cheryl L. Grady
Intracerebral injection of human immunodeficiency 928-933 virus type 1 coat protein gpl20 differentially affects the expression of nerve growth factor and nitric oxide synthase in the hippocampus of rat
Giacinto Bagetta, M. Tiziana Corasaniti, Luigi Aloe, Laura Berliocchi, Nicola Costa, Alessandro Finazzi-Agro, and Giuseppe Nistic6
PHARMACOLOGY
Nuclease-resistant ribozymes decrease stromelysin 754-758 mRNA levels in rabbit synovium following exogenous delivery to the knee joint
Craig M. Flory, Pamela A. Pavco, Thale C. Jarvis, Mark E. Lesch, Francine E. Wincott, Leonid Beigelman, Stephen W. Hunt III, and Denis J. Schrier
PHYSIOLOGY
Heme oxygenase 2: Endothelial and neuronal 795-798 localization and role in endothelium- dependent relaxation
Randa Zakhary, Sean P. Gaine, Jay L. Dinerman, Martial Ruat, Nicholas A. Flavahan, and Solomon H. Snyder
PLANT BIOLOGY
Integration of multiple repeats of geminiviral DNA 759-764 into the nuclear genome of tobacco during evolution
Eduardo R. Bejarano, Alaa Khashoggi, Michael Witty, and Conrad Lichtenstein
A gene encoding a mitogen-activated protein kinase 765-769 kinase kinase is induced simultaneously with genes for a mitogen-activated protein kinase and an S6 ribosomal protein kinase by touch, cold, and water stress in Arabidopsis thaliana
Tsuyoshi Mizoguchi, Kenji Irie, Takashi Hirayama, Nobuaki Hayashida, Kazuko Yamaguchi-Shinozaki, Kunihiro Matsumoto, and Kazuo Shinozaki
vi
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 21:23:34 PMAll use subject to JSTOR Terms and Conditions
Contents POPULATION BIOLOGY
Molecular markers reveal cryptic sex in the human 770-773 pathogen Coccidioides immitis
Austin Burt, Deidre A. Carter, Gina L. Koenig, Thomas J. White, and John W. Taylor
Fate of biological control introductions: Monitoring 918-921 an Australian fungal pathogen of grasshoppers in North America
Michael J. Bidochka, Scott R. A. Walsh, Mark E. Ramos, Raymond J. St. Leger, Julie C. Silver, and Donald W. Roberts
vii
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 21:23:34 PMAll use subject to JSTOR Terms and Conditions