1.Which of the following anti-arrhythmic drug is having Iodine?

a. Disopyramide b. Flecainide c. Amiodarone d. Quinidine

2. The quality of Coca leaves is mainly dependent on which of the following

constituents?

a. Cocaine b. Truxilline c. Ecgonine d. Cinnamyl cocaine

3. CH3O- Na+ + CH3Cl - CH3 - O - CH3 + NaCl

The above reaction is an example for which of the following?

a. Williamson reaction b. Clemmenson reaction

c. Wuotz's reaction d. Reformatsky reaction

4. Which of the following gelatine concentration is used to determine the

viscosity of gelatine used for the preparation of soft gelatine capsules?

a. 6 2/3 % b. 7 2/3% c. 5 2/3 % d. 6 3/4%

5. Which of the following group is detected by using Herzig Meyer method?

a. Alkyl group b. Hydroxy group c. Alkoxy group d. N-alkyl group

6. Which of the following drug blocks the sodium channel and dissociates

slowly?

a. Quinidine b. Lignocaine c. Flecainide d. Procainamide

7. According to Drugs and Cosmetics act, List of substances that should be

sold by retail only on prescription of registered medical practitioner is given

in which of the following Schedule?

a. Schedule 'H' b. Schedule 'V' c. Schedule 'X' d. Schedule 'Q'

8. In HPLC, which pump gives a mobile phase flow rate dependent on column

permeability?

a. Constant pressure pumps b. Constant displacement pumps

c. Reciprocating pumps d. Pneumatic pumps

9. Which of the following organism is the Source for amphotericin?

a. Streptomyces immodosus b. Streptomyces nodosus

c. Streptomyces griseus d. Streptomyces aureofaciens

10. Which of the following drug produces gastric irritation after

micronization?

a. Phenobarbital b. Tetracycline

c. Erythromycin d. Nitrofurantoin

11. Adult dose of a drug is 150 mg/kg and the drug is available as tablets of 2

mg strength. Calculate the dosed required for a boy of age 14 yrs and weight

of 35 kg?

a. 74.9 mg b. 78 mg c. 82 mg d. 80 mg

12. Which of the following method is used to measure respiratory efficiency of

cells in cell culture?

a. Fluroscein Diacetate method b. Reduction of tetrazolium salts

c. Evan's blue method d. Calcofluor white method

13. Which of the following Dopaminergic agonist used in the treatment of

Parkinsonism?

a. Levodopa b. Carbidopa c. Mirtazapine d. Ropinirole

14. What is the principle involved in the VDRL test?

a. Agglutination b. Precipitation c. Flocculation d. Opsonisation

15. Prazocine is a derivative of which of the following?

a. Quinazoline b. Phthalazine c. Quinoline d. Isoquinoline

16. Bladder toxicity is the side effect of which of the following drug?

a. Vincristine b. Cyclophosphamide c. 5-Flouro Uracil d. Doxorubicin

17. Which of the following is a prototype of Sedative?

a. Chloral hydrate b. Chloral c. Chloroquine d. Chlorpheniramie

18. If the half life for decomposition of a drug is 12 hrs, how long will it take

for 125 mg of the drug to decompose by 30 %? Assume that the drug follows

first order kinetics at constant temperature.

a. 6.1 hr b. 8.2 hr c. 7.9 hr d. 5.5 hr

19. Which of the following is used as Cuticle Remover?

a. Nitrocellulose b. Mineral oil

c. Trisodium phosphate d. Acetoglyceride

20. Which of the following amino acid is present in Captopril?

a. Glycine b. Cysteine

c. Proline d. Para Amino benzoic acid

21. Which of the following is the biosynthetic origin for an amino alkaloid

Ephedrine?

a. Phenyl alanine and Ornithine b. Phenyl alanine and Pyruvic acid

c. Histidine and Threonine d. Tyrosine and Dihydroxy phenyl alanine

23. Which of the following is the responsible for prolonged QT interval?

a. Hypokalemia b. Tricyclic anti-depressants

c. Hypercalcemia d. Left ventricular hypertrophy

24. Metastable peaks are always present at

a. Even mass numbers b. Integral mass numbers

c. Odd mass d.Non-integral mass

25. Which of the following antacid produces constipation?

a. Sodium citrate b. Magnesium hydroxide

c. Magnesium trisilicate d. Aluminium hydroxide gel

26. Calculate the amount of sodium chloride required to make 1.5 % solution of

pilocarpine HCl isotonic with tear secretion? (Freezing point depression of 1 %

pilocarpine HCl is - 12C and that of sodium chloride is - 0.576C).

a. 0.564 % w/v b. 0.712 % w/v c. 0.224 % w/v d. 0.693 % w/v

27. Lecithin is incorporated in shampoos as

a. Conditioning agent b.Clarifying agent

c. Opacifying agent d. pH adjusting agent

28. What is the % of ionisation of a drug with pKa 5 at pH 8?

a. 99.9 % b. 99.99 % c. 90 % d. 99 %

29. Which of the following antihypertensive drug used in the treatment of

alopecia?

a. Minoxidil b. Diazoxide c. Reserpine d. Hydralazine

30. What is the use of infusion of Tulsi leaves?

a. Insecticidal b. Spasmolytic c. Stomachic d. Stimulant

31. The conductivity of the solution of an electrolyte is

a. Independent of Temperature b. Dependent of Temperature

c. Dependent of Both Temperature and Pressure d. Dependent of Pressure applied

32. Which of the following is the active metabolite of Quinidine?

a. 3-Hydroxy quinidine b. 3-hydroxy quinine

c. 2-Hydroxy quinidine d. 2-hydroxy quinine

33. Which of the following drug is aldehyde Dehydrogenase inhibitor?

a. Sedative b. Hypnotic

c. Disulfiram d. Methyl alcohol

34. Which of the following method is suitable for the sterilization of bone and

tissue transplants?

a. Ionizing radiation b. Gaseous sterilization

c. Dry heat sterilization d. Moist heat sterilization

35. What is the location of chlorine in Chloroquine?

a. 4 b. 5 c. 6 d. 7

36. Which of the following amino acids contains imidazole ring?

a. Histidine b. Asparagine c. Tryptophan d. Proline

37. The Allergic reaction caused by tetracycline is

a. Decrease in B.P. b. Dermatitis c. Urticaria d. Leucopenia

38. What is 'X'?

a. b. c. d.

39. Which of the following is not an example for synthetic hair dye?

a. Para toluene diamine b. p-phenylenediamine

c. Sulpho-ortho-amino phenol d. Lead acetate with precipitated sulphur

40. Which of the following drying method under controlled conditions results

in changes in chemical composition?

a. Processing b. Mulching c. Curing d. Fermentation

41. Which of the following is used in the Monteux test?

a. Old tuberculin b. Diphtheria toxin

c. Serum antigen d. Polysaccharide antigen

42. Which of the following is the starting material for the biosynthesis of l-

Hyoscyamine?

a. Tyrosine b. Alanine c. Valine d. Phenyl alanine

43. How much sodium chloride is required to render 100 ml of a 1 % solution

of apomorphine hydrochloride isotonic with blood serum? (Freezing point

depression of 1 % solution of drug is - 0.08C and that of sodium chloride is -

0.58C).

a. 0.76 % b. 0.89 % c. 0.96 % d. 1.86 %

44. Which of the following antibiotics acts by damaging cytoplasmic

membrane?

a. Nevirapine b. Quinolones c. Colistin d. Vancomycin

45. Which of the following is an example for the transport protein?

a. Keratin b. Myosin c. Pepsin d. Albumin

47. What is the drug of choice in ringworm infections? a. Albendazole

48. DPT is an example for a. Active acquired immunity

49. Which of the following member is an ex-officio member of the State

Pharmacy council? b. Chief Administrative medical officer of the State

50. Which of the following antidote antagonize the peripheral action of

Organophosphorus compounds?a. Atropine

51. Which of the following Quinoline derivatives is used in the treatment of

bacillary dysentery?a. Nalidixic acid

52. Polarogram of a solution containing an electro-reducible substance is

obtained by plotting a. Potential Vs Volume

53. Which of the following is used for the assessment of growth in suspension

culture?a. Packed cell volume

54. Which of the following is the synthetic membrane? d. n – Octanol

55. Calculate bulk density of paracetamol granules having a true density of

1.8 and % porosity of 60? c. 0.72

56. How many number of ester bonds present in phospholipids?a. 4

57. Which of the following is the synthetic derivative of Opium alkaloid?c.

Pethidine

58. Statto - Oto method is used for the isolation of which of the following?b.

Glycosides

59. Which of the following disease susceptibility can be determined by Shick test?

b. Diphtheria

60. Monoamine Oxidase is located in which of the following?a. Mitochondria

61. Which of the following is the IUPAC name for Progesterone? d. Pregn-4-ene-

3, 20-dione

62. Which of the following is an example for natural emulsifying agent of animal

origin?d. Gelatine

63. Which of the following alkaloidal drug is having pseudo parenchyma?d. Ergot

64. Basophiles are having receptors for which of the following antibodies?d. Ig E

65. Which of the following is an example for Thermal Conductivity Detector?c.

Katharometer

66. Which of the following metabolites usually undergo enterohepatic circulation?

a. Glucuronate conjugates

67. Which of the following semipermeable membrane used in haemodialysis?a.

Cellophane

68. Which part of the umbelliferous fruits is having high content of volatile oils?a.

Mesocarp

69. Which of the following Glutamate antagonist used in Alzheimer's disease?c.

Memantine

70. Mass spectra is usually obtained bya. Electron impact

71. Which of the following is the active metabolite of Phenacitin?c. p - Hydroxy

phenyl acetanilide

72. Which of the following toxins are produced by E.coli?b. Endotoxins

73. Which of the following are identified by using Borax test?b. Barbaloins

74. Iron content of gelatine used for the preparation of soft capsule should not be

more than a. 15 ppm

75. Which of the following antihypertensive drugs acts as MAO inhibitor?a.

Tranylcypromone

76. Pantothenic acid is a constituent of the coenzyme involved in c. Acetylation

77. What is the metabolic advantage of Procainamide compared to Procaine?b. It

does not undergo hydrolysis by esterase

78. Which of the following technique single step purification of sample is

achieved?c. Gel filtration

79. Which of the following is readily used for the filling of pelletized or granular

material into Capsules?b. Rotofil

80. Where biological and microbiological tests are conducted?d. Kasauli

81. Which among the following is Gyrase inhibitor? c. Norfloxacin

82. Calculate the amount of 95 % alcohol required to prepare 400 ml of 45 %

alcohol?a. 190 ml

83. Which of the following medium is used for differentiation of lactose and non -

lactose fermentors?a. Mac Conkey's medium

84. Which of the following odour is developed when ergot powder is treated with

sodium hydroxide?d. Triethyl amine

85. Betamethazone and Dextromethazone are a. Epimers c. Optical isomers d.

Both a and c

86. LAL (Limulus Amebocyte Lysate) isa. An in vitro test for detecting

pyrogenic endotoxins

87. Which of the following allied drugs of Senega does not contain Saponin

c. Polygala chinesis 

88. How many signals are produced by CH3-CH2 - CH2 -CO-CH2 -CH3 in NMR

spectroscopy?d. 2

89. Which of the following hormone is used for confirmation of pregnency? a.

HCG

90. In Elisa technique, the antibodies are labelled by b. Alkaline phosphate

91. Which of the following is also known as 11 - Desmethoxy Reserpine? b.

Deserpidine

92. Which of the following drug is not bound to Warfarin binding sites? a. Phenyl

butazone b. Sulfamethizolec. Bilirubin d. Ketoprofen

93.Is the entomer of Succinyl choline, which is b. Anti isomer

94. What is the drug of choice in Chloramphenicol resistant typhoid d.

Fluoroquinolones

95. Which of the following drug is designed as prodrug for improved taste?b.

Clindamycin palmitate ester

96. SAR studies on v - antagonists is mainly aimed at a. Selectivity

97. Which of the following drug inhibits the Prolactin level? b. Dopamine

98. Which of the following is obtained by fusion of Morphine with potassium

hydroxide? c. Proto Catechuic acid

99. A solution of drug was prepared freshly at a concentration of 300 mg/ml. After

25 days of storage at 25 OC, the drug concentration in the solution was found to be

120 mg/ml. The drug assumed to undergo zero-order kinetics. Calculate the

reaction rate constant?

a. 7.2 mg/ml/day b. 62.5 mg/ml/day c. 0.72 mg/ml/day d. 6.25 mg/ml/day

KEY:

1 c 2 c 3 A 4 a 5 d 6 c 7 a 8 a 9 b 10 d

11 a 12 b 13 D 14 b 15 a 16 b 17 b 18 a 19 c 20 c

21 b 23 A 24 d 25 d 26 a 27 a 28 a 29 a 30 c

31 b 32 a 33 c 34 a 35 d 36 a 37 b 38 b 39 d 40 c

41 a 42 d 43 a 44 c 45 d 47 a 48 a 49 b 50 a

51 a 52 a 53 a 54 d 55 c 56 a 57 c 58 b 59 b 60 a

61 d 62 d 63 d 64 d 65 c 66 a 67 a 68 a 69 c 70 a

71 c 72 b 73 b 74 a 75 a 76 c 77 b 78 c 79 b 80 d

81 c 82 a 83 a 84 d 85 d 86 a 87 c 88 d 89 a 90 b

91 b 92 d 93 b 94 d 95 b 96 a 97 b 98 c 99 a

1) The following gibberalin derivative is known as gibberalic acid…………a) GA1 b) GA2 c) GA3 d) GA42) The following is the precursor for the synthesis of Dhurrin in sikkimic acid pathway…………..a) Phenylalanine b) Tyrosine c) Linamarin d) Lotuustralin3) Multicellular branched covering peltate trichomes are characteristic

for…………..a) Hammelis b) Humulus c) Verbascum Thapsus d) All of the above4) Ranunculaceous stomata is the characteristic for ……..a) Buchu b) Digitalis c) Lobelia d) All of the above5) Moisture content limit for digitalis should not be more than……a) 10 b) 05 c) 08 d) 156) The fluorescence exhibited by rhubarb under UV light is…………….a) Purple blue b) Whitish blue c) Viloet d) Mauve

7) For the measurement of hypoglycemic activity, the following herbal

extract is used…………..a) karela b) Jambul c) Fenugreek d) All of the above8) The total aerobic microbial load per gram of material ready for internal use is………….a) 105 b) 102 c) 10 d) 1039) Outgrowth arista( awn) is found in following drug……a) Cardamom b) castor c) Nutmeg d) Stropanthus10) The cathartic principle in momordica charantia is…….a) Charantin b) Momordicin c) saponin d) Glucoside11) From the following which one is immunomodulator drug,,,,,,,,,,,,,a) Brahmi b) Jatamansi c) Ginseng d) All of the above12) Rhytidoma is the characteristic for……..a) Gokhru b) Rattle snake root c) Quillaia d)Brahmi13) The bitter taste of gentiana lutea is due to…….a) Gentisin b) Gentianine c) Amarogentin d) gentiopicrin14) The following is the example of non-drying oil………..

a) Oilve oil b) Peanut oil c) Almond oil d) All of the above15) Badouin's test is given by…………….

a) Sesame oil b)Oilve oil c) Peanut oil d) Almond oil 16) Carr price reaction is positive in case of……………a) Vit.A b) Vit.B c) Vit.D d) Vit.B717) The following variety of cardamom does not show rugae among all the varieties…………..a) Allepy cardamom b) Mysore cardamom c) Korarima cardamom d) Malabar cardamom

18) The following microscopical characters are true for fennel except…a) Anomocytic stomatab) Lignified and reticulate parenchymac) Rossete crystals of ca-oxalated) Trichomes and starch grains are absent19) The outgrowth of nutmeg contains amylodextrin which gives following colour with iodine…………

a) red colour b) Blue colour c) Pink colour d) white colour20) The following microscopical characters are false in case of Clove except one….and it is….a) Clove contains diacytic stomatab) Clove contains starchc) Scizogenous oil glandsd) It contains anomocytic stomata21) Ca-oxalate crystals and starch grains are absent in…..p) Fennel q) Stropanthus r) Nux-vomica s) Physostigmaa) p,q b) p,r c) q,s d) r,s22) The following variety is the commercial source of reserpine…………..a) R.tetraphylla b) R.Vomitoria c) R.serpentina d) R.densiflora23) Vitali-morin reaction is positive in case of………a) Tropane alkaloids b) Quinoline c) Isoquinoline d) Purine alkaloids24) Sunken trichomes and sunken stomata are present respectively in following drug……p) Ephedra q) Colchicum r) Lobelia s) Gloriosaa) p,r b) r,p c) q,r d) p,q25) The IUPAC name for Prazepam is……a) 7-chloro-1-methyl-1,3-dihydro-5-phenyl-2H-benzodiazepine-2-oneb) 8-chloro-1-( Cyclobutylmethyl)-1,3-dihydro-5-phenyl-2H-benzodiazepine-2-onec) 7-chloro-1-( Cyclopropylmethyl)-1,3-dihydro-5-phenyl-2H-benzodiazepine-2-oned) 8-chloro-1-( Cyclopropylmethyl)-1,3-dihydro-5-phenyl-2H-benzodiazepine-2-one26) Buspirone contain following ring system……….a) Spiran b) Piperazine c) Pyrimidine d) All of the above

2)27) 4-[3-[2-( trisfluoromethyl) phenazin-10-yl]propyl]-1-piperazineethanol tends for……………..a) Perphenazine b) Fluphenazine c) Acetophenazine d) Trifluoperazine

3)28) 6-[ 2,3-dichloro phenyl)]-3,5-diamino triazine tends for following category of drug……………..a) Anti-depressant b) Anti-psychotic c) Anxiolytic drug d) Anti-epileptic drug

4)29) The following is CNS stimulant drug…..a) Mazindol b) Phendimetrazine c) Pemoline d) All of the above

5)30) The tricyclic anti-depressant drug trazodone contain following ring system…………a) Piperazine b) Triazole c) Pyridine d) All of the above

6)31) The following is true for dobutamine except….a) B1- receptor agonistb) it is used in cardiogenic shockc) (-) enantiomer is potent α1 agonistd) (-) enantiomer is potent α2 agonist

7)32) The following drugs are used in benign prostatic hypertrophy ( BPH) …………….p) Tamsulosin q) Clonidine r) Mifepristone s) Finasteridea) p,r b) p,q c) p,s d) q,r

8)33) The mechanism of corynanthine is……………a) Selective α2 receptor antagonistb) Selective α1 receptor antagonistc) non-selective α receptor antagonistd) Selective β1-receptor agonist

9)34) Occulomucocutaneous syndrome is the side effect of following

drug……a) Metoprolol b) Practolol c) Albuterol d) Atenolol

10)35) The following drug is safe in hypertension in pragnency ……………p) Methyl dopa q) Labeatalol r) Carvediol s) Ritodrinea) p,s b) q,s c) p,q d) q,r

11)36) The following is the quinazoline ring containing drug………………..a) Prazosin b) Methaqualone c) Metolazone d) All of the above

12)37) The IUPAC name for amiloride is…………….a) 3,4-diamino-N-( aminoiminomethyl)-6-chloropyrazine carboxamideb) 3,4-diamino-N-( aminoiminomethyl)-6-chloropiperazine carboxamidec) 3,5-diamino-N-( aminoiminomethyl)-6-chloropyrazine carboxamided) 3,5-diamino-N-( aminoiminomethyl)-6-chloropyridine carboxamide

13)38) 1-methyl-2-( 2,6-xylyloxy)-ethylamine is the IUPAC name for……………….a) Lidocaine b) Mexiletine c) Encainide d) Flecainide

14)39) The following drug is only acting as arterial vasodilator………….a) Hydralazine b) Na-nitroprusside c) Diazoxide d) Minoxidil

15)40) Among all the sulfonyl ureas, the following drug is having longer duration of action…..a) Tolbutamide b) Chlorpropamide c) Acetohexamide d) Tolazamide

16)41) To filter the slurries containing the solids not more than 5 %, the following filter is used………..a) Filterpress b) Filterleaf c) Meta fliter d) Membrane filter

17)42) If carr's index is 23-35 then flow is ……………a) Excellent b) Fair to passable c) Poor d) Extremely poor

18)43) If the PKa of Phenobarbitone is 7.4.what fraction of drug would be

ionized at pH 8.4?..............a) 0.01 b) 0.50 c) 0.90 d) 1.00

19)44) The following is the example of cationic surfactant……………………a) Benzalkonium chloride b) Polysorbate 80 c) SLS d) Sorbitan monooleate

20)45) The type of particle diameter that is obtained by microscopic method of evaluation is………………..a) Projected b) Stokes' c) Volume d) Volume-surface

21)46) HEPA filters are widely used in ………………..a) Autoclaves b) Laminar air flow hoods c) Gas sterilizers d) Oxygen masks

22)47) Inversion sucrose in syrup due to heat is known as…………….a) Isomerization b) Epimerization c) Tautomeriation d) caramelization

23)48) carnauba wax is used in the following step of sugar coating of tablet:a) Seal coating b) Polishing c) Sub-coating d) Syrup coating

24)49) One of the following diluent may discolour in the presence of amine containing drugs:a) Avicel b) DCP c) Lactose d) Talc

25)50) Cam tracks are used in tablet formulation for………………a) Feeding the granules b) Fixing the shapec) Compressing the granules d) Guiding the movement of punches

26)51) Non-ionic surfactant vesicles relates to……….a) Liposomes b) Niosomes c) Nanoparticles d) a and b both

27)52) Water insoluble coating materials used for microencapsulation include……………a) Ethyl cellulose b) Polyethylene c) Polyamide d) All of the above

28)53) Schedule U1 tends for……………………….a) Manufacturing and analytical records of drugsb) Manufacturing and analytical records of cosmeticsc) Standards for patent or proprietary medicinesd) List of drugs marketed under generic name only

29)54) The test which is useful for the identification of M. tuberculosis…………….a) Haemolysis b) Fermentation with sugar c) Gram-staining d) Zeihl-nelson staining

30)55) The following type of antigen associated with capsules…………..a) H-antigens b) 0-antigens c) V-antigens d) K-antigens

31)56) Colchicine when treated with 70 % H2SO4 or HCL gives following colour…………………a) Red colour b) Blue colour c) Green colour d) yellow colour

32)57) Quinine gives following positive test……………a) Herpathite test b) Thaleoquin test c) Rosequin test d) All of the above

33)58) Schilber reagent is used for the detection of……………..a) Glycosides b) Volatile oils c) Alkaloids d) Tannins

34)59) Noller test is used for the detection of………………..a) ) Glycosides b) Volatile oils c) Alkaloids d) Tannins

35)60) Vit.requirement for microorganism Sytreptococcus pyogenes is…… a) Tryptophan b) Glutathione c) Riboflavin d) Vit.B12

36)61) The test organism used for validation of filtration sterilization is……..a) Serratia marscenes b) Pseudomonas dimunata c) Vibrio percolans d) All of the above

37)62) The biological source for Cycloserine is…………a) S.Orchidaceus b) S.garyphyllus c) S.lavandulus d) All of the above

38)63) Which of the following drug used in digitalis induced arrhythmias?.............a) Verapamil b) Phenytoin c) Flecainide d) Procainamide

39)64) Aspartame is chemically…………….a) Methyl ester of aspartic acid and phenylalanineb) Methyl ester of phenylalanine and aspartic acidc) Ethyl ester of phenyl alanine and aspartic acidd) Ethyl ester of aspartic acid and phenyl alanine

40)65) Which of the following is used as a bulk property detector in HPLC?a) UV-visible detector b) Diode array detector c) Refractive index detector d) Fluorescence detector

41)66) Which of the following drug is biosynthesized from Lysine?a) Pilocarpus b) Asthma weed c) Aconite d) Holarhhena

42)67) Sugar coated tablet having disintegration time is……………a) 15 min b) 60 min c) 30 min d) 45 min

43)68) Drugs used in the treatment of Insulinoma is……………a) Chlorambucil b) Tolbutamide c) Streptozotocin d) Melphalan

44)69) Which of the following used as stabilizer in the parenteral products………..?a) Na sulfate b) Na caprylate c) Na desoxycholate d) Na CMC

45)70) Most commonly used radiation source in atomic absorption spectroscopy is…………….a) Tungsten lamp b) Xenon discharge lamp c) Hollow cathode lamp d) Mercury vapour lamp

46)71) Anorgasmia side effect produced by…………..a) Selective serotonin reuptake inhibitorb) Tricyclic antidepressantc) Monoamine oxidase inhibitorsd) All of the above

47)72) Which of the following drug is contraindicated in type IIa hyperlipoproteinamia……….?a) Probucol b) Colestipol c) Acipimox d) Fish oil73) Mediastinal fibrosis side effects produced by……………..a) Propranolol b) Sumatriptan c) Methysergide d) Cyproheptadine

48)74) Number of peaks given by 1H NMR spectrum of P-xylene is…………..a) 4 b) 1 c) 2 d) 3

49)75) USP dissolution apparatus 4 used for ……………a) Capsule b) Tablet c) Low solubility of drugs d) Emulsion

50)76) The heterocyclic ring present in dipyridamole is………..a) Pyridine b) Piperidine c) Pyarazine d) Piperazine

51)77) Which form no is used for import of biological drugs( C/C1)…………a) 9 b) 12-A c) 11-A d) 24-A

52)78) Paper chromatography is based on…………….a) Adsorption b) Exclusion c) Affinity d) Partition

53)79) α-[ 2-( diisopropylamino) ethyl]-α-phenyl-2-pyridine acetamide is……………..a) Amiodarone b) Mexiletine c) Disopyramide d) Procainamide

54)80) Which of the following is non-competitive inhibitor of citric acid cycle enzyme called α-ketoglutarate dehydrogenase?a) Fluoroacetate b) Arsenite c) Melonate d) Lithium

55)81) Imipenam is…………p) Obtained from chromobacterium violaceumq) It is given with cilastatinr) It is monocyclics) Obtained from streptomyces cattelyaa) p,q b) q,s c) p,r d) r,s

56)82) Riedal-walker test ……p) Measure the effectiveness of antibioticsq) test organism E.colir) Test organism salmonella typhis) Measure effectiveness of anticepticsa) p,q b) q,s c) p,r d) r,s

57)83) Which of the following problems associated with glass containers?p) Weathering q) Corrosion problem r) Flaking s) Breathinga) p,q b) p,r c) p,s d) r,s

58)84) Which transitions are given by benzoic acid under UV spectra………………p) n π* q) π π* r) n δ* s) δ δ*a) q,r b) r,s c) p,r d) p,q

59)85) Which of the following bio-chemical tests given by phenolic group containing amino acids……..?p) Nin-hydrine reaction q) Nitroprusside reaction r) Millon's reaction s) Folin- coicalteau's testa) p,s b) q,r c) r,s d) p,r

60)86) In aerosol container, gasket is made up of…………………p) Buna-N q) Neoprine rubber r) Nylon s) Delrina) p,q b) q,r c) p,s d) p,r

61)Common data questions:

87) Sex pheromones used as………..a) Sex hormones b) Fertilizers c) Plant growth regulators d) Pest control agent

62)88) Example of sex pheromones is………..a) Nitrogen b) testosterone c) 7,8-epoxy 2- methylloctadecane d) Abscisic acid

63)89) Starting material for the synthesis of cinchocaine is………………a) o- toluidine b) Picolinic acid c) Isatin d γ- picoline

64)90) The IUPAC name for cinchocaine is………….a) 2-butoxy-N-[ 2-( dimethylamino)methyl]-quinoline-4-carboxamideb) 2-butoxy-N-[ 2-( diethylamino)ethyl]-quinoline-4-carboxamidec) 2-ethoxy-N-[ 2-( dimethylamino)ethyl]-quinoline-4-carboxamided) 2-ethoxy-N-[ 2-( diethylamino)methyl]-quinoline-4-carboxamide

65)In a formulation laboratory , tablet is to be formulated,the core tablet has bad taste and required protection from moisture.The Tablet should also deliver the drug for local action in intestine:91) Suggest suitable method………a) Sugar coating b) Film coating c) Enteric coating d) Sub-coating

66)92) Choose the correct coating material………….a) Sugar b) Acacia c) EC d) Acrylates

67)Linked questions: Triamterine is diuretic drug.it is potassium sparing diuretic……….93) It contains which is containing heterocyclic ring?a) Quinoline b) Quinazoline c) Pteridine d) Pyrimidine

68)94) It's mechanism of action is…………..a) Aldosterine antagonist b) Block luminal Na+ channel c) Block Na+/K+/2Cl- tranporterd) Block Na+/Cl- transport

69)95) Pyrilamine is antihistaminic drug…………..Pyrilamine is chemically………………a) Amino alkyl ether b) Imidazole analogue c) Ethylene diamines d) Propylamines

70)96) Pyrilamine maleate is assayed as per IP by titrating with a) 0.1 M NaOH b) 0.1 M Perchloric acid c) 0.1 M HCL d) 0.1 M silver nitrate

71)As per the woodward-fieser rule,the absorption maxima of the compound shown is calculated from the base value and the ring Residue values………….

97) Base value is…….a) 215 nm b) 253 nm c) 240 nm d) 217 nm98) Absorption maxima is…………a) 220 nm b) 230 nm c) 258 nm d) 268 nm

72)An organic compound " X" has an absorption maxima at 217 nm.It's Emax is 16,000.The absorbance is 0.64 when the cell length is 1 cm..The decomposition of drug in aqueous acid solution was found to follow first order reaction.The initial concentration was found To be 0.056 M.The initial Concentration was found to be 0.056 M.The concentration after a period of 12 hrs was 4.10×102- Moles/liter.The reaction rate constant is 0.02599 hr1-99) What is the quantity of the drug remaining undecomposed after 8 hrs……..?a) 0.455 moles/litre b) 0.25 moles/ litre c)0.0455 moles/litre d) 0.10 moles/litre

73)100) What is the amount of drug deteriorated during the period of 24 hrs?a) 0.026 moles/litre b) 0.0026 moles/litre c) 0.03 moles/litre d) 0.053 moles/litre  

Answersheet

1 c 21 b 41 b 61 d 81 b2 b 22 b 42 c 62 d 82 d3 b 23 a 43 c 63 b 83 b4 d 24 b 44 a 64 a 84 b5 b 25 c 45 a 65 c 85 b6 c 26 d 46 b 66 b 86 a7 d 27 b 47 d 67 b 87 d8 a 28 d 48 b 68 c 88 c9 d 29 d 49 c 69 b 89 c10 b 30 d 50 d 70 c 90 c11 c 31 d 51 b 71 a 91 c12 c 32 c 52 d 72 d 92 d13 c 33 b 53 b 73 c 93 c14 d 34 b 54 d 74 c 94 a15 a 35 c 55 d 75 c 95 c16 a 36 d 56 d 76 b 96 b17 c 37 c 57 d 77 a 97 a18 d 38 b 58 c 78 d 98 b19 a 39 a 59 b 79 c 99 c20 d 40 b 60 c 80 b 100 a