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Health research in Norway Research Council of Norway Aleksandra Witczak Haugstad, senior adviser Division for Health and Society
Health research in Norway
Research Council of NorwayAleksandra Witczak Haugstad, senior adviser Division for Health and Society
Outline
• Who funds and who conducts healthresearch in Norway?
• In which research areas does healthresearch take place?
• Which types of support and arenas for competition exist for health research in Norway?
• In which international and European arenas and platforms for healthresearch does Norway participates?
Funding and actors
Research investment Institutional landscape Stragies and policies
R&D expenditure to HE and institute sector by fields of science
*MNOK and per cent 2015 (~820 mill EUR to medical and health sciences)
Source: HealthCare21 monitor
Horizon2020
RCN Cancer society
Regional health
authorities
42MEUR
2111 31
63MEUR
11 31 42
Who performs health research in Norway?
Source: Helseomsorg21monitor.no
Universities and University Hospitals
University of Bergen
University of
Tromsø
Norwegian University of Science and
Technology (NTNU, Trondheim)
University of Oslo
Norwegian Institute of
Public Health (NIPH)
University
Hospital
University
Hospital
University
Hospitals
5 Norwegian Regional
Hospital Authorities
University Hospitals
HealthCare21-strategy – government action plan
Health&Care21 : Main priorities
1. Knowledge mobilisation for the municipalities.
2. Health care as a focus area of industrial policy.
3. Easier access to, and increased utilisation of
health data.
4. An evidence-informed health and care system
based on user involvement and competence.
5. A strong commitment to internationalisation and
increased participation in the competitive
European research system
Research Funding Measures
Funding for research
Types of support
Instruments and arenas for competition
Instruments for Health Research: Health Research programmes at RCN
Health, care and welfare services research (HELSEVEL)health, care and welfare services, ensures good patient and user pathways based on the users’ needs
High-quality and Reliable Diagnostics, Treatment and Rehabilitation (BEHANDLING), clinical research activities , diagnostics, treatmentand rehabilitation
Better Health and Quality of Life (BEDREHELSE) improve public health, enhance quality of life, reduce social inequalities in health.
Global Health and Vaccination Research (GLOBVAC)sustainable improvements in health and health equity for poor people in low- and lower-middle income countries (LMIC).
Find current projects at prosjektbanken.no
has funded >30 research infrastructure projects whichfacilitates use and sharing of research data
National Financing Initiative for Research Infrastructure
Biobank Norway www.ntnu.edu/biobanknorwayFreezing systems, automated storage and retrieval solutions for human biosamples, easier connection to health data, biobank registry, cohort explorer, secure ICT solutions, innovation, ethics, … Norwegian BBMRI-ERIC node
Health Registries for Research https://hrr.w.uib.no/The project will• promote safe and efficient use of Norwegian health records in research • provide better access to data and better quality of data and metadata • develop standards for how to register data
Health Analysis Platform https://ehelse.no/helsedataprogrammet• aims to facilitate easier access to health data by investigating and establishing a
national infrastructure for the availability and analysis of health data• Additionally improve data quality, easier data reporting and automation of
management
ELIXIR-EMBL
ERIC ERIC
ERIC
ESFRIs and ESFRI ERICs Biomedicine, biology and health
NCS-PM: National consortium for sequencing and personalized medicine
Partners: UOS, UiO, UiB, NTNU, Haukeland University Hospital
NNP: Norwegian NMR Platform (nuclear magneticresonance)Partners: UiB, UiO, NTNU
NorMITNorwegian Centre for Minimally Invasive Image Guided Therapy and Medical Technologies
Partners: St Olavs Hospital, NTNU, SINTEF, UiO, OUS
National infrasturctures
CELLMASS: Norwegian Mass Cytometry Infrastructurefor Single Cell Analysis in Immunology and Cancer Biology
Partners: UiB, UiT, UiO, HELSE-Bergen, OUS
NORBRAIN : Norwegian Brain Initiative
Partners: NTNU, UiO
E-INFRA 2014 – a national e-infrastructure for sciencePartners: Uninett Sigma 2, UiT, UiO, NTNU, UiB
Norwegian Centers of Excellence
Centre for Immune Regulation (CIR)
Center for Cancer Biomedicine (CCB)
Centre for Molecular Biology and Neuroscience (CMBN)
Centre for the Biology of Memory (CBM)
2003
2007
Norwegian Centers of Excellence 2013
Norwegian Centre for Mental DisordersResearch (NORMENT)
Centre for Cancer Cell Reprogramming(CanCell)
Centre for Fertility and Health (CFH)
Centre for Intervention Science in Maternal and Child Health (CISMAC)
Centre for Cancer Biomarkers (CCBIO)
Centre for Molecular Inflammation Research (CEMIR)
Centre for Neural Computation (CNC)
2017
Centres for Research-based Innovation (SFI)
New centre scheme:Centres for Clinical Treatment Research (FKB)
Establish clinical research groups that carry out top-calibre research to improve patient treatment
Broad spectre of interventions
Selection of centres based on:
scientific merit
internationalisation
relevance and benefit to patient treatment
Funding announced for one centre
serious diseases affecting the central nervous system (such as amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS) and dementia)
Clusters for innovation in health and medicine
19.02.2018
Kolumnetittel
21
• Oslo Cancer Cluster
• Norway Health Tech
• Norwegian Smart Care Cluster
H2020 projects with Norwegian participation
54
146
256
409
99 112
44
399
8165
400
498469
404376
100
139
0
100
200
300
400
500
600
All støtte (mill. euro) Derav norsk støtte…
SC1 Health…– results for 2017-topics improving successrates
ERA-net Cofunds and art.169/185 with Norwegian participation
ERA PerMed Personalised Medicine
HBM4EU European Human Biomonitoring Initiative
JPI-EC-AMR Synergies with JPI on Antimicrobial Resistance Research
ERA-CVD Cardiovascular diseases
ERAcoSysMed Systems biology approaches in clinical research and medical practice
JPco-fuND Synergies with JPND
TRANSCAN-2 Aligning translational cancer research
AAL 2 Active and Assisted Living
EDCTP2 European & Developing Countries Clinical Trials Partnership
Norwegian ERC granteesin Life Sciences
6 ERC grantees in Applied Medical Technologies, Diagnostics, Therapies, and Public Health (LS 7)
2017: Kyrre Eeg Emblem (Oslo Uni Hospital)
2017: May-Britt Tessem (NTNU)
6 ERC grantees in Neuroscience and Neural Disorders (LS 5)
2 ERC grantees in Physiology, Pathophysiology and Endocrinology(LS 4)
1 ERC grantee :
Cellular and Developmental Biology (LS 3)
Immunity and Infection (LS 6)
«The ERC is definately one of ourmost important sources of research
funding becouse the ERC exclusively rewards merit in
research», say May-Britt and Edvard Moser.
Norwegian ERC grantees in panels LS 3-7
Call Navn InstitusjonTittel Panel
2008-AdG Harald Alfred Stenmark UiO
The PI3K-III complex: Function in cell regulation and
tumour suppression (PI3K-III COMPLEX) LS3: Cellular and Developmental Biolog
2007-StG Ayumu Tashiro NTNU
Understanding computational roles of new neurons
generated in the adult hippocampus (AN07AT) LS4:Physiology, Pathophysiology and Endocrinology
2014-CoG William LOUCH UiO Controlling Cardiomyocyte Dyadic Structure LS4
2008-AdG Edvard Ingjald Moser NTNU
Neural circuits for space representation in the
mammalian cortex (CIRCUIT) LS5:Neuroscience and Neural Disorders
2010-AdG May Britt Moser NTNU Neural mechanisms for memory retrieval (ENSEMBLE) LS5
2013-StG Jonathan Whitlock NTNU
Deconstructing action planning and action observation
in parietal circuits in rats LS5
2013-StG Emre Yaksi NTNU Function of Chemosensory Circuits LS5
2013-AdG Edvard Ingjald Moser (2)NTNU Cortical maps for space LS5
2014-StG Koen VERVAEKE UiO
The role of 5HT3a inhibitory interneurons in sensory
processing (SurfaceInhibition) LS5
2010-AdG Ludvig Magne Sollid UiO
Coeliac disease: understanding how a foreign protein
drives autoantibody formation (AUTO-CD) LS6:Immunity and Infection
2008-AdG Eiliv Lund UiTø Transcriptomics in cancer epidemiology (TICE) LS7:Applied Medical Technologies, Diagnostics, Therapies, and Public Health
2011-AdG Pål Rasmus Njølstad UiB LS7
2013-CoG Frederik Frøen FHI
A New Paradigm for Public Health Surveillance:
Unlocking the Potential of Data to Empower Women
and Health Systems LS7
2014-StG Hedvig NORDENG UiO
Effects of Medication Use in Pregnancy on Infant
Neurodevelopment (DrugsInPregnancy) LS7
2017-StG Kyrre Eeg Emblem OUS Imaging Perfusion Restrictions from Extracellular Solid LS7
2017-StG May-Britt Tessem NTNU
'Tissue is the issue': a multi-omics approach to
improve prostate cancer diagnosis LS7
Message
• Health is a prioritesed area for researchin Norway
• A number of groups and centres are ofhigh quality and take part in international networks
• To identify relevant parnters useresources and advice
How to identify a partner?
Euraxess.no
H2020 projects
RCN projects – prosjektbanken.no
Infrastructure
Centres
Alzheimer’s disease and other dementias
Parkinson’s disease Prion disease Motor neurone diseases
Huntington’s disease
SCA and SMA
Basic researchImprove the scientific understanding of the disease
Health and CareImprove the social care and structures available to assist patients, their families, and health service providers so that patients receive optimum care
at all stages of their illness
Clinical research Improve the medical
tools available toidentify and treat the
disease
30 countries, incl. Canada, Australia, Switzerland, Israel
Norwegian budget: NOK 9 mill. per year
EU Joint Programme –Neurodegenerative Disease Research
EU Joint Programme –Neurodegenerative Disease Research
Research Database 2011 – updated in 2016
Contains some 2500 projects and infrastructures in member counties
http://www.neurodegenerationresearch.eu/search-our-database/
Experimental Models for Parkinson’s disease
In vitro models, in vivo mammalian and non-mammalian models
Latest updates on state-of-the-art of the models
Real-time discussions
http://www.neurodegenerationresearch.eu/models-for-parkinsons-disease/
Global Cohort Portal A searchable catalogue of cohort studies that covers both disease-focused
and general population studies
110 cohorts included in 2017, another 100 will come
http://www.neurodegenerationresearch.eu/jpnd-global-cohort-portal/
EU Joint Programme –Neurodegenerative Disease Research
Propagation behaviour of peripheral amyloid-beta towards brain structures: effects of the blood-brain barrier
Jens Pahnke, Oslo University Hospital
Synaptic circuit protection in AD and HD: BDNF/TrkB and Arc signaling as rescue factors
Clive Bramham, University of Bergen
Pre-clinical genotype-phenotype predictors of Alzheimers disease and other dementia
Tormod Fladeby, University of Oslo
COmprehensive Unbiased Risk factor Assessment for Genetics and Environment in Parkinson's Disease
Mathias Toft, Oslo University Hospital
JPIAMR web site: http://www.jpiamr.eu/
Norwegian JPIAMR web site:
http://www.forskningsradet.no/prognett-JPIAMR/Forside/1254010892673
The mission:
The JPI on AMR will develop integrated approaches to pursue unique world-class research on AMR that will be translated into new prevention and intervention strategies to improve the public health and wellbeing of populations, and deliver economic and societal benefit both in Europe and globally.
Budget: 6,6 NOK per year from 2014 (HOD)
JPIAMR (2013-2017)EU Joint Programming Initiative on Antimicrobial Resistance
JPIAMR
Ongoing projects with Norwegian participantsProsject title Norwegian PI Institution
JPIAMR 1
2015 2017
New intervention strategy for tuberculosis: blocking multiple essential targets
Magnus SteigedalNorwegian University of Science and Technology - NTNU
Nettverk
2017 2018
Network on quantification of antimicrobial consumption in animals at farm level and analysis, communication and benchmarking to improve use
Kari Grave Norwegian Veterinary Institute
Nettverk2017 2018
Behavioural approaches to optimise antibiotic stewardship in hospitals
Ingrid Smith Health Bergen HF
JPI-EC-AMR 1
2017 2019
The rates and routes of transmission of multidrug resistant Klebsiella clones and genes into the clinic from environmental sources.
Jukka Corander University of Oslo
JPI-EC-AMR 1
2017 2020
Using collateral sensitivity to reverse the selection and transmission of antibiotic resistance
Pål Jarle JohnsenThe Artic University of Norway – UiT
JPI-EC-AMR 12017 2019
Wastewater treatment plants as critical reservoirs for resistance genes
Roald Kommedal University of Stavanger
JPI-EC-AMR 22018 2024 Improving rational prescribing for UTI in frail elderly Morten Llindbæk University of Oslo
JPI-EC-AMR 2
2018 2020
Impact of Prescription Quality, Infection Control and Antimicrobial Stewardship on Gut Microbiota Domination by Healthcare-Associated Path. Gunnar Skov Simonsen
UNN – University Hospital, North Norway
JPI-EC-AMR 2
2018 2020
Piloting on-site interventions for reducing antimicrobial use in livestock farming in emerging economies Marianne Sunde Norwegian Veterinary Institute
ERA-CVD – European Research Area Network on Cardiovascular Diseases
Projects from calls 2016 and 2017 with Norwegian partners:
PDE4Heart: Gene therapy with phosphodiesterases to treat heart failure
Finn Olav Levy, University of Oslo
AtheroMacHete: Macrophage heterogeneity in human and murine atherosclerosis: a therapeutic opportunity
Pål Aukrust, UiO
XploreCAD: Advanced ex vivo analyses and multi-frequency ultrasound technology for improved evaluation and diagnosis of coronary plaque
Rune Hansen, SINTEF
ERA-Net TRANSCAN 2 – Aligning national/regional
translational cancer research programmes and activities
Projects from 2016 call with Norwegian partners:
Exploitation of extracellular vesicles for precision diagnostics of prostate cancer.
Alicia Lorente, Oslo University Hospital
Microbiota-based SCReening of Anal Cancer in HIV-infected individuals (SCRAtCH)
Marius Trøseid, Oslo University Hospital
Minimally and non-invasive methods for early detection and/or progression of cancer
Rolf Bjerkvig, University of Bergen
ERA-NEURON - basic, clinical and translational research in disease-related neuroscience
Project from 2017 call with Norwegian partners:
Linking synaptic dysfunction to disease mechanisms in schizophrenia - a multi-level investigation
Understanding psychosis, cognitive impairment and motor symptoms induced by NMDA receptor dysfunction
Ole A. Andreassen, Oslo University Hospital
Mechanisms of neuropsychiatric genetic diseases of the SNARE complex: towards therapeutic intervention
Camila Esguerra, University of Oslo
Mapping and interrogating top-down control of the memory engram of the posttraumatic stress disorder
Stephanie Le Hellard, University of Oslo
Health and Care for the 21. century
Health&Care21
Theknowledge
triangel
Bedrefolkehelse
Ressurs-effektivitet
Godebrukererfaringer
Break-throughresearch
National economic
and business development
Betterpublichealth
Innovation Education
R&D
Medical and health research in RCN –funding instruments
Independent Projects (non-thematic schemes)
Evaluation criterion: Scientific quality
Research Programmes
Thematically defined, clear goals, topic priorities
Evaluation criterion: Scientific quality and programme relevance
Min. of Research and Education
Min. of Health and Care Services
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NCS-PM: National consortium for sequencing and personalized medicinePartners: UOS, UiO, UiB, NTNU, Haukeland University Hospital
NALMIN: Norwegian Advanced Microscopy Imaging NetworkOne of Norwegian nodes of Euro-BioImagingPartners: UiO, OUS, UiT, UiB, NTNU
NOR-OPENSCREENNorwegian EU-OPENSCREEN-nodePartners: UiO, UiT, UiB, SINTEF Materials and Chemistry
NNP: Norwegian NMR Platform (nuclear magnetic resonance)Partners: UiB, UiO, NTNU
CELLMASS: Norwegian Mass CytometryInfrastructure for Single Cell Analysis in Immunologyand Cancer Biology
Partners: UiB, UiT, UiO, HELSE-Bergen, OUS
ELIXIR.no Partner in ESFRI ELIXIR
Partners: UiB, UiO, NTNU, UiT, NMBU
NORBRAIN : Norwegian Brain Initiative
Partners: NTNU, UiO
BIOBANK NORWAYPartner in ESFRI BBMRI
Partners: NTNU, FHI, UiO, UiT, UiB and Regional Health Authorities
E-INFRA 2014 – a national e-infrastructure for sciencePartners: Uninett Sigma 2, UiT, UiO, NTNU, UiB
EATRIS Centre Norway: A Norwegian Node for the European Advanced Translational Research Infrastructure in Medicine
Partners: UiO, OUS, UiT, UiB, NTNU
NorCRINNorwegian Clinical Research Infrastructure NetworkPartner in ESFRI: ECRIN
Partners: St Olavs Hospital, Haukeland univ.hospital, HelseStavanger, UNN, OUS, AHUS
NorMITNorwegian Centre for Minimally Invasive Image Guided Therapy and Medical Technologies
Partners: St Olavs Hospital, NTNU, SINTEF, UiO, OUS
HELSEREGISTREHealth Registries for Research
Partners: UiB, Haukeland univ.hospital, Helse Stavanger, UNN, OUS, AHUS
0
1,000
2,000
3,000
4,000
5,000
6,000
1970 1975 1980 1985 1990 1995 2000 2005 2010 2015
Humanities
Social Sciences
Math. & Natural Sciences
Medicine and health
Agricultural Sciences
Technology
Source: NIFU
Expenditure on R&D by field of science 1985-2011
(Higher Education and Institute sector). Constant 2011 prices.
mill. NOK
Institutional landscape
Higher Education Institutions
Regional Health Authorities
Research institutes
Information and links at EURAXESS.no
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