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Functional Neuroimaging Lab @ IIT Alice Bertero, Carola Canella, Ludovico Coletta, Alessia De Felice, Alberto Galbusera, Daniel Gutierrez*, Adam Liška, Federico Rocchi, Marco Pagani Principal investigator: Alessandro Gozzi * Co-supervision with Stefano Panzeri, Neural Computation Lab Research Opportunities for Master Students Research internships available on fMRI connectivity of the mouse brain (Jan 2019) Master thesis projects in the field of functional and structural brain mapping One Post Doc position available in 2018 (funded by NARSAD) If interested, contact [email protected] Neural basis of functional dysconnectivity in autism Functional organization of the mouse brain 16p11.2 deletion impairs prefrontal connectivity in humans and mice Cntnap2 +/+ Cntnap2 -/- Cntnap2 +/+ > Cntnap2 -/- Rs Rs Cg PrL PrL Rs A B Schwarz and Gozzi, 2015, Neuroimage PtA Cg Rs IPL Cg Rs/PCC Human Mouse Liska et al., 2015 Rs PFC aCg Mouse Human Explanatory Gap Syndromic ASD mutations Mouse mutant models Cellular biology/physiology Neural systems Neural systems Liska & Gozzi, Front Neurosci 2016 r score Rs1 Rs2 Rs3 Rs4 Cg1 Cg2 Cg3 Cg4 0.0 0.1 0.2 0.3 +/+ + /- * PFC connectivity 10 20 30 40 0.0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 Frequency [Hz] PFC-RS coherence +/+ +/- 16p11.2 +/+ PFC PFC PFC Rs A B PFC 16p11.2 +/- PFC Rs Rs Rs 2 t-statistics 8 C D delta theta alpha beta 0.0 0.1 0.2 0.3 0.4 0.5 PFC-RS coherence +/+ +/- * Modulation of fMRI connectivity: Chemogenetic-fMRI A B 5 2 t Seed Global connectivity 16p11.2 < TD 16p11.2 < TD Connectivity to mPFC Liska et al. Cer Cortex (2017) Bertero et al. In preparation A Cb TeA Cg Ent V1 B Giorgi et al. Cell Reports (2017)
