DOUBLE PROTECTION**

LEPTOSPIROSISHELP PROTECT YOUR CATTLE AGAINST BOTH UK STRAINS

PROTECTION MADE SIMPLE

Leptavoid®–Hcan be administered at the same time as your

Bovilis® BVDvaccine*

* To animals of 8 months of age or older

** For the active immunization of cattle from 1 month of age against Leptospira interrogans serovar hardjo (L. hardjo Prajitno) and Leptospira borgpetersenii serovar hardjo (L. hardjo Bovis). To reduce shedding of Leptospira interrogans serovar hardjo in urine. To improve herd fertility when infertility is diagnosed as caused by Leptospira hardjo.

HELP PROTECT YOUR CATTLE AGAINST BOTH UK STRAINS

UK OVERVIEW58% of dairy farms and 33% of beef farms tested positive for leptospirosis1.

In the UK, two strains of leptospirosis have been identified – Leptospira interrogans serovar hardjo and Leptospira borgpetersenii serovar hardjo 2.

If you don’t know the disease status of your farm then speak to your vet about the diagnostic tests available.

HELP PROTECT YOUR CATTLE AGAINST BOTH UK STRAINS

RISK TO YOUR CATTLEIn some cases the effects of leptospirosis can be dramatic, such as with a recent outbreak in Ayr where the herd experienced a sudden onset drop in milk production3.

In many cases, however, the underlying effects can go un-noticed but cause huge financial losses. In a study looking at 529 cows in 5 herds4:

» Conception to first service rate was significantly reduced in infected cows

» For a 100 cow herd* this could mean 18 less cows in calf

* For a 100 cow herd, optimum bull ratio/AI, over 3 breeding cycles (9 weeks)

46% 30%

60%

50%

40%

30%

20%

10%

0%Clean cows Infected cows

Conception to first service

HELP PROTECT YOUR CATTLE AGAINST BOTH UK STRAINS

RISK TO YOU AND YOUR STAFFCattle farmers are at particular risk of contracting leptospirosis5 from the urine of infected cattle, which may result in6:

» Protracted flu-like symptoms » Some cases – liver and kidney failure

HELP PROTECT YOUR CATTLE AGAINST BOTH UK STRAINS

VACCINATIONVaccination remains an important control measure and continues to be effective at reducing the incidence of clinical disease7 and the risk of infection:

» Infected herds

- Reduces urinary shedding and improves fertility

» Non-infected (naïve herds) - Prevents harmful effects if the disease entered the farm

HELP PROTECT YOUR CATTLE AGAINST BOTH UK STRAINS

* To animals of 8 months of age or older

LEPTAVOID®-H – LEADING THE WAYLeptavoid®-H is the UK’s leading leptospirosis vaccine8 and the ONLY one:

» Licensed to protect against BOTH UK strains - Leptospira interrogans serovar hardjo - Leptospira borgpetersenii serovar hardjo » Licensed to improve herd fertility where infertility is caused by L. hardjo: - 69% improvement in overall conception rate for infected farms9

» Approved to be given at the same time as a vaccine for BVD (at different injection sites)*: - Proven safety and efficacy of combination - Reduced cattle handling, improving on-farm efficiency

HELP PROTECT YOUR CATTLE AGAINST BOTH UK STRAINS

RISK FACTORS » Buying in stock with an unknown disease status

» Using a bull of unknown disease status

» Grazing near waterways

» Grazing with sheep

HELP PROTECT YOUR CATTLE AGAINST BOTH UK STRAINS

RECOMMENDED VACCINATION PROTOCOL WITH LEPTAVOID®-HIt is important your herd is fully protected against bovine leptospirosis before Spring turnout as, at grass, uninfected cattle are exposed to the urine of infected animals.

New vaccinators require 2 doses 4-6 weeks apart and the annual booster prior to turnout.

Natural service also spreads leptospirosis so remember to vaccinate the bull.

TURNOUT

1st DOSE6-8 weeks before turnout

2nd DOSE2 weeks before turnout

2 weeks before turnout

New vaccinators

Annual Boosters

Use medicines responsibly. For more information visit www.noah.uk/responsibleReferences:

1. BeefCheck and DairyCheck data, October 2013 – March 20152. Ellis, W.A. et al. (1998), Res Vet Sci, 44, p375-3793. 2015, Milk drop due to leptospirosis in dairy cows, Veterinary Record, 7

March, p247-2504. Williams, P. (1996), World Buiatrics5. Health and Safety Executive. (2015) Leptospirosis. [Online] Available

from: http://www.hse.gov.uk/agriculture/zoonoses-data-sheets/leptospirosis.pdf [accessed 16/11/15]

6. NHS Choices. (2015) Leptospirosis. [Online] Available from: http://www.nhs.uk/conditions/leptospirosis/pages/introduction.aspx

7. UK Zoonoses Annual Report. (2014). Non Statutory Zoonoses Annual Report [Online], available from: https://www.gov.uk/government/publications/non-statutory-zoonoses-disease-surveillance-reports-2014 [accessed 16/11/15]

8. GfK data, MAT August 2015 9. Dhaliwal et al. (1996), Vet Record, 138, p334-335

Leptavoid®-H is a vaccine containing Leptospira interrogans serovar hardjo 204 (inactivated). Legal category: POM-VPS . Contact your veterinary surgeon or animal health professional for further information and advice.Bovilis® BVD is a vaccine containing BVD virus strain C86. Legal category: POM-V . Bovilis BVD is only available via your veterinary surgeon from whom advice should be sought. For information regarding side effects, precautions, warnings and contra-indications please refer to the datasheet at www.noahcompendium.co.uk.Leptavoid-H and Bovilis BVD are the property of Intervet International B.V. or affiliated companies or licensors and are protected by copyrights, trademark and other intellectual property laws. Copyright © 2013 Intervet International B.V. All rights reserved.Further information is available from: MSD Animal Health Walton Manor, Walton, Milton Keynes MK7 7AJTel: 01908 685685 Fax: 01908 685555 Email: vet-support.uk@merck.com www.msd-animal-health.co.uk

UK leptospirosis vaccines:

LEPTAVOID®-H Vaccine S

Licensed to protect against both UK strains

Licensed to improve herd fertility

Developed from a UK isolate of L.hardjo

Can be given at the same time as Bovilis BVD

Proven reduced urinary shedding

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