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CURRICULUM VITAE Kenneth Laurence Tyler, M.D.

Education: A.B., Harvard University, Cambridge, MA

Magna Cum Laude M.D., The Johns Hopkins University School of Medicine, Baltimore, MD

Post Doctoral Training: Internship and Residencies: Intern and Resident, Internal Medicine, Peter Bent Brigham Hospital, Boston, MA Neurology Resident, Massachusetts General Hospital, Boston, MA Chief Resident, Neurology, Massachusetts General Hospital, Boston, MA Research Fellowships: Research Fellow, Microbiology and Molecular

Genetics, Harvard Medical School, Boston, MA

Licensure and Certification:

American Board of Internal Medicine American Board of Psychiatry and Neurology Colorado License Colorado State Board of Medical Examiners

Current Academic Appointments: Professor of Neurology (tenured) Professor of Medicine, Microbiology, Immunology University of Colorado Health Sciences Center Reuler-Lewin Family Professor of Neurology Current Hospital Appointments:

  2 Neurology Services, VA Medical Center University Hospital, Denver Health Medical Center Denver, CO Other Professional Positions and Appointments: Member, University of Colorado Cancer Center Graduate Faculty, Depts. Microbiology, Immunology, Univ. Colorado Health Sciences Center Faculty, Medical Scientist Training Program (MSTP) Univ. Colorado Health Sciences Center Faculty, Biomedical Sciences Program Univ. Colorado Health Sciences Center Member, Neuroscience Program and Center Univ. Colorado Health Sciences Center

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Selected Awards and Honors: Phi Beta Kappa Alpha Omega Alpha Honor Medical Society S. Weir Mitchell Award, American Academy of Neurology

Alfred P. Sloan Foundation Research Fellow 1991 Science College, Concordia University, Public Lecture Series, Montreal, Canada 1997 Rhea & Louis Boshes Visiting Professor Dept. Neurology, Northwestern University School of Medicine 1997 elected to membership, American Society for Clinical Investigation (ASCI) 1999-current Who’s Who in America® (2000 et seq.) 2000 Lawrence McHenry Jr. Award, American Academy of Neurology 2001-current Best Doctors in America, 2001-current (http://www.bestdoctors.com) 2002 5th Landau Lecturer, Washington University School of Medicine, St. Louis,

MO. 2004 Julius Brendel Trust Visiting Professor, Auckland, New Zealand 2004 Inaugural Walter Friedlander Lecturer, University of Nebraska School of

Medicine, Omaha, NE 2004 WT Connell Memorial Professor, Queens University, Ontario, Canada 2006-2008 Chair, National Institute’s of Health (NIH) Clinical Neuroimmunology &

Brain Tumors Study Section (CNBT) 2007, 2008 America’s Top Physicians, Guide to America’s Top Physicians, Consumers

Research Council of America, (http://www.consumersresearchcncl.org) 2007 Fellow, American Association for the Advancement of Science 2007 Elected to membership, Association American Physicians (AAP) Selected Recent Major National Committee Assignments and Study Sections:

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2003 NIH/NIAID Neurology Advisory Group for West Nile Virus 2003 External Reviewer, Institut Pasteur, L’Evaluation Scientifique, Paris.

France 2003 Temporary Member, Experimental Virology (EVR) Study Section, NIH 2004 Member, Special Emphasis Panel, ZRG1 (Neurovirology), Experimental

Virology (EVR) Study Section, NIH 2004-2006 Regular Member, Clinical Neuroimmunology and Brain Tumors Study

Section (CNBT, Formerly BDCN-4), Study Section, NIH. 2006-2008 Chair, NIH CNBT (Clinical Neuroimmunology & Brain Tumors) Study

Section 2007 Member, NIH Special Emphasis Panel, ZRG1 IDM-R 02 (Pathogenic

Viruses) 2008 Member, NIH Special Emphasis Panel, ZRG1 IDM-B (02) (Viral

Pathogens) 2008 Reviewer, NIH Director’s New Innovator Awards (invited) 2008 Member, NIH Special Emphasis Panel, ZAG1 ZIJ-2 (05)(Aging and

Disease) 2009 Reviewer, NIH ZRG1 IMM-E(58)R Editorial Boards: 1990-1997 Journal of the Neurological Sciences (Associate Editor) 1993-1997 Journal of the History of Neuroscience 1992-1997 Journal of Virology 2005-2007 European Journal of Neurology 1990- Microbial Pathogenesis 1995- Journal of Neurovirology (Senior Associate Editor, 2006-)

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1997- Archives of Neurology 2002- Apoptosis 2003- Experimental Neurology 2003- Neurology 2003- Journal of Infectious Disease 2004- Reviews in Neurological Disease 2005- Journal of Virology 2005- Virology 2009- Annals of Neurology 2009- Journal of Cell Death Selected Memberships, Offices and Committee Assignments in Professional Societies: 1979 (Member)- American College of Physicians (ACP) 1990 Fellow 1980- American Federation for Medical Research (AFMR) 1981 (Member)- American Academy of Neurology (AAN) 1987 Fellow Annual Meeting Scientific Program Chair or Co-Chair: Neurochemistry (1985), Neurovirology (1986-7,

1989, 1991, 1993), History of Neurology (l990-95, 2001, 2002), Infection & AIDS (1996, 1997, 2000), CNS Infections (1999), NeuroAIDS (1999), Infections/AIDS/Prions (2004-6), Topic Chair: Infections/AIDS/Prions 2005-8

History Section: Secretary 1987-89; President 1989-91, Executive Committee 1996-99

Member, Scientific Issues/Program Committee, 1989-1997 Member, Scientific Program Subcommittee 2005-2008 Chair, McHenry Award Subcommittee, 1989-1994

Member, Awards Policy Task Force, 1993-1997 Member, Foundation Research Award Subcommittee, 1994-98; Chair, 1999-2001 Chair, Membership Committee, 2001-2005 Councilor, Neuro-Infectious Disease Section, 2003-2005, 2006- Member, Leadership Task Force 2005-6

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Director, (AAN Board of Directors) 2003-2007 1984- American Society for Microbiology (ASM) 1984-1991 Boston Society of Psychiatry and Neurology 1985- American Society for Virology (ASV) Symposium Speaker, 11th Annual Meeting (1992)

Convenor, 13th Annual Meeting (1994), Viral Immunology Workshop Convenor, 17th Annual Meeting (1998), Viral Pathogenesis Workshop

Convenor, 21st Annual Meeting) (2002). Viral Pathogenesis Workshop Program Committee (2004-2006)

1991- Society for Neuroscience; Neurobiology of Disease Workshop Organizing Committee (1991) Committee on the History of Neuroscience (1993-) 1991- American Neurological Association (ANA) Scientific Program Committee (2006-2009) Long Range Planning Committee (1999-2000)(2004-2005) History of the Association Committee (2001-2002) 1992- Colorado Society of Clinical Neurologists Secretary Treasurer, 1993-1995 1992- Association of VA Neurologists Councilor, 1996-1998 1997- American Society for Clinical Investigation 2000- International Society for Neurovirology 2003- Infectious Disease Society of America (IDSA) Fellow 2007- Fellow, American Association for the Advancement of Science (AAAS) 2007- Association of American Physicians (AAP)

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Selected Recent Outside Invited Lectures, Grand Rounds, Seminars, Symposia: . 2003 Seminar Speaker, Department of Microbiology & Molecular Genetics,

Harvard Medical School, Boston, MA. 2003 “C. Miller Fisher Rounds” and Neuroscience Seminar, Partners Neurology

Program (Brigham and MGH), Boston, MA. 2003 Invited Speaker, Annual Meeting, NIH/NIAID Collaborative Antiviral

Study Group, Bethesda, MD. Challenges in the diagnosis and management of adult herpes simplex virus encephalitis.

2003 10th Annual Meeting, International Herpesvirus Management Forum, Paris,

France (invited speaker). Herpes simplex virus meningitis. 2003 Seminar Speaker, Departement de Virologie, Institut Pasteur, Paris, France 2003 Guest Lecturer, Institut Paul Broca (INSERM) and Departement de

Neurologie, Hopital de St. Anne, Paris, France 2003 Plenary Discussant, West Nile Virus, 55th Annual Meeting, American

Academy of Neurology, Honolulu, Hawaii 2003 Plenary Speaker, 5th Meeting, International Society of Neurovirology,

Baltimore, MD. 2004 Plenary Speaker and Co-Chair Session on Epidemiology/Clinical Studies Center for Disease Control (CDC), 5th National Conference on West Nile

Virus in the United States, Denver, CO 2004 Speaker, Keystone Symposium on the Pathogen and Host Standoff:

Persistent and Latent Infection. Taos, New Mexico 2004 Seminar Speaker, Cancer Biology Research Group, University of Calgary,

Calgary, Canada 2004 Grand Rounds, Department of Clinical Neurosciences, University of

Calgary, Calgary, Canada 2004 Inaugural Walter Friedlander Lecturer, University of Nebraska School of

Medicine Omaha, NE 2004 24th WT Connell Memorial Lecture, Queens University, School of

Medicine, Kingston, Ontario, Canada (West Nile encephalomyelitis) 2004 John Austin Society Lecture, Queens University, School of Medicine,

Kingston, Ontario, Canada (Development of ideas on cerebral localization)

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2004 Seminar Speaker, Department of Microbiology & Immunology, Queen’s University, Kingston, Ontario, Canada (Reovirus-induced apoptosis)

2004 Neurology Grand Rounds, University of Chicago Pritzker School of

Medicine 2004 Neurology Grand Rounds, Brigham & Women’s /Beth Israel-Deaconess

Hospitals, Harvard Medical School, Boston, MA 2005 Neurology Grand Rounds, NYU School of Medicine, NY, NY 2005 Neurology Grand Rounds, Cornell University School of Medicine, NY, NY 2005 Seminar Speaker. Pathogenesis Affinity Group, The Scripps Research

Institute, La Jolla, CA (How a virus kills a cell). 2005 New York Academy of Sciences. Neuroimmunology Discussion Group

Meeting. 2006 Neurology Grand Rounds, Department of Neurology, Albert Einstein

University School of Medicine, NY, NY. 2006 Neurology Grand Rounds, Department of Neurology, Columbia University

School of Medicine, NY, NY. 2006 Neurology Grand Rounds, Department of Neurology & Neuroscience,

University of California at San Diego 2006 Neurology Grand Rounds, Neurolgische Klinik und Poliklinik,

Universitatsklinikum Wurzburg, Germany 2006 Seminar, Departement de Biologie Cellulaire et Morphologie (DBCM) and

the Departement de Physiologie, Universite de Lausanne, Switzerland 2007 Neurology Grand Rounds, New York University, NYC 2007 National Diabetes Trial Network (Diabetes TrialNet) Steering Committee 2007 40th Annual Winter Conference on Brain Research, Snowmass Village, CO 2007 B-Cell Summit: Targeting B Cells in the Treatment of Immune-Mediated

Disease, Newport Beach, CA (Genentech/Biogen Idec) 2007 Neurology Grand Rounds, Massachusetts General Hospital, Harvard

Medical School. 2007 Speaker, Presidential Plenary Symposium, American Neurological

Association 132nd Annual Meeting, Washington DC

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2008 University of Illinois College of Medicine at Peoria. Seminar. Department of Cancer Biology and Pharmacology.

2008 Chair, Symposium on Reo, rota, and orbiviruses. XIVth International

Congress of Virology, Istanbul, Turkey, Aug 10-15, 2008 2008 Speaker, Infectious diseases of the nervous system: pathogenesis and

worldwide impact (conference), Pasteur Institute, Paris 2008 Neurology Grand Rounds, Yale University School of Medicine 2009 Symposium, Genentech, Immunology, Tissue Growth & Repair (ITGR)

Group, San Francisco, CA 2009 Neurology Grand Rounds, University of Pittsburgh School of Medicine 2009 Special Lecturer & Workshop Chair (Signal Transduction & Cellular/viral

Gene Expression), 9th International Symposium on Neurovirology, Miami Beach, FL

2009 Neurology Grand Rounds, Weil Medical College, Cornell University 2009 Speaker, 6th Hong Kong University Pasteur Institute -Virology Course,

Hong Kong University-Pasteur Research Center, Hong Kong, China 2009 Keynote Speaker, 27th Annual Conference on Pediatric Infectious Diseases,

Vail, CO Selected Recent Graduate and Post-graduate Courses: 2003 Chair, Course on Neurovirology, 55th Annual Meeting American Academy

of Neurology, Honolulu, Hawaii 2004 Faculty, Course on Infections in the Nervous System (Viral encephalitis) 56th Annual Meeting American Academy of Neurology, San Francisco, CA 2005 Co-Director, Course on the Neurological Complications of Emerging

Infections and Bioterrorism (with J. Berger), 57th Annual Meeting American Academy of Neurology, Miami Beach, FL

2006 Faculty, Course on Infections of the Nervous System (Viral encephalitis) 58th Annual Meeting American Academy of Neurology, San Diego, CA. 2006 Faculty, Course on Neurological Complications of Emerging Infections and

Bioterrorism, 58th Annual Meeting American Academy of Neurology, San Diego, CA.

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2006 Faculty, Teaching Course on Current Treatments in Neurology (Herpes virus infection of the nervous system), 16th Meeting of the European Neurological Society, Lausanne Switzerland

2006 Chair, Symposium on Novel Neurotherapeutic Approaches to Neurological

Diseases. American Neurological Association (ANA) 131st Annual Meeting, Chicago, IL

2006 Co-Director, Workshop on MS, JC Virus and PML. American

Neurological Association (ANA) 131st Annual Meeting, Chicago, IL 2007 Faculty, Neurological Complications of Emerging Infections and

Bioterrorism, 59th Annual Meeting, American Academy of Neurology, Boston, MA

2007 Chair, Derek Denny Brown Symposium, American Neurological

Association (ANA) 132nd Annual Meeting, Washington, DC 2008 Faculty, Course on Infections in the Nervous System 60th Annual Meeting American Academy of Neurology, Chicago, IL 2009 Faculty, 6th Hong Kong University-Pasteur Research Centre Virology

Course, Hong Kong, China (July 7-24, 2009) 2009 Faculty, 27th Annual Conference on Pediatric Infectious Diseases, Vail, CO

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Bibliography: I. Original Articles 1. Tyler KL, Poletti CE, Heros RC. Cerebral amyloid angiopathy with multiple

intracerebral hemorrhages. J Neurosurg 57:286-289, 1982. 2. Tyler KL, Alder D. Twenty-eight years of benign recurring Mollaret's meningitis. Arch

Neurol 40:42-43, 1983. 3. Tyler KL. Diagnosis and management of acute viral encephalitis. Semin Neurol

4:480-489, 1984. 4. Tyler KL, Tyler HR. Answers to questions on stroke. Hospital Medicine. 19:206-228,

July 1983 (Part I); 19:89-104, August 1983 (Part II). 5. Tyler KL, Tyler HR. Differentiating organic dementia. Geriatrics. 39:38-52, 1984. 6. Tyler KL, Bronson RT, Byers KB, Fields BN. The molecular basis of viral neurotropism:

experimental reovirus infection. Neurology 35:88-92, 1985. 7. Tyler KL, Gross RA, Cascino GD. Unusual viral causes of transverse myelitis: hepatitis

A virus and cytomegalovirus. Neurology 36:855-858, 1986. 8. Kaye KM, Spriggs DR, Bassel-Duby R, Fields BN, Tyler KL. Genetic basis for altered

pathogenesis of an immune-selected antigenic variant of reovirus type 3 (Dearing). J Virol 59:90-97, 1986. [PMC253042]

9. Tyler KL, McPhee DA, Fields BN. Distinct pathways of viral spread in the host

determined by reovirus S1 gene segment. Science 233:770-774, 1986. 10. Bassel-Duby R, Spriggs DR, Tyler KL, Fields BN. Identification of attenuating

mutations on the reovirus type 3 S1 double-stranded RNA segment with use of a rapid sequencing technique. J Virol 60:64-67, 1986. [PMC253902]

11. Gonzalez-Scarano F, Tyler KL. Molecular pathogenesis of neurotropic viral infections.

Ann Neurol 22:565-574, 1987. 12. Tyler KL. Host and viral factors which influence viral neurotropism. I. Cell receptors and viral cell attachment proteins. Trends Neurosci 10:455-460, 1987. 13. Tyler KL. Host and viral factors which influence viral neurotropism. II. Viral genes, host

genes, site of entry and route of spread of virus. Trends Neurosci 10:492-497, 1987. 14. Tyler KL, McPhee DA. Molecular and genetic aspects of the pathogenesis of viral

infections of the central nervous system. Crit Rev Neurobiol 3:221-243, 1987. 15. Tyler KL, Davis KR, Hedley-Whyte T. Case records of the Massachusetts General

Hospital. Weekly clinicopathological exercises. Case 45-1988. A 67-year old woman with

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chronic lymphocytic leukemia, homonymous hemianopia, confusion, and poor balance (Progressive Multifocal Leucoencephalopathy). N Engl J Med 319:1268-1280, 1988.

16. Virgin HW IVth, Bassel-Duby R, Fields BN, Tyler KL. Antibody protects against lethal

infection with the neurally spreading reovirus type 3 (Dearing). J Virol 62:4594-4604, 1988. [PMC253571]

17. Lipkin I, Tyler KL, Waksman BH. Viruses, the immune system and central nervous

system diseases. Trends Neurosci 11:43-45, 1988.

18. Leib DA, Coen DM, Bogard CL, Hicks KA, Yager DR, Knipe DM, Tyler KL, Schaffer PA. Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency. J Virol 63:759-768, 1989. [PMC247748]

19. Coen DM, Kosz-Vnenchak M, Jacobson JG, Leib DA, Bogard CL, Schaffer PA, Tyler

KL, Knipe DM. Thymidine kinase negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia, but do not reactivate. Proc Natl Acad Sci U.S.A 86:4736-4740, 1989. [PMC287348]

20. Tyler KL, Virgin HW IVth, Bassel-Duby R, Fields BN. Antibody inhibits defined stages

in the pathogenesis of reovirus serotype 3 infection of the central nervous system. J Exp Med 170:887-900, 1989.

21. Sacks SL, Wanklin RJ, Reece DE, Hicks KA, Tyler KL, Coen DM. Progressive

esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity? Ann Intern Med 111:893-899, 1989.

22. Tyler KL. Pathogenesis of Reovirus infections of the central nervous system. Semin

Neurosci 3:117-124, 1991. 23. Virgin HW IVth, Tyler KL. The role of immune cells in protection against and control of

reovirus infection in neonatal mice. J Virol 65:5157-5164, 1991. [PMC248992] 24. Virgin HW IVth, Mann MA, Fields BN, Tyler KL. Monoclonal antibodies to reovirus

reveal structure/function relationships between capsid proteins and genetics of susceptibility to antibody action. J Virol 65:6772- 6781, 1991. [PMC250764]

25. Ravilochan K, Tyler KL. Human transmissible neurodegenerative diseases (prion diseases). Semin Neurol 12:178-192, 1992. 26. Tyler KL, Mann MA, Fields BN, Virgin HW IVth. Protective anti-reovirus monoclonal

antibodies and their effects on viral pathogenesis. J Virol 67:3446-3453, 1993. [PMC237690]

27. Sherry B, Li X-L, Tyler KL, Cullen JM, Virgin HW IVth. Lymphocytes protect against,

and are not required for, reovirus-induced myocarditis. J Virol 67: 6119-6124, 1993. [PMC238034]

28. Watson CPN, Tyler KL, Bickers DR, Millikan LE, Smith S, Coleman E.

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A randomized vehicle-controlled trial of topical capsaicin in the treatment of postherpetic neuralgia. Clin Ther 15:510-526,1993.

29. Tedder DG, Ashley R, Tyler KL, Levin MJ. Herpes Simplex virus infection as a cause of

benign recurrent lymphocytic meningitis. Ann Intern Med 121:334-338,1994. 30. Virgin HW IVth, Mann MA, Tyler KL. Protective antibodies inhibit reovirus

internalization and uncoating by intracellular proteases. J. Virol 68:6719-6729, 1994. [PMC237093]

31. Tyler KL, Sandberg E, Baum KF. Medial medullary syndrome and meningovascular

syphilis: A case report in an HIV-infected man, and review of the literature. Neurology 44: 2231-2235,1994.

32. Tyler KL. Polymerase chain reaction and the diagnosis of viral CNS diseases. Ann Neurol

36: 809-811, 1994. 33. Paskavitz JF, Anderson CA, Filley CM, Kleinschmidt-Demasters BK, Tyler KL. Acute

arcuate fiber demyelinating encephalopathy following Epstein-Barr virus infection. Ann Neurol 38: 127-131, 1995.

34. Dermody TS, Chappell JD, Hofler JG, Kramp W, Tyler KL. Eradication of persistent

reovirus infection from a B-cell hybridoma. Virology 212:272-276, 1995. 35. Tyler KL, Squier MKT, Rodgers SE, Schneider BE, Oberhaus SM, Grdina TA, Cohen

JJ, Dermody TS. Differences in the capacity of reovirus strains to induce apoptosis are determined by the viral attachment protein σ1. J Virol 69:6972-6979, 1995. [PMC189616]

36. Tyler KL, Tedder DG, Yamamoto LJ, Klapper JA, Ashley R, Lichtenstein KA, Levin MJ.

Recurrent brainstem encephalitis associated with herpes simplex virus type 1 DNA in cerebrospinal fluid. Neurology 45: 2246-2250, 1995.

37. Almond JW, Brown P, Gore SM, Hofman A, Wientjens PW, Ridley RM, Baker HF,

Roberts GW, Tyler KL. Creutzfeldt-Jakob disease and bovine spongiform encephalopathy: any connection? BMJ (British Medical Journal) 311:1415-1421, 1995.

{Tyler KL. Risk of human exposure to bovine spongiform encephalopathy. BMJ (British

Medical Journal) 311: 1420-1421, 1995.] 38. Tyler KL, Squier MKT, Brown AL, Pike B, Willis D, Oberhaus SM, Dermody TS,

Cohen JJ. Linkage between reovirus-induced apoptosis and inhibition of cellular DNA synthesis: Role of the S1 and M2 genes. J Virol 70:7984-7991, 1996. [PMC190871]

39. Rodgers SE, Barton ES, Oberhaus SM, Pike B, Gibson CA, Tyler KL, Dermody TS.

Reovirus-induced apoptosis of MDCK cells is not linked to viral yield and is blocked by bcl-2. J Virol 71: 2540-2546,1997. [PMC191370]

40. Oberhaus SM, Smith RL, Clayton GH, Dermody TS, Tyler KL. Reovirus infection and

tissue injury in the mouse central nervous system are associated with apoptosis. J Virol

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71:2100-2106,1997. [PMC191302] 41. Oberhaus SM, Dermody TS, Tyler KL. Apoptosis and the cytopathic effects of reovirus.

Curr Top Microbiol.Immunol 233/2:23-49, 1998. 42. Tyler KL. Pathogenesis of reovirus infections of the central nervous system. Curr Top

Microbiol Immunol 233/2:93-124, 1998. 43. Virgin HW IVth, Dermody TS, Tyler KL. Cellular and humoral immunity to reovirus

infection. Curr Top Microbiol Immunol 233/2:147-161, 1998. 44. Tyler KL, Sokol RJ, Oberhaus SM, Mysan L, Murphy JR, Low R, Brown WR. Detection

of reovirus RNA in hepatobiliary tissues from patients with extrahepatic bile duct atresia and choledochal cysts. Hepatology 27:1475-1482, 1998.

45. Fodor PA, Levin MJ, Weinberg A, Sandberg E, Sylman J, Tyler KL. Atypical herpes

simplex virus encephalitis diagnosed by PCR amplification of viral DNA from CSF. Neurology 51:554-559,1998.

46. Kleinschmidt-DeMasters BK, Mahalingham R, Shimek C, Tyler KL, Gilden DH.

Profound CSF pleocytosis and Froin’s syndrome secondary to widespread necrotizing vasculitis in varicella-zoster encephalomyelitis. J Neurol Sci 159:213-218, 1998.

47. Pelosi E, Rozenberg F, Coen DM, Tyler KL. A Herpes Simplex virus DNA

polymerase mutant that specifically attenuates neurovirulence in mice. Virology 252:364-372, 1998. 48. DeBiasi RL, Squier MKT, Pike B, Wynes M, Dermody TS, Cohen JJ, Tyler KL. Reovirus-

induced apoptosis is preceded by increased cellular calpain activity and is blocked by calpain inhibitors. J. Virol. 73:695-701, 1999. [PMC103876]

49. Clifford DB, Yiannoutsos C, Glicksman M, Simpson DM, Singer EJ, Piliero PJ, Marra

CM, Francis GS, McArthur JC, Tyler KL, Tselis AC, Hyslop NE. HAART improves prognosis in HIV-associated progressive multifocal leukoencephalopathy. Neurology 52:623-625,1999.

50. DeBiasi RL, Tyler KL. Polymerase chain reaction in the diagnosis and management of

nervous system infections. Arch Neurol 56:1215-1219, 1999. 51. Anderson CA, Sandberg E, Filley CM, Harris SL, Tyler KL. One and one-half syndrome

with supranuclear facial weakness. Magnetic resonance imaging localization. Arch Neurol 56:1509-1511,1999.

52. Connolly JL, Rodgers SE, Clarke P, Ballard DW, Kerr LD, Tyler KL, Dermody TS.

Reovirus-induced apoptosis requires activation of transcription factor NF-κB J Virol 74:2981-2989, 2000. [PMC111796]

53. Yijuri T, Ware M, Widmann C, Oyer R, Russell D, Chan E, Zaitsu Y, Clarke P, Tyler KL,

Oka Y, Fanger GR, Henson P, Johnson GL.MEK kinase 1 gene disruption alters cell

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migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-κB activation. Proc Natl Acad Sci U.S.A 97:7272-7277, 2000. [PMC16535]

54. Clarke P, Meintzer SM, Gibson S, Widmann C, Garrington TP, Johnson GL, Tyler KL.

Reovirus-induced apoptosis is mediated by TRAIL. J Virol 74: 8135-8139, 2000. [PMC112347]

55. Poggioli GJ, Keefer C, Connolly JL, Dermody TS, Tyler KL. Reovirus-induced G2/M

arrest requires σ1s and occurs in the absence of apoptosis. J Virol 74:9562-9570, 2000. [PMC112387]

56. DeBiasi R, Edelstein C, Sherry B, Tyler KL. Calpain inhibition protects against virus-

induced apoptotic myocardial injury J Virol 75:351-361, 2001. [PMC113928] 57. Tyler KL, Clarke P, DeBiasi RL, Kominsky D, Poggioli G. Reovirus and the host cell..

Trends Microbiol 9:560-564, 2001. 58. Poggioli GJ, Dermody TS, Tyler KL. Reovirus-induced σ1s-dependent G2/M cell cycle

arrest is associated with inhibition of p34cdc2. J Virol 75:7429-7434, 2001. [PMC114978] 59. DeMasters BK, DeBiasi R, Tyler KL. Polymerase chain reaction as a diagnostic adjunct in

herpesvirus infections of the nervous system. Brain Pathol.11:452-464, 2001. 60. Clarke P, Meintzer SM, Widmann C, Johnson GL, Tyler KL. Reovirus infection activates JNK-dependent transcription factor c-Jun. J Virol 75:11275-11283, 2001. [PMC114712] 61. Clarke P, Meintzer SM, Spalding AC, Johnson GL, Tyler KL. Caspase-8 dependent sensitization of cancer cells to TRAIL-induced apoptosis following reovirus infection. Oncogene 20:6910-6919, 2001. 62. Spalding AC, Jotte RM, Scheinman RI, Geraci MW, Clarke P, Tyler KL, Johnson GL. TRAIL and inhibitors of apoptosis are opposing determinants for NFκB-dependent, genotoxin-induced apoptosis of cancer cells. Oncogene 21:260-271, 2002. 63.  Poggioli GJ, DeBiasi RL, Bickel, R., Bickel R, Jotte R, Spalding A, Johnson GL, Tyler

KL. Reovirus-induced alterations in gene expression related to cell cycle regulation. J Virol 76:2585-2594, 2002. [PMC135961]

64. Redington JJ, Tyler KL. Viral infections of the nervous system 2002. Update on diagnosis

and treatment. Arch Neurol 59:712-718, 2002. 65. DeBiasi RL, Kleinschmidt-DeMasters BK, Weinberg A, Tyler KL. Use of PCR for the

diagnosis of herpesvirus infections of the central nervous system. J Clin Virol 25 (suppl):5-11, 2002.

66. Kominsky D, Bickel RJ, Tyler KL. Reovirus induced apoptosis requires both death-

receptor- and mitochondrial-mediated caspase-dependent pathways of cell death. Cell Death and Differentiation 9:926-933, 2002.

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67. Richardson-Burns S, Tyler KL. Reovirus induced neuronal apoptosis is mediated by

caspase 3 and is associated with the activation of death receptors. J Neurovirol 8:365-380, 2002.

68. Weinberg A, Li S, Palmer M, Tyler KL. Quantitative CSF PCR in Epstein-Barr virus

infections of the central nervous system. Ann Neurol 52:543-548, 2002. 69. Kominsky DJ, Bickel R, Tyler KL. Reovirus-induced apoptosis requires mitochondrial

release of Smac/DIABLO and involves reduction of cellular inhibitor of apoptosis protein levels. J Virol 76:11414-11424, 2002. [PMC136770]

70. DeBiasi RL, Kleinschmidt-DeMasters BK, Richardson-Burns S, Tyler KL. Herpes

simplex virus and cytomegalovirus encephalitis in humans are associated with CNS apoptosis. J Infect Dis 186:1547-1557, 2002.

71. Richardson-Burns S, DeBiasi R, Kleinschmidt-DeMasters BK, Tyler KL. Progressive

multifocal leukoencephalopathy is associated with apoptosis of infected oligodendrocytes in the CNS of AIDS and non-AIDS patients. Arch Neurol 59:1930-1936, 2002.

72. Mann MA, Tyler KL, Knipe DM, Fields BN. Type 3 reovirus neuroinvasion after

intramuscular inoculation: Viral genetic determinants of lethality and spinal cord infection. Virology 303:213-221, 2002.

73. Clarke P, Tyler KL. Reovirus-induced apoptosis: A minireview. Apoptosis 8:141-150,

2003. 74. Clarke P, Meintzer S, Moffitt L, Tyler KL. Two distinct phases of virus-induced NF-κB

regulation enhance TRAIL-mediated apoptosis in virus-infected cells. J Biol Chem 278:18092-18100, 2003.

75. Gonzales N, Tyler KL, Gilden DH. Recurrent dermatomal vesicular skin lesions. A clue to

diagnosis of herpes simplex virus 2 meningitis. Arch. Neurol. 60:868-869, 2003. 76. DeBiasi RL, Clarke P, Meintzer S, Jotte R, Kleinschmidt-DeMasters BK, Johnson GL,

Tyler KL. Reovirus-induced alteration in expression of apoptosis and DNA repair genes with potential roles in viral pathogenesis. J Virol 77: 8934-8947, 2003. [PMC167209]

77. Cuevas BD, Abell AN, Witowsky JA, Yujiri T, Johnson NL, Kesavan K, Ware M, Jones

PL, Weed SA, DeBiasi RL, Oka Y, Tyler KL, Johnson GL. MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts. EMBO J 22:3346-3355, 2003. [PMC165646]

78. McCabe K, Tyler KL, Tanabe J. Diffusion-weighted MRI abnormalities: a clue to the

diagnosis of herpes simplex encephalitis. Neurology 61:1015-1016, 2003. 79. Edelmann KH, Richardson-Burns S, Alexopoulou L, Tyler KL, Flavell RA, Oldstone

MBA. Does Toll-like receptor 3 play a biological role in virus infections? Virology 322:231-8, 2004.

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80. Richardson-Burns SM, Tyler KL. Regional differences in viral growth and CNS injury

correlate with apoptosis. J Virology 78:5466-75, 2004. [PMC400348] 81. Tyler KL, Barton ES, Ibach ML, Robinson C, Campbell JA, O’Donnell SM, Valyi-Nagy

T, Clarke P, Wetzel JD, Dermody TS. Isolation and characterization of a novel type 3 reovirus from a child with meningitis. J Infect Dis 189:1664-75, 2004.

82. Hoyt C, Bouchard R, Tyler KL. Novel nuclear herniations induced by nuclear localization

of a viral protein. J Virology 78:6360-6369, 2004. [PMC416550] 83. Tyler KL, West Nile virus in the United States. Arch Neurol 61:1190-1195, 2004. 84. Kleinschmidt-DeMasters BK, Marder B, Levi M, Laird SP, McNutt T. Escott E, Everson

GT, Tyler KL. Naturally-acquired West Nile virus encephalomyelitis in transplant recipients: Clinical, laboratory, diagnostic and neuropathological features. Arch Neurol 61:1210-1220, 2004.

85. Tyler, KL. Herpes simplex virus infections of the central nervous system: Encephalitis and

meningitis, including Mollaret’s. Herpes 11 (suppl 2):57A-64A, 2004. 86. DeBiasi RL, Tyler KL. Molecular methods for diagnosis of viral encephalitis. Clinical

Microbiol Rev. 17:903-925, 2004. [PMC523566] 87. DeBiasi RL, Robinson BA, Sherry B, Bouchard R, Brown RD, Rizeq M, Long C, Tyler

KL. Caspase inhibition protects against reovirus-induced myocardial injury in vitro and in vivo. J. Virol. 78:11040-11050, 2004. [PMC521817]

88. Clarke P, Meintzer SM, Wang Y, Moffitt LA, Richardson-Burns SM, Johnson GL, Tyler

KL. JNK regulates the release of pro-apoptotic mitochondrial factors in reovirus-infected cells. J. Virology 78:13132-13138, 2004. [PMC524973]

89. Tyler KL. Infectious Diseases: West Nile virus. Rev. Neurol. Dis. 1:49-51, 2004. 90. Tyler KL. West Nile virus infection. Rev. Neurol. Dis. 1:83-90, 2004. 91. Tyler KL. Update on herpes simplex encephalitis. Rev. Neurol. Dis. 1:169-178, 2004. 92. Weinberg A, Bloch KC, Li S, Tang Y-W, Palmer M, Tyler KL. Dual infections of the

central nervous system with Epstein-Barr virus. J. Infect. Dis. 191:234-237, 2005. 93. Hoyt C, Richardson-Burns S, Goody R, Tyler KL. Reovirus non-structural protein σ1s is

a determinant of virulence in the heart and CNS. J. Virol. 79:2743-2753, 2005. [PMC548430]

94. Beckham JD, Tyler KL. Progressive multifocal leukoencephalopathy following

natalizumab therapy. Rev.Neurol. Dis. 2:158-163, 2005. 95. Tyler KL, Khalili K. Natalizumab and progressive multifocal leukoencephalopathy.. Rev.

  18

Neurol. Dis. 2:144-149, 2005. 96. Richardson-Burns, SM, Tyler KL. Minocycline delays disease onset and mortality in a

murine model of viral encephalitis. Exp. Neurol. 192:331-339, 2005. [PMC2362387] 97. Clarke P, Richardson-Burns SM, DeBiasi RL, Tyler KL. Mechanisms of apoptosis during

reovirus infection. Curr. Topics Microbiol. Immunol. 289: 1-24, 2005. [PMC2367090] 98. Clarke P, DeBiasi RL, Goody R, Hoyt CC, Richardson-Burns S, Tyler KL. Mechanisms of

reovirus-induced cell death and tissue injury: Role of apoptosis and virus-induced perturbation of host-cell signaling and transcription factor activation. Viral Immunol. 18:89-116, 2005. [PMC2366905]

99. Clarke P, DeBiasi RL, Meintzer SM, Robinson BA, Tyler KL. Inhibition of NF-κB

activity and cFLIP expression contribute to viral-induced apoptosis. Apoptosis 10:513-524, 2005.

100. Le SS, Loucks A, Udo H, Richardson-Burns S, Phelps RA, Bouchard RJ, Barth H, Aktories

K, Tyler KL, Kandel ER, Heidenreich KA, Linseman DA. Inhibition of Rac GTPase triggers a c-Jun and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons. J. Neurochem. 94:1025-39, 2005. [PMC2366110]

101. DeMasters BK, Tyler KL. Progressive multifocal leukoencephalopathy complicating

treatment with natalizumab and interferon-β-1a for multiple sclerosis. N. Engl. J. Med. 353:369-374, 2005.

102. Goody RJ, Hoyt CC, Tyler KL. Reovirus infection of the CNS enhances iNOS expression

in areas of virus-induced injury. Exp. Neurol. 195:379-90, 2005. [PMC2367058] 103. Lapadat R, DeBiasi RL, Johnson GL, Tyler KL. Genes induced by reovirus infection have

a distinct modular cis-regulatory arrangement. Current Genomics 6:501-514, 2005. 104. Tyler KL, Pape J, Goody RJ, Corkill M, Kleinschmidt-DeMasters BK. CSF in 250 patients

with serologically confirmed West Nile virus meningitis and encephalitis. Neurology 66:361-365, 2006.

105. Debiasi RL, Tyler KL. West Nile virus meningoencephalitis. Nature Clin. Pract. Neurol. 2:

264-275, 2006. 106. Beckham JD, Tyler KL. Initial management of acute bacterial meningitis in adults:

Summary of IDSA guidelines. Rev. Neurol. Dis. 3:57-60, 2006. 107. Davis LE, DeBiasi RL, Goade DE, Haaland KY, Harrington JA, Harnar JB, Pergam SA,

King MK, DeMasters, B.K., Tyler KL. West Nile virus neuroinvasive disease. Annals Neurol. 60:286-300, 2006.

108. Clarke P, Tyler KL. Down-regulation of cFLIP following reovirus infection sensitizes

human ovarian cancer cells to TRAIL-induced apoptosis. Apoptosis 12:211-223, 2007. [PMC2365758]

  19

109. Gilden DH, Mahalingam R, Cohrs RJ, Tyler KL. Herpesvirus infections of the nervous

system. Nature Clin. Pract. Neurology 3:82-94, 2007. 110. Tyler KL, Aksamit AJ, Keegan BM, Parisi JE. An 85-year-old man with chronic

lymphocytic leukemia and altered mental status. Neurology 68:460-7, 2007. 111. Anderson CA, Bosque P, Filley CM, Arciniegas DB, Kleinschmidt-DeMasters BK, Pape

JW, Tyler KL. Colorado surveillance program for chronic wasting disease transmission to humans: lessons from two highly suspicious but negative cases. Arch. Neurol. 64:439-441, 2007.

112. Beckham JD, Goody RJ, Clarke P, Bonny C, Tyler KL. Novel strategy for the treatment of

viral central nervous system infection by using a cell-permeable inhibitor of c-Jun N-terminal kinase. J. Virol. 81:6984-6992, 2007.   [PMC1933289]

113. Goody R, Rutsova K, Beckham, D, Tyler KL. J. Neurovirol. JAK-STAT signaling

pathways are activated in the brain following reovirus infection. J. Neurovirol. 13:373-383, 2007. [PMC2367059]

114. Zimmerman AK, Loucks FA, Schroeder EK, Bouchard RJ, Tyler KL, Linseman DA.

Glutathione binding to the BCL-2 homology-3 domain groove: A molecular basis for BCL-2 antioxidant function at mitochondria. J. Biol. Chem. 282:29296-29304, 2007 [PMC 45019]

115. Beckham JD, Tyler KL. Infectious disease-Developments in the field of Creutzfeldt-Jakob

disease. Rev. Neurol Dis. 4: 168-172, 2007. [PMC2613287] 116. Hudson LA, Rollins YD, Anderson CA, Johnston-Brooks C, Tyler KL, Filley CM.

Reduplicative paramnesia in Morvan’s syndrome. J. Neurol. Sci.267:154-157, 2008. 117. Tyler KL, Beckham JD. Management of acute shingles (herpes zoster). Rev. Neurol. Dis. 4: 203-208, 2007. 118. Hall DA, Tyler KL, Frey KL, Kozora E, Arciniegas DB. Persistent neurobehavioral signs

and symptoms following West Nile Fever. J. Neuropsychiatry & Clin. Neurosci. 20:122-123, 2008.

119. Goody RJ, Schittone SA, Tyler KL. Experimental reovirus-induced acute flaccid paralysis

and spinal motor neuron cell death. J. Neuropathol. Exp. Neurol. 67:231-239, 2008. [PMC2365907]

120. Tyler KL. Acute pyogenic discitis (spondylodiscitis) in adults. Rev. Neurol. Dis. 5:8-13,

2008. 121. Davis LE, Beckham JD, Tyler KL. North American encephalitic arboviruses. Neurol. Clin.

26 :727-757, 2008. 122. Tyler KL. Genes determining susceptibility to human herpes simplex virus encephalitis.

  20

Rev. Neurol. Dis. 5: 206-8, 2008. 123. Tyler KL. Neurological infections: Advances in therapy, outcome and prediction. Lancet

Neurol. 8:19-21, 2009.

124. Clarke P, Tyler KL. Apoptosis in animal models of virus-induced disease. Nature Rev. Microbiol. 7:144-55, 2009.

125. Tyler KL. Prednisolone-but not antiviral drugs-improves outcome in patients with Bell’s

palsy. Nature Clin Prac Neurology 5:74-5, 2009. 126. Beckham JD, Tuttle K, Tyler KL. Reovirus activates TGF-β and BMP signaling pathways

in the CNS which contribute to neuronal survival following infection . J. Virol. 83:5035-45, 2009.

127. Boster A, Hreha S, Berger JR, Bao F, Penmesta R, Tselis A, Endress C, Zak I, Perumal J, Caon C, Vazquez J, Tyler KL, Racke MK, Mills S, Khan O. Progressive multifocal leukoencephalopathy and relapsing-remitting multiple sclerosis: a comparative study. Arch. Neurol. 66:593-599, 2009.

128. Clarke P, Hoyt C, Beckham JD, Tyler KL. Fas-mediated apoptotic signaling in the mouse

brain following reovirus infection. J. Virol. 83:6165-6170, 2009. 129. Miyamoto SD, Brown RD, Robinson BA, Tyler KL, Long CS, DeBiasi RL. Cardiac cell-

specific apoptotic and cytokine responses to reovirus Infection: Determinants of myocarditic phenotype. J Card Fail 15:529-39, 2009.

130. Levi ME, Quan D, Ho JT, Kleinschmidt-DeMasters BK, Tyler KL, Grazia TJ. Impact of

rituximab-associated B cell defects on West Nile virus meningoencephalitis in solid organ transplant recipients. Clin Transplantation (Epub ahead of print Aug 3. PMID:19659514), 2009.

131. Korman BD, Tyler KL, Korman NJ. Progressive multifocal leukoencephalopathy,

efalizumab, and immunosuppression: a cautionary tale for dermatologists. Arch. Derm. 145:937-42, 2009.

132. Tyler KL. Emerging viral infections of the central nervous system: Part 1. Arch. Neurol.

66:939-48, 2009. 133. Tyler KL. Emerging viral infections of the central nervous system. Part II. Arch. Neurol.

66:1065-74, 2009. 134. Blakely P, Kleinschmidt-DeMasters BK, Tyler KL, Irani D. Disrupted glutamate

transporter expression in the spinal cord with acute flaccid paralyis due to West Nile virus infection. J. Neuropathol. Exp. Neurol. (in press, JNEN 09-066R), 2009.

II. History of Neurology (Original Articles and Book Chapters) 1. Tyler KL, McHenry LC Jr. Classics in Neurology: Pseudohypertrophic muscular

  21

dystrophy and Gower's sign. Neurology. 33:88-89, 1983. 2. Tyler KL. Classics in Neurology: "Tetanoid Chorea" and progressive lenticular

degeneration. Neurology. 33:461-462, 1983. 3. Tyler KL, McHenry LC Jr. Classics in Neurology: The knee jerk and other tendon

reflexes. Neurology. 33:609-610, 1983. 4. Tyler KL. Hughlings Jackson: The early development of his ideas on epilepsy. J. Hist.

Med Allied Sci. 39:55-64, 1984. 5. Tyler HR, Tyler KL. Charles Edouard Brown-Sequard: professor of physiology and

pathology of the nervous system at Harvard Medical School. Neurology. 34:1231-1236, 1984.

6. Tyler HR, Tyler KL. Classics in Neurology: “Organic remains of a former world”.

Neurology 35:371, 1985. 7. Tyler HR, Tyler KL. Classics in Neurology: Drawings of Leonardo da Vinci. Neurology

35:636, 1985. 8. Tyler HR, Tyler KL. Classics in Neurology: Communication between lateral and third

ventricle: First description. Neurology 35: 1298, 1985. 9. Tyler KL, Tyler HR. The secret life of James Parkinson (1755-1824): The writings of Old

Hubert. Neurology. 36:222-224, 1986. 10. Tyler KL. A History of Parkinson's Disease. In: Koller WC (Ed.). Handbook of

Parkinson's Disease. M Dekker Inc., NY, 1987:1-33. 11. Tyler KL, Vignette: William G. Spiller (1863-1940). Annals Neurol. 31: 686, 1992. 12. Tyler KL. A History of Parkinson's Disease. In: Koller WC (Ed.).Handbook of

Parkinson's Disease (2nd ed.) M. Dekker Inc., NY, 1992:1-34. 13. Tyler HR, Tyler KL. Cushing: The book collector. In: Black P, Moore M, Rossitch E

(Eds.). Harvey Cushing at the Brigham. Amer. Assoc. Neurological Surgeons, Park Ridge, IL, 1995.

14. Tyler KL, Tyler HR. Sir William Richard Gowers (1845-1915): Exhumation and decoding of his shorthand publications. In: Rose FC (Ed.): A short history of neurology. The British Contribution 1660-1910. Butterworth-Heinemann, Oxford,1999:208-221.

15. Tyler KL, Roberts D, Tyler HR. The shorthand publications of Sir William Richard

Gowers. Neurology 55:289-293, 2000. 16. Tyler KL, Malessa R. The Goltz-Ferrier debates and the triumph of cerebral localizationist

theory. Neurology 55:1015-1024, 2000. 17. Tyler KL. Gowers, William Richard In: Aminoff MJ, Daroff RB (Eds.). Encyclopedia of

  22

the neurological sciences. Academic Press, Amsterdam, 2003: vol. 2:481-484. 18. Tyler KL. Mitchell, Silas Weir. In: Aminoff MJ, Daroff RB (Eds.). Encyclopedia of the

neurological sciences. Academic Press, Amsterdam, 2003: vol. 3:183-190. 19. Tyler KL. Goltz, Friedrich Leopold. In: Aminoff MJ, Daroff RB (Eds.). Encyclopedia of

the neurological sciences. Academic Press, Amsterdam, 2003: vol. 2:479-480. 20. Tyler KL. Hitzig, Eduard. In: Aminoff MJ, Daroff RB (Eds.). Encyclopedia of the

neurological sciences. Academic Press, Amsterdam, 2003: vol. 2:560-561. 21. Tyler KL, York GK, Steinberg DA et al. History of 20th century neurology: decade by

decade. Ann Neurol 53 (suppl 4): S27-S45, 2003. 22. Tyler KL. Origins and early descriptions of “Duchenne muscular dystrophy”. Muscle &

Nerve 28:402-422, 2003. 23. Tyler KL. William Richard Gowers (1845-1915). J Neurol. 250:1012-1013, 2003. 24. Tyler KL. A history of bacterial meningitis. In: Finger S, Boller F, Tyler KL (Eds.):

History of Neurology, Handbook of Clinical Neurology Series, Elsevier, NY, 2009 (In Press)

  23

III. Book Chapters 1. Folkman J, Tyler K. Tumor Angiogenesis: Its Possible Role in Metastasis and Invasion.

In: Day SB, Stacey B. et al. (ed.). Progress in Cancer Research and Therapy, Vol. 5. Cancer Invasion and Metastasis: Biological Mechanisms and Therapy. Raven Press. NY, 1977:95-103.

2. Tyler KL, Tyler HR. Huntington's Disease. In: Tyler HR and Dawson D (Eds.). Current

Neurology. Houghton Mifflin, Boston, (Volume I), 1978:116-141. 3. Tyler HR, Tyler KL. Parkinson's Disease. In: Tyler HR and Dawson D (Eds.). Current

Neurology. Houghton Mifflin, Boston, (Volume I), 1978:142-165. 4. Tyler KL. Huntington's Disease Update. In: Tyler HR and Dawson D (Eds.). Current

Neurology. Houghton Mifflin, Boston, (Volume II), 1979:157-167. 5. Tyler KL. Parkinson's Disease Update. In: Tyler HR and Dawson D (Eds.). Current

Neurology. Houghton Mifflin, Boston, (Volume II), 1979:168-181. 6. Tyler KL, Tyler HR. Neurologic Complications of Uremia. In: Eknoyan G, Knochel J

(Eds.) Systemic Consequences of Renal Failure. Grune & Stratton, 1984:311-330. 7. Tyler KL. Seizures. In: Hyman S (Ed.). Manual of Psychiatric Emergencies. Little

Brown, Boston, 1984:161-169. 8. Tyler KL, Fields BN. Reoviruses. In: Fields BN, Knipe DM, Chanock RM, Melnick JL,

Roizman B, Shope RE (Eds.): Virology. Raven Press, NY, 1985:817-822. 9. Tyler KL, Fields BN. Reovirus and its Replication. In: Fields BN, Knipe DM, Chanock RM, Melnick JL, Roizman B, Shope RE (Eds.): Virology. Raven

Press, NY, 1985:823-863. 10. Tyler KL, Fields BN. Reoviruses. In: Fields BN and Knipe DM (Eds.): Fundamental

Virology. Raven Press, NY, 1986:391-395. [republication of #8] 11. Tyler KL, Fields BN. Reovirus and its Replication. In: Fields BN and Knipe DM (Eds.):

Fundamental Virology. Raven Press, NY, 1986:397-436. [republication of #9] 12. Tyler KL, Tyler HR. Neurologic Manifestations of Endocrine Diseases. In: Asbury A,

McKahn G, McDonald WI (Eds.). Diseases of the Nervous System. Saunders, Philadelphia, 1986:1552-1562.

13. Tyler KL. Localized Infections of the Central Nervous System. In: Current Therapy in

Infectious Disease. Kass EH, Platt R (Eds.). BC Decker, Philadelphia, 1986:216-225. 14. Tyler KL, Fields BN. Reovirus Infections in Laboratory Rodents. In: Bhatt PN et al.

  24

(Eds.). Viral and Mycoplasmal Infections of Laboratory Rodents: Effects on Biomedical Research. Academic Press, NY, 1986:277-303.

15. Tyler KL, Fields BN. Principles of Virology. In: Braunwald E, Isselbacker J, Petersdorf

RG et al. (Eds.). Harrison's Principles of Internal Medicine (11th edition), McGraw Hill, NY, 1987:659-668.

16. Tyler KL. Localized Infections of the Central Nervous System. In: Current Therapy in

Internal Medicine-2. Bayless TM, Brain MC, Cherniak RM (Eds.). BC Decker, Philadelphia, 1987:231-240. [republication of #13]

17. Tyler KL. Encephalitis. In: Adelman G. (Ed.). Encyclopedia of Neuroscience.

Birkhauser, Boston, 1987:387-389. 18. Tyler KL. The Neurologic Examination (Chapter 151), Aphasia (Chapter 154), Epilepsy

(Chapter 156), Multiple Sclerosis (Chapter 161), Parkinson's Disease (Chapter 162), Chronic Progressive Myopathies and Muscular Dystrophies (Chapter 167), Amyotrophic Lateral Sclerosis (Chapter 168), Alcoholism (Chapter 176). In: Braunwald E, Isselbacher KJ, Petersdorf RG, Wilson JD, Martin JB, Fauci AS (Eds.). Harrison's Principles of Internal Medicine (11th ed.) Companion Handbook. McGraw-Hill, NY, 1988.

18. Tyler KL. Host and Viral Factors Which Influence Viral Neurotropism. In: Harding A

and Rosenberg R (Eds.). The Molecular Biology of Neurological Disease. Butterworths, London, 1988:94-108.

20. Tyler KL, Fields BN. Reovirus Infections of the Central Nervous System. In: Johnson

RT, Lyon G (Eds.). Viral Infections of the Developing Nervous System. Kluwer, Dordecht, 1988:11-19.

21. Tyler KL, Fields BN. Reoviridae: The Reoviruses. In: Lennette EH, Halonen P, Murphy

FA (Eds.). Laboratory Diagnosis of Infectious Disease, Principles and Practice (Vol. II). Springer-Verlag, NY, 1988:353-374.

22. Tyler KL, Fields BN. Pathogenesis of Neurotropic Viral Infections: In: McKendall RR

(Ed.). Viral Disease (Handbook of Clinical Neurology, revised series, Vol. 12(56). Elsevier, Amsterdam 1989:25-49.

23. Tyler KL. Fields BN. Pathogenesis of Viral Infections. In: Fields BN, Knipe DM (Eds.).

Virology (2nd ed.), Raven Press, NY 1990:191-239. 24. Tyler KL, Fields BN. Reoviridae: A Brief Introduction. In: Fields BN, Knipe DM

(Eds.). Virology (2nd ed.), Raven Press, NY, 1990:1271-1273. 25. Tyler KL. Fields BN. Reoviruses. In: Fields BN, Knipe DM (Eds.).Virology (2nd ed.),

Raven Press, NY, 1990:1307-1328.

  25

26. Lehrich JR, Tyler KL. Slow Infections of the Central Nervous System. In: Mandell GL, Douglas RG, Bennett JE (Eds.). Principles and Practice of Infectious Diseases (3rd ed.). Churchill Livingstone, NY 1990:769-777.

27. Tyler KL, Fields BN. Introduction to Viruses and Virus Diseases. In: Mandell GL,

Douglas RG, Bennett JE (Eds.). Principles and Practice of Infectious Diseases (3rd ed.), Churchill Livingstone, NY 1990:1124-1134.

28. Tyler KL. Prions. In: Mandel GL, Douglas RG, Bennett JE (Eds.). Principles and

Practice of Infectious Diseases (3rd ed.), Churchill Livingstone, NY 1990:1419-1423. 29. Tyler KL. Infections: Viruses. In: Pearlman AL and Collins R (Eds.). Neurobiology of

Disease. Oxford Univ. Press, NY 1990:435-453. 30. Tyler KL. Localized Infections of the Central Nervous System. In: Current Therapy in

Internal Medicine (3rd ed.). Kassirer JP (Ed). BC Decker, Philadelphia 1991:199-209. 31. Tyler KL, Fields BN. Pathogenesis of Viral Infections. In: Fields BN, Knipe DM (Eds.).

Fundamental Virology (2nd ed.), Raven Press, NY 1991:191-239. [republication of #23] 32. Tyler KL, Fields BN. Reoviridae: A Brief Introduction. In: Fields BN, Knipe DM (Eds.).

Fundamental Virology (2nd ed.), Raven Press, NY, 1991:583-585. [republication of #24] 33. Tyler KL, Fields BN. The Biology of Viruses. In: Wilson J, Braunwald E, Isselbacher

KJ, et al. (Eds.). Harrison's Principles of Internal Medicine (12th edition), McGraw Hill, NY, 1991:669-677.

34. Tyler KL. The Neurologic Examination (Chapter 154), Epilepsy (Chapter 157), Multiple

Sclerosis (Chapter 162), Parkinson's Disease Chapter 163), Amyotrophic Lateral Sclerosis (Chapter l65), Chronic Progressive Myopathies and Muscular Dystrophies (Chapter 170), Aphasia (Chapter 173), Alcoholism (Chapter 179). In: Wilson JD, Braunwald E, Isselbacher KJ, et al., (eds.). Harrison's Principles of Internal Medicine (12th ed.) Companion Handbook. McGraw-Hill, NY, 1991.

35. Tyler KL, Martin JB, Scheld WM. Focal Suppurative Infections of the Central Nervous

System. In: Tyler KL, Martin JB (Eds.): Infectious Diseases of the Central Nervous System, FA Davis, NY, 1993: 157-175.

36. Martin JB, Tyler KL, Scheld WM. Bacterial Meningitis. In: Tyler KL, Martin JB (Eds):

Infectious Diseases of the Central Nervous System, FA Davis, NY, 1993: 176-187. 37. Tyler KL. The Neurological Examination (Chapter 160), Epilepsy (Chapter 162), Viral

Infections of the Nervous System, Including Slow Viruses (Chapter 166), Multiple Sclerosis (Chapter 167), Parkinson's Disease (Chapter 169), Motor Neuron Disease Including ALS (Chapter 170),Aphasia (Chapter 172), Myopathies and Muscular Dystrophies (Chapter 180), Alcoholism (Chapter 185). In: Isselbacher KJ, Braunwald E,

  26

Wilson JD, et al. (Eds.). Harrison's Principles of Internal Medicine (13th ed.) Companion Handbook, McGraw-Hill, NY, 1995.

38. Tyler KL. Pathogenesis. In: Webster RG, Granoff A (Eds). Encyclopedia of Virology,

Academic Press, London, 1994: 1076-1083. 39. Tyler KL, Fields BN. The Biology of Viruses. In: Isselbacher KJ, Braunwald E, Wilson

JD, et. al.(Eds.): Harrison's Principles of Internal Medicine (13th ed.). McGraw Hill, NY, 1994:768-776.

40. Tyler KL. Viral and Prion Diseases of the Nervous System. In: Isselbacher KJ,

Braunwald E, Wilson J, Martin J, Fauci A, Kasper D (Eds.): Harrison's Principles of Internal Medicine (l3th edition), McGraw-Hill, NY, 1994: 2309-2320.

41. Tyler KL, Blume GM. Herpes Simplex Encephalitis. In: Feldman, E. (Ed.): Current

Diagnosis in Neurology, Mosby-Yearbook Inc., St. Louis, Missouri, 1994: 88-92. 42. Tyler KL. Animal Models of Reovirus Infection. In: McKendall RR, Stroop WG (Eds.): Handbook of Neurovirology. Marcel Dekker, Inc., NY,1994: 671-679. 43. Tyler KL. Prion Diseases of the Central Nervous System. In: Mandell GL, Bennett JE,

Dolin R (Eds.). Principles and Practice of Infectious Diseases (4th ed). Churchill Livingstone, NY, 1995: 881-887.

44. Tyler KL, Fields BN. Introduction to Viruses and Virus Diseases. In: Mandel GL,

Bennett JE, Dolin R (Eds.). Principles and Practice of Infectious Diseases (4th ed), Churchill Livingstone, NY, 1995:1314-1325.

45. Tyler KL. Prions. In: Mandel GL, Bennett JE, Dolin R (Eds.). Principles and Practice of

Infectious Diseases (4th ed.), Churchill Livingstone, NY, 1995:1674-76. 46. Tyler KL, Fields BN. Pathogenesis of Viral Infections. In: Fields BN, Knipe DM,

Howley PM (Eds.) Virology (3rd ed). Lippincott-Raven, Philadelphia, 1996:173-218. 47. Tyler KL, Fields BN. Reoviruses. In: Fields BN, Knipe DM, Howley PM (Eds.):

Virology (3rd ed). Lippincott-Raven, Philadelphia, 1996:1597-1623. 48. Tyler KL, Fields BN. Pathogenesis of Viral Infections. In: Fields BN, Knipe DM, Howley

PM (Eds). Fundamental Virology (3rd ed.), Lippincott-Raven, Philadelphia, 1996:161-206. [republication of #46]

49. Pfister HW, Tyler KL. Other Spirochetal Infections. In: Brand T, Caplan LR, Dichgans J,

Diener HC, Kennard C (Eds.). Neurological Disorders: Course and Treatment, Academic Press, San Diego, 1996:423-432.

50. Malessa R, Tyler KL. Viral Infections of the Central Nervous System. In: Brandt T,

  27

Caplan LR, Dichgans J, Diener HC, Kennard C (Eds.). Neurological Disorders: Course and Treatment, Academic Press, San Diego, 1996:443-454.

51. Nathanson N, and Tyler KL. Entry, Dissemination, Shedding, and Transmission of

Viruses. In: Nathanson N (Ed.) Viral Pathogenesis, Lippincott-Raven, Philadelphia, 1997:13-33.

52. Virgin HW IVth, Tyler KL, Dermody TS. Reovirus. In: Nathanson N (Ed.). Viral

Pathogenesis, Lippincott-Raven, Philadelphia, 1997:669-699. 53. Tyler KL, Gonzalez-Scarano F. Viral Diseases of the Central Nervous System: Acute

Infections. In: Nathanson N (Ed.). Viral Pathogenesis, Lippincott-Raven, Philadelphia, 1997:837-853.

54. Nathanson N. and Tyler KL. The Pathogenesis of Viral Infections. In: Collier L (ed.).

Topley & Wilson's Microbiology and Microbial Infections (9th ed.), Vol. I: Mahy BWJ, Collier LH (Eds.). Virology, Edward Arnold, London, 1997:149-172.

55. Tyler KL. Aseptic meningitis, viral encephalitis, and prion diseases. In: Fauci AS,

Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL (Eds.). Harrison’s Principles of Internal Medicine (14th ed.), McGraw-Hill, NY, 1998:2439-2451.

56. Tyler KL. The Neurological Examination (Chapter 171), Bacterial Infections of the

Central Nervous System (Chapter 176), Aseptic Meningitis, Viral Encephalitis, and Prion Diseases (Chapter 177), Motor Neuron Disease, Including ALS (Chapter 182), Aphasia (Chapter 183). In: Fauci AS, Braunwald E, Isselbacher KJ, et al. (Eds.) Harrison’s Principles of Internal Medicine (14th ed.) Companion Handbook, McGraw-Hill, NY, 1998.

57. Tyler KL. Prognosis of acute viral encephalitis. In: Gilchrist JM (Ed). Prognosis in

Neurology. Butterworth-Heinemann, Boston,1998:233-238. 58. Tyler KL, Encephalitis. In Adelman G., Smith BH (Eds.). Encyclopedia of Neuroscience

(2nd ed.) Elsevier, Amsterdam, 1999:646-649. 59. Anderson CA, Tyler KL. Meningitis. In: Adelman G, Smith B (Eds.). Encyclopedia of

Neuroscience (2nd edition), Elsevier Science, Amsterdam, 1999:1145-1148. 60. Tyler KL, Pathogenesis. In: Granoff A, Webster RG (Eds.). Encyclopedia of Virology (2nd

ed.), Academic Press, London, 1999:1175-1184. 61. Tyler KL, Reovirus: General features. In: Webster RG, Granoff A (Eds.). Encyclopedia of

Virology (2nd ed.), Academic Press, London,1999:1454-1464. 62. Tyler KL. Prion diseases of the central nervous system. In: Swartz MN, Remington JS

(Eds.). Current Clinical Topics in Infectious Disease (19th ed.), Blackwell Science, Malden,

  28

MA 1999:226-251. 63. Dermody TS, Tyler KL. Introduction to viruses and viral diseases. In: Mandell GL,

Bennett JE, Dolin R (Eds.) Principles and Practice of Infectious Diseases (5th ed.), Churchill Livingstone, Philadelphia, 2000:1536-1552.

64. Tyler KL. Prions and prion diseases of the central nervous system (Transmissible

neurodegenerative diseases). In: Mandell GL, Bennett JE, Dolin R (Eds.). Principles and Practice of Infectious Diseases (5th ed.), Churchill Livingstone, Philadelphia, 2000:1971-1985.

65. Corboy JR, Tyler KL. Neurovirology. In: Bradley WG, Daroff RB, Fenichel GM, Marsden

CD (Eds.). Neurology in Clinical practice (3rd edition), Butterworth-Heinemann, Boston 2000:823-840.

66. Debiasi R, Tyler KL. Recurrent aseptic meningitis. In: Davis LE, Kennedy PGE (Eds.).

Infectious diseases of the nervous system, Butterworth Heinemann, Oxford England, 2000:445-479.

67. Tyler KL. Diseases of the central nervous system caused by prions-I. In Rose BD (Ed.).

UpToDate, [Infectious Disease Section, M. Hirsch, Ed.] (CD-ROM). Up To Date Inc., Wellesley, MA. 2000 [Updates 2001-2006]

68. Tyler KL. Diseases of the central nervous system caused by prions-II. In Rose BD (Ed.).

UpToDate, [Infectious Disease Section, M. Hirsch, Ed.] (CD-ROM). Up To Date Inc., Wellesley, MA. 2000 [Updates 2001-2006].

69. Tyler KL. Prions. In Rose BD (Ed.). UpToDate, [Infectious Disease Section, M. Hirsch,

Ed.] (CD-ROM). Up To Date Inc., Wellesley, MA. 2000 [Updates 2001-2006]. 70. Roos KL, Tyler KL. Bacterial meningitis and other suppurative infections. In: Braunwald

E, Fauci AS, Kasper DL, Hauser SI, Longo DI, Jameson JL (Eds.). Harrison’s Principles of Internal Medicine (15th edition). McGraw-Hill, NY:2001:2462-2471.

71. Tyler KL. Viral meningitis and encephalitis. In: Braunwald E, Fauci AS, Kasper DL,

Hauser SI, Longo DI, Jameson JL (Eds.). Harrison’s Principles of Internal Medicine (15th edition). McGraw-Hill, NY:2001:2471-2481.

72. Tyler KL, Nathanson N. Pathogenesis of viral infections. In: Knipe DM, Howley PM, et

al. (Eds.) Fields Virology (4th edition), Lippincott-Williams & Wilkins, Philadelphia, 2001: 199-243.

73. Tyler KL. Mammalian Reoviruses. In: Knipe DM, Howley PM, et al. (Eds.) Fields

Virology (4th edition), Lippincott-Williams & Wilkins, Philadelphia , 2001:1729-1745.

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74. Tyler KL, Pathogenesis of viral infections. In: Knipe DM, Howley PM (Eds.). Fundamental Virology (4th edition), Lippincott-William & Wilkins, Philadelphia, 2001:199-243. [republication of #72]

75. DeBiasi R, Tyler KL. Viral meningitis and encephalitis. Infectious Disease, Continuum 8:

59-87, 2002 (American Academy of Neurology, published by Lippincott Williams & Wilkins, Philadelphia).

76. Malessa R, Tyler KL. Acute viral infections of the nervous system. In: Brandt T, Caplan

LR, Dichgans J, Diener HC, Kennard C (Eds.). Neurological disorders: Course and treatment, 2nd edition. Academic Press, Amsterdam, 2003:601-613.

77. DeBiasi RL, Tyler KL. Infections of the nervous system. Viral infections. In: Bradley WG,

Daroff RB, Fenichel GM, Jankovic J (Eds.). Neurology in Clinical practice (4th edition), Butterworth-Heinemann, Philadelphia, 2004:1515-1543.

78. Corboy JR, Tyler KL. Neurovirology. In: Bradley WG, Daroff RB, Fenichel GM,

Jankovic J (Eds.). Neurology in Clinical practice (4th edition), Butterworth-Heinemann, Philadelphia, 2004:831-848.

79. Tyler KL. Acute viral myelitis. In: Scheld M, Whitley RJ, Marra CM. Infections of the

central nervous system (3rd edition). Lippincott William & Wilkins, Philadelphia, 2004:305-322.

80. Anderson CA, Tyler KL. Meningitis. In: Adelman G, Smith BH (Eds.): Encyclopedia of

Neuroscience, 3rd edition (CD-ROM), Elsevier, 2004. 81. Tyler KL. Meningitis. In: Adelman G, Smith BH (Eds): Encyclopedia of Neuroscience, 3rd

edition (CD-ROM), Elsevier, 2004. 82. Roos K, Tyler KL. Meningitis, encephalitis, brain abscess and empyema. Chapter 360. In:

Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL (Eds). Harrison’s Principles of Internal Medicine (16th edition). McGraw Hill, Boston, 2005:2471-2490.

83. Dermody TS, Tyler KL. Introduction to viruses and viral diseases. In: Mandell GL,

Bennett JE, Dolin R (Eds.). Principles and Practice of Infectious Diseases (6th ed.), Churchill Livingstone, Philadelphia, 2005:1729-1742.

84. Tyler KL. Prions and prion diseases of the central nervous system (Transmissible

neurodegenerative diseases). In: Mandell GL, Bennett JE, Dolin R (Eds.). Principles and Practice of Infectious Diseases (6th ed.), Churchill Livingstone, Philadelphia, 2005:2219-2235.

85. Tyler KL, Anderson CA. Biology and genetics of prions. UpToDate. (CD-ROM) Ver 13.2,

2005. (see also 67-69 for earlier editions)

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86. Tyler KL, Anderson CA. Diseases of the nervous system caused by prions. UpToDate (CD-ROM), Ver 13.2, 2005. (see also 67-9 for earlier versions)

87. Tyler KL, Anderson CA. Creutzfeldt-Jakob Disease. UpToDate (CD-ROM), Ver 13.2,

2005 (see also #67-9 for earlier versions) 88. Tyler KL, Anderson CA. Variant Creutzfeldt-Jakob Disease. UpToDate (CD-ROM), Ver

13.2, 2005 (see also #67-9 for earlier versions) 89. Nathanson N, Tyler KL. Pathogenesis of Viral Infections. In: Collier L (Ed.). Topley &

Wilson's Microbiology and Microbial Infections (10th ed.), Vol. I: Virology; Mahy BWJ, ter Meulen V (Eds.). Hodder Arnold & ASM Press, London, 2005:236-269.

90. Gilden DH, Tyler KL. Herpesvirus infection and peripheral neuropathy. In: Dyck PJ,

Thomas PK (Eds.). Peripheral neuropathy (4th edition), Elsevier Saunders, Philadelphia, 2005:2117-2127.

91. DeBiasi R, Tyler KL. Viral meningitis and encephalitis. In: Infectious Disease, Continuum

(American Academy of Neurology, published by Lippincott Williams & Wilkins, Philadelphia), 12(2): 58-94, 2006.

92. Roos KL, Tyler KL. Meningitis, encephalitis, brain abscess, and empyema. In: Hauser

SL (Ed.): Harrison’s Neurology in Clinical Medicine. McGraw-Hill, NY, 2006:423-455. (updated reprinting of #82) 93. Brown HG, Lee JM, Tyler KL, Anderson CA. Creutzfeldt-Jakob Disease. In: UpToDate

(CD-ROM), Ver 14.2, 2006. (see #67-9, 85-8 for earlier versions) 94. Brown HG, Lee JM, Tyler KL, Anderson CA. Variant Creutzfeldt-Jakob Disease. In:

UpToDate (CD-ROM), Ver 14.2, 2006. (see #67-9, 85-8 for earlier versions) 95. Brown HG, Lee JM, Tyler KL, Anderson CA. Diseases of the central nervous system

caused by prions. In: UpToDate (CD-ROM), Ver 14.2, 2006. (see #67-9, 85-8 for earlier versions)

96. Brown HG, Lee JM, Tyler KL, Anderson CA. biology and genetics of prions. In:

UpToDate (CD-ROM), Ver 14.2, 2006. (see #67-9, 85-8 for earlier versions) 97. Anderson CA, Tyler KL. Prion diseases. Chapter 56, In: Engleberg NC, DiRita V,

Dermody TS (Eds.): Schaechter’s Mechanisms of Microbial Disease, 4th edition, Lippincott William & Wilkins, Philadelphia, 2007:534-540.

98. DeBiasi RL, Tyler KL. Infections of the central nervous system. Chapter 61, In: Engleberg

NC, DiRita V, Dermody TS (Eds.): Schaechter’s Mechanisms of Microbial Disease, 4th edition, Lippincott William & Wilkins, Philadelphia, 2007:588-602.

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99. Schiff LA, Nibert M, Tyler KL. Orthoreoviruses and their replication. In: Knipe DM, Howley PM (Eds.): Fields’ Virology (5th edition), Lippincott William & Wilkins, Philadelphia, 2007:1853-1915.

100. Solbrig MV, Tyler KL. Infections of the nervous system: Viral infections (Chapter 57B).

In: Bradley WG, Daroff RB, Fenichel GM, Jankovic J. (Eds.): Neurology in Clinical Practice, 5th edition, Butterworth-Heinemann Elsevier, Philadelphia, 2008:1457-1488.

101. Roos K, Tyler KL. Meningitis, encephalitis, brain abscess and empyema. In Fauci AS,

Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J (Editors): Harrison’s principles of internal medicine (17th edition), McGraw Hill, NY, 2008:2621-2641.

102. Tyler KL, Gilden DH. Clinical management of viral encephalitis (Chapter 19). In: Reiss C

(Ed.). Neurotropic viral infections. Cambridge University Press, 2008:347-361. 103. Beckham JD, Tyler KL. Clinical manifestations of neurological disease. In: Diamond M

(Ed.): West Nile encephalitis virus infection: pathogenesis and the host immune response. Springer, NY, 2009:69-95.

104. DeBiasi R, Tyler KL. Orthoreoviruses and orbiviruses. In: Mandell GL, Bennett JE, Dolin

R (Eds): Principles and practice of infectious diseases (7th ed). Elsevier, NY, 2009:2097-99. 105. DeBiasi R, Tyler KL. Coltiviruses and seadornaviruses (Colorado Tick Fever). In:

Mandell GL, Bennett JE, Dolin R (Eds): Principles and practice of infectious diseases (7th ed). Elsevier, NY, 2009:2101-3.

106. Bosque P, Tyler KL. Prions and prion diseases of the nervous system (Transmissible

neurodegenerative diseases) In: Mandell GL, Bennett JE, Dolin R (Eds): Principles and practice of infectious diseases (7th ed). Elsevier, NY, 2009:2423-2438.

107. Beckham JD, Tyler KL. Encephalitis. In: Mandell GL, Bennett JE, Dolin R (Eds):

Principles and practice of infectious diseases (7th ed). Elsevier, NY, 2009:1243-1263. 104. Kleinschmidt-DeMasters BK, Tyler KL. Infectious and Inflammatory Disorders. In:

Perrie A and Brat D (Eds). Practical surgical neuropathology: A diagnostic approach. Elsevier, NY (in press), 2009.

IV. Books 1. Tyler KL, Martin JB (Eds). Infectious Diseases of the Central Nervous

System. Contemporary Neurology Series 41. FA Davis, Philadelphia, 1993. 2. Tyler KL, Oldstone MBA (Eds). Reoviruses I: Structure, Proteins and Genetics. . Current

Topics in Microbiology & Immunology Vol. 233/1, Springer-Verlag, Heidelberg, 1998.

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3. Tyler KL, Oldstone MBA (Eds.). Reoviruses II: Cytopathogenicity and Pathogenesis.

Current Topics in Microbiology and Immunology. Vol. 233/2, Springer-Verlag, Heidelberg, 1998.

4. Tyler KL. Associate Editor, Aminoff MJ, Daroff RB (Editors): Encyclopedia of the

Neurological Sciences, Academic Press, Amsterdam, 2003. 5. Finger S, Boller F, Tyler KL (Eds). History of Neurology. Handbook of Clinical

Neurology Series. Elsevier, NY, 2009 (in press). V. Editorials & Commentaries 1. Tyler KL. Prions [editorial] Infections in Medicine 11:382-383, 1994. 2. Tyler KL, Diagnosis of herpes simplex encephalitis: Application of polymerase chain

reaction to cerebrospinal fluid from brain-biopsied patients and correlation with disease. [commentary] Neurology Network Commentary 1:9-13, 1997.

3. Tyler KL, Cerebrospinal-fluid polymerase chain reaction and the diagnosis of viral

infections of the central nervous system. [commentary] Neurology Network Commentary 1:276-282, 1997.

4. Tyler KL, Rabies [commentary]. Neurology Network Commentary 3:64-67, 1999. 5. Tyler KL. Viruses in Amyotrophic Lateral Sclerosis. [commentary] Lancet Neurology

Network 4:1, 2001 (e-published at www.lancetneuronet.com). 6. Tyler KL. West Nile Virus encephalitis in America . [editorial] N Engl J Med 344: 1858-

1859, 2001. 7. Tyler KL, McArthur JC. Through a glass darkly: The role of CSF viral load (HIV-1 RNA)

measurements in understanding the pathogenesis of HIV infection of the CNS. [editorial]. Arch Neurol 59:909-912, 2002.

8. Tyler KL. Creutzfeldt-Jakob Disease [editorial perspective]. N Engl J Med. 348: 681-682,

2003. 9. Tyler KL. Human herpesvirus 6 and multiple sclerosis [editorial]. J Infect Dis. 187:1360-

1364, 2003. 10. Tyler KL. The uninvited guest. JC virus infection of neurons in PML [editorial].

Neurology 61:734-735, 2003. 11. Tyler KL. Commentary: Gibbs CJ Jr, Amyx HL, Bacote A, Masters CL, Gajdusek DC.

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Oral transmission of Kuru, Creutzfeldt-Jakob disease, and scrapie to non-human primates. J Infect Dis 1980; 142:205-208. [Centennial Perspective]. J Infect Dis 190:653-660, 2004.

12. Davis LE, Tyler KL. Molecular diagnosis of CNS viral infections. [editorial

commentary]. Journal of Neurology, Neurosurgery, and Psychiatry 76:10, 2005. [PMC1739295]

13. Tyler KL. Rabies in four organ transplant recipients [article commentary]. Journal Watch

Neurology (from the publishers of the N Engl J Med) 7:55, 2005. 14. Gilden DH, Tyler KL. Bell’s palsy- Is glucocorticoid treatment enough ? [editorial]. N.

Engl. J. Med. 357:1653-5, 2007. 15. Tyler KL. Bacterial meningitis: An urgent need for further research to reduce mortality

and morbidity [editorial]. Neurology 70:2095-6, 2008. 16. Bosque PJ, Tyler KL. Prions’ travels-Feces and transmission of prion diseases. [editorial]

J. Infect. Dis. 198:8-9. 2008. 17. Tyler KL. Cortical demyelination in MS and progressive multifocal leukoencephalopathy

[article commentary]. Journal Watch Neurology (from publishers of the N Engl J Med) 10:51, 2008.

18. Tyler KL. PML’s 50th birthday- New insights into pathogenesis [editorial]. Annals

Neurol. 64:359-61, 2008.