Functional Neuroimaging Lab @ IITAlice Bertero, Carola Canella, Ludovico Coletta, Alessia De Felice, Alberto Galbusera,
Daniel Gutierrez*, Adam Liška, Federico Rocchi, Marco Pagani
Principal investigator: Alessandro Gozzi * Co-supervision with Stefano Panzeri, Neural Computation Lab
Research Opportunities for Master Students
Research internships available on fMRI connectivity of the mouse brain (Jan 2019) Master thesis projects in the field of functional and structural brain mapping One Post Doc position available in 2018 (funded by NARSAD) If interested, contact [email protected]
Neural basis of functional dysconnectivity in autism
Functional organization of the mouse brain 16p11.2 deletion impairs prefrontal connectivity in humans and mice
A
Cntnap2+/+ Cntnap2-/- Cntnap2+/+ > Cntnap2-/-
Rs RsCg
PrL PrL Rs
2 6Z
Pt Pt RsCg
A
B
C
4 10Z
Au/TeAAu/TeA
Cg
Rs
vHPCvHPC IL
D
E
Seed mapping (PCC/Rs)
Schwarz and Gozzi, 2015, Neuroimage
a b
c
PtA
Cg
Rs
IPL
Cg
Rs/PCC
Human Mouse
Human Mouse
Liska et al., 2015
RsPFC
aCg
Mouse
Human
ExplanatoryGap
Syndromic ASD mutations
Mouse mutant models
Cellular biology/physiology
Neural systems
Neural systems
Liska & Gozzi, Front Neurosci 2016
r s
co
re
Rs1
Rs2
Rs3
Rs4
Cg
1
Cg
2
Cg
3
Cg
4
0 .0
0 .1
0 .2
0 .3+ /+
+ / -
*
P F C c o n n e c tiv ity
1 0 2 0 3 0 4 0
0 .0
0 .1
0 .2
0 .3
0 .4
0 .5
0 .6
0 .7
F re q u e n c y [H z ]
PF
C-R
S c
oh
ere
nc
e
+ /+
+ /-
16p11.2+/+
PFCPFC
PFC
Rs
A B
PFC
16p11.2+/-
PFC
Rs
Rs Rs
2t-statistics
8
C D
d e lta th e ta a lp h a b e ta
0 .0
0 .1
0 .2
0 .3
0 .4
0 .5
PF
C-R
S c
oh
ere
nc
e
+ /+
+ /-*
Modulation of fMRI connectivity: Chemogenetic-fMRI
A B
5
2
tSeed
Global connectivity
16p11.2 < TD 16p11.2 < TD
Connectivity to mPFC
Liska et al. Cer Cortex (2017)
Bertero et al. In preparation
A
Cb
TeA
Cg
Ent
V1
B
Giorgi et al. Cell Reports (2017)
