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Front Matter Source: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, No. 13 (Jun. 24, 1997), pp. i-vii Published by: National Academy of Sciences Stable URL: http://www.jstor.org/stable/42193 . Accessed: 07/05/2014 20:11 Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at . http://www.jstor.org/page/info/about/policies/terms.jsp . JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact [email protected]. . National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access to Proceedings of the National Academy of Sciences of the United States of America. http://www.jstor.org This content downloaded from 169.229.32.136 on Wed, 7 May 2014 20:11:49 PM All use subject to JSTOR Terms and Conditions
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Page 1: Front Matter

Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 94, No. 13 (Jun. 24, 1997), pp. i-viiPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/42193 .

Accessed: 07/05/2014 20:11

Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at .http://www.jstor.org/page/info/about/policies/terms.jsp

.JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range ofcontent in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new formsof scholarship. For more information about JSTOR, please contact [email protected].

.

National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access toProceedings of the National Academy of Sciences of the United States of America.

http://www.jstor.org

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Page 2: Front Matter

PROCEEDINGS OF THE

NATIONAL ACADEMY OF SCIENCES

OF THE UNITED STATES OF AMERICA

June 24, 1997 Volume 94 / Number 13

INCLUDES: FROM THE ACADEMY FEATURING FRONTIERS OF SCIENCE

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Page 3: Front Matter

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Page 4: Front Matter

PROCEEDINGS OF THE

NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Officers of the Academy

BRUCE ALBERTS, President JACK HALPERN, Vice President PETER H. RAVEN, Home Secretary F. SHERWOOD ROWLAND, Foreign Secretary RONALD L. GRAHAM, Treasurer

Editor-in-Chief NICHOLAS R. COZZARELLI

Editorial Board of the Proceedings

PETER J. BICKEL WILLIAM CATTERALL ANTHONY CERAMI PIERRE CHAMBON MICHAEL T. CLEGG MARSHALL H. COHEN STANLEY N. COHEN DAVID R. DAVIES HERMAN N. EISEN RAYMOND L. ERIKSON ANTHONY S. FAUCI

NINA FEDOROFF CHARLES FEFFERMAN JOSEPH L. GOLDSTEIN CAROL A. GROSS JACK HALPERN PIERRE C. HOHENBERG BERTIL HILLE H. ROBERT HORVITZ ROGER KORNBERG HARVEY F. LODISH PHIL W. MAJERUS

PHILIPPA MARRACK ARNO G. MOTULSKY RONALD L. PHILLIPS TOM POLLARD STANLEY B. PRUSINER CHARLES RADDING GIAN-CARLO ROTA PAUL R. SCHIMMEL STUART L. SCHREIBER AARON J. SHATKIN CARLA J. SHATZ

CHRISTOPHER A. SIMS ALLAN C. SPRADLING LARRY R. SQUIRE CHARLES F. STEVENS JOANNE STUBBE KARL K. TUREKIAN DON C. WILEY PETER G. WOLYNES

Publisher: KENNETH R. FULTON Managing Editor: DIANE M. SULLENBERGER Business Manager: MARIA L. LEBR6N Associate Editorial Manager: JOHN M. MALLOY Associate Manager for Production: JOANNE D'AMIco Production Coordinator: BARBARA A. BACON Editorial Coordinator: THOR RUNEMAN System Administrator: MARILYN J. MASON Manuscript Coordinator: JACQUELINE V. PERRY Administrative/Systems Assistant: DOTTIE A. MAY Administrative Assistant: DANIEL H. SALSBURY Financial Assistant: JULIA A. LITTLE Subscription Fulfillment Assistant: CYNTHIA MATHEWS Secretary: BRENDA L. MCCOY

Correspondence: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, NW, Washington, DC 20418 USA (via U.S. postal service) or Foundry Building, 1055 Thomas Jefferson Street, NW, Room 2013, Washington, DC 20007 USA (via courier service). Information for Authors: See pp. xii and xiii (of this issue). See also http://www.pnas.org. Copyright: Volumes 90-94, copyright ? 1993-1997 by the National Academy of Sciences; Volumes 1-89, copyright as a collective work only with copyright to individual articles retained by the author(s). Requests for permission to reproduce all or parts of individual articles published in Volumes 1-89 should be addressed to the authors. The journal is registered with the Copyright Clearance Center, 222 Rosewood Drive, Danvers, MA 01923, FAX 508-750-4744. Microforms of complete volumes are available and may be obtained from University Microfilms, Xerox Corporation, Ann Arbor, MI 48103. This journal is printed on acid-free paper effective with Volume 84, Issue 1. Subscriptions: All subscription correspondence should be addressed to the Circulation Office of the PROCEEDINGS, 2101 Constitution Avenue, NW, Washington, DC 20418 USA. Subscriptions are entered on a calendar-year basis only. For 1997, subscription rates are as follows-in the United States: Student, $90; Postdoctoral, $125; Personal, $150; Institutional, $615; elsewhere by surface mail: Student, $190; Postdoctoral, $225; Personal, $250; Institutional, $715; elsewhere by expedited air delivery at a surcharge of $234. Other air mail postage rates are available on request. Subscribers in Japan must submit orders to our exclusive agent, USACO Corporation, 13-12, Shimbashi, 1-Chome, Minato-ku, Tokyo 105 Japan. Subscribers are requested to notify the Circulation Office 6 weeks in advance of any change of address. The Academy is not responsible for nonreceipt of issues because of an improper address unless a change of address is on file. The notice of address change should list both the old and new addresses. Claims for replacement copies will not be honored more than 60 days after the issue date for domestic subscribers and not more than 90 days after the issue date for foreign subscribers. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES is also available online at http://www.pnas.org. Single Copies: Cost per issue: USA, $30; Elsewhere, $40. Canadian GST Registration Number R-133130880. Periodicals class postage paid at Washington, DC, anld at additional mailing offices. PRINTED IN THE USA PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (ISSN-0027-8424) is published biweekly by THE NATIONAL ACADEMY OF SCIENCES.

? 1997 by THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.

POSTMASTER: Send address changes to: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2101 Constitution Avenue, NW, Washington, DC 20418 USA. Cover photograph: Over the East Gallery is the crowned lynx, symbol of the Accademia dei Lincei, Rome, founded in 1603.

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Page 5: Front Matter

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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Make remittance payable to the National Academy of Sciences. Foreign remittance must be by draft on a U.S. Bank or by International Money Order. Student and Postdoctoral subscriptions must be paid by personal check, money order, or credit card.

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Page 6: Front Matter

PROCEEDINGS OF THE

NATIONAL ACADEMY OF S CIENCE

OF THE UNITED STATES OF AMERICA

June 24, 1997 Volume 94, Number 13 pp. 6579-7120

Table of Contents

From the Academy

The age of the universe 6579-6584 David N. Spergel, Michael Bolte, and Wendy Freedman

Mathematical approaches to comparative linguistics 6585-6590 Tandy Warnow

Physical Sciences

CHEMISTRY

Nonenzymatic and enzymatic hydrolysis of alkyl 6591-6595 halides: A theoretical study of the SN2 reactions of acetate and hydroxide ions with alkyl chlorides

Andreas H. Maulitz, Felice C. Lightstone, Ya-Jun Zheng, and Thomas C. Bruice

ENGINEERING

Reported emissions of organic gases are not 6596-6599 consistent with observations

Ronald C. Henry, Clifford H. Spiegelman, John F. Collins, and EunSug Park

GEOLOGY

Isotopes, ice ages, and terminal Proterozoic 6600-6605 earth history

Alan J. Kaufman, Andrew H. Knoll, and Guy M. Narbonne

STATISTICS

Sample size determination in combinatorial chemistry 7120 (Correction)

Peng-Liang Zhao, Robert Zambias, James A. Bolognese, David Boulton, and Kevin Chapman

Biological Sciences

APPLIED BIOLOGICAL SCIENCES

Peptidyl-transferase inhibitors have antiviral 6606-6611 properties by altering programmed -1 ribosomal frameshifting efficiencies: Development of model systems

Jonathan D. Dinman, Maria J. Ruiz-Echevarria, Kevin Czaplinski, and Stuart W. Peltz

The heat shock-induced hyperphosphorylation of T is 6612-6617 estrogen-independent and prevented by androgens: Implications for Alzheimer disease

Sozos Ch. Papasozomenos

BIOCHEMISTRY

Prion-inducing domain 2-114 of yeast Sup35 protein 6618-6622 transforms in vitro into amyloid-like filaments

Chih-Yen King, Peter Tittmann, Heinz Gross, Roland Gebert, Markus Aebi, and Kurt Wiithrich

iii

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Page 7: Front Matter

Contents An extended DNA structure through deoxyribose-base 6623-6628 stacking induced by RecA protein

Taro Nishinaka, Yutaka Ito, Shigeyuki Yokoyama, and Takehiko Shibata

Covalent modification of the active site threonine of 6629-6634 proteasomal 13 subunits and the Escherichia coli homolog HslV by a new class of inhibitors

Matthew Bogyo, John S. McMaster, Maria Gaczynska, Domenico Tortorella, Alfred L. Goldberg, and Hidde Ploegh

The rational design and construction of a cuboidal 6635-6640 iron-sulfur protein

Christopher D. Coldren, Homme W. Hellinga, and John P. Caradonna

Modular organization of the catalytic center of 6641-6645 RNA polymerase

Arkady Mustaev, Maxim Kozlov, Vadim Markovtsov, Evgeny Zaychikov, Ludmila Denissova, and Alex Goldfarb

Defective prohormone processing and altered 6646-6651 pancreatic islet morphology in mice lacking active SPC2

Machi Furuta, Hideki Yano, An Zhou, Yves Rouille, Jens J. Holst, Raymond Carroll, Mariella Ravazzola, Lelio Orci, Hiroto Furuta, and Donald F. Steiner

Crystal structure of the homo-tetrameric DNA 6652-6657 binding domain of Escherichia coli single-stranded DNA-binding protein determined by multiwavelength x-ray diffraction on the selenomethionyl protein at 2.9-A resolution

Srinivasan Raghunathan, Cynthia S. Ricard, Timothy M. Lohman, and Gabriel Waksman

c-Myc transactivation of LDH-A: Implications for 6658-6663 tumor metabolism and growth

Hyunsuk Shim, Christine Dolde, Brian C. Lewis, Chyi-Sun Wu, Gerard Dang, Richard A. Jungmann, Riccardo Dalla-Favera, and Chi V. Dang

Bipartite substrate discrimination by human 6664-6669 nucleotide excision repair

Martin T. Hess, Urs Schwitter, Mario Petretta, Bernd Giese, and Hanspeter Naegeli

Binding of human virus oncoproteins to hDlg/SAP97, 6670-6675 a mammalian homolog of the Drosophila discs large tumor suppressor protein

Siu Sylvia Lee, Robert S. Weiss, and Ronald T. Javier

In vitro and in vivo characterization of novel mRNA 6676-6681 motifs that bind special elongation factor SelB

Stefanie J. Klug, Alexander Hiittenhofer, Matthias Kromayer, and Michael Famulok

Pacifastin, a novel 155-kDa heterodimeric proteinase 6682-6687 inhibitor containing a unique transferrin chain

Zicai Liang, Lars Sottrup-Jensen, Anna Aspan, Martin Hall, and Kenneth Soderhaill

DNA damage-dependent transcriptional arrest and 6688-6693 termination of RNA polymerase II elongation complexes in DNA template containing HIV-1 promoter

Zhuying Wang and Tariq M. Rana

Monomeric isomers of human interleukin 5 show that 6694-6699 1:1 receptor recruitment is sufficient for function

Jun Li, Richard Cook, Michael L. Doyle, Preston Hensley, Dean E. McNulty, and Irwin Chaiken

Mutations in HIV reverse transcriptase which alter 6700-6705 RNase H activity and decrease strand transfer efficiency are suppressed by HIV nucleocapsid protein

Craig E. Cameron, Madhumita Ghosh, Stuart F. J. Le Grice, and Stephen J. Benkovic

The recombination hotspot Chi is recognized by the 6706-6711 translocating RecBCD enzyme as the single strand of DNA containing the sequence 5'-GCTGGTGG-3'

Piero R. Bianco and Stephen C. Kowalczykowski

Alterations of the outer membrane composition in 6712-6717 Escherichia coli lacking the histone-like protein HU

Eric Painbeni, Martine Caroff, and Josette Rouviere-Yaniv

Activation of RNA polymerase II by topologically 6718-6723 linked DNA-tracking proteins

Mohamed Ouhammouch, Michael H. Sayre, James T. Kadonaga, and E. Peter Geiduschek

The abalone egg vitelline envelope receptor for sperm 6724-6729 lysin is a giant multivalent molecule

Willie J. Swanson and Victor D. Vacquier

Similar processes mediate glycopeptide export from 6730-6734 the endoplasmic reticulum in mammalian cells and Saccharomyces cerevisiae

Karin Romisch and Bassam R. S. Ali

BIOPHYSICS

Estimation of mean exocytic vesicle capacitance in 6735-6740 mouse adrenal chromaffin cells

Tobias Moser and Erwin Neher

Voltage gating of Escherichia coli porin channels: 6741-6745 Role of the constriction loop

Prashant S. Phale, Tilman Schirmer, Alexej Prilipov, Kuo-Long Lou, Ariane Hardmeyer, and Jurg P. Rosenbusch

CELL BIOLOGY

Identification of a nuclear matrix targeting signal in 6746-6751 the leukemia and bone-related AML/CBF-a transcription factors

Congmei Zeng, Andre J. van Wijnen, Janet L. Stein, Shari Meyers, Wuhua Sun, Lindsay Shopland, Jeanne B. Lawrence, Sheldon Penman, Jane B. Lian, Gary S. Stein, and Scott W. Hiebert

Vacuolar H+-ATPase in ocular ciliary epithelium 6752-6757 Martin B. Wax, Isao Saito, Tatyana Tenkova, Theodore Krupin, Bernard Becker, Nathan Nelson, Dennis Brown, and Stephen L. Gluck

Developmental regulation and the role of insulin and 6758-6763 insulin receptor in metanephrogenesis

Zheng Z. Liu, Anil Kumar, Kosuke Ota, Elisabeth I. Wallner, and Yashpal S. Kanwar

iv

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Page 8: Front Matter

Contents Constitutive activation of a slowly migrating isoform 6764-6769 of Stat3 in mycosis fungoides: Tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines

Mette Nielsen, Keld Kaltoft, Mette Nordahl, Carsten Ropke, Carsten Geisler, Tomas Mustelin, Pauline Dobson, Arne Svejgaard, and Niels 0dum

DEVELOPMENTAL BIOLOGY

Purification and molecular cloning of a secreted, 6770-6775 Frizzled-related antagonist of Wnt action

Paul W. Finch, Xi He, Michael J. Kelley, Aykut Cren, R. Paul Schaudies, Nicholas C. Popescu, Stuart Rudikoff, Stuart A. Aaronson, Harold E. Varmus, and Jeffrey S. Rubin

In vivo repopulating hematopoietic stem cells are 6776-6780 present in the murine yolk sac at day 9.0 postcoitus

Mervin C. Yoder, Kelly Hiatt, and Pinku Mukherjee

A "knockdown" mutation created by cis-element gene 6781-6785 targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1

Michael A. McDevitt, Ramesh A. Shivdasani, Yuko Fujiwara, Haidi Yang, and Stuart H. Orkin

Continuous in vitro propagation of the malaria 6786-6791 parasite Plasmodium vivax

Claudia F. Golenda, Jun Li, and Ronald Rosenberg

ECOLOGY

Defensive production of formic acid (80%) by a 6792-6797 carabid beetle (Galerita lecontei)

Carmen Rossini, Athula B. Attygalle, Andres Gonzalez, Scott R. Smedley, Maria Eisner, Jerrold Meinwald, and Thomas Eisner

EVOLUTION

Evolution subverting essentiality: Dispensability of the 6798-6802 cell attachment Arg-Gly-Asp motif in multiply passaged foot-and-mouth disease virus

Miguel A. Martinez, Nuria Verdaguer, Mauricio G. Mateu, and Esteban Domingo

Ligand binding was acquired during evolution of 6803-6808 nuclear receptors

Hector Escriva, Rachid Safi, Catherine Hanni, Marie-Claire Langlois, Pierre Saumitou-Laprade, Dominique Stehelin, Andre Capron, Raymond Pierce, and Vincent Laudet

DNA sequence evidence for the segmental 6809-6814 allotetraploid origin of maize

Brandon S. Gaut and John F. Doebley

Likelihood-mapping: A simple method to visualize 6815-6819 phylogenetic content of a sequence alignment

Korbinian Strimmer and Arndt von Haeseler

Exon/intron structure of aldehyde dehydrogenase 6820-6825 genes supports the "introns-late" theory

Andrey Rzhetsky, Francisco Jose Ayala, Lily C. Hsu, Cheng Chang, and Akira Yoshida

GENETICS

Construction and characterization of a reovirus 6826-6830 double temperature-sensitive mutant

Michael R. Roner, Igor Nepliouev, Barbara Sherry, and Wolfgang K. Joklik

Selective amplification via biotin- and 6831-6836 restriction-mediated enrichment (SABRE), a novel selective amplification procedure for detection of differentially expressed mRNAs

Daniel J. Lavery, Luis Lopez-Molina, Fabienne Fleury-Olela, and Ueli Schibler

Photocarcinogenesis and inhibition of intercellular 6837-6841 adhesion molecule 1 expression in cells of DNA-repair-defective individuals

Constanze Ahrens, Markus Grewe, Mark Berneburg, Susanne Grether-Beck, Xavier Quilliet, Mauro Mezzina, Alain Sarasin, Alan R. Lehmann, Colin F. Arlett, and Jean Krutmann

Impaired fertility in mice deficient for the testicular 6842-6846 germ-cell protease PC4

Majambu Mbikay, Haidy Tadros, Norito Ishida, Charlie P. Lerner, Eve De Lamirande, Andrew Chen, Mohamed El-Alfy, Yves Clermont, Nabil G. Seidah, Michel Chretien, Claude Gagnon, and Elizabeth M. Simpson

Removal of polymerase-produced mutant sequences 6847-6850 from PCR products

Jane Smith and Paul Modrich

Gene targeting by linear duplex DNA frequently 6851-6856 occurs by assimilation of a single strand that is subject to preferential mismatch correction

W.-Y. Leung, A. Malkova, and J. E. Haber

The distribution of genes in the genomes of Gramineae 6857-6861 Abdelali Barakat, Nicolas Carels, and Giorgio Bemardi

Gene identification and DNA sequence analysis in the 6862-6867 GC-poor 20 megabase region of human chromosome 21

Jingwei Yu, Suhong Tong, Yiping Shen, and Fa-Ten Kao

RecA-like proteins are components of early meiotic 6868-6873 nodules in lily

Lorinda K. Anderson, Hildo H. Offenberg, W. M. H. C. Verkuijlen, and Christa Heyting

IMMUNOLOGY

A critical role for neutralizing-antibody-producing B 6874-6879 cells, CD4+ T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: Implications for adoptive immunotherapy of virus carriers

Oliver Planz, Stephan Ehl, Esther Furrer, Edit Horvath, Marie-Anne Briindler, Hans Hengartner, and Rolf M. Zinkernagel

The three-dimensional structure of an H-2Ld-peptide 6880-6885 complex explains the unique interaction of Ld with beta-2 microglobulin and peptide

Ganesaratnam K. Balendiran, Joyce C. Solheim, Aideen C. M. Young, Ted H. Hansen, Stanley G. Nathenson, and James C. Sacchettini

v

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Page 9: Front Matter

Contents Major histocompatibility complex class II-transfected 6886-6891 tumor cells present endogenous antigen and are potent inducers of tumor-specific immunity

Todd D. Armstrong, Virginia K. Clements, Brian K. Martin, Jenny P.-Y. Ting, and Suzanne Ostrand-Rosenberg

Selective binding of bacterial toxins to major 6892-6897 histocompatibility complex class II-expressing cells is controlled by invariant chain and HLA-DM

Pascal M. Lavoie, Jacques Thibodeau, Isabelle Cloutier, Robert Busch, and Rafick-P. S6kaly

Ly-6C regulates endothelial adhesion and homing of 6898-6903 CD8+ T cells by activating integrin-dependent adhesion pathways

Arno Hanninen, Ilkka Jaakkola, Marko Salmi, Olli Simell, and Sirpa Jalkanen

The human cytomegalovirus US6 glycoprotein inhibits 6904-6909 transporter associated with antigen processing-dependent peptide translocation

Paul J. Lehner, Jaana T. Karttunen, Gavin W. G. Wilkinson, and Peter Cresswell

The amino terminus of JAK3 is necessary and sufficient 6910-6915 for binding to the common y chain and confers the ability to transmit interleukin 2-mediated signals

Min Chen, Alan Cheng, Yi-Qing Chen, Anka Hymel, Eric P. Hanson, Lida Kimmel, Yasuhiro Minami, Tadatsugu Taniguchi, Paul S. Changelian, and John J. O'Shea

MEDICAL SCIENCES

Efficient photoreceptor-targeted gene expression 6916-6921 in vivo by recombinant adeno-associated virus

John G. Flannery, Sergei Zolotukhin, M. Isabel Vaquero, Matthew M. LaVail, Nicholas Muzyczka, and William W. Hauswirth

Effect of tissue factor deficiency on mouse and 6922-6926 tumor development

John R. Toomey, Kenneth E. Kratzer, Nina M. Lasky, and George J. Broze, Jr.

RAB22 and RAB163/mouse BRCA2: Proteins that 6927-6932 specifically interact with the RAD51 protein

Ryushin Mizuta, Janine M. LaSalle, Hwei-Ling Cheng, Akira Shinohara, Hideyuki Ogawa, Neal Copeland, Nancy A. Jenkins, Marc Lalande, and Frederick W. Alt

Loss of the retinoblastoma protein-related p130 6933-6938 protein in small cell lung carcinoma

Kristian Helin, Karin Holm, Anita Niebuhr, Hans Eiberg, Niels Tommerup, Susanne Hougaard, Hans Skovgaard Poulsen, Mogens Spang-Thomsen, and Peter Norgaard

Role for Bcl-XL as an inhibitor of cytosolic 6939-6942 cytochrome C accumulation in DNA damage-induced apoptosis

Surender Kharbanlda, Pramod Pandey, Lesley Schofield, Sara Israels, Richard Roncinske, Kiyotsugu Yoshida, Ajit Bharti, Zhi-Min Yuan, Satya Saxena, Ralph Weichselbaum, Carlo Nalin, and Donald Kufe

Dwarfism and age-associated spinal degeneration of 6943-6947 heterozygote cmd mice defective in aggrecan

Hideto Watanabe, Ken Nakata, Koji Kimata, Isao Nakanishi, and Yoshihiko Yamada

Molecular delineation of the smallest commonly 6948-6953 deleted region of chromosome 5 in malignant myeloid diseases to 1-1.5 Mb and preparation of a PAC-based physical map

Nanding Zhao, Archontoula Stoffel, Pauline W. Wang, James D. Eisenbart, Rafael Espinosa III, Richard A. Larson, and Michelle M. Le Beau

Superoxide and peroxynitrite generation from 6954-6958 inducible nitric oxide synthase in macrophages

Yong Xia and Jay L. Zweier

Cloning and characterization of the Rl and R2 6959-6964 subunits of ribonucleotide reductase from Trypanosoma brucei

Anders Hofer, Peter P. Schmidt, Astrid Graslund, and Lars Thelander

Homo- and heterodimeric interactions between the 6965-6970 gene products of PKDI and PKD2

Leonidas Tsiokas, Emily Kim, Thierry Arnould, Vikas P. Sukhatme, and Gerd Walz

Virus dynamics and drug therapy 6971-6976 Sebastian Bonhoeffer, Robert M. May, George M. Shaw, and Martin A. Nowak

MICROBIOLOGY

An intestinal mucin is the target substrate for a 6977-6982 baculovirus enhancin

Ping Wang and Robert R. Granados

NEUROBIOLOGY

Novel expression mechanism for synaptic potentiation: 6983-6988 Alignment of presynaptic release site and postsynaptic receptor

Xiaping Xie, Jim-Shih Liaw, Michel Baudry, and Theodore W. Berger

"Willed action": A functional MRI study of the 6989-6994 human prefrontal cortex during a sensorimotor task

Fahmeed Hyder, Elizabeth A. Phelps, Christopher J. Wiggins, Kevin S. Labar, Andrew M. Blamire, and Robert G. Shulman

Area-specific regulation of -y-aminobutyric acid type A 6995-7000 receptor subtypes by thalamic afferents in developing rat neocortex

Jacques Paysan, Albrecht Kossel, Jurgen Bolz, and Jean-Marc Fritschy

Anatomic localization of alternatively spliced leptin 7001-7005 receptors (Ob-R) in mouse brain and other tissues

Hong Fei, Hirotaka J. Okano, Cai Li, Gwo-Hwa Lee, Connie Zhao, Robert Darnell, and Jeffrey M. Friedman

Heat transduction in rat sensory neurons by 7006-7011 calcium-dependent activation of a cation channel

David B. Reichling and Jon D. Levine

vi

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Page 10: Front Matter

Contents Extracellular calcium sensed by a novel cation channel 7012-7017 in hippocampal neurons

Z.-G. Xiong, W.-Y. Lu, and J. F. MacDonald

Neurturin shares receptors and signal transduction 7018-7023 pathways with glial cell line-derived neurotrophic factor in sympathetic neurons

Douglas J. Creedon, Malu G. Tansey, Robert H. Baloh, Patricia A. Osborne, Patricia A. Lampe, Timothy J. Fahrner, Robert 0. Heuckeroth, Jeffrey Milbrandt, and Eugene M. Johnson, Jr.

Glutamine synthetase protects against neuronal 7024-7029 degeneration in injured retinal tissue

Rena Gorovits, Nili Avidan, Noa Avisar, Iftach Shaked, and Lily Vardimon

Membrane-associated molecules regulate the 7030-7035 formation of layer-specific cortical circuits

Valerie Castellani and Jurgen Bolz

In vivo activity-dependent plasticity at cortico-striatal 7036-7040 connections: Evidence for physiological long-term potentiation

S. Charpier and J. M. Deniau

Involvement of hippocampal cAMP/cAMP-dependent 7041-7046 protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats

Ramon Bernabeu, Lia Bevilaqua, Patricia Ardenghi, Elke Bromberg, Paulo Schmitz, Marino Bianchin, Ivan Izquierdo, and Jorge H. Medina

A 10-amino acid sequence of fibroblast growth factor 7047-7052 2 is sufficient for its mitogenic activity on neural progenitor cells

Jasodhara Ray, Andrew Baird, and Fred H. Gage

PHARMACOLOGY

7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 7053-7058 S,S-dioxide: A partial modulator of AMPA receptor desensitization devoid of neurotoxicity

F. Impagnatiello, A. Oberto, P. Longone, E. Costa, and A. Guidotti

PHYSIOLOGY

Molecular characterization of the sodium channel 7059-7064 subunits expressed in mammalian cerebellar Purkinje cells

Eleazar Vega-Saenz de Miera, Bernardo Rudy, Mutsuyuki Sugimori, and Rodolfo Llinas

Relationships between enzymatic flux capacities and 7065-7069 metabolic flux rates: Nonequilibrium reactions in muscle glycolysis

R. K. Suarez, J. F. Staples, J. R. B. Lighton, and T. G. West

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INFORMATION FOR AUTHORS

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CLASSIFIED ADVERTISEMENTS

Activation of heteromeric G protein-gated inward 7070-7075 rectifier K+ channels overexpressed by adenovirus gene transfer inhibits the excitability of hippocampal neurons

Markus U. Ehrengruber, Craig A. Doupnik, Youfeng Xu, Justine Garvey, Mark C. Jasek, Henry A. Lester, and Norman Davidson

PLANT BIOLOGY

The AP2 domain of APE TALA2 defines a large new 7076-7081 family of DNA binding proteins inArabidopsis

Jack K. Okamuro, Brian Caster, Raimundo Villarroel, Marc Van Montagu, and K. Diane Jofuku

Stress proteins on the yeast cell surface determine 7082-7087 resistance to osmotin, a plant antifungal protein

Dae-Jin Yun, Yuan Zhao, Jose M. Pardo, Meena L. Narasimhan, Barbara Damsz, Hyeseung Lee, Laura R. Abad, Matilde Paino D'Urzo, Paul M. Hasegawa, and Ray A. Bressan

A novel subviral agent associated with a geminivirus: 7088-7093 The first report of a DNA satellite

Ian B. Dry, Leslie R. Krake, Justin B. Rigden, and M. Ali Rezaian

Expression of a mutant ax-zein creates the floury2 7094-7097 phenotype in transgenic maize

Craig B. Coleman, Amy M. Clore, Jerry P. Ranch, Regina Higgins, Mauricio A. Lopes, and Brian A. Larkins

Overexpression of an Arabidopsis thaliana high-affinity 7098-7102 phosphate transporter gene in tobacco cultured cells enhances cell growth under phosphate-limited conditions

Norihiro Mitsukawa, Satoru Okumura, Yumiko Shirano, Shigeru Sato, Tomohiko Kato, Satoshi Harashima, and Daisuke Shibata

Purified vesicles of tobacco cell vacuolar and plasma 7103-7108 membranes exhibit dramatically different water permeability and water channel activity

Christophe Maurel, Frederique Tacnet, Josette Guiclui, Jean Guern, and Pierre Ripoche

PSYCHOLOGY

The hippocampus and memory for orderly 7109-7114 stimulus relations

Jeffery A. Dusek and Howard Bichenbaum

Spatial and temporal coherence in perceptual binding 7115-7119 Randolph Blake and Yuede Yang

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