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OF THE

NAT~IONALACADMY F CIECE TO , HE UTED STCATE OF AMErIA

February~~~~~~~~~~ 6,19 Volume 93/ Number 3~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

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Proc. Natl. Acad. Sci. USA Vol. 93, February 1996

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ii Information for Contributors Proc. Natl. Acad. Sci. USA 93 (1996)

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PROCGELDINGS OF THE

NATIONAL ACADEMY OF SCIENCES

OF THE UNITED STATES OF AMERICA

February 6, 1996 Volume 93, Number 3 pp. 963-1358

Table of Contents

INFORMATION FOR CONTRIBUTORS i-i

AUTHOR INDEX ix-x

Biological Sciences A new selenoprotein from human lung 1006-1011 adenocarcinoma cells: Purification, properties, and thioredoxin reductase activity

BIOCHEMISTRY Takashi Tamura and Thressa C. Stadtman

Identification of residues that control specific binding 963-968 Compressibility as a means to detect and characterize 1012-1014 of the Shc phosphotyrosine-binding domain to globular protein states phosphotyrosine sites Tigran V. Chalikian and Kenneth J. Breslauer

Peter van der Geer, Sandra Wiley, Gerald D. Gish, Venus Ka-Man Lai, Robert Stephens, Morris F. Kriippel-associated box-mediated repression of RNA 1015-1020 White, David Kaplan, and Tony Pawson polymerase II promoters is influenced by the

arrangement of basal promoter elements The in vitro ejection of zinc from human 969-973 Gina Pengue and Luigi Lania immunodeficiency virus (HIV) type 1 nucleocapsid protein by disulfide benzamides with cellular Sterol regulation of acetyl coenzyme A carboxylase: A 1049-1053 anti-HIV activity mechanism for coordinate control of cellular lipid

Peter J. Tummino, Jeffrey D. Scholten, Patricia J. Jose M. Lopez, Mary K. Bennett, Hugo B. Sanchez, Harvey, Tod P. Holler, Lisa Maloney, Rocco John M. Rosenfeld, and Timothy F. Osborne Gogliotti, John Domagala, and Donald Hupe

Transcriptional regulation of human inducible nitric 1054-1059 Catalytic activity of the mouse guanine nucleotide 1001-1005 oxide synthase (N0S2) gene by cytokines: Initial exchanger mSOS is activated by Fyn tyrosine protein analysis of the human N0S2 promoter kinase and the T-cell antigen receptor in T cells Michael E. de Vera, Richard A. Shapiro, Andreas

Bao-qun Li, Marianne Subleski, Noemi Fusaki, K. Nussler, John S. Mudgett, Richard L. Simmons, Tadashi Yamamoto, Terry Copeland, Gerald L. Sidney M. Morris, Jr., Timothy R. Billiar, and Princler, Hsiang-fu Kung, and T ohru Kamata David A. Geller

111

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Contents

Hsp90 is required for the activity of a hepatitis B 1060-1064 virus reverse transcriptase

Jianming Hu and Christoph Seeger

An auxiliary factor containing a 240-kDa protein 1097-1102 complex is involved in apolipoprotein B RNA editing

Dolores Schock, Shu-Ru Kuo, Michael F. Steinburg, Mary Bolognino, Janet D. Sparks, Charles E. Sparks, and Harold C. Smith

Protein-protein interactions in eukaryotic 1119-1124 transcription initiation: Structure of the preinitiation complex

Hong Tang, Xiaoqing Sun, Danny Reinberg, and Richard H. Ebright

Role of hydrophobic interactions and desolvation in 1135-1140 determining the structural properties of a model a/3 peptide

Daniel J. Butcher and Gregory R. Moe

Differential functions of the two Src homology 2 1141-1145 domains in protein tyrosine phosphatase SH-PTP1

Dehua Pei, Jun Wang, and Christopher T. Walsh

The wing of the enhancer-binding domain of Mu 1146-1150 phage transposase is flexible and is essential for efficient transposition

Robert T. Clubb, Michiyo Mizuuchi, Jeffrey R. Huth, James G. Omichinski, Harri Savilahti, Kiyoshi Mizuuchi, G. Marius Clore, and Angela M. Gronenborn

Hybrid restriction enzymes: Zinc finger fusions to 1156-1160 Fok I cleavage domain

Yang-Gyun Kim, Jooyeun Cha, and Srinivasan Chandrasegaran

Transcriptional activation by protein-induced DNA 1173-1177 bending: Evidence for a DNA structural transmission model

Bhavin S. Parekh and G. Wesley Hatfield

Myristate exchange on the Trypanosoma brucei 1178-1183 variant surface glycoprotein

Laurence U. Buxbaum, Kenneth G. Milne, Karl A. Werbovetz, and Paul T. Englund

Multiplex selection technique (MuST): An approach 1184-1189 to clone transcription factor binding sites

Girish N. Nallur, Kulkarni Prakash, and Sherman M. Weissman

Structure-activity analysis of thanatin, a 21-residue 1221-1225 inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides

Pascale Fehlbaum, Philippe Bulet, Serguey Chernysh, Jean-Paul Briand, Jean-Pierre Roussel, Lucienne Letellier, Charles Hetru, and Jules A. Hoffmann

Isolation of an oxygen-sensitive FNR protein of 1226-1231 Escherichia coli: Interaction at activator and repressor sites of FNR-controlled genes

Stephen B. Melville and Robert P. Gunsalus

Cloning of human adenosine kinase cDNA: Sequence 1232-1237 similarity to microbial ribokinases and fructokinases

Jozef Spychala, Nabanita S. Datta, Kenji Takabayashi, Milton Datta, Irving H. Fox, Thomas Gribbin, and Beverly S. Mitchell

P-glycoprotein confers methotrexate resistance in 1238-1242 3T6 cells with deficient carrier-mediated methotrexate uptake

David de Graaf, Rakesh C. Sharma, Eugene B. Mechetner, Robert T. Schimke, and Igor B. Roninson

BIOPHYSICS

Structural changes of tumor necrosis factor a 1021-1026 associated with membrane insertion and channel formation

Rae Lynn Baldwin, Mark L. Stolowitz, Leroy Hood, and Bernadine J. Wisnieski

On the nucleation and growth of amyloid /-protein 1125-1129 fibrils: Detection of nuclei and quantitation of rate constants

Aleksey Lomakin, Doo Soo Chung, George B. Benedek, Daniel A. Kirschner, and David B. Teplow

CELL BIOLOGY

Translation initiation of ornithine decarboxylase and 1065-1070 nucleocytoplasmic transport of cyclin DI mRNA are increased in cells overexpressing eukaryotic initiation factor 4E

Denis Rousseau, Roger Kaspar, Igor Rosenwald, Lee Gehrke, and Nahum Sonenberg

Clustered syk tyrosine kinase domains 1103-1107 trigger phagocytosis

Steven Greenberg, Peter Chang, Da-cheng Wang, Ramnik Xavier, and Brian Seed

Genetic engineering of carbohydrate biosynthetic 1161-1166 pathways in transgenic mice demonstrates cell cycle-associated regulation of glycoconjugate production in small intestinal epithelial cells

Lynn Bry, Per G. Falk, and Jeffrey I. Gordon

HLH106, a Drosophila transcription factor with 1195-1199 similarity to the vertebrate sterol responsive element binding protein

Ulrich Theopold, Sophia Ekengren, and Dan Hultmark

Substance P responsiveness of smooth muscle cells is 1276-1281 regulated by the integrin ligand, thrombospondin

Lisa M. Dahm and Chauncey W. Bowers

A technique for detecting matrix proteins in the 1282-1286 crystalline spicule of the sea urchin embryo

Jin Won Cho, Jacqueline S. Partin, and William J. Lennarz

Heteromeric connexons in lens gap junction channels 1287-1291 Jean X. Jiang and Daniel A. Goodenough

iv

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Contents

DEVELOPMENTAL BIOLOGY

Origin and evolution of circular waves and spirals in 1151-1155 Dictyostelium discoideum territories

Eirfkur Palsson and Edward C. Cox

Dominant-negative mutant thyroid hormone receptors 1205-1209 prevent transcription from Xenopus thyroid hormone receptor f3 gene promoter in response to thyroid hormone in Xenopus tadpoles in vivo

Salvatore Ulisse, Graeme Esslemnont, Betty S. Baker, V. Krishna K. Chatterjee, and Jamshed R. Tata

EVOLUTION

Archaeal-eubacterial mergers in the origin of 1071-1076 Eukarya: Phylogenetic classification of life

Lynn Margulis

Phylogenetic resolution within the Elephantidae using 1190-1194 fossil DNA sequence from the American mastodon (Mammut americanum) as an outgroup

Hong Yang, Edward M. Golenberg, and Jeheskel Shoshani

GENETICS

Identification of a minimal sequence of the mouse 1027-1031 pro-al(I) collagen promoter that confers high-level osteoblast expression in transgenic mice and that binds a protein selectively present in osteoblasts

Jerome A. Rossert, Su Sin Chen, Heidi Eberspaecher, Chad N. Smith, and Benoit de Crombrugghe

DANA elements: A family of composite, tRNA- 1077-1081 derived short interspersed DNA elements associated with mutational activities in zebrafish (Danio rerio)

Zsuzsanna Izsvak, Zoltan Ivics, David Garcia-Estefania, Scott C. Fahrenkrug, and Perry B. Hackett

Fine mapping of colon tumor susceptibility (Scc) 1082-1086 genes in the mouse, different from the genes known to be somatically mutated in colorn cancer

Corina J. A. Moen, Peter C. Groot, Augustinus A. M. Hart, Margriet Snoek, and Peter Demant

Transformation of Plasmodium falciparum malaria 1130-1134 parasites by homologous integration of plasmids that confer resistance to pyrimethamine

Yimin Wu, Laura A. Kirkman, and Thomas E. Wellems

The chicken f32-microglobulin gene is located on a 1243-1248 non-major histocompatibility complex microchromosome: A small, G+C-rich gene with X and Y boxes in the promoter

Patricia Riegert, Rolf Andersen, Nat Bumstead, Christian D6hring, Marina Dominguez-Steglich, Jan Engberg, Jan Salomonsen, Michael Schmid, Joseph Schwager, Karsten Skj0dt, and J-im Kaufman

Products of DNA mismatch repair genes mutS and 1292-1297 mutL are required for transcription-coupled nucleotide-excision repair of the lactose operon in Escherichia coli

Isabel Mellon and Gregory N. Champe

A compositional map of human chromosome 1298-1302 band Xq28

Albertina De Sario, Eva-Maria Geigl, Giuseppe Palmieri, Michele D'Urso, and Giorgio Bernardi

Lens complementation system for the genetic analysis 1303-1307 of growth, differentiation, and apoptosis in vivo

Nanette J. Liegeois, James W. Horner, and Ronald A. DePinho

Antiproliferative properties of the USF family of 1308-1313 helix-loop-helix transcription factors

Xu Luo and Michele Sawadogo

Extending the chemistry that supports genetic 1352-1356 information transfer in vivo: Phosphorothioate DNA, phosphorothioate RNA, 2'-O-methyl RNA, and methylphosphonate DNA

David S. Thaler, Shumo Liu, and Gregory Tombline

IMMUNOLOGY

Improved antitumor activity of a recombinant 974-978 anti-LewisY immunotoxin not requiring proteolytic activation

Chien-Tsun Kuan and Ira Pastan

In vivo anergized CD4+ T cells express perturbed 979-984 AP-1 and NF-KB transcription factors

Anette Sundstedt, Mikael Sigvardsson, Tomas Leanderson, Gunnar Hedlund, Terje Kalland, and Mikael Dohlsten

Antigenic variation and the within-host dynamics 985-989 of parasites

Rustom Antia, Martin A. Nowak, and Roy M. Anderson

A role of Hsp60 in autoimmune diabetes: 1032-1037 Analysis in a transgenic model

Ohad S. Birk, Daniel C. Douek, Dana Elias, Katalin Takacs, Hamlata Dewchand, Sara L. Gur, Michael D. Walker, Ruurd van der Zee, Irun R. Cohen, and Daniel M. Altmann

MEDICAL SCIENCES

Olfactory neuroblastoma is a peripheral primitive 1038-1043 neuroectodermal tumor related to Ewing sarcoma

Poul H. B. Sorensen, John K. Wu, Ken W. Berean, Jerian F. Lim, Wayne Donn, Henry F. Frierson, C. Patrick Reynolds, Dolores L6pez-Terrada, and Timothy J. Triche

The chimeric genes AMLl1/MDSl and AML1/EAP 1044-1048 inhibit AML1B activation at the CSF1R promoter, but only AML1 /MDS1 has tumor-promoter properties

Clive S. Zent, Carol Mathieu, David E. Claxton, Dong-Er Zhang, Daniel G. Tenen, Janet D. Rowley, and Giuseppina Nucifora

v

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Contents

DNA damage enhances melanogenesis 1087-1092 Mark S. Eller, Kristin Ostrom, and Barbara A. Gilchrest

Mutation detection by highly sensitive methods 1093-1096 indicates that p53 gene mutations in breast cancer can have important prognostic value

J. S. Kovach, A. Hartmann, H. Blaszyk, J. Cunningham, D. Schaid, and S. S. Sommer

Uptake of fluorescent dyes associated with the 1167-1172 functional expression of the cystic fibrosis transmembrane conductance regulator in epithelial cells

Robert P. Wersto, Eugene R. Rosenthal, Ronald G. Crystal, and Kenneth R. Spring

A close relative of the adrenoleukodystrophy (ALD) 1265-1269 gene codes for a peroxisomal protein with a specific expression pattern

Gael Lombard-Platet, Stephane Savary, Claude-Olivier Sarde, Jean-Louis Mandel, and Giovanna Chimini

Transfer of f3-amyloid precursor protein gene using 1314-1319 adenovirus vector causes mitochondrial abnormalities in cultured normal human muscle

V. Askanas, J. McFerrin, S. Baque, R. B. Alvarez, E. Sarkozi, and W. K. Engel

Efficient generation of recombinant adenoviruses 1320-1324 using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome

Sanae Miyake, Miho Makimura, Yumi Kanegae, Shizuko Harada, Yumi Sato, Koichi Takamori, Chikashi Tokuda, and Izumu Saito

Membrane-associated CD19-LYN complex is an 1357 endogenous p53-independent and Bcl-2-independent regulator of apoptosis in human B-lineage lymphoma cells (Correction)

Dorothea E. Myers, Xiao Jun, Kevin G. Waddick, Craig Forsyth, Lisa M. Chelstrom, Roland L. Gunther, Nilgun E. Tumer, Joseph Bolen, and Fatih M. Uckun

MICROBIOLOGY

Equine rhinovirus 1 is more closely related to 990-995 foot-and-mouth disease virus than to other picornaviruses

Feng Li, Glenn F. Browning, Michael J. Studdert, and Brendan S. Crabb

A cell cycle-regulated bacterial DNA 1210-1.214 methyltransferase is essential for viability

Craig Stephens, Ann Reisenauer, Rachel Wright, and Lucy Shapiro

The secreted Ipa complex of Shigella flexneri promotes 1254-1258 entry into mammalian cells

Robert Menard, Marie-Christine Prevost, Pierre Gounon, Philippe Sansonetti, and Christoph Dehio

Helicobacter pylori attachment to gastric cells induces 1259-1264 cytoskeletal rearrangements and tyrosine phosphorylation of host cell proteins

Ellyn D. Segal, S. Falkow, and L. S. Tompkins

NEUROBIOLOGY

Hyperalgesic agents increase a tetrodotoxin-resistant 1108-1112 Na+ current in nociceptors

Michael S. Gold, David B. Reichling, Michael J. Shuster, and Jon D. Levine

Stimulation of growth factor receptor signal 1113-1118 transduction by activation of voltage-sensitive calcium channels

Laura B. Rosen and Michael E. Greenberg

Regulation of N-methyl-D-aspartate-induced toxicity 1200-1204 in the neostriatum: A role for metabotropic glutamate receptors?

Christopher S. Colwell, Katharine L. Altemus, Carlos Cepeda, and Michael S. Levine

Preserved speech abilities and compensation 1249-1253 following prefrontal damage

Randy L. Buckner, Maurizio Corbetta, Jeffrey Schatz, Marcus E. Raichle, and Steven E. Petersen

Neuronal abnormalities in microtubule-associated 1270-1275 protein lB mutant mice

Winfried Edelmann, Mark Zervas, Pamela Costello, Linda Roback, Itzhak Fischer, James A. Hammarback, Nicholas Cowan, Peter Davies, Bruce Wainer, and Raju Kucherlapati

Increased dopamine turnover in the prefrontal cortex 1325-1329 impairs spatial working memory performance in rats and monkeys

B. L. Murphy, A. F. T. Arnsten, P. S. Goldman-Rakic, and R. H. Roth

Synergy between chronic corticosterone and sodium 1330-1334 azide treatments in producing a spatial learning deficit and inhibiting cytochrome oxidase activity

M. Catherine Bennett, Gary W. Miady, Monika Fleshner, and Gregory M. Rose

Short-term synaptic enhancement and long-term 1335-1339 potentiation in neocortex

Manuel A. Castro-Alamancos and Barry W. Connors

PHYSIOLOGY

31p magnetic resonance spectroscopy of the Sherpa 1215-1220 heart: A phosphocreatine/adenosine triphosphate signature of metabolic defense against hypobaric hypoxia

P. W. Hochachka, C. M. Clark, J. B. Holden, C. Stanley, K. Ugurbil, and R. S. Menon

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Contents Role of guanine nucleotide-binding 1340-1345 proteins-ras-family or trimeric proteins or both- in Ca2+ sensitization of smooth muscle

Ming Cui Gong, Kunihiko lizuka, Graeme Nixon, J. Peter Browne, Alan Hall, John F. Eccleston, Motoyuki Sugai, Sei Kobayashi, Avril V. Somlyo, and Andrew P. Somlyo

PLANT BIOLOGY

Transcription of tufA and other chloroplast-encoded 996-1000 genes is controlled by a circadian clock in Chlamydomonas

Seongbin Hwang, Ryo Kawazoe, and David L. Herrin

Social Sciences

PSYCHOLOGY

Preserved speech abilities and compensation 1249-1253 following prefrontal damage

Randy L. Buckner, Maurizio Corbetta, Jeffrey Schatz, Marcus E. Raichle, and Steven E. Petersen

Cue recognition and cue elaboration in learning 1346-1351 from examples

Xinming Zhu, Yifei Lee, Herbert A. Simon, and Dan Zhu

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