Healing & Repair

Dr Sameh Abou-Beih Lecturer of Pathology

Fayoum University

Types of Cells

• Labile

• Stable

• Permanent

• Stem cells

Factors affecting repair

• General – Age – Debilitating conditions – Ptn deficiency – Vitamin & trace element deficiency – Drugs

• Local – Severity – Cell type – Bl supply – Infection & FB

Growth factors

Healing by fibrosis

• Angiogenesis

• Fibrogenesis

• Maturation of scar

• Remodelling of fibrous tissue

Examples of healing

Complication of Wound Healing

• Ulcer

• Fistula

• Sinus

• Implantation

• Keloid

• Contractures

• Carcinoma

Causes of Malunion

• Local

– Infection

– Poor opposition

– Mobilization

– Poor bl supply

• General

– Old age

– Malnutrition

Thank You