Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 93, No. 24 (Nov. 26, 1996), pp. i-xiiPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/40918 .
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PROCEEDINGS
OF THE
NATIONAL ACADEMY OF SCIENCES
OF THE UNITED STATES OF AMERICA
November 26, 1996
Volume 93 / Number 24
INCLUDES: PAPERS FROM A NATIONAL ACADEMY OF SCIENCES COLLOQUIUM ON MEMORY: RECORDING EXPERIENCE IN CELLS AND CIRCUITS
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1 2 3 4 5 67 8 9 10 0PharMingen now offers antibodies against the following apoptosis associated proteins:
Z ~~~~M onoclonal antibodies to human and mouse Fas and Fas Ligand now available!
*Bad Ich-I aCD3 10 GtiB Bak *Mci-I CDw7O
Flurecence ntnsty Bax *Nur77 aOX-40 * Bcl-2 * PARP * 4-I BB
0 Bcl-x 0 ~~RIP * ~~~~~~~~~For measuring apoptosis, we now offer the
APO-DIECT'-7 * kit, a system for single step detection of apoptotic cells by flow cytometry.
* ~~Visit us on the Web!
r4 -a ~http://www.pharmingen.com 107ToranRad4 To place an order call: Figure A: Figure A. DNA tragmentation induced by anti-mouse Fas mAb, (80 4M B 62) Sani Diego, CA 92121 Clone Jo2 (Cat # 15400D). A28 cells were incubated at 37 degrees C with For technical assistance call: [el: (619) 812-88100 Sng (4.~8).~ 25 ng (5.9) or SO ng/mi1 (6.10) ot anti-Fas tori1 hr (4-6) or 2 h rs (7- 10). Negative and isotype controls included A28 cells incubated without anti- (800) TALK-TEC (825-5832) v:ax: (619) 812-8888 PHAIIMINGI:N body (2) and with 50 ng/ml hamster lgG (3 [1 hr],7 [2 hr]). respectively ). DNA
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PRO CEED INGS
OF THE
NATIONAL ACADEMY OF SCIENCES
OF THE UNITED STATES OF AMERICA
November 26, 1996 Volume 93, Number 24 pp. 13435-14214
Table of Contents
Papers from a National Academy of Sciences Colloquium on Memory: Recording Experience in Cells and Circuits
Memory: Recording experience in cells and circuits: 13435-13437 Diversity in memory research
Patricia S. Goldman-Rakic
Memory systems in the brain and localization of 13438-13444 a memory
Richard F. Thompson and Jeansok J. Kim
Toward a molecular definition of long-term 13445-13452 memory storage
Craig H. Bailey, Dusan Bartsch, and Eric R. Kandel
A synaptic basis for memory storage in the 13453-13459 cerebral cortex
Mark F. Bear
Discovery of genes involved with learning and 13460-13467 memory: An experimental synthesis of Hirschian and Benzerian perspectives
Tim Tully
The fractionation of working memory 13468-13472 Alan Baddeley
Regional and cellular fractionation of 13473-13480 working memory
Patricia S. Goldman-Rakic
Memory from the dynamics of intrinsic 13481-13486 membrane currents
Eve Marder, L. F. Abbott, Gina G. Turrigiano, Zheng Liu, and Jorge Golowasch
Ensemble codes involving hippocampal neurons are 13487-13493 at risk during delayed performance tests
Robert E. Hampson and Sam A. Deadwyler
Neural mechanisms for visual memory and their role 13494-13499 in attention
Robert Desimone
Functional organization of the hippocampal 13500-13507 memory system
Howard Eichenbaum, Geoffrey Schoenbaum, Brian Young, and Michael Bunsey
Involvement of the amygdala in memory storage: 13508-13514 Interaction with other brain systems
James L. McGaugh, Larry Cahill, and Benno Roozendaal
Structure and function of declarative and 13515-13522 nondeclarative memory systems
Larry R. Squire and Stuart M. Zola
v
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Contents
Studies of retrograde memory: A long-term view 13523-13526 Elizabeth K. Warrington
Illusory memories: A cognitive neuroscience analysis 13527-13533 Daniel L. Schacter
Memory systems analyses of mnemonic disorders in 13534-13540 aging and age-related diseases
John D. E. Gabrieli
Muscarinic acetylcholine receptor expression in 13541-13546 memory circuits: Implications for treatment of Alzheimer disease
Allan I. Levey
Cognitive and neurobiologic markers of early 13547-13551 Alzheimer disease
Marilyn S. Albert
Commentary
Twinkle, twinkle little StAR, how we wonder what 13552-13554 you are
Ronald W. Estabrook and William E. Rainey
Inaugural Papers
YY1 transcriptional initiator: Protein interactions 13571-13576 and association with a DNA site containing unpaired strands
Anny Usheva and Thomas Shenk
The structural H19 gene is required for 13876-13883 transgene imprinting
Karl Pfeifer, Philip A. Leighton, and Shirley M. Tilghman
Physical Sciences
APPLIED PHYSICAL SCIENCES
Light-directed synthesis of high-density 13555-13560 oligonucleotide arrays using semiconductor photoresists
Glenn McGall, Jeff Labadie, Phil Brock, Greg Wallraff, Tien Nguyen, and William Hinsberg
Time-resolved optical diffusion tomographic image 13561-13564 reconstruction in highly scattering turbid media
W. Cai, B. B. Das, Feng Liu, M. Zevallos, M. Lax, and R. R. Alfano
Biological Sciences
APPLIED BIOLOGICAL SCIENCES
A helper-dependent adenovirus vector system: 13565-13570 Removal of helper virus by Cre-mediated excision of the viral packaging signal
Robin J. Parks, Liane Chen, Martina Anton, Uma Sankar, Michael A. Rudnicki, and Frank L. Graham
BIOCHEMISTRY
YY1 transcriptional initiator: Protein interactions 13571-13576 and association with a DNA site containing unpaired strands
Anny Usheva and Thomas Shenk
Cocrystal structure of YY1 bound to the 13577-13582 adeno-associated virus P5 initiator
Hristo B. Houbaviy, Anny Usheva, Thomas Shenk, and Stephen K. Burley
A small engineered protein lacks structural 13583-13588 uniqueness by increasing the side-chain conformational entropy
Koji Furukawa, Masayuki Oda, and Haruki Nakamura
Crystal structure of the secretory form of 13589-13594 membrane-associated human carbonic anhydrase IV at 2.8-A resolution
Travis Stams, Satish K. Nair, Torayuki Okuyama, Abdul Waheed, William S. Sly, and David W. Christianson
Evidence for a transcriptional activation function of 13595-13599 BRCA1 C-terminal region
Alvaro N. A. Monteiro, Avery August, and Hidesaburo Hanafusa
Sucrose biosynthesis in a prokaryotic organism: 13600-13604 Presence of two sucrose-phosphate synthases in Anabaena with remarkable differences compared with the plant enzymes
Andrea C. Porchia and Graciela L. Salerno
The role of apolipoprotein Al domains in 13605-13610 lipid binding
W. Sean Davidson, Theodore Hazlett, William W. Mantulin, and Ana Jonas
Molecular cloning and analysis of two subunits 13611-13616 of the human TFIID complex: hTAF11130 and hTAFII100
Naoko Tanese, Daman Saluja, Milo F. Vassallo, Jin-Long Chen, and Arie Admon
Chemical nature of the light emitter of the Aequorea 13617-13622 green fluorescent protein
Haruki Niwa, Satoshi Inouye, Takashi Hirano, Tatsuki Matsuno, Satoshi Kojima, Masayuki Kubota, Mamoru Ohashi, and Frederick I. Tsuji
PCR-based development of DNA substrates 13623-13628 containing modified bases: An efficient system for investigating the role of the exocyclic groups in chemical and structural recognition by minor groove binding drugs and proteins
Christian Bailly, Dominique Payet, Andrew A. Travers, and Michael J. Waring
hMSH2 forms specific mispair-binding complexes 13629-13634 with hMSH3 and hMSH6
Samir Acharya, Teresa Wilson, Scott Gradia, Michael F. Kane, Shawn Guerrette, Gerald T. Marsischky, Richard Kolodner, and Richard Fishel
vi
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Contents
Superoxide accelerates DNA damage by elevating 13635-13640 free-iron levels
Kay Keyer and James A. Imlay
The essential yeast RNA binding protein 13641-13646 Npl3p is methylated
Christian W. Siebel and Christine Guthrie
Gly-63 -> Gln substitution adjacent to His-64 in 13647-13652 rodent carbonic anhydrase IVs largely explains their reduced activity
Shinya Tamai, Abdul Waheed, Lee B. Cody, and William S. Sly
Pepsin-inhibitory activity of the uterine serpins 13653-13658 Nagappan Mathialagan and Thomas R. Hansen
Zinc folds the N-terminal domain of HIV-1 13659-13664 integrase, promotes multimerization, and enhances catalytic activity
Ronglan Zheng, Timothy M. Jenkins, and Robert Craigie
Energy considerations show that low-barrier 13665-13670 hydrogen bonds do not offer a catalytic advantage over ordinary hydrogen bonds
Arieh Warshel and Arno Papazyan
A critical arginine residue mediates cooperativity in 13671-13676 the contact interface between transcription factors NFAT and AP-1
Blake R. Peterson, Li Jing Sun, and Gregory L. Verdine
Fidelity of RNA polymerase II transcription 13677-13682 controlled by elongation factor TFIIS
ChoonJu Jeon and Kan Agarwal
A peroxidase related to the mammalian antimicrobial 13683-13688 protein myeloperoxidase in the Euprymna- Vibrio mutualism
Virginia M. Weis, Andrea L. Srnall, and Margaret J. McFall-Ngai
Elimination of the Chlamydomonas gene family that 13689-13693 encodes the small subunit of ribulose-1,5- bisphosphate carboxylase/oxygenase
Irina Khrebtukova and Robert J. Spreitzer
A Drosophila gene structurally and functionally 13694-13698 homologous to the mammalian 70-kDa S6 kinase gene
Kellie L. Watson, Margaret M. Chou, John Blenis, William M. Gelbart, and Raymond L. Erikson
The reaction of fluorocitrate with aconitase 13699-13703 and the crystal structure of the enzyme- inhibitor complex
H. Lauble, M. C. Kennedy, M. H. Emptage, H. Beinert, and C. D. Stout
In vitro activation of Stat3 by epidermal growth 13704-13708 factor receptor kinase
Ohkmae K. Park, Timothy S. Schaefer, and Daniel Nathans
Recurrent G-to-A substitution in a single codon of 13709-13714 SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines
Axel Nohturfft, Xianxin Hua, Michael S. Brown, and Joseph L. Goldstein
Melanotropic peptide-conjugated beads for 13715-13720 microscopic visualization and characterization of melanoma melanotropin receptors
Shubh D. Sharma, Jinwen Jiang, Mac E. Hadley, David L. Bentley, and Victor J. Hruby
A cytokine mRNA-destabilizing element that is 13721-13725 structurally and functionally distinct from A+U-rich elements
Cheryl Y. Brown, Cathy A. Lagnado, and Gregory J. Goodall
Defective subunit assembly underlies a digenic form 13726-13730 of retinitis pigmentosa linked to mutations in peripherin/rds and rom-1
Andrew F. X. Goldberg and Robert S. Molday
Steroidogenic acute regulatory protein (StAR) retains 13731-13736 activity in the absence of its mitochondrial import sequence: Implications for the mechanism of StAR action
Futoshi Arakane, Teruo Sugawara, Hideaki Nishino, Zhiming Liu, John A. Holt, Debkumar Pain, Douglas M. Stocco, Walter L. Miller, and Jerome F. Strauss, III
An unusual mechanism for the major human 13737-13741 apurinic/apyrimidinic (AP) endonuclease involving 5' cleavage of DNA containing a benzene-derived exocyclic adduct in the absence of an AP site
B. Hang, A. Chenna, H. Fraenkel-Conrat, and B. Singer
Involvement of the cyclin-dependent kinase inhibitor 13742-13747 p16 (INK4a) in replicative senescence of normal human fibroblasts
David A. Alcorta, Yue Xiong, Dawn Phelps, Greg Hannon, David Beach, and J. Carl Barrett
Molecular characterization of the human peroxisomal 13748-13753 branched-chain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger syndrome
Eveline Baumgart, Johannes C. T. Vanhooren, Mark Fransen, Peter Marynen, Magda Puype, Joel Vandekerckhove, Jack A. M. Leunissen, H. Dariush Fahimi, Guy P. Mannaerts, and Paul P. Van Veldhoven
Metal binding properties and secondary structure of 13754-13759 the zinc-binding domain of Nup475
Mark T. Worthington, Barbara T. Amann, Daniel Nathans, and Jeremy M. Berg
The Saccharomyces CDC13 protein is a single-strand 13760-13765 TG1_3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo
Jing-Jer Lin and Virginia A. Zakian
vii
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Contents
Fork-like DNA templates support bypass replication 13766-13769 of lesions that block DNA synthesis on single-stranded templates
Jean-Sebastien Hoffmann, Marie-Jeanne Pillaire, Claire Lesca, Dominique Burnouf, Robert P. P. Fuchs, Martine Defais, and Giuseppe Villani
BIOPHYSICS
Characterization of individual polynucleotide 13770-13773 molecules using a membrane channel
John J. Kasianowicz, Eric Brandin, Daniel Branton, and David W. Deamer
Ultrafast exciton relaxation in the B850 antenna 13774-13779 complex of Rhodobacter sphaeroides
V. Nagarajan, R. G. Alden, J. C. Williams, and W. W. Parson
CELL BIOLOGY
TOR2 is required for organization of the actin 13780-13785 cytoskeleton in yeast
Anja Schmidt, Jeannette Kunz, and Michael N. Hall
Inhibition of interleukin 1/3-converting 13786-13790 enzyme-mediated apoptosis of mammalian cells by baculovirus IAP
Christine J. Hawkins, Anthony G. Uren, Georg Hacker, Robert L. Medcalf, and David L. Vaux
Interferon-inducible protein-10 identified as a 13791-13796 mediator of tumor necrosis in vivo
Cecilia Sgadari, Anne L. Angiolillo, Barry W. Cherney, Sandra E. Pike, Joshua M. Farber, Leonidas G. Koniaris, Padmavathy Vanguri, Parris R. Burd, Nasreen Sheikh, Ghanshyam Gupta, Julie Teruya-Feldstein, and Giovanna Tosato
Proteasome-dependent endoplasmic 13797-13801 reticulum-associated protein degradation: An unconventional route to a familiar fate
Eric D. Werner, Jeffrey L. Brodsky, and Ardythe A. McCracken
The highly conserved skbl gene encodes a protein 13802-13807 that interacts with Shkl, a fission yeast Ste20/PAK homolog
Mary Gilbreth, Peirong Yang, Dan Wang, Jeff Frost, Anthony Polverino, Melanie H. Cobb, and Stevan Marcus
Calexcitin: A signaling protein that binds 13808-13813 calcium and GTP, inhibits potassium channels, and enhances membrane excitability
Thomas J. Nelson, Sebastiano Cavallaro, Chu-Li Yi, Donna McPhie, Bernard G. Schreurs, Pavel A. Gusev, Antonella Favit, Ofer Zohar, Jeongho Kim, Sven Beushausen, Giorgio Ascoli, James Olds, Rachael Neve, and Daniel L. Alkon
Involvement of stress-activated protein kinase and 13814-13818 p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes
J. D. Graves, K. E. Draves, A. Craxton, J. Saklatvala, E. G. Krebs, and E. A. Clark
Multiple A-type cyclins express sequentially 13819-13824 during the cell cycle in Nicotiana tabacum BY2 cells
Jean-Philippe Reichheld, Nicole Chaubet, Wen Hui Shen, Jean-Pierre Renaudin, and Claude Gigot
The DNA damage response in DNA-dependent 13825-13830 protein kinase-deficient SCID mouse cells: Replication protein A hyperphosphorylation and p53 induction
Laura M. Fried, Constantinos Koumenis, Scott R. Peterson, Susannah L. Green, Pierre van Zijl, Joan Allalunis-Turner, David J. Chen, Richard Fishel, Amato J. Giaccia, J. Martin Brown, and Cordula U. Kirchgessner
DEVELOPMENTAL BIOLOGY
Flowers into shoots: Photo and hormonal control 13831-13836 of a meristem identity switch in Arabidopsis
Jack K. Okamuro, Bart G. W. den Boer, Cynthia Lotys-Prass, Wayne Szeto, and K. Diane Jofuku
Multiple potential germ-line helicases are components 13837-13842 of the germ-line-specific P granules of Caenorhabditis elegans
M. E. Gruidl, P. A. Smith, K. A. Kuznicki, J. S. McCrone, J. Kirchner, D. L. Roussell, S. Strome, and K. L. Bennett
Blockade of plasma membrane calcium pumping 13843-13848 ATPase isoform I impairs nerve growth factor-induced neurite extension in pheochromocytoma cells
Paul C. Brandt, Jesse E. Sisken, Rachael L. Neve, and Thomas C. Vanaman
Developmental expression of synthetic cis-regulatory 13849-13854 systems composed of spatial control elements from two different genes
Carmen V. Kirchhamer, Leonard D. Bogarad, and Eric H. Davidson
ECOLOGY
Effects of productivity, consumers, competitors, and 13855-13858 El Niho events on food chain patterns in a rocky intertidal community
J. T. Wootton, M. E. Power, R. T. Paine, and C. A. Pfister
EVOLUTION
Misconceptions about mitochondria and mammalian 13859-13863 fertilization: Implications for theories on human evolution
Friderun AnkebSimons and Jim M. CLtmmins
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Contents
GENETICS
Dimerization of Ste5, a mitogen-activated protein 13864-13869 kinase cascade scaffold protein, is required for signal transduction
Deborah Yablonski, Irit Marbach, and Alexander Levitzki
The mouse Pax2lNeu mutation is identical to a 13870-13875 human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney
Jack Favor, Rodica Sandulache, Angelika Neuhauser-Klaus, Walter Pretsch, Bimal Chatterjee, Elfriede Senft, Wolfgang Wurst, Veronique Blanquet, Patricia Grimes, Ralf Sp6rle, and Klaus Schughart
The structural H19 gene is required for 13876-13883 transgene imprinting
Karl Pfeifer, Philip A. Leighton, and Shirley M. Tilghman
Intron of the mouse Hoxa-7 gene contains conserved 13884-13889 homeodomain binding sites that can function as an enhancer element in Drosophila
Theodor E. Haerry and Walter J. Gehring
A human homolog of the Schizosaccharomyces pombe 13890-13895 rad9+ checkpoint control gene
Howard B. Lieberman, Kevin M. Hopkins, Monica Nass, Douglas Demetrick, and Scott Davey
A positive genetic selection for disrupting 13896-13901 protein-protein interactions: Identification of CREB mutations that prevent association with the coactivator CBP
Hsiu-ming Shih, Phyllis S. Goldman, Anthony J. DeMaggio, Stanley M. Hollenberg, Richard H. Goodman, and Merl F. Hoekstra
Cell cycle-regulated generation of single-stranded 13902-13907 G-rich DNA in the absence of telomerase
Isabelle Dionne and Raymund J. Wellinger
A procedure for the prediction of 13908-13913 temperature-sensitive mutants of a globular protein based solely on the amino acid sequence
R. Varadarajan, H. A. Nagarajaram, and C. Ramakrishnan
An upstream activator of transcription coordinately 13914-13918 increases the level and epigenetic stability of gene expression
Wendy Magis, Steven Fiering, Mark Groudine, and David I. K. Martin
Transcription-induced mutations: Increase in C to T 13919-13924 mutations in the nontranscribed strand during transcription in Escherichia coli
A. Beletskii and Ashok S. Bhagwat
Highly selective isolation of human DNAs from 13925-13930 rodent-human hybrid cells as circular yeast artificial chromosomes by transformation-associated recombination cloning
Vladimir Larionov, Natalya Kouprina, Joan Graves, and Michael A. Resnick
Promiscuous translocations into immunoglobulin 13931-13936 heavy chain switch regions in multiple myeloma
P. Leif Bergsagel, Marta Chesi, Elena Nardini, Leslie A. Brents, Suzanne L. Kirby, and W. Michael Kuehl
Two eukaryote-specific regions of Hsp82 are 13937-13942 dispensable for its viability and signal transduction functions in yeast
Jean-Frangois Louvion, Rainer Warth, and Didier Picard
NRF2, a member of the NFE2 family of transcription 13943-13948 factors, is not essential for murine erythropoiesis, growth, and development
Kaimin Chan, Ronghua Lu, Judy C. Chang, and Yuet Wai Kan
Lack of chromosome territoriality in yeast: 13949-13954 Promiscuous rejoining of broken chromosome ends
James E. Haber and Wai-Ying Leung
myb provides an essential function during 13955-13960 Drosophila development
Alisa L. Katzen and J. Michael Bishop
Absence of the /3 subunit (cchbl) of the skeletal 13961-13966 muscle dihydropyridine receptor alters expression of the a, subunit and eliminates excitation- contraction coupling
Ronald G. Gregg, Albee Messing, Caroline Strube, Maryline Beurg, Richard Moss, Mary Behan, Manana Sukhareva, Susan Haynes, Jeanne A. Powell, Roberto Coronado, and Patricia A. Powers
IMMUNOLOGY
Costimulatory function and expression of CD40 13967-13972 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection
Wayne W. Hancock, Mohamed H. Sayegh, Xiang-Guang Zheng, Robert Peach, Peter S. Linsley, and Laurence A. Turka
The tumor necrosis factor receptor 2 signal 13973-13978 transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex
Hong-Bing Shu, Masahiro Takeuchi, and David V. Goeddel
Modifying the sequence of an immunoglobulin 13979-13984 V-gene alters the resulting pattern of hypermutation
Beatriz Goyenechea and Cesar Milstein
Role of p300-family proteins in EIA oncogene 13985-13990 induction of cytolytic susceptibility and tumor cell rejection
James L. Cook, Carol K. Krantz, and Barbara A. Routes
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Contents
The mouse mammary tumor virus env gene is the 13991-13996 source of a CD8+ T-cell-stimulating peptide presented by a major histocompatibility complex class I molecule in a murine thymoma
Subramaniam Malarkannan, Thomas Serwold, Vu Nguyen, Linda A. Sherman, and Nilabh Shastri
Deglucosylation of N-linked glycans is an important 13997-14001 step in the dissociation of calreticulin-class I-TAP complexes
Jeroen E. M. Van Leeuwen and Kelly P. Kearse
A functional interleukin 12 receptor complex is 14002-14007 composed of two /3-type cytokine receptor subunits
David H. Presky, Hong Yang, Lisa J. Minetti, Anne 0. Chua, Nasrin Nabavi, Chang-You Wu, Maurice K. Gately, and Ueli Gubler
In vitro V(D)J recombination: Signal joint formation 14008-14013 Patricia Cortes, Frances Weis-Garcia, Ziva Misulovin, Andre Nussenzweig, Jiann-Shiun Lai, Gloria Li, Michel C. Nussenzweig, and David Baltimore
MEDICAL SCIENCES
A novel mechanism of action of tetracyclines: Effects 14014-14019 on nitric oxide synthases
Ashok R. Amin, Mukundan G. Attur, Geeta D. Thakker, Prakash D. Patel, Pranav R. Vyas, Rajesh N. Patel, Indravadan R. Patel, and Steven B. Abramson
In situ hybridization analysis of presenilin 14020-14024 1 mRNA in Alzheimer disease and in lesioned rat brain
Keith Page, Richard Hollister, Rudolph E. Tanzi, and Bradley T. Hyman
Frequent clones of p53-mutated keratinocytes in 14025-14029 normal human skin
Alan S. Jonason, Subrahmanyam Kunala, Gary J. Price, Richard J. Restifo, Henry M. Spinelli, John A. Persing, David J. Leffell, Robert E. Tarone, and Douglas E. Brash
Biochemical characterization and intracellular 14030-14035 localization of the Menkes disease protein
Yukitoshi Yamaguchi, Mark E. Heiny, Mariko Suzuki, and Jonathan D. Gitlin
Ribonucleotide reductase R2 component is a novel 14036-14040 malignancy determinant that cooperates with activated oncogenes to determine transformation and malignant potential
Huizhou Fan, Cristy Villegas, and Jim A. Wright
Disruption of the acyl-CoA:cholesterol acyltransferase 14041-14046 gene in mice: Evidence suggesting multiple cholesterol esterification enzymes in mammals
Vardiella L. Meiner, Sylvaine Cases, Heather M. Myers, Eric R. Sande, Stefano Bellost a, Morris Schamb elan, Robert E. Pitas, James McGuire, Joachim Herz, and Robert V. Farese, Jr.
Tumor progression to the metastatic state involves 14047-14052 structural modifications in DNA markedly different from those associated with primary tumor formation
Donald C. Malins, Nayak L. Polissar, and Sandra J. Gunselman
Tumor necrosis factor receptor-associated factor 14053-14058 (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation
Stephane Ansieau, Inka Scheffrahn, George Mosialos, Heike Brand, Justus Duyster, Kenneth Kaye, Josephine Harada, Bill Dougall, Gabi Hubinger, Elliott Kieff, Friedhelm Herrmann, Achim Leutz, and Hans-Jurgen Gruss
The AMLI/ETO fusion protein activates 14059-14064 transcription of BCL-2
Lidija Klampfer, Jin Zhang, Andrew 0. Zelenetz, Hideo Uchida, and Stephen D. Nimer
Brain monoamine oxidase A inhibition in 14065-14069 cigarette smokers
Joanna S. Fowler, Nora D. Volkow, Gene-Jack Wang, Naomi Pappas, Jean Logan, Colleen Shea, David Alexoff, Robert R. MacGregor, David J. Schlyer, Ivana Zezulkova, and Alfred P. Wolf
Efficient gene transfer by a human immunodeficiency 14070-14075 virus type 1 (HIV-1)-derived vector utilizing a stable HIV packaging cell line
Pierre Corbeau, Gunter Kraus, and Flossie Wong-Staal
HIV replication in CD4+ T cells of HIV-infected 14076-14081 individuals is regulated by a balance between the viral suppressive effects of endogenous /3-chemokines and the viral inductive effects of other endogenous cytokines
Audrey L. Kinter, Mario Ostrowski, Delia Goletti, Alessandra Oliva, Drew Weissman, Kira Gantt, Elena Hardy, Robert Jackson, Linda Ehler, and Anthony S. Fauci
Gene delivery to skeletal muscle results in sustained 14082-14087 expression and systemic delivery of a therapeutic protein
Paul D. Kessler, Gregory M. Podsakoff, Xiaojuan Chen, Susan A. McQuiston, Peter C. Colosi, Laura A. Matelis, Gary J. Kurtzman, and Barry J. Byrne
Retroviral transduction of a mutant methylguanine 14088-14093 DNA methyltransferase gene into human CD34 cells confers resistance to 06-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea
Jane S. Reese, Omer N. KoW, Keun Myoung Lee, Lili Liu, James A. Allay, Weldon P. Phillips, Jr., and Stanton L. Gerson
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Contents
BAX enhances paclitaxel-induced apoptosis through 14094-14099 a p53-independent pathway
Thomas Strobel, Linda Swanson, Stanley Korsmeyer, and Stephen A. Cannistra
Older males secrete luteinizing hormone and 14100-14105 testosterone more irregularly, and jointly more asynchronously, than younger males
Steven M. Pincus, Thomas Mulligan, Ali Iranmanesh, Sylvia Gheorghiu, Michael Godschalk, and Johannes D. Veldhuis
The tumorigenic potential and cell growth 14106-14111 characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2
Stephen N. Jones, Arthur T. Sands, Amy R. Hancock, Hannes Vogel, Lawrence A. Donehower, Steven P. Linke, Geoffrey M. Wahl, and Allan Bradley
Diazepam binding inhibitor is a potent 14214 cholecystokinin-releasing peptide in the intestine (Correction)
Karl-Heinz Herzig, Ilona Sch6n, Kazuhiko Tatemoto, Yoshihide Ohe, Ying Li, Ulrich R. F6lsch, and Chung Owyang
MICROBIOLOGY
Activation of the JC virus Tat-responsive 14112-14117 transcriptional control element by association of the Tat protein of human immunodeficiency virus 1 with cellular protein Pura
Chavdar P. Krachmarov, Lara G. Chepenik, Sharon Barr-Vagell, Kamel Khalili, and Edward M. Johnson
Production of active bovine tracheal antimicrobial 14118-14121 peptide in milk of transgenic mice
S. Yarus, J. M. Rosen, A. M. Cole, and G. Diamond
Distinct roles for two G protein a subunits in fungal 14122-14127 virulence, morphology, and reproduction revealed by targeted gene disruption
Shaojian Gao and Donald L. Nuss
NEUROBIOLOGY
Potential brain neuronal targets for amphetamine-, 14128-14133 methylphenidate-, and modafinil-induced wakefulness, evidenced by c-fos immunocytochemistry in the cat
Jiang-Sheng Lin, Yiping Hou, and Michel Jouvet
Intrastriatally injected c-fos antisense oligonucleotide 14134-14139 interferes with striatonigral but not striatopallidal y-aminobutyric acid transmission in the conscious rat
W. Sommer, R. Rimondini, W. O'Connor, A. C. Hansson, U. Ungerstedt, and K. Fuxe
Transcriptional control of circadian hormone 14140-14145 synthesis via the CREM feedback loop
Nicholas S. Foulkes, Jimo Borjigin, Solomon H. Snyder, and Paolo Sassone-Corsi
Coexpression of Drosophila TRP and TRP-like 14146-14151 proteins in Xenopus oocytes reconstitutes capacitative Ca2+ entry
B. Gillo, I. Chorna, H. Cohen, B. Cook, I. Manistersky, M. Chorev, A. Arnon, J. A. Pollock, Z. Selinger, and B. Minke
Embryonic neuronal markers in tuberous sclerosis: 14152-14157 Single-cell molecular pathology
Peter B. Crino, John Q. Trojanowski, Marc A. Dichter, and James Eberwine
Microglia-passaged simian immunodeficiency virus 14158-14163 induces neurophysiological abnormalities in monkeys
Oscar Prosp6ro-Garcia, Lisa H. Gold, Howard S. Fox, Ilham Polis, George F. Koob, Floyd E. Bloom, and Steven J. Henriksen
Brain drug delivery of small 14164-14169 molecules using immunoliposomes
J6rg Huwyler, Dafang Wu, and William M. Pardridge
Interactions between two divalent ion binding sites 14170-14175 in N-methyl-D-aspartate receptor channels
Geeta Sharma and Charles F. Stevens
Transgenic mice carrying the dominant rhodopsin 14176-14181 mutation P347S: Evidence for defective vectorial transport of rhodopsin to the outer segments
Tiansen Li, Wendy K. Snyder, Jane E. Olsson, and Thaddeus P. Dryja
Levels of the growth-associated protein GAP-43 are 14182-14187 selectively increased in association cortices in schizophrenia
Nora I. Perrone-Bizzozero, Angela C. Sower, Edward D. Bird, Larry I. Benowitz, Kathryn J. Ivins, and Rachael L. Neve
PHARMACOLOGY
Identification and tissue-specific expression of 14188-14192 PDE7 phosphodiesterase splice variants
Timothy J. Bloom and Joseph A. Beavo
PHYSIOLOGY
Control of channel activity through a unique amino 14193-14198 acid residue of a G protein-gated inwardly rectifying K+ channel subunit
Kim W. Chan, Jin-Liang Sui, Michel Vivaudou, and Diomedes E. Logothetis
PLANT BIOLOGY
Arabidopsis thaliana defense-related protein ELI3 is 14199-14203 an aromatic alcohol:NADP+ oxidoreductase
Imre E. Somssich, Petra Wernert, Siegrid Kiedrowski, and Klaus Hahlbrock
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Contents
Identification of proton-active 14204-14209 residues in a higher plant light- harvesting complex
Robin G. Walters, Alexander V. Ruban, and Peter Horton
A conserved repetitive DNA element located in the 14210-14213 centromeres of cereal chromosomes
Jiming Jiang, Shuhei Nasuda, Fenggao Dong, Christopher W. Scherrer, Sung-Sick Woo, Rod A. Wing, Bikram S. Gill, and David C. Ward
AUTHOR INDEX xiii-xv
INFORMATION FOR CONTRIBUTORS xvi-xvii
COPYRIGHT ASSIGNMENT FORM xviii
CLASSIFIED ADVERTISEMENTS xix
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