JoVE, the Journal of Visualized Experiments, is the first and only peer reviewed PubMed/Medline indexed journal devoted
to the publication of scientific research in a video format. Since 2006 JoVE has been publishing video articles from
laboratories around the world about a variety of scientific disciplines. JoVE also recently introduced Science Education, a
video database to teach laboratory fundamentals. JoVE helps to visualize the complex world of science to increase
educational outcomes, speed learning of lab protocols and methods, and provide a visual basis to accompany traditional
teaching and learning. From basic protocols to specific images and videos that can be used in class, JoVE offers
something for everyone.
The benefits of a JoVE subscription include:
With JoVE, you can provide your school with a 21st century solution for teaching and learning science.
For more information contact your account manager today at [email protected] or call 617-945-9051.
60 new video articles published monthly
Perpetual access to content published during your subscription
Access to archived content
Subscription customized for the sections you require
Guaranteed set price for 3 renewal periods
Unlimited simultaneous users
IP authentication for campus-wide access
Ability to purchase as a monograph, one-time purchase or serials purchase
Authors are provided with a copy of their article for educational, non-commercial use
Scientists can preserve the technique used in their own labs, even after postdocs leave
JoVE helps others understand nuances that may be lost in a print protocol
Techniques can be shared with collaborators without traveling
Authors are able to access viewer statistics not available with traditional journals
Video articles on JoVE get 10,000+ quality views per year
How authors publish in JoVE
Authors write text manuscript using the provided template and submit online. The article will be editorially
and peer reviewed. If accepted, JoVE will script and prepare for filming. Pre-production takes 7-10 weeks.
PRE-PRODUCTION
Our experienced videographers film at the lab. Video can be captured from microscopes, computer
screens, and even underwater. A filming typically takes a full day.
FILMING
After filming, our video team will edit the video, animate schematics, and record voiceovers. The video is
then returned to the author(s) for review. Post production takes 2-3 months.
POST PRODUCTION
Once post production is complete an article is put on the publication calendar and will soon appear on
www.JoVE.com
PUBLISHING
Benefits of publishing in JoVE
JoVE General
JoVE: General is our primary reference resource which includes techniques and protocols from biological, medical,
chemical and physical research. Areas of techniques covered include, but are not limited to:
Developmental Biology
Molecular biology
Bioinformatics
Marine biology
Environmental biology
Veterinary medicine
Non-pathogenic microbiology
Plant Biology
JoVE Neuroscience
JoVE: Neuroscience includes techniques from a wide variety of fields, focusing on those intended to lend insight into the
structure, function, physiology and pathophysiology of the central and peripheral nervous systems. Areas of techniques
covered include, but are not limited to:
Systems neurobiology
Electrophysiology
Development and neural plasticity
Cellular and molecular neurobiology
Animal behavioral testing
Human and animal brain imaging
Psychophysics
Neurobiology of disease
JoVE Immunology and Infection
JoVE: Immunology and Infection includes video articles demonstrating seminal and novel techniques in the fields of
immunology and infectious diseases. The scope of the section includes but is not limited to protocols that address the
following topics:
Basic biology of pathogenic bacteria, fungi, parasites, viruses, and infectious prions
Biology and roles of vectors in microbe life cycles
in vitro and in vivo modeling of pathogenesis
JoVE Journal Sections
JoVE Clinical and Translational Medicine
JoVE: Medicine is a primary reference and educational resource for scientists and physicians. Articles typically document
medical procedures, case reports, clinical trials and translational medicine with direct bedside application. Areas of
techniques covered include:
Animal models of diseases
Surgical subspecialties
Internal medicine
Clinical trials
Behavioral health
Best medical practice
Medical and nursing teaching resources
JoVE Bioengineering
JoVE: Bioengineering focuses on techniques in which the principles of engineering, mathematics and physics
are applied to problems associated with the life sciences. This rapidly growing area of research includes but is
not limited to:
Advanced Instrumentation
Cell and Tissue Engineering
Computational Biology
Synthetic Biology
Bio-MEMS and Microfluidic Devices
Nanotechnology
Biomimetics and Biomaterials
Cybernetics
G
Immune response to infection and tumors
Immune cell development
Autoimmune responses and diseases
Allergic diseases
JoVE Applied Physics
JoVE: Applied Physics focuses on the experimental disciplines within physics, as well as mechanical and electrical
engineering. Interdisciplinary fields such as materials science and chemical physics are welcomed. Instrumentation is
encouraged from all fields especially optics, photonics, and astronomy. The scope of the section includes but is not limited to:
Atomic, molecular, and optical physics
Condensed matter physics
Solid state physics
Plasma physics
Fluid mechanics
Mechanical engineering
Electrical engineering
Materials science and engineering
Organic chemistry
Inorganic chemistry
Physical chemistry
Analytical chemistry
Biochemistry
Chemical biology
Molecular biology
Preparation, use, and analysis of novel materials and structures
Spectroscopic techniques
Molecular self-assembly and recognition
JoVE Chemistry
JoVE: Chemistry focuses on the methodology within chemistry and chemical preparation within multidisciplinary fields.
The chemistry section welcomes articles about new methodologies and new twists on existing methodologies.
The scope of this section includes but is not limited to:
Cognition (Attention, Decision Making, Reasoning)
Sexual and Motivational Behaviors
Social Behaviors
Learning and Memory
Sleep and biological rhythms
Language Processing
JoVE Behavior
JoVE Behavior includes both observational and experimental techniques that seek to understand human and animal behavior,
implicated brain regions, related physiological changes, and underlying genetic causes. The scope of section includes but is
not limited to:
Addiction
Emotion
Control of Movement
Consciousness
Renewable energy and sustainable materials
Environmental engineering
Basic and applied ecology
Ecotoxicology and ecological health
Marine biology and oceanography
Soil and agricultural sciences
Forestry and botany
Atmospheric science and climate modeling
Geosciences
JoVE Environment
JoVE Environment is a multidisciplinary section devoted to the publication of research methods employed in environmental
science and green technologies, from biofuels to oceanography to atmospheric sciences. Special consideration is given to
experimental techniques and approaches aimed at understanding the Earth, protecting natural resources and creating a more
sustainable and environmentally-conscious planet.
The scope of this section includes but is not limited to:
An Introduction to the Centrifuge
Introduction to the Microplate Reader
Understanding Concentration and Measuring Volumes
Making Solutions in the Laboratory
An Introduction to the Micropipettor
Science Education
Science Education Collections
JoVE Science Education is a revolutionary video database dedicated to teaching laboratory fundamentals through video
demonstrations. Each collection features 15 videos showing an overview of a technique or instrument. Every video is paired
with additional video resources to illustrate practical applications and complementary skills.
General Laboratory Techniques
Using a Hemacytometer to Count Cells
Passaging Cells
PCR: The Polymerase Chain Reaction
DNA Gel Electrophoresis
Separating Protein with SDS-PAGE
Bacterial Transformation: The Heat Shock Method
Bacterial Transformation: Electroporation
The ELISA Method
Plasmid Purification
Gel Purification
The Western Blot
An Introduction to Transfection
DNA Ligation Reactions
Restriction Enzyme Digests
Molecular Cloning
Basic Methods in Cellular and Molecular Biology
An Introduction to Saccharomyces cerevisiae
An Introduction to Drosophila melanogaster
An Overview of the Model Organism: C. elegans
Model Organisms I
Introduction to Serological Pipettes and Pipettors
Introduction to the Bunsen Burner
An Introduction to Working in the Hood
Measuring Mass in the Laboratory
Introduction to the Spectrophotometer
Histological Sample Preparation for Light Microscopy
Introduction to Fluorescence Microscopy
Introduction to Light Microscopy
Regulating Temperature in the Lab: Preserving Samples Using Cold
Regulating Temperature in the Lab: Applying Heat
Yeast Maintenance
Yeast Reproduction
Yeast Transformation and Cloning
Isolating Nucleic Acids from Yeast
Drosophila Maintenance and Care
Drosophila Development and Reproduction
Drosophila Embryo Larva
Drosophila Larval IHC
C. elegans Maintenance
Caenorhabditis elegans Development and Reproduction
RNAi in C. elegans
C. elegans Chemotaxis Assay
Novel results compel researchers to pursue unfamiliar,
interdisciplinary experiments.
In the course of scientific discovery, results from one set of
experiments will often necessitate new questions and new, cross
disciplinary experiments. “We had a discovery about five years ago
concerning the role of the circadian system in the development of
the mammary glands and lactation,” Dr. Casey says. The circadian
system governs many cyclical processes in mammalian bodies,
including the sleep/wake cycle and has the reproductive cycles.
These are known commonly as circadian rhythms, and are governed
by the suprachiasmatic nucleus, a group of cells in the
hypothalamus region of the mammalian brain.
“I’ve been doing research for 20 years,
and having JoVE makes things so much easier. JoVE leads to better
results and saves a ton of money, time,
laboratory animals, and frustration!”
Who: Dr. Theresa Casey, Assistant Professor in the Department of
Animal Sciences at Purdue University and member of Dr. Karen
Plaut Lab.
Where: Purdue is a large university in West Lafayette, Indiana with
nearly 40,000 students in attendance each year.
If you are interesting in
adding JoVE as a resource
please contact us by emailing
or by calling
w w w . J o V E . c o m
While searching for methods papers describing how to dissect the suprachiasmatic nucleus in
mice, Dr. Casey and her colleagues discovered JoVE, the world’s first peer reviewed, pub-med
indexed video methods journal. “Once you can see how someone else does something, or see how
someone does something differently than you, it makes your work better,” Dr. Casey explains.
So far, Casey and her colleagues have used JoVE videos to accomplish three different goals in
their laboratory:
Dr. Casey and her colleagues are physiologists, and lacked the clinical neuroscience experience to
properly study the suprachiasmatic nucleus in mice. Other discoveries have caused the Plaut lab to
experiment with different model organisms including mice, rats and cows. Describing the
challenges faced in her lab, Dr. Casey says, “Picking the most appropriate model system is
difficult. In studying the interaction between circadian and mammary systems, we have had to look
in a lot of peripheral tissues.”
Dissection of the Suprachiasmatic Nuclei (SCN) from the hypothalamus – a technique
new to the lab.
Ex Vivo Measurement of Milk Let Down in mice – a new method to measure milk
production in mice.
Differentiation of HC-11 Cells in culture- a familiar technique that visualization helped
match results with previously published literature.
Dr. Casey explains that JoVE has saved the Plaut
Lab thousands of dollars, particularly in travel costs.
“I had a collaborator in Buffalo who knew the SCN
surgery, and I’ve seen it done before. By using the
JoVE video, we saved money in travel costs to go to
Buffalo repeatedly to learn the technique.” By using
Jove to learn the SCN dissection, $6300 was saved
in lost wages; $1100 was saved on travel; and $7700
in reagents. If JoVE helps other labs at Purdue
University save 1/10th of the amount saved by Plaut
Lab, JoVE would save Purdue University’s 100+
labs over $150,000 a year.
Wages $6231 Travel $1100
Reagents $7669
In other ways, JoVE is invaluable and helps make researchers better versed in their colleague’s work.
“I’ve been doing research for 20 years, and having JoVE makes things so much easier. You can
educate yourself on research other scientists are doing around you and get familiarized on a
technique before you try it. I like to watch techniques and refresh myself on experiments I haven’t
conducted in 18 years but need now.” For a seasoned researcher, learning a technique with JoVE is
10x faster than standard journals.
The Plaut lab is also preparing a paper for publication about how they have utilized the HC-11 cell
culture technique that the lab learned from JoVE.
0
10
20
30
40
Da
ys
The time it takes to learn a procedure
Seasoned Researcher
With JoVE (Days)
Without JoVE (Days)
Frequent Student Turnover Reduces Research Productivity.
Each year, as a new class of experienced researchers graduate in
the spring and first year students arrive in the fall, the Drew Lab
faces the reality of academia: student turnover. As new students
work on their own research projects, they turn to Lab Manager Ms.
Jeanette Moore for guidance. “New students will come in and say,
‘oh, you’ve done this experiment in the past, I’m going to take it and
use it here. Who can teach me how?’” Moore explains. When
someone currently at the University is familiar with the technique,
the students are helped immediately. “Often, no one is trained in the
techniques needed. In that case, we would spend up to six months
looking at text references to successfully complete an experiment.”
The problem is compounded by the fact that the Drew Lab works
“With traditional text publications, only descriptions of the experiment were
provided. What was really needed wasfor the experiment
to be shown. Actions teach better than words,
that is where JoVE comes in.”
Who: Jeanette Moore, Research Professional in the Dr. Kelly Drew
Lab at University of Alaska, Fairbanks.
Where: University of Alaska Fairbanks is a public research university
in Fairbanks, Alaska with a student population of 11034.
or by calling
w w w . J o V E . c o m
If you are interesting in
adding JoVE as a resource
please contact us by emailing
It’s important to have the conceptual understanding of what you are doing in an experiment, but as
Ms. Jeanette Moore tells us of text journals, “sometimes you’re reading directions, and the words
just don’t make sense. That is the value of JoVE, actually seeing how to insert a needle in a
laboratory animal before you do it so that you don’t have to do it twice.” JoVE’s peer-reviewed video
articles help Ms. Moore and her students achieve their research goals. While developing a drug
therapy for ischemia, Moore and her students turn to JoVE for instruction and tips for their
experiments. “While we have done blood perfusion and fluorescent immunohistochemistry in the
past, we’ve never done them together while trying to illicit a response to a drug therapy.”
“JoVE makes a difference in our ability to even do these experiments. Scientists are constantly
struggling to find someone to help them, and often not finding anyone. Being in Alaska, and relying
only on the experience of our staff, we’re limited in what we can do.”
JoVE’s ever-expanding library of nearly 2200 videos help Ms. Moore and her colleagues stay
up-to-date with the most efficient techniques to do their experiments and execute complex surgeries
while saving valuable time, money, and animal resources. The students love JoVE because it helps
them graduate on time and with publications they need for their career.
The lab is able to prepare a new paper for publication and has received three new grants thanks
to JoVE’s support.
Using JoVE has saved Ms. Moore and the Drew Lab months of trial and error, saved the laboratory
money, animal resources, and have led to new publications and three new grants. “Instead of trying to
learn a technique from the literature for six months, new researchers can master the method in a few
days. As such, everything is streamlined with JoVE. We use fewer expensive antibodies in our
research, we learn the techniques faster so we use fewer animals, you reduce the drugs you use on
the animals, and you get publishable results. The time saved helps ensure we can push students
through to graduation as well.” The lab saved thousands of dollars on the expensive cFos, GAD67 and
tyrosine hydroxylase. They also applied to NIH grant RO3 because of research achieved with JoVE.
with perfusion in animals. Longer periods of trial and error inevitably mean more animals sacrificed
for the research.
Laboratory techniques established as early as the 1980s are still
valuable in current research; however, few researchers are trained in
these techniques and they can be difficult to learn from traditional
literature.
Drosophila melanogaster, the common fruit fly, is a common animal
model for researchers studying biochemistry, genetics and
neuroscience. Flies have been used for over a century, but rose to
prominence after scientists established techniques to transgenically
manipulate the species genome in the late 1970s and early ‘80s. As
more and more research laboratories use flies, new scientists need
“JoVE videos make researchers become
experts in no time and move on to new experiments.”
Who: Nikolaos Giagtzoglou, Post Doctoral researcher in
neuroscience at Baylor College of Medicine. Currently in the Hugo
J. Bellen lab.
Where: Baylor College of Medicine, located in Houston, Texas, is a
graduate level institution focused on medical and biomedical
research with 1,211 students.
If you are interesting in
adding JoVE as a resource
please contact us by emailing
or by calling
w w w . J o V E . c o m
“I needed to learn three Drosophila techniques: giant fiber recording and dissection in Drosophila,
dissection of ovaries, and backfilling of motor neurons with calcium indicators. I really had no
starting point to learn these techniques, and JoVE was invaluable,” Dr. Giagtzoglou explains. The
worth of these techniques is inestimable when trying to understand adult fly neural structure and
function.
“Even when you meet someone who specializes in a technique, it can be hard to coordinate busy
schedules to travel and learn the method,” Dr. Giagtzoglou tells us. This was the case when he met
Dr. Greg Macleod, a JoVE author and expert in motor neuron backfilling. Dr. Giagtzoglou
discovered Dr. Macleod’s article and immediately saw the benefit of JoVE.
With over 2200 peer-reviewed video-methods articles, Dr. Giagtzoglou found demonstrations of the
techniques he needed and frequently returns to JoVE when learning new techniques or helping
colleagues. “There are at least nine JoVE articles the lab uses regularly, either for review or to learn
a new technique. It’s like night and day. JoVE’s visual demonstration, from the beginning to the
end, is helpful to researchers,” Dr. Giagtzoglou says. “Watching a JoVE video-article is so much
more helpful than reading just materials or methods, which can have grammatical mistakes,
bad syntax, or may be hard to interpret.”
Reduce the time it takes to learn a technique from weeks to days.
Reduce the number of generations of flies required to get experimental results, saving
thousands of dollars in man-hours of researchers and cost of fly upkeep.
Reduce the emotional stress of researchers waiting to get crucial results.
Using JoVE, Dr. Giagtzoglou and his colleagues were able to:
to be trained in laboratory techniques established up to 30 years ago.
Often, these techniques lack recent literature describing their steps, and scientists looking to innovate
need to go to the labs of specialist “gurus” to learn a method. Dr. Nikolaos Giagtzoglou, a
post-doctoral researcher in the Bellen lab at Baylor School of medicine, needed to learn many
techniques to conduct his own research and be a good collaborator. He has found success using
JoVE to learn these new techniques.