Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 95, No. 10 (May 12, 1998), pp. i-xPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/45097 .

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OF THE

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PROCEEDINGS OF THE

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,r ,OF?g

4'J

PROCGELDINGS OF THE

NATIONAL ACADEMY OF SCIENCES

OF THE UNITED STATES OF AMERICA

May 12, 1998 Volume 95, Number 10 pp. 5421-5842

Table of Contents

Commentary

Artificial death switches: Induction of apoptosis by 5421-5422 chemically induced caspase multimerization

Hermann Steller

Papers presented at the Symposium "A Song Among the Ruins: 50 Years of Japanese/Academy Cooperative Studies of Atomic Bomb Survivors"

An Introduction to "A Song Among the Ruins" 5423 John E. Dowling

Greetings: 50 years of Atomic Bomb Casualty 5424-5425 Commission-Radiation Effects Research Foundation studies

Itsuzo Shigematsu

The Atomic Bomb Casualty Commission in retrospect 5426-5431 Frank W. Putnam

Genetic studies at the Atomic Bomb Casualty 5432-5436 Commission-Radiation Effects Research Foundation: 1946-1997

James V. Neel

The somatic effects of exposure to atomic radiation: 5437-5441 The Japanese experience, 1947-1997

William J. Schull

Inaugural Article

Locomotion: Dealing with friction 5448-5455 V. Radhakrishnan

Physical Sciences

CHEMISTRY

Trends in odor intensity for human and electronic 5442-5447 noses: Relative roles of odorant vapor pressure vs. molecularly specific odorant binding

Brett J. Doleman, Erik J. Severin, and Nathan S. Lewis

ENGINEERING

Locomotion: Dealing with friction 5448-5455 V. Radhakrishnan

STATISTICS

Application of a time-dependent coalescence process 5456-5461 for inferring the history of population size changes from DNA sequence data

Andrzej Polanski, Marek Kimmel, and Ranajit Chakraborty

v

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Diagram of the categories of genes on the Atlas Human Cancer Array. A complete gene list is available at wwwv.clontech.com/clontech/Atlasform.htrnl.

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Contents

Biological Sciences

APPLIED BIOLOGICAL SCIENCES

DNA ligands that bind tightly and selectively 5462-5467 to cellobiose

Qing Yang, Irwin J. Goldstein, Houng-Yau Mei, and David R. Engelke

BIOCHEMISTRY

The chromatin unfolding domain of chromosomal 5468-5473 protein HMG-14 targets the N-terminal tail of histone H3 in nucleosomes

Lothar Trieschmann, Brian Martin, and Michael Bustin

The basic-helix-loop-helix-PAS orphan MOP3 forms 5474-5479 transcriptionally active complexes with circadian and hypoxia factors

John B. Hogenesch, Yi-Zhong Gu, Sanjay Jain, and Christopher A. Bradfield

Association-induced folding of globular proteins 5480-5483 Vladimir N. Uversky, Daniel J. Segel, Sebastian Doniach, and Anthony L. Fink

Genetic, biochemical, and crystallographic 5484-5489 characterization of Fhit-substrate complexes as the active signaling form of Fhit

Helen C. Pace, Preston N. Garrison, Angela K. Robinson, Larry D. Barnes, Alexandra Draganescu, Angelika R6sler, G. Michael Blackburn, Zurab Siprashvili, Carlo M. Croce, Kay Huebner, and Charles Brenner

The role of charged residues mediating low affinity 5490-5494 protein-protein recognition at the cell surface by CD2

Simon J. Davis, Elizabeth A. Davies, Michael G. Tucknott, E. Yvonne Jones, and P. Anton van der Merwe

Snapshot of a phosphorylated substrate intermediate 5495-5500 by kinetic crystallography

Helena Kack, Katharine J. Gibson, Ylva Lindqvist, and Gunter Schneider

Crystal structure of the channel-forming polypeptide 5501-5504 antiamoebin in a membrane-mimetic environment

Isabella L. Karle, Mary Ann Perozzo, Vinod K. Mishra, and Padmanabhan Balaram

In vitro site-specific integration of bacteriophage 5505-5510 DNA catalyzed by a recombinase of the resolvase/invertase family

Helena M. Thorpe and Margaret C. M. Smith

Directed evolution of an aspartate aminotransferase 5511-5515 with new substrate specificities

Takato Yano, Shinya Oue, and Hiroyuki Kagamiyama

PD-loop: A complex of duplex DNA with 5516-5520 an oligonucleotide

Nikolay 0. Bukanov, Vadim V. Demidov, Peter B. Nielsen, and Maxim D. Frank-Kamenetskii

Persistence of an alternate chromatin structure at 5521-5526 silenced loci in the absence of silencers

Tzu-Hao Cheng, Yao-Cheng Li, and Marc R. Gartenberg

From estrogen to androgen receptor: A new pathway 5527-5532 for sex hormones in prostate

Shuyuan Yeh, Hiroshi Miyamoto, Hiroki Shima, and Chawnshang Chang

Evidence of high levels of methylglyoxal in cultured 5533-5538 Chinese hamster ovary cells

Frank W. R. Chaplen, William E. Fahl, and Douglas C. Cameron

Physical interaction between retinoic acid receptor 5539-5544 and the oncoprotein Myb inhibits retinoic acid-dependent transactivation

Edith Pfitzner, Jutta Kirfel, Peter Becker, Andreas Rolke, and Roland Schiile

BIOPHYSICS

On the thermodynamic hypothesis of protein folding 5545-5549 Sridhar Govindarajan and Richard A. Goldstein

Conduction-band-edge ionization thresholds of DNA 5550-5555 components in aqueous solution

Harshica Fernando, George A. Papadantonakis, Nancy S. Kim, and Pierre R. LeBreton

CELL BIOLOGY

Signal-dependent translation of a regulatory protein, 5556-5561 Bcl-3, in activated human platelets

Andrew S. Weyrich, Dan A. Dixon, Ravinder Pabla, Mark R. Elstad, Thomas M. McIntyre, Stephen M. Prescott, and Guy A. Zimmerman

Alzheimer's-specific effects of soluble f-amyloid on 5562-5567 protein kinase C-a and -_y degradation in human fibroblasts

Antonella Favit, Maurizio Grimaldi, Thomas J. Nelson, and Daniel L. Alkon

STAT3 complements defects in an interferon-resistant 5568-5572 cell line: Evidence for an essential role for STAT3 in interferon signaling and biological activities

Chuan-He Yang, Aruna Murti, and Lawrence M. Pfeffer

Dopamine-induced recruitment of dopamine Dl 5573-5578 receptors to the plasma membrane

Hjalmar Brismar, Mohammad Asghar, Robert M. Carey, Paul Greengard, and Anita Aperia

Angiostatin induces endothelial cell apoptosis and 5579-5583 activation of focal adhesion kinase independently of the integrin-binding motif RGD

Lena Claesson-Welsh, Michael Welsh, Nobuyuki Ito, Bela Anand-Apte, Shay Soker, Bruce Zetter, Michael O'Reilly, and Judah Folkman

Plasma membrane localization is required for RGS4 5584-5589 function in Saccharomyces cerevisiae

Sreesha P. Srinivasa, Leah S. Bernstein, Kendall J. Blumer, and Maurine E. Linder

vii

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Contents

Signal transduction and activator of transcription 5590-5594 (STAT) protein-dependent activation of angiotensinogen promoter: A cellular signal for hypertrophy in cardiac muscle

Eduardo Mascareno, Manya Dhar, and M. A. Q. Siddiqui

Fas-induced proteolytic activation and intracellular 5595-5600 redistribution of the stress-signaling kinase MEKK1

Joseph C. Deak, Janet V. Cross, Margaret Lewis, Yongyi Qian, Louis A. Parrott, Clark W. Distelhorst, and Dennis J. Templeton

Polyreactive anti-DNA monoclonal antibodies and a 5601-5606 derived peptide as vectors for the intracytoplasmic and intranuclear translocation of macromolecules

Alexandre Avrameas, Th6rese Ternynck, Faridabano Nato, G6rard Buttin, and Stratis Avrameas

The rate of telomere sequence loss in human 5607-5610 leukocytes varies with age

Robert W. Frenck, Jr., Elizabeth H. Blackburn, and Kevin M. Shannon

DEVELOPMENTAL BIOLOGY

Development of normal mice from metaphase I 5611-5615 oocytes fertilized with primary spermatocytes

Atsuo Ogura, Osamu Suzuki, Kentaro Tanemura, Keiji Mochida, Yoshiro Kobayashi, and Junichiro Matsuda

Diapause-specific gene expression in pupae of the 5616-5620 flesh fly Sarcophaga crassipalpis

Ronald D. Flannagan, Steven P. Tammariello, Karl H. Joplin, Rebecca A. Cikra-Ireland, George D. Yocum, and David L. Denlinger

Glucocorticoids are insufficient for neonatal gene 5621-5625 induction in the liver

Habib Sassi, Raymond Pictet, and Thierry Grange

Wnt signaling and transcriptional control of Siamois in 5626-5631 Xenopus embryos

Melinda J. Fan, Wolfram Grining, Gerd Walz, and Sergei Y. Sokol

ECOLOGY

Biodiversity and ecosystem functioning: 5632-5636 A mechanistic model

Michel Loreau

EVOLUTION

Nucleotide sequence diversity at the alcohol 5637-5642 dehydrogenase 1 locus in wild barley (Hordeum vulgare ssp. spontaneum; An evaluation of the background selection hypothesis

Michael P. Cummings and Michael T. Clegg

Intraspecific heterochrony and life history evolution: 5643-5648 Decoupling somatic and sexual development in a facultatively paedomorphic salamander

Travis J. Ryan and Raymond D. Semlitsch

A test of the background selection hypothesis based 5649-5654 on nucleotide data from Drosophila ananassae

Wolfgang Stephan, Lin Xing, David A. Kirby, and John M. Braverman

Locomotion and body proportions of the 5836-5840 Saint-Cesaire 1 Chatelperronian Neandertal

Erik Trinkaus, Christopher B. Ruff, Steven E. Churchill, and Bernard Vandermeersch

GENETICS

A Myb homologue, ATRI, activates tryptophan gene 5655-5660 expression in Arabidopsis

Judith Bender and Gerald R. Fink

Screening for overlapping bacterial artificial 5661-5666 chromosome clones by PCR analysis with an arbitrary primer

Jichen Xu, Daichang Yang, Jessica Domingo, Junjian Ni, and Ning Huang

Humanizing the yeast telomerase template 5667-5671 Karla A. Henning, Naomi Moskowitz, Melissa A. Ashlock, and Pu P. Liu

Neuronal defects and delayed wound healing in mice 5672-5677 lacking fibroblast growth factor 2

Sagrario Ortega, Michael Ittmann, Stephen H. Tsang, Michelle Ehrlich, and Claudio Basilico

MMS2, encoding a ubiquitin-conjugating-enzyme-like 5678-5683 protein, is a member of the yeast error-free postreplication repair pathway

Stacey Broomfield, Barbara L. Chow, and Wei Xiao

Identification of a cAMP-dependent protein kinase 5684-5689 catalytic subunit required for virulence and morphogenesis in Ustilago maydis

Franz Duirrenberger, Katherine Wong, and James W. Kronstad

IMMUNOLOGY

Natural killer-like nonspecific tumor cell lysis 5690-5693 mediated by specific ligand-activated Vcx14 NKT cells

Tetsu Kawano, Junqing Cui, Yasuhiko Koezuka, Isao Toura, Yoshikatsu Kaneko, Hiroshi Sato, Eisuke Kondo, Michishige Harada, Haruhiko Koseki, Toshinori Nakayama, Yujiro Tanaka, and Masaru Taniguchi

Alternative splicing of rearranged T cell receptor 8 5694-5699 sequences to the constant region of the ax locus

Ferenc Livak and David G. Schatz

The mosquito Anopheles stephensi limits malaria 5700-5705 parasite development with inducible synthesis of nitric oxide

Shirley Luckhart, Yoram Vodovotz, Liwang Cui, and Ronald Rosenberg

Interactions with multiple peptide ligands determine 5706-5711 the fate of developing thymocytes

Owen Williams, Raquel Tarazona, Andreas Wack, Nicola Harker, Kathleen Roderick, and Dimitris Kioussis

viii

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Contents

MEDICAL SCIENCES

Fibroblast growth factor receptor 1 is fused to FIM in 5712-5717 stem-cell myeloproliferative disorder with t(8;13)(pl2;ql2)

Cornel Popovici, Jos6 Adelaide, Vincent Ollendorff, Max Chaffanet, G6raldine Guasch, Michele Jacrot, Dominique Leroux, Daniel Birnbaum, and Marie-Josephe Pebusque

Activation of NF-KB via a Src-dependent 5718-5723 Ras-MAPK-pp9Orsk pathway is required for Pseudomonas aeruginosa-induced mucin overproduction in epithelial cells

Jian-Dong Li, Weijun Feng, Marianne Gallup, Jae-Ho Kim, James Gum, Young Kim, and Carol Basbaum

Drug resistance of human glioblastoma cells conferred 5724-5729 by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases

Motoo Nagane, Alexander Levitzki, Aviv Gazit, Webster K. Cavenee, and H.-J. Su Huang

Chromosomal instability in the descendants of 5730-5733 unirradiated surviving cells after ax-particle irradiation

S. A. Lorimore, M. A. Kadhim, D. A. Pocock, D. Papworth, D. L. Stevens, D. T. Goodhead, and E. G. Wright

Genetic induction of immune tolerance to human 5734-5739 clotting factor VIII in a mouse model for hemophilia A

Gregory L. Evans and Richard A. Morgan

CCR5 coreceptor utilization involves a highly 5740-5745 conserved arginine residue of HIV type 1 gpl20

Wei-Kung Wang, Tim Dudek, Yun-Juan Zhao, Hunter G. Brumblay, Max Essex, and Tun-Hou Lee

MICROBIOLOGY

Host cell dependence of viral morphology 5746-5751 Paul C. Roberts and Richard W. Compans

A bacterial two-hybrid system based on a 5752-5756 reconstituted signal transduction pathway

Gouzel Karimova, Josette Pidoux, Agnes Ullmann, and Daniel Ladant

Isolation of a hepadnavirus from the woolly monkey, 5757-5761 a New World primate

Robert E. Lanford, Deborah Chavez, Kathleen M. Brasky, Roy B. Burns III, and Rebeca Rico-Hesse

Processing of the Ebola virus glycoprotein by the 5762-5767 proprotein convertase furin

Viktor E. Volchkov, Heinz Feldmann, Valentina A. Volchkova, and Hans-Dieter Klenk

NEUROBIOLOGY

Trends in odor intensity for human and electronic 5442-5447 noses: Relative roles of odorant vapor pressure vs. molecularly specific odorant binding

Brett J. Doleman, Erik J. Severin, and Nathan S. Lewis

Increased calpain expression in activated glial and 5768-5772 inflammatory cells in experimental allergic encephalomyelitis

Donald C. Shields, William R. Tyor, Gladys E. Deibler, Edward L. Hogan, and Naren L. Banik

Nitric oxide mediates N-methyl-D-aspartate 5773-5778 receptor-induced activation of p2lras

Hye-Young Yun, Mirella Gonzalez-Zulueta, Valina L. Dawson, and Ted M. Dawson

Neurotrophins inhibit major histocompatibility class II 5779-5784 inducibility of microglia: Involvement of the p75 neurotrophin receptor

Harald Neumann, Thomas Misgeld, Kenji Matsumuro, and Hartmut Wekerle

Alleviation of x-irradiation-based deficit in 5785-5788 memory-based learning by D-amphetamine: Suggestions for attention deficit-hyperactivity disorder

D. A. Highfield, D. Hu, and A. Amsel

Transgenic mice expressing human Bcl-2 in their 5789-5794 neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity

Daniel Offen, Philip M. Beart, Nam S. Cheung, Catherine J. Pascoe, Ayala Hochman, Svetlana Gorodin, Eldad Melamed, Rozenn Bernard, and Ora Bernard

Amyloid ,3-peptide stimulates nitric oxide production 5795-5800 in astrocytes through an NFKB-dependent mechanism

Keith T. Akama, Chris Albanese, Richard G. Pestell, and Linda J. Van Eldik

GFRcx3 is an orphan member of the 5801-5806 GDNF/neurturin/persephin receptor family

Robert H. Baloh, Alexander Gorodinsky, Judith P. Golden, MauI G. Tansey, Catherine L. Keck, Nicholas C. Popescu, Eugene M. Johnson, Jr., and Jeffrey Milbrandt

Morphine disrupts long-range synchrony of gamma 5807-5811 oscillations in hippocampal slices

M. A. Whittington, R. D. Traub, H. J. Faulkner, J. G. R. Jefferys, and K. Chettiar

PLANT BIOLOGY

ETR2 is an ETR1-like gene involved in ethylene 5812-5817 signaling inArabidopsis

Hajime Sakai, Jian Hua, Qianhong G. Chen, Caren Chang, Leonard J. Medrano, Anthony B. Bleecker, and Elliot M. Meyerowitz

Defense activation and enhanced pathogen tolerance 5818-5823 induced by H202 in transgenic tobacco

Sangpen Chamnongpol, Hilde Willekens, Wolfgang Moeder, Christian Langebartels, Heinrich Sandermann, Jr., Marc Van Montagu, Dirk Inze, and Wim Van Camp

DNA methylation and the promotion of flowering by 5824-5829 vernalization

E. J. Finnegan, R. K. Genger, K. Kovac, W. J. Peacock, and E. S. Dennis

ix

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Contents

Chlorophyll a availability affects psbA translation and 5830-5835 Dl precursor processing in vivo in Synechocystis sp. PCC 6803

Qingfang He and Wim Vermaas

Social Sciences

ANTHROPOLOGY

Locomotion and body proportions of the 5836-5840 Saint-Cesaire 1 Chatelperronian Neandertal

Erik Trinkaus, Christopher B. Ruff, Steven E. Churchill, and Bernard Vandermeersch

CORRECTIONS

BIOCHEMISTRY

Escherichia coli RNA polymerase terminates 5841 transcription efficiently at rho-independent terminators on single-stranded DNA templates

Susan M. Uptain and Michael J. Chamberlin

Characterization of residual structure in the thermally 5841 denatured state of barnase by simulation and experiment: Description of the folding pathway

Chris J. Bond, Kam-Bo Wong, Jane Clarke, Alan R. Fersht, and Valerie Daggett

Negative control of bacterial DNA replication by a 5841 cell cycle regulatory protein that binds at the chromosome origin

Kim C. Quon, Bing Yang, Ibrahim J. Domian, Lucy Shapiro, and Gregory T. Marczynski

The 30-kDa C-terminal domain of the RecB protein is 5841 critical for the nuclease activity, but not the helicase activity, of the RecBCD enzyme from Escherichia coli

Misook Yu, Jehanne Souaya, and Douglas A. Julin

CELL BIOLOGY

Scavenger receptor class B, type I (SR-BI) is the 5841 major route for the delivery of high density lipoprotein cholesterol to the steroidogenic pathway in cultured mouse adrenocortical cells

Ryan E. Temel, Bernardo Trigatti, Ronald B. DeMattos, Salman Azhar, Monty Krieger, and David L. Williams

Identification of a family of low-affinity insulin-like 5842 growth factor binding proteins (IGFBPs): Characterization of connective tissue growth factor as a member of the IGFBP superfamily

Ho-Seong Kim, Srinivasa R. Nagalla, Youngman Oh, Elizabeth Wilson, Charles T. Roberts, Jr., and Ron G. Rosenfeld

IMMUNOLOGY

Parasite-mediated nuclear factor KB regulation 5842 in lymphoproliferation caused by Theileria parva infection

Guy H. Palmer, Joel Machado, Jr., Paula Fernandez, Volker Heussler, Therese Perinat, and Dirk A. E. Dobbelaere

NEUROBIOLOGY

Hair cell-specific splicing of mRNA for the alD 5842 subunit of voltage-gated Ca2+ channels in the chicken's cochlea

Richard Kollmar, John Fak, Lisa G. Montgomery, and A. J. Hudspeth

AUTHOR INDEX xi-xii

INFORMATION FOR AUTHORS xiii-xv

SIZING WORKSHEET xvi

SUBSCRIPTION FORM xvii

COPYRIGHT ASSIGNMENT FORM xviii

CLASSIFIED ADVERTISEMENTS xix-xxii

x

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