Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 75, No. 8 (Aug., 1978), pp. v-xiiPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/68713 .

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AUGUST 1978

VOLUME 75

NUMBER 8

csOF

Proceedings OF THE

National Academy of Sciences O)F THE UNITED STATES OF AMERICA

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THE PROCEEDINGS OF THE

National Academy of Sciences OF THE UNITED STATES OF AMERICA

Officers of the Academy

PHILIP HANDLER President SAUNDERS MAC LANE Vice President DAVID R. GODDARD Home Secretary THOMAS F. MALONE Foreign Secretary E. R. PIORE Treasurer

Editorial Board of the Proceedings

ROBERT L. SINSHEIMER Chairman ROBERT M. SOLOW Vice Chairman HARRISON SHULL Vice Chairman DAVID R. GODDARD Home Secretary THOMAs F. MALONE Foreign Secretary E. R. PIORE Treasurer

K. FRANK AUSTEN S. M. LIPSET ALEXANDER G. BEARN EUGENE P. ODUM P. D. BOYER ALEXANDER RICH JULIUS H. COMROE, JR. E. R. STADTMAN JOHN E. DOWLING ELIAS M. STEIN HARRY EAGLE HOWARD M. TEMIN RICHARD M. HELD JAMES TOBIN HENRY S. KAPLAN CHARLES H. TOwNES

Managing Editor: BERNARD K. FORSCHER Associate Editor: GARY T. COCKS Associate Editor: MURRIE W. BURGAN Associate Editor: SHEILA L. ROSENTHAL -Assistant Managing Editor: STEPHANIE G. PASSMAN

Editorial correspondence: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, Washington, DC 20418.

Business correspondence: Circulation Office of the PROCEEDINGS, National Academy of Sciences, 2101 Constitution Avenue, Washington, DC 20418.

Copyright: The National Academy of Sciences has copyrighted this journal as a collective work and does not own copyrights for individual articles. For reprints of individual articles, requests should be addressed to the authors. Microforms of complete volumes are available to regular subscribers only and may be obtained from University Microfilms, Xerox Corporation, Ann Arbor, MI 48103.

Subscriptions: All correspondence concerning subscriptions should be addressed to the Circulation Office of the Proceedings. Subscriptions are entered on a calendar year basis only. The 1978 subscription rate is $60. Subscribers are requested to notify the Circulation Office of the Proceedings 6 weeks in advance of any change of address; also the local postmaster. The Academy is not responsible for nonreceipt of issues because of improper address unless a change of address is on file. The notice of address change should list both the old and new addresses. Claims for replacement copies will not be honored more than 60 days after the issue date for domestic subscribers and not more than 90 days after the issue date for foreign sub- scribers.

Back Issues (Volumes 1-69, through December 1972) are available from Walter J. Johnson, Inc., 355 Chestnut Street, Norwood, NJ 07648. Prices are available from that organization upon request. Back Issues (Volumes 70-75, January 1973 and thereafter) are available from the Circulation Office of the Proceedings. The price of a single issue is $7.50.

Second cklss postage paid at Washington, DC, and at additional mailing offices. PRINTED IN THE USA

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA is published monthly by THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, Washington, DC 20418

?3 1978 by THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.

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AUTHOR INDEX, AUGUST 1978

Abel, D. 3871 Aguilera, G. 4057 Albright, J. F. 3923 Albright, J. W. 3923 Allison, J. P. 3953 Altman, S. 3717 Ambler, R. P. 3732 Anderson, H. C. 3805 Austen, K. F. 3831 Bank, A. 3801 Barany, M. 3588 Barde, Y. A. 4042 Barrett, J. C. 3761 Bartfeld, D. 4006 Beadling, L. 3669 Beg, Z. H. 3678 Beglau, J. M. 4067 Bell, M. 3913 Benzer, S. 4047 Bernhard, S. 3613 Bernhardt, J. 3756 Beutler, E. 3823 Blair, H. E. 3970 Bleich, H. E. 3630 Bluestein, H. G. 3965 Bowman, E. J. 3717 Brady, R. 0. 3970 Brewer, H. B., Jr. 3678 Brinkley, B. R. 3771 Britton, D. E. 3970 Brockbank, K. 3826 Broome, S. 3727 Brown, T. R. 3742 Calvert, P. C. 3598 Candido, E. P. M. 3574 Cantor, C. R. 3564 Caplan, A. I. 3871 Carter, C. W., Jr. 3649 Caruthers, M. H. 3578 Case, K. M. 3562 Catt, K. J. 4057 Catterall, J. F. 3688 Chenoweth, D. E. 3943 Chick, W. L. 3727 Christian, C. N. 4011 Cohen, R. S. 4016 Coleman, P. S. 3766 Conzelmann, E. 3979 Cooper, S. R. 3551 Costa, E. 4024 Cuatrecasas, P. 3693 Czop, J. K. 3831 Dahlberg, A. E. 3598 Dahlberg, J. E. 3598 D'Andrea, A. D. 3608 Daniels, M. P. 4011 Datta, P. 3859 Davie, J. R. 3574 Davies, J. E. 3673 Dedman, J. R. 3771 De Larco, J. E. 4001 den Hollander, J. A.

3742 Deobagkar, D. N. 3974 De Wilde, M. 3673 Diedrich, D. L. 3708 Dressler, D. 3698 Dreyfuss, Y. 3989 Dugaiczyk, A. 3688 Dun, N. J. 4029 Duncan, C. H. 3664 Dusanic, D. G. 3923 Edgell, M. H. 3881 Efstratiadis, A. 3727 Elder, J. H. 3644 Ewell, A. J. 3766

Ewig, R. A. G. 3809 Fearon, D. T. 3831 Ferrone, S. 3953 Fischer, J. A. 3984 Fishkes, H. 3713 Forde, B. G. 3841 Fox, C. F. 3644 Franke, W. W. 3791 Freer, R. J. 3630 Frelinger, J. A. 3953 Friedman, E. A. 3813 Friend, C. 3851 Fries, E. 3846 Fuchs, S. 4006 Fuller, F. B. 3557 Gabelman, N. 3851 Galardy, R. E. 3630 Gambari, R. 3801 Ganetzky, B. 4047 Gantt, R. 3809 Garner, W. H. 3618 Geibel, J. F. 3747 Gerber, L. D. 4021 Gilbert, W. 3727 Glynn, P. 3742 Goddard, J. M. 3886 Goeddel, D. V. 3578 Goldberg, I. H. 3603 Good, R. A. 3766 Granger, B. L. 3683 Greengard, P. 4037 Grollman, A. P. 3603 Gross, L. 3989 Guidotti, A. 4024 Gurdon, J. B. 3791 Guze, L. B. 3993 Halliburton, I. W. 3896 Hannig, V. L. 3909 Harris, H. 3909 Haseltine, W. A. 3608 Haspel, M. V. 4033 Hatayama, T. 3603 Hawkes, S. P. 3703 Hayaishi, 0. 3998 Hebdon, M. 3693 Heggeness, M. H. 3863 Helenius, A. 3846 Henry, N. 3933 Hoy, R. R. 4052 Hsu, H. H. T. 3805 Hugli, T. E. 3943 Hunziker, W. 3984 Inui, K.-I. 3856 Isselbacher, K. J. 3856 Jacques, L. 4011 Jan, L. Y. 4047 Jan, Y.-N. 4047 Jelenc, P. C. 3564 Jensen, F. C. 3644 Jones, G. M. 3809 Kado, C. I. 3796 Kamen, M. D. 3640 Kanner, B. I. 3713 Kaplan, N. 0. 3640 Kaplan, N. 0. 4067 Kapmeyer, W. 4067 Karczmar, A. G. 4029 Karle, J. 3540 Khan, S. 3826 Klibanov, A, M. 3640 Knipe, D. M. 3896 Koch, G. 3876 Kohn, K. W. 3809 Kole, R. 3717 Koprowski, H. 3938 Korchak, H. M. 3818

Koshland, D. E., Jr. 3659

Kredich, N. M. 3928 Krug, S. 3871 Ladik, J. 3548 Lai, E. C. 3688 Laki, K. 3548 Lampert, P. W. 4033 Lappi, D. A. 4067 Lazarides, E. 3683 Leaver, C. J. 3841 Leder, A. 3881 Leder, P. 3881 Lerch, K. 3635 Lerner, R. A. 3644 Lesavre, P. H. 3948 Le Vine, H., III 3693 Lewis, R. V. 4021 Liesegang, B. 3901 Little, J. B. 3962 Lohmann, S. M. 4037 Lomedico, P. 3727 London, I. M. 3654 Lotem, J. 3781 Lund, E. 3598 McArdle, J. V. 3551 McConnell, H. M. 3933 McKean, D. J. 3913 Maitra, S. K. 3993 Mak, A. 3588 Marcum, J. M. 3771 Marks, P. A. 3801 Mayberry, J. P. 3537 Means, A. R. 3771 Merigan, T. C. 3957 Miranda, A. F. 3826 Moiseff, A. 4052 Moran, J. 3984 Morein, B. 3846 Morton, N. E. 3906 Moss, J. 3621 Mulivor, R. A. 3909 Muller-Eberhard, H. J.

3948 Naber, S. P. 3727 Nakashima, K. 3823 Nandi, S. 3836 Natraj, C. V. 3859 Nelson, P. G. 4011 Nette, E. G. 3826 Neumann, E. 3756 Nishino, H. 3856 Nomura, M. 3891 Nove, J. 3962 Oishi, M. 3569 Old, L. J. 3918 Oldstone, M. B. A. 4033 Oliver, R. J. C. 3841 O'Malley, B. W. 3688 Otto, P. 3548 Pallmann, B. 4067 Pangburn, M. K. 3948 Parce, J. W. 3933 Parry, G. 3703 Parshad, R. 3809 Pattison, S. 3613 Pellegrino, M. A. 3953 Penhoet, E. E. 3625 Pentchev, P. G. 3970 Pike, M. C. 3928 Pollack, G. S. 4052 Polsky, F. 3881 Potter, H. 3698 Potter, M. 3913 Price, P. 3851 Privalsky, M. L. 3625

v

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AUTHOR INDEX, AUGUST 1978

Rabson, A. B. 3598 Radbruch, A. 3901 Rajewsky, K. 3901 Ranney, H. M. 3747 Ranu, R. S. 3654 Rasmussen, L. 3957 Raymond, K. N. 3551 Reisfeld, R. A. 3953 Reynolds, F. 3598 Reynolds, F. H., Jr. 3974 Richards, J. 3836 Rifkind, R. A. 3801 Risser, R. 3918 Robinson, P. 3846 Roizman, B. 3896 Rosenbusch, J. P. 3751 Rothfield, L. I. 3669 Rubinstein, M. 4021 Russell, W. A. 3953 Ruyechan, W. T. 3896 Ryser, H. J.-P. 3867 Sachs, L. 3781 Sacks, T. L. 3974 Sahyoun, N. 3693 Samuelson, P. A. 4062 Sandhoff, K. 3979 Sandhoff, K. 4067 Sanford, K. K. 3809 Sassa, S. 3851 Scher, W. 3851 Scherrer, K. 3776 Schildkraut, C. L. 3813 Schiller, R. M. 3856 Schindler, H. 3751 Schirrmacher, V. 3846 Schmidt, F. J. 3673 Schmitges, C. J. 3693 Schnaitman, C. A. 3708 Schonberg, M. 3826 Schotz, M. C. 3993 Schreiber, R. D. 3948 Schuldiner, S. 3713 Scott, G. K. 3732

Seegmiller, J. E. 3722 Seidman, J. G. 3881 Sharma, V. S. 3747 Shen, W.-C. 3867 Shows, T. B. 3876 Shulman, R. G. 3742 Siekevitz, P. 4016 Silver, J. 3953 Simon, M. 3863 Simon, S. R. 3564 Simons, K. 3846 Singer, S. J. 3863 Sirbasku, D. A. 3786 Smillie, L. B. 3588 Smith, C. L. 3569 Snyderman, R. 3928 Sonoki, S. 3796 Sorrell, S. H. 3970 Spector, A. 3618 Stafford, S. S. 3630 Stark, B. C. 3717 Stein, S. 4021 Steitz, J. A. 3593 Stephenson, J. R. 3974 Stock, J. B. 3659 Stockert, E. 3918 Stonik, J. A. 3678 Stoop, J. W. 3722 Strominger, J. L. 3846 Suda, K. 4042 Sugiyama, H. 4011 Sutcliffe, J. G. 3737 Szent-Gyorgyi, A. 3548 Takemoto, L. J. 3644 Takeshita, M. 3603 Tarone, R. E. 3809 Tatchell, K. 3583 Terada, M. 3801 Terhorst, C. 3846 Therwath, A. 3776 Thoenen, H. 4042 Thompson, L. F. 3722 Tiemeier, D. C. 3881

Tilghman, S. M. 3881 Tillotson, L. G. 3856 Tizard, R. 3727 Todaro, G. J. 4001 Toffano, G. 4024 Tokimatsu, H. 3598 Trachsel, H. 3654 Trendelenburg, M. F.

3791 Tsai, M.-J. 3688 Ts'o, P. 0. P. 3761 Tsuei, D. 3851 Tzeng, M.-C. 4016 Udenfriend, S. 4021 Ueda, T. 4037 Ugurbil, K. 3742 Van Holde, K. E. 3583 Vaughan, M. 3621 Villa-Komaroff, L. 3727 Vogel, Z. 4011 Walker, L. E. 3953 Weichselbaum, R. R.

3962 Weissmann, G. 3818 Wiktor, T. J. 3938 Willis, R. C. 3722 Wilson, G. A. 3664 Wolstenholme, D. R.

3886 Woo, S. L. C. 3688 Wu, C.-F. 4047 Yamamoto, M. 3891 Yansura, D. G. 3578 Yoshida, R. 3998 Yoshikawa, T. T. 3993 Young, F. E. 3664 Young, R. A. 3593 Zahalak, M. 3598 Zeilberger, D. 3555 Zentgraf, H. 3791 Zull, J. E. 3871

vi

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Contents (Continued from page ix)

POPULATION BIOLOGY

4062-4066 Paul A. Samuelson Generalizing Fisher's "reproductive value": Overlapping and nonoverlapping generations with competing genotypes (dilute

systems/homogeneous functions/Hardy-Weinberg model/biparental genetics)

Corrections

BIOCHEMISTRY

4067 Konrad Sandhoff and Bernhard Pallmann Membrane-bound neuraminidase from calf brain: Regulation of oligosialoganglioside degradation by membrane fluidity and

membrane components (lipophilic and hydrophilic substrates/inhibitors/general anesthetics/fluorescence depolarization)

4067 Douglas A. Lappi, Wolfgang Kapmeyer, Janice M. Beglctu, and Nathan 0. Kaplan The disulfide bond connecting the chains of ricin (A-B chain cormplex/reduction of ricin/protein synthesis inhibition/

ultracentrifugation/ricin purification)

Vlll

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Contents (Continued from page x)

3970-3973 Peter G. Pentchev, Roscoe 0. Brady, Henry E. Blair, Daniel E. Britton, and Susan H. Sorrell Gaucher disease: Isolation and comparison of normal and mutant glucocerebrosidase from human spleen tissue (copurificationl

immunotitration/heat-stable factor/structural mutation)

3974-3978 Fred H. Reynolds; Jr., Thomas L. Sacks, Dileep N. Deobagkar, and John R. Stephenson Cells nonproductively transformed by Abelson murine leukemia virus express a high molecular weight polyprotein containing

structural and nonstructural components (RNA tumor viruses/transforming proteins/gag gene-coded translational products/pseudotype virions/virus-coded phosphoproteins)

3979-3983 E. Conzelmann and K. Sandhoff AB variant of infantile GM2 gangliosidosis: Deficiency of a factor necessary for stimulation of hexosaminidase A-catalyzed

degradation of ganglioside GM2 and glycolipid GA2 (lipid storage disease/activator deficiency)

3984-3988 Julio Moran, Willi Hunziker, and Jan A. Fischer Calcitonin and calcium ionophores: Cyclic AMP responses in cells of a human lymphoid line (calcitonin analogues/lymphocytes/

receptors)

3989-3992 Ludwik Gross and Yolande Dreyfuss Relative loss of oncogenic potency of mouse leukemia virus (Gross) after prolonged propagation in tissue culture ("passage A"

virus/attempt at immunization/virus passage in mice)

3993-3997 Shyamal K. Maitra, Michael C. Schotz, Thomas T. Yoshikawa, and Lucien B. Guze Determination of lipid A and endotoxin in serum by mass spectroscopy (/3-hydroxymyristic acid/gas chromatography-mass

spectrometry/Gram-negative sepsis)

3998-4000 Ryotaro Yoshida and Osamu Hayaishi Induction of pulmonary indoleamine 2,3-dioxygenase by intraperitoneal injection of bacterial lipopolysaccharide (lung/endotoxin)

MICROBIOLOGY

4001-4005 Joseph E. De Larco and George J. Todaro Growth factors from murine sarcoma virus-transformed cells (epidermal growth factor/polypeptide hormones/cell

transformation/radioreceptor assays)

NEUROBIOLOGY

4006-4010 Daniel Bart/eld and Sara Fuchs Specific immunosuppression of experimental autoimmune myasthenia gravis by denatured acetylcholine receptor (Torpedo

acetylcholine receptor/reduced carboxymethylated acetylcholine receptor/specific therapy/antibody specificity)

4011-4015 C. N. Christian, M. P. Daniels, H. Sugiyama, Z. Vogel, L. Jacques, and P. G. Nelson A factor from neurons increases the number of acetylcholine receptor aggregates on cultured muscle cells (synaptogenesis/

neurotrophic factor/membrane receptor mobility)

4016-4020 Mu-Chin Tzeng, Rochelle S. Cohen, and Philip Siekevitz Release of neurotransmitters and depletion of synaptic vesicles in cerebral cortex slices by ae-latrotoxin from black widow spider

venom (y-aminobutyric acid/brain cortex/neurotoxin)

4021-4023 Randolph V. Lewis, Stanley Stein, Louise D. Gerber, Menachem Rubinstein, and Sidney Udenfriend High molecular weight opioid-containing proteins in striatum (enkephalin/opioid peptide/biosynthetic pathway)

4024-4028 G. Toffano, A. Guidotti, and E. Costa Purification of an endogenous protein inhibitor of the high affinity binding of y-aminobutyric acid to synaptic membranes of rat

brain (endogenous inhibitor/y-aminobutyric acid synapses/y-aminobutyric acid receptors)

4029-4032 N. J. Dun and A. G. Karczmar Involvement of an interneuron in the generation of the slow inhibitory postsynaptic potential in mammalian sympathetic ganglia

(disynaptic event/catecholamine hyperpolarization/small intensely fluorescent cells)

4033-4036 Martin V. Haspel, Peter W. Lampert, and Michael B. A. Oldstone Temperature-sensitive mutants of mouse hepatitis virus produce a high incidence of demyelination (coronavirus/model system/

electron microscopy/virus virulence)

4037-4041 Suzanne M. Lohmann, Tetsufumi Ueda, and Paul Greengard Ontogeny of synaptic phosphoproteins in brain (protein I/protein kinase/cyclic AMP/protein phosphorylation)

4042-4046 K. Suda, Y. A. Barde, and H. Thoenen Nerve growth factor in mouse and rat serum: Correlation between bioassay and radioimmunoassay determinations

(immunoglobulins/affinity chromatography/serum proteins)

4047-4051 Chun-Fang Wu, Barry Ganetzky, Lily Yeh Jan, Yuh-Nung Jan, and Seymour Benzer A Drosophila mutant with a temperature-sensitive block in nerve conduction (neurogenetics/paralysis/action potential)

4052-4056 Andrew Moiseff, Gerald S. Pollack, and Ronald R. Hoy Steering responses of flying crickets to sound and ultrasound: Mate attraction and predator avoidance (phonotaxis/acoustic

communication/neuroethology/frequency discrimination/insect hearing)

PHYSIOLOGICAL SCIENCES

4057-4061 G. Aguilera and K. J. Catt Regulation of aldosterone secretion by the renin-angiotensin system during sodium restriction in rats (angiotensin If/adrenal

receptors/sodium deficiency/steroidogenesis/converting enzyme inhibitor)

(Continued ofl page viii) ix

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Contents (Continued from page xi)

GENETICS

3876-3880 George Koch and Thomas B. Shows A gene on human chromosome 6 functions in assembly of tissue-specific adenosine deaminase isozymes (somatic cell hybrids/gene

mapping/immune deficiency disease)

3881-3885 J. G. Seidman, Aya Leder, Marshall H. Edgell, Fred Polsky, Shirley M. Tilghman, David C. Tiemeier, and Philip Leder Multiple related immunoglobulin variable-region genes identified by cloning and sequence analysis (K light chain/subgroups/

DNA sequencing)

3886-3890 Judy M. Goddard and David R. Wolstenholme Origin and direction of replication in mitochondrial DNA molecu:les from Drosophila melanogaster (electron microscopy/

restriction enzymes/denaturation mapping/adenine + thymine-rich DNA)

3891-3895 Masayuki Yamamoto and Masayasu Nomura Cotranscription of genes for RNA polymerase subunits :3 and d3' with genes for ribosomal proteins in Escherichia coli (transducing

phages/gene cloning/rifampicin/RNA nucleotidyltransferase)

3896-3900 David M. Knipe, William T. Ruyechan, Bernard Roizman, and Ian W. Halliburton Molecular genetics of herpes simplex virus: Demonstration of regions of obligatory and nonobligatory identity within diploid

regions of the genome by sequence replacement and insertion (reiterated sequences/marker rescue/recombination)

3901-3905 Bernhard Liesegang, Andreas Radbruch, and Klaus Rajewsky Isolation of myeloma variants with predefined variant surface im:munoglobulin by cell sorting (somatic cell variants/

immunoglobulin genes/cell surface antigens/fluorescence-activated cell sorter)

3906-3908 N. E. Morton Effect of inbreeding on IQ and mental retardation (consanguinity/dominance/segregation analysis)

3909-3912 Richard A. Mulivor, Vickie L. Hannig, and Harry Harris Developmental change in human intestinal alkaline phosphatase (fetal/adult/electrophoresis/inhibition)

IMMUNOLOGY

3913-3917 David J. McKean, Michael Bell, and Michael Potter Mechanisms of antibody diversity: Multiple genes encode structurally related mouse K variable regions (amino acid sequence/

genetics of antibody diversity/VK-21 isotype)

3918-3922 Rex Risser, Elisabeth Stockert, and Lloyd J. Old Abelson antigen: A viral tumor antigen that is also a differentiation antigen of BALB/c mice (murine leukemia viruses/cell surface

antigens/leukemia)

3923-3927 Julia W. Albright, Joseph F. Albright, and Donald G. Dusanic Mechanisms of trypanosome-mediated suppression of humoral imnmunity in mice (suppressor T cells/macrophages/in vitro

culture)

3928-3932 Marilyn C. Pike, Nicholas M. Kredich, and Ralph Snyderman Requirement of S-adenosyl-L-methionine-mediated methylation for human monocyte chemotaxis [adenosine/adenosine

deaminase/erythro-9- (2-hydroxy-3-nonyl)adenine/phagocytosis/S-adenosyl-L-homocysteine]

3933-3937 Nicole Henry, J. Wallace Parce, and Harden M. McConnell Visualization of specific antibody and Clq binding to hapten-sensitized lipid vesicles (freeze-etch electron microscopy/spin labels/

complement/phospholipid vesicles)

3938-3942 T. J. Wiktor and H. Koprowski Monoclonal antibodies against rabies virus produced by somatic cell hybridization: Detection of antigenic variants (mouse

hybridomas)

3943-3947 Dennis E. Chenoweth and Tony E. Hugli Demonstration of specific C5a receptor on intact human polymo:rphonuclear leukocytes (leukocyte chemotaxis/anaphylatoxin/

complement/C5a derivatives)

3948-3952 Robert D. Schreiber, Michael K. Pangburn, Philippe H. Lesavre, and Hans J. Maller-Eberhard Initiation of the alternative pathway of complement: Recognition- of activators by bound C3b and assembly of the entire pathway

from six isolated proteins (properdin system/nonspecific complement activation/C3b binding sites/regulation/ multimolecular interactions)

3953-3956 J. P. Allison, L. E. Walker, W. A. Russell, M. A. Pellegrino, S. Ferrone, R. A. Reisfeld, J. A. Frelinger, and J. Silver Murine Ia and human DR antigens: Homology of amino-terminal sequences (DR xenoantiserum/immunoprecipitation/two-chain

structure/allotype differences)

MEDICAL SCIENCES

3957-3961 Lucy Rasmussen and Thomas C. Merigan Role of T lymphocytes in cellular immune responses during herpes simplex virus infection in humans (lymphocyte transformation!

interferon)

3962-3964 Ralph R. Weichselbaum, John Nove, and John B. Little X-ray sensitivity of diploid fibroblasts from patients with herediitary or sporadic retinoblastoma (DNA repair/carcinogenesis!

genetic susceptibility)

3965-3969 Harry G. Bluestein Neurocytotoxic antibodies in serum of patients with systemic lupus erythematosus (human cells/neuroblastoma/glioblastoma/

lymphocytotoxic antibodies)

(Continued on page ix)

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Contents (Continued from page xii)

3786-3790 David A. Sirbasku Estrogen induction of growth factors specific for hormone-responsive mammary, pituitary, and kidney tumor cells (rat uterine and

kidney activity/hamster liver and kidney activity/target cell specificity/heat stability)

3791-3795 M. F. Trendelenburg, H. Zentgraf, W. W. Franke, and J. B. Gurdon Transcription patterns of amplified Dytiscus genes coding for ribosomal RNA after injection into Xenopus oocyte nuclei (electron

microscopy/chromatin morphology/nucleoli/RNA synthesis/living oocytes)

3796-3800 S. Sonoki and C. I. Kado Proteins conferred by the virulence-specifying plasmid of Agrobacterium tumefaciens C-58 (periplasmic proteinsltwo-

dimensional gel electrophoresis/transconjugant/deletion plasmid)

3801-3804 Roberto Gambari, Masaaki Terada, Arthur Bank, Richard A. Rifkind, and Paul A. Marks Synthesis of globin mRNA in relation to the cell cycle during induced murine erythroleukemia differentiation (Friend virus/

dimethyl sulfoxide/hexamethylene bisacetamide)

3805-3808 Howard H. T. Hsu and H. Clarke Anderson Calcification of isolated matrix vesicles and reconstituted vesicles from fetal bovine cartilage (mineralization/bone/epiphyseal

plate/phosphatase)

3809-3812 Raymond Gantt, Ram Parshad, Regina A. G. Ewig, Katherine K. Sanford, Gary M. Jones, Robert E. Tarone, and Kurt W. Kohn

Fluorescent light-induced DNA crosslinkage and chromatid breaks in mouse cells in culture (chromosomal aberrations in situ/ chromosomal analysis/radiation damage)

3813-3817 Eileen A. Friedman and Carl L. Schildkraut Lengthening of the GI phase is not strictly correlated with differentiation in Friend erythroleukemia cells (cell cycle/flow

microfluorometry/cell differentiation)

3818-3822 H. M. Korchak and Gerald Weissmann Changes in membrane potential of human granulocytes antecede the metabolic responses to surface stimulation (concanavalin A/

immune complexes/triphenylmethyl phosphon.ium ion/02-- generation)

3823-3825 Koji Nakashima and Ernest Beutler Effect of anti-spectrin antibody and ATP on deformability of resealed erythrocyte membranes (ektacytometer/phosphorylation/

dephosphorylation)

3826-3830 A. F. Miranda, E. G. Nette, S. Khan, K. Brockbank, and M. Schonberg Alteration of myoblast phenotype by dimethyl sulfoxide (differentiation/creatine phosphokinase/collagen)

3831-3835 Joyce K. Czop, Douglas T. Fearon, and K. Frank Austen Membrane sialic acid on target particles modulates their phagocytosis by a trypsin-sensitive mechanism on human monocytes

(alternative complement pathway/natural and modified activators/opsonin-independent ingestion)

3836-3840 James Richards and S. Nandi Neoplastic transformation of rat mammary cells exposed to 7,12-dimethylbenz[a]anthracene or N-nitrosomethylurea in cell culture

(epithelial cell chemical carcinogenesis in vitro/cell transplants)

3841-3845 Brian G. Forde, Robin J. C. Oliver, and Christopher J. Leaver Variation in mitochondrial translation products associated with male-sterile cytoplasms in maize (mitochondrial protein

synthesis/cytoplasmic inheritance/plant breeding)

20846-3850 Ari Helenius, Bror Morein, Erik Fries, Kai Simons, Peter Robinson, Volker Schirrmacher, Cox Terhorst, and Jack L. Strominger

Human (HLA-A and HLA-B) and murine (H-2K and H-2D) histocompatibility antigens are cell surface receptors for Semliki Forest virus (virus receptors/membrane proteins/nonionic detergent/HLA antigens/H-2 antigens)

3851-3855 W. Scher, D. Tsuei, S. Sassa, P. Price, N. Gabelman, and C. Friend Inhibition of dimethyl sulfoxide-stimulated Friend cell erythrodifferentiation by hydrocortisone and other steroids (Friend

leukemia virus/globin mRNA/glucocorticoids/pretranslational control)

3856-3858 Hoyoku Nishino, Loyal G. Tillotson, Robert M. Schiller, Ken-Ichi Inui, and Kurt J. Isselbacher Sodium-stimulated active transport of aminoisobutyric acid by reconstituted vesicles from partially purified plasma membranes of

mouse fibroblasts transformed by simian virus 40 (overshoot/electrochemical stimulation/dimethylmaleic anhydride treatment/liposomes)

3859-3862 C. V. Natraj and Prasanta Datta Uridine.diphosphate N-acetylglucosamine stimulates uptake of nutrients by quiescent BALB/C3T3 cells (2-deoxyglucose/

a-aminoisobutyric acid/serum stimulation/cell surface acceptors)

3863-3866 Michael H. Heggeness, Melvin Simon, and S. J. Singer Association of mitochondria with microtubules in cultured cells (intracellular transport)

3867-3870 Hugues J. -P. Ryser and Wei- Chiang Shen Conjugation of methotrexate to poly(L-lysine) increases drug transport and overcomes drug resistance in cultured cells (polymer-

bound drug/piggyback pinocytosis/membrane transport of mracromolecules/polycationic carrier)

DEVELOPMENTAL BIOLOGY

3871-3875 James E. Zull, Steven Krug, Diane Abel, and Arnold I. Caplan Development of parathyroid hormone- and calcitonin-activated adenylate cyclases in embryonic chicken limb and in cultured cells

from embryonic chicken limb (osteoblast/osteoclast/d evelo pm.ent/calcium metabolism )

(Conltinlued onl page x)

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Contents (Continued from inside back cover)

3698-3702 Huntington Potter and David Dressler In vitro system from Escherichia coli that catalyzes generalized genetic recombination (reciprocal recombination/plasmid DNAI

figure 8 structures/chi forms/initiation of recombination)

3703-3707 Gordon Parry and Susan P. Hawkes Detection of an early surface change during oncogenic transformation (chicken embryo fibroblasts/Rous sarcoma virus!

temperature-sensitive mutant/ffluorescamine/fluorescence)

3708-3712 Dana L. Diedrich and Carl A. Schnaitman Lysyl-derived aldehydes in outer membrane proteins of Escherichia coli (allysine/cx-aminoadipic acid 3-semialdehyde)

3713-3716 Shimon Schuldiner, Hanna Fishkes, and Baruch I. Kanner Role of a transmembrane pH gradient in epinephrine transport by chromaffin granule membrane vesicles (catecholamines/active

transport/chromaffin vesicles/ATPase)

3717-3721 Benjamin C. Stark, Ryszard Kole, Emma J. Bowman, and Sidney Altman Ribonuclease P: An enzy:me with an essential RNA component (endoribonuclease/precursor tRNA substratesiRNA subunit)

3722-3726 L. F. Thompson, R. C. Willis, J. W. Stoop, and J. E. Seegmiller Purine metabolism in cultured human fibroblasts derived from paLtients deficient in hypoxanthine phosphoribosyltransferase,

purine nucleoside phosphorylase, or adenosine deaminase (Lesch-Nyhan syndrome/immunodeficiency)

3727-3731 Lydia Villa-Komaroff, Argiris Efstratiadis, Stephanie Broome, Peter Lomedico, Richard Tizard, Stephen P. Naber, William L. Chick, and Walter Gilbert

A bacterial clone synthesizing proinsulin (rat preproinsulin/cDNA cloning/solid-phase radioimmunoassay/DNA sequence/fused proteins)

3732-3736 R. P. Ambler and G. K. Scott Partial amino acid sequence of penicillinase coded by Escherichia coli plasmid R6K (f-lactamase/protein homology)

3737-3741 J. Gregor Sutcliffe Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322 (protein sequence/secretion signal/

f3-lactamase/DNA chemistry)

3742-3746 K. Ugurbil, T. R. Brown, J. A. Den Hollander, P. Glynn, and R. G. Shulman High-resolution 13C nuclear magnetic resonance studies of glucose metabolism in Escherichia coli (glycolysis/glucose utilization/

anomeric specificity/anaerobic/aerobic)

4067 Konrad Sandhoff and Bernhard Pallmann Membrane-bound neuraminidase from calf brain: Regulation of oligosialoganglioside degradation by membrane fluidity and

membrane components (Correction) (lipophilic and hydrophilic substrates/inhibitors/general anesthetics/ fluorescence depolarization)

4067 Douglas A. Lappi, Wolfgang Kapmeyer, Janice M. Beglau, and Nathan 0. Kaplan The disulfide bond connecting the chains of ricin (Correction) (A--B chain complex/reduction of ricin/protein synthesis

inhibition/ultracentrifugation/ricin purification)

BIOPHYSICS

3747-3750 V. S. Sharma, J. F. Geibel, and H. M. Ranney "Tension" on heme by the proximal base and ligand reactivity: Conclusions drawn from model compounds for the reaction of

hemoglobin (kinetics/cooperativity/a,fd-chain differences)

3751-3755 Hansgeorg Schindler and Jurg P. Rosenbusch Matrix protein from Escherichia coli outer membranes forms voltage-controlled channels in lipid bilayers (association of vesicle-

spread monolayers/quantitative protein incorporation/negative resistance/protein-protein interaction/glucose permeability)

3756-3760 Julius Bernhardt and Eberhard Neumann Kinetic analysis of receptor-controlled tracer efflux from sealed membrane fragments (acetylcholine receptor/excitable

membranes/pharmacological desensitization)

CELL BIOLOGY

3761-3765 J. Carl Barrett and Paul 0. P. Ts'o Evidence for the progressive nature of neoplastic transformation in vitro (chemical carcinogenesis/Syrian hamster/anchorage

independence/fibrinolytic activity)

3766-3770 Peter S. Coleman, Anthony J. Ewell, and Robert A. Good Retention of susceptibility to mitogens after direct dansylation of viable human lymphocytes (plasma membrane/fluorescent

probe/lectin)

3771-3775 J. Michael Marcum, John R. Dedman, B. R. Brinkley, and Anthony R. Means Control of microtubule assembly-disassembly by calcium-dependent regulator protein (immunofluorescence/calcium-binding.

proteins/mitosis )

3776-3780 Ahmed unny Therwath and Klaus Scherrer Post-transcriptional suppression of globin gene expression in cells transformed by avian erythroblastosis virus (oncornavirus/

hemoglobin genes/mRNA formation/post-transcriptional regulation)

3781-3785 Joseph Lotem and Leo Sachs In vivo induction of normal differentiation in myeloid leukemic cells (macrophage- and granulocyte-inducing protein/syngeneic

and nude mice/cyclophosphamide/in vivo regulation/mutants)

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