Front Matter

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JANUARY 1977

VOLUME 74

NUMBER I

PROC)CEEDINGS OF THE

N ationa Ac)ademy of Science OF wIH NTDSAI S OF_Y AMERIC



THE PROCEEDINGS OF THE

Natlonal Academy of Sciences OF THE UNITED STATES OF AMERICA

Officers PHILIP HANDLER President of the SAtJNDERS MAC LANE Vice President Academy DAVID R. GODDARD Home Secretary

GEORGE S. HAMMOND Foreign Secretary E. R. PIORE Treasurer

Editorial Board ROBERT L. SINSHEIMER Chairman of the ROBERT M. SOLOW Vice Chairman Proceedings HARRISON SHULL Vice Chairman

DAVID R. GODDARD Home Secretary GEORGE S. HAMMOND Foreign Secretary E. R. PIORE Treasurer

ALEXANDER G. BEARN P. D. BOYER HARRY EAGLE HERMAN EISEN

RiCHARD M. HELD MARTIN D. KAMEN HENRY S. KAPLAN SEYMOUR S. KETY

S. M. LIPSET MACLYN MCCARTY EUGENE P. ODUM ALEXANDER RicH E. R. STADTMAN ELIAS M. STEIN HOWARD M. TEMIN JAMES TOBIN

Managing Editor: BERNARD K. FORSCHER Associate Managing Editor: FRANKLIN H. PORTUGAL Assistant Managing Editor GARY T. COCKS Adjunct Associate Managing Editor MURRIE W. BURGAN

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INFORMATION TO CONTRIBUTORS

(Revised 1977) Purpose and scope

The Proceedings of the National Academy of Sciences USA publishes reports that describe the results of original theoretical or experimental research of exceptional importance or novelty. Reports are accepted only if contributed by a member of the Academy or communicated by an Academy member on behalf of a nonmember and have not been submitted for publication or previously published elsewhere.

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41 (Medical Genetics, Hematology, and Oncology), 42 (Medical Physiology, Endocrinology, and Metabolism), and 43 (Infectious Diseases and Immunology) are all listed as Medical Sciences; and Section 27 (Population Biology, Evolution, and Ecology) may be listed as Population Biology, Evolution, or Ecology. Additional headings that may be used but that are not Academy Sections are Biophysics, Immunology, Microbiology, and Sta- tistics.

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Journal articles are cited as follows: 10. Smith, A. B., Jones, C. D. & Robinson, E. F. (1969)

"Ribosome conformation," Proc. Natl. Acad. Sci. USA 64, 191-195.

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in Protozoa, eds. Smith, T. G. & Williams, H. I. (Universal Press, New Brunswick, N.J.), Vol. 21, pp. 646-672.

Authors are responsible for the accuracy of the citations. Tables. Tables should be prepared so that they are self-

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figure. It is particularly important that nomenclature, abbreviations, and units used in figures agree precisely with those used in the text of the paper. For electron micrographs and similar illustrative materials, authors should note that the quality of reproduction cannot exceed the quality of the submitted material. Do not mount illustrations unless a composite figure is required. Indicate the magnification of photomicrographs in the legend or include a bar in the figure to indicate the scale (or both).

Nomenclature. International standards on nomenclature should be used. The following guiides are recommended:

Mathematics. A Manual for Authors of Mathematical Pa- pers (1970). American Mathematical Society, 321 South Main Street, P.O. Box 6248, Providence, R.I. 02904.

Notations that are expensive to typeset should be avoided.

Provide a list of special characters used in the paper for the printer, and identify Greek, Hebrew, or script letters in the margin at the line where they first appear.

Physics. Style Manual for Guidance in the Preparation of Papers Published by the American Institute of Physics (1969). American Institute of Physics, 5 East 45th Street, New York, N.Y. 10017.

Chemistry. Handbook for Authors of Papers in the Journals of the American Chemical Society (1967). American Chemical Society Publications, 1155 16th Street, N.W., Washington, D.C. 20036.

Psychology. Publication Manual of the American Psycho- logical Association (1967). American Psychological Association, 1200 17th Street, N.W., Washington, D.C. 20036.

Life Sciences. Council of Biology Editors Style Manual

Some Standard Abbreviations

absorbance' A acetate OAc acetyl Ac N-acetylglucosamine GlcNAc adenine Ade adenosinel),e A, Ado alanine'l Ala arginine'l Arg asparagine'l Asn asparagine or aspartic acidd Asx aspartic acid'1 Asp 5-bromodeoxyuridinec BrdUrd carbon monoxide hemoglobin HbCO carbon monoxide myoglobin MbCO O-carboxymethylcellulose CM-cellulose coenzyme A CoA complementary DNA cDNA counts per minute cpm cysteine or 1/2 cystined Cys cytidinebc C, Cyd cytosine Cyt deoxy (carbohydrates and nucleic acids) d deoxyribonuclease DNase deoxyribonucleic acid DNA diethylaminoethylcellulose DEAE-cellulose diphosphopyridine nucleotide DPN+, DPNH direct current d'c flavin-adenine dinucleotide FAD flavin mononucleotide FMN formylmethionine'l fMet fructose Fru fucose Fuc galactosamine GalN galactose Gal gluconic acid GlcA glucosamine GlcN glucose" G, Glc glucuronic acid GlcUA glutamic acid'l Glu glutamic acid or glutamined Glx glutaminedi Gln glycine"l Gly guanine Gua guanosinebdc G, Guo

a Use absorbance, A, for light absorption by solutions; use optical density, OD, for light transmission through turbid suspensions.

b The 5' mono-, di-, and triphosphate derivatives are abbreviated as AMP, ADP, ATP; other nucleoside 5'-phosphates are abbreviated similarly. cAMP (adenosine 3':5'-cyclic monophosphate) and cGMP (guanosine 3':5'-cyclic monophosphate) are not considered standard.

c Similarly abbreviate other substituted purines, pyrimidines, and nucleosides.

d Use only in sequence descriptions, tables, or figures.

hemoglobin Hb histidineli His immunoglobulin Ig (IgG, IgM, etc.) inosinel)b I, no isoleucine'1 Ile isotopest 14C, 3H, 32P leucine'l Leu lysinell Lys mannose Man messenger RNA mRNA methionine"l Met mitochondrial DNA mtDNA myoglobin Mb nicotinamide-adenine dinucleotide NAD+, NADH nicotinamide-adenine dinucleotide

phosphate NADP+, NADPH nicotinamide mononucleotide NMN nucleoside (unknown)b)C N, Nuc optical densitya OD oxyhemoglobin HbO2 phenylalanine'l Phe phosphate (in compounds) P or p phosphate (inorganic) Pi poly(adenylic acid)9 poly(A) prolinetl Pro rhesus factor Rh ribonuclease RNase ribonucleic acid RNA ribose Rib ribosomal ribonucleic acid rRNA ribosylthymine T or Thd serine"l Ser threoninel Thr thymidine (2'-deoxyribosylthymine)IW ' dT or dThd thymine Thy transfer RNA tRNA triphosphopyridine nucleotide TPN, TPNH trvptophan(l Trp tyrosinel' Tyr ultraviolet UV uracil Ura uridinet U, Urd valine'l Val

eUse three-letter abbreviation when single letter is ambiguous. f The mass number is written as a superior prefix: 14C, not C14. En-

close the isotope symbol in square brackets immediately before the name or abbreviation of the compound: [32P]CMP; [14C]urea; [1- "4Cileucine; L-[methyl-14C]methionine; [1 -14C]glucose. Do not use brackets if atom does not occur naturally in the compound or if isotope is not used in a specific sense. Examples are [125I]thyroxine but 1251- labeled trypsin; [U-3H]arginine but 3H-labeled amino acids. With chemical formulas, use without brackets as '4CO2, H2"5SO4.

g Similarly abbreviate oligo- and polynucleotides containing the purine and pyrimidine bases listed in this table.

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(1972), 3rd ed. American Institute of Biological Sciences, 1401 Wilson Boulevard, Arlington, Va. 22209. Collected Tentative Rules & Recommendations of the Commission on Biochemical Nomenclature IUPAC-IUB and Related Documents (1975), 2nd ed. American Society of Biological Chemists, Inc., 9650 Rockville Pike, Bethesda, Md. 20014.

The second Life Sciences reference contains the Interna- tional Union of Biochemistry rules of nomenclature for amino acids, peptides, nucleic acids, polynucleotides, vitamins, coenzymes, quinones, folic acid and related compounds, cor- rinoids, lipids, enzymes, proteins, cyclitols, steroids, carbohydrates, carotenoids, peptide hormones, and human immunoglobulins.

Enzymes should be given the recommended name followed by the systematic name and Enzyme Commission (EC) number on first mention, both in the abstract and text. For guidance refer to: Enzyme Nomenclature: Recommendations (1972) of the International Union of Pure and Applied Chemistry and the International Union of Biochemistry (1975). Ameri- can Elsevier Publishing Co., Inc., 52 Vanderbilt Avenue, New York, N.Y. 10017. See also Supplement 1: Corrections and Additions (1975).

Genetics. A guide to nomenclature in bacterial genetics may be found in: Demerec, M., Adelberg, E. A., Clark, A. J. &

Hartman, P. E. (1966) Genetics 54, 61-76. Note that genotypes are italicized (underlined in typed copy); phenotypes are not.

Immunology. For human immunoglobulins and their genetic factors use the rules of the World Health Organization or the reference for Life Sciences above.

Abbreviations and Symbols. The PROCEEDINGS distin- guishes between standard and nonstandard abbreviations. Standard abbreviations for certain substances and units of measure listed here do not need to be defined. Most, if not all, other abbreviations are considered to be nonstandard, should be kept to a minimum, and must be spelled out on first usage. Nonstandard abbreviations should be used only for terms mentioned five or more times in the paper (for such cases, see information about Title Page).

Nonstandard abbreviations should be unambiguous, and should not simply be acronyms. Both standard and nonstandard abbreviations should also conform to international standards as set forth above. Authors should refer to: IUPAC Manual of Symbols and Terminology for Physiochemical Quantities and Units (1970) Butterworths, London, England; National Bureau of Standards Special Publication 330 (1974), eds. Page, C. H. & Vigoureux, P. (United States Government Printing Office); or Pure and Applied Chemistry (1970) 21, 3-44.

Abbreviations for Units of Measurement and of Physical and Chemical Quantities

Prefixes to the Names of Units exa 1018 E milli 10-3 m peta 1015 p micro 10-6 tera 1012 T nano 10-9 n giga 109 G pico 10-12 p mega 106 M femto 10-l5 f kilo 103 k atto 10-18 a centi 10-2 c

Units of Concentration* molar (mol/liter) M parts per million ppm

Units of Length meter m micrometer (not micron) gm (not ,u) nanometer nm (not m,u) angstrom (0.1 nm) A

Units of Volumet milliliter ml microliter tll (not X)

Units of Mass gram g microgram ,Mg (not y)

Units of Time hour hr minute min second s, sec

Units of Electricity ampere amp milliampere mA volt V ohm

The PROCEEDINGS uses units that are part of the Systeme Interna- tional (SI). When such units are not used, the SI equivalent should be given in parentheses where first mentioned.

Units of Energy and Work joule J calorie cal

Units of Temperature degree centigrade or Celsius ? thermodynamic temperature (kelvin) K

Units of Radioactivity counts per minute cpm curie(s) Ci

Miscellaneous Units revolutions per minute rpm Svedberg unit of sedimentation

coefficient (10-13 s) S cycles per second (hertz) Hz pascal (newton/meter2) Pa lux lx candela cd lumen lm

Physical and Chemical Quantities retardation factor RF acceleration of gravity g partial specific volume v refractive index n

specific rotation [aIc

sedimentation coefficient s diffusion coefficient (usually given in cm2 s-') D equilibrium constant K Michaelis constant Km molecular weight Mr

Other Words standard deviation of series SD standard error of mean SEM probability P

* For units of concentration based oii molecular weight, the mole is used. Weight concentrations should be given as g/ml, g/liter, ppm etc.; mg% is not acceptable.

t Liter should not be abbreviated unless used with a prefix.

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A UTHOR INDEX, JANUAR Y 1977

Adelstein, R. S. 129 Adler, J. 183 Allmann, H. 84 Alvarez, R. 92 Armstrong, V. W. 392 Aulakh, G. S. 353 Azumi, J.-I. 253 Barchi, R. L. 34 Bardwell, E. 291 Baserga, R. 69 Battula, N. 281 Becker, J. E. 234 Bender, M. L. 23 Benson, A. M. 158 Bertsch, L. L. 193 Beychok, S. 64 Biddison, W. E. 329 Bombik, B. M. 69 Bonilla, E. 34 Bonner, J. T. 268 Bookchin, R. M. 203 Boon, T. 272 Bouck, N. 238 Brady, R. 0. 74 Brewer, H. B., Jr. 74 Bruno, J. J. 92 Butcher, F. R. 234 Campbell, R. 258 Canaani, E. 29 Carbon, J. 49 Cardinale, G. J. 360 Chacko, S. 129 Chedid, L. 339 Chen, F. 1 Collman, J. P. 18 Conti, M. A. 129 Corden, J. 79 Croce, C. M. 315 Cusan, L. 358 Damais, C. 339 Daniele, R. P. 392 Darszon, A. 207 Davis, C. G. 263 de Crombrugghe, B. 106 DeFronzo, R. 348 Delmotte, F. M. 168 Demetrius, L. 384 Denny, S. E. 101 Detjen, B. M. 59 Diamond, I. 263 Di Lauro, R. 106 DiMayorca, G. 238 Dina, D. 29 Doherty, P. C. 334 Duesberg, P. 29 Duffin, R. J. 26 Dupont, A. 358 Eckstein, F. 392 Eisenberg, S. 193 Elbaum, D. 203 Elliott, C. M. 18 Etlinger, J. D. 54 Eyring, H. 10 Felig, P. 348 Fietzek, P. P. 84 Fishman, P. H. 74

Fournier, R. E. K. 319 Fresen, K.-O. 363 Fried, J. 248 Frisch, R. E. 379 Gallo, R. C. 353 Garon, M. 358 Gibson, R. E. 139 Gillam, S. 96 Gisin, B. F. 115 Goldberg, A. L. 54 Gordon, A. S. 263 Gordy, W. 216 Goy, M. F. 183 Gupta, P. 372 Hadley, J. H., Jr. 216 Halbert, T. R. 18 Hall, J. E. 115 Harrington, J. P. 203 Hartl, D. L. 324 Hay, E. D. 39 Hayaishi, 0. 144 Hayashi, M. 144 Heed, W. B. 387 Hegsted, D. M. 379 Hendler, R. 348 Hindman, J. C. 5 Hochhauser, S. 154 Holian, S. K. 392 Hopfield, J. J. 229 Horn, V. 286 Howard-Flanders, P. 291 Huang, C.-H. 69 Huebner, R. 343 Ihle, J. N. 343 Isakson, P. C. 101 Iwatsuki, K. 360 Jacobsberg, L. B. 111 Jahnke, P. 96 Jain, S. C. 188 Jakoby, W. B. 158 Jansing, R. L. 173 Jhon, M. S. Kane, J. P. 276 Kantrowitz, E. R. 111 Karnovsky, M. J. 258 Katz, J. J. 5 Kauzmann, W. 1 Keen, J. H. 158 Kellermann, 0. 272 Kieda, C. M. T. 168 Kobayashi, S. 115 Komiyama, M. 23 Koprowski, H. 334 Kornberg, A. 193 Kovacic, R. T. 79 Kriegstein, A. R. 375 Kugel, R. 5 Kwan, S.-P. 178 Labat, M.-L. 339 Labrie, F. 358 Landfear, S. M. 11 Lebeurier, G. 149 Lee, J. C. 343 Lee, N. 49 Lee, S. G. 163 Lee, S.-H. 10

Lee, Y. F. 59 Lehman, I. R. 154 Lennarz, W. J. 134 Leong, J. C. 276 Levin, S. A. 139 Levy, J. A. 276 Li, C. H. 358 Li, S. S.-L. 286 Lin, P.-F. 291 Lingrel, J. B. 178 Linsenmayer, T. F. 39 Lipmann, F. 163 Lipscomb, W. N. 111 Lohr, D. 79 Macnab, R. M. 221 Manning, J. M. 367 Marks, P. A. 248 Milhaud, G. 339 Mishra, N. 238 Miyake, H. 144 Mockrin, S. C. 392 Monsigny, M. L. P. 168 Montal, M. 207 Moss, J. 74 Mount, D. W. 300 Musso, R. 106 Nagel, R. L. 203 Navon, G. 87 Needleman, P. 101 Newton, A. 124 Nicolaieff, A. 149 Nigen, A. M. 367 Nomoto, A. 59 Nudel, U. 248 Nyman, P.-O. 154 Ogawa, S. 87 Ogino, N. 144 Ogunmola, G. B. 1 Ohki, S. 144 Oleszko, 0. 276 Osborne, J. C., Jr. 74 Osley, M. A. 124 Palmer, J. C. 329 Parant, M. 339 Pariza, M. W. 234 Parker, C. S. 44 Pastan, I. 243 Pethig, R. 226 Pless, D. D. 134 Potasek, M. J. 229 Potter, V. R. 234 Pouyssegur, J. 243 Pure, E. 101 Rapp, F. 372 Rauterberg, J. 84 Raz, A. 101 Regan, J. D. 238 Richards, K. E. 149 Rifkind, R. A. 248 Ritchie, J. M. 211 Rockwood-Sluss, E. S. 387 Roeder, R. G. 44 Roesel, T. R. 23 Rogart, R. B. 211 Rosenberg, M. 106 Rottman, F. 96

Rowe, J. 286 Rubenstein, P. A. 120 Ruddle, F. H. 319 Sachs, L. 253 Sakore, T. D. 188 Scandalios, J. G. 310 Scheraga, H. A. 13 Scott, J. F. 193 Seto, H. 296 Sherwin, R. S. 348 Shulman, R. G. 87 Singh, A. 305 Smith, G. N., Jr. 39 Smith, M. 96 Sobell, H. M. 188 Sorenson, J. C. 310 Spector, S. 360 Springer, M. S. 183 Spudich, J. A. 120, 392 Starmer, W. T. 387 Stein, G. S. 173 Stein, J. L. 173 Sternbach, H. 392 Sternfeld, J. 268 Sternfield, J. 268 Stone, P. J. 198 Svirmickas, A. 5 Szent-Gyorgyi, A. 226 Talalay, P. 158 Tatchell, K. 79 Temin, H. M. 281 Terada, M. 248 Thompson, R. C. 198 Tomasz, A. 296 Tovrog, B. S. 18 Trissl, H.-W. 207 Tsai, C.-C. 188 Tye, B.-K. 154 Udenfriend, S. 360 Ukena, T. E. 258 Van Holde, K. E. 79 Van Wart, H. E. 13 Vaughan, M. 74 Wachter, E. 84 Wahren, J. 348 Waks, M. 64 Waters, R. 238 Weiss, B. 154 Wiktor, T. J. 334 Willingham, M. 243 Wimmer, E. 59 Wittenberg, J. B. 203 Wong, M. 34 Wood, T. G. 178 Wright, T. C. 258 Yamamoto, H. 144 Yamamoto, S. 144 Yamane, T. 87 Yang, N. S. 310 Yanofsky, C. 286 Yip, Y. K. 64 Yoshinaga, K. 379 Zipp, A. 1 zur Hausen, H. 363



Contents (Continued from page viii)

Assignment of the integration site for simian virus 40 to chromosome 17 in GM54VA, a human cell line transformed by simian virus 40 (rodent-human hybrids/tumor antigen/viral transformation) ..............

............................................................................. Carl o M . Croce 315-318 Microcell-mediated transfer of murine chromosomes into mouse, Chinese hamster, and human somatic cells

(somatic cell genetics/gene mapping) ........................... R. E. K. Fournier and F. H. Ruddle 319-323 Mechanism of a case of genetic coadaptation in populations of Drosophila melanogaster (segregation distor-

tion/polymorphism/natural selection/linkage disequilibrium) ...................... Daniel L. Hartl 324-328

IMMUNOLOGY Development of tumor cell resistance to syngeneic cell-mediated cytotoxicity during growth of ascitic masto- cytoma P815Y (tumor-associated antigens/tumor escape) ..... William E. Biddison and Jon C. Palmer 329-333

In vitro evidence of cell-mediated immunity after exposure of mice to both live and inactivated rabies virus (rabies vaccine/thymus-derived cells/immunosuppression/H-2 genes/f3-propiolactone) ..............

. ................................................ T. J. Wiktor, P. C. Doherty, and H. Koprowski 334-338 Immunological defect and its correction in the osteopetrotic mutant rat (thymus/bone/thymus-derived cell/

bone-marrow-derived cell/mitogens) .......................................................... .......... Gerard Milhaud, Marie-Louise Labat, Monique Parant, Chantal Damais, and Louis Chedid 339-342

MEDICAL The humoral immune response of NIH Swiss and SWR/J mice to vaccination with formalinized AKR or Gross SCI ENCES murine leukemia virus (C-type virus vaccinelantibody)............... ...............

. . .John C. Lee, James N. Ihle, and Robert Huebner 343-347 Glucose homeostasis during prolonged suppression of glucagon and insulin secretion by somatostatin (glucose

turnover/diabetes mellitus) .................................................................. .................. Robert S. Sherwin, Rosa Hendler, Ralph DeFronzo, John Wahren, and Philip Felig 348-352

Rauscher-leukemia-virus-related sequences in human DNA: Presence in some tissues of some patients with hematopoietic neoplasias and absence in DNA from other tissues (human leukemia/multiple myeloma/ Hodgkin's disease/nucleic acid hybridization/type-C RNA tumor virus) ...........................

........................................................ Gurmit S. Aulakh and Robert C. Gallo 353-357 B3-Endorphin: Stimulation of growth hormone release in vivo (endogenous opiate/pituitary-brain/rat/me-

thionine-enkephalin/somatotropin) .......................... . . . . ................ .Andre Dupont, Lionel Cusan, Marie Garon, Fernand Labrie, and Choh Hao Li 358-359

Reduction of blood pressure and vascular collagen in hypertensive rats by (3-aminopropionitrile (hyperten- sion/blood vessels) . . Kazuhiko Iwatsuki, George J. Cardinale, Sydney Spector, and Sidney Udenfriend 360-362

Transient induction of a nuclear antigen unrelated to Epstein-Barr nuclear antigen in cells of two human B-lymphoma lines converted by Epstein-Barr virus (iododeoxyuridine induction/immunofluorescence/ transiently induced nuclear antigen) ..................... Karl-Otto Fresen and Harald zur Hausen 363-366

Inhibition of erythrocyte sickling in vitro by I)L1-glyceraldehyde (antisickling agent /gelation/oxygen affinity/hemoglobin S) .......................... Alan M. Nigen and James M. Manning 367-371

MI[CROBIC)LOGY Identification of virion polypeptides in hamster cells transformed by herpes simplex virus type I (surface labeling/immunoprecipitation/polyacrylamide gel elect rophoresis) . ..Phalguni Gupta and Fred Rapp 372-374

PHYSIOLOGICAL Development of the nervous system of Aplysia californica (neurobiology/neuronal development/mor- SCIENCES phology) .......... Arnold R. Kriegstein 375-378

Carcass components at first estrus of rats on high-fat and low-fat diets: Body water, protein, axnd fat (pu- berty/calorie intake/fatness/lean body mass/body composition) .................................. .................................................. R . E. Frisch, D. M. Hegsted, and K. Yoshinaga 379-383

POPULATl,,'ION Measures of fitness and demographic stability (Malthusian parameter/entropy/natural selection). BIOLOGY .............................. ... .Lloyd Demetrius 384-386

Extension of longevity in Drosophila mojavensis by environmental ethanol: Differences between subraces (alcohol dehydrogenase/isozyme thermostability/environmental heterogeneity) ....................

. ................................ William T. Starmer, William B. Heed, and E. S. Rockwood-Sluss 387-391 Corrections

BIOC,HEMISTRY Calcium control of actin-activated myosin adenosine triphosphatase from Dictyostelium discoideum (cell

movement/cell shape/nonmuscle contraction/affinity chromatography) ...................... ..... ................ ...... Stephen C. Mockrin and James A. S;pudich 392

Stereochemistry of polymerization by DNA-dependent RNA-polymerase from Escherichia coli: An investi- gation with a diastereomeric ATP-analogue ladenosine 5'-O-(I-thiotripho.sphate)luridine 2',3'-cyclic phosphorothioate/ 3IP-nuclear magnetic resonance I . . F. Eckstein, V. W. Armstrong, and H. Sternbach 392

CERLL B1I,OLOY A potassium iono)phore (valinomycin) inhibits lymphocyte proliferation by its effects on the cell memb)rane (inhibition lymphocyte mito)genesi.s/cation.s) ................ Ronald P. I)aniele and Sandra K. Hoslian . ............. 392

vii



Contents ((tottiti,iued from irnsidet back (over)

BIOPHYSICS Ligand kinetics of hemoglobin S containing erythrocytes (sickling/rate of oxygenation/polymerization) ... ........................................................................ PJhn P. H arrington, . ................ Danek Elbaum, Robert M. Bookchin, Jonathan B. Wittenberg, and Ronald L. Nagel 203--206

Rhodopsin in model membranes: Charge displacements in interfacial layers (visual excitation/early receptor potential/protein conformation/surface potential/photoelectric signals)u...

... ................................................... H.- W. 7'rissl, A. Darszon, and M. Montal 207-21() Density of sodium channels in mammalian myelinated nerve fibers and nature of the axonal membrane under

the myelin sheath (saxitoxin/saltatory conduction/demyelinating disease) ......................... . ............................................................... J. M . Ritchie and R. B. Rogart 21 1 _-215

Nuclear coupling of *3S and the nature of free radicals in irradiated crystals of N-acetyl-L,-cysteine (electron spin resonance/:3'S hyperfine structure) ............... Joseph H. Hadley, Jr. and Walter (;ordy 216.. 220

Bacterial flagella rotating in bundles: A study in helical geometry (motility/chemotaxis/peritrichous/hy- drodynamics/intertwisting) ................................................ Robert N. Macnab 221-225

Electronic properties of the casein-methylglyoxal complex (semiconductivity/electron spin resonance/mi- crowvave dielectric measurements/electronic transference number) ................................

. .................................................. Ronald Pethig and Albert Szent-(Gye3rgyi 226-228 Experimental test of the vibronically coupled tunneling description of biological electron transfer (electron

tunneling/cytochrome c/electron transfer) ........................ M. J. Potasek and J. J. Hopfield 229-233 CELL, BIOLOGY 3':5'-Cyclic AMP": Independent induction of amino acid transport by epinephrine in primary cultures of

adult rat liver cells ((a-adrenergic/l-adrenergic/catecholamine/a-aminoisobutyric acid/refractoriness) ........................... .Michael W. Pariza, Fred R. Butcher, Joyce E. Becker, and Van R. Potter 234_237

Partial inhibition of postreplication repair and enhanced frequency of chemical transformation in rat cells infected with leukemia virus (Rauscher leukemia virus/4-nitroquinoline- i-oxide) .....................

.......... Raymond Waters, Nirmal Mishra, Noel Bouck, Giampiero DiMayorca, and James I). Regan 2:38-242 Itole of cell surface carbohydrates and proteins in cell behavior: Studies on the biochemical reversion of an

N-acetylglucosamine-deficient fibroblast mutant (cell surface glycoproteins/membrane mutant/growth control/phenotypic transformation/3T3 Balb cells) .............................................

. ........................................ Jacques Pouyss4gur, Mark Willingham, and Ira Pastan 243-247 Transient inhibition of initiation of S-phase associated with dimethy sulfoxide induction of murine erythro-

leukemia cells to erythroid differentiation (Friend cell/cell cycle/cell differentiation) ................ .................. .Masaaki Terada, Jerrold Fried, Uri Nudel, Richard A. Rifkind, and Paul A. Marks 248--252

Chromosome mapping of the genes that control differentiation and malignancy in myeloid leukemic cells (macrophage and granulocyte inducer/Fc and C3 receptors/differentiation mutants/mouse chromosomes 2 and 12) .............. Jun-lchi Azumi and Leo Sachs 25.3--257

Rates of aggregation, loss of anchorage dependence, and tumorigenicity of cultured cells (concanavalin A/ methyl cellulose) ... 7homas C. Wright, 7homas E. Ukena, Russell Campbell, and Morris J. Karnov.sky 258--262

Ilhosphorylation of membrane proteins at a cholinergic synapse (cholinergic ligands/protein kinase/acetyl- choline receptor/postsynaptic membrane/nicotinic cholinergic synapses)t......

. ...................................... Adrienne S. Gordon, C. Geoffrey l)avis, and Ivan Diamond 263-267 A potassium ionophore (valinomycin) inhibits lymphocyte proliferation by its effects on the cell membrane

(Correction) (inhibition lymphocyte mitogenesis/cations) .... Ronald P. Ianiele and Sandra K. Holian . 392 (Cell differentiation in Dictyostelium under submerged conditions (oxygen/polarity/pattern formation) ..

.. .............................................................. J. Sternfeld and J. 7'. Bonner 268-271 Rejection by syngeneic mice of cell variants obtained by mutagenesis of a malignant teratocarcinoma cell

line (tumor immunology) ........................... 7hierry Boon and Odile Kellermann 272-275 Antigen-specific nonimmunoglobulin factor that neutralizes xenotropic virus is associated with mouse serum

lipoproteins (murine C-type virus/ultracentrifugal separation) ................................... ................................. .JoAnn C. Leong, John P. Kane, Oksana Oleszko, and Jay A. Levy 276-280

GENETICS Infectious DNA of spleen necrosis virus is integrated at a single site in the 1)NA of chronically infected chicken fibroblasts (RNA tumor virus/provirus/restriction enzymes/agarose gel electrophoresis) ....

..................................................... .Narayana Battula and Howard M. 7'emin 281285 Structure and properties of a hybrid tryptophan synthetase (a chain produced by genetic exchange between

Escherichia coli and Salmonella typhimurium (hybrid polypeptide/intragenic recombination/molecular evolution) ........ Charles Yanofsky, Steven S.-L. Li, Virginia Horn, and Joan RIowe 286 -290

Initiation of genetic exchanges in X phage-prophage crosses (recombination/crosslinks/excision/recA gene/ recH gene) ........ Pin-Fang Lin, Eva Bardwell, and Paul Howard-Flanders 291-295

Inhibitors of genetic recombination in pneumococci (genetic transformation/DNA intercalation/ethidium bromide) ........ Hiroyuki Seto and Alexander T'omasz 296-299

A mutant of Escherichia coli showing constitutive expression of the lysogenic induction and error-prone DNA repair pathways (phage X repressor/mutator/lexA/lUV repair) ................ )avid W. Mount 300' :304

Nonsense suppressors of yeast cause osmotic-sensitive growth (tRNA mutants/mappings,/Saccharomyces cerevisiae/efficien y of sup pression/anti.su ppre.ssor.s) ..........................Arjun S ingh 30..... s)5-30(9

GXenetic control of mitochondrial malate dehydrogenases: Evidence for duplicated chromosome segments (gJene duplication/gene evolution/mitochondrial gyenetic.s/gene-enzyme syKstems )...........

(Conftinued on page lii)

viii



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