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LAMPIRAN PROBIT EMBRIO
Uji Normalitas
One-Sample Kolmogorov-Smirnov Test
Jam24Jam48Jam72Jam96
N15151515
Normal Parametersa,bMean39,333342,333347,000067,6667
Std. Deviation17,5119017,5119023,4368521,70144
Most Extreme DifferencesAbsolute,119,114,166,182
Positive,119,106,166,149
Negative-,094-,114-,100-,182
Kolmogorov-Smirnov Z,460,440,645,703
Asymp. Sig. (2-tailed),984,990,800,706
a. Test distribution is Normal.
b. Calculated from data.
Probit Analysis
Data Information
N of Cases
Valid60
RejectedOut of Rangea0
Missing0
Number of Responses > Number of Subjects0
Control Group0
Dosis438 mg12
578 mg12
763 mg12
1007 mg12
1328 mg12
a. Cases rejected because of out of range group values.
Convergence Information
Number of IterationsOptimal Solution Found
PROBIT15Yes
Parameter Estimates
ParameterEstimateStd. ErrorZSig.95% Confidence Interval
Lower BoundUpper Bound
PROBITaJam,011,00116,701,000,010,012
Interceptb438 mg-1,367,058-23,648,000-1,425-1,310
578 mg-1,002,055-18,316,000-1,056-,947
763 mg-,715,054-13,348,000-,768-,661
1007 mg-,372,053-7,019,000-,425-,319
1328 mg,103,0541,911,056,049,157
a. PROBIT model: PROBIT(p) = Intercept + BX
b. Corresponds to the grouping variable Dosis.
Chi-Square Tests
Chi-SquaredfbSig.
PROBITPearson Goodness-of-Fit Test246,18254,000a
Parallelism Test30,3234,000
a. Since the significance level is less than ,150, a heterogeneity factor is used in the calculation of confidence limits.
b. Statistics based on individual cases differ from statistics based on aggregated cases.
Cell Counts and Residuals
NumberDosisJamNumber of SubjectsObserved ResponsesExpected ResponsesResidualProbability
PROBIT1124,0001001513,4101,590,134
2148,0001001519,850-4,850,199
3172,0001001527,869-12,869,279
4196,0001004037,2032,797,372
5124,0001001513,4101,590,134
6148,0001002519,8505,150,199
7172,0001002527,869-2,869,279
8196,0001005537,20317,797,372
9124,0001001513,4101,590,134
10148,0001002019,850,150,199
11172,0001002027,869-7,869,279
12196,0001003537,203-2,203,372
13224,0001002522,9212,079,229
14248,0001002531,519-6,519,315
15272,0001002541,256-16,256,413
16296,0001004051,567-11,567,516
17224,0001004022,92117,079,229
18248,0001004031,5198,481,315
19272,0001004041,256-1,256,413
20296,0001005551,5673,433,516
21224,0001003022,9217,079,229
22248,0001003031,519-1,519,315
23272,0001003041,256-11,256,413
24296,0001006051,5678,433,516
25324,0001003532,4752,525,325
26348,0001004042,300-2,300,423
27372,0001004052,632-12,632,526
28396,0001005562,789-7,789,628
29324,0001005032,47517,525,325
30348,0001005042,3007,700,423
31372,0001005552,6322,368,526
32396,0001006562,7892,211,628
33324,0001003532,4752,525,325
34348,0001004042,300-2,300,423
35372,0001004052,632-12,632,526
36396,0001006562,7892,211,628
37424,0001004545,549-,549,455
38448,0001005555,900-,900,559
39472,0001005565,862-10,862,659
40496,0001009074,82315,177,748
41424,0001005545,5499,451,455
42448,0001005555,900-,900,559
43472,0001005565,862-10,862,659
44496,0001009074,82315,177,748
45424,0001004545,549-,549,455
46448,0001004555,900-10,900,559
47472,0001005565,862-10,862,659
48496,0001008074,8235,177,748
49524,0001005564,191-9,191,642
50548,0001006073,362-13,362,734
51572,0001009581,16713,833,812
52596,00010010087,37512,625,874
53524,0001007564,19110,809,642
54548,0001008073,3626,638,734
55572,0001008581,1673,833,812
56596,0001009587,3757,625,874
57524,0001005564,191-9,191,642
58548,0001005573,362-18,362,734
59572,0001007081,167-11,167,812
60596,0001009087,3752,625,874
Confidence Limits
DosisProbability95% Confidence Limits for Jam
EstimateLower BoundUpper Bound
PROBITa438 mg,010-88,429-144,073-54,221
,020-63,290-110,829-33,651
,030-47,340-89,848-20,488
,040-35,341-74,145-10,507
,050-25,581-61,438-2,321
,060-17,274-50,6814,704
,070-9,990-41,30310,919
,080-3,468-32,95816,534
,0902,463-25,41721,690
,1007,923-18,52426,485
,15030,5289,35746,993
,20048,49430,43664,372
,25063,90747,47580,327
,30077,74961,86295,570
,35090,57574,472110,415
,400102,74585,904125,036
,450114,52196,581139,566
,500126,109106,809154,145
,550137,698116,830168,931
,600149,473126,853184,114
,650161,644137,087199,934
,700174,470147,766216,711
,750188,312159,199234,907
,800203,725171,846255,254
,850221,691186,504279,054
,900244,296204,855309,092
,910249,756209,275316,360
,920255,687214,073324,259
,930262,209219,343332,950
,940269,493225,223342,661
,950277,800231,923353,744
,960287,560239,787366,773
,970299,559249,444382,800
,980315,509262,267404,121
,990340,648282,449437,754
578 mg,010-122,162-187,718-82,432
,020-97,022-154,254-62,081
,030-81,072-133,079-49,113
,040-69,074-117,189-39,319
,050-59,314-104,295-31,321
,060-51,006-93,347-24,486
,070-43,722-83,771-18,469
,080-37,201-75,221-13,059
,090-31,269-67,466-8,117
,100-25,809-60,348-3,547
,150-3,204-31,16315,657
,20014,762-8,45831,410
,25030,17510,45645,490
,30044,01626,78758,789
,35056,84241,19671,835
,40069,01354,13784,948
,45080,78865,98798,304
,50092,37777,088112,010
,550103,96687,747126,158
,600115,74198,235140,877
,650127,912108,810156,355
,700140,738119,745172,876
,750154,579131,372190,879
,800169,992144,169211,075
,850187,958158,945234,757
,900210,563177,392264,699
,910216,023181,830271,949
,920221,955186,644279,832
,930228,476191,931288,506
,940235,760197,827298,202
,950244,068204,543309,269
,960253,828212,422322,282
,970265,826222,096338,293
,980281,776234,935359,597
,990306,916255,135393,212
763 mg,010-148,628-222,510-104,109
,020-123,489-188,959-83,846
,030-107,539-167,709-70,953
,040-95,540-151,748-61,230
,050-85,780-138,783-53,301
,060-77,473-127,765-46,537
,070-70,189-118,118-40,592
,080-63,667-109,493-35,255
,090-57,735-101,662-30,390
,100-52,276-94,464-25,900
,150-29,671-64,817-7,159
,200-11,705-41,5067,989
,2503,708-21,79321,270
,30017,550-4,43133,537
,35030,37611,23845,324
,40042,54725,59057,025
,45054,32238,86968,952
,50065,91151,27681,353
,55077,49963,02594,411
,60089,27574,368108,275
,650101,44585,589123,106
,700114,27297,006139,146
,750128,113108,993156,788
,800143,526122,063176,711
,850161,492137,052200,181
,900184,097155,669229,953
,910189,557160,137237,172
,920195,488164,981245,025
,930202,010170,297253,670
,940209,294176,222263,337
,950217,601182,966274,376
,960227,361190,874287,360
,970239,360200,577303,342
,980255,310213,448324,615
,990280,450233,685358,192
1007 mg,010-180,228-264,078-129,877
,020-155,089-230,475-109,666
,030-139,139-209,180-96,817
,040-127,140-193,177-87,136
,050-117,380-180,172-79,248
,060-109,073-169,113-72,524
,070-101,789-159,425-66,620
,080-95,267-150,759-61,325
,090-89,336-142,884-56,503
,100-83,876-135,643-52,058
,150-61,271-105,745-33,566
,200-43,305-82,117-18,736
,250-27,892-61,986-5,873
,300-14,051-44,0695,839
,350-1,224-27,65916,885
,40010,946-12,32927,609
,45022,7222,19238,294
,50034,31016,08049,213
,55045,89929,45260,648
,60057,67442,41172,896
,65069,84555,09486,266
,70082,67167,728101,088
,75096,51380,673117,773
,800111,92694,473136,966
,850129,892110,017159,880
,900152,497129,064189,222
,910157,957133,607196,366
,920163,888138,524204,147
,930170,410143,910212,721
,940177,694149,904222,320
,950186,001156,716233,290
,960195,761164,692246,207
,970207,760174,464262,119
,980223,710187,409283,318
,990248,849207,734316,808
1328 mg,010-224,067-321,944-165,397
,020-198,928-288,313-145,214
,030-182,978-266,994-132,390
,040-170,979-250,967-122,732
,050-161,219-237,939-114,867
,060-152,912-226,857-108,166
,070-145,628-217,146-102,286
,080-139,106-208,456-97,015
,090-133,175-200,556-92,217
,100-127,715-193,289-87,797
,150-105,110-163,251-69,446
,200-87,144-139,451-54,788
,250-71,731-119,102-42,143
,300-57,889-100,903-30,713
,350-45,063-84,121-20,039
,400-32,893-68,293-9,813
,450-21,117-53,098,198
,500-9,529-38,29410,201
,5502,060-23,68820,401
,60013,835-9,11631,036
,65026,0065,56742,407
,70038,83220,50454,926
,75052,67435,87069,189
,80068,08751,97886,075
,85086,05369,518106,993
,900108,65890,176134,724
,910114,11894,998141,590
,920120,049100,181149,104
,930126,571105,822157,424
,940133,855112,061166,777
,950142,162119,111177,509
,960151,922127,321190,192
,970163,921137,327205,871
,980179,871150,514226,827
,990205,010171,114260,041
a. A heterogeneity factor is used.
Relative Median Potency Estimates
(I) Dosis(J) Dosis95% Confidence Limits
EstimateLower BoundUpper Bound
PROBIT1233,73211,75060,811
360,19936,38193,020
491,79963,716133,639
5135,63899,704191,951
21-33,732-60,811-11,750
326,4665,73051,110
458,06734,99689,797
5101,90672,143146,950
32-26,466-51,110-5,730
1-60,199-93,020-36,381
431,60010,69757,257
575,43949,611112,643
42-58,067-89,797-34,996
1-91,799-133,639-63,716
3-31,600-57,257-10,697
543,83921,14273,158
52-101,906-146,950-72,143
1-135,638-191,951-99,704
3-75,439-112,643-49,611
4-43,839-73,158-21,142
Uji NormalitasOne-Sample Kolmogorov-Smirnov Test
Dosis438mgDosis578mgDosis763mgDosis1007mgDosis1328mg
N1212121212
Normal Parametersa,bMean24,583336,666747,500060,416776,2500
Std. Deviation12,6954411,5470110,7661116,5774117,07271
Most Extreme DifferencesAbsolute,237,220,257,378,163
Positive,237,220,257,378,163
Negative-,225-,156-,123-,176-,123
Kolmogorov-Smirnov Z,821,761,8901,310,564
Asymp. Sig. (2-tailed),511,608,406,065,908
a. Test distribution is Normal.
b. Calculated from data.
Probit Analysis
Data Information
N of Cases
Valid60
RejectedOut of Rangea0
Missing0
Number of Responses > Number of Subjects0
Control Group0
Waktu24 jam15
48 jam15
72 jam15
96 jam15
a. Cases rejected because of out of range group values.
Convergence Information
Number of IterationsOptimal Solution Found
PROBIT13Yes
Parameter Estimates
ParameterEstimateStd. ErrorZSig.95% Confidence Interval
Lower BoundUpper Bound
PROBITaDosis,002,00028,188,000,001,002
Interceptb24 jam-1,620,059-27,374,000-1,679-1,560
48 jam-1,532,059-26,171,000-1,591-1,474
72 jam-1,397,058-24,186,000-1,455-1,339
96 jam-,788,055-14,206,000-,844-,733
a. PROBIT model: PROBIT(p) = Intercept + BX
b. Corresponds to the grouping variable Waktu.
Chi-Square Tests
Chi-SquaredfbSig.
PROBITPearson Goodness-of-Fit Test195,85955,000a
Parallelism Test32,9653,000
a. Since the significance level is less than ,150, a heterogeneity factor is used in the calculation of confidence limits.
b. Statistics based on individual cases differ from statistics based on aggregated cases.
Cell Counts and Residuals
NumberWaktuDosisNumber of SubjectsObserved ResponsesExpected ResponsesResidualProbability
PROBIT11438,0001001517,979-2,979,180
21578,0001002524,468,532,245
31763,0001003534,670,330,347
411007,0001004549,903-4,903,499
511328,0001005569,604-14,604,696
61438,0001001517,979-2,979,180
71578,0001004024,46815,532,245
81763,0001005034,67015,330,347
911007,0001005549,9035,097,499
1011328,0001007569,6045,396,696
111438,0001001517,979-2,979,180
121578,0001003024,4685,532,245
131763,0001003534,670,330,347
1411007,0001004549,903-4,903,499
1511328,0001005569,604-14,604,696
162438,0001001520,357-5,357,204
172578,0001002527,288-2,288,273
182763,0001004037,9402,060,379
1921007,0001005553,3781,622,534
2021328,0001006072,583-12,583,726
212438,0001002520,3574,643,204
222578,0001004027,28812,712,273
232763,0001005037,94012,060,379
2421007,0001005553,3781,622,534
2521328,0001008072,5837,417,726
262438,0001002020,357-,357,204
272578,0001003027,2882,712,273
282763,0001004037,9402,060,379
2921007,0001004553,378-8,378,534
3021328,0001005572,583-17,583,726
313438,0001001524,397-9,397,244
323578,0001002531,962-6,962,320
333763,0001004043,185-3,185,432
3431007,0001005558,713-3,713,587
3531328,0001009576,90318,097,769
363438,0001002524,397,603,244
373578,0001004031,9628,038,320
383763,0001005543,18511,815,432
3931007,0001005558,713-3,713,587
4031328,0001008576,9038,097,769
413438,0001002024,397-4,397,244
423578,0001003031,962-1,962,320
433763,0001004043,185-3,185,432
4431007,0001005558,713-3,713,587
4531328,0001007076,903-6,903,769
464438,0001004046,624-6,624,466
474578,0001004055,571-15,571,556
484763,0001005566,901-11,901,669
4941007,0001009079,64510,355,796
5041328,00010010091,0618,939,911
514438,0001005546,6248,376,466
524578,0001005555,571-,571,556
534763,0001006566,901-1,901,669
5441007,0001009079,64510,355,796
5541328,0001009591,0613,939,911
564438,0001003546,624-11,624,466
574578,0001006055,5714,429,556
584763,0001006566,901-1,901,669
5941007,0001008079,645,355,796
6041328,0001009091,061-1,061,911
Confidence Limits
WaktuProbability95% Confidence Limits for Dosis
EstimateLower BoundUpper Bound
PROBITa24 jam,010-440,149-657,543-269,965
,020-270,397-463,896-117,884
,030-162,694-341,376-21,051
,040-81,674-249,43552,019
,050-15,770-174,821111,629
,06040,325-111,455162,509
,07089,509-56,019207,244
,080133,547-6,494247,409
,090173,59838,447284,039
,100210,46579,721317,851
,150363,105249,436459,011
,200484,418382,572572,948
,250588,494495,134672,354
,300681,958594,597763,244
,350768,566685,172849,060
,400850,748769,575932,034
,450930,260849,7661013,783
,5001008,512927,3121095,609
,5501086,7641003,5951178,698
,6001166,2761079,9591264,274
,6501248,4581157,8431353,767
,7001335,0661238,9651449,036
,7501428,5301325,6161552,738
,8001532,6061421,2441669,077
,8501653,9191531,8331805,562
,9001806,5591669,9881978,282
,9101843,4261703,2282020,128
,9201883,4771739,2912065,636
,9301927,5151778,8922115,726
,9401976,6991823,0612171,728
,9502032,7941873,3672235,667
,9602098,6981932,3882310,870
,9702179,7182004,8392403,430
,9802287,4212100,9942526,628
,9902457,1732252,2552721,096
48 jam,010-494,456-717,927-319,819
,020-324,703-524,106-167,912
,030-217,001-401,443-71,222
,040-135,980-309,3721,718
,050-70,076-234,63361,203
,060-13,982-171,147111,962
,07035,202-115,592156,578
,08079,240-65,947196,625
,090119,292-20,888233,136
,100156,15920,506266,828
,150308,798190,845407,365
,200430,112324,663520,620
,250534,188437,969619,282
,300627,651538,228709,375
,350714,259629,633794,361
,400796,441714,869876,502
,450875,953795,866957,445
,500954,205874,1641038,519
,5501032,457951,1281120,927
,6001111,9691028,0921205,903
,6501194,1521106,4951294,877
,7001280,7591188,0621389,701
,7501374,2231275,0921493,024
,8001478,2991371,0431609,040
,8501599,6121481,9101745,247
,9001752,2521620,3101917,722
,9101789,1191653,5961959,522
,9201829,1701689,7052004,984
,9301873,2081729,3512055,029
,9401922,3921773,5662110,985
,9501978,4871823,9182174,878
,9602044,3911882,9862250,034
,9702125,4111955,4862342,545
,9802233,1142051,6952465,690
,9902402,8662203,0202660,093
72 jam,010-578,759-811,736-397,003
,020-409,007-617,744-245,267
,030-301,304-494,936-148,721
,040-220,284-402,730-75,916
,050-154,380-327,863-16,559
,060-98,285-264,24934,073
,070-49,101-208,56878,563
,080-5,063-158,797118,483
,09034,988-113,609154,866
,10071,855-72,086188,428
,150224,49598,946328,272
,200345,808233,547440,743
,250449,884347,743538,515
,300543,348448,999627,612
,350629,955541,493711,509
,400712,138627,884792,495
,450791,650710,062872,257
,500869,902789,526952,165
,550948,154867,6011033,463
,6001027,666945,5911117,412
,6501109,8481024,9201205,460
,7001196,4561107,3071299,464
,7501289,9191195,0581402,066
,8001393,9951291,6421517,449
,8501515,3091403,0681653,097
,9001667,9481541,9761825,064
,9101704,8161575,3611866,766
,9201744,8671611,5671912,130
,9301788,9051651,3111962,077
,9401838,0891695,6242017,934
,9501894,1831746,0782081,726
,9601960,0871805,2512156,777
,9702041,1081877,8632249,176
,9802148,8101974,1962372,196
,9902318,5632125,6752566,446
96 jam,010-957,901-1237,021-741,307
,020-788,148-1042,491-590,109
,030-680,446-919,235-494,011
,040-599,425-826,619-421,616
,050-533,521-751,360-362,651
,060-477,427-687,365-312,401
,070-428,243-631,305-268,290
,080-384,205-581,156-228,747
,090-344,153-535,589-192,744
,100-307,286-493,681-159,566
,150-154,647-320,624-21,748
,200-33,333-183,73788,438
,25070,743-66,915183,584
,300164,20637,370269,652
,350250,814133,345350,068
,400332,996223,690427,100
,450412,508310,287502,443
,500490,760394,584577,517
,550569,012477,817653,657
,600648,524561,164732,249
,650730,707645,900814,890
,700817,314733,593903,588
,750910,778826,4141001,120
,8001014,854927,7381111,764
,8501136,1671043,5331243,043
,9001288,8071186,4771410,974
,9101325,6741220,6401451,897
,9201365,7251257,6221496,486
,9301409,7631298,1401545,658
,9401458,9471343,2331600,737
,9501515,0421394,4771663,738
,9601580,9461454,4651737,974
,9701661,9661527,9361829,513
,9801769,6691625,2151951,588
,9901939,4211777,8422144,689
a. A heterogeneity factor is used.
Relative Median Potency Estimates
(I) Waktu(J) Waktu95% Confidence Limits
EstimateLower BoundUpper Bound
PROBIT1254,307-59,296170,267
3138,61024,694258,679
4517,752384,663673,486
21-54,307-170,26759,296
384,303-28,964201,367
4463,445334,483612,695
32-84,303-201,36728,964
1-138,610-258,679-24,694
4379,142255,194519,582
42-463,445-612,695-334,483
1-517,752-673,486-384,663
3-379,142-519,582-255,194