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HUNTINGTO

DISEVYV

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• Neurodegenerative Diorder

•

A!e"t #u"$e "oordination• Caue un"ontro$$ed #ove#ent

• %ead to #enta$ de"$ine and&e'aviora$ (#)to#

• %o o* inte$$e"tua$ *a"u$tie

•

E#otiona$ ditur&an"e• Menta$ a&i$itie de"$ine into de#entia

• Ear$iet (#)to# are u&t$e)ro&$e# +it' #ood and "ognition

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• 0a#i$ia$ dieae1 )a*ro# )arent to "'i$d

• Ea"' "'i$d 'a -2-

"'an"e o* in'eriting tgene

• I* t'e "'i$d goe not int'e dieae3 t'e( +i$$ deve$o) t'e dieae oit onto *uture generat

• Dieae #a( deve$o)ear$ier in $i*e in ea"'u""eive generation(#)to# tat )rogre*ater

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• Gene i "a$$ed Huntingtin

• Huntingin gene )rovide

in*or#ation *or t'e #a4ingo* a )rotein "a$$ed5Huntingtin6

• CAG 7"(toine3 adenine3gaunine8 re)eat e9)and+it'in t'e Huntingtin gene3

*or#ing a di!*erent )rotein

•  T'i gradua$$( "aueda#age in t'e &rain "e$$

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•  :uveni$e’ 'ave 'ig'ernu#&er o* re)eat t'anadu$t do

• Having #ore evere

(#)to#• Sti!ne o* t'e $eg

• C$u#ine o* ar# and $eg

• De"$ine in "ognitive *un"tion

• C'ange in &e'aviour

• Sei;ure 7In

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>ROGNOSIS• No "ure

• Manage#ent and treat#ent o*(#)to#

• >'(i"a$ t'era)(3 o""u)ationa$t'era)(3 )ee"' t'era)(

• %i*e e9)e"tan"( i genera$$(

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RE0ERENCES

• 'tt)1@@+++.n"&i.n$#.ni'.gov@)ued'ea$t'@>MHTMHT