Front Matter Source: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 15 (Jul. 20, 1999), pp. i-viii Published by: National Academy of Sciences Stable URL: http://www.jstor.org/stable/48474 . Accessed: 07/05/2014 14:03 Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at . http://www.jstor.org/page/info/about/policies/terms.jsp . JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact [email protected]. . National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access to Proceedings of the National Academy of Sciences of the United States of America. http://www.jstor.org This content downloaded from 169.229.32.136 on Wed, 7 May 2014 14:03:45 PM All use subject to JSTOR Terms and Conditions
Transcript
Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 96, No. 15 (Jul. 20, 1999), pp. i-viiiPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/48474 .
Accessed: 07/05/2014 14:03
Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at .http://www.jstor.org/page/info/about/policies/terms.jsp
.JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range ofcontent in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new formsof scholarship. For more information about JSTOR, please contact [email protected].
.
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PNAS Proceedings of the National Academy of Sciences of the United States of America
July 20,1999 vol. 96 no. 15 pp. 8309-8800 www.pnas.org
Sensing kinetochore-microtubule attachment Gene therapy in plants Understanding disease pathophysiology aids gene localization Guest exchange in an encapsidation complex Gene silencing by subcellular sequestration
Frontiers of Science Symposium
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Commentaries From the Academy Frontiers of Science Symzposium
On the mechanism of silencing in Escherichia coli 8309-8311 Jasper Rine Introduction to German-American Frontiers 8327 * See companion article on page 8557 of Science
How to induce involuntary suicide: The need for 8312-8314 Ultrafast detection and control of molecular dynamics 8328-8329 dipeptidyl peptidase I Philip Anfinrud, Regina de Vivie-Riedle,
Eckhard R. Podack and Volker Engel * See companion article on page 8627
Smart materials and structures 8330-8331 A paradigm for finding genes for a complex human 8315-8317 Wenwu Cao, Harley H. Cudney, and Rainer Waser trait: Polycystic ovary syndrome and follistatin
Kunle Odunsi and Kenneth K. Kidd The mathematics of microstructure and the design of 8332-8333 * See companion article on page 8573 new materials
K. Bhattacharya, G. Friesecke, and R. D. James Here's the hook: Similar substrate binding sites in the 8318-8320 chaperone domains of Clp and Lon The past and the future fate of the universe and the 8334-8335
Sue Wickner and Michael R. Maurizi formation of structure in it * See companion article on page 6678 in issue 12 of Hans-Walter Rix volume 96
Emerging fluorescence sensing technologies: From 8336-8337 Gene therapy in plants 8321-8323 photophysical principles to cellular applications
Barbara Hohn and Holger Puchta A. Prasanna de Silva, Jens Eilers, * See companion articles on pages 8768 and 8774 and Gregor Zlokarnik
Pespective Inaugural Article
Tat as one key to HI V-induced immune pathogenesis 8324-8326 A "midinfrared" scenario for 8365-8372 and as an important component of a vaccine cuprate superconductivity
Robert C. Gallo A. J. Leggett
iii
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Resolution of concerted versus sequential mechanisms 8338-8343 in photo-induced double-proton transfer reaction in 7-azaindole H-bonded dimer
Javier Catalan, Juan Carlos del Valle, and Michael Kasha
Guest exchange in an encapsulation complex: 8344-8347 A supramolecular substitution reaction
Javier Santamaria, Tomas Martin, Goran Hilmersson, Stephen L. Craig, and Julius Rebek, Jr.
Potent selective nonpeptidic inhibitors of human 8348-8352 lung tryptase
Laurence E. Burgess, Bradley J. Newhouse, Prabha Ibrahim, James Rizzi, Mohammed A. Kashem, Ann Hartman, Barbara J. Brandhuber, Clifford D. Wright, David S. Thomson, Guy P. A. Vigers, and Kevin Koch
Long-distance charge transport in duplex DNA: The 8353-8358 phonon-assisted polaron-like hopping mechanism
Paul T. Henderson, Denise Jones, Gregory Hampikian, Yongzhi Kan, and Gary B. Schuster
MATHEMATICS
Dynamics of Helicobacter pylori colonization in 8359-8364 relation to the host response
Martin J. Blaser and Denise Kirschner
PHYSICS
A "midinfrared" scenario for 8365-8372 cuprate superconductivity
A. J. Leggett
Biological Sciences
AGRICULTURAL SCIENCES
Genetic mapping of resistance to Bacillus thuringiensis 8373-8377 toxins in diamondback moth using biphasic linkage analysis
David G. Heckel, Linda J. Gahan, Yong-Biao Liu, and Bruce E. Tabashnik
BIOCHEMISTRY
Crystal structure of the pleckstrin 8378-8383 homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1
Sirano Dhe-Paganon, Elizabeth A. Ottinger, Robert T. Nolte, Michael J. Eck, and Steven E. Shoelson
A structural snapshot of an intermediate on the 8384-8389 streptavidin-biotin dissociation pathway
Stefanie Freitag, Vano Chu, Julie E. Penzotti, Lisa A. Klumh, Richard To, David Hyre, Isolde Le Trong, Terry P. Lyhrand, Ronald B. Stenkamp, and Patrick S. Stayton
Interactions of Escherichia coli or70 within the 8390-8395 transcription elongation complex
Shirley S. Dauhe and Peter H. von Hippel
Crystal structure of ERA: A GTPase-dependent cell 8396-8401 cycle regulator containing an RNA binding motif
Xin Chen, Donald L. Court, and Xinhua Ji
A novel function for transglutaminase 1: Attachment 8402-8407 of long-chain w-hydroxyceramides to involucrin by ester bond formation
Zoltan Nemes, Lyuben N. Marekov, Lazl6 Fesis, and Peter M. Steinert
Crystallographic analysis of CD40 recognition and 8408-8413 signaling by human TRAF2
Sarah M. McWhirter, Steven S. Pullen, James M. Holton, James J. Crute, Marilyn R. Kehry, and Tom Alber
A model for the mechanism of strand passage by 8414-8419 DNA gyrase
Sotirios C. Kampranis, Andrew D. Bates, and Anthony Maxwell
Three-dimensional structure of low density 8420-8425 lipoproteins by electron cryomicroscopy
Elena V. Orlova, Michael B. Sherman, Wah Chiu, Hiro Mowri, Louis C. Smith, and Antonio M. Gotto, Jr.
Protein preservation and DNA retrieval from 8426-8431 ancient tissues
Hendrik N. Poinar and B. Artur Stankiewicz
A role for coenzyme M (2-mercaptoethanesulfonic 8432-8437 acid) in a bacterial pathway of aliphatic epoxide carboxylation
Jeffrey R. Allen, Daniel D. Clark, Jonathan G. Krum, and Scott A. Ensign
Hot-spot mutants of p53 core domain evince 8438-8442 characteristic local structural changes
Kam-Bo Wong, Brian S. DeDecker, Stefan M. V. Freund, Mark R. Proctor, Mark Bycroft, and Alan R. Fersht
Cell cycle regulation of Dfpl, an activator of the Hskl 8443-8448 protein kinase
Grant W. Brown and Thomas J. Kelly
Human papillomavirus type 31 oncoproteins E6 and 8449-8454 E7 are required for the maintenance of episomes during the viral life cycle in normal human keratinocytes
Jennifer T. Thomas, Walter G. Hubert, Margaret N. Ruesch, and Laimonis A. Laimins
The kinetoplast structure-specific endonuclease I is 8455-8460 related to the 5' exo/endonuclease domain of bacterial DNA polymerase I and colocalizes with the kinetoplast topoisomerase II and DNA polymerase 13 during replication
Michele L. Engel and Dan S. Ray
Gene silencing via protein-mediated subcellular 8557-8561 localization of DNA
Sook-Kyung Kim and James C. Wang * See Commentary on page 8309
BIOPHYSICS
Characterization of lipid bilayer phases by confocal 8461-8466 microscopy and fluorescence correlation spectroscopy
Jonas Korlach, Petra Schwille, Watt W. Webb, and Gerald W. Feigenson
iv
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Contents Translocation of the catalytic domain of diphtheria 8467-8470 toxin across planar phospholipid bilayers by its own T domain
Kyoung Joon Oh, Lisa Senzel, R. John Collier, and Alan Finkelstein
Mapping the sensitivity of T cells with an optical trap: 8471-8476 Polarity and minimal number of receptors for Ca2+ signaling
Xunbin Wei, Bruce J. Tromberg, and Michael D. Cahalan
A systematic study of low-resolution recognition in 8477-8482 protein-protein complexes
Ilya A. Vakser, Omar G. Matar, and Chan F. Lam
CELL BIOLOGY
Development of gene-switch transgenic mice that 8483-8488 inducibly express transforming growth factor 11 in the epidermis
Xiao-Jing Wang, Kristin M. Liefer, Sophia Tsai, Bert W. O'Malley, and Dennis R. Roop
The tumor-suppressor gene FHIT is involved in the 8489-8492 regulation of apoptosis and in cell cycle control
Laura Sard, Paola Accornero, Silvana Tornielli, Domenico Delia, Giuseppe Bunone, Manuela Campiglio, Mario P. Colombo, Marcella Gramegna, Carlo M. Croce, Marco A. Pierotti, and Gabriella Sozzi
Retention of the Bub3 checkpoint protein on 8493-8498 lagging chromosomes
Maria J. Martinez-Exposito, Kenneth B. Kaplan, Jay Copeland, and Peter K. Sorger
TID1, a human homolog of the Drosophila tumor 8499-8504 suppressor 1(2)tid, encodes two mitochondrial modulators of apoptosis with opposing functions
Josh Syken, Tali De-Medina, and Karl Munger
Mammalian unfolded protein response inhibits cyclin 8505-8510 DI translation and cell-cycle progression
Joseph W. Brewer, Linda M. Hendershot, Charles J. Sherr, and J. Alan Diehl
Suppression of apoptosis signal-regulating kinase 8511-8515 1-induced cell death by 14-3-3 proteins
Lixin Zhang, Jing Chen, and Haian Fu
The cytosolic tail of class I MHC heavy chain is 8516-8521 required for its dislocation by the human cytomegalovirus US2 and US1I gene products
Craig M. Story, Margo H. Furman, and Hidde L. Ploegh
Hsl7p, a negative regulator of Ste20p protein kinase 8522-8527 in the Saccharomyces cerevisiae filamentous growth-signaling pathway
Genetic evidence that Shp-2 tyrosine phosphatase is a 8528-8533 signal enhancer of the epidermal growth factor receptor in mammals
Cheng-Kui Qu, Wen-Mei Yu, Biagio Azzarelli, and Gen-Sheng Feng
ECOLOGY
Natural 13C abundance reveals trophic status of fungi 8534-8539 and host-origin of carbon in mycorrhizal fungi in mixed forests
Peter H6gberg, Agneta H. Plamboeck, Andrew F. S. Taylor, and Petra M. A. Fransson
EVOLUTION
Divergent evolution of membrane protein topology: 8540-8544 The Escherichia coli RnfA and RnfE homologues
Annika Saaf, Marie Johansson, Erik Wallin, and Gunnar von Heijne
Transcription in Archaea 8545-8550 Nikos C. Kyrpides and Christos A. Ouzounis
GENETICS
The magical touch: Genome targeting in epidermal 8551-8556 stem cells induced by tamoxifen application to mouse skin
Valeri Vasioukhin, Linda Degenstein, Bart Wise, and Elaine Fuchs
Gene silencing via protein-mediated subcellular 8557-8561 localization of DNA
Sook-Kyung Kim and James C. Wang
Mucolipidosis IV consists of one complementation group 8562-8566 Ehud Goldin, Adele Cooney, Christine R. Kaneski, Roscoe 0. Brady, and Raphael Schiffmann
"Mutagenesis" by peptide aptamers identifies genetic 8567-8572 network members and pathway connections
C. Ronald Geyer, Alejandro Colman-Lerner, and Roger Brent
Thirty-seven candidate genes for polycystic ovary 8573-8578 syndrome: Strongest evidence for linkage is with follistatin
Margrit Urbanek, Richard S. Legro, Deborah A. Driscoll, Ricardo Azziz, David A. Ehrmann, Robert J. Norman, Jerome F. Strauss, III, Richard S. Spielman, and Andrea Dunaif * See Commentary on page 8315
An agouti mutation lacking the basic domain induces 8579-8584 yellow pigmentation but not obesity in transgenic mice
R. J. Miltenberger, R. L. Mynatt, B. D. Bruce, W. 0. Wilkison, R. P. Woychik, and E. J. Michaud
IMMUNOLOGY
Stromal cell-derived factor 1 (SDF-1) and antenatal 8585-8590 human B cell lymphopoiesis: Expression of SDF-1 by mesothelial cells and biliary ductal plate epithelial cells
Aurore Coulomb-L'Hermin6, Ali Amara, Claudine Schiff, Ingrid Durand-Gasselin, Arnaud Foussat, Thierry Delaunay, G6rard Chaouat, Fr6d6rique Capron, Nathalie Ledee, Pierre Galanaud, Fernando Arenzana-Seisdedos, and Dominique Emilie
Tumor-targeted IL-2 amplifies T cell-mediated 8591-8596 immune response induced by gene therapy with single-chain IL-12
Holger N. Lode, Rong Xiang, Steven R. Duncan, Argyrios N. Theofilopoulos, Stephen D. Gillies, and Ralph A. Reisfeld
v
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In vivo proliferation of naive and memory 8597-8602 inf luenza-specific CD8 + T cells
Kirsten J. Flynn, Janice M. Riberdy, Jan P. Christensen, John D. Altman, and Peter C. Doherty
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates 8603-8608 primary and secondary peptide-specific CD4+ T cell responses
Cynthia A. Chambers, Michael S. Kuhns, and James P. Allison
Induction of hyporesponsiveness to intact foreign 8609-8614 protein via retroviral-mediated gene expression: The IgG scaffold is important for induction and maintenance of immune hyporesponsiveness
Yubin Kang, Marco Melo, Edward Deng, Roland Tisch, Moustapha El-Amine, and David W. Scott
One Lyn molecule is sufficient to initiate 8615-8620 phosphorylation of aggregated high-affinity IgE receptors
Carla Wofsy, Becky M. Vonakis, Henry Metzger, and Byron Goldstein
The lack of consensus for I-Ag7-peptide binding 8621-8626 motifs: Is there a requirement for anchor amino acid side chains?
Eugenio Carrasco-Marin, Osami Kanagawa, and Emil R. Unanue
Dipeptidyl peptidase I is required for the processing 8627-8632 and activation of granzymes A and B in vivo
Christine T. N. Pham and Timothy J. Ley * See Commentary on page 8312
CD4+ T cells eliminate MHC class 11-negative cancer 8633-8638 cells in vivo by indirect effects of IFN--y
Dominik Mumberg, Paul A. Monach, Sherry Wanderling, Mary Philip, Alicia Y. Toledano, Robert D. Schreiber, and Hans Schreiber
MEDICAL SCIENCES
Potent selective nonpeptidic inhibitors of human 8348-8352 lung tryptase
Laurence E. Burgess, Bradley J. Newhouse, Prabha Ibrahim, James Rizzi, Mohammed A. Kashem, Ann Hartman, Barbara J. Brandhuber, Clifford D. Wright, David S. Thomson, Guy P. A. Vigers, and Kevin Koch
CD8+ minor histocompatibility antigen-specific 8639-8644 cytotoxic T lymphocyte clones eliminate human acute myeloid leukemia stem cells
Dominique Bonnet, Edus H. Warren, Philip D. Greenberg, John E. Dick, and Stanley R. Riddell
Defective CTLA-4 cycling pathway in 8645-8650 Chediak-Higashi syndrome: A possible mechanism for deregulation of T lymphocyte activation
Franck J. Barrat, Francoise Le Deist, Malika Benkerrou, Philippe Bousso, Jerome Feldmann, Alain Fischer, and Genevieve de Saint Basile
Elevated retinoic acid receptor 14 protein in human 8651-8656 breast tumor cells with nuclear and cytoplasmic localization
Karen M. Sommer, Lucinda I. Chen, Piper M. Treuting, Lynne T. Smith, and Karen Swisshelm
Long-term regulated expression of growth hormone in 8657-8662 mice after intramuscular gene transfer
Victor M. Rivera, Xuehai Ye, Nancy L. Courage, Jeff Sachar, Frank Cerasoli, Jr., James M. Wilson, and Michael Gilman
Regulation of vascular endothelial growth factor 8663-8668 production and angiogenesis by the cytoplasmic tail of tissue factor
Keisuke Abe, Mamoru Shoji, Jiang Chen, Angelika Bierhaus, Indrani Danave, Cornelia Micko, Katherine Casper, Dirck L. Dillehay, Peter P. Nawroth, and Frederick R. Rickles
Medin: An integral fragment of aortic smooth muscle 8669-8674 cell-produced lactadherin forms the most common human amyloid
Bo Haggqvist, Jan Naslund, Knut Sletten, Gunilla T. Westermark, Gerd Mucchiano, Lars 0. Tjernberg, Christer Nordstedt, Ulla Engstr6m, and Per Westermark
JE-2147: A dipeptide protease inhibitor (PI) that 8675-8680 potently inhibits multi-PI-resistant HIV-1
Kazuhisa Yoshimura, Ryohei Kato, Keisuke Yusa, Mark F. Kavlick, Victor Maroun, Aline Nguyen, Tsutomu Mimoto, Takamasa Ueno, Makoto Shintani, Judith Falloon, Henry Masur, Hideya Hayashi, John Erickson, and Hiroaki Mitsuya
CpG island methylator phenotype in colorectal cancer 8681-8686 Minoru Toyota, Nita Ahuja, Mutsumi Ohe-Toyota, James G. Herman, Stephen B. Baylin, and Jean-Pierre J. Issa
Transient expression of DNA and RNA in parasitic 8687-8692 helminths by using particle bombardment
Richard E. Davis, Angelica Parra, Philip T. LoVerde, Eugenia Ribeiro, Gina Glorioso, and Scott Hodgson
A heterozygous mutation of 3-actin associated with 8693-8698 neutrophil dysfunction and recurrent infection
Hiroyuki Nunoi, Tsuyoshi Yamazaki, Hiroyuki Tsuchiya, Seishi Kato, Harry L. Malech, Ichiro Matsuda, and Shiro Kanegasaki
Herpes simplex virus thymidine kinase/ganciclovir- 8699-8704 induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases
Christian Beltinger, Simone Fulda, Thomas Kammertoens, Eric Meyer, Wolfgang Uckert, and Klaus-Michael Debatin
Negative cross-talk between hematopoietic regulators: 8705-8710 GATA proteins repress PU.1
Pu Zhang, Gerhard Behre, Jing Pan, Atsushi Iwama, Nawarat Wara-aswapati, Hanna S. Radomska, Philip E. Auron, Daniel G. Tenen, and Zijie Sun
Cancer dormancy and cell signaling: Induction of 8711-8715 p2lwafl initiated by membrane IgM engagement increases survival of B lymphoma cells
Radu Marches, Robert Hsueh, and Jonathan W. Uhr
MICROBIOLOGY
Dynamics of Helicobacter pylori colonization in 8359-8364 relation to the host response
Martin J. Blaser and Denise Kirschner
vi
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Contents A set of independent selectable markers for 8716-8720 transfection of the human malaria parasite Plasmodium falciparun
Choukri Ben Mamoun, Ilya Y. Gluzman, Sophie Goyard, Stephen M. Beverley, and Daniel E. Goldberg
NEUROBIOLOGY
Differential acute and chronic responses of tumor 8721-8726 necrosis factor-deficient mice to experimental brain injury
Uwe Scherbel, Ramesh Raghupathi, Michio Nakamura, Kathryn E. Saatman, John Q. Trojanowski, Edmund Neugebauer, Michael W. Marino, and Tracy K. McIntosh
Transgenic mice expressing a Huntington's disease 8727-8732 mutation are resistant to quinolinic acid-induced striatal excitotoxicity
Oskar Hansson, Asa Peters6n, Marcel Leist, Pierluigi Nicotera, Roger F. Castilho, and Patrik Brundin
Inhibition of uptake unmasks rapid extracellular 8733-8738 turnover of glutamate of nonvesicular origin
D. Jabaudon, K. Shimamoto, Y. Yasuda-Kamatani, M. Scanziani, B. H. Gahwiler, and U. Gerber
Novelty acquisition is associated with induction of 8739-8744 hippocampal long-term depression
Denise Manahan-Vaughan and Karl-Heinz Braunewell
Lithium activates the serine/threonine kinase Akt-1 8745-8750 and suppresses glutamate-induced inhibition of Akt-I activity in neurons
Elzbieta Chalecka-Franaszek and De-Maw Chuang
Cross-modal reorganization of callosal connectivity 8751-8756 without altering thalamocortical projections
Sarah L. Pallas, Thomas Littman, and David R. Moore
PHYSIOLOGY
Intravascular flow decreases erythrocyte consumption 8757-8761 of nitric oxide
James C. Liao, Travis W. Hein, Mark W. Vaughn, Kuang-Tse Huang, and Lih Kuo
PLANT BIOLOGY
The violaxanthin cycle protects plants from 8762-8767 photooxidative damage by more than one mechanism
Michel Havaux and Krishna K. Niyogi
Targeted manipulation of maize genes in vivo using 8768-8773 chimneric RNA/DNA oligonucleotides
Tong Zhu, David J. Peterson, Laura Tagliani, Grace St. Clair, Chris L. Baszczynski, and Ben Bowen U See Commentary on page 8321
A tool for functional plant genomics: Chimeric 8774-8778 RNA/DNA oligonucleotides cause in vivo gene-specific mutations
Peter R. Beetham, Peter B. Kipp, Xenia L. Sawycky, Charles J. Arntzen, and Gregory D. May * See Commentary on page 8321
LOV (light, oxygen, or voltage) domains of the 8779-8783 blue-light photoreceptor phototropin (nphl): Binding sites for the chromophore flavin mononucleotide
John M. Christie, Michael Salomon, Kazunari Nozue, Masamitsu Wada, and Winslow R. Briggs
Algae displaying the diadinoxanthin cycle also possess 8784-8789 the violaxanthin cycle
Martin Lohr and Christian Wilhelm
PSYCHOLOGY
How can we boost lQs of "dull children"?: A late 8790-8794 adoption study
Michel Duyme, Annick-Camille Dumaret, and Stanislaw Tomkiewicz
Social Sciences
ANTHROPOLOGY
Oreopithecus was a bipedal ape after all: 8795-8799 Evidence from the iliac cancellous architecture
Lorenzo Rook, Luca Bondioli, Meike Kdhler, Salvador Moya-So1, and Roberto Macchiarelli
CORRECTIONS
FROM THE ACADEMY List of New Members 8800
APPLIED BIOLOGICAL SCIENCES Regulation of the zinc transporter ZnT-1 by dietary zinc 8800
Robert J. McMahon and Robert J. Cousins
AUTHOR INDEX ix-x
INFORMATION FOR AUTHORS xi-xiii
SIZING WORKSHEET xiv
DOCUMENTATION REPORT xv
COPYRIGHT ASSIGNMENT FORM xvi
SUBSCRIPTION FORM xvii
CLASSIFIED ADVERTISEMENT xix
Cover photograph: A HeLa cell at the metaphase stage of mitosis, with the mitotic spindle in red and the chromosomes in blue. Treatment of the cell with taxol results in chromosomes that fail to properly attach to the mitotic spindle and accumulate high levels of Bub3 protein at the chromosome spindle attachment point (two green dots, lower left). In contrast, levels of Bub3 are reduced on chromosomes that have successfully aligned on the spindle. This result supports the idea that Bub3 specifically monitors attachment of the chromosomes to the spindle. See article by Martinez-Exposito et al. on pages 8493-8498.
vii
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