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Front Matter Source: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, No. 24 (Nov. 26, 1996), pp. i-xii Published by: National Academy of Sciences Stable URL: http://www.jstor.org/stable/40918 . Accessed: 07/05/2014 15:48 Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at . http://www.jstor.org/page/info/about/policies/terms.jsp . JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact [email protected]. . National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access to Proceedings of the National Academy of Sciences of the United States of America. http://www.jstor.org This content downloaded from 169.229.32.136 on Wed, 7 May 2014 15:48:35 PM All use subject to JSTOR Terms and Conditions
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Page 1: Front Matter

Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 93, No. 24 (Nov. 26, 1996), pp. i-xiiPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/40918 .

Accessed: 07/05/2014 15:48

Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at .http://www.jstor.org/page/info/about/policies/terms.jsp

.JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range ofcontent in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new formsof scholarship. For more information about JSTOR, please contact [email protected].

.

National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access toProceedings of the National Academy of Sciences of the United States of America.

http://www.jstor.org

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Page 2: Front Matter

PROCEEDINGS

OF THE

NATIONAL ACADEMY OF SCIENCES

OF THE UNITED STATES OF AMERICA

November 26, 1996

Volume 93 / Number 24

INCLUDES: PAPERS FROM A NATIONAL ACADEMY OF SCIENCES COLLOQUIUM ON MEMORY: RECORDING EXPERIENCE IN CELLS AND CIRCUITS

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Page 3: Front Matter

1 2 3 4 5 67 8 9 10 0PharMingen now offers antibodies against the following apoptosis associated proteins:

Z ~~~~M onoclonal antibodies to human and mouse Fas and Fas Ligand now available!

*Bad Ich-I aCD3 10 GtiB Bak *Mci-I CDw7O

Flurecence ntnsty Bax *Nur77 aOX-40 * Bcl-2 * PARP * 4-I BB

0 Bcl-x 0 ~~RIP * ~~~~~~~~~For measuring apoptosis, we now offer the

APO-DIECT'-7 * kit, a system for single step detection of apoptotic cells by flow cytometry.

* ~~Visit us on the Web!

r4 -a ~http://www.pharmingen.com 107ToranRad4 To place an order call: Figure A: Figure A. DNA tragmentation induced by anti-mouse Fas mAb, (80 4M B 62) Sani Diego, CA 92121 Clone Jo2 (Cat # 15400D). A28 cells were incubated at 37 degrees C with For technical assistance call: [el: (619) 812-88100 Sng (4.~8).~ 25 ng (5.9) or SO ng/mi1 (6.10) ot anti-Fas tori1 hr (4-6) or 2 h rs (7- 10). Negative and isotype controls included A28 cells incubated without anti- (800) TALK-TEC (825-5832) v:ax: (619) 812-8888 PHAIIMINGI:N body (2) and with 50 ng/ml hamster lgG (3 [1 hr],7 [2 hr]). respectively ). DNA

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Page 4: Front Matter

PROCEEDINGS OF THE

NATIONAL ACADEMY OF SCIENCES

OF THE UNITED STATES OF AMERICA

Officers of the Academy

BRUCE ALBERTS, President JACK HALPERN, Vice President PETER H. RAVEN, Home Secretary F. SHERWOOD ROWLAND, Foreign Secretary RONALD L. GRAHAM, Treasurer

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Page 5: Front Matter

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Page 6: Front Matter

I / | I s U_1_ A

LEARNING ABOUT SOME OF

SCIENCE'S MOST AWE INSPIRIN6 ACHIEVEMENTS CAN BE

AN AMAZING EXPERIENCE. Now IMA6INE BEING PART OF THEm. AS A MEMBER OF ERNEST ORLANDo LAWRENCE

BERKELEY NATIONAL LABoRAToRY's LAWRENCE POSTDOCTORAL FELLOWSHIP PROGRAM, YOU WILL HAVE THE OPPORTUNITY TO ENHANCE

YOUR PROFESSIONAL DEVELOPMENT AS AN INTEGRAL MEMBER OF A LABORATORY RESEARCH TEAM IN YOUR FIELD OF EXPERTISE AND WORK WITH PROFESSIONALS FROM THE INTERNATIONAL COMMUNITY.

IF YOU'D LIKE TO ENTER A NEW ARENA OF INTELLECTUAL DISCOVERY, WALK THROUGH OUR DOORS. A' ~~~~~~~WE ARE CURRENTLY SEEKING CANDIDATES IN THE FOLLOWING BIOLOG~ICAL SCIENCES AREAS:

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BERKELEY LAB IS PROUD TO BE AN EQUAL OPPORTUNITY EMPLOYER DEDICATED TO THE DEVELOPMENT OF A DIVERSE WORKFORCE. WE PARTICU- LARLY INVITE AND ENCOURA6iE PROFESSIONALS OF ALL ETHNIC BACKGROUNDS TO CONSIDER MAKING INDIVIDUAL CONTRIBUTIONS TO OUR MULTI DI SCIPLINARY RESEARCH ENVIRONMENT.

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Page 7: Front Matter

NOTICE

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OF THE

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Page 8: Front Matter

PRO CEED INGS

OF THE

NATIONAL ACADEMY OF SCIENCES

OF THE UNITED STATES OF AMERICA

November 26, 1996 Volume 93, Number 24 pp. 13435-14214

Table of Contents

Papers from a National Academy of Sciences Colloquium on Memory: Recording Experience in Cells and Circuits

Memory: Recording experience in cells and circuits: 13435-13437 Diversity in memory research

Patricia S. Goldman-Rakic

Memory systems in the brain and localization of 13438-13444 a memory

Richard F. Thompson and Jeansok J. Kim

Toward a molecular definition of long-term 13445-13452 memory storage

Craig H. Bailey, Dusan Bartsch, and Eric R. Kandel

A synaptic basis for memory storage in the 13453-13459 cerebral cortex

Mark F. Bear

Discovery of genes involved with learning and 13460-13467 memory: An experimental synthesis of Hirschian and Benzerian perspectives

Tim Tully

The fractionation of working memory 13468-13472 Alan Baddeley

Regional and cellular fractionation of 13473-13480 working memory

Patricia S. Goldman-Rakic

Memory from the dynamics of intrinsic 13481-13486 membrane currents

Eve Marder, L. F. Abbott, Gina G. Turrigiano, Zheng Liu, and Jorge Golowasch

Ensemble codes involving hippocampal neurons are 13487-13493 at risk during delayed performance tests

Robert E. Hampson and Sam A. Deadwyler

Neural mechanisms for visual memory and their role 13494-13499 in attention

Robert Desimone

Functional organization of the hippocampal 13500-13507 memory system

Howard Eichenbaum, Geoffrey Schoenbaum, Brian Young, and Michael Bunsey

Involvement of the amygdala in memory storage: 13508-13514 Interaction with other brain systems

James L. McGaugh, Larry Cahill, and Benno Roozendaal

Structure and function of declarative and 13515-13522 nondeclarative memory systems

Larry R. Squire and Stuart M. Zola

v

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Page 9: Front Matter

Contents

Studies of retrograde memory: A long-term view 13523-13526 Elizabeth K. Warrington

Illusory memories: A cognitive neuroscience analysis 13527-13533 Daniel L. Schacter

Memory systems analyses of mnemonic disorders in 13534-13540 aging and age-related diseases

John D. E. Gabrieli

Muscarinic acetylcholine receptor expression in 13541-13546 memory circuits: Implications for treatment of Alzheimer disease

Allan I. Levey

Cognitive and neurobiologic markers of early 13547-13551 Alzheimer disease

Marilyn S. Albert

Commentary

Twinkle, twinkle little StAR, how we wonder what 13552-13554 you are

Ronald W. Estabrook and William E. Rainey

Inaugural Papers

YY1 transcriptional initiator: Protein interactions 13571-13576 and association with a DNA site containing unpaired strands

Anny Usheva and Thomas Shenk

The structural H19 gene is required for 13876-13883 transgene imprinting

Karl Pfeifer, Philip A. Leighton, and Shirley M. Tilghman

Physical Sciences

APPLIED PHYSICAL SCIENCES

Light-directed synthesis of high-density 13555-13560 oligonucleotide arrays using semiconductor photoresists

Glenn McGall, Jeff Labadie, Phil Brock, Greg Wallraff, Tien Nguyen, and William Hinsberg

Time-resolved optical diffusion tomographic image 13561-13564 reconstruction in highly scattering turbid media

W. Cai, B. B. Das, Feng Liu, M. Zevallos, M. Lax, and R. R. Alfano

Biological Sciences

APPLIED BIOLOGICAL SCIENCES

A helper-dependent adenovirus vector system: 13565-13570 Removal of helper virus by Cre-mediated excision of the viral packaging signal

Robin J. Parks, Liane Chen, Martina Anton, Uma Sankar, Michael A. Rudnicki, and Frank L. Graham

BIOCHEMISTRY

YY1 transcriptional initiator: Protein interactions 13571-13576 and association with a DNA site containing unpaired strands

Anny Usheva and Thomas Shenk

Cocrystal structure of YY1 bound to the 13577-13582 adeno-associated virus P5 initiator

Hristo B. Houbaviy, Anny Usheva, Thomas Shenk, and Stephen K. Burley

A small engineered protein lacks structural 13583-13588 uniqueness by increasing the side-chain conformational entropy

Koji Furukawa, Masayuki Oda, and Haruki Nakamura

Crystal structure of the secretory form of 13589-13594 membrane-associated human carbonic anhydrase IV at 2.8-A resolution

Travis Stams, Satish K. Nair, Torayuki Okuyama, Abdul Waheed, William S. Sly, and David W. Christianson

Evidence for a transcriptional activation function of 13595-13599 BRCA1 C-terminal region

Alvaro N. A. Monteiro, Avery August, and Hidesaburo Hanafusa

Sucrose biosynthesis in a prokaryotic organism: 13600-13604 Presence of two sucrose-phosphate synthases in Anabaena with remarkable differences compared with the plant enzymes

Andrea C. Porchia and Graciela L. Salerno

The role of apolipoprotein Al domains in 13605-13610 lipid binding

W. Sean Davidson, Theodore Hazlett, William W. Mantulin, and Ana Jonas

Molecular cloning and analysis of two subunits 13611-13616 of the human TFIID complex: hTAF11130 and hTAFII100

Naoko Tanese, Daman Saluja, Milo F. Vassallo, Jin-Long Chen, and Arie Admon

Chemical nature of the light emitter of the Aequorea 13617-13622 green fluorescent protein

Haruki Niwa, Satoshi Inouye, Takashi Hirano, Tatsuki Matsuno, Satoshi Kojima, Masayuki Kubota, Mamoru Ohashi, and Frederick I. Tsuji

PCR-based development of DNA substrates 13623-13628 containing modified bases: An efficient system for investigating the role of the exocyclic groups in chemical and structural recognition by minor groove binding drugs and proteins

Christian Bailly, Dominique Payet, Andrew A. Travers, and Michael J. Waring

hMSH2 forms specific mispair-binding complexes 13629-13634 with hMSH3 and hMSH6

Samir Acharya, Teresa Wilson, Scott Gradia, Michael F. Kane, Shawn Guerrette, Gerald T. Marsischky, Richard Kolodner, and Richard Fishel

vi

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Page 10: Front Matter

Contents

Superoxide accelerates DNA damage by elevating 13635-13640 free-iron levels

Kay Keyer and James A. Imlay

The essential yeast RNA binding protein 13641-13646 Npl3p is methylated

Christian W. Siebel and Christine Guthrie

Gly-63 -> Gln substitution adjacent to His-64 in 13647-13652 rodent carbonic anhydrase IVs largely explains their reduced activity

Shinya Tamai, Abdul Waheed, Lee B. Cody, and William S. Sly

Pepsin-inhibitory activity of the uterine serpins 13653-13658 Nagappan Mathialagan and Thomas R. Hansen

Zinc folds the N-terminal domain of HIV-1 13659-13664 integrase, promotes multimerization, and enhances catalytic activity

Ronglan Zheng, Timothy M. Jenkins, and Robert Craigie

Energy considerations show that low-barrier 13665-13670 hydrogen bonds do not offer a catalytic advantage over ordinary hydrogen bonds

Arieh Warshel and Arno Papazyan

A critical arginine residue mediates cooperativity in 13671-13676 the contact interface between transcription factors NFAT and AP-1

Blake R. Peterson, Li Jing Sun, and Gregory L. Verdine

Fidelity of RNA polymerase II transcription 13677-13682 controlled by elongation factor TFIIS

ChoonJu Jeon and Kan Agarwal

A peroxidase related to the mammalian antimicrobial 13683-13688 protein myeloperoxidase in the Euprymna- Vibrio mutualism

Virginia M. Weis, Andrea L. Srnall, and Margaret J. McFall-Ngai

Elimination of the Chlamydomonas gene family that 13689-13693 encodes the small subunit of ribulose-1,5- bisphosphate carboxylase/oxygenase

Irina Khrebtukova and Robert J. Spreitzer

A Drosophila gene structurally and functionally 13694-13698 homologous to the mammalian 70-kDa S6 kinase gene

Kellie L. Watson, Margaret M. Chou, John Blenis, William M. Gelbart, and Raymond L. Erikson

The reaction of fluorocitrate with aconitase 13699-13703 and the crystal structure of the enzyme- inhibitor complex

H. Lauble, M. C. Kennedy, M. H. Emptage, H. Beinert, and C. D. Stout

In vitro activation of Stat3 by epidermal growth 13704-13708 factor receptor kinase

Ohkmae K. Park, Timothy S. Schaefer, and Daniel Nathans

Recurrent G-to-A substitution in a single codon of 13709-13714 SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines

Axel Nohturfft, Xianxin Hua, Michael S. Brown, and Joseph L. Goldstein

Melanotropic peptide-conjugated beads for 13715-13720 microscopic visualization and characterization of melanoma melanotropin receptors

Shubh D. Sharma, Jinwen Jiang, Mac E. Hadley, David L. Bentley, and Victor J. Hruby

A cytokine mRNA-destabilizing element that is 13721-13725 structurally and functionally distinct from A+U-rich elements

Cheryl Y. Brown, Cathy A. Lagnado, and Gregory J. Goodall

Defective subunit assembly underlies a digenic form 13726-13730 of retinitis pigmentosa linked to mutations in peripherin/rds and rom-1

Andrew F. X. Goldberg and Robert S. Molday

Steroidogenic acute regulatory protein (StAR) retains 13731-13736 activity in the absence of its mitochondrial import sequence: Implications for the mechanism of StAR action

Futoshi Arakane, Teruo Sugawara, Hideaki Nishino, Zhiming Liu, John A. Holt, Debkumar Pain, Douglas M. Stocco, Walter L. Miller, and Jerome F. Strauss, III

An unusual mechanism for the major human 13737-13741 apurinic/apyrimidinic (AP) endonuclease involving 5' cleavage of DNA containing a benzene-derived exocyclic adduct in the absence of an AP site

B. Hang, A. Chenna, H. Fraenkel-Conrat, and B. Singer

Involvement of the cyclin-dependent kinase inhibitor 13742-13747 p16 (INK4a) in replicative senescence of normal human fibroblasts

David A. Alcorta, Yue Xiong, Dawn Phelps, Greg Hannon, David Beach, and J. Carl Barrett

Molecular characterization of the human peroxisomal 13748-13753 branched-chain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger syndrome

Eveline Baumgart, Johannes C. T. Vanhooren, Mark Fransen, Peter Marynen, Magda Puype, Joel Vandekerckhove, Jack A. M. Leunissen, H. Dariush Fahimi, Guy P. Mannaerts, and Paul P. Van Veldhoven

Metal binding properties and secondary structure of 13754-13759 the zinc-binding domain of Nup475

Mark T. Worthington, Barbara T. Amann, Daniel Nathans, and Jeremy M. Berg

The Saccharomyces CDC13 protein is a single-strand 13760-13765 TG1_3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo

Jing-Jer Lin and Virginia A. Zakian

vii

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Page 11: Front Matter

Contents

Fork-like DNA templates support bypass replication 13766-13769 of lesions that block DNA synthesis on single-stranded templates

Jean-Sebastien Hoffmann, Marie-Jeanne Pillaire, Claire Lesca, Dominique Burnouf, Robert P. P. Fuchs, Martine Defais, and Giuseppe Villani

BIOPHYSICS

Characterization of individual polynucleotide 13770-13773 molecules using a membrane channel

John J. Kasianowicz, Eric Brandin, Daniel Branton, and David W. Deamer

Ultrafast exciton relaxation in the B850 antenna 13774-13779 complex of Rhodobacter sphaeroides

V. Nagarajan, R. G. Alden, J. C. Williams, and W. W. Parson

CELL BIOLOGY

TOR2 is required for organization of the actin 13780-13785 cytoskeleton in yeast

Anja Schmidt, Jeannette Kunz, and Michael N. Hall

Inhibition of interleukin 1/3-converting 13786-13790 enzyme-mediated apoptosis of mammalian cells by baculovirus IAP

Christine J. Hawkins, Anthony G. Uren, Georg Hacker, Robert L. Medcalf, and David L. Vaux

Interferon-inducible protein-10 identified as a 13791-13796 mediator of tumor necrosis in vivo

Cecilia Sgadari, Anne L. Angiolillo, Barry W. Cherney, Sandra E. Pike, Joshua M. Farber, Leonidas G. Koniaris, Padmavathy Vanguri, Parris R. Burd, Nasreen Sheikh, Ghanshyam Gupta, Julie Teruya-Feldstein, and Giovanna Tosato

Proteasome-dependent endoplasmic 13797-13801 reticulum-associated protein degradation: An unconventional route to a familiar fate

Eric D. Werner, Jeffrey L. Brodsky, and Ardythe A. McCracken

The highly conserved skbl gene encodes a protein 13802-13807 that interacts with Shkl, a fission yeast Ste20/PAK homolog

Mary Gilbreth, Peirong Yang, Dan Wang, Jeff Frost, Anthony Polverino, Melanie H. Cobb, and Stevan Marcus

Calexcitin: A signaling protein that binds 13808-13813 calcium and GTP, inhibits potassium channels, and enhances membrane excitability

Thomas J. Nelson, Sebastiano Cavallaro, Chu-Li Yi, Donna McPhie, Bernard G. Schreurs, Pavel A. Gusev, Antonella Favit, Ofer Zohar, Jeongho Kim, Sven Beushausen, Giorgio Ascoli, James Olds, Rachael Neve, and Daniel L. Alkon

Involvement of stress-activated protein kinase and 13814-13818 p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes

J. D. Graves, K. E. Draves, A. Craxton, J. Saklatvala, E. G. Krebs, and E. A. Clark

Multiple A-type cyclins express sequentially 13819-13824 during the cell cycle in Nicotiana tabacum BY2 cells

Jean-Philippe Reichheld, Nicole Chaubet, Wen Hui Shen, Jean-Pierre Renaudin, and Claude Gigot

The DNA damage response in DNA-dependent 13825-13830 protein kinase-deficient SCID mouse cells: Replication protein A hyperphosphorylation and p53 induction

Laura M. Fried, Constantinos Koumenis, Scott R. Peterson, Susannah L. Green, Pierre van Zijl, Joan Allalunis-Turner, David J. Chen, Richard Fishel, Amato J. Giaccia, J. Martin Brown, and Cordula U. Kirchgessner

DEVELOPMENTAL BIOLOGY

Flowers into shoots: Photo and hormonal control 13831-13836 of a meristem identity switch in Arabidopsis

Jack K. Okamuro, Bart G. W. den Boer, Cynthia Lotys-Prass, Wayne Szeto, and K. Diane Jofuku

Multiple potential germ-line helicases are components 13837-13842 of the germ-line-specific P granules of Caenorhabditis elegans

M. E. Gruidl, P. A. Smith, K. A. Kuznicki, J. S. McCrone, J. Kirchner, D. L. Roussell, S. Strome, and K. L. Bennett

Blockade of plasma membrane calcium pumping 13843-13848 ATPase isoform I impairs nerve growth factor-induced neurite extension in pheochromocytoma cells

Paul C. Brandt, Jesse E. Sisken, Rachael L. Neve, and Thomas C. Vanaman

Developmental expression of synthetic cis-regulatory 13849-13854 systems composed of spatial control elements from two different genes

Carmen V. Kirchhamer, Leonard D. Bogarad, and Eric H. Davidson

ECOLOGY

Effects of productivity, consumers, competitors, and 13855-13858 El Niho events on food chain patterns in a rocky intertidal community

J. T. Wootton, M. E. Power, R. T. Paine, and C. A. Pfister

EVOLUTION

Misconceptions about mitochondria and mammalian 13859-13863 fertilization: Implications for theories on human evolution

Friderun AnkebSimons and Jim M. CLtmmins

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GENETICS

Dimerization of Ste5, a mitogen-activated protein 13864-13869 kinase cascade scaffold protein, is required for signal transduction

Deborah Yablonski, Irit Marbach, and Alexander Levitzki

The mouse Pax2lNeu mutation is identical to a 13870-13875 human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney

Jack Favor, Rodica Sandulache, Angelika Neuhauser-Klaus, Walter Pretsch, Bimal Chatterjee, Elfriede Senft, Wolfgang Wurst, Veronique Blanquet, Patricia Grimes, Ralf Sp6rle, and Klaus Schughart

The structural H19 gene is required for 13876-13883 transgene imprinting

Karl Pfeifer, Philip A. Leighton, and Shirley M. Tilghman

Intron of the mouse Hoxa-7 gene contains conserved 13884-13889 homeodomain binding sites that can function as an enhancer element in Drosophila

Theodor E. Haerry and Walter J. Gehring

A human homolog of the Schizosaccharomyces pombe 13890-13895 rad9+ checkpoint control gene

Howard B. Lieberman, Kevin M. Hopkins, Monica Nass, Douglas Demetrick, and Scott Davey

A positive genetic selection for disrupting 13896-13901 protein-protein interactions: Identification of CREB mutations that prevent association with the coactivator CBP

Hsiu-ming Shih, Phyllis S. Goldman, Anthony J. DeMaggio, Stanley M. Hollenberg, Richard H. Goodman, and Merl F. Hoekstra

Cell cycle-regulated generation of single-stranded 13902-13907 G-rich DNA in the absence of telomerase

Isabelle Dionne and Raymund J. Wellinger

A procedure for the prediction of 13908-13913 temperature-sensitive mutants of a globular protein based solely on the amino acid sequence

R. Varadarajan, H. A. Nagarajaram, and C. Ramakrishnan

An upstream activator of transcription coordinately 13914-13918 increases the level and epigenetic stability of gene expression

Wendy Magis, Steven Fiering, Mark Groudine, and David I. K. Martin

Transcription-induced mutations: Increase in C to T 13919-13924 mutations in the nontranscribed strand during transcription in Escherichia coli

A. Beletskii and Ashok S. Bhagwat

Highly selective isolation of human DNAs from 13925-13930 rodent-human hybrid cells as circular yeast artificial chromosomes by transformation-associated recombination cloning

Vladimir Larionov, Natalya Kouprina, Joan Graves, and Michael A. Resnick

Promiscuous translocations into immunoglobulin 13931-13936 heavy chain switch regions in multiple myeloma

P. Leif Bergsagel, Marta Chesi, Elena Nardini, Leslie A. Brents, Suzanne L. Kirby, and W. Michael Kuehl

Two eukaryote-specific regions of Hsp82 are 13937-13942 dispensable for its viability and signal transduction functions in yeast

Jean-Frangois Louvion, Rainer Warth, and Didier Picard

NRF2, a member of the NFE2 family of transcription 13943-13948 factors, is not essential for murine erythropoiesis, growth, and development

Kaimin Chan, Ronghua Lu, Judy C. Chang, and Yuet Wai Kan

Lack of chromosome territoriality in yeast: 13949-13954 Promiscuous rejoining of broken chromosome ends

James E. Haber and Wai-Ying Leung

myb provides an essential function during 13955-13960 Drosophila development

Alisa L. Katzen and J. Michael Bishop

Absence of the /3 subunit (cchbl) of the skeletal 13961-13966 muscle dihydropyridine receptor alters expression of the a, subunit and eliminates excitation- contraction coupling

Ronald G. Gregg, Albee Messing, Caroline Strube, Maryline Beurg, Richard Moss, Mary Behan, Manana Sukhareva, Susan Haynes, Jeanne A. Powell, Roberto Coronado, and Patricia A. Powers

IMMUNOLOGY

Costimulatory function and expression of CD40 13967-13972 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection

Wayne W. Hancock, Mohamed H. Sayegh, Xiang-Guang Zheng, Robert Peach, Peter S. Linsley, and Laurence A. Turka

The tumor necrosis factor receptor 2 signal 13973-13978 transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

Hong-Bing Shu, Masahiro Takeuchi, and David V. Goeddel

Modifying the sequence of an immunoglobulin 13979-13984 V-gene alters the resulting pattern of hypermutation

Beatriz Goyenechea and Cesar Milstein

Role of p300-family proteins in EIA oncogene 13985-13990 induction of cytolytic susceptibility and tumor cell rejection

James L. Cook, Carol K. Krantz, and Barbara A. Routes

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The mouse mammary tumor virus env gene is the 13991-13996 source of a CD8+ T-cell-stimulating peptide presented by a major histocompatibility complex class I molecule in a murine thymoma

Subramaniam Malarkannan, Thomas Serwold, Vu Nguyen, Linda A. Sherman, and Nilabh Shastri

Deglucosylation of N-linked glycans is an important 13997-14001 step in the dissociation of calreticulin-class I-TAP complexes

Jeroen E. M. Van Leeuwen and Kelly P. Kearse

A functional interleukin 12 receptor complex is 14002-14007 composed of two /3-type cytokine receptor subunits

David H. Presky, Hong Yang, Lisa J. Minetti, Anne 0. Chua, Nasrin Nabavi, Chang-You Wu, Maurice K. Gately, and Ueli Gubler

In vitro V(D)J recombination: Signal joint formation 14008-14013 Patricia Cortes, Frances Weis-Garcia, Ziva Misulovin, Andre Nussenzweig, Jiann-Shiun Lai, Gloria Li, Michel C. Nussenzweig, and David Baltimore

MEDICAL SCIENCES

A novel mechanism of action of tetracyclines: Effects 14014-14019 on nitric oxide synthases

Ashok R. Amin, Mukundan G. Attur, Geeta D. Thakker, Prakash D. Patel, Pranav R. Vyas, Rajesh N. Patel, Indravadan R. Patel, and Steven B. Abramson

In situ hybridization analysis of presenilin 14020-14024 1 mRNA in Alzheimer disease and in lesioned rat brain

Keith Page, Richard Hollister, Rudolph E. Tanzi, and Bradley T. Hyman

Frequent clones of p53-mutated keratinocytes in 14025-14029 normal human skin

Alan S. Jonason, Subrahmanyam Kunala, Gary J. Price, Richard J. Restifo, Henry M. Spinelli, John A. Persing, David J. Leffell, Robert E. Tarone, and Douglas E. Brash

Biochemical characterization and intracellular 14030-14035 localization of the Menkes disease protein

Yukitoshi Yamaguchi, Mark E. Heiny, Mariko Suzuki, and Jonathan D. Gitlin

Ribonucleotide reductase R2 component is a novel 14036-14040 malignancy determinant that cooperates with activated oncogenes to determine transformation and malignant potential

Huizhou Fan, Cristy Villegas, and Jim A. Wright

Disruption of the acyl-CoA:cholesterol acyltransferase 14041-14046 gene in mice: Evidence suggesting multiple cholesterol esterification enzymes in mammals

Vardiella L. Meiner, Sylvaine Cases, Heather M. Myers, Eric R. Sande, Stefano Bellost a, Morris Schamb elan, Robert E. Pitas, James McGuire, Joachim Herz, and Robert V. Farese, Jr.

Tumor progression to the metastatic state involves 14047-14052 structural modifications in DNA markedly different from those associated with primary tumor formation

Donald C. Malins, Nayak L. Polissar, and Sandra J. Gunselman

Tumor necrosis factor receptor-associated factor 14053-14058 (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation

Stephane Ansieau, Inka Scheffrahn, George Mosialos, Heike Brand, Justus Duyster, Kenneth Kaye, Josephine Harada, Bill Dougall, Gabi Hubinger, Elliott Kieff, Friedhelm Herrmann, Achim Leutz, and Hans-Jurgen Gruss

The AMLI/ETO fusion protein activates 14059-14064 transcription of BCL-2

Lidija Klampfer, Jin Zhang, Andrew 0. Zelenetz, Hideo Uchida, and Stephen D. Nimer

Brain monoamine oxidase A inhibition in 14065-14069 cigarette smokers

Joanna S. Fowler, Nora D. Volkow, Gene-Jack Wang, Naomi Pappas, Jean Logan, Colleen Shea, David Alexoff, Robert R. MacGregor, David J. Schlyer, Ivana Zezulkova, and Alfred P. Wolf

Efficient gene transfer by a human immunodeficiency 14070-14075 virus type 1 (HIV-1)-derived vector utilizing a stable HIV packaging cell line

Pierre Corbeau, Gunter Kraus, and Flossie Wong-Staal

HIV replication in CD4+ T cells of HIV-infected 14076-14081 individuals is regulated by a balance between the viral suppressive effects of endogenous /3-chemokines and the viral inductive effects of other endogenous cytokines

Audrey L. Kinter, Mario Ostrowski, Delia Goletti, Alessandra Oliva, Drew Weissman, Kira Gantt, Elena Hardy, Robert Jackson, Linda Ehler, and Anthony S. Fauci

Gene delivery to skeletal muscle results in sustained 14082-14087 expression and systemic delivery of a therapeutic protein

Paul D. Kessler, Gregory M. Podsakoff, Xiaojuan Chen, Susan A. McQuiston, Peter C. Colosi, Laura A. Matelis, Gary J. Kurtzman, and Barry J. Byrne

Retroviral transduction of a mutant methylguanine 14088-14093 DNA methyltransferase gene into human CD34 cells confers resistance to 06-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea

Jane S. Reese, Omer N. KoW, Keun Myoung Lee, Lili Liu, James A. Allay, Weldon P. Phillips, Jr., and Stanton L. Gerson

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BAX enhances paclitaxel-induced apoptosis through 14094-14099 a p53-independent pathway

Thomas Strobel, Linda Swanson, Stanley Korsmeyer, and Stephen A. Cannistra

Older males secrete luteinizing hormone and 14100-14105 testosterone more irregularly, and jointly more asynchronously, than younger males

Steven M. Pincus, Thomas Mulligan, Ali Iranmanesh, Sylvia Gheorghiu, Michael Godschalk, and Johannes D. Veldhuis

The tumorigenic potential and cell growth 14106-14111 characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2

Stephen N. Jones, Arthur T. Sands, Amy R. Hancock, Hannes Vogel, Lawrence A. Donehower, Steven P. Linke, Geoffrey M. Wahl, and Allan Bradley

Diazepam binding inhibitor is a potent 14214 cholecystokinin-releasing peptide in the intestine (Correction)

Karl-Heinz Herzig, Ilona Sch6n, Kazuhiko Tatemoto, Yoshihide Ohe, Ying Li, Ulrich R. F6lsch, and Chung Owyang

MICROBIOLOGY

Activation of the JC virus Tat-responsive 14112-14117 transcriptional control element by association of the Tat protein of human immunodeficiency virus 1 with cellular protein Pura

Chavdar P. Krachmarov, Lara G. Chepenik, Sharon Barr-Vagell, Kamel Khalili, and Edward M. Johnson

Production of active bovine tracheal antimicrobial 14118-14121 peptide in milk of transgenic mice

S. Yarus, J. M. Rosen, A. M. Cole, and G. Diamond

Distinct roles for two G protein a subunits in fungal 14122-14127 virulence, morphology, and reproduction revealed by targeted gene disruption

Shaojian Gao and Donald L. Nuss

NEUROBIOLOGY

Potential brain neuronal targets for amphetamine-, 14128-14133 methylphenidate-, and modafinil-induced wakefulness, evidenced by c-fos immunocytochemistry in the cat

Jiang-Sheng Lin, Yiping Hou, and Michel Jouvet

Intrastriatally injected c-fos antisense oligonucleotide 14134-14139 interferes with striatonigral but not striatopallidal y-aminobutyric acid transmission in the conscious rat

W. Sommer, R. Rimondini, W. O'Connor, A. C. Hansson, U. Ungerstedt, and K. Fuxe

Transcriptional control of circadian hormone 14140-14145 synthesis via the CREM feedback loop

Nicholas S. Foulkes, Jimo Borjigin, Solomon H. Snyder, and Paolo Sassone-Corsi

Coexpression of Drosophila TRP and TRP-like 14146-14151 proteins in Xenopus oocytes reconstitutes capacitative Ca2+ entry

B. Gillo, I. Chorna, H. Cohen, B. Cook, I. Manistersky, M. Chorev, A. Arnon, J. A. Pollock, Z. Selinger, and B. Minke

Embryonic neuronal markers in tuberous sclerosis: 14152-14157 Single-cell molecular pathology

Peter B. Crino, John Q. Trojanowski, Marc A. Dichter, and James Eberwine

Microglia-passaged simian immunodeficiency virus 14158-14163 induces neurophysiological abnormalities in monkeys

Oscar Prosp6ro-Garcia, Lisa H. Gold, Howard S. Fox, Ilham Polis, George F. Koob, Floyd E. Bloom, and Steven J. Henriksen

Brain drug delivery of small 14164-14169 molecules using immunoliposomes

J6rg Huwyler, Dafang Wu, and William M. Pardridge

Interactions between two divalent ion binding sites 14170-14175 in N-methyl-D-aspartate receptor channels

Geeta Sharma and Charles F. Stevens

Transgenic mice carrying the dominant rhodopsin 14176-14181 mutation P347S: Evidence for defective vectorial transport of rhodopsin to the outer segments

Tiansen Li, Wendy K. Snyder, Jane E. Olsson, and Thaddeus P. Dryja

Levels of the growth-associated protein GAP-43 are 14182-14187 selectively increased in association cortices in schizophrenia

Nora I. Perrone-Bizzozero, Angela C. Sower, Edward D. Bird, Larry I. Benowitz, Kathryn J. Ivins, and Rachael L. Neve

PHARMACOLOGY

Identification and tissue-specific expression of 14188-14192 PDE7 phosphodiesterase splice variants

Timothy J. Bloom and Joseph A. Beavo

PHYSIOLOGY

Control of channel activity through a unique amino 14193-14198 acid residue of a G protein-gated inwardly rectifying K+ channel subunit

Kim W. Chan, Jin-Liang Sui, Michel Vivaudou, and Diomedes E. Logothetis

PLANT BIOLOGY

Arabidopsis thaliana defense-related protein ELI3 is 14199-14203 an aromatic alcohol:NADP+ oxidoreductase

Imre E. Somssich, Petra Wernert, Siegrid Kiedrowski, and Klaus Hahlbrock

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Identification of proton-active 14204-14209 residues in a higher plant light- harvesting complex

Robin G. Walters, Alexander V. Ruban, and Peter Horton

A conserved repetitive DNA element located in the 14210-14213 centromeres of cereal chromosomes

Jiming Jiang, Shuhei Nasuda, Fenggao Dong, Christopher W. Scherrer, Sung-Sick Woo, Rod A. Wing, Bikram S. Gill, and David C. Ward

AUTHOR INDEX xiii-xv

INFORMATION FOR CONTRIBUTORS xvi-xvii

COPYRIGHT ASSIGNMENT FORM xviii

CLASSIFIED ADVERTISEMENTS xix

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