Lecture 11Based on Chapter 17 -Regulation of Gene Expression in Bacteria and Bacteriophages
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2 – The lac Operon of E. coli
3 – Lactose as a carbon Source for E.coli
4 - Experimental Evidence for the Regulation of lac Genes
The experiments of Jacob and Monod produced an understanding of arrangement and control of the lac genes.
5 – Mutations in the Protein-Coding Genes
6 – Mutations affecting the Regulation of Gene Expression
7 – Operator Mutations
8 – lacI Gene Regulatory Mutations
9 – Jacob & Monod’s Operon Model for the Regulation of lac Genes
Figure 17.5
Figure 17.6
10 – Induction of lac by Allolactose (lactose)
11a – Effect of lac Oc Mutations (merodiploid)
11b – Effect of lac Oc Mutations (merodiploid)
12a – Effect of lacI- Mutations
12b – Effect of lacI- Mutations
12c – Effect of lacI- Mutations
13 – Additional lacI Mutations
14 – Positive control of the lac Operon
15 – Molecular Details of lac Operon Regulation
16 - The trp Operon of E. coli
17 – Molecular Model for Attenuation
18 – Molecular Model for Attenuation
19 – Genetic Evidence for Attenuation
20 – Attenuation at Other Operons
21 – The ara Operon of E. coli: Positive and Negative Control
22 – Regulation of Gene Expression in Phage Lambda
23 – Early Transcription Events
24 – The Lysogenic Pathway
25 – The Lytic Pathway