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PROCEEDINGS OF THE

NATIONAL ACADEMY OF S CIENCES

OF THE UNITED STATES OF AMERICA

May 14, 1996

Volume 93/ Number 10



PROCEEDINGS OF THE

NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Officers BRUCE ALBERTS, President of the JACK HALPERN, Vice President Academy PETER H. RAVEN, Home Secretary

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A OF

OF THE

\ IF

NATIONAL ACA~~~~~~~~~~~~PDEMY OFSCINE

OF THE UNITED STATES OF AMERICA

May 14, 1996 Volume 93, Number 10 pp. 4521-5172

Table of Contents

CONDENSED INFORMATION FOR CONTRIBUTORS

AUTHOR INDEX ix-xi

Commentaries Culture as shared cognitive representations 4699-4705 A. Kimball Romney, John P. Boyd, Carmella C.

Origin of genetic code: A needle in the haystack of 4521-4522 Moore, William H. Batchelder, and Timothy tRNA sequences J. Brazill

Paul Schimmel

Does DG42 synthesize hyaluronan or chitin?: A 4523-4525 The control of hematopoiesis and leukemia: From 4742-4749 controversy about oligosaccharides in basic biology to the clinic vertebrate development Leo Sachs

Ajit Varki

Retinitis pigmentosa: Unfolding its mystery 4526-4528 Eliot L. Berson Physical Sciences

Review CHEMISTRY

Onconeural antigens and the paraneoplastic 4529-4536 Controlling protein association and subcellular 4604-4607 neurologic disorders: At the intersection of cancer, localization with a synthetic ligand that induces immunity, and the brain heterodimerization of proteins

Robert B. Darnell Peter J. Belshaw, Steffan N. Ho, Gerald R. Crabtree, and Stuart L. Schreiber

Inaugural Artickes Regulation of the retinoblastoma protein-related 4633-4637 GEOLOGY protein plO7 by G1 cyclin-associated kinases

Zhi-Xiong Xiao, Doron Ginsberg, Mark Ewen, Ediacaran biota from Sonora, Mexico 4990-4993 and David M. Livingston Mark A. S. McMenamin

.i.i



Contents

Biological Sciences Novel retinoic acid receptor ligands in Xenopus embryos 4873-4878 Bruce Blumberg, Jack Bolado, Jr., Fadila Derguini, A. Grey Craig, Tanya A. Moreno, Debabrata

BIOCHEMISTRY Chakravarti, Richard A. Heyman, Jochen Buck, and Ronald M. Evans

Cells expressing the DG42 gene from early Xenopus 4543-4547 embryos synthesize hyaluronan Complementation analysis of mutants of nitric oxide 4891-4896

Michael F. Meyer and Gunther Kreil synthase reveals that the active site requires two hemes

Structure and function in rhodopsin: Correct folding 4554-4559 Qiao-wen Xie, Mary Leung, Michele Fuortes, and misfolding in two point mutants in the intradiscal Shigeru Sassa, and Carl Nathan domain of rhodopsin identified in retinitis pigmentosa Using ubiquitin to follow the metabolic fate of 4907-4912

Xun Liu, Pere Garriga, and H. Gobind Khorana Usin a protein Structure and function in rhodopsin: Correct folding 4560-4564 Fr6d6ric L6vy, Nils Johnsson, Tillmann Rumenapf, and misfolding in point mutants at and in proximity to and Alexander Varshavsky the site of the retinitis pigmentosa mutation Leu-125

Arg sine of the retrnitismeigmbranet Cutation

Leu-125 Internal cleavage of the inhibitory 7B2 carboxyl- 4919-4924 Arg in the transmembrane helix C tria etd yP2 oeta ehns

Pere Garriga, Xun Liu, and H. Gobind Khorana terminal peptide by PC2: A potential mechanism for its inactivation

Functional interaction and colocalization of the herpes 4572-4576 X. Zhu, Y. Rouille, N. S. Lamango, D. F. Steiner, simplex virus 1 major regulatory protein ICP4 with and I. Lindberg EAP, a nucleolar-ribosomal protein Translational regulation of mammalian and Drosophila 4925-4930 Rosario Leopardi and Bernard Roizman

citric acid cycle enzymes via iron-responsive elements

The hard-soft acid-base principle in enzymatic 4612-4616 Nicola K. Gray, Kostas Pantopoulos, Thomas . . ~~~~~~~~~~~~Dandekar, Brian A. C. Ackrell, catalysis: Dual reactivity of phosphoenolpyruvate DandeMatthias W..Henze

Yan Li and Jeremy N. S. Evans

Role of the regulatory subunit of bovine pyruvate 4953-4956 Myocyte-specific enhancer factor 2 acts cooperatively 4623-4628 dehogenaephsatase with a muscle activator region to regulate Drosophila Jiangonan, Jataso

tropomyosin gene muscle expression Jiangong Yan, Janet E. Lawson, and Lester J. Reed tropomyosin gene muscle expression' Meei-Hua Lin, Hanh T. Nguyen, Claire Dybala, An AML-1 consensus sequence binds an osteoblast- 4968-4973 and Robert V. Storti specific complex and transcriptionally activates the

osteocalcin gene Expression cloning of a cDNA for human ceramide 4638-4643 Catali Bane glucosyltransferase that catalyzes the first glycosylation Jane B. Lian, and Gary S. Stein step of glycosphingolipid synthesis

Shinichi Ichikawa, Hisako Sakiyama, Gen Suzuki, Escherichia coli exhibits negative chemotaxis in 4999-5002 Kazuya I.-P. Jwa Hidari, and Yoshio Hirabayashi gradients of hydrogen peroxide, hypochlorite, and

N-chlorotaurine: Products of the respiratory Peroxo-iron and oxenoid-iron species as alternative 4644-4648 burst of phagocytic cells oxygenating agents in cytochrome P450-catalyzed Ludmil Benov a Ii d c Ludmil Benov and Irwin Fridovich reactions: Switching by Threonine-302 to Alanine mutagenesis of cytochrome P450 2B4 Functional complementation of xeroderma pigmentosum 5014-5018

Alfin D. N. Vaz, Steven J. Pernecky, Gregory M. complementation group E by replication protein A in an Raner, and Minor J. Coon in vitro system

Aleksey Kazantsev, David Mu, Anne F. Nichols, Dexamethasone responsiveness of a major 4666-4670 Xiaodong Zhao, Stuart Linn, and Aziz Sancar glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor Exploring the active site of chorismate mutase by 5043-5048 binding motif combinatorial mutagenesis and selection: The

Janice M. Huss, Steven I. Wang, Anders Astrom, importance of electrostatic catalysis Patricia McQuiddy, and Charles B. Kasper Peter Kast, M. Asif-Ullah, Ning Jiang,

and Donald Hilvert DNA sequencing by delayed extraction-matrix-assisted 4724-4729 laser desorption/ionizaton time of flight mass Glucocorticoid and progestin receptors are differently 5072-5077 spectrometry involved in the cooperation with a structural element

Mark T. Roskey, Peter Juhasz, Igor P. Smirnov, of the mouse mammary tumor virus promoter Edward J. Takach, Stephen A. Martin, S. Le Ricousse, F. Gouilleux, D. Fortin, V. Joulin, and Lawrence A. Haff and H. Richard-Foy

Targeted replacement of the mycocerosic acid 4787-4792 A yeast manganese transporter related to the 5105-5110 synthase gene in Mycobacterium bovis BCG produces a macrophage protein involved in conferring mutant that lacks mycosides resistance to mycobacteria

Abul K. Azad, Tatiana D. Sirakova, Linda M. Frantisek Supek, Lubica Supekova, Hannah Nelson, Rogers, and Pappachan E. Kolattukudy and Nathan Nelson

iv



Contents Inducible expression of an antibiotic peptide gene in 5156-5160 Visualization of glucocorticoid receptor translocation 4845-4850 lipopolysaccharide-challenged tracheal epithelial cells and intranuclear organization in living cells with a

Gill Diamond, John P. Russell, green fluorescent protein chimera and Charles L. Bevins Han Htun, Julia Barsoniy, Istvan Renyi, Daniel L.

Gould, and Gordon L. Hager

BIOPHYSICS Crystal structure of a human TATA box-binding 4862-4867

Responses of the phototransduction cascade to 4677-4682 protein/TATA element complex dim light Dimitar B. Nikolov, Hua Chen, Elaine D. Halay,

Gwenn Langlois, Ching-Kang Chen, Krzysztof Alexander Hoffmann, Robert G. Roeder, Palczewski, James B. Hurley, and T. Minh Vuong and Stephen K. Burley

Sequence-specific DNA-binding dominated 4754-4759 Two Arabidopsis cyclin promoters mediate distinctive 4868-4872

Sydequencerspecif DNA-binding dominated

transcriptional oscillation in synchronized tobacco by dehydration Thomas Lundback and Torleif Hard BY-2 cells

Orit Shaul, Vladimir Mironov, Sylvia Burssens,

Two-dimensional protein crystallization via metal-ion 4937-4941 Marc Van Montagu, and Dirk Inz6

coordination by naturally occurring surface histidines GRIPI1, a novel mouse protein that serves as a 4948-4952 Wolfgang Frey, William R. Schief, Jr., Daniel W. transcriptional coactivator in yeast for the hormone Pack, Chao-Tsen Chen, Ashutosh Chilkoti, Patrick binding domains of steroid receptors Stayton, Viola Vogel, and Frances H. Arnold Heng Hong, Kulwant Kohli, Alpa Trivedi, Deborah

How optimization of potential functions affects 4984-4989 L. Johnson, and Michael R. Stallcup protein folding Cloning and expression of apoptosis inhibitory protein 4974-4978

Ming-Hong Hao and Harold A. Scheraga homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors

CELL BIOLOGY Anthony G. Uren, Miha Pakusch, Christine J. Hawkins, Kirsten L. Puls, and David L. Vaux

Single cell Ca2+/cAMP cross-talk monitored by 4577-4582 simultaneous Ca2+/cAMP fluorescence ratio imaging Functional expression of the Schizosaccharomyces 5031-5036

Maria A. DeBernardi and Gary Brooker pombe Na+/H+ antiporter gene, sod2, in Saccharomyces cerevisiae

Controlling protein association and subcellular 4604-4607 Karen M. Hahnenberger, Zhengping Jia, localization with a synthetic ligand that induces and Paul G. Young heterodimerization of proteins

Peter J. Belshaw, Steffan N. Ho, Gerald R. The cloned rat pancreatic polypeptide receptor 5111-5115 Crabtree, and Stuart L. Schreiber exhibits profound differences to the orthologous

human receptor The platelet-derived growth factor a-receptor is 4617-4622 Ingrid Lundell, Michael A. Statnick, Dwayne encoded by a growth-arrest-specific (gas) gene Johnson, Douglas A. Schober, Paula Starback,

Chih-Jian Lih, Stanley N. Cohen, Chiayeng Wang, Donald R. Gehlert, and Dan Larhammar and Sue Lin-Chao

The C-proteinase that processes procollagens to 5127-5130 Regulation of the retinoblastoma protein-related 4633-4637 fibrillar collagens is identical to the protein previously protein p107 by G1 cyclin-associated kinases identified as bone morphogenic protein-I

Zhi-Xiong Xiao, Doron Ginsberg, Mark Ewen, Shi-Wu Li, Aleksander L. Sieron, Andrzej Fertala, and David M. Livingston Yoshio Hojima, William V. Arnold,

and Darwin J. Prockop Mos/mitogen-activated protein kinase can induce 4730-4735 early meiotic phenotypes in the absence of In its active form, the GTP-binding protein rab8 5151-5155 maturation-promoting factor: A novel system for interacts with a stress-activated protein kinase analyzing spindle formation during meiosis I Mindong Ren, Jianbo Zeng, Carmen De

Taesaeng Choi, Shen Rulong, James Resau, Kenji Lemos-Chiarandini, Melvin Rosenfeld, Milton Fukasawa, Wayne Matten, Ryoko Kuriyama, Sam Adesnik, and David D. Sabatini Mansour, Natalie Ahn, and George F. Vande Woude Oscillations in KATP channel activity promote 5161-5165

oscillations in cytoplasmic free Ca2+ concentration

High resolution ultrastructural mapping of total 4799-4803 in the pancreatic 3 cell calcium: Electron spectroscopic imaging/electron Olof Larsson, Henrik Kindmark, Robert Branstrom, energy loss spectroscopy analysis of a Bertil Fredholm, and Per-Olof Berggren physically/chemically processed nerve -muscle preparation DEVELOPMENTAL BIOLOGY

Fabio Grohovaz, Mario Bossi, Roberta Pezzati, Jacopo Meldolesi, and Francesca Torni Tarelli Homologs of the Xenopus developmental gene DG42 4548-4553

are present in zebrafish and mouse and are involved Sensitivity and selectivity of the DNA damage sensor 4827-4832 in the synthesis of Nod-like chitin oligosaccharides responsible for activating p53-dependent G1 arrest during early embryogenesis

Li-chun Huang, Kristie C. Clarkin, Carlos B. Semino, Charles A. Specht, Alejandra and Geoffrey M. Wahl Raimondi, and Phillips W. Robbins

v



Contents

How cellular slime molds evade nematodes 4857-4861 DNA analysis and diagnostics on 4913-4918 Richard H. Kessin, Gregg G. Gundersen, Victor oligonucleotide microchips Zaydfudim, Mark Grimson, and R. Gennady Yershov, Victor Barsky, Alexander Lawrence Blanton Belgovskiy, Eugene Kirillov, Edward Kreindlin,

Igor Ivanov, Sergei Parinov, Dmitri Guschin, Mutagenesis and gene identification in Dictyostelium 5003-5007 Aleksei Drobishev, Svetlana Dubiley, by shotgun antisense and Andrei Mirzabekov

Timothy P. Spann, Debra A. Brock, David F. Lindsey, Salli A. Wood, and Richard H. Gomer Exchanges are not equally able to enhance meiotic 4979-4983

chromosome segregation in yeast ECOLOGY Lyle 0. Ross, Rebecca Maxfield, and Dean Dawson

Mapping leaf surface landscapes 4600-4603 Identification of functional domains and evolution of 5008-5013 Wendy L. Mechaber, Durwood B. Marshall, Tcl-like transposable elements Richard A. Mechaber, Renee T. Jobe, Zoltan Ivics, Zsuzsanna Izsvak, Adam Minter, and Frances S. Chew and Perry B. Hackett

Nest predation by cowbirds and its consequences for 4608-4611 Loss of tramtrack gene activity results in ectopic R7 5025-5030 passerine demography cell formation, even in a sina mutant background

Peter Arcese, James N. M. Smith, and Margret Zhi-Chun Lai, Stephen D. Harrison, Felix Karim, I. Hatch Ying Li, and Gerald M. Rubin

Why fisheries collapse and what to do about it 5078-5083 Jonathanfise Rougarden and Fraser Sm doaboutith

5078-5083 Two different but related mechanisms are used in 5055-5060 plants for the repair of genomic double-strand breaks by homologous recombination

EVOLUTION Holger Puchta, Bernard Dujon, and Barbara Hohn

The presence of codon-anticodon pairs in the 4537-4542 The impact of interindividual variation in NAT2 5084-5089 acceptor stem of tRNAs activity on benzidine urinary metabolites and

Sergei Rodin, Andrei Rodin, and Susumu Ohno urothelial DNA adducts in exposed workers

A general additive distance with time-reversibility and 4671-4676 N. Rothman, V. K. Bhatnagar, R. B. Hayes, T. V. rate variation among nucleotide sites Zenser, S. K. Kashyap, M. A. Butler, D. A. Bell, V.

Xun Gu and Wen-Hsiung Li Lakshmi, M. Jaeger, R. Kashyap, A. Hirvonen, P. A. Schulte, M. Dosemeci, F. Hsu, D. J. Parikh,

Ediacaran biota from Sonora, Mexico 4990-4993 B. B. Davis, and G. Talaska Mark A. S. McMenamin

Distribution of spontaneous plant hybrids 5090-5093 IMMUNOLOGY Norman C. Ellstrand, Richard Whitkus, and Loren H. Rieseberg Antigenic peptides containing large PEG loops 4583-4588

designed to extend out of the HLA-A2 binding site Ancient single origin for Malagasy primates 5122-5126 form stable complexes with class I major

Anne D. Yoder, Matt Cartmill, Maryellen Ruvolo, histabli complex cles Kathleen Smith, and Rytas Vilgalys Bouvier and Donec.ley

n ~~~~~~~~~~~~Marlene Bouvier and Don C. Wiley

Mitochondrial diversity and the origins of African and 5131-5135 Viral cross talk: Intracellular inactivation of the 4589-4594 European cattle

Daniel G. Bradley, David E. MacHugh, Patrick hepatitis B virus during an unrelated viral Cunningham, and Ronan T. Loftus infection of the liver

Luca G. Guidotti, Persephone Borrow, Monte V. Hobbs, Brent Matzke, Ion Gresser, Michael B. A.

GENETICS Oldstone, and Francis V. Chisari

Genomic structure of the human 4629-4632 Trafficking of Plasmodium chabaudi adami-infected 4595-4599 retinoblastoma-related Rb2/p130 gene erythrocytes within the mouse spleen

Alfonso Baldi, Vincenzo Boccia, Pier Paolo yaY Claudio, Antonio De Luca, and Antonio Giordano Anjaie Yadv, Sanj Kumar, JMies ' ' ~~~~~~~~~~~~~~Genevieve Milon, and Louis H. Miller

Genetic interactions among cytoplasmic dynein, 4775-4780 dynactin, and nuclear distribution mutants of Activated Ras signals differentiation and expansion of 4683-4687 Neurosporan cranssae CD4+8+ thymocytes

Kenneth S. Bruno, John H. Tinsley, Peter F. Minke, Wojciech Swat, Yoichi Shinkai, Hwei-Ling Cheng, and Michael Plamann Laurie Davidson, and Frederick W. Alt

Efficient transfer of genetic material into mammalian 4897-4902 Elevated interleukin 6 is induced by prostaglandin E2 4885-4890 cells using Starburst polyamidoamine dendrimers in a murine model of inflammation: Possible role of

Jolanta F. Kukowska-Latallo, Anna U. Bielinska, cyclooxygenase-2 Jennifer Johnson, Ralph Spindler, Donald A. Roger M. Hinson, Joy A. Williams, Tomalia, and James R. Baker, Jr. and Emily Shacter

V1



Contents

Induction of alloantigen-specific tolerance by B cells 4994-4998 Predominant role of a4-integrins for distinct steps of 4821-4826 from CD40-deficient mice lymphoma metastasis

Georg A. Hollander, Emanuela Castigli, Robert Uwe Gosslar, Petra Jonas, Arne Luz, Alexandra Kulbacki, Michael Su, Steven J. Burakoff, Lifka, David Naor, Alf Hamann, Jose-Carlos Gutierrez-Ramos, and Raif S. Geha and Bernhard Holzmann

Epitope-specific tolerance induction with an 5019-5024 Oligodeoxynucleotides inhibit retinal 4851-4856 engineered immunoglobulin neovascularization in a murine model of

Elias T. Zambidis and David W. Scott proliferative retinopathy Gregory S. Robinson, Eric A. Pierce, Susan L.

A synthetic random basic copolymer with promiscuous 5061-5066 Rook, Elliot Foley, Ruth Webb, and Lois binding to class II major histocompatibility complex E. H. Smith molecules inhibits T-cell proliferative responses to major and minor histocompatibility antigens in vitro An increased risk of Crohn's disease in individuals 5094-5098 and confers the capacity to prevent murine who inherit the HLA class II DRB3*030] allele graft-versus-host disease in vivo David G. Forcione, Bruce Sands, Kurt J.

Paul G. Schlegel, Rina Aharoni, Yanfei Chen, Jun Isselbacher, Anil Rustgi, Daniel K. Podolsky, Chen, Dvora Teitelbaum, Ruth Arnon, Michael and Shiv Pillai Sela, and Nelson J. Chao

Fluorescent light-induced chromatid breaks distinguish 5146-5150

Human V82+ y8 T-cell tolerance to foreign antigens 5136-5140 Alzheimer disease cells from normal cells in

of Toxoplasma gondii tissue culture Ram Parshad, Katherine K. Sanford, Floyd M.

Toshiro Ara, Hizk Hashi, Yushir Yamaht, Price, Lynn K. Melnick, Linda B. Nee, Mark B.

Toshia k. Abe, ajm He dak unisk Schapiro, Robert E. Tarone, and Jay H. Robbins Robert A. Good, and Kenzo Takeshita

Preferential induction of a Thl immune response and 5141-5145 MICROBIOLOGY inhibition of specific zgE antibon y formation by Signal transduction in the Archaeon Halobacterium 4649-4654

yal Raz, Helen Tighe, Yukio Sato, Maripat Corro salinarium is processed through three subfamilies of Jean A. Dudler, Mark Roman, Susan L. Swain, 13 soluble and membrane-bound transducer proteins Heans L. Dpiglberg, Mand annSsa

. waron, Weisheng Zhang, Alexei Brooun, Jacqueline McCandless, Phillip Banda, and Maqsudul Alam

MEDICAL SCIENCES Bcl-2 protects mice against fatal 4810-4815 alphavirus encephalitis

Beth Levine, James B. Goldman, Hui Hui Jiang, Excitotoxicity in the lung: N-Methyl-D-aspartate- 4688-4692 Dian .Giin, and J. mari Ha ick induced, nitric oxide-dependent, pulmonary edema is attenuated by vasoactive intestinal peptide and by Expression of transduced genes in mice generated by 4931-4936 inhibitors of poly(ADP-ribose) polymerase infecting blastocysts with avian leukosis virus-based

Sami I. Said, Hasan I. Berisha, retroviral vectors and Hedayatollah Pakbaz Mark J. Federspiel, Deborah A. Swing, Bryn

Eagleson, Susan W. Reid, and Stephen H. Hughes The control of hematopoiesis and leukemia: From 4742-4749 basic biology to the clinic Oxidative stress is involved in heat-induced cell death 5116-5121

Leo Sachs in Saccharomyces cerevisiae John F. Davidson, Brett Whyte, Peter H. Bissinger,

p53 as a target for cancer vaccines: Recombinant 4781-4786 and Robert H. Schiestl canarypox virus vectors expressing p53 protect mice against lethal tumor cell challenge NEUROBIOLOGY

Judith Roth, Dirk Dittmer, Delphine Rea, James Tartaglia, Enzo Paoletti, and Arnold J. Levine Role of neuronal nitric oxide in 1-methyl-4-phenyl- 4565-4571

1,2,3,6-tetrahydropyridine (MPTP)-induced The t(10;11)(pl3;ql4) in the U937 cell line results in 4804-4809 dopaminergic neurotoxicity the fusion of the AFJO gene and CALM, encoding a Serge Przedborski, Vernice Jackson-Lewis, Rina new member of the AP-3 clathrin assembly Yokoyama, Toshihiro Shibata, Valina L. Dawson, protein family and Ted M. Dawson

M. H. Dreyling, J. A. Martinez-Climent, M. Zheng, J. Mao, J. D. Rowley, and S. K. Bohlander A circadian clock regulates rod and cone input to fish 4655-4660

retinal cone horizontal cells Prostaglandin H synthase 2 is expressed abnormally in 4816-4820 Yu Wang and Stuart C. Mangel human colon cancer: Evidence for a transcriptional effect Cloning and functional expression of cDNAs encoding 4661-4665

William Kutchera, David A. Jones, Norisada human and rat pancreatic polypeptide receptors Matsunami, Joanna Groden, Thomas M. McIntyre, Hai Yan, Jie Yang, Julie Marasco, Kumiko Guy A. Zimmerman, Raymond L. White, Yamaguchi, Sydney Brenner, Frank Collins, and Stephen M. Prescott and William Karbon

Vll



Contents

Reconstitution of the hippocampal mossy fiber and 4706-4711 Distinct pharmacological properties and distribution 5166-5171 associational-commissural pathways in a novel in neurons and endocrine cells of two isoforms of the dissociated cell culture system human vesicular monoamine transporter

Danny Baranes, Juan Carlos L6pez-Garcia, Mary Jeffrey D. Erickson, Martin K.-H. Schafer, Tom I. Chen, Craig H. Bailey, and Eric R. Kandel Bonner, Lee E. Eiden, and Eberhard Weihe

A presynaptic locus for long-term potentiation of 4712-4717 PHARMACOLOGY elementary synaptic transmission at mossy fiber syementapsesyinapcul ture

nsmission atmossyfiber Polynitrosylated proteins: Characterization, bioactivity, 4736-4741 synapses in culture ~~~~~~~~and functional consequences Juan Carlos L6pez-Garcia, Ottavio Arancio, Eric R. andefncionlmonsequEnces ' ' ~~~~~~~~~~Daniel I. Simon, Mark E. Mullins, Li Jia, Ben

Kandel, and Danny Baranes Gaston, David J. Singel, and Jonathan S. Stamler Behavioral stress modifies hippocampal plasticity 4750-4753 4-Oxoretinol, a new natural ligand and transactivator 4879-4884 through N-methyl-D-aspartate receptor activation of the retinoic acid receptors

Jeansok J. Kim, Michael R. Foy, and Richard Charles C. Achkar, Fadila Derguini, Bruce F. Thompson Blumberg, Alexander Langston, Arthur A. Levin,

Jeffrey Speck, Ronald M. Evans, Jack Bolado, Jr., Synaptophysln, a major synaptic veslcle protein, iS not 4760-4764 Koji Nakanishi, Jochen Buck, and Lorraine essential for neurotransmitter release J. Gudas

Harvey T. McMahon, Vadim Y. Bolshakov, Roger Janz, Robert E. Hammer, Steven A. Siegelbaum, PHYSIOLOGY and Thomas C. Sudhof

In vivo suppression of the renal Na+/Pi cotransporter 4903-4906 Age-related losses of cognitive function and motor 4765-4769 by antisense oligonucleotides skills in mice are associated with oxidative protein Rainer Oberbauer, George F. Schreiner, Jurg Biber, damage in the brain Heini Murer, and Timothy W. Meyer

Michael J. Forster, Anju Dubey, Kimberly M. Hemodynamic effects of epidermal growth factor in 4957-4961 Dawson, William A. Stutts, Harbans Lal, conscious rats and monkeys

and Rajindar S. Sohal Joan A. Keiser and Michael J. Ryan Selective attention to stimulus location modulates the 4770-4774 steady-state visual evoked potential PLANT BIOLOGY

S. T. Morgan, J. C. Hansen, and S. A. Hillyard Arabidopsis mutant analysis and gene regulation 4718-4723 define a nonredundant role for glutamate

Neuregulins with an Ig-like domain are essential for 4833-4838 dehree i n itrogen assimiati mouse myocardial and neuronal development Rosana Melo-Oliveira, Igor Cunha Oliveira,

Rainer Kramer, Nathan Bucay, Darci J. Kane, and Gloria M. Coruzzi Laura E. Martin, John E. Tarpley, and Lars E. Theill Dimerization specificity of Arabidopsis MADS domain 4793-4798

homeotic proteins APETALAI, APETALA3, Huntingtin-associated protein (HAP1): Discrete 4839-4844 PISTILLATA, and AGAMOUS neuronal localizations in the brain resemble those of Jose Luis Riechmann, Beth Allyn Krizek, neuronal nitric oxide synthase and Elliot M. Meyerowitz

Xiao-Jiang Li, Alan H. Sharp, Shi-Hua Li, Ted M. XiawsoJiang Li,Alo n H. Snyerp, andSChi ai,stoped MOzone-induced responses in Arabidopsis thaliana: The 5099-5104 Dawson, Solomon H. Snyder, and Christopher role of salicylic acid in the accumulation of A. Ross

defense-related transcripts and induced resistance Quantitative long-term imaging of the functional 4942-4947 Yogesh K. Sharma, Jose Le6n, Ilya Raskin, representation of a whisker in rat barrel cortex and Keith R. Davis

S. A. Masino and R. D. Frostig

Electrical microstimulation suggests two different 4962-4967 Social Sciences forms of representation of head-centered space in the ANTHROPOLOGY intraparietal sulcus of rhesus monkeys

P. Thier and R. A. Andersen Culture as shared cognitive representations 4699-4705 A. Kimball Romney, John P. Boyd, Carmella C.

Expansion of polyglutamine repeat in huntingtin leads 5037-5042 Moore, William H. Batchelder, and Timothy to abnormal protein interactions involving calmodulin J. Brazill

Jun Bao, Alan H. Sharp, Molly V. Wagster, Mark Becher, Gabriele Schilling, Christopher A. Ross, Mitochondrial diversity and the origins of African and 5131-5135 Valina L. Dawson, and Ted M. Dawson European cattle

Daniel G. Bradley, David E. MacHugh, Patrick Low ethanol concentrations enhance GABAergic 5049-5054 Cunningham, and Ronan T. Loftus inhibitory postsynaptic potentials in hippocampal pyramidal neurons only after block of PSYCHOLOGY GABAB receptors Hippocampal acetylcholine release during memory 4693-4698

Fang-.Jung Wan, Fulvia Berton, Samuel G. testing in rats: Augmentation by glucose Madamba, Walter Francesconi, and George Michael E. Ragozzino, Katharine E. Unick, Robert Siggins and Paul E. Gold

Spatial localization of calcium channels in giant fiber 5067-5071 Selective attention to stimulus location modulates the 4770-4774 lobe neurons of the squid (Loligo opalescens) steady-state visual evoked potential

Matthew B. McFarlane and William F. Gilly S. T. Morgan, J. C. Hansen, and S. A. Hillyard

.v.i.



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