Front Matter Source: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, No. 24 (Nov. 25, 1997), pp. i-xiii Published by: National Academy of Sciences Stable URL: http://www.jstor.org/stable/43474 . Accessed: 07/05/2014 20:56 Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at . http://www.jstor.org/page/info/about/policies/terms.jsp . JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact [email protected]. . National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access to Proceedings of the National Academy of Sciences of the United States of America. http://www.jstor.org This content downloaded from 169.229.32.136 on Wed, 7 May 2014 20:56:30 PM All use subject to JSTOR Terms and Conditions
Transcript
Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 94, No. 24 (Nov. 25, 1997), pp. i-xiiiPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/43474 .
Accessed: 07/05/2014 20:56
Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at .http://www.jstor.org/page/info/about/policies/terms.jsp
.JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range ofcontent in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new formsof scholarship. For more information about JSTOR, please contact [email protected].
.
National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access toProceedings of the National Academy of Sciences of the United States of America.
http://www.jstor.org
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 20:56:30 PMAll use subject to JSTOR Terms and Conditions
Come visit us at ASCB Booth #'s 624, 626, 725, and 727. The ApoAlert CPP32 Fluorescent and Colorimetric Protease Assay Kits (#K2026-1, -2, #K2027-1, -2) provide convenient means of detecting CPP32 activity. CPP32 is an ICE-family protease implicated in initiating apoptosis in a variety of systems.
The ApoAlert Annexin V Apoptosis Kit (#K2025-1, -2) quickly and easily detects an early apoptosis indicator-the translocation of phosphatidylserine to the outer leaflet of the plasma membrane.
CLONTECH also offers the ApoAlert DNA Fragmentation Assay and a variety of apoptosis-inducing reagents, inhibitors, and antibodies. Call 800-662-CLON (2566) or contact your local distributor.
CLONTECH N O W Y O U C A N. 1020 East Meadow Circle, Palo Alto, California 94303 USA
*RiboQuantm RNase Protection Assay System for human and mouse apoptosis mRNA detection and quantitation Please contact us for a complete listing of available products for apoptosis research. For technical assistance call: -To place an -order call:
-~~~~~~~~~~~~~~~80 TAK-E (2-8)(0)84MAS627 v~ ~ ~ ~ ~ ~~~~~~~ ~ii us on he Web
Susdais Geran PhrignGb hrignItratoa tpIwwpamne.
Diagostc 0y (no13)t 6822osl-758ct memFrance CaniScienclrpoeis: (1 453 14: 53 * Grec Farae (1 6451 : ni Im un Diagnotics (3)2283 Israe ENCD Scietifi (03) 934-9922 Kit,alynmuod(2 57604555 V JapagntFjsaw Pharmaceuticaln C po., ptd. t10975lTorryan Roadytmer
NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Officers BRUCE ALBERTS, President of the JACK HALPERN, Vice President Academy PETER H. RAVEN, Home Secretary
F. SHERWOOD ROWLAND, Foreign Secretary RONALD L. GRAHAM, Treasurer
Editor-in-Chief NICHOLAS R. COZZARELLI
Editorial Board of the Proceedings
PETER J. BICKEL WILLIAM CATTERALL ANTHONY CERAMI PIERRE CHAMBON MICHAEL T. CLEGG MARSHALL H. COHEN STANLEY N. COHEN DAVID R. DAVIES HERMAN N. EISEN RAYMOND L. ERIKSON ANTHONY S. FAUCI NINA FEDOROFF
CHARLES FEFFERMAN JOSEPH L. GOLDSTEIN CAROL A. GROSS JACK HALPERN PIERRE C. HOHENBERG BERTIL HILLE H. ROBERT HORVITZ ROGER KORNBERG ROBERT LANGER HARVEY F. LODISH PHIL W. MAJERUS
PHILIPPA MARRACK ARNO G. MOTIJLSKY RONALD L. PHILLIPS TOM POLLARD STANLEY B. PRUSINER CHARLES RADDING GIAN-CARLO ROTA JEREMY A. SABLOFF PAUL R. SCHIMMEL STUART L. SCHREIBER AARON J. SHATKIN
CARLA J. SHATZ KAI L. SIMONS CHRISTOPHER A. SIMS CHRISTOPHER R. SOMERVILLE ALLAN C. SPRADLING LARRY R. SQUIRE CHARLES F. STEVENS FRANK H. STILLINGER JOANNE STUBBE KARL K. TUREKIAN DON C. WILEY PETER G. WOLYNES
Publisher: Managing Editor: Associate Editorial Manager: Associate Manager for Production: Production Coordinator: Editorial Coordinator: System Administrator: Manuscript Coordinator: Financial Assistant: Business and Marketing Assistant: Subscription Fulfillment Assistant: Secretary: Administrative Assistants:
KENNETH R. FULTON DIANE M. SULLENBERGER JOHN M. MALLOY JOANNE D'AMIco BARBARA A. BACON THOR RUNEMAN MARILYN J. MASON DANIEL H. SALSBURY JULIA A. LITTLE ROBERT J. BENN, JR. CYNTHIA MATHEWS BRENDA L. MCCOY AZADEH FULLMER JESSAMINE PRICE
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (ISSN-0027-8424) is published biweekly by THE NATIONAL ACADEMY OF SCIENCES.
Correspondence: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, NW, Washington, DC 20418 USA (via U.S. postal service) or 1055 Thomas Jefferson Street, NW, Suite FO2013, Washington, DC 20007 USA (via courier or express mail). E-mail: [email protected]. Information for Authors: See pp. xviii-xx (of this issue) or http://www.pnas.org. Copyright: Volumes 90-94, copyright C) 1993-1997 by THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, all rights reserved; Volumes 1-89, copyright as a collective work only [author(s) retains copyright to individual articles]. Requests for Permission: Address requests to reproduce material published in Volumes 1-89 to the original author(s); address other requests to the Permissions Office of the PROCEEDINGS, 2101 Constitution Avenue, NW, Washington, DC 20418 USA, FAX 202-625-4749. Please cite the exact material to be reprinted and state specifically where it will be used. Photocopies: The journal is registered with the Copyright Clearance Center, 222 Rosewood Drive, Danvers, MA 01923 USA, FAX 978-750-4470. Authorization to photocopy items for the internal or personal use of specific clients is granted by THE NATIONAL ACADEMY OF SCIENCES provided that the copier pays to the Center the fee stated in the code on the first page of each article. Microforms: Contact University Microfilms Inc., P.O. Box 1346, Ann Arbor, MI 48106-1346 USA. This journal is printed on acid-free paper effective with Volume 84, Issue 1. Subscriptions: Address subscription correspondence to the Circulation Office of the PROCEEDINGS, 2101 Constitution Avenue, NW, Washington, DC 20418 USA. Subscriptions are entered on a calendar-year basis only. The 1997 subscription rates are as follows-in the U.S.: student, $90; postdoctoral, $125; personal, $150; institutional, $615-elsewhere by surface mail: student, $190; postdoctoral, $225; personal, $250; institutional, $715-elsewhere by expedited delivery at a surcharge of $234. Air mail rates available on request. Exclusive Agent for Subscribers in Japan: USACO Corporation, 13-12, Shimbashi, 1-Chome, Minato-ku, Tokyo 105 Japan. Change of Address: Notify the Circulation Office 6 weeks in advance and list the old and new addresses. The Academy is not responsible for nonreceipt of issues because of an improper address, unless a change of address is on file. Claims: Requests for replacement copies will not be honored more than 60 days after the issue date for domestic subscribers and not more than 90 days after the issue date for foreign subscribers. Claims will not be honored for more than 2 issues per calendar year for the same subscriber. Single Copies: $30 per issue in the U.S., $40 elsewhere. Canadian GST: Registration Number R-133130880. Advertising: Contact FASEB AdNet, 9650 Rockville Pike, Bethesda, MD 20814-3998 USA. Phone 800-43-FASEB X7103 or 301-530-7103, FAX 301-571-0683. Postmaster: Send address changes to PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, NW, Washington, DC 20418 USA. Periodicals postage paid at Washington, DC, and additional mailing offices. PRINTED IN THE UJSA
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES is also available online at http://www.pnas.org. Cover photograph: Bronze embossed doors at the entrance to the NationalAcademy of Sciences depicting major figures in science. This section features Galileo, Newton, Lyell, Darwin, Watt, and Pasteur. Created by Lee Lawrie (1923).
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 20:56:30 PMAll use subject to JSTOR Terms and Conditions
NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
November 25, 1997 Volume 94, Number 24 pp. 12733-13374
Table of Contents
From the Academy
Introduction to German-American Frontiers of 12733 Science
Approximation algorithms 12734-12735 Andreas S. Schulz, David B. Shmoys, and David P. Williamson
Advances in apoptosis research 12736-12737 Marcus E. Peter, Armin E. Heufelder, and Michael 0. Hengartner
Encoding strategies in combinatorial chemistry 12738-12739 A. W. Czarnik
Neural codes: Firing rates and beyond 12740-12741 Wulfram Gerstner, Andreas K. Kreiter, Henry Markram, and Andreas V. M. Herz
Core geophysics 12742-12743 Bradford M. Clement, Astrid Holzheid, and Andreas Tilgner
Gene therapy 12744-12746 Mark A. Kay, Dexi Liu, and Peter M. Hoogerbrugge
Motor proteins of the eukaryotic cytoskeleton 12747-12748 M. Andrew Hoyt, Anthony A. Hyman, and Martin Bahler
Scanning-probe-based science and technology 12749-12750 Roland Wiesendanger
Commentaries
Fun with genealogy 12751-12753 W. Ford Doolittle
Life without DNA repair 12754-12757 David M. Wilson III and Larry H. Thompson
Origins of mRNA identity: Capping enzymes bind to 12758-12760 the phosphorylated C-terminal domain of RNA polymerase II
Stewart Shuman
The elusive singularity 12761 Peter Constantin
Inaugural Articles
The diversity and evolutionary relationships of the 12809-12816 pregnancy-associated glycoproteins, an aspartic proteinase subfamily consisting of many trophoblast-expressed genes
Sancai Xie, Jonathan Green, James B. Bixby, Bozena Szafranska, James C. DeMartini, Steven Hecht, and R. Michael Roberts
v
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 20:56:30 PMAll use subject to JSTOR Terms and Conditions
Contents In vivo functions of the Saccharomyces cerevisiae 12949-12956 Hsp9O chaperone
Debra F. Nathan, Melissa Harju Vos, and Susan Lindquist
Neurotrophin release by neurotrophins: Implications 13279-13286 for activity-dependent neuronal plasticity
Marco Canossa, Oliver Griesbeck, Benedikt Berninger, Gabriele Campana, Roland Kolbeck, and Hans Thoenen
Appendicular robusticity and the paleobiology of 13367-13373 modern human emergence
Erik Trinkaus
Physical Sciences
APPLIED MATHEMATICS
The influence of the flow of the reacting gas on the 12762-12764 conditions for a thermal explosion
G. I. Barenblatt, A. J. Chorin, and A. Kast
CHEMISTRY
Twist grain boundaries in three-dimensional lamellar 12765-12768 Turing structures
A. De Wit, P. Borckmans, and G. Dewel
MATHEMATICS
On the geometry of solutions of the quasi-geostrophic 12769-12770 and Euler equations
Diego Cordoba
PHYSICS
Filamentary microstructure and linear temperature 12771-12775 dependence of normal state transport in optimized high temperature superconductors
J. C. Phillips
STATISTICS
Estimating the probability of initiated cell death 12776-12779 before tumor induction
Kenneth M. Boucher and Andrej Y. Yakovlev
Biological Sciences
AGRICULTURAL SCIENCES
Global variation in the genetic and biochemical basis 12780-12785 of diamondback moth resistance to Bacillus thuringiensis
Bruce B. Tabashnik, Yong-Biao Liu, Thomas Malvar, David G. Heckel, Luke Masson, Victoria Ballester, Francisco Granero, Jose L. Mensua, and Juan Ferre
BIOCHEMISTRY
Estrogenic responses in estrogen receptor-a deficient 12786-12791 mice reveal a distinct estrogen signaling pathway
S. K. Das, Julia A. Taylor, Kenneth S. Korach, B. C. Paria, S. K. Dey, and Dennis B. Lubahn
KSR stimulates Raf-1 activity in a 12792-12796 kinase-independent manner
Neil R. Michaud, Marc Therrien, Angela Cacace, Lisa C. Edsall, Sarah Spiegel, Gerald M. Rubin, and Deborah K. Morrison
A link between protein structure and enzyme 12797-12802 catalyzed hydrogen tunneling
Brian J. Bahnson, Thomas D. Colby, Jodie K. Chin, Barry M. Goldstein, and Judith P. Klinman
The carbamate kinase-like carbamoyl phosphate 12803-12808 synthetase of the hyperthermophilic archaeon Pyrococcus furiosus, a missing link in the evolution of carbamoyl phosphate biosynthesis
Virginie Durbecq, Christianne Legrain, Martine Roovers, Andre Pi6rard, and Nicolas Glansdorff
The diversity and evolutionary relationships of the 12809-12816 pregnancy-associated glycoproteins, an aspartic proteinase subfamily consisting of many trophoblast-expressed genes
Sancai Xie, Jonathan Green, James B. Bixby, Bozena Szafranska, James C. DeMartini, Steven Hecht, and R. Michael Roberts
Localization and activity of lysyl oxidase within nuclei 12817-12822 of fibrogenic cells
Wande Li, Kaliappanadar Nellaiappan, Timothy Strassmaier, Lila Graham, Kathleen M. Thomas, and Herbert M. Kagan
Identification of specific Rp-phosphate oxygens in the 12823-12828 tRNA anticodon loop required for ribosomal P-site binding
Wolfgang Schnitzer and Uwe von Ahsen
Recruitment of IRAK to the interleukin 1 receptor 12829-12832 complex requires interleukin 1 receptor accessory protein
Jianing Huang, Xiong Gao, Shyun Li, and Zhaodan Cao
Isolation and bacterial expression of a sesquiterpene 12833-12838 synthase cDNA clone from peppermint (Mentha x piperita, L.) that produces the aphid alarm pheromone (E)-13-farnesene
John Crock, Mark Wildung, and Rodney Croteau
Anti-idiotype RNA selected with an anti-nuclear 12839-12844 export signal antibody is actively transported in oocytes and inhibits Rev- and cap-dependent RNA export
J6rg Hamm, Jochen Huber, and Reinhard Liihrmann
Functional analysis of DNA bending and unwinding 12845-12850 by the high mobility group domain of LEF-1
Klaus Giese, John Pagel, and Rudolf Grosschedl
Inhibition of regulator of G protein signaling function 12851-12856 by two mutant RGS4 proteins
Kirk M. Druey and John H. Kehrl
vii
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 20:56:30 PMAll use subject to JSTOR Terms and Conditions
Contents Identification of a thiamin-dependent synthase in 12857-12862 Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol
Georg A. Sprenger, Ulrich Schorken, Thomas Wiegert, Sigrid Grolle, Albert A. de Graaf, Sean V. Taylor, Tadhg P. Begley, Stephanie Bringer-Meyer, and Hermann Sahm
An interaction between DNA ligase I and 12863-12868 proliferating cell nuclear antigen: Implications for Okazaki fragment synthesis and joining
David S. Levin, Wei Bai, Nina Yao, Michael O'Donnell, and Alan E. Tomkinson
Targeted deletion of alkylpurine-DNA-N-glycosylase 12869-12874 in mice eliminates repair of 1,N6-ethenoadenine and hypoxanthine but not of 3,N4-ethenocytosine or 8-oxoguanine
B. Hang, B. Singer, G. P. Margison, and R. H. Elder
Construction of a Z-DNA-specific 12875-12879 restriction endonuclease
Yang-Gyun Kim, Pearl S. Kim, Alan Herbert, and Alexander Rich
Disruption of the murine gene encoding 12880-12885 phosphatidylethanolamine N-methyltransferase
Christopher J. Walkey, Leah Rae Donohue, Rod Bronson, Luis B. Agellon, and Dennis E. Vance
Myc represses transcription of the growth arrest 12886-12891 gene gasl
Theodore C. Lee, Linheng Li, Lennart Philipson, and Edward B. Ziff
Proteins on ribosome surface: Measurements 12892-12897 of protein exposure by hot tritium bombardment technique
Dmitry E. Agafonov, Vyacheslav A. Kolb, and Alexander S. Spirin
Mammalian capping enzyme complements mutant 12898-12903 Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II
Zhenyu Yue, Edio Maldonado, Renuka Pillutla, Helen Cho, Danny Reinberg, and Aaron J. Shatkin
Inhibition of NF-KB DNA binding and nitric oxide 12904-12907 induction in human T cells and lung adenocarcinoma cells by selenite treatment
Ick Young Kim and Thressa C. Stadtman
P-glycoprotein function involves conformational 12908-12913 transitions detectable by differential immunoreactivity
Eugene B. Mechetner, Brigitte Schott, Brian S. Morse, Wilfred D. Stein, Todd Druley, Kenneth A. Davis, Takashi Tsuruo, and Igor B. Roninson
cAMP receptor protein-cAMP plays a crucial role in 12914-12919 glucose-lactose diauxie by activating the major glucose transporter gene in Escherichia co/i
Cloning and expression of rat 25-hydroxyvitamin 12920-12925 D3-la-hydroxylase cDNA
Toshimasa Shinki, Hiroko Shimada, Shu Wakino, Hideharu Anazawa, Matsuhiko Hayashi, Takao Saruta, Hector F. DeLuca, and Tatsuo Suda
Cloning and expression of a .cDNA encoding a 12926-12931 bovine brain brefeldin A-sensitive guanine nucleotide-exchange protein for ADP- ribosylation factor
Naoko Morinaga, Joel Moss, and Martha Vaughan
CELL BIOLOGY
Phagocytosis of rod outer segments by retinal pigment 12932-12937 epithelial cells requires av/35 integrin for binding but not for internalization
Silvia C. Finnemann, Vera L. Bonilha, Alan D. Marmorstein, and Enrique Rodriguez-Boulan
Smad8 mediates the signaling of the receptor 12938-12943 serine kinase
Yan Chen, Anil Bhushan, and Wylie Vale
Ubiquitin-mediated regulation of 12944-12948 3-hydroxy-3-methylglutaryl-CoA reductase
Randolph Y. Hampton and Hetal Bhakta
In vivo functions of the Saccharomyces cerevisiae 12949-12956 Hsp9O chaperone
Debra F. Nathan, Melissa Harju Vos, and Susan Lindquist
The phosphorylation state of the FIGQY tyrosine of 12957-12962 neurofascin determines ankyrin-binding activity and patterns of cell segregation
Shmuel Tuvia, Timothy D. Garver, and Vann Bennett
Genghis Khan (Gek) as a putative effector for 12963-12968 Drosophila Cdc42 and regulator of actin polymerization
Liqun Luo, Tzumin Lee, Linus Tsai, Gale Tang, Lily Y. Jan, and Yuh Nung Jan
Erythrocyte membrane vesiculation: Model for the 12969-12974 molecular mechanism of protein sorting
David W. Knowles, Leann Tilley, Narla Mohandas, and Joel Anne Chasis
Coordinate regulation of lipogenic gene expression by 12975-12980 androgens: Evidence for a cascade mechanism involving sterol regulatory element binding proteins
Johannes V. Swinnen, William Ulrix, Walter Heyns, and Guido Verhoeven
Identification of a family of low-affinity insulin-like 12981-12986 growth factor binding proteins (IGFBPs): Characterization of connective tissue growth factor as a member of the IGFBP superfamily
Ho-Seong Kim, Srinivasa R. Nagalla, Youngman Oh, Elizabeth Wilson, Charles T. Roberts, Jr., and Ron G. Rosenfeld
viii
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 20:56:30 PMAll use subject to JSTOR Terms and Conditions
Ol-Prx 3, a member of an additional class of 12987-12992 homeobox genes, is unimodally expressed in several domains of the developing and adult central nervous system of the medaka (Oryzias latipes)
Jean-Stephane Joly, Franck Bourrat, Van Nguyen, and Daniel Chourrout
Homeobox gene Piw3 expression in rodent brain and 12993-12998 extraneural tissues
Hermien S. A. van Schaick, Marten P. Smidt, Alessandra Cecilia Rovescalli, Mirjam Luijten, Arno A. M. van der Kleij, Sadamitsu Asoh, Christine A. Kozak, Marshall Nirenberg, and J. Peter H. Burbach
Genes regulated by androgen in the rat 12999-13004 ventral prostate
Zhou Wang, Rachel Tufts, Riffat Haleem, and Xiaoyan Cai
The N terminus of the Drosophila Numb protein 13005-13010 directs membrane association and actin-dependent asymmetric localization
Juergen A. Knoblich, Lily Y. Jan, and Yuh Nung Jan
The role of thyroid hormone in zebrafish and 13011-13016 axolotl development
Donald D. Brown
Siamois is required for formation of 13017-13022 Spemann's organizer
Daniel S. Kessler
ECOLOGY
Primate species richness is determined by plant 13023-13027 productivity: Implications for conservation
Richard F. Kay, Richard H. Madden, Carel Van Schaik, and David Higdon
EVOLUTION
Determining divergence times with a protein clock: 13028-13033 Update and reevaluation
Da-Fei Feng, Glen Cho, and Russell F. Doolittle
Rapid decline of fitness in panmictic populations of 13034-13039 Drosophila melanogaster maintained under relaxed natural selection
Svetlana A. Shabalina, Lev Yu. Yampolsky, and Alexey S. Kondrashov
Plasmodium falciparum antigenic diversity: Evidence 13040-13045 of clonal population structure
Stephen M. Rich, Richard R. Hudson, and Francisco J. Ayala
A gene-culture coevolutionary model for 13046-13050 brother-sister mating
Kenichi Aoki and Marcus W. Feldman
GENETICS
Sequence variation in the Fanconi anemia gene FAIA 13051-13056 Orna Levran, Tamar Erlich, Neiva Magdalena, John J. Gregory, Sat Dev Batish, Peter C. Verlander, and Arleen D. Auerbach
Yeast microarrays for genome wide parallel genetic 13057-13062 and gene expression analysis
Deval A. Lashkari, Joseph L. DeRisi, John H. McCusker, Allen F. Namath, Cristl Gentile, Seung Y. Hwang, Patrick 0. Brown, and Ronald W. Davis
Analysis of a peptide hormone-receptor interaction 13063-13068 in the yeast two-hybrid system
Jianwei Zhu and C. Ronald Kahn
The Tabby phenotype is caused by mutation in a 13069-13074 mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains
Anand K. Srivastava, Johanna Pispa, Andrew J. Hartung, Yangzhu Du, Sini Ezer, Ted Jenks, Tokihiko Shimada, Maija Pekkanen, Marja L. Mikkola, Minoru S. H. Ko, Irma Thesleff, Juha Kere, and David Schlessinger
Multiple protein domains determine the cell 13075-13080 type-specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editing
Yi Yang, Yan Yang, and Harold C. Smith
The yeast Cacl protein is required for the stable 13081-13086 inheritance of transcriptionally repressed chromatin at telomeres
Ellen K. Monson, Derik de Bruin, and Virginia A. Zakian
Base excision repair deficient mice lacking the Aag 13087-13092 alkyladenine DNA glycosylase
Bevin P. Engelward, Geert Weeda, Michael D. Wyatt, Jose L. M. Broekhof, Jan de Wit, Ingrid Donker, James M. Allan, Barry Gold, Jan H. J. Hoeijmakers, and Leona D. Samson
All cyclophilins and FK506 binding proteins are, 13093-13098 individually and collectively, dispensable for viability in Saccharomyces cerevisiae
Kara Dolinski, Scott Muir, Maria Cardenas, and Joseph Heitman
A network of interacting transcriptional regulators 13099-13104 involved in Drosophila neural fate specification revealed by the yeast two-hybrid system
Pavlos Alifragis, Gretchen Poortinga, Susan M. Parkhurst, and Christos Delidakis
Molecular characterization of four induced alleles at 13105-13110 the Ednrb locus
Myung K. Shin, Liane B. Russell, and Shirley M. Tilghman
TnTIN and TnTAP: Mini-transposons for site-specific 13111-13115 proteolysis in vivo
Michael Ehrmann, Petra Bolek, Martin Mondigler, Dana Boyd, and Roland Lange
Direct repeat sequences in the Streptomyces 13116-13121 chitinase-63 promoter direct both glucose repression and chitin induction
Xiangyang Ni and Janet Westpheling
Recombination-dependent deletion formation in 13122-13127 mammalian cells deficient in the nucleotide excision repair gene ERCC1
R. Geoffrey Sargent, Rhonda L. Rolig, April E. Kilburn, Gerald M. Adair, John H. Wilson, and Rodney S. Nairn
ix
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 20:56:30 PMAll use subject to JSTOR Terms and Conditions
Genetically targeted cell disruption in 13128-13133 Caenorhabditis elegans
S. Harbinder, Nektarios Tavernarakis, Laura A. Herndon, Maud Kinnell, Si Qun Xu, Andrew Fire, and Monica Driscoll
IMMUNOLOGY
Preassembly of interleukin 2 (IL-2) receptor subunits 13134-13139 on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: A fluorescence resonance energy transfer study
Sandor Damjanovich, Laszl6 Bene, Janos Matk6, Abdelkrim Alileche, Carolyn K. Goldman, Susan Sharrow, and Thomas A. Waldmann
Natural killer cell lines kill autologous 13140-13145 02-microglobulin-deficient melanoma cells: Implications for cancer immunotherapy
Angel Porgador, Ofer Mandelboim, Nicholas P. Restifo, and Jack L. Strominger
Heat shock fusion proteins as vehicles for antigen 13146-13151 delivery into the major histocompatibility complex class I presentation pathway
Kimiko Suzue, Xianzheng Zhou, Herman N. Eisen, and Richard A. Young
Btk dosage determines sensitivity to B cell antigen 13152-13157 receptor cross-linking
Anne B. Satterthwaite, Hilde Cheroutre, Wasif N. Khan, Pascalis Sideras, and Owen N. Witte
CD19 and CD22 expression reciprocally regulates 13158-13162 tyrosine phosphorylation of Vav protein during B lymphocyte signaling
Shinichi Sato, Paul J. Jansen, and Thomas F. Tedder
Interaction between HLA-DM and HLA-DR involves 13163-13168 regions that undergo conformational changes at lysosomal pH
H. Joachim Ullrich, Klaus D6ring, Ulrike Gruineberg, Fritz Jahnig, John Trowsdale, and S. Marieke van Ham
Preferential activation of the p46 isoform of 13169-13174 JNK/SAPK in mouse macrophages by TNFa
Edward D. Chan, Brent W. Winston, Matthew B. Jarpe, Murry W. Wynes, and David W. H. Riches
MEDICAL SCIENCES
Interleukin 9: A candidate gene for asthma 13175-13180 Nicholas C. Nicolaides, Kenneth J. Holroyd, Susan L. Ewart, Scott M. Eleff, Matthew B. Kiser, Carl R. Dragwa, Christine D. Sullivan, Luigi Grasso, Liu-Yi Zhang, Carol J. Messler, Tingyi Zhou, Steven R. Kleeberger, Kenneth H. Buetow, and Roy C. Levitt
The Ri component of mammalian ribonucleotide 13181-13186 reductase has malignancy-suppressing activity as demonstrated by gene transfer experiments
Huizhou Fan, Aiping Huang, Cristy Villegas, and Jim A. Wright
Impaired granulopoiesis, myelodysplasia, and early 13187-13192 lethality in CCAAT/enhancer binding protein e-deficient mice
Ryuya Yamanaka, Carrolee Barlow, Julie Lekstrom-Himes, Lucio H. Castilla, Pu P. Liu, Michael Eckhaus, Thomas Decker, Anthony Wynshaw-Boris, and Kleanthis G. Xanthopoulos
Presence of an inducible HIV-1 latent reservoir 13193-13197 during highly active antiretroviral therapy
Tae-Wook Chun, Lieven Stuyver, Stephanie B. Mizell, Linda A. Ehler, Jo Ann M. Mican, Michael Baseler, Alun L. Lloyd, Martin A. Nowak, and Anthony S. Fauci
Association of the transferrin receptor in human 13198-13202 placenta with HFE, the protein defective in hereditary hemochromatosis
Seppo Parkkila, Abdul Waheed, Robert S. Britton, Bruce R. Bacon, Xiao Yan Zhou, Shunji Tomatsu, Robert E. Fleming, and William S. Sly
Loss of ovarian function promotes angiogenesis in 13203-13208 human ovarian carcinoma
Yael S. Schiffenbauer, Rinat Abramovitch, Gila Meir, Nava Nevo, Michael Holzinger, Ahuva Itin, Eli Keshet, and Michal Neeman
The maturity-onset diabetes of the young (MODY1) 13209-13214 transcription factor HNF4a regulates expression of genes required for glucose transport and metabolism
Markus Stoffel and Stephen A. Duncan
A mammalian model for Laron syndrome produced 13215-13220 by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)
Yihua Zhou, Bixiong C. Xu, Hiralal G. Maheshwari, Li He, Michael Reed, Maria Lozykowski, Shigeru Okada, Lori Cataldo, Karen Coschigamo, Thomas E. Wagner, Gerhard Baumann, and John J. Kopchick
Altered phosphorylation and intracellular distribution 13221-13226 of a (CUG), triplet repeat RNA-binding protein in patients with myotonic dystrophy and in myotonin protein kinase knockout mice
Robert Roberts, Nikolaj A. Timchenko, Jill W. Miller, Sita Reddy, C. Thomas Caskey, Maurice S. Swanson, and Lubov T. Timchenko
An epidemic of tuberculosis with a high rate of 13227-13232 tuberculin anergy among a population previously unexposed to tuberculosis, the Yanomami Indians of the Brazilian Amazon
Alexandra 0. Sousa, Julia I. Salem, Francis K. Lee, Maria C. Vercosa, Philippe Cruaud, Barry R. Bloom, Philippe H. Lagrange, and Hugo L. David
Overexpressed human CD44s promotes lung 13233-13238 colonization during micrometastasis of murine fibrosarcoma cells: Facilitated retention in the lung vasculature
Priit Kogerman, Man-Sun Sy, and Lloyd A. Culp
Murine hematopoietic reconstitution after tagging and 13239-13244 selection of retrovirally transduced bone marrow cells
B. Garcia-Hernandez, A. Castellanos, A. L6pez, A. Orfao, and I. Sanchez-Garcia
x
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 20:56:30 PMAll use subject to JSTOR Terms and Conditions
Use of model plant hosts to identify Pseudomonas 13245-13250 aeruginosa virulence factors
Laurence G. Rahme, Man-Wah Tan, Long Le, Sandy M. Wong, Ronald G. Tompkins, Stephen B. Calderwood, and Frederick M. Ausubel
Inactivation of the a C protein antigen gene, bca, by 13251-13256 a novel shuttle/suicide vector results in attenuation of virulence and immunity in group B Streptococcus
Jing Li, Dennis L. Kasper, Frederick M. Ausubel, Bernard Rosner, and James L. Michel
CooB plays a chaperone-like role for the proteins 13257-13261 involved in formation of CS1 pili of enterotoxigenic Escherichia coli
Karl Voegele, Harry Sakellaris, and June R. Scott
NEUROBIOLOGY
Electrophysiological studies on rat dorsal root 13262-13266 ganglion neurons after peripheral axotomy: Changes in responses to neuropeptides
Zhi-Qing David Xu, Xu Zhang, Sten Grillner, and Tomas Hokfelt
Marked decrease of neuropeptide Y Y2 receptor 13267-13272 binding sites in the hippocampus in murine prion disease
Margarita Diez, Jari Koistinaho, Stephen J. Dearmond, Darlene Groth, Stanley B. Prusiner, and Tomas Hokfelt
The synthesis of ATP by glycolytic enzymes in the 13273-13278 postsynaptic density and the effect of endogenously generated nitric oxide
Kuo Wu, Chiye Aoki, Alice Elste, Adrienne A. Rogalski-Wilk, and Philip Siekevitz
Neurotrophin release by neurotrophins: Implications 13279-13286 for activity-dependent neuronal plasticity
Marco Canossa, Oliver Griesbeck, Benedikt Berninger, Gabriele Campana, Roland Kolbeck, and Hans Thoenen
Two amyloid precursor protein transgenic mouse 13287-13292 models with Alzheimer disease-like pathology
Christine Sturchler-Pierrat, Dorothee Abramowski, Mairead Duke, Karl-Heinz Wiederhold, Claudia Mistl, Sabin Rothacher, Birgit Ledermann, Kurt Burki, Peter Frey, Paolo A. Paganetti, Caroline Waridel, Michael E. Calhoun, Mathias Jucker, Alphonse Probst, Matthias Staufenbiel, and Bernd Sommer
A hierarchical neuronal network for planning behavior 13293-13298 Stanislas Dehaene and Jean-Pierre Changeux
Role of intrinsic synaptic circuitry in collicular 13299-13304 sensorimotor integration
Psyche H. Lee, Matthew C. Helms, George J. Augustine, and William C. Hall
A homeodomain gene Ptx3 has highly restricted brain 13305-13310 expression in mesencephali Cc dopaminergic neurons
Marten P. Smidt, Hermien S. A. van Schaick, Christian Lanctot, Jacques J. Tremblay, Joke J. Cox, Arno A. M. van der Kleij, Gerrit Wolterink, Jacques Drouin, and J. Peter H. Burbach
Disruption of the ml receptor gene ablates 13311-13316 muscarinic receptor-dependent M current regulation and seizure activity in mice
Susan E. Hamilton, Michael D. Loose, Ming Qi, Allan I. Levey, Bertil Hille, G. Stanley McKnight, Rejean L. Idzerda, and Neil M. Nathanson
PHYSIOLOGY
Gi regulation of secretory vesicle swelling examined 13317-13322 by atomic force microscopy
Bhanu P. Jena, Stefan W. Schneider, John P. Geibel, Paul Webster, Hans Oberleithner, and Kumudesh C. Sritharan
Molecular mechanism of use-dependent calcium 13323-13328 channel block by phenylalkylamines: Role of inactivation
Steffen Hering, Stefan Aczel, Richard L. Kraus, Stanislav Berjukow, Jorg Striessnig, and Eugen N. Timin
Basolateral membrane targeting of a renal-epithelial 13329-13334 inwardly rectifying potassium channel from the cortical collecting duct, CCD-IRK3, in MDCK cells
Sophie Le Maout, Manuel Brejon, Olav Olsen, Jean Merot, and Paul A. Welling
Killing K Channels with TEA+ 13335-13338 Kamran Khodakhah, Alexey Melishchuk, and Clay M. Armstrong
Australian lungfish neurohypophysial hormone genes 13339-13344 encode vasotocin and [Phe2]mesotocin precursors homologous to tetrapod-type precursors
Susumu Hyodo, Susumu Ishii, and Jean M. P. Joss
PLANT BIOLOGY
A deletion in an indole synthase gene is responsible 13345-13350 for the DIMBOA-deficient phenotype of bxbx maize
Denise Melanson, Mary-Dell Chilton, David Masters-Moore, and W. Scott Chilton
ATPases and phosphate exchange activities in 13351-13356 magnesium chelatase subunits of Rhodobacter sphaeroides
Mats Hansson and C. Gamini Kannangara
Phytosulfokine-a, a sulfated pentapeptide, stimulates 13357-13362 the proliferation of rice cells by means of specific high- and low-affinity binding sites
Yoshikatsu Matsubayashi, Leiko Takagi, and Youji Sakagami
PSYCHOLOGY
Brain activity in visual cortex predicts individual 13363-13366 differences in reading performance
Jonathan B. Demb, Geoffrey M. Boynton, and David J. Heeger
Social Sciences
ANTHROPOLOGY
Appendicular robusticity and the paleobiology of 13367-13373 modern human emergence
E r ik Trinkaus
xi
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 20:56:30 PMAll use subject to JSTOR Terms and Conditions
El Institutional $615 El Individual $150 [1 Postdoctoral $125 C1 Student $ 90
ELSEWHERE (Surface Mail)
C Institutional $715 O Individual $250 [ Postdoctoral $225 LI Student $190
Expedited Delivery Rates are available on request. Individual, Student, and Postdoctoral subscriptions are for personal use only and are not to be used in any library. To qualify for the student or postdoctoral rate, your order must be accompanied by a letter from your advisor or supervisor, on institutional letterhead, stating that you are enrolled in a program of study leading to a degree or are within 4 years of receiving your doctorate. DC and Florida Subscribers: Add appropriate Sales Tax or provide evidence of tax exemption status. All subscriptions paid at the individual rate are taxable. All Subscribers in Canada add 7% GST (Registration Number R-133130880). Subscribers in Japan: Send orders to USACO Corporation, 13-12, Shimbashi, 1-Chome, Minato-ku, Tokyo 105 Japan.
Make remittance payable to the National Academy of Sciences. Foreign remittance must be by draft on a U.S. Bank or by International Money Order. Student and Postdoctoral subscriptions must be paid by personal check, money order, or credit card.
Credit Card Order: D MasterCard C1 VISA O American Express Amount $
Account Number Expiration Date_
Name of Account Holder Telephone or Fax # (please print or type)
Authorized Signature E-Mail
Shipping Information: (please type) Name Address
Send Credit Card orders and Correspondence to: Send Orders with Check or Money Order to: Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences 2101 Constitution Avenue, NW P.O. Box 631008 Washington, D.C. 20418 USA Baltimore, MD 21263-1008 USA
If you have any questions, you may contact us at 202/625-4725 (Telephone) or 202/625-4747 (Fax).
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 20:56:30 PMAll use subject to JSTOR Terms and Conditions
