Front Matter Source: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, No. 5 (Mar. 3, 1998), pp. i-xii Published by: National Academy of Sciences Stable URL: http://www.jstor.org/stable/43979 . Accessed: 05/05/2014 20:56 Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at . http://www.jstor.org/page/info/about/policies/terms.jsp . JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact [email protected]. . National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access to Proceedings of the National Academy of Sciences of the United States of America. http://www.jstor.org This content downloaded from 130.132.123.28 on Mon, 5 May 2014 20:56:53 PM All use subject to JSTOR Terms and Conditions
Transcript
Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 95, No. 5 (Mar. 3, 1998), pp. i-xiiPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/43979 .
Accessed: 05/05/2014 20:56
Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at .http://www.jstor.org/page/info/about/policies/terms.jsp
.JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range ofcontent in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new formsof scholarship. For more information about JSTOR, please contact [email protected].
.
National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access toProceedings of the National Academy of Sciences of the United States of America.
http://www.jstor.org
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NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Officers BRUCE ALBERTS, President of the JACK HALPERN, Vice President Academy PETER H. RAVEN, Home Secretary
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Editorial Board of the Proceedings
MAY R. BERENBAUM PETER J. BICKEL WILLIAM CATTERALL ANTHONY CERAMI PIERRE CHAMBON MARSHALL H. COHEN STANLEY N. COHEN DAVID R. DAVIES HERMAN N. EISEN RAYMOND L. ERIKSON ANTHONY S. FAUCI NINA FEDOROFF
CHARLES FEFFERMAN WALTER M. FITCH JOSEPH L. GOLDSTEIN CAROL A. GROSS JACK HALPERN BERTIL HILLE PIERRE C. HOHENBERG H. ROBERT HORVITZ ALFRED G. KNUDSON ROGER KORNBERG ROBERT LANGER HARVEY F. LODISH
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (ISSN-0027-8424) is published biweekly by THE NATIONAL ACADEMY OF SCIENCES. Correspondence: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, NW, Washington, DC 20418 USA (via U.S. postal service) or 1055 Thomas Jefferson Street, NW, Suite FO2013, Washington, DC 20007 USA (via courier or express mail). E-mail: [email protected]. Information for Authors: See pp. xvi-xviii (of this issue) or http://www.pnas.org. Copyright: Volumes 90-95, copyright (? 1993-1998 by THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, all rights reserved; Volumes 1-89, copyright as a collective work only [author(s) retains copyright to individual articles]. Requests for Permission: Address requests to reproduce material published in Volumes 1-89 to the original author(s); address other requests to the Permissions Office of the PROCEEDINGS, 2101 Constitution Avenue, NW, Washington, DC 20418 USA, FAX 202-625-4749. Please cite the exact material to be reprinted and state specifically where it will be used. Photocopies: The journal is registered with the Copyright Clearance Center, 222 Rosewood Drive, Danvers, MA 01923 USA, FAX 978-750-4470. Authorization to photocopy items for the internal or personal use of specific clients is granted by THE NATIONAL ACADEMY OF SCIENCES provided that the copier pays to the Center the fee stated in the code on the first page of each article. Microforms: Contact University Microfilms Inc., P.O. Box 1346, Ann Arbor, MI 48106-1346 USA. This journal is printed on acid-free paper effective with Volume 84, Issue 1. Subscriptions: Address subscription correspondence to the Circulation Office of the PROCEEDINGS, 2101 Constitution Avenue, NW, Washington, DC 20418 USA. Subscriptions are entered on a calendar-year basis only. The 1998 subscription rates for print only/online only/print plus online are as follows-in the U.S.: student, $90/$50/$110; postdoctoral, $125/$50/$150; personal, $165/$100/$195; institutional, $685/$615/$820-elsewhere (print by surface mail): student, $190/$50/$210; postdoctoral, $225/ $50/$250; personal, $265/$100/$295; institutional, $785/$615/$920-elsewhere by expedited delivery at a surcharge of $320. Air mail rates available on request. Exclusive Agent for Subscribers in Japan: USACO Corporation, 13-12, Shimbashi, 1-Chome, Minato-ku, Tokyo 105 Japan. Change ofAddress: Notify the Circulation Office 6 weeks in advance and list the old and new addresses. The Academy is not responsible for nonreceipt of issues because of an improper address, unless a change of address is on file. Claims: Requests for replacement copies will not be honored more than 60 days after the issue date for domestic subscribers and not more than 90 days after the issue date for foreign subscribers. Claims will not be honored for more than 2 issues per calendar year for the same subscriber. Single Copies: $30 per issue in the U.S., $40 elsewhere. Canadian GST: Registration Number R-133130880. Advertising: Contact FASEB AdNet, 9650 Rockville Pike, Bethesda, MD 20814-3998 USA. Phone 800-43-FASEB X7103 or 301-530-7103, FAX 301-571-0683. Postmaster: Send address changes to PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, NW, Washington, DC 20418 USA. Periodicals postage paid at Washington, DC, and additional mailing offices. PRINTED IN THE USA PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES is also available online at http://www.pnas.org. Cover photograph: Hildreth Meiere's emblematic figure depicting Botany with peas and sunflowers: One of eight radial panels on the dome of the Great Hall at the National Academy of Sciences.
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Papers from a National Academy of Sciences Colloquium on Protecting Our Food Supply: The Value of Plant Genome Initiatives
Plant genomics and our food supply: An introduction 1969-1970 Ronald L. Phillips and Michael Freeling
Comparative genetics in the grasses 1971-1974 Michael D. Gale and Katrien M. Devos
Grass genomes 1975-1978 Jeffrey L. Bennetzen, Phillip SanMiguel, Mingsheng Chen, Alexander Tikhonov, Michael Francki, and Zoya Avramova
Down-regulation of RFL, the FLO/LFY homolog of 1979-1982 rice, accompanied with panicle branch initiation
Junko Kyozuka, Saeko Konishi, Keisuke Nemoto, Takeshi Izawa, and Ko Shimamoto
Toward a plant genomics initiative: Thoughts on the 1983-1985 value of cross-species and cross-genera comparisons in the grasses
Susan McCouch
Plant genomics: More than food for thought 1986-1988 Steven P. Briggs
Assisting developing countries toward food 1989-1992 self-reliance
Robert W. Herdt
Toward a successful multinational crop plant 1993-1995 genome initiative
R. James Cook
Quantitative trait loci and metabolic pathways 1996-2000 M. D. McMullen, P. F. Byrne, M. E. Snook, B. R. Wiseman, E. A. Lee, N. W. Widstrom, and E. H. Coe
Genome projects and gene pools: New germplasm 2001-2004 for plant breeding?
Michael Lee
Relationships of cereal crops and other grasses 2005-2010 Elizabeth A. Kellogg
Plant genome values: How much do we know? 2011-2016 Michael D. Bennett
Importance of anchor genomes for any plant 2017-2020 genome project
Joachim Messing and Victor Llaca
Functional genomics: Probing plant gene function 2021-2026 and expression with transposons
Robert A. Martienssen
The rice genome project in Japan 2027-2028 Takuji Sasaki
iii
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Potentials of the National Corn Genome Initiative 2029-2032 E. H. Coe
Commentaries
Targeted disruption of the HFE gene 2033-2034 Ernest Beutler
Enzyme engineering reaches the boiling point 2035-2036 Frances H. Arnold
A base called J 2037-2038 Larry Simpson
Physical Sciences
PHYSICS
Optimal modulation of a Brownian ratchet and 2039-2043 enhanced sensitivity to a weak external force
Martin B. Tarlie and R. Dean Astumian
Biological Sciences
APPLIED BIOLOGICAL SCIENCES
Multiple evolutionary origins of the fungus causing 2044-2049 Panama disease of banana: Concordant evidence from nuclear and mitochondrial gene genealogies
Kerry O'Donnell, H. Corby Kistler, Elizabeth Cigelnik, and Randy C. Ploetz
BIOCHEMISTRY
Antagonism of glucocorticoid receptor transcriptional 2050-2055 activation by the c-Jun N-terminal kinase
Inez Rogatsky, Susan K. Logan, and Michael J. Garabedian
Engineering an enzyme to resist boiling 2056-2060 Bertus Van den Burg, Gert Vriend, Oene R. Veltman, Gerard Venema, and Vincent G. H. Eijsink
CREB-binding protein cooperates with 2061-2066 transcription factor GATA-1 and is required for erythroid differentiation
Gerd A. Blobel, Toshihiro Nakajima, Richard Eckner, Marc Montminy, and Stuart H. Orkin
A highly conserved lysine residue on the head 2067-2072 domain of type II keratins is essential for the attachment of keratin intermediate filaments to the cornified cell envelope through isopeptide crosslinking by transglutaminases
Eleonora Candi, Edit Tarcsa, John J. Digiovanna, John G. Compton, Peter M. Elias, Lyuben N. Marekov, and Peter M. Steinert
Inhibition of translation and bacterial growth 2073-2076 by peptide nucleic acid targeted to ribosomal RNA
Liam Good and Peter E. Nielsen
Domain requirements for the Dock adapter 2077-2082 protein in growth-cone signaling
Yong Rao and S. Lawrence Zipursky
Retrotransposon R1Bm endonuclease cleaves 2083-2088 the target sequence
Qinghua Feng, Gerald Schumann, and Jef D. Boeke
A cysteine-rich domain of the "mannose" receptor 2089-2093 mediates GalNAc-4-SO4 binding
Dorothy J. Fiete, Mary C. Beranek, and Jacques U. Baenziger
Codominant interference, antieffectors, and 2094-2099 multitarget drugs
Alexander Varshavsky
A family of transketolases that directs isoprenoid 2100-2104 biosynthesis via a mevalonate-independent pathway
B. Markus Lange, Mark R. Wildung, David McCaskill, and Rodney Croteau
Cloning and characterization of a gene from 2105-2110 Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of D-1-deoxyxylulose 5-phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis
Luisa Maria Lois, Narciso Campos, Surya Rosa Putra, Knut Danielsen, Michel Rohmer, and Albert Boronat
A method for assaying intestinal brush-border 2111-2116 sucrase in an intact intestinal preparation
Eric A. Lee, Stacey L. Weiss, Mandy Lam, Rosa Torres, and Jared Diamond
Evolutionary matches of enzyme and transporter 2117-2121 capacities to dietary substrate loads in the intestinal brush border
Stacey L. Weiss, Eric A. Lee, and Jared Diamond
CREB-binding protein in androgen 2122-2127 receptor-mediated signaling
Piia Aarnisalo, Jorma J. Palvimo, and Olli A. Janne
Peroxisomal D-hydroxyacyl-CoA dehydrogenase 2128-2133 deficiency: Resolution of the enzyme defect and its molecular basis in bifunctional protein deficiency
Elisabeth G. van Grunsven, Emanuel van Berkel, Lodewijk Ijlst, Peter Vreken, Johannis B. C. de Klerk, Jerzy Adamski, Hugh Lemonde, Peter T. Clayton, Dean A. Cuebas, and Ronald J. A. Wanders
Integration of the Tetrahymena group I 2134-2139 intron into bacterial rRNA by reverse splicing In vivo
Judibelle Roman and Sarah A. Woodson
v
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Reversible dissociation of coatomer: Functional 2140-2145 characterization of a ,(3/-coat protein subcomplex
Jochen Pavel, Cordula Harter, and Felix T. Wieland
A cofactor, TIP30, specifically enhances HIV-1 2146-2151 Tat-activated transcription
Hua Xiao, Yong Tao, Jack Greenblatt, and Robert G. Roeder
Sequence-specific ligation of DNA using 2152-2157 RecA protein
Lance J. Ferrin and R. Daniel Camerini-Otero
In vitro selection of a purine nucleotide-specific 2158-2162 hammerhead-like ribozyme
Narendra K. Vaish, Paul A. Heaton, Olga Fedorova, and Fritz Eckstein
SR proteins are sufficient for exon bridging across 2163-2168 an intron
Jeremy M. Stark, David P. Bazett-Jones, Manfred Herfort, and Mark B. Roth
Aggregation of the human high affinity 2169-2174 immunoglobulin G receptor (FcyRI) activates both tyrosine kinase and G protein-coupled phosphoinositide 3-kinase isoforms
Alirio J. Melendez, David J. Gillooly, Margaret M. Harnett, and Janet M. Allen
Accelerated reaction of nitric oxide with 02 within 2175-2179 the hydrophobic interior of biological membranes
Xiaoping Liu, Mark J. S. Miller, Mahesh S. Joshi, Douglas D. Thomas, and Jack R. Lancaster, Jr.
Isotope exchange studies on the Escherichia coli 2180-2185 selenophosphate synthetase mechanism
Heidi Walker, James A. Ferretti, and Thressa C. Stadtman
Changes in solvation during DNA binding and 2186-2191 cleavage are critical to altered specificity of the EcoRI endonuclease
Clifford R. Robinson and Stephen G. Sligar
A dynamic model for PC4 coactivator function in 2192-2197 RNA polymerase II transcription
Sohail Malik, Mohamed Guermah, and Robert G. Roeder
Daidzin and its antidipsotropic analogs inhibit 2198-2203 serotonin and dopamine metabolism in isolated mitochondria
Wing Ming Keung and Bert L. Vallee
Amine binding and oxidation at the catalytic site 2204-2209 for photosynthetic water oxidation
Anthony J. A. Ouellette, Lorraine B. Anderson, and Bridgette A. Barry
Evidence for distinct mechanisms of 2210-2215 transition state stabilization of GTPases by fluoride
Sylvie Vincent, Madeleine Brouns, Matthew J. Hart, and Jeffrey Settleman
Germacrene C synthase from Lycopersicon 2216-2221 esculentum cv. VFNT Cherry tomato: cDNA isolation, characterization, and bacterial expression of the multiple product sesquiterpene cyclase
Sheila M. Colby, John Crock, Barbara Dowdle-Rizzo, Peggy G. Lemaux, and Rodney Croteau
A serine cluster prevents recycling of the V2 2222-2226 vasopressin receptor
Giulio Innamorati, Hamid M. Sadeghi, Nathaniel T. Tran, and Mariel Birnbaumer
Brome mosaic virus RNA replication 2227-2232 protein la dramatically increases in vivo stability but not translation of viral genomic RNA3
Michael Janda and Paul Ahlquist
Cleaving DNA with DNA 2233-2237 Nir Carmi, Shameelah R. Balkhi, and Ronald R. Breaker
A poly(A) binding protein functions in 2238-2243 the chloroplast as a message-specific translation factor
Christopher B. Yohn, Amybeth Cohen, Avihai Danon, and Stephen P. Mayfield
Junction ribonuclease: An activity in Okazaki 2244-2249 fragment processing
Richard S. Murante, Leigh A. Henricksen, and Robert A. Bambara
Oxalp, an essential component of the N-tail protein 2250-2255 export machinery in mitochondria
Kai Hell, Johannes M. Herrmann, Elke Pratje, Walter Neupert, and Rosemary A. Stuart
Peter C. Simpson, David Roach, Adam T. Woolley, Todd Thorsen, Rick Johnston, George F. Sensabaugh, and Richard A. Mathies
Structure comparison of human glioma 2262-2266 pathogenesis-related protein GliPR and the plant pathogenesis-related protein P14a indicates a functional link between the human immune system and a plant defense system
T. Szyperski, C. Fernandez, C. Mumenthaler, and K. Wuthrich
Protein hydration in solution: Experimental 2267-2272 observation by x-ray and ncutron scattering
D. I. Svergun, S. Richard, M. H. J. Koch, Z. Sayers, S. Kuprin, and G. Zaccai
vi
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Evidence for the load-dependent mechanical 2273-2278 efficiency of individual myosin heads in skeletal muscle fibers activated by laser flash photolysis of caged calcium in the presence of a limited amount of ATP
Haruo Sugi, Hiroyuki Iwamoto, Tsuyoshi Akimoto, and Hiroko Ushitani
CELL BIOLOGY
Vesicles on strings: Morphological evidence for 2279-2283 processive transport within the Golgi stack
Lelio Orci, Alain Perrelet, and James E. Rothman
Stabilization and activation of p53 are regulated 2284-2289 independently by different phosphorylation events
Mikhail V. Chernov, Chilakamarti V. Ramana, Victor V. Adler, and George R. Stark
Human papillomavirus type 16 E6 and E7 2290-2295 oncogenes abrogate radiation-induced DNA damage responses in vivo through p53-dependent and p53-independent pathways
Shiyu Song, Gene A. Gulliver, and Paul F. Lambert
The yeast nascent polypeptide-associated 2296-2301 complex initiates protein targeting to mitochondria in vivo
Rebecca George, Travis Beddoe, Karina Landl, and Trevor Lithgow
BRCA1 regulates p53-dependent gene expression 2302-2306 Toru Ouchi, Alvaro N. A. Monteiro, Avery August, Stuart A. Aaronson, and Hidesaburo Hanafusa
Alterations in NF-KB function in transgenic 2307-2312 epithelial tissue demonstrate a growth inhibitory role for NF-KB
Cornelia S. Seitz, Qun Lin, Helen Deng, and Paul A. Khavari
Presence and phosphorylation of transcription 2313-2318 factors in developing dendrites
Peter Crino, Kamran Khodakhah, Kevin Becker, Stephen Ginsberg, Scott Hemby, and James Eberwine
Hsp7O accumulation in chondrocytic cells 2319-2324 exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation
K. Kaarniranta, M. Elo, R. Sironen, M. J. Lammi, M. B. Goldring, J. E. Eriksson, L. Sistonen, and H. J. Helminen
Differential regulation by estrogens of growth 2325-2330 and prolactin synthesis in pituitary cells suggests that only a small pool of estrogen receptors is required for growth
Tae-Yon Chun, David Gregg, Dipak K. Sarkar, and Jack Gorski
RNA-binding protein TIAR is essential for 233 1-2336 primordial germ cell development
Andreas R. P. Beck, Ira J. Miller, Paul Anderson, and Michel Streuli
Skeletal overgrowth in transgenic mice that 2337-2342 overexpress brain natriuretic peptide
The Ig mutator is dependent on the presence, 2396-2399 position, and orientation of the large intron enhancer
Juergen Bachl, Carina Olsson, Nishay Chitkara, and Matthias Wabl
Overexpression of the SUP45 gene encoding 2400-2405 a Sup35p-binding protein inhibits the induction of the de novo appearance of the [PSI'] prion
Irina L. Derkatch, Michael E. Bradley, and Susan W. Liebman
SHOT, a SHOX-related homeobox gene, is 2406-2411 implicated in craniofacial, brain, heart, and limb development
Rudiger J. Blaschke, A. Paula Monaghan, Simone Schiller, Birgit Schechinger, Ercole Rao, Hesed Padilla-Nash, Thomas Ried, and Gudrun A. Rappold
Targeted deletion of Smad4 shows it is required 2412-2416 for transforming growth factor ,3 and activin signaling in colorectal cancer cells
Shibin Zhou, Phillip Buckhaults, Leigh Zawel, Fred Bunz, Greg Riggins, Jia Le Dai, Scott E. Kern, Kenneth W. Kinzler, and Bert Vogelstein
An additional role for the F-box motif: Gene 2417-2422 regulation within the Neurospora crassa sulfur control network
Anuj Kumar and John V. Paietta
Both allelic variation and expression of nuclear 2423-2428 and cytoplasmic transcripts of Hsr-omega are closely associated with thermal phenotype in Drosophila
Stephen W. McKechnie, Michael M. Halford, Gawain McColl, and Ary A. Hoffmann
Cdkn2a, the cyclin-dependent kinase inhibitor 2429-2434 encoding p16INK4a and pI9ARF, is a candidate for the plasmacytoma susceptibility locus, Pctrl
Shuling Zhang, Edward S. Ramsay, and Beverly A. Mock
IMMUNOLOGY
Induction of transporter associated with antigen 2435-2440 processing by interferon y confers endothelial cell cytoprotection against natural killer-mediated lysis
Oran Ayalon, Eric A. Hughes, Peter Cresswell, Jennifer Lee, Lynn O'Donnell, Ruggero Pardi, and Jeffrey R. Bender
Prevention of Th2-mediated murine allergic 2441-2445 airways disease by soluble antigen administration in the neonate
Simon P. Hogan, Paul S. Foster, Brett Charlton, and Robyn M. Slattery
The paired Ig-like receptor PIR-B is an inhibitory 2446-2451 receptor that recruits the protein-tyrosine phosphatase SHP-1
Mathieu Blery, Hiromi Kubagawa, Ching-Cheng Chen, Frederic Vely, Max D. Cooper, and Eric Vivier
Human T cell lymphotropic virus type I Tax protein 2452-2457 trans-activates interleukin 15 gene transcription through an NF-KB site
Nazli Azimi, Keith Brown, Richard N. Bamford, Yutaka Tagaya, Ulrich Siebenlist, and Thomas A. Waldmann
CD81 on B cells promotes interleukin 4 secretion 2458-2462 and antibody production during T helper type 2 immune responses
Holden T. Maecker, Myoung-Sool Do, and Shoshana Levy
Frequent occurrence of deletions and duplications 2463-2468 during somatic hypermutation: Implications for oncogene translocations and heavy chain disease
Tina Goossens, Ulf Klein, and Ralf Kuppers
The role of inducible nitric oxide synthase in the 2469-2474 host response to Coxsackievirus myocarditis
Carlos Zaragoza, Christopher Ocampo, Marta Saura, Michelle Leppo, Xiao-Qing Wei, Richard Quick, Salvador Moncada, Foo Y. Liew, and Charles J. Lowenstein
Gene therapy with a single chain interleukin 12 2475-2480 fusion protein induces T cell-dependent protective immunity in a syngeneic model of murine neuroblastoma
Holger N. Lode, Torsten Dreier, Rong Xiang, Nissi M. Varki, Angray S. Kang, and Ralph A. Reisfeld
Immunization against rabies with plant-derived 2481-2485 antigen
Anna Modelska, Bernard Dietzschold, N. Sleysh, Zhen Fang Fu, Klaudia Steplewski, D. Craig Hooper, Hilary Koprowski, and Vidadi Yusibov
Two distinct pathways of positive selection 2486-2491 for thymocytes
Koichi Akashi, Motonari Kondo, and Irving L. Weissman
MEDICAL SCIENCES
HFE gene knockout produces mouse model of 2492-2497 hereditary hemochromatosis
Xiao Yan Zhou, Shunji Tomatsu, Robert E. Fleming, Seppo Parkkila, Abdul Waheed, Jinxing Jiang, Ying Fei, Elizabeth M. Brunt, David A. Ruddy, Cynthia E. Prass, Randall C. Schatzman, Rosemary O'Neill, Robert S. Britton, Bruce R. Bacon, and William S. Sly
Fatty acid-induced ,B cell apoptosis: A link between 2498-2502 obesity and diabetes
Michio Shimabukuro, Yan-Ting Zhou, Moshe Levi, and Roger H. Unger
Mice with type 2 and 3 Gaucher disease point 2503-2508 mutations generated by a single insertion mutagenesis procedure (SIMP)
Yujing Liu, Kinuko Suzuki, Jennifer D. Reed, Alexander Grinberg, Heiner Westphal, Alexander Hoffmann, Thomas Doring, Konrad Sandhoff, and Richard L. Proia
viii
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A simplified system for generating 2509-2514 recombinant adenoviruses
Tong-Chuan He, Shibin Zhou, Luis T. da Costa, Jian Yu, Kenneth W. Kinzler, and Bert Vogelstein
Modulation of GTPase activity of G proteins by 2515-2519 fluid shear stress and phospholipid composition
Sivaramaprasad Gudi, John P. Nolan, and John A. Frangos
Vaccination with an attenuated Creutzfeldt-Jakob 2520-2525 disease strain prevents expression of a virulent agent
Laura Manuelidis
Ectopic expression of N-acetylglucosaminyltransferase 2526-2530 III in transgenic hepatocytes disrupts apolipoprotein B secretion and induces aberrant cellular morphology with lipid storage
Yoshito Ihara, Masafumi Yoshimura, Eiji Miyoshi, Atsushi Nishikawa, Ahmed S. Sultan, Satoru Toyosawa, Akio Ohnishi, Misao Suzuki, Ken-ichi Yamamura, Naokuni Ijuhin, and Naoyuki Taniguchi
Model studies directed toward the application of 2531-2534 boron neutron capture therapy to rheumatoid arthritis: Boron delivery by liposomes in rat collagen-induced arthritis
Rachel A. Watson-Clark, Mona Lisa Banquerigo, Kenneth Shelly, M. Frederick Hawthorne, and Ernest Brahn
Identification of a substrate-targeting domain in 2535-2540 cyclin E necessary for phosphorylation of the retinoblastoma protein
Beth L. Kelly, Karen G. Wolfe, and James M. Roberts
Synchronicity of frequently sampled, 24-h 2541-2546 concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women
Julio Licinio, Andr6 B. Negrao, Christos Mantzoros, Virginia Kaklamani, Ma-Li Wong, Peter B. Bongiorno, Abeda Mulla, Laura Cearnal, Johannes D. Veldhuis, Jeffrey S. Flier, Samuel M. McCann, and Philip W. Gold
Natriuretic peptide receptor 1 expression 2547-2551 influences blood pressures of mice in a dose-dependent manner
Paula M. Oliver, Simon W. M. John, Kit E. Purdy, Ron Kim, Nobuyo Maeda, Michael F. Goy, and Oliver Smithies
Angiotensin-converting enzyme and male fertility 2552-2557 John R. Hagaman, Jeffrey S. Moyer, Eric S. Bachman, Mathilde Sibony, Patricia L. Magyar, Jeffrey E. Welch, Oliver Smithies, John H. Krege, and Deborah A. O'Brien
Acceleration of amyloid protein A amyloidosis by 2558-2563 amylo id -like synt he tic fibril s
Katarzyna Johan, Gunilla Westermark, Ulla Engstrom, Asa Gustavsson, Per Hultman, and Per Westermark
MICROBIOLOGY
Identification in a pseudoknot of a U-G motif 2564-2567 essential for the regulation of the expression of ribosomal protein S15
Lionel B6nard, Nathalie Mathy, Marianne Grunberg-Manago, Bernard Ehresmann, Chantal Ehresmann, and Claude Portier
The chemotaxis system, but not chemotaxis, is 2568-2573 essential for swarming motility in Escherichia coli
Mark Burkart, Adam Toguchi, and Rasika M. Harshey
A substrate of the centisome 63 type III protein 2574-2579 secretion system of Salmonella typhimurium is encoded by a cryptic bacteriophage
Wolf-Dietrich Hardt, Henning Urlaub, and Jorge E. Galan
Receptor-triggered membrane association of a 2580-2585 model retroviral glycoprotein
Rachel L. Damico, Joanne Crane, and Paul Bates
NEUROBIOLOGY
A splicing variant of a death domain protein 2586-2591 that is regulated by a mitogen-activated kinase is a substrate for c-Jun N-terminal kinase in the human central nervous system
Yan Zhang, Li Zhou, and Carol A. Miller
Neural cell adhesion molecule (N-CAM) 2592-2596 domains and intracellular signaling pathways involved in the inhibition of astrocyte proliferation
Leslie A. Krushel, Ming-Hong Tai, Bruce A. Cunningham, Gerald M. Edelman, and Kathryn L. Crossin
Allosteric modulation of AMPA-type 2597-2602 glutamate receptors increases activity of the promoter for the neural cell adhesion molecule, N-CAM
Brent D. Holst, Peter W. Vanderklish, Leslie A. Krushel, Wei Zhou, Ronald B. Langdon, John R. McWhirter, Gerald M. Edelman, and Kathryn L. Crossin
Bcl-xL protects adult septal cholinergic neurons 2603-2608 from axotomized cell death
U. Bl6mer, T. Kafri, L. Randolph-Moore, I. M. Verma, and F. H. Gage
Overrepresentation of horizontal and vertical 2609-2614 orientation preferences in developing ferret area 17
Barbara Chapman and Tobias Bonhoeffer
Genomic sequences of aldolase C (Zebrin II) direct 2615-2620 lacZ expression exclusively in non-neuronal cells of transgenic mice
Ernst U. Walther, Martin Dichgans, Stephen M. Maricich, Rita R. Romito, Fei Yang, Suzan Dziennis, Saul Zackson, Richard Hawkes, and Karl Herrup
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Unequal representation of cardinal and oblique 2621-2623 contours in ferret visual cortex
David M. Coppola, Leonard E. White, David Fitzpatrick, and Dale Purves
Effects of feline immunodeficiency virus on astrocyte 2624-2629 glutamate uptake: Implications for lentivirus-induced central nervous system diseases
N. Yu, J. N. Billaud, and T. R. Phillips
Hypoalgesia in mice with a targeted deletion of the 2630-2635 tachykinin 1 gene
Andreas Zimmer, Anne M. Zimmer, Judith Baffi, Ted Usdin, Kay Reynolds, Monika Konig, Mikl6s Palkovits, and Eva Mezey
Functional disruption in the organization of the 2636-2641 brain for reading in dyslexia
Sally E. Shaywitz, Bennett A. Shaywitz, Kenneth R. Pugh, Robert K. Fulbright, R. Todd Constable, W. Einar Mencl, Donald P. Shankweiler, Alvin M. Liberman, Pawel Skudlarski, Jack M. Fletcher, Leonard Katz, Karen E. Marchione, Cheryl Lacadie, Christopher Gatenby, and John C. Gore
Chronic lithium treatment robustly protects 2642-2647 neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx
Shigeyuki Nonaka, Christopher J. Hough, and De-Maw Chuang
PHARMACOLOGY
Expression of Q227L-Gas in MCF-7 human breast 2648-2652 cancer cells inhibits tumorigenesis
Jianghao Chen, Jeffry A. Bander, Tara Ann Santore, Yibang Chen, Prahlad T. Ram, Martine J. Smit, and Ravi Iyengar
Point mutations in segment I-S6 render 2653-2658 voltage-gated Na+ channels resistant to batrachotoxin
Sho-Ya Wang and Ging Kuo Wang
Peroxynitrite decomposition catalysts: Therapeutics 2659-2663 for peroxynitrite-mediated pathology
Daniela Salvemini, Zhi-Qiang Wang, Michael K. Stern, Mark G. Currie, and Thomas P. Misko
PHYSIOLOGY
Prevention of renovascular and cardiac 2664-2669 pathophysiological changes in hypertension by angiotensin II type 1 receptor antisense gene therapy
Jeffrey R. Martens, Phyllis Y. Reaves, Di Lu, Michael J. Katovich, Kathleen H. Berecek, Sanford P. Bishop, Mohan K. Raizada, and Craig H. Gelband
New findings of the correlation between 2670-2673 acupoints and corresponding brain cortices using functional MRI
Z. H. Cho, S. C. Chung, J. P. Jones, J. B. Park, H. J. Park, H. J. Lee, E. K. Wong, and B. I. Min
Chloride channel and chloride conductance regulator 2674-2679 domains of CFTR, the cystic fibrosis transmembrane conductance regulator
Erik M. Schwiebert, Marcelo M. Morales, Sreenivas Devidas, Marie E. Egan, and William B. Guggino
Fatty acids suppress voltage-gated Na+ currents 2680-2685 in HEK293t cells transfected with the a-subunit of the human cardiac Na+ channel
Yong-Fu Xiao, Sterling N. Wright, Ging Kuo Wang, James P. Morgan, and Alexander Leaf
PLANT BIOLOGY
Enhancement of blue-light sensitivity of 2686-2690 Arabidopsis seedlings by a blue light receptor cryptochrome 2
Chentao Lin, Hongyun Yang, Hongwei Guo, Todd Mockler, Jeff Chen, and Anthony R. Cashmore
Response regulators implicated in His-to-Asp 2691-2696 phosphotransfer signaling in Arabidopsis
Aya Imamura, Naoto Hanaki, Hiroyuki Umeda, Ayako Nakamura, Tomomi Suzuki, Chiharu Ueguchi, and Takeshi Mizuno
Abscisic acid signal transduction in the barley 2697-2702 aleurone is mediated by phospholipase D activity
Sian Ritchie and Simon Gilroy
PSYCHOLOGY
Neural correlates of the episodic encoding of 2703-2708 pictures and words
Cheryl L. Grady, Anthony R. McIntosh, M. Natasha Rajah, and Fergus I. M. Craik
Comparison of the auditory systems of 2709-2713 heterosexuals and homosexuals: Click-evoked otoacoustic emissions
Dennis McFadden and Edward G. Pasanen
CORRECTIONS
BIOCHEMISTRY Characterization of recombinant phytochrome from 2714 the cyanobacterium Synechocystis
Tilman Lamparter, Franz Mittmann, Wolfgang Gartner, Thomas Bo3rner, Elmar Hartmann, and Jon Hughes
NEUROBIOLOGY f3 subunits influence the biophysical and 2714 pharmacological differences between P- and 0-type calcium currents expressed in a mammalian cell line
Herman Moreno, Bernado Rudy, and Rodolfo Llinas
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