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Front Matter Source: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, No. 24 (Nov. 24, 1998), pp. i-viii Published by: National Academy of Sciences Stable URL: http://www.jstor.org/stable/46474 . Accessed: 07/05/2014 21:25 Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at . http://www.jstor.org/page/info/about/policies/terms.jsp . JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact [email protected]. . National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access to Proceedings of the National Academy of Sciences of the United States of America. http://www.jstor.org This content downloaded from 169.229.32.136 on Wed, 7 May 2014 21:25:03 PM All use subject to JSTOR Terms and Conditions
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Page 1: Front Matter

Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 95, No. 24 (Nov. 24, 1998), pp. i-viiiPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/46474 .

Accessed: 07/05/2014 21:25

Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at .http://www.jstor.org/page/info/about/policies/terms.jsp

.JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range ofcontent in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new formsof scholarship. For more information about JSTOR, please contact [email protected].

.

National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access toProceedings of the National Academy of Sciences of the United States of America.

http://www.jstor.org

This content downloaded from 169.229.32.136 on Wed, 7 May 2014 21:25:03 PMAll use subject to JSTOR Terms and Conditions

Page 2: Front Matter

PROCEEDINGS

OF THE

NATIONAL ACADEMY OF SCIENCES

OF THE UNITED STATES OF AMEJRICA

November 24, 1998

Volume 95/ Number 24

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Page 3: Front Matter

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Page 4: Front Matter

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Page 5: Front Matter

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Page 6: Front Matter

PROCEEDINGS

OF THE

NATIO)NAL ACADEMY OF S CIENCES

OF THE UNITED STATES OF AMERICA

November 24, 1998 Volume 95, Number 24 pp. 13999-14586

Table of Contents

Commentaries

The rise of single-molecule DNA biochemistry 13999-14000 Alexander Rich * See companion article on page 14152

T cell receptor antagonism in vivo, at last 14001-14002 Stephen C. Jameson * See companion article on page 14332

Mass migration of a group I intron: Promiscuity 14003-14005 on a grand scale

Michael W. Gray * See companion article on page 14244

Interactions of Salmonella with host cells: Encounters 14006-14008 of the closest kind

Jorge E. Galan * See companion article on page 14057

Inaugural Article Paleoindian large mammal hunters on the plains of 14576-14583 North America

George C. Frison

Physical Sciences

APPLIED PHYSICAL SCIENCES

Hypsographic demography: The distribution of 14009-14014 human population by altitude

Joel E. Cohen and Christopher Small

Ultrasonic tagging of light: Theory 14015-14019 G. D. Mahan, W. E. Engler, J. J. Tiemann, and E. Uzgiris

CHEMISTRY

Inhibition of dipeptidyl peptidase IV by 14020-14024 fluoroolefin-containing N-peptidyl-O-hydroxylamine peptidomimetics

Jian Lin, Paul J. Toscano, and John T. Welch

MATHEMATICS

Regular and stochastic dynamics in the real 14025-14027 quadratic family

Mikhail Lyubich

Biological Sciences

AGRICULTURAL SCIENCES

Transgenic cattle produced by reverse-transcribed 14028-14033 gene transfer in oocytes

Anthony W. S. Chan, E. Jane Homan, Linda U. Ballou, Jane C. Burns, and Robert D. Bremel

The pir gene of Erwinia chrysanthemi EC16 regulates 14034-14039 hyperinduction of pectate lyase virulence genes in response to plant signals

Kinya Nomura, William Nasser, Hirokazu Kawagishi, and Shinji Tsuyumu

iii

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Page 7: Front Matter

Contents

Insecticide resistance resulting from an absence of 14040-14044 target-site gene product

Thomas G. Wilson and Mudgapalli Ashok

BIOCHEMISTRY

Structural basis for efficient phosphorylation of 14045-14050 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase

Arnon Lavie, Nils Ostermann, Ralf Brundiers, Roger S. Goody, Jochen Reinstein, Manfred Konrad, and Ilme Schlichting

In vitro selection of RNA molecules that displace 14051-14056 cocaine from the membrane-bound nicotinic acetylcholine receptor

Henning Ulrich, Joseph E. Ippolito, On6 R. Pagain, Vesna A. Eterovic, Richard M. Hann, Hua Shi, John T. Lis, Mohyee E. Eldefrawi, and George P. Hess

SopB, a protein required for virulence of Salmonella 14057-14059 dublin, is an inositol phosphate phosphatase

F. Anderson Norris, Monita P. Wilson, Timothy S. Wallis, Edouard E. Galyov, and Philip W. Majerus * See Commentary on page 14006

A transmembrane form of annexin XII detected by 14060-14065 site-directed spin labeling

Rali Langen, J. Mario Isas, Wayne L. Hubbell, and Harry T. Haigler

DNA end-joining catalyzed by human 14066-14070 cell-free extracts

Peter Baumann and Stephen C. West

Overexpression of peptide-methionine sulfoxide 14071-14075 reductase in Saccharomyces cerevisiae and human T cells provides them with high resistance to oxidative stress

Jackob Moskovitz, Eliezer Flescher, Barbara S. Berlett, Janeen Azare, J. Michael Poston, and Earl R. Stadtman

The orientation of the AP-1 heterodimer on DNA 14076-14081 strongly affects transcriptional potency

Milan Chytil, Blake R. Peterson, Daniel A. Erlanson, and Gregory L. Verdine

032-Adrenergic receptor regulation by GITI, a G 14082-14087 protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein

Richard T. Premont, Audrey Claing, Nicolas Vitale, Jennifer L. R. Freeman, Julie A. Pitcher, Walter A. Patton, Joel Moss, Martha Vaughan, and Robert J. Lefkowitz

A pyrimidine-rich exonic splicing suppressor binds 14088-14093 multiple RNA splicing factors and inhibits spliceosome assembly

Zhi-Ming Zheng, Martijn Huynen, and Carl C. Baker

Protein tyrosine phosphatase PTP1B suppresses p210 14094-14099 bcr-abl-induced transformation of Rat-i fibroblasts and promotes differentiation of K562 cells

Kenneth R. LaMontagne, Jr., Greg Hannon, and Nicholas K. Tonks

Nitrosative stress: Metabolic pathway involving 14100-14105 the flavohemoglobin

Alfred Hausladen, Andrew J. Gow, and Jonathan S. Stamler

The f subunit sliding DNA clamp is responsible for 14106-14111 unassisted mutagenic translesion replication by DNA polymerase III holoenzyme

Guy Tomer, Nina Bacher Reuven, and Zvi Livneh

Multiple domains of repressor activator protein 1 14112-14117 contribute to facilitated binding of glycolysis regulatory protein 1

M. Cecilia L6pez, Jeffery B. Smerage, and Henry V. Baker

Host factor I, Hfq, binds to Escherichia coli ompA 14118-14123 mRNA in a growth rate-dependent fashion and regulates its stability

Oresta Vytvytska, Jimmy S. Jakobsen, Gina Balcunaite, Jens S. Andersen, Manuela Baccarini, and Alexander von Gabain

Filament structure as an essential factor for 14124-14129 regulation of Dictyostelium myosin by regulatory light chain phosphorylation

Xiong Liu, Kohji Ito, Sayuri Morimoto, Atsuko Hikkoshi-Iwane, Toshio Yanagida, and Taro 0. P. Uyeda

Ribosome display efficiently selects and evolves 14130-14135 high-affinity antibodies in vitro from immune libraries

Jozef Hanes, Lutz Jermutus, Susanne Weber-Bornhauser, Hans Rudolf Bosshard, and Andreas Pluickthun

A functional homolog of a yeast tRNA splicing 14136-14141 enzyme is conserved in higher eukaryotes and in Escherichia coli

Sherry L. Spinelli, Harmit S. Malik, Sandra A. Consaul, and Eric M. Phizicky

BIOPHYSICS

A transient expansion of the native state precedes 14142-14146 aggregation of recombinant human interferon-y

Brent S. Kendrick, John F. Carpenter, Jeffrey L. Cleland, and Theodore W. Randolph

NMR scalar couplings across Watson-Crick base pair 14147-14151 hydrogen bonds in DNA observed by transverse relaxation-optimized spectroscopy

Konstantin Pervushin, Akira Ono, C6sar Fernandez, Thomas Szyperski, Masatsune Kainosho, and Kurt Wuithrich

Stretched and overwound DNA forms a Pauling-like 14152-14157 structure with exposed bases

J. F. Allemand, D. Bensimon, R. Lavery, and V. Croquette * See Commentary on page 13999

iv

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Page 8: Front Matter

Contents

CELL BIOLOGY

A widely expressed (3111 spectrin associated with 14158-14163 Golgi and cytoplasmic vesicles

Michael C. Stankewich, Williarri T. Tse, Luanne L. Peters, Yeang Ch'ng, Kathryn M. John, Paul R. Stabach, Prasad Devarajan, Jon S. Morrow, and Samuel E. Lux

Quantitative insight into proliferation and 14164-14167 differentiation of oligodendrocyte type 2 astrocyte progenitor cells in vitro

Andrej Y. Yakovlev, Kenneth Boucher, Margot Mayer-Proschel, and Mark Noble

Insulin depletion leads to adipose-specific cell death 14168-14172 in obese but not lean mice

Thomas M. Loftus, Francis P. Kuhajda, and M. Daniel Lane

Nucleosomes, linker DNA, and linker histone form a 14173-14178 unique structural motif that directs the higher-order folding and compaction of chromatin

Jan Bednar, Rachel A. Horowitz, Sergei A. Grigoryev, Lenny M. Carruthers, Jeffrey C. Hansen, Abraham J. Koster, and Christopher L. Woodcock

An essential role of phosphatidylinositol 3-kinase in 14179-14183 myogenic differentiation

Bing-Hua Jiang, Jenny Z. Zheng, and Peter K. Vogt

Unmasking the functions of the chromaffin cell a7 14184-14189 nicotinic receptor by using short pulses of acetylcholine and selective blockers

Manuela G. L6pez, Carmen Montiel, Carlos J. Herrero, Esther Garcia-Palomero, Ines Mayorgas, Jesus M. Hernandez-Guijo, M. Villarroya, Roman Olivares, Luis Gandia, J. Michael McIntosh, Baldomero M. Olivera, and Antonio G. Garcia

A theory for controlling cell cycle dynamics using a 14190-14195 reversibly binding inhibitor

Timothy S. Gardner, Milos Dolnik, and James J. Collins

Tumor necrosis factor-ae induces adhesion molecule 14196-14201 expression through the sphingosine kinase pathway

Pu Xia, Jennifer R. Gamble, Kerry-Anne Rye, Lijun Wang, Charles S. T. Hii, Peter Cockerill, Yeesim Khew-Goodall, Andrew G. Bert, Philip J. Barter, and Mathew A. Vadas

Inhibition of tumorigenicity of the teratoma PC cell 14202-14207 line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor)

Haidi Zhang and Ginette Serrero

DEVELOPMENTAL BIOLOGY

Testatin: A cystatin-related gene expressed during 14208-14213 early testis development

Virpi Tohonen, Christina Osterlund, and Katarina Nordqvist

Endothelin 3 selectively promotes survival and 14214-14219 proliferation of neural crest-derived glial and melanocytic precursors in vitro

Ronit Lahav, Elisabeth Dupin, Laure Lecoin, Corinne Glavieux, Delphine Champeval, Catherine Ziller, and Nicole M. Le Douarin

Expression of myogenin during embryogenesis is 14220-14225 controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site

Francois Spitz, Josiane Demignon, Arlette Porteu, Axel Kahn, Jean-Paul Concordet, Dominique Daegelen, and Pascal Maire

EVOLUTION

Complete mitochondrial genome suggests diapsid 14226-14231 affinities of turtles

Rafael Zardoya and Axel Meyer

Genetic control of social organization in an ant 14232-14237 Kenneth G. Ross and Laurent Keller

Persistence of neutral polymorphisms in Lake 14238-14243 Victoria cichlid fish

Sandra Nagl, Herbert Tichy, Werner E. Mayer, Naoyuki Takahata, and Jan Klein

Explosive invasion of plant mitochondria by a group 14244-14249 I intron

Yangrae Cho, Yin-Long Qiu, Peter Kuhlman, and Jeffrey D. Palmer M See Commentary on page 14003

A heterodimeric DNA polymerase: Evidence that 14250-14255 members of Euryarchaeota possess a distinct DNA polymerase

Isaac K. 0. Cann, Kayoko Komori, Hiroyuki Toh, Satoru Kanai, and Yoshizumi Ishino

Stomatal plugs of Drimys winteri (Winteraceae) 14256-14259 protect leaves from mist but not drought

Taylor S. Feild, Maciej A. Zwieniecki, Michael J. Donoghue, and N. Michele Holbrook

Complexities in the genetic structure of Anopheles 14260-14265 gambiae populations in west Africa as revealed by microsatellite DNA analysis

Gregory C. Lanzaro, Yeya T. Toure, John Carnahan, Liangbiao Zheng, Guimogo Dolo, Sekou Traore, Vincenzo Petrarca, Kenneth D. Vernick, and Charles E. Taylor

Somatic hypermutation of the new antigen receptor 14343-14348 gene (NAR) in the nurse shark does not generate the repertoire: Possible role in antigen-driven reactions in the absence of germinal centers

Marilyn Diaz, Andrew S. Greenberg, and Martin F. Flajnik

GENETICS

Targeting cyclin-dependent kinases in Drosophila 14266-14271 with peptide aptamers

Mikhail G. Kolonin and Russell L. Finley, Jr.

An artificial cell-cycle inhibitor isolated from a 14272-14277 combinatorial library

Barak A. Cohen, Pierre Colas, and Roger Brent

v

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Page 9: Front Matter

Contents

Physical interaction between components of DNA 14278-14283 mismatch repair and nucleotide excision repair

Pascale Bertrand, Daniel X. Tishkoff, Nicole Filosi, Ruchira Dasgupta, and Richard D. Kolodner

The role of alternative mRNA splicing in generating 14284-14289 heterogeneity within the Anopheles gambiae class I glutathione S-transferase family

Hilary Ranson, Frank Collins, and Janet Hemingway

Tsetse thrombin inhibitor: Bloodmeal-induced 14290-14295 expression of an anticoagulant in salivary glands and gut tissue of Glossina niorsitans miorsitans

Michael Cappello, Song Li, Xiaoai Chen, Chang-Ben Li, Lisa Harrison, Sukanya Narashimhan, Charles B. Beard, and Serap Aksoy

Chromosomal arm replacement generates a high level 14296-14301 of intraspecific polymorphism in the terminal inverted repeats of the linear chromosomal DNA of StUeptolyces ambofaciens

Gilles Fischer, Thomas Wenner, Bernard Decaris, and Pierre Leblond

Autoregulation at the level of mRNA 3' end 14302-14307 for-mation of the suppressor of forked gene of Dr-osophila mielanogaster is conserved in Drosophila vi/ilis

Agnes Audibert and Martine Simonelig

IMMUNOLOGY

Activation of human monocytes induces differential 14308-14313 resistance to apoptosis with rapid down regulation of caspase-8/FLICE

Liyanage P. Perera and Thomas A. Waldmann

Presentation of peptide antigens by mouse CD1 14314-14319 requires ondosomal localization and protein antigen processing

Shabnam Tangri, Laurent Brossay, Nicolas Burdin, Delphine J. Lee, Maripat Corr, and Mitchell Kronenberg

Altered peptide ligands act as partial agonists by 14320-14325 inhibiting phospholipase C activity induced by myasthenogenic T cell epitopes

Anat Faber-Elmann, Miri Paas-Rozner, Michael Sela, and Edna Mozes

Differential binding to HLA-C of p50-activating and 14326-1-4331 p58-inhibitory natural killer cell receptors

Mar Va1es-G6mez, Hugh T. Reyburn, Robert A. Erskine, and Jack Strominger

In vivo antagonism of a T cell response by an 14332-14336 endogenously expressed ligand

Devraj Basu, Calvin B. Williams, and Paul M. Allen * See Commentaiy on page 1400!

Analysis of the Drosophila host defense in domino 14337-14342 mutant larvae, which are devoid of hemocytes

Anne Braun, Jules A. Hoffmann, and Marie Meister

Somatic hypermutation of the new antigen receptor 14343-14348 gene (NAR) in the nurse shark does not generate the repertoire: Possible role in antigen-driven reactions in the absence of germinal centers

Marilyn Diaz, Andrew S. Greenberg, and Martin F. Flajnik

Inhibition of intrathymic T cell development by 14349-14354 expression of a transgenic antagonist peptide

Christiaan N. Levelt, Emiko Mizoguchi, Xin Huang, Rebecca Zacks, Atul K. Bhan, and Susumu Tonegawa

MEDICAL SCIENCES

HIV type-i infection of the cotton rat (Sigmodon 14355-14360

ftilviventer and S. hispidus) Raymond J. Langley, Gregory A. Prince, and Harold S. Ginsberg

Identification of morc (micror-chidia), a mutation that 14361-1.4366 results in arrest of spermatogenesis at an early meiotic stage in the mouse

Mark L. Watson, Andrew R. Zinn, Norimitsu Inoue, Karl D. Hess, John Cobb, Mary Ann Handel, Ruth Halaban, Clark C. Duchene, George M. Albright, and Randall W. Moreadith

Endothelin ETA receptor blockade restores 14367-14372 NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice

Matthias Barton, Christian C. Haudenschild, Livius V. d'Uscio, Sidney Shaw, Klaus Munter, and Thomas F. Luscher

Vasoactive intestinal peptide inhibits human small-cell 14373-14378 lung cancer proliferation in vitro and in vivo

Kaname Maruno, Afaf Absood, and Sami I. Said

Uncoupling signal transducers from oncogenic MET 14379-14383 mutants abrogates cell transformation and inhibits invasive growth

Alberto Bardelli, Paola Longati, Daniela Gramaglia, Cristina Basilico, Luca Tamagnone, Silvia Giordano, Dario Ballinari, Paolo Michieli, and Paolo M. Comoglio

Sustained secretion of human alpha-1-antitrypsin from 14384-14388 murine muscle transduced with adeno-associated virus vectors

Sihong Song, Michael Morgan, Tamir Ellis, Amy Poirier, Kye Chesnut, Jianming Wang, Mark Brantly, Nicholas Muzyczka, Barry J. Byrne, Mark Atkinson, and Terence R. Flotte

Vascular endothelial growth factor C induces 14389-14394 anigiogenesis in vivo

Yihai Cao, Philip Linden, Jacob Farnebo, Renhai Cao, Anna Eriksson, Vijay Kumar, Jian-Hua Qi, Lena Claesson-Welsh, and Kari Alitalo

Liver degeneration and lymphoid deficiencies in mice 14395-14399 lacking suppressor of cytokine signaling-I

Robyn Starr, Donald Metcalf, Andrew G. Elefanty, Marta Brysha, Tracy A. Wilison, Nicos A. Nicola, Douglas J. Hilton, and Warren S. Alexander

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Contents

The cancer growth suppressor gene mda-7 selectively 14400-14405 induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice

Zao-zhong Su, Malavi T. Madireddi, Jiao Jiao Lin, Charles S. H. Young, Shinichi Kitada, John C. Reed, Neil I. Goldstein, and Paul B. Fisher

Functional analyses of troponin T mutations that 14406-14410 cause hypertrophic cardiomyopathy: Insights into disease pathogenesis and troponin function

H. Lee Sweeney, Huisheng S. Feng, Zhaouhui Yang, and Hugh Watkins

Interferon-/3 gene therapy inhibit.s tumor formation 14411-14416 and causes regression of established tumors in immune-deficient mice

Xiao-Qiang Qin, Nianjun Tao, Amie Dergay, Pamela Moy, Stephen Fawell, Alan Davis, James M. Wilson, and James Barsoum

The mutationally activated Met receptor mediates 14417-14422 motility and metastasis

Michael Jeffers, Michele Fiscella, Craig P. Webb, Miriam Anver, Shahriar Koochekpour, and George F. Vande Woude

Endothelial selectins and vascular cell adhesion 14423-14428 molecule-i promote hematopoietic progenitor homing to bone marrow

Paul S. Frenette, Sangeetha Subbarao, Irina B. Mazo, Ulrich H. von Andrian, and Denisa D. Wagner

Fetuin (ca2-HS-glycoprotein) opsonizes cationic 14429-14434 macrophage-deactivating molecules

Haichao Wang, Minghuang Zhang, Marina Bianchi, Barbara Sherry, Andrew Sama, and Kevin J. Tracey

The neutral glycosphingolipid globotriaosylceramide 14435-14440 promotes fusion mediated by a CD4-dependent CXCR4-utilizing HIV type 1 envelope glycoprotein

Anu Puri, Peter Hug, Kristine Jernigan, Joseph Barchi, Hee-Yong Kim, Jillon Hamilton, Joelle Wiels, Gary J. Murray, Roscoe 0. Brady, and Robert Blumenthal

Stochastic processes strongly influence HIV-1 14441-14446 evolution during suboptimal protease-inhibitor therapy

Monique Nijhuis, Charles A. B. Boucher, Pauline Schipper, Thomas Leitner, Rob Schuurman, and Jan Albert

Perturbation of the T cell repert:oire in rheumatoid 14447-14452 arthritis

Ulf G. Wagner, Kerstin Koetz, Cornelia M. Weyand, and J6rg J. Goronzy

The intrinsic radioresistance of glioblastoma-derived 14453-14458 cell lines is associated with a failure of p53 to induce p2lBAX expression

Hui-Kuo G. Shu, Moses M. Kim, Pengchin Chen, Felix Furman, Carol M. Julin, and Mark A. Israel

Altered regulation of platelet-derived growth factor 14459-14463 receptor-a gene-transcription in vitro by spina bifida-associated mutant Paxi proteins

Paul H. L. J. Joosten, Frans A. Hol, Sylvia B. C. van Beersum, Heiko Peters, Ben C. J. Hamel, Gijs B. Afink, Everardus J. J. van Zoelen, and Edwin C. M. Mariman

MICROBIOLOGY

The Vibrio cholerae genome contains two unique 14464-14469 circular chromosomes

Michele Trucksis, Jane Michalski, Ying Kang Deng, and James B. Kaper

Cellular gene expression altered by human 14470-14475 cytomegalovirus: Global monitoring with oligonucleotide arrays

Hua Zhu, Jian-Ping Cong, Gargi Mamtora, Thomas Gingeras, and Thomas Shenk

NEUROBIOLOGY

Serotonin receptor IA knockout: An animal model 14476-14481 of anxiety-related disorder

Sylvie Ramboz, Ronald Oosting, Djamel Ait Amara, Hank F. Kung, Pierre Blier, Monica Mendelsohn, J. John Mann, Dani Brunner, and Ren6 Hen

Prolonged activation of the N-methyl-D-aspartate 14482-14487 receptor-Ca2+ transduction pathway causes spontaneous recurrent epileptiform discharges in hippocampal neurons in culture

Robert J. DeLorenzo, Shubhro Pal, and Sompong Sombati

Inputs to directionally selective simple cells in 14488-14493 macaque striate cortex

Russell L. De Valois and Nicolas P. Cottaris

Selective effects of methylphenidate in attention 14494-14499 deficit hyperactivity disorder: A functional magnetic resonance study

Chandan J. Vaidya, Glenn Austin, Gary Kirkorian Hugh W. Ridlehuber, John E. Desmond, Gary H. Glover, and John D. E. Gabrieli

Chemokines regulate hippocampal neuronal signaling 14500-14505 and gp120 neurotoxicity

Olimpia Meucci, Alessandro Fatatis, Arthur A. Simen, Trevor J. Bushell, Patrick W. Gray, and Richard J. Miller

Hippocampal, but not amygdala, activity at encoding 14506-14510 correlates with long-term, free recall of nonemotional information

Michael T. Alkire, Richard J. Haier, James H. Fallon, and Larry Cahill

Suppression of protein synthesis in brain during 14511-14516 hibernation involves inhibition of protein initiation and elongation

Kai U. Frerichs, Carolyn B. Smith, Michael Brenner, Donald J. DeGracia, Gary S. Krause, Laura Marrone, Thomas E. Dever, and John M. Hallenbeck

Effect of reduced myristoylated alanine-rich C kinase 14517-15422 substrate expression on hippocampal mossy fiber development and spatial learning in mutant mice: Transgenic rescue and interactions with gene background

R. K. McNamara, D. J. Stumpo, L. M. Morel, M. H. Lewis, B. K. Wakeland, P. J. Blackshear, and R. H. Lenox

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Contents

Evidence for a voltage-dependent enhancement of 14523-14528 neurotransmitter release mediated via the synaptic protein interaction site of N-type Ca2+ channels

Sumiko Mochida, Charles T. Yokoyama, D. Kyle Kim, Kanako Itoh, and William A. Catterall

A neuronal model of a global workspace in effortful 14529-14534 cognitive tasks

Stanislas Dehaene, Michel Kerszberg, and Jean-Pierre Changeux

PHARMACOLOGY

Promoting detachment of neutrophils adherent to 14535-14539 murine postcapillary venules to control inflammation: Effect of lipocortin 1

Lina H. K. Lim, Egle Solito, Frangoise Russo-Marie, Roderick J. Flower, and Mauro Perretti

Modes of action of aspirin-like drugs: Salicylates 14540-14545 inhibit Erk activation and integrin-dependent neutrophil adhesion

Michael H. Pillinger, Constance Capodici, Pamela Rosenthal, Neil Kheterpal, Simon Hanft, Mark R. Philips, and Gerald Weissmann

PHYSIOLOGY

Stoichiometry and arrangement of heteromeric 14546-14551 olfactory cyclic nucleotide-gated ion channels

Mark S. Shapiro and William N. Zagotta

The thiazide-sensitive Na-Cl cotransporter is an 14552-14557 aldosterone-induced protein

Gheun-Ho Kim, Shyama Masilamani, Rachel Turner, Carter Mitchell, James B. Wade, and Mark A. Knepper

Rat heart: A site of oxytocin production and action 14558-14563 Marek Jankowski, Fadi Hajjar, Sausan Al Kawas, Suhayla Mukaddam-Daher, Gloria Hoffman, Samuel M. McCann, and Jolanta Gutkowska

Characterization of a murine type II 14564-14569 sodium-phosphate cotransporter expressed in mammalian small intestine

Helene Hilfiker, Olaf Hattenhauer, Martin Traebert, Ian Forster, Heini Murer, and Jiurg Biber

PLANT BIOLOGY

Mode of action of the CORlSa gene on the freezing 14570-14575 tolerance of Arabidopsis thaliana

Peter L. Steponkus, Matsuo Uemura, Raymond A. Joseph, Sarah J. Gilmour, and Michael F. Thomashow

Social Sciences

ANTHROPOLOGY

Paleoindian large mammal hunters on the plains of 14576-14583 North America

George C. Frison

SOCIAL SCIENCES

Hypsographic demography: The distribution of 14009-14014 human population by altitude

Joel E. Cohen and Christopher Small

CORRECTIONS

BIOCHEMISTRY Molecular cloning and characterization of a cellular 14584 phosphoprotein that interacts with a conserved C-terminal domain of adenovirus EIA involved in negative modulation of oncogenic transformation

Ute Schaeper, Janice M. Boyd, Sulekha Verma, Erik Uhlmann, T. Subramanian, and G. Chinnadurai

The TRAP220 component of a thyroid hormone 14584 receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion

Chao-Xing Yuan, Mitsuhiro Ito, Joseph D. Fondell, Zheng-Yuan Fu, and Robert G. Roeder

EVOLUTION The role of robustness and changeability on the origin 14584 and evolution of genetic codes

Tetsuya Maeshiro and Masayuki Kumura

PLANT BIOLOGY Differential expression of two isopentenyl 14585 pyrophosphate isomerases and enhanced carotenoid accumulation in a unicellular chlorophyte

Zairen Sun, Francis X. Cunningham, Jr., and Elisabeth Gantt

AUTHOR INDEX ix-xi

INFORMATION FOR AUTHORS xii-xiv

SIZING WORKSHEET xv

DOCUMENTATION REPORT xvi

COPYRIGHT ASSIGNMENT FORM xvii

SUBSCRIPTION FORM xviii

CLASSIFIED ADVERTISEMENTS xix

Cover photograph: Euclid, the father of geometry: Panel from the bronze doors at the National Academy of Sciences.

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