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He Workshop Victoria 19 Sept Power Point Presentation

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    Introduction to HealthIntroduction to HealthEconomicsEconomics

    Gillian Currie, Craig Mitton,Gillian Currie, Craig Mitton,

    Stuart Peacock, Alan ShiellStuart Peacock, Alan Shiell

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    Session 1Session 1

    Techniques of Economic EvaluationTechniques of Economic Evaluation

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    The purpose of studying economics is notThe purpose of studying economics is not

    to acquire a set of ready-made answersto acquire a set of ready-made answers

    to economic questions, butto economic questions, but

    to learn how to avoid being deceived byto learn how to avoid being deceived by

    economists.economists.

    Joan Robinson, 1955Joan Robinson, 1955

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    The economic problemThe economic problem

    Resources are scarce, wants or demands are infiniteResources are scarce, wants or demands are infinite Individuals have to make choices or trade-offsIndividuals have to make choices or trade-offs

    Consumers have a budget constraintConsumers have a budget constraintbudget=disposable incomebudget=disposable income

    balanced against prices and amount of goods/services consumedbalanced against prices and amount of goods/services consumed

    Consumers have preferences - they know what they likeConsumers have preferences - they know what they likePreferences reflect well-being obtained through consumptionPreferences reflect well-being obtained through consumption

    Preferences are endowed & well behaved - axioms of choice &Preferences are endowed & well behaved - axioms of choice &utility theory (utility theory (von Neumann & Morgenstern 1947)von Neumann & Morgenstern 1947)

    All choices are risky expected utility theoryAll choices are risky expected utility theory

    Economics is the science of choiceEconomics is the science of choice

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    The health economic problemThe health economic problem

    Demand for health care is derived from demand for healthDemand for health care is derived from demand for health

    Demand for health care is infinite/or very large (with risingDemand for health care is infinite/or very large (with risingexpectations)expectations)

    Finite health sector resources are insufficient to meet allFinite health sector resources are insufficient to meet allthe health care needs of individuals & populations (withthe health care needs of individuals & populations (withrising costs of new technologies)rising costs of new technologies)

    Decision-makers need to determine:Decision-makers need to determine:

    whatwhat health care services to providehealth care services to provide forforwhomwhom to provide servicesto provide services howhow to provide servicesto provide services wherewhere services should be providedservices should be provided

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    Allocation of funds and facilities are nearly alwaysAllocation of funds and facilities are nearly always

    based on the opinion of consultants but, more andbased on the opinion of consultants but, more and

    more, requests for additional facilities will have tomore, requests for additional facilities will have to

    be based on detailed arguments with hardbe based on detailed arguments with hard

    evidence as to the gain to be expected from theevidence as to the gain to be expected from the

    patients angle and the cost. Few could possiblypatients angle and the cost. Few could possiblyobject to this.object to this.

    Cochrane AL. Effectiveness and Efficiency: randomCochrane AL. Effectiveness and Efficiency: random

    reflections on health services. Nuffield Provincialreflections on health services. Nuffield ProvincialHospitals Trust, London, 1972.Hospitals Trust, London, 1972.

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    If we are ever going to get the optimum resultsIf we are ever going to get the optimum resultsfrom our national expenditure on the NHS wefrom our national expenditure on the NHS we

    must finally be able to express the results in themust finally be able to express the results in theform of the benefit and the cost to theform of the benefit and the cost to the

    population of a particular type of activity, andpopulation of a particular type of activity, andthe increased benefit that would be obtained ifthe increased benefit that would be obtained if

    more money were made available.more money were made available.

    Cochrane AL. Effectiveness and Efficiency:Cochrane AL. Effectiveness and Efficiency:random reflections on health services. Nuffieldrandom reflections on health services. Nuffield

    Provincial Hospitals Trust, London, 1972.Provincial Hospitals Trust, London, 1972.

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    cost effectiveness rather than clinicalcost effectiveness rather than clinical

    excellence (efficiency over effectiveness)excellence (efficiency over effectiveness)

    linking costs and benefitslinking costs and benefits

    valuing human lifevaluing human life

    The pursuit should beThe pursuit should be

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    Please dont close the dialysis unit,Please dont close the dialysis unit,my wifes a nurse there. (UK,my wifes a nurse there. (UK,

    1994)1994)

    I hope your health is betterI hope your health is better

    than your economy. (US, 1996)than your economy. (US, 1996)

    Oh, so youre the finance person.Oh, so youre the finance person.(Canada, 2006)(Canada, 2006)

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    Economic PrinciplesEconomic Principles

    Opportunity costOpportunity cost When we choose to use resources to meet one need we give up theWhen we choose to use resources to meet one need we give up the

    "opportunity" to use those resources to meet some other need"opportunity" to use those resources to meet some other need

    The benefits associated with the best alternative use of thoseThe benefits associated with the best alternative use of those

    resources is theresources is the opportunity costopportunity cost

    The aim of economics is to ensure that we undertake activitiesThe aim of economics is to ensure that we undertake activitieswhere benefits outweigh opportunity costwhere benefits outweigh opportunity cost

    We do the most beneficial things with resources at our disposalWe do the most beneficial things with resources at our disposal

    The MarginThe Margin

    Marginal Cost = cost of one more unit of output/consumptionMarginal Cost = cost of one more unit of output/consumption Marginal Benefit = benefit from one more unit of output/consumptionMarginal Benefit = benefit from one more unit of output/consumption

    What does this mean?What does this mean?

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    Who likes beer?Who likes beer?

    Q. On a scale of 0 to 10Q. On a scale of 0 to 10

    howhow

    much does Harry like amuch does Harry like a

    pint?pint?

    10

    0

    Pint#1 Pint#2 Pint#3 Pint#4 Pint#5

    9

    10

    0

    8

    10

    0

    6.5

    10

    0

    4

    10

    0

    Harry likes beerHarry likes beer

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    Beer and CaviarBeer and Caviar Harry also likes CaviarHarry also likes Caviar

    But his allowance has beenBut his allowance has been

    curbed for staying out toocurbed for staying out too

    late he haslate he has 3030

    Beer costsBeer costs 5 a pint, caviar5 a pint, caviar

    costscosts 7.50 a serve7.50 a serve

    Harry thinks about his scoresHarry thinks about his scores

    for beer and caviarfor beer and caviar

    BeerBeer CaviarCaviar

    Ben-Ben-efitefit

    CostCost B/CB/C Ben-Ben-efitefit

    CostCost B/CB/C

    11 99 55 1.81.8 99 7.57.5 1.21.2

    22 88 55 1.61.6 66 7.57.5 0.80.8

    33 6.56.5 55 1.31.3 00 7.57.5 00

    44 44 55 0.80.8

    55 00 55 00

    Harry chooses 3 pints ofHarry chooses 3 pints of

    beer & 1 serve of caviar, hebeer & 1 serve of caviar, he

    is indifferent between the 4is indifferent between the 4thth pint or the 2pint or the 2ndnd serveserve

    If the ratio MB/MC is greaterIf the ratio MB/MC is greaterfor beer than for caviar thenfor beer than for caviar then

    he chooses beerhe chooses beer

    Total benefit is maximisedTotal benefit is maximised

    when MB/MC beer = MB/MCwhen MB/MC beer = MB/MC

    caviarcaviar

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    Allocating health careAllocating health care

    resourcesresources Allocating resources between health care programsAllocating resources between health care programs

    If MBIf MBAA/MC/MCAA > MB> MBBB/MC/MCBB transfer resources from program B to Atransfer resources from program B to A

    Getting more benefit per dollar spent at the margin in AGetting more benefit per dollar spent at the margin in A

    Implications of opportunity cost and marginal analysisImplications of opportunity cost and marginal analysis to do more of some things, we have to take resources fromto do more of some things, we have to take resources from

    elsewhere, by either doing the same things at less cost; orelsewhere, by either doing the same things at less cost; or

    taking resources from areas of (effective) caretaking resources from areas of (effective) care

    requires consideration of costs and benefits of health carerequires consideration of costs and benefits of health care

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    Efficiency ConceptsEfficiency Concepts

    Technical efficiencyTechnical efficiencyThe objective of an intervention is taken as givenThe objective of an intervention is taken as given

    Technical efficiency is about how best to achieveTechnical efficiency is about how best to achieve

    that objectivethat objective Allocative efficiencyAllocative efficiency All objectives have to fight with each other forAll objectives have to fight with each other for

    implementationimplementation

    It is aboutIt is about whetherwhether to do something rather thanto do something rather than howhowto do it (It can also be about how much to do)to do it (It can also be about how much to do)

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    What is EconomicWhat is Economic

    Evaluation?Evaluation?

    Economic evaluation is a set of scientific methods toEconomic evaluation is a set of scientific methods to

    assist decision-makers in making choices betweenassist decision-makers in making choices between

    alternative interventionsalternative interventions

    Concerned withConcerned with efficiencyefficiency not just effectivenessnot just effectiveness

    Based on principles of welfare economicsBased on principles of welfare economics Objective of the health system is to maximise the well-Objective of the health system is to maximise the well-

    being of the community from a fixed budgetbeing of the community from a fixed budget

    Opportunity costs choosing to provide one healthOpportunity costs choosing to provide one health

    program means forgoing benefits from other uses of thoseprogram means forgoing benefits from other uses of thoseresourcesresources

    Fair choices require a systematic comparison of costsFair choices require a systematic comparison of costs

    (resources) and consequences (outcomes or benefits) of(resources) and consequences (outcomes or benefits) of

    alternative health programsalternative health programs

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    Nature of EconomicNature of Economic

    EvaluationEvaluation

    TargetTarget

    patientpatient

    groupgroup

    SurvivalSurvival Quality of lifeQuality of life

    Program AProgram A

    Program BProgram B

    Impact on health statusImpact on health status

    Impact on health care costsImpact on health care costs

    Impact on health statusImpact on health status

    Impact on health care costsImpact on health care costs

    SurvivalSurvival Quality of lifeQuality of life

    HospitalisationsHospitalisations Drugs, procedures etc.Drugs, procedures etc.

    HospitalisationsHospitalisations Drugs, procedures etc.Drugs, procedures etc.

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    Types of EconomicTypes of Economic

    EvaluationEvaluation

    Cost-Effectiveness Analysis (CEA)Cost-Effectiveness Analysis (CEA) Benefits not explicitly valued - natural units used e.g. LifeBenefits not explicitly valued - natural units used e.g. Life

    Years Gained (LYG) or cases detectedYears Gained (LYG) or cases detected

    Difficult to compare across a wide range of programsDifficult to compare across a wide range of programs

    Cost-Utility Analysis (CUA)Cost-Utility Analysis (CUA) Benefits valued typically based on LYG weighted by anBenefits valued typically based on LYG weighted by an

    index of Quality of Life - Quality Adjusted Life Years (QALYs)index of Quality of Life - Quality Adjusted Life Years (QALYs)

    Cost-Benefit Analysis (CBA)Cost-Benefit Analysis (CBA) Benefits valued - based on monetary valuations of healthBenefits valued - based on monetary valuations of health

    improvements and expressed in dollarsimprovements and expressed in dollars

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    Study PerspectiveStudy Perspective

    Study question (& funding agency) determinesStudy question (& funding agency) determines

    perspectiveperspective

    Perspective determines costs/ consequences consideredPerspective determines costs/ consequences considered

    e.g. societal, government, provider, third party payere.g. societal, government, provider, third party payer

    Societal - widest possible range of costs/ consequencesSocietal - widest possible range of costs/ consequences

    Provider - e.g. exclude time and transportation costsProvider - e.g. exclude time and transportation costs

    Run societal perspective alongside other studyRun societal perspective alongside other study

    perspectivesperspectives

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    CostsCosts

    Identify, measure and value all resources withIdentify, measure and value all resources with

    +ve opportunity costs+ve opportunity costs

    Direct health care costs (e.g. costs ofDirect health care costs (e.g. costs of

    treatment)treatment) Direct personal costs (e.g. transportation)Direct personal costs (e.g. transportation)

    Direct non-health costs (e.g. legal system)Direct non-health costs (e.g. legal system)

    Indirect costs (e.g. productivity losses)Indirect costs (e.g. productivity losses) Valuation of opportunity costs - marketValuation of opportunity costs - market

    prices/shadow pricesprices/shadow prices

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    BenefitsBenefits

    Cost-Effectiveness AnalysisCost-Effectiveness Analysis Measure benefits in natural units e.g. LYGMeasure benefits in natural units e.g. LYG

    Addresses technical efficiency, difficult to compare across programsAddresses technical efficiency, difficult to compare across programs

    Cost-Utility AnalysisCost-Utility Analysis

    Measure benefits in terms of QALYsMeasure benefits in terms of QALYs

    Addresses technical efficiency, easier to compare across programsAddresses technical efficiency, easier to compare across programs

    Cannot be used to determine optimal size of health programsCannot be used to determine optimal size of health programs

    Cost-Benefit AnalysisCost-Benefit Analysis

    Measure benefits in terms of dollar valuationsMeasure benefits in terms of dollar valuations

    Addresses allocative efficiency, easier to compare across programsAddresses allocative efficiency, easier to compare across programs Can be used to compare health and non-health programsCan be used to compare health and non-health programs

    Qualit Adjusted Life YearsQuality Adjusted Life Years

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    0.0

    1.0

    0.4

    0.2

    0.6

    0.8

    Initial

    Final

    Quality Adjusted Life YearsQuality Adjusted Life Years

    (QALYs)(QALYs)Full

    Health

    Dead

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    DialysisDialysis

    TransplanTransplan

    tt

    Life Years Gained= 6Life Years Gained= 6

    QALYs Gained = 8.8QALYs Gained = 8.8

    00 1414 2020

    Life YearsLife Years

    0.80.8

    0.60.6

    QualityofLif

    e

    QualityofLif

    e

    Quality Adjusted Life YearsQuality Adjusted Life Years

    (QALYs)(QALYs)

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    Incremental Cost-EffectivenessIncremental Cost-Effectiveness

    Ratio (ICER)Ratio (ICER)

    (Cost(Costnewnew Cost Costoldold ))

    (Effectiveness(Effectivenessnewnew Effectiveness Effectivenessoldold ))

    IncrementalIncremental

    resources requiredresources requiredby theby the

    interventionintervention

    Incremental healthIncremental health

    effects gained byeffects gained byusing theusing the

    interventionintervention

    ICER =ICER = C /C / EE

    = ICER= ICER

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    A simple decision ruleA simple decision rule

    ICER for new program $50,000/QALYICER for new program $50,000/QALY

    Decision:Decision: adopt new programadopt new program

    ICER for new program> $50,000/QALYICER for new program> $50,000/QALY

    Decision:Decision: do not adopt new programdo not adopt new program

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    $20,000/QALY$20,000/QALY

    $100,000/QALY$100,000/QALY

    CC

    BB

    DD

    EE

    AA

    Decrease in QALYsDecrease in QALYs Increase in QALYsIncrease in QALYs

    More CostlyMore Costly

    Less CostlyLess Costly

    Grades of recommendation for new technologiesGrades of recommendation for new technologies

    The Cost-Effectiveness Acceptability PlaneThe Cost-Effectiveness Acceptability Plane

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    $20,000/QALY$20,000/QALY

    $100,000/QALY$100,000/QALY

    CC

    BB

    DD

    EE

    AA

    Decrease in QALYsDecrease in QALYs Increase in QALYsIncrease in QALYs

    More CostlyMore Costly

    Less CostlyLess Costly

    New technology is as/more effective & less costly: incremental cost/QALY

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    $20,000/QALY$20,000/QALY

    $100,000/QALY$100,000/QALY

    CC

    BB

    DD

    EE

    AA

    Decrease in QALYsDecrease in QALYs Increase in QALYsIncrease in QALYs

    More CostlyMore Costly

    Less CostlyLess Costly

    New technology more effective, incremental cost/QALY$20,000New technology more effective, incremental cost/QALY$20,000

    B. Strong evidence for adoptionB. Strong evidence for adoption

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    $100,000/QALY$100,000/QALY

    CC

    BB

    DD

    EE

    AA

    New technology more effective, incremental cost/QALY $100,000New technology more effective, incremental cost/QALY $100,000

    C. Moderate evidence for adoptionC. Moderate evidence for adoption

    Increase in QALYsIncrease in QALYs

    More CostlyMore Costly

    Less CostlyLess Costly

    Decrease in QALYsDecrease in QALYs

    $20,000/QALY$20,000/QALY

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    $20,000/QALY$20,000/QALY

    $100,000/QALY$100,000/QALY

    CC

    BB

    DD

    EE

    AA

    Decrease in QALYsDecrease in QALYs Increase in QALYsIncrease in QALYs

    More CostlyMore Costly

    Less CostlyLess Costly

    New technology more effective, incremental cost/QALY > $100,000New technology more effective, incremental cost/QALY > $100,000

    D. Weak evidence for adoptionD. Weak evidence for adoption

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    $20,000/QALY$20,000/QALY

    $100,000/QALY$100,000/QALY

    CC

    BB

    DD

    EE

    AA

    Decrease in QALYsDecrease in QALYs Increase in QALYsIncrease in QALYs

    More CostlyMore Costly

    Less CostlyLess Costly

    New technology is less effective, or as effective, and more costlyNew technology is less effective, or as effective, and more costly

    E. Compelling evidence for rejectionE. Compelling evidence for rejection

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    Why is Economic EvaluationWhy is Economic Evaluation

    important?important?

    SafetySafety Cost-Cost-

    EffectivenessEffectiveness

    QualityQualityEfficacyEfficacy

    The Fourth HurdleThe Fourth Hurdle

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    Economic Evaluation forEconomic Evaluation for

    reimbursement decisionsreimbursement decisions

    Many jurisdictions now require economic evaluation forMany jurisdictions now require economic evaluation for

    reimbursement decisions (primarily for drugs)reimbursement decisions (primarily for drugs)

    Accompanied by guidelines for pharmaceutical companiesAccompanied by guidelines for pharmaceutical companies

    Pricing decisions may or may not be linked with reimbursement decisionsPricing decisions may or may not be linked with reimbursement decisions

    Australia: Pharmaceutical Benefits Advisory Committee (PBAC)Australia: Pharmaceutical Benefits Advisory Committee (PBAC) England and Wales: National Institute for Health and ClinicalEngland and Wales: National Institute for Health and Clinical

    Excellence (NICE)Excellence (NICE)

    Based on Acceptable Incremental Cost-Effectiveness RatiosBased on Acceptable Incremental Cost-Effectiveness Ratios

    (ICERs)(ICERs)

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    Economic Evaluation in EuropeEconomic Evaluation in EuropeNorway:

    Pharmacoeconomic data

    required for reimbursement;

    official guidelines inoperation.

    Finland:

    Pharmacoeconomic evidence mandatory for evaluating new

    therapies for reimbursement and may also be requested for

    existing therapies.

    Sweden:

    Cost-effectiveness data required

    for reimbursement.

    Denmark:

    Cost-effectiveness data may be requested

    for reimbursement decisions.

    Britain:

    NICE evaluates the cost

    effectiveness of medicines.Guidelines updated April 2004.

    Germany:

    Guidelines prepared.

    Institute for Quality and

    Efficiency in the Health

    Service established in

    2004.

    France:

    Not a formal requirement but

    increasingly used in

    reimbursement decisions.

    Guidelines prepared.

    Spain:

    Health technologyassessment at a

    regional level.

    Portugal:

    Cost-effectiveness data

    incorporated

    into reimbursement decisions.

    Italy:

    Cost-effectiveness considered in

    pricing and reimbursement

    decisions. Greece: Guidelines for pharmacoeconomic studies

    prepared; cost-effectiveness data may be requested.

    Belgium:Formal requirement for economic

    evaluation.

    Netherlands:

    Pharmacoeconomic evidence explicitly

    required for reimbursement of new

    products.

    Ireland: Guidelines for

    pharmacoeconomic

    studies prepared; cost-

    effectiveness data may

    be requested.

    Source: National Centre for Pharmacoeconomics, Ireland

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    How high do you have toHow high do you have to

    jump?jump?

    $20,000/$20,000/

    QALYQALY

    $50,000/$50,000/

    QALYQALY

    $60,000/$60,000/

    QALYQALY

    $100,000/$100,000/

    QALYQALY

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    ICERs and Cancer ControlICERs and Cancer Control

    Source: Rawlings. 2007

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    National cost-effectiveness guidance has only madeNational cost-effectiveness guidance has only made

    a limited or moderate impact on real-world decisionsa limited or moderate impact on real-world decisions Demonstration of clinically-important benefit is stillDemonstration of clinically-important benefit is still

    paramountparamount

    Economic analysis is more important when there isEconomic analysis is more important when there is

    substantial budgetary impactsubstantial budgetary impact

    Lack of available and transferable economic evidence is aLack of available and transferable economic evidence is a

    challenge, but it is not the most important challengechallenge, but it is not the most important challenge

    There are broader contextual factors (systems,There are broader contextual factors (systems,

    organizational and ethical considerations) that influenceorganizational and ethical considerations) that influence

    priority setting decisionspriority setting decisions

    What lessons have we learned?What lessons have we learned?

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    Local health care organizations, clinicians and managersLocal health care organizations, clinicians and managers

    bear the opportunity cost of priority setting decisionsbear the opportunity cost of priority setting decisions

    Priority setting decisions are typically made at the local levelPriority setting decisions are typically made at the local level

    National cost-effectiveness guidance does not consider the limitedNational cost-effectiveness guidance does not consider the limited

    budgets of local decision-makersbudgets of local decision-makers

    Cost-effectiveness thresholds are set arbitrarily byCost-effectiveness thresholds are set arbitrarily bynational bodiesnational bodies

    Economic evidence is context freeEconomic evidence is context free

    Most economists are unconcerned with implementation issuesMost economists are unconcerned with implementation issues

    Local decision-making processes are assumed to be a black box inLocal decision-making processes are assumed to be a black box in

    reality they are deliberative processesreality they are deliberative processes

    What lessons have we learned?What lessons have we learned?

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    Who has the ethical authority?Who has the ethical authority?

    If economists could manage to getIf economists could manage to get

    themselves thought of as humble,themselves thought of as humble,

    competent people, on a level withcompetent people, on a level with

    dentists, that would be splendid!dentists, that would be splendid!

    John Maynard Keynes, 1931John Maynard Keynes, 1931

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    Session 2Session 2

    Measuring costs and benefitsMeasuring costs and benefits

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    OverviewOverview

    An example to highlight basic principlesAn example to highlight basic principles

    CostingCosting

    Some definitionsSome definitions

    Some rulesSome rules

    Discounting and Sensitivity AnalysisDiscounting and Sensitivity Analysis

    BenefitsBenefits

    What are the benefits of health interventions?What are the benefits of health interventions?

    Measurement and valuatio of benefitsMeasurement and valuatio of benefits

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    Thinking at the margin: screeningThinking at the margin: screening

    for cancer of the colonfor cancer of the colon

    Stool is tested for the presence of occult bloodStool is tested for the presence of occult blood

    Proposal was for six sequential testsProposal was for six sequential tests

    Neuhauser and Lewicki analysed the proposal, onNeuhauser and Lewicki analysed the proposal, onthe basis of:the basis of: a population of 10,000 of whom 72 have colonica population of 10,000 of whom 72 have colonic

    cancercancer

    each test detects 91.67 per cent of caseseach test detects 91.67 per cent of cases

    undetected by the previous test.undetected by the previous test.

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    Screening for cancer of theScreening for cancer of the

    coloncolon

    Cases detected and costs of screening with sixCases detected and costs of screening with sixsequential testssequential tests

    No. of testsNo. of tests No. of casesNo. of cases Total costs($)Total costs($) Av. Cost($)Av. Cost($)

    11 65.946965.9469 77,51177,511 11751175

    22 71.442471.4424 107,690107,690 15071507

    33 71.900371.9003 130,199130,199 18111811

    44 71.938571.9385 148,116148,116 20592059

    55 71.941771.9417 163,141163,141 2268226866 71.942071.9420 176,331176,331 24512451

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    Marginal analysis of screeningMarginal analysis of screening

    for cancer of the colonfor cancer of the colon

    Incremental cases detected and incremental (and marginal) costs ofIncremental cases detected and incremental (and marginal) costs of

    screening with six sequential testsscreening with six sequential tests

    No. of testsNo. of tests IncrementalIncremental IncrementalIncremental MarginalMarginal

    cases detectedcases detected costs ($)costs ($) costs ($)costs ($)

    11 65.946965.9469 77,51177,511 11751175

    22 5.49565.4956 30,17930,179 54945494

    33 0.45800.4580 22,50922,509 49,15049,150

    44 0.03820.0382 17,91717,917 469,534469,534

    55 0.00320.0032 15,02415,024 4,724,6954,724,695

    66 0.00030.0003 13,19013,190 47,107,21447,107,214

    li i f i

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    Implications of opportunityImplications of opportunity

    cost and marginal analysiscost and marginal analysis

    to do more of some things, we have to taketo do more of some things, we have to takeresources from elsewhere:resources from elsewhere: by doing the same things at less cost (technical efficiency)by doing the same things at less cost (technical efficiency) by taking resources from an effective area of care because a newby taking resources from an effective area of care because a new

    proposal is more effective per $ spent (allocative efficiency)proposal is more effective per $ spent (allocative efficiency)

    measure costs and benefits of health caremeasure costs and benefits of health care

    often aboutoften about how muchhow much rather thanrather than whetherwhether

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    AlwaysAlways

    ..identify..identify

    ..measure..measure

    ..value..value

    Have we included everything that is relevant?Have we included everything that is relevant?

    Have we counted it?Have we counted it?

    Have we converted it to a common currency?Have we converted it to a common currency?

    Costs and benefits: threeCosts and benefits: three

    important stepsimportant steps

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    Total costTotal cost = sum of all the costs of producing a particular quantity of= sum of all the costs of producing a particular quantity of

    outputoutput

    Average costAverage cost= total cost/quantity e.g. cost per patient, cost= total cost/quantity e.g. cost per patient, costper diemper diem

    Marginal costMarginal cost= the= the extraextra cost of producing onecost of producing one extraextra unit of outputunit of output

    Fixed costsFixed costs = costs which do not vary with the quantity of output in the= costs which do not vary with the quantity of output in the

    short run (about 1 year) e.g. rent, equipment lease payments, someshort run (about 1 year) e.g. rent, equipment lease payments, somewages and salaries.wages and salaries.

    Variable costsVariable costs = costs which vary with the level of output, e.g. food,= costs which vary with the level of output, e.g. food,

    medical/surgical suppliesmedical/surgical supplies

    Definitions of costDefinitions of cost

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    Hospital inpatient day

    Av. cost = 1,000

    Day in non-hospital setting

    Av. cost = 400

    Allocated

    overhead (fixed)cost per day

    = 700

    Variable /

    marginal costs

    = 300

    Set up = 400

    Marginal costs: an exampleMarginal costs: an example

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    Marginal costs: an example

    Hospital inpatient day

    Av. cost = 1,000

    Day in non-hospital setting

    Av. cost = 400

    Allocated

    overhead (fixed)cost per day

    = 700

    Variable /

    marginal costs

    = 300

    Set up = 400

    Extra cost = 100

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    Get the question right!Get the question right!

    What is the cost of a delivery in a ScottishWhat is the cost of a delivery in a Scottishmaternity unit?maternity unit?

    Unit cost = 540Unit cost = 540

    Cost if assume beds have to be increasedCost if assume beds have to be increased

    = 510= 510 Cost if bed numbers remain fixed (i.e. there is spare capacity)Cost if bed numbers remain fixed (i.e. there is spare capacity)

    = 210= 210

    So,So, marginal costsmarginal costs are importantare important

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    It is uses of resources which have opportunityIt is uses of resources which have opportunity

    costs. Therefore, in evaluating an intervention,costs. Therefore, in evaluating an intervention,

    we want towe want to identifyidentify,, measuremeasure andand valuevalueresource use.resource use.

    Some things usually thought to be costs areSome things usually thought to be costs are

    not so in an economic evaluation.not so in an economic evaluation.

    Rules for costingRules for costing

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    Rules for costingRules for costing

    We are interested inWe are interested in resourceresource useuse

    Main items of cost are:Main items of cost are:

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    Rules for costingRules for costing

    We are interested inWe are interested in resourceresource useuse

    Main items of cost are:Main items of cost are: capital (buildings/equipment)capital (buildings/equipment)

    labourlabour

    consumablesconsumables non-patient related costsnon-patient related costs

    costs falling on other sectorscosts falling on other sectors

    costs incurred by patients/familiescosts incurred by patients/families

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    Eg. - Costing an interventionEg. - Costing an intervention

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    Indirect costs:Indirect costs: Time lost from work (production effects)Time lost from work (production effects)

    Production effects arise from working in the labour force andProduction effects arise from working in the labour force and

    houseworkhousework

    Indirect costs arise because health care may result in lostIndirect costs arise because health care may result in lost

    productionproductionValue of indirect cost is the value of the lost productionValue of indirect cost is the value of the lost production

    Is this an input to treatment or an output? (Will return)Is this an input to treatment or an output? (Will return)

    Take a societal perspective.Take a societal perspective.

    Indirect costs: a controversyIndirect costs: a controversy

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    Double counting: including the same cost more than onceDouble counting: including the same cost more than once

    e.g. including time costs and fees and then adding theme.g. including time costs and fees and then adding themtogether (often the fee reflects time spent on activities)together (often the fee reflects time spent on activities)

    e.g. detailed costing of staff time in an operatinge.g. detailed costing of staff time in an operating

    theatre and then adding the hourly cost of theatre timetheatre and then adding the hourly cost of theatre timewhich may already include costs for staff time as well aswhich may already include costs for staff time as well asamounts for drugs, supplies, equipment etc.amounts for drugs, supplies, equipment etc.

    Double countingDouble counting

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    Evaluate the evaluationEvaluate the evaluation

    Whose perspective?Whose perspective?

    Where do we draw the line?Where do we draw the line?

    Use common senseUse common sense

    The extent of the analysisThe extent of the analysis

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    Use naturally occurring unitsUse naturally occurring units

    e.g. staff costs measured in units of timee.g. staff costs measured in units of time

    drugs measured in amounts such as gramsdrugs measured in amounts such as grams

    MeasurementMeasurement

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    Costing non-market labourCosting non-market labour

    No market values for housework and voluntaryNo market values for housework and voluntary

    workwork

    Where possible, impute values from anWhere possible, impute values from ananalogous marketanalogous market

    P ti t b dPatient based ersus diper diem

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    When comparing groups of patients, ideal is to measure each patientsWhen comparing groups of patients, ideal is to measure each patients

    consumption of health care and other resources - patient basedconsumption of health care and other resources - patient based

    costingcosting

    Alternative is to calculate aAlternative is to calculate aper diemper diem cost and multiply by period ofcost and multiply by period of

    consumptionconsumption

    Problem withProblem withper diemper diem costing?costing?

    Too generalToo general

    Possible half-way-house solution -Possible half-way-house solution -per diemper diem costing at the ward levelcosting at the ward level

    Patient-based versusPatient-based versusper diemper diemcostingcosting

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    Can be a challengeCan be a challenge

    Do overheads represent a marginalDo overheads represent a marginal

    opportunity cost? (Remember fixedopportunity cost? (Remember fixedversus variable costs.)versus variable costs.)

    Depends upon their magnitudeDepends upon their magnitude

    Allocation of overheadsAllocation of overheads

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    Capital costs tend to occur at a single point in timeCapital costs tend to occur at a single point in time

    However, capital assets are used over time and can beHowever, capital assets are used over time and can be

    sold at any timesold at any time

    Opportunity cost of capital is spread over timeOpportunity cost of capital is spread over time

    Calculate an annual equivalent cost (like a mortgage)Calculate an annual equivalent cost (like a mortgage)

    Costing capitalCosting capital

    Unthinking acceptance ofUnthinking acceptance of

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    Be careful!!Be careful!!

    Unthinking acceptance ofUnthinking acceptance of

    market valuesmarket values

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    Costing study alongside clinicalCosting study alongside clinical

    trial: exampletrial: example

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    Croup studyCroup study

    Trial was of a single dose of oral dexamethasone forTrial was of a single dose of oral dexamethasone forchildren with mild croupchildren with mild croup

    Mild was defined according to a validated croup scoringMild was defined according to a validated croup scoringsystemsystem

    Trial examined differences in:Trial examined differences in:

    Return to medical care provider for croup within 7 days ofReturn to medical care provider for croup within 7 days oftxtx

    Presence of ongoing croup symptoms on days 1,2, 3 postPresence of ongoing croup symptoms on days 1,2, 3 posttxtx

    CostsCosts Hours of sleep lost by childHours of sleep lost by child

    Parental stressParental stress

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    The trial showedThe trial showed

    The group treated with dexamethasone had:The group treated with dexamethasone had: Fewer patients who returned to medical care withinFewer patients who returned to medical care within

    seven daysseven days

    Quicker resolution of croup symptomsQuicker resolution of croup symptoms

    Less lost sleepLess lost sleep Less stress on the part of parentsLess stress on the part of parents

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    What cost data would you collect?What cost data would you collect?

    How would you collect dataHow would you collect data

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    How would you collect dataHow would you collect data

    on:on:

    Capital/equipment?Capital/equipment?

    Staff?Staff?

    Consumables?Consumables?

    Other costs?Other costs?

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    The cost study is trial basedThe cost study is trial based

    Therefore, we need to decide:Therefore, we need to decide:

    What data to collect outside of the trialWhat data to collect outside of the trial

    What data to collect within the trialWhat data to collect within the trial

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    Data collected outside theData collected outside the

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    Data collected outside theData collected outside the

    trialtrial

    Costs of physician visitsCosts of physician visits

    Costs of emergency and inpatient visitsCosts of emergency and inpatient visits

    Costs of (some) patient costsCosts of (some) patient costs

    Average daily wageAverage daily wage

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    FindingsFindings

    Total average societal costs per case:Total average societal costs per case: $93 for placebo vs $72 for treatment$93 for placebo vs $72 for treatment

    Payer costsPayer costs $25 vs $18$25 vs $18

    Mainly driven by RHA costsMainly driven by RHA costs

    Family costsFamily costs $68 vs $54$68 vs $54

    Mainly lost days of workMainly lost days of work

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    Sensitivity analysisSensitivity analysis

    To test SENSITIVITY of the results to variationsTo test SENSITIVITY of the results to variationsin assumptions or data about which you arein assumptions or data about which you areunsureunsure

    In the croup study, sensitivity analysis wasIn the croup study, sensitivity analysis wasconducted around the productivity costsconducted around the productivity costs

    Most of the overall cost difference was driven by lostMost of the overall cost difference was driven by lostproductivityproductivity

    Excluding productivity costs, overall costs still lowerExcluding productivity costs, overall costs still lower

    with treatment $38 vs $31with treatment $38 vs $31

    Combining costs andCombining costs and

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    Combining costs andCombining costs and

    outcomesoutcomes

    With treatment, primary clinical outcomesWith treatment, primary clinical outcomes

    were improved, as were secondary clinicalwere improved, as were secondary clinical

    outcomesoutcomes

    With treatment, costs were lower for familiesWith treatment, costs were lower for families

    and payers.and payers.

    Conclusion: the treatment is dominant, andConclusion: the treatment is dominant, and

    should be implemented.should be implemented.

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    Sensitivity analysisSensitivity analysis

    DiscountingDiscounting

    Important refinementsImportant refinements

    Candidates for sensitivity analysis in costingCandidates for sensitivity analysis in costing

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    Candidates for sensitivity analysis in costingCandidates for sensitivity analysis in costing

    exercise:exercise:

    production effectsproduction effects

    estimates of survival/quality of lifeestimates of survival/quality of life

    excluded itemsexcluded items

    imputed valuesimputed values lengths of life of capital itemslengths of life of capital items

    discount ratediscount rate

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    Interested inInterested in realreal resource useresource use

    Adjust costs to eliminate effects of inflationAdjust costs to eliminate effects of inflation

    Assuming 5% inflation:Assuming 5% inflation:

    $100 last year$100 last year $100 now$100 now

    $100 last year = $105 at todays prices$100 last year = $105 at todays prices

    Counting costs in a base yearCounting costs in a base year

    Why do we discount theWhy do we discount the

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    Costs and benefits arise at different points in time (e.g. prevention)Costs and benefits arise at different points in time (e.g. prevention)

    We want to look at costs and benefits from the perspective of theWe want to look at costs and benefits from the perspective of thepresent daypresent day

    Discounting is simply the expression of opportunity cost over time, i.e.Discounting is simply the expression of opportunity cost over time, i.e. tying up resources nowtying up resources now

    not having benefits nownot having benefits now

    The same cost arising in the future impinges on us less than if it aroseThe same cost arising in the future impinges on us less than if it arosenownow

    The same benefit arising in the future is not seen as being as valuableThe same benefit arising in the future is not seen as being as valuableas the same benefit arising nowas the same benefit arising now

    So, we discount these future costs and benefitsSo, we discount these future costs and benefits

    This is not accepted by everybodyThis is not accepted by everybody

    Why do we discount theWhy do we discount the

    future?future?

    i i

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    Question: Should costs (and benefits) occurringQuestion: Should costs (and benefits) occurring

    at different points in time, be given equalat different points in time, be given equal

    weighting?weighting?

    If I offered to give you 1000 today ORIf I offered to give you 1000 today OR

    1000 in 5 years which would you choose?1000 in 5 years which would you choose?

    Would you rather pay me 1000 today ORWould you rather pay me 1000 today OR

    1000 in 5 years?1000 in 5 years?

    DiscountingDiscounting

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    We have positive time preference because:We have positive time preference because:

    myopia or impatiencemyopia or impatience

    diminishing marginal utility of wealthdiminishing marginal utility of wealth

    diminishing marginal utility of healthdiminishing marginal utility of health

    the future is uncertainthe future is uncertain

    But, how do we calculate discounted costs and benefitsBut, how do we calculate discounted costs and benefits

    and at what rate should we discount?and at what rate should we discount?

    i iDi i

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    Present Value:Present Value:

    PV=present valuePV=present value

    VVnn=Value in year n=Value in year n

    r=discount rater=discount rate

    n=number of years aheadn=number of years ahead

    n

    n

    r

    VPV

    )1( +

    =

    DiscountingDiscounting

    i i lDi ti l

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    Which would you rather have: 1000Which would you rather have: 1000

    today or 1000 in five years time?today or 1000 in five years time?

    What is 1000 in five years worthWhat is 1000 in five years worth todaytoday??

    PV= 1000 (1/1.05)PV= 1000 (1/1.05)55 = 783.50= 783.50

    1000 in five years is worth less than1000 in five years is worth less than

    1000 today1000 today

    Discounting exampleDiscounting example

    Ch i f diCh i f di t t

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    Consistent with empirical economic studiesConsistent with empirical economic studies

    Include government recommended ratesInclude government recommended rates

    Consistent with other published economicConsistent with other published economic

    evaluations.evaluations.

    Choice of discount rateChoice of discount rate

    Main arguments againstMain arguments against

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    OK to discount money, but not healthOK to discount money, but not health

    Inter-generational equityInter-generational equity

    Main arguments againstMain arguments against

    discountingdiscounting

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    Measurement and valuation of benefitsMeasurement and valuation of benefits

    B fitB fit

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    BenefitsBenefits

    What do we mean by benefit?What do we mean by benefit?

    How do we describe Health-Related Quality of LifeHow do we describe Health-Related Quality of Life

    benefits?benefits?

    How do we obtain valuations for health and non-healthHow do we obtain valuations for health and non-health

    benefits?benefits?

    What do we mean byWhat do we mean by

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    What do we mean byWhat do we mean by

    benefit?benefit?

    Cases detected, cases treated, lives/life years saved (CEA)Cases detected, cases treated, lives/life years saved (CEA)

    Combination of quality and length of life e.g. QALYs (CUA)Combination of quality and length of life e.g. QALYs (CUA)

    Utility based Health State valuationsUtility based Health State valuations

    More general measures of well-being (CBA)More general measures of well-being (CBA)

    Valuing health and non-health benefits, e.g. reducingValuing health and non-health benefits, e.g. reducing

    inequalities, raising empowerment, improving accessinequalities, raising empowerment, improving access

    Why do we need valuations of benefits?Why do we need valuations of benefits?

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    Why do we need valuations of benefits?Why do we need valuations of benefits?

    Historical focus has been on mortality-based measuresHistorical focus has been on mortality-based measuresof benefitsof benefits

    But measures should take into account morbidity andBut measures should take into account morbidity and

    mortality benefits of programsmortality benefits of programs

    Preferences for Health States are used to estimatePreferences for Health States are used to estimatemorbidity or Health-Related Quality of Life (HRQoL)morbidity or Health-Related Quality of Life (HRQoL)

    componentcomponent

    Data on mortality and morbidity/HRQoL are combinedData on mortality and morbidity/HRQoL are combined

    into a single index (typically QALYs)into a single index (typically QALYs)

    Why do we need valuations ofWhy do we need valuations of

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    Why do we need valuations ofWhy do we need valuations of

    benefits?benefits?

    QALYs allow comparisons acrossQALYs allow comparisons across different programsdifferent programs

    disease groupsdisease groups

    sick versus wellsick versus well

    young versus oldyoung versus old

    Can detect unexpected side effectsCan detect unexpected side effects

    Preferences for health and non-health benefitsPreferences for health and non-health benefits

    permit broader comparisons across health programspermit broader comparisons across health programs

    permit comparisons with non-health programspermit comparisons with non-health programs

    Methods for valuingMethods for valuing

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    gg

    benefitsbenefits Valuing health benefits (HRQoL)Valuing health benefits (HRQoL)

    Visual Analogue Scale (VAS)Visual Analogue Scale (VAS)

    Time Trade-Off (TTO)Time Trade-Off (TTO)

    Standard Gamble (SG)Standard Gamble (SG)

    Valuing health and non-health benefitsValuing health and non-health benefits Willingness To Pay (WTP)Willingness To Pay (WTP)

    Discrete Choice Experiments (DCEs)Discrete Choice Experiments (DCEs)

    Steps in constructing anSteps in constructing an

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    Steps in constructing anSteps in constructing an

    HRQoL Utility InstrumentHRQoL Utility Instrument

    Decompose HealthDecompose Health Impairment, Disability, HandicapImpairment, Disability, Handicap

    Construct a coherent Descriptive SystemConstruct a coherent Descriptive System set of questions / itemsset of questions / items

    Attach utility weights to itemsAttach utility weights to items Elicit preference values for Health States included in theElicit preference values for Health States included in the

    descriptive systemdescriptive system

    VAS, TTO, SGVAS, TTO, SG

    Combine items (using a utility model)Combine items (using a utility model) additive, multiplicativeadditive, multiplicative

    Main HRQoL UtilityMain HRQoL Utility

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    Q yQ y

    InstrumentsInstruments EQ-5D (Euroqol)EQ-5D (Euroqol)

    SF-6D (based on SF-36)SF-6D (based on SF-36)

    HUI-III (Health Utilities Index Mark III)HUI-III (Health Utilities Index Mark III)

    AQoL (Assessment of Quality of Life)AQoL (Assessment of Quality of Life)

    QWB (Quality of Well-Being)QWB (Quality of Well-Being)

    Rosser-Kind IndexRosser-Kind Index

    EQ 5D Descripti e S stemEQ 5D Descriptive System

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    EQ-5D Descriptive SystemEQ-5D Descriptive System

    MobilityMobility

    Self-careSelf-care

    Usual activitiesUsual activities

    Pain/discomfortPain/discomfort

    Anxiety/depressionAnxiety/depression

    243 states, 3 levels per attribute243 states, 3 levels per attribute

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    HUI III Descriptive SystemHUI III Descriptive System

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    HUI-III Descriptive SystemHUI-III Descriptive System

    VisionVision

    HearingHearing

    SpeechSpeech

    AmbulationAmbulation

    DexterityDexterity CognitionCognition

    Pain and discomfortPain and discomfort

    EmotionEmotion

    972,000 states, 5-6 levels per attribute972,000 states, 5-6 levels per attribute

    Valuing health benefitsValuing health benefits

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    gg

    (HRQoL)(HRQoL) Visual Analogue Scale (VAS)Visual Analogue Scale (VAS)

    Time Trade-Off (TTO)Time Trade-Off (TTO)

    Standard Gamble (SG)Standard Gamble (SG)

    Visual Analogue Scale (VAS)Visual Analogue Scale (VAS)

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    Visual Analogue Scale (VAS)Visual Analogue Scale (VAS)

    1.00

    0.00

    0.50

    0.7

    5

    0.25

    Dead

    Full Health

    Poor Health

    Visual Analogue Scale (VAS)Visual Analogue Scale (VAS)

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    Visual Analogue Scale (VAS)Visual Analogue Scale (VAS)

    1.00

    0.00

    0.50

    0.7

    5

    0.25

    Dead

    Full Health

    Place the HealthState forChildhoodLeukaemia onthe scale

    Visual Analogue Scale (VAS)Visual Analogue Scale (VAS)

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    Visual Analogue Scale (VAS)Visual Analogue Scale (VAS)

    Easy to administer and achieve high response ratesEasy to administer and achieve high response rates

    No difficult choicesNo difficult choices

    Respondents tend to shy away from the end-points ofRespondents tend to shy away from the end-points of

    the scalethe scale

    ButBut

    Time Trade Off (TTO)Time Trade Off (TTO)

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    Time Trade-Off (TTO)Time Trade-Off (TTO)

    Choice between two certain outcomesChoice between two certain outcomes

    Years of life traded for quality of lifeYears of life traded for quality of life

    Years of healthy life you would give up toYears of healthy life you would give up to

    avoid living in a state of poor healthavoid living in a state of poor health

    Time Trade Off (TTO)Time Trade Off (TTO)

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    Time Trade-Off (TTO)Time Trade-Off (TTO)ExampleExample

    You have arthritis (unable to do household and personal careYou have arthritis (unable to do household and personal care

    tasks, difficulty walking)tasks, difficulty walking)

    Choose between living with arthritis for the next 10 yearsChoose between living with arthritis for the next 10 years

    (followed by immediate death) or living in full health for a shorter(followed by immediate death) or living in full health for a shorter

    length of time (followed by immediate death)length of time (followed by immediate death)

    Would you choose 1 year of full health (followed by death) or 10Would you choose 1 year of full health (followed by death) or 10years with arthritis (followed by death)?years with arthritis (followed by death)?

    Would you choose 9 years of full health (followed by death) or 10Would you choose 9 years of full health (followed by death) or 10

    years with arthritis (followed by death)?years with arthritis (followed by death)?

    Flip-flop until preference value is foundFlip-flop until preference value is found

    Time Trade-Off (TTO)

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    Time Trade Off (TTO)Time Trade Off (TTO)

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    Time Trade-Off (TTO)Time Trade-Off (TTO)

    Utility of Health State A is T/10Utility of Health State A is T/10 T is the number of years in full healthT is the number of years in full health

    10 is the number of years in Health State A10 is the number of years in Health State A

    If years in full health selected was 6If years in full health selected was 6

    Utility (HSUtility (HSAA)= 6/10 = 0.60)= 6/10 = 0.60

    The better Health State A is, the less the yearsThe better Health State A is, the less the years

    of healthy life you would give upof healthy life you would give up

    Standard Gamble (SG)Standard Gamble (SG)

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    Standard Gamble (SG)Standard Gamble (SG)

    Classical method of assessing preferencesClassical method of assessing preferences

    Choose between certain outcome and a gambleChoose between certain outcome and a gamble

    Conforms to axioms of expected utility theoryConforms to axioms of expected utility theory

    Incorporates uncertainty, therefore better reflects realIncorporates uncertainty, therefore better reflects real

    treatment decisionstreatment decisions

    If respondent is risk neutral then utilities from SG shouldIf respondent is risk neutral then utilities from SG should

    be the same as from TTObe the same as from TTO

    Standard Gamble (SG)Standard Gamble (SG)

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    Standard Gamble (SG)Standard Gamble (SG)

    You have end-stage renal disease and face the prospectYou have end-stage renal disease and face the prospectof being on dialysis for the remaining 40 years of yourof being on dialysis for the remaining 40 years of your

    lifelife

    You are offered a hypothetical intervention (e.g. aYou are offered a hypothetical intervention (e.g. a

    xenograft) that will involve the gamble:xenograft) that will involve the gamble:

    Immediate return toImmediate return to

    full healthfull health

    (probability = p)(probability = p)

    Immediatedeath

    (probability = 1-p)

    Standard Gamble (SG)Standard Gamble (SG)

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    Standard Gamble (SG)Standard Gamble (SG)

    Xenograft

    Status quo

    Death

    Full Health for 40 yrs

    Dialysis for 40 yrs

    p

    1-p

    Preference value of Being On Dialysis = pPreference value of Being On Dialysis = p

    ChoiceChoice

    certain

    Valuing health and non-healthValuing health and non-health

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    benefitsbenefits

    Willingness To Pay (WTP)Willingness To Pay (WTP)

    Discrete Choice Experiments (DCEs)Discrete Choice Experiments (DCEs)

    Willingness To Pay (WTP)Willingness To Pay (WTP)

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    Willingness To Pay (WTP)Willingness To Pay (WTP)

    Most common method of measuring benefits in cost-Most common method of measuring benefits in cost-benefit analysisbenefit analysis

    Utility you gain from a program represented byUtility you gain from a program represented bymaximum amount you would be willing to pay for themaximum amount you would be willing to pay for theprogramprogram

    E.g. a new drug improves your health from severeE.g. a new drug improves your health from severeasthma to full healthasthma to full health What is the maximum you would be WTP for that drug?What is the maximum you would be WTP for that drug?

    Willingness To Pay (WTP)Willingness To Pay (WTP)

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    Willingness To Pay (WTP)Willingness To Pay (WTP)

    Can a monetary value be placed on health?Can a monetary value be placed on health? monetary valuations often implicit e.g. personal choices,monetary valuations often implicit e.g. personal choices,

    physician choicesphysician choices

    can be explicit e.g. safety programs, cost-per-QALYcan be explicit e.g. safety programs, cost-per-QALY

    thresholdsthresholds

    WTP can be measured in terms of out-of-WTP can be measured in terms of out-of-

    pocket payments, taxations, insurancepocket payments, taxations, insurance

    Equity weights for ability to payEquity weights for ability to pay

    Discrete Choice ExperimentsDiscrete Choice Experiments

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    ((DCEsDCEs))

    Individuals asked to make pairwise choices betweenIndividuals asked to make pairwise choices betweenhypothetical scenarioshypothetical scenarios

    Scenarios describe benefits from programsScenarios describe benefits from programs

    Scenarios decomposed into attributes and levels ofScenarios decomposed into attributes and levels of

    different attributesdifferent attributes direct parallel to items and item responses in HRQoLdirect parallel to items and item responses in HRQoL

    instrumentsinstruments

    Unlike WTP, valuations of attributes can be brokenUnlike WTP, valuations of attributes can be broken

    down for the different parts of benefitsdown for the different parts of benefits

    Some research issuesSome research issues

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    Some research issuesSome research issues

    Complexity of taskComplexity of task Cognitive burden, realismCognitive burden, realism

    Sensitivity to method of elicitationSensitivity to method of elicitation Which is the gold standard method?Which is the gold standard method?

    Dealing with health states that are worse thanDealing with health states that are worse thandeath (negative utilities)death (negative utilities)

    Whose preferences count Community?Whose preferences count Community?Patients?Patients?

    Proxy measures of benefit - parent for childProxy measures of benefit - parent for child

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    Session 3Session 3

    Evaluating community/ socialEvaluating community/ social

    interventionsinterventions

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    Session 4Session 4

    Using economics in healthUsing economics in health

    servicesservices

    OverviewOverview

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    OverviewOverview

    Background and principlesBackground and principles

    Program budgeting and marginal analysisProgram budgeting and marginal analysis

    (PBMA)(PBMA)

    Case studies NHA and VIHACase studies NHA and VIHA International lessonsInternational lessons

    Background: priority settingBackground: priority setting

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    Background: priority settingBackground: priority setting

    Health organizations the world over are charged withHealth organizations the world over are charged with

    allocating resources within a limited funding envelopeallocating resources within a limited funding envelope

    Surveys in Canada (and elsewhere) have reported uncertaintySurveys in Canada (and elsewhere) have reported uncertainty

    amongst decision makers on how best to do thisamongst decision makers on how best to do this

    Key questionsKey questions

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    What is to be done when there are not enough resources to meet all needs?What is to be done when there are not enough resources to meet all needs?

    What alternatives exist to historical and/ or political allocation processes?What alternatives exist to historical and/ or political allocation processes?

    How can resources be shifted or re-allocated within existing budgets?How can resources be shifted or re-allocated within existing budgets?

    How can evidence be drawn on to support a priority setting process?How can evidence be drawn on to support a priority setting process?

    Key questionsKey questions

    E i i i lEconomic principles

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    Economic principlesEconomic principles

    Opportunity costOpportunity cost:: By investing in program A, some benefit lost by notBy investing in program A, some benefit lost by not

    investing in program Binvesting in program B

    MarginMargin About the next unit of resourcesAbout the next unit of resources

    I li ti f th i i lImplications of the principles

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    Implications of the principlesImplications of the principles

    To do more of some things, we have to take resourcesTo do more of some things, we have to take resources

    from elsewhere, by either:from elsewhere, by either:

    doing the same things at less cost; ordoing the same things at less cost; or

    taking resources from areas of (effective) caretaking resources from areas of (effective) care

    Measure costs and benefits of health careMeasure costs and benefits of health care

    Often aboutOften about how muchhow much rather thanrather than whetherwhether

    Ethical conditionsEthical conditions

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    Daniels & Sabin, 2002; Gibson,

    Martin & Singer, 2005a.

    124

    RELEVANCERELEVANCE Decisions based on reasons fair-mindedDecisions based on reasons fair-minded

    people can agree are relevant under thepeople can agree are relevant under thecircumstancescircumstances

    PUBLICITYPUBLICITY Reasons publicly accessibleReasons publicly accessible

    REVISIONREVISION Opportunities to revisit/revise decisions &Opportunities to revisit/revise decisions &mechanism to resolve disputesmechanism to resolve disputes

    EMPOWERMENTEMPOWERMENT Power differences minimized &Power differences minimized & effectiveeffectiveparticipation optimizedparticipation optimized

    ENFORCEMENTENFORCEMENT Mechanisms ensure 4 conditions metMechanisms ensure 4 conditions met

    Evolution of PBMAEvolution of PBMA

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    Evolution of PBMAEvolution of PBMA

    Economic framework to assist decision makers inEconomic framework to assist decision makers inmaking choices around limited resourcesmaking choices around limited resources

    Based on economic principles and can incorporateBased on economic principles and can incorporate

    ethical conditionsethical conditions

    Used in health care since 1970sUsed in health care since 1970s 100+ organizations internationally100+ organizations internationally

    Currently being used in health authorities in Alberta andCurrently being used in health authorities in Alberta and

    British Columbia; also piloting in the LHINsBritish Columbia; also piloting in the LHINs

    From principles to practice

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    1. What resources are available in total?

    2. In what ways are these resources currently spent?

    3. What are the main candidates for more resources andwhat would be their effectiveness?

    4. Are there any areas of care which could be providedto the same level of effectiveness but with lessresources, so releasing resources to fund candidatesin (3)?

    5. Are there areas of care which, despite being effective,should have less resources because a proposal in (3)is more effective (per $ spent)?

    From principles to practice

    Practical StepsPractical Steps

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    Practical StepsPractical Steps

    Determine aim and scope of activityDetermine aim and scope of activity

    Identify and map resource useIdentify and map resource use

    Form an advisory panelForm an advisory panel

    Define and weight decision making criteriaDefine and weight decision making criteria

    Identify options for investment and disinvestmentIdentify options for investment and disinvestment

    Evaluate investments and disinvestmentsEvaluate investments and disinvestments

    Validation and recommendationsValidation and recommendations

    Communication, evaluation, revisionCommunication, evaluation, revision

    Peacock et al. BMJ 2006

    Programme budgetingProgramme budgeting

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    Programme budgetingg g g

    Most health regions have utilization data; some regionsMost health regions have utilization data; some regionshave case costinghave case costing

    Unique identifiers enable linkage but across an entireUnique identifiers enable linkage but across an entireregion or province tends to beregion or province tends to be Big holes in community based servicesBig holes in community based services

    Physician fee for service data held centrallyPhysician fee for service data held centrally

    Limited linking of inputs to outputsLimited linking of inputs to outputs

    Some exercises jump right to marginal analysis, others takeSome exercises jump right to marginal analysis, others takethe time to generate map of activity and expenditurethe time to generate map of activity and expenditure

    Use of evidenceUse of evidence

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    DeterminingOperational Priorities:

    Identifying Marginsfor Change

    DeterminingOperational Priorities:

    Identifying Marginsfor Change

    PopulationNeeds

    Population

    Needs

    ProvincialProvincialRequirements /Requirements /

    TargetsTargets

    ProvincialProvincialRequirements /Requirements /

    TargetsTargets

    Rating options againstpre-defined criteria

    Rating options againstpre-defined criteria

    Stakeholder InputThe CommunityStaff / Doctors

    Board

    Stakeholder InputThe CommunityStaff / Doctors

    Board

    Financial DataFinancial Data

    Service UtilizationOutput / Outcomes Data

    Service UtilizationOutput / Outcomes Data

    Business PlanPriorities

    Business Plan

    Priorities

    PracticeGuidelines &Standards

    PracticeGuidelines &Standards

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    Expected OutcomesExpected Outcomes

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    Expected Outcomesp

    Primary benefit for PBMAPrimary benefit for PBMA Achieving real resource shifts that are consistentAchieving real resource shifts that are consistent

    with strategic decision-making objectiveswith strategic decision-making objectives

    Secondary benefits for PBMASecondary benefits for PBMA Evidence driven decisionsEvidence driven decisions

    Ownership of planning processOwnership of planning process

    Transparent and defensible decision makingTransparent and defensible decision making

    Clinician engagement and partnershipClinician engagement and partnership

    Gibson et al. JHSRP2006

    Canadian examplesCanadian examples

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    pp

    Chinook Health Region (Alberta)Chinook Health Region (Alberta) Surgery, chronic diseaseSurgery, chronic disease

    Headwaters Health Authority (Alberta)Headwaters Health Authority (Alberta) Surgery, long term careSurgery, long term care

    Calgary Health Region (Alberta)Calgary Health Region (Alberta) Macro, childrens servicesMacro, childrens services

    Vancouver Island Health Authority (BC)Vancouver Island Health Authority (BC) Macro, within portfoliosMacro, within portfolios

    Interior Health Authority (BC)Interior Health Authority (BC) Community care servicesCommunity care services

    Northern Health Authority (BC)Northern Health Authority (BC) Home and community careHome and community care

    BC Cancer Agency (BC)BC Cancer Agency (BC) Screening, select drug therapiesScreening, select drug therapies

    North West, Central West and Champlain LHINsNorth West, Central West and Champlain LHINs

    Urgent priorities, Aging at Home, Alternative levels of careUrgent priorities, Aging at Home, Alternative levels of care

    Northern Health AuthorityNorthern Health Authority

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    yy

    Scope: all non-hospital H&CC servicesScope: all non-hospital H&CC services

    Participants: range of clinicians, managers and financeParticipants: range of clinicians, managers and financepersonnelpersonnel

    Objective: recommendations for allocation and re-allocation toObjective: recommendations for allocation and re-allocation toimpact 2007/08 budget yearimpact 2007/08 budget year

    Timeline:Timeline: May 17 decision maker training workshopMay 17 decision maker training workshop June form advisory panelJune form advisory panel

    July formulate and validate decision criteriaJuly formulate and validate decision criteria

    Aug/ Sept generate investment and release optionsAug/ Sept generate investment and release options

    Sept. 26 decision making retreatSept. 26 decision making retreat

    Oct. recommendations to ExecutiveOct. recommendations to Executive Nov/ Dec. evaluation and process refinementNov/ Dec. evaluation and process refinement

    Home & Community CareHome & Community Care

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    Home & Community CareHome & Community Care

    Criteria defined and assigned weightsCriteria defined and assigned weights

    Health gain, access, appropriateness, strategic alignmentHealth gain, access, appropriateness, strategic alignment

    Scoring of proposals for investment and resource release onScoring of proposals for investment and resource release on

    quantitative score sheetquantitative score sheet

    Scores entered into decision analysis softwareScores entered into decision analysis software

    Transferred to excel to present benefit scoresTransferred to excel to present benefit scores

    Recommendations for re-allocation, endorsed by SeniorRecommendations for re-allocation, endorsed by Senior

    ExecutiveExecutive

    Evaluation and refinements for next yearEvaluation and refinements for next year

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    SUB-CRITERIASUB-CRITERIA GUIDELINES FOR SELF-RATINGGUIDELINES FOR SELF-RATING Rating (1-Rating (1-9)9)

    0=opinion; 1=some0=opinion; 1=someevidence; 2=high qualityevidence; 2=high quality

    evidenceevidence

    11 22 33 44 55 66 77 88 99

    i) incremental health gain -i) incremental health gain -magnitude of health gain asmagnitude of health gain asmeasured bymeasured by relevant clinicalrelevant clinicaloutcomesoutcomes resulting from the initiativeresulting from the initiativecompared to current practices &compared to current practices &available servicesavailable services

    no difference in outcomesno difference in outcomescompared with currentcompared with current

    practices/servicespractices/services

    minimal improvement tominimal improvement tooutcomes compared withoutcomes compared withcurrent practices/servicescurrent practices/services

    moderate improvement tomoderate improvement tooutcomes compared withoutcomes compared withcurrent practices/servicescurrent practices/services

    high improvement tohigh improvement tooutcomes compared withoutcomes compared withcurrent practices/servicescurrent practices/services

    vast improvement tovast improvement tooutcomes compared withoutcomes compared withcurrent practices/servicescurrent practices/services

    ii) anticipated impact - theii) anticipated impact - theincremental improvement theincremental improvement theinitiative will have on clientsinitiative will have on clients healthhealthand quality of life and performanceand quality of life and performance

    no difference on quality ofno difference on quality oflife and performancelife and performance

    compared with currentcompared with currentpractices/servicespractices/services

    minimal improvement onminimal improvement onquality of life andquality of life and

    performance comparedperformance comparedwith currentwith current

    practices/servicespractices/services

    moderate improvementmoderate improvementon quality of life andon quality of life andperformance comparedperformance comparedwith currentwith currentpractices/servicespractices/services

    high improvement onhigh improvement onquality of life andquality of life andperformance comparedperformance comparedwith currentwith currentpractices/servicespractices/services

    vast improvement onvast improvement onquality of life andquality of life and

    performance comparedperformance comparedwith currentwith current

    practices/servicespractices/services

    iii) early intervention - likelihood thatiii) early intervention - likelihood thatearly intervention will reduce the riskearly intervention will reduce the riskof complicationsof complications

    0-11%0-11% 12-23%12-23% 24-35%24-35% 35-46%35-46% 47-58%47-58% 59-70%59-70% 71-82%71-82% 83-94%83-94% >95%>95%

    iv) target population - # ofiv) target population - # ofincrementalincremental clients to be servedclients to be servedannuallyannually by the initiative divided byby the initiative divided by# of# ofnewnew clients with this condition/clients with this condition/

    disease in NH regiondisease in NH region

    0-11%0-11% 12-23%12-23% 24-35%24-35% 35-46%35-46% 47-58%47-58% 59-70%59-70% 71-82%71-82% 83-94%83-94% >95%>95%

    (see Excel spreadsheet)

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    Vancouver Island Health AuthorityVancouver Island Health Authority

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    Vancouver Island Health AuthorityVancouver Island Health Authority

    750,000 population750,000 population

    17,000 employees17,000 employees

    All of Vancouver IslandAll of Vancouver Island

    $1.5 billion operating budget (excluding Phys costs)$1.5 billion operating budget (excluding Phys costs)

    114 service delivery sites114 service delivery sites

    Strategic planning, commissioning and provider roleStrategic planning, commissioning and provider role

    Entire continuum of care - primary care to tertiary careEntire continuum of care - primary care to tertiary care

    PBMA implementationPBMA implementation

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    PBMA implementationPBMA implementation

    For the past two years, VIHA has used PBMA in collaborationFor the past two years, VIHA has used PBMA in collaboration

    with researchers from UBCwith researchers from UBC

    Goals of PBMA in VIHA:Goals of PBMA in VIHA: Engage the organization, including physician leadershipEngage the organization, including physician leadership

    Transparent and evidence-based processTransparent and evidence-based process

    Greater understanding of the need to make choicesGreater understanding of the need to make choices

    Achieve greater support for decisionsAchieve greater support for decisions

    VIHAs 2007/08 ProcessVIHAs 2007/08 Process

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    VIHA s 2007/08 ProcessVIHA s 2007/08 Process

    Each portfolio presents their service growth and reductionEach portfolio presents their service growth and reduction

    opportunities using business case template; assessment againstopportunities using business case template; assessment against

    criteriacriteria

    Proposals scored by peers (senior management team)Proposals scored by peers (senior management team)

    Ranking using formal benefit scoring toolRanking using formal benefit scoring tool

    Marginal analysis trade-off decisions on relative value of releases vs.Marginal analysis trade-off decisions on relative value of releases vs.

    investmentsinvestments

    Final list validated by the groupFinal list validated by the group

    Recommendations to Executive and/ or BoardRecommendations to Executive and/ or Board

    Evaluation CriteriaEvaluation Criteria

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    Patient/Client Safety Healthy Workplace

    Access and FlowClient/Patient Focus

    Health and Wellness

    Net Revenue/ In-kind ResourcesEfficiency

    Differential weighting across the criteria

    a ua o C e afor Proposalsfor Proposals

    VIHA 2007/08 PVIHAs 2007/08 Process

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