Front Matter Source: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 2 (Jan. 19, 1999), pp. i-viii Published by: National Academy of Sciences Stable URL: http://www.jstor.org/stable/46804 . Accessed: 03/05/2014 23:38 Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at . http://www.jstor.org/page/info/about/policies/terms.jsp . JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact [email protected]. . National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access to Proceedings of the National Academy of Sciences of the United States of America. http://www.jstor.org This content downloaded from 130.132.123.28 on Sat, 3 May 2014 23:38:17 PM All use subject to JSTOR Terms and Conditions
Transcript
Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 96, No. 2 (Jan. 19, 1999), pp. i-viiiPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/46804 .
Accessed: 03/05/2014 23:38
Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at .http://www.jstor.org/page/info/about/policies/terms.jsp
.JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range ofcontent in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new formsof scholarship. For more information about JSTOR, please contact [email protected].
.
National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access toProceedings of the National Academy of Sciences of the United States of America.
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This content downloaded from 130.132.123.28 on Sat, 3 May 2014 23:38:17 PMAll use subject to JSTOR Terms and Conditions
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Plugging the leaks 319-321 Daniel A. Goodenough * See companion article on page 511
No milk today (my Hox have gone away) 322-323 Denis Duboule * See companion article on page 541
Development of optimized vectors for gene therapy 324-326 Gary J. Nabel * See companion article on page 355
Genetic code origins: Experiments confirm 327-328 phylogenetic predictions and may explain a puzzle
Paul Schimmel and Lluis Ribas de Pouplana * See companion article on page 418
Protein kinase A takes center stage in 329-331 ATP-dependent insulin secretion
Thomas A. Blanpied and George J. Augustine * See companion article on page 760
Extending the size limit of protein nuclear 332-334 magnetic resonance
Hongtao Yu * See companion article on page 388
The fyn art of N-methyl-D-aspartate 335-337 receptor phosphorylation
Carlo Sala and Morgan Sheng * See companion article on page 435
Inaugural Article
Groucho and dCtBP mediate separate pathways of 535-540 transcriptional repression in the Drosophila embryo
Hailan Zhang and Michael Levine
Physical Sciences
CHEMISTRY
Ultrafast electron diffraction and direct observation of 338-342 transient structures in a chemical reaction
Jianming Cao, Hyotcherl Ihee, and Ahmed H. Zewail
Biological Sciences
BIOCHEMISTRY
Persistence of an alternate chromatin structure at 343-348 silenced loci in vitro
Athar Ansari and Marc R. Gartenberg
Tissue-specific and developmental stage-specific DNA 349-354 binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching
David O'Neill, John Yang, Hediye Erdjument-Bromage, Katherine Bornschlegel, Paul Tempst, and Arthur Bank
iii
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Contents Adenovirus-mediated regulable target gene expression 355-360 in vivo
Mark M. Burcin, Gudrun Schiedner, Stefan Kochanek, Sophia Y. Tsai, and Bert W. O'Malley U See Commentary on page 324
Silicatein filaments and subunits from a marine 361-365 sponge direct the polymerization of silica and silicones in vitro
Jennifer N. Cha, Katsuhiko Shimizu, Yan Zhou, Sean C. Christiansen, Bradley F. Chmelka, Galen D. Stucky, and Daniel E. Morse
Site-directed hydroxyl radical probing of 30S 366-370 ribosomal subunits by using Fe(II) tethered to an interruption in the 16S rRNA chain
Raymond R. Samaha, Simpson Joseph, Bonnie O'Brien, Thomas W. O'Brien, and Harry F. Noller
Antitumor activity of mannan-binding protein in vivo 371-375 as revealed by a virus expression system: Mannan-binding protein-dependent cell-mediated cytotoxicity
The Medl subunit of the yeast mediator complex 376-381 is involved in both transcriptional activation and repression
Darius Balciunas, Cecilia Galman, Hans Ronne, and Stefan Bj6rklund
Interaction between cyclin-dependent kinases and 382-387 human papillomavirus replication-initiation protein El is required for efficient viral replication
Tianlin Ma, Nianxiang Zou, Biing Yuan Lin, Louise T. Chow, and J. Wade Harper
Chemical ligation of folded recombinant proteins: 388-393 Segmental isotopic labeling of domains for NMR studies
Rong Xu, Brenda Ayers, David Cowburn, and Tom W. Muir U See Commentary on page 332
Myosin I heavy chain kinase: Cloning of the 394-399 full-length gene and acidic lipid-dependent activation by Rac and Cdc42
Hanna Brzeska, Rachel Young, Ulla Knaus, and Edward D. Korn
Asparagine and glutamine rotamers: B-factor cutoff 400-405 and correction of amide flips yield distinct clustering
Simon C. Lovell, J. Michael Word, Jane S. Richardson, and David C. Richardson
A f-1,3-N-acetylglucosaminyltransferase with 406-411 poly-N-acetyllactosamine synthase activity is structurally related to 0-1,3-galactosyltransferases
Dapeng Zhou, Andr6 Dinter, Ricardo Guti6rrez Gallego, Johannis P. Kamerling, Johannes F. G. Vliegenthart, Eric G. B3erger, and Thierry Hennet
Persistent membrane association of activated and 412-417 depalmitoylated G protein ab subunits
Chunfa Huang, Joseph A. Duncan, Alfred G. Gilman, and Susanne M. Mumby
Substrate recognition by class I lysyl-tRNA 418-423 synthetases: A molecular basis for gene displacement
Michael Ibba, Heather C. Losey, Yutaka Kawarabayasi, Hisasi Kikuchi, Shipra Bunjun, and Dieter Soll * See Commentary on page 327
Expression of the p48 xeroderma pigmentosum gene 424-428 is p53-dependent and is involved in global genomic repair
Byung Joon Hwang, James M. Ford, Philip C. Hanawalt, and Gilbert Chu
Involvement of regulatory and catalytic subunits of 429-434 phosphoinositide 3-kinase in NF-KB activation
Christophe B6raud, William J. Henzel, and Patrick A. Baeuerle
PSD-95 promotes Fyn-mediated tyrosine 435-440 phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A
Tohru Tezuka, Hisashi Umemori, Tetsu Akiyama, Shigetada Nakanishi, and Tadashi Yamamoto * See Commentary on pacge 335
The Cdc6p nucleotide-binding motif is required for 441-446 loading Mcm proteins onto chromatin
Michael Weinreich, Chun Liang, and Bruce Stillman
The enzymological basis for resistance of herpesvirus 447-452 DNA polymerase mutants to acyclovir: Relationship to the structure of a-like DNA polymerases
Lin Huang, Keiko Kumura Ishii, Harmon Zuccola, Amy M. Gehring, Charles B. C. Hwang, James Hogle, and Donald M. Coen
BIOPHYSICS
Trapping of megabase-sized DNA molecules during 453-458 agarose gel electrophoresis
Sergio Gurrieri, Steven B. Smith, and Carlos Bustamante
Intra-tRNA distance measurements for nucleocapsid 459-464 protein-dependent tRNA unwinding during priming of HIV reverse transcription
Barden Chan, Kristin Weidemaier, Wai-Tak Yip, Paul F. Barbara, and Karin Musier-Forsyth
Observation of transient disorder during myosin 465-470 subfragment-1 binding to actin by stopped-flow fluorescence and millisecond time resolution electron cryomicroscopy: Evidence that the start of the crossbridge power stroke in muscle has variable geometry
Matthew Walker, Xue-Zhong Zhang, Wei Jiang, John Trinick, and Howard D. White
Cell adhesion force microscopy 471-476 G. Sagvolden, I. Giaever, B. 0. Pettersen, and J. Feder
Kinetic evidence for an on-pathway intermediate in 477-480 the folding of cytochrome c
Yawen Bai
iv
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Evidence for microscopic, long-range hydration forces 481-486 for a hydrophobic amino acid
Alexander Pertsemlidis, Alan K. Soper, Jon M. Sorenson, and Teresa Head-Gordon
Magic angle spinning NMR of the protonated 487-492 retinylidene Schiff base nitrogen in rhodopsin: Expression of 15N-lysine- and 13C-glycine-labeled opsin in a stable cell line
Markus Eilers, Philip J. Reeves, Weiwen Ying, H. Gobind Khorana, and Steven 0. Smith
CELL BIOLOGY
A direct role for arrestins in desensitization of the 493-498 luteinizing hormone/choriogonadotropin receptor in porcine ovarian follicular membranes
Sutapa Mukherjee, Krzysztof Palczewski, Vsevolod Gurevich, Jeffrey L. Benovic, J. Paul Banga, and Mary Hunzicker-Dunn
A Gs, mutant designed to inhibit receptor signaling 499-504 through G,
Taroh liri, Sean M. Bell, Thomas J. Baranski, Toshiro Fujita, and Henry R. Bourne
Androgens regulate bone resorption activity of 505-510 isolated osteoclasts in vitro
Larry Pederson, Matthew Kremer, Jeffrey Judd, David Pascoe, Thomas C. Spelsberg, B. Lawrence Riggs, and Merry Jo Oursler
Claudin multigene family encoding 511-516 four-transmembrane domain protein components of tight junction strands
Kazumasa Morita, Mikio Furuse, Kazushi Fujimoto, and Shoichiro Tsukita * See Commentary on page 319
Moel, a conserved protein in Schizosaccharornyces 517-522 pombe, interacts with a Ras effector, Scdl, to affect proper spindle formation
Chang-rung Chen, Ying-chun Li, Jing Chen, Ming-chin Hou, Piyi Papadaki, and Eric C. Chang
DEVELOPMENTAL BIOLOGY
Synergistic activities of multiple phosphotyrosine 523-528 residues mediate full signaling from the Drosophila Torso receptor tyrosine kinase
Urte Gayko, Vaughn Cleghon, Terry Copeland, Deborah K. Morrison, and Norbert Perrimon
Characterization of otoconin-95, the major protein of 529-534 murine otoconia, provides insights into the formation of these inner ear biominerals
Elisabeth Verpy, Michel Leibovici, and Christine Petit
Groucho and dCtBP mediate separate pathways of 535-540 transcriptional repression in the Drosophila embryo
Hailan Zhang and Michael Levine
Paralogous mouse Hox genes, Hoxa9, Hoxb9, and 541-546 Hoxd9, function together to control development of the mammary gland in response to pregnancy
Feng Chen and Mario R. Capecchi * See Commentaty on page 322
Retinoid X receptors are essential for early mouse 547-551 development and placentogenesis
Olivia Wendling, Pierre Chambon, and Manuel Mark
MyoR: A muscle-restricted basic helix-loop-helix 552-557 transcription factor that antagonizes the actions of MyoD
Jianrong Lu, Robert Webb, James A. Richardson, and Eric N. Olson
Isolation and expression of a Pax-6 gene in the 558-563 regenerating and intact Planarian Dugesia(G)tigrina
P. Callaerts, A. M. Munoz-Marmol, S. Glardon, E. Castillo, H. Sun, W.-H. Li, W. J. Gehring, and E. Salo
Functional analysis of an eye specific enhancer of the 564-569 eyeless gene in Drosophila
Bernd Hauck, Walter J. Gehring, and Uwe Walldorf
ECOLOGY
Experimental demonstration that offspring sex ratio 570-573 varies with maternal condition
R. G. Nager, P. Monaghan, R. Griffiths, D. C. Houston, and R. Dawson
EVOLUTION
New estimates of the rates and effects of mildly 574-579 deleterious mutation in Drosophila melanogaster
James D. Fry, Peter D. Keightley, Stefanie L. Heinsohn, and Sergey V. Nuzhdin
Microsporidia are related to Fungi: Evidence from the 580-585 largest subunit of RNA polymerase II and other proteins
Robert P. Hirt, John M. Logsdon, Jr., Bryan Healy, Michael W. Dorey, W. Ford Doolittle, and T. Martin Embley
GENETICS
Gender-specific frequency of backgrouLnd somatic 586-591 mutations at the hypoxanthine phosphoribosyltransferase locus in cord blood T lymphocytes from preterm newborns
Makoto Yoshioka, Pamela M. Vacek, Tina Poseno, Robert Silver, and Barry A. Finette
Human artificial chromosomes generated by 592-597 modification of a yeast artificial chromosome containing both human alpha satellite and single-copy DNA sequences
Karla A. Henning, Elizabeth A. Novotny, Sheila T. Compton, Xin-Yuan Guan, Pu P. Liu, and Melissa A. Ashlock
The human LARGE gene from 22ql2.3-ql3.1 is a 598-603 new, distinct member of the glycosyltransferase gene family
Myriam Peyrard, Byal Seroussi, Ann-Christin Sandberg-Nordqvist, Ya-Gang Xie, Fei-Yu Han, Ingegerd Franisson, John Collins, Jan Dunham, Maria Kost-Alimova, Stephan Imreh, and Jan P. Dumaniski
v
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Contents Functional dissection of the transmitter module of the 604-609 histidine kinase NtrB in Escherichia coli
Gunter Kramer and Verena Weiss
Development of the arbitrarily primed- 610-615 representational difference analysis method and chromosomal mapping of isolated high throughput rat genetic markers
DNA methylation in transcriptional repression of two 616-621 differentially expressed X-linked genes, GPC3 and SYBLI
Reid Huber, R. Scott Hansen, Maria Strazzullo, Gina Pengue, Richard Mazzarella, Michele D'Urso, David Schlessinger, Giuseppe Pilia, Stanley M. Gartler, and Maurizio D'Esposito
IMMUNOLOGY
Costimulatory signals are required for induction of 622-627 transcription factor Nur77 during negative selection of CD4+CD8+ thymocytes
Derk Amsen, Conchi Revilla Calvo, Barbara A. Osborne, and Ada M. Kruisbeek
Role of decay-accelerating factor in regulating 628-633 complement activation on the erythrocyte surface as revealed by gene targeting
Xiujun Sun, Colin D. Funk, Chengjun Deng, Arvind Sahu, John D. Lambris, and Wen-Chao Song
Copolymer 1 acts against the immunodominant 634-639 epitope 82-100 of myelin basic protein by T cell receptor antagonism in addition to major histocompatibility complex blocking
Rina Aharoni, Dvora Teitelbaum, Ruth Arnon, and Michael Sela
Generation of native bovine mAbs by phage display 640-645 P. M. O'Brien, R. Aitken, B. W. O'Neil, and M. S. Campo
cDNA cloning of FRIL, a lectin from Dolichos lablab, 646-650 that preserves hematopoietic progenitors in suspension culture
Gabriella Colucci, Jeffrey G. Moore, Michael Feldman, and Maarten J. Chrispeels
Mechanisms for induction of acquired host immunity 651-656 by neutrophil peptide defensins
James W. Lillard, Jr., Prosper N. Boyaka, Oleg Chertov, Joost J. Oppenheim, and Jerry R. McGhee
MEDICAL SCIENCES
Nitric oxide synthase in cardiac sarcoplasmic reticulum 657-662 Kai Y. Xu, David L. Huso, Ted M. Dawson, David S. Bredt, and Lewis C. Becker
CXCR4 utilization is sufficient to trigger CD4+[ T cell 663-668 depletion in HI V-i-infected human lymphoid tissue
Michael L. Penn, Jean-Charles Grivel, Birgit Schramm, Mark A. Goldsmith, and Leonid Margolis
Selective induction of apoptosis by the cytotoxic 669-673 analog AN-207 in cells expressing recombinant receptor for luteinizing hormone-releasing hormone
Daniel C. Danila, Andrew V. Schally, Attila Nagy, and Joseph M. Alexander
Leptin inhibits insulin gene transcription and reverses 674-679 hyperinsulinemia in leptin-deficient ob/ob mice
Jochen Seufert, Timothy J. Kieffer, and Joel F. Habener
Expression of dominant-negative and mutant isoforms 680-685 of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia
Lei Sun, Nyla Heerema, Lisa Crotty, Xian Wu, Christopher Navara, Alexei Vassilev, Martha Sensel, Gregory H. Reaman, and Fatih M. Uckun
The plasminogen activator inhibitor-2 gene is not 686-691 required for normal murine development or survival
Kristiann M. Dougherty, Julia M. Pearson, Angela Y. Yang, Randal J. Westrick, Mark S. Baker, and David Ginsburg
Synthesis and biological evaluation of antagonists of 692-697 growth hormone-releasing hormone with high and protracted in vivo activities
J6zsef L. Varga, Andrew V. Schally, Valer J. Csernus, Marta Zarandi, Gabor Halmos, Kate Groot, and Zoltan R6kasi
Permissive role of thrombopoietin and granulocyte 698-702 colony-stimulating factor receptors in hematopoietic cell fate decisions in vivo
Ruedi Stoffel, Sandra Ziegler, Nico Ghilardi, Birgit Ledermann, Frederic J. de Sauvage, and Radek C. Skoda
Rapid production of specific vaccines for lymphoma 703-708 by expression of the tumor-derived single-chain Fv epitopes in tobacco plants
Alison A. McCormick, Monto H. Kumagai, Kathleen Hanley, Thomas H. Turpen, Itzhak Hakim, Laurence K. Grill, Daniel Tus6, Shoshana Levy, and Ronald Levy
MICROBIOLOGY
A role for RNA helicase A in post-transcriptional 709-714 regulation of HIV type 1
Junzhou Li, Hengli Tang, Tina-Marie Mullen, Christopher Westberg, Thipparthi R. Reddy, David W. Rose, and Flossie Wong-Staal
Killing of Caenorhabditis elegans by Pseudomonas 715-720 aeruginosa used to model mammalian bacterial pathogenesis
Man-Wah Tan, Shalina Mahajan-Miklos, and Frederick M. Ausubel
NEUROBIOLOGY
Purification of serine racemase: Biosynthesis of the 721-725 neuromodulator D-serine
Herman Wolosker, Kevin N. Sheth, Masaaki Takahashi, Jean-Pierre Mothet, Roscoe 0. Brady, Jr., Christopher D. Ferris, and Solomon H. Snyder
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Pseudechetoxin: A peptide blocker of cyclic 754-759 nucleotide-gated ion channels
R. Lane Brown, Tammie L. Haley, Karen A. West, and John W. Crabb
PHYSIOLOGY
Post-priming actions of ATP on Ca2-1-dependent 760-765 exocytosis in pancreatic beta cells
Noriko Takahashi, Takashi Kadowaki, Yoshio Yazaki, Graham C. R. Ellis-Davies, Yasushi Miyashita, and Haruo Kasai U See Commentaly on page 329
PLANT BIOLOGY
Involvement of specific calmodulin isoforms in 766-771 salicylic acid-independent activation of plant disease resistance responses
Won Do Heo, Sang Hyoung Lee, Min Chul Kim, Jong Cheol Kim, Woo Sik Chung, Hyun Jin Chun, Kyoung Joo Lee, Chan Young Park, Hycong Cheol Park, Ji Young Choi, and Moo Je Cho
Selectable viruses and altered susceptibility mutants in 772-777 Arabidopsis thaliania
Steven A. Whitham, Miki L. Yamamoto, and James C. Carrington
A cytochrome b5 is required for full activity of 778-783 flavonoid 3',5'-hydroxylase, a cytochrome P450 involved in the formation of blue flower colors
Nick de Vetten, Jeroen ter Horst, Henk-Peter van Schaik, Albertus de Boer, Joseph Mol, and Ronald Koes
The evolutionary origin of the protein-translocating 784-789 channel of chloroplastic envelope membranes: Identification of a cyanobacterial homolog
Sigrun Reumann, Jennifer Davila-Aponte, and Kenneth Keegstra
POPULATION BIOLOGY
The effect of antibody-dependent enhancement on the 790-794 transmission dynamics and persistence of multiple-strain pathogens
Neil Ferguson, Roy Anderson, and Sunetra Gupta
CORRECTIONS
COMMENTARY Lignification of plant cell walls: Impact of 795 genetic manipulation
Hans-Joachim G. Jung and Weiting Ni
BIOCHEMISTRY Requirement of GM2 ganglioside activator for 795 phospholipase D activation
CELL BIOLOGY Impairing follicle-stimulating hormone (FSH) 795 signaling in vivo: Targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance
Andree Dierich, M. Ram Sairam, Lucia Monaco, Gian Maria Fimia, Anne Gansmuller, Marianne LeMeur, and Paolo Sassone-Corsi
Efficient construction of a large nonimmune phage 795 antibody library: The production of high-affinity human single-chain antibodies to protein antigens
Michael D. Sheets, Peter Amersdorfer, Ricarda Finnem, Peter Sargent, Ericka Lindqvist, Robert Schier, Grete Hemingsen, Cindy Wong, John C. Gerhart, and James D. Marks
AUTHOR INDEX ix-x
INFORMATION FOR AUTHORS xi-xiii
SIZING WORKSHEET xiv
DOCUMENTATION REPORT xv
COPYRIGHT ASSIGNMENT FORM xvi
CLASSIFIED ADVERTISEMENTS xvii
Cover photograph: Petunia flower showing the color change caused by a transposon insertion in the difF gene blocking the expression of cytochrome b5. The absence of cytochrome b5 reduces the activity of a cytochrome P450 enzyme that hydroxylates precursors of anthocyanin pigments, resulting in a reddish flower color. Transposon excisions that restore cytochrome b5 expression cause the formation of dull-gray colored sectors and spots in which hydroxylation is restored. This provides direct proof that cytochrome b5 proteins stimulate the activity of specific cytochrome P450s, as described by de Vetten et al. on pages 778-783 in this issue.
vii
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