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Leveraging Analytics to Change Opioid Prescribing BehaviorSession BP3, February 11, 2019
Mark Binstock, MD, MPH; CMIO Bon Secours Mercy Health
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Mark Binstock, MD, MPH
Has no real or apparent conflicts of interest to report.
Conflict of Interest
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• Analytics
• Prevention
• Screening
• Treatment
Agenda
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• Explore the key metrics for opioid prescribing• Confirm the central role of morphine equivalents in opioid
analytics• Review key provider facing tools to reduce inappropriate opioid
prescribing• Emphasize the contributions of People and Process to success
Learning Objectives
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‘Mercy Health earns HIMSS Davies Award for innovative approach to
opioid fight.’
“The Ohio health system implemented analytics and decision support to reduce opioid prescriptions.”
- HealthcareIT News
https://www.healthcareitnews.com/news/mercy-health-earns-himss-davies-award-innovative-approach-opioid-fight
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CDC National Guidelines: A Foundation for Our Build and Analytics
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https://www.cdc.gov/drugoverdose/prescribing/guideline.html
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Outpatient Opioid Prescribing Data Summary
-12%-16%
-30%
-15
-50%
-20%
Significant Reductions in Opioid Prescribing MetricsThe following opioid ordering behaviors were substantially reduced between December 2018 and December 2018:
Total Opioid Orders Opioid Orders to
All Medication Orders
Opioids Orders w/ MEDD > 80
Opioids w/ Day Supply > 7 days
Total MEDD per pt
Opioids Orders w/ MEDD >30 Acute Pain
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Morphine EquivalentsThe key to opioid analytics:
– Analogy of calories to food– Method of quantifying any opioid order
(prescription)– Morphine Equivalent Daily Dose (MEDD):
• Potency (conversion factor) X Dose (milligrams) X Frequency per day
– Can also be used at an order, patient, ordering provider, specialty, regional and population level:
• Potency X Dose X Dispense quantity
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Analytics Methodologies - Core Opioid Metrics• Total Opioid Orders: Raw count of narcotic orders within reporting period
• Auth Provider Outlier: Indicates that on any of the 3 Sentinel metrics the provider scores BELOW the 10th percentile
• Avg Percentile for 3 Sentinel Metrics: Mean of the Percentiles of the 3 Sentinel metrics
• Total MEQ RX: Cumulative morphine equivalent burden for all narcotics ordered within reporting period. gold standard takes into consideration potency, dose, frequency, and quantity dispensed
• Percentile Auth Provider Total MEQ RX: This represents the percentile score of the provider compared with peers with lower percentiles (in red shades) being associated with higher MEQ and higher percentiles (in green shades) associated with lower MEQ
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Analytics Methodologies - Core Opioid Metrics• Rate MEQD GT30 to Acute Opioid Orders: The proportion among narcotic
orders placed for acute pain episodes where the morphine equivalent daily dose exceeded 30
• Percentile Auth Provider Rate MEQD GT 30 to Acute Opioid Orders: Percentile score of the provider compared with peers with lower percentiles (in red shades) associated with higher MEQD >30 and higher percentiles (in green shades) associated with lower MEQD>30
• Rate MEQD GT 80 to opioid orders: Proportion of all narcotic orders where the morphine equivalent daily dose exceeded 80
• Percentile Auth Provider Rate MEQD GT 80 to Opioid Orders: Percentile score of the provider compared with peers with lower percentiles (in red shades) associated with higher MEQD>80 and higher percentiles (in green shades) associated with lower MEQD>80
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Two Opioid Key Performance Indicators for 20181) Morphine Equivalent daily dose limit for acute pain
prescriptions– Numerator: Number of total outpatient mode prescriptions where
morphine equivalent dose per day greater than 30
– Denominator: Acute outpatient opioid orders (in patients with no prior opiate prescriptions in the last 100 days)
2) Opiate Burden– Numerator: Total opiate burden (morphine equivalents)
– Denominator: Total unique patients with one or more selected encounters
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Region Baseline and Targets:• Two metrics:
1. Rate MEDD > 30 to Acute Opioid Orders2. Opioid Burden Rate
• 2018 targets are 90% of 2017 baseline
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Users Guide to Opiate Data Cube13
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Performance on Metrics by Region14
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MEDD>30 for Acute Prescriptions 15
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Opioid Burden 16
(Total MEDD for opioid prescriptions to number of unique patients)
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Rate Morphine Equivalents >30 (Opioid naïve patients, Ohio law 8.31.17)
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Opioid Burden: Total Morphine equivalent divided by patient
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2018 Opioid Prescribing Metrics by Month
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*Red box = Two strategic initiatives
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Provider Dashboard (Over time with drill down to orders)
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Provider-level Graphs21
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Medication Assisted Therapy (MAT)22
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Prevention: Provider-Facing Tools to Reduce Opioid Prescribing
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State Level Responses to the Opioid Crisis
• August 31, 2017 (Ohio)
– “7/5/30”• No more than 7 days of opioids can be prescribed for adults and 5 days of opioids can be
prescribed for minors & only after the written consent of parent/guardian
• The total MEDD of a prescription for acute pain cannot exceed 30
• Rules apply to the first opioid analgesic prescription for the treatment of an episode of acute pain
• November 15, 2017 (Kentucky)
– Limit of 3 day supply on C-II for acute pain
• December 29, 2017 (Ohio)
– Require diagnosis association on all opioid prescriptions
– Require indication of days supply on all controlled substance and gabapentin prescriptions
• June 1, 2018 (Ohio)
– Require diagnosis association on all controlled substances
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Preference List CustomizationCreation via import of opioid specific facility preference list containing fully configured compliant orders for selected common acute opioids.
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Preference List CustomizationProviders can use either fully configured orders or select a less configured choice.
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In-Line MEDD Calculation• All opioid containing medications possess a visual indicator of the calculated
MEDD within the order composer• Dynamically calculates based on order dose and frequency
– Does not calculate with free-text sigs
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MEDD Calculation
Calculated Morphine Equivalent Daily Dose (MEDD)• Have added a hyperlink in the upper right corner of our
Prescription Monitoring navigator section• Cannot calculate with free-text sigs
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Day Supply Limitations
Day Supply Designation• Hard Stop• Number of days will be dynamically
appended to sig when using discrete sigs (default)
• Issue: Long-term meds, PRN frequency, dispense qty, and duration may not always align
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30 Order Validation Alerts: MEDD
Threshold of 80 MEDD c
cThreshold of 30 MEDD
Order Validations fire at the END of the ordering workflow• Content ONLY – provides stage directions for what is
suggested but no follow up actions via the popup• If providers select “Accept” the order is placed
***Both MEDD and Days Supply can fire simultaneously
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31Order Validation: Days Supply
Ohio Adolescent: Days Supply = 5
Kentucky Patient: Days Supply = 3
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Ohio Adult: Days Supply = 7 c
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32 Unsigned Order BPA: MEDD
Threshold of 80 MEDD c cThreshold of 30 MEDD
Unsigned Order BPA fires at the BEGINNING of the ordering workflow.
• It provides follow up actions such as removing orders, placing Naloxone prescription, and links to document flowsheet values.
• If providers select “Accept” the order is NOT placed
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33Unsigned Order BPA: Days Supply
Ohio Adolescent: Days Supply = 5
Kentucky Patient: Days Supply = 3
c
Ohio Adult: Days Supply = 7 c
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Controlled Substance Monitoring SmartForm, Phase IAs a result of 2015 Ohio legislation, a SmartForm was implemented into Mercy’s EHR for quick documentation that could be utilized for reports.• Provided attestation button to document within the EMR that the PDMP report was reviewed -
a compliance requirement from PDMP• Any documentation within the form could be pulled into the providers note via a SmartPhrase• Provided a hyperlink out to the PDMP website to perform a manual query
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Controlled Substance Monitoring SmartForm Phase II: New Limits on Prescription Opioids• Effective August 31, 2017, Ohio passed new limits for prescribing opioids for acute pain• SmartForm versatility allows additional documentation to the SmartForm already in use• With provider guidance, the SmartForm was expanded to accommodate documenting the
new limits and exceptions on prescription opioids
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Controlled Substance Monitoring SmartForm Phase III: Appriss Integration
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1. Link to Integration and SmartForm.
2. Prior recorded SmartForm Values
3. MEDD Equivalent Daily Dose Calculations
4. Urine Drug Screenings
5. Scanned Med Contracts
6. Flags related to FYI flags
7. Links to PDMP websites
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Phase III: NarxCare Report
• The NarxCare report is the report display from Appriss
– Takes the raw controlled substance data received from multiple state pharmacies and creates scores and graphs
– Providers can quickly tell the patient's history with opioids and likelihood for abuse
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Issue: Free Text Sigs
Solution: Require discrete sig for opioids
• Over 104,600 free text orders in early 2 years window
• Most can be accommodated directly with discrete frequency
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Issue: Free Text Sigs
Solution: Dose and Frequency Range Education• Many providers were
unaware of ability to use range doses on outpatient prescriptions
• Created four new discrete frequency range choices:
– Q3-4H PRN– Q4-6H PRN– Q6-8H PRN– Q8-12H PRN
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• Add additional information to patient sig
– 140 total sig character limit
• Note to pharmacy – 300 hard character limit
Issue: Free Text Sigs
Solution: Education of Conveying Information to Pharmacy
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Concomitant Benzodiazepine & Opioid Prescribing Highest Risk for Overdose and Death
• Actionable CDS for Concomitant Benzodiazepine & Opioid Prescribing
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Concomitant Benzo/Opioids: Analytics
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Pain Agreement Status in Order Composer
• Per CMS, starting in 2019, Pain Agreements will expire for an existing controlled substance after 6 months.
• When ordering a controlled substance, the pain agreement status will display in the order composer.
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Release Note 635758
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Opioid Speed Buttons—Default of 3 Days
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PDMP Review Information Available on Radar Dashboards
• Help track individual & organization compliance with state regulations from prescription drug monitoring programs.
• Show % of opioid prescriptions where providers didn't review PDMP information in the same encounter.
Release Note 643819
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Appendix
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• Gary Grazak, Integration Engineer• Jedediah Tuten, Director Pharmacy,
Acute Operations• Nicholas Waggamon, Application
Coordinator, Willow Pharmacist• Karen Goda, Application
Coordinator, Ambulatory• Anna Lendl, Application
Coordinator, Ambulatory• Michael Temple, Manager
CarePATH, Research Informatics• Marcus Hanna, Executive Director,
Emergency Services
Key Contributors48
• Lisa Dubois, Application Coordinator, Interfaces
• Matt Rasmussen, Integration Engineer II, Cloverleaf
• Steve LeMaster, Application Coordinator, Interfaces
• Wayne Bohenek, Vice President, Care Transformation
• Brian Latham, Pharmacy Director, St. Rita’s Medical Center
• Rob Quigley, Vice President, CarePATH Ambulatory
• Kelley Recker, Vice President, CarePATH Operations
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Our Numbers:49
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Morphine Equivalents, cont.
Different opioids have different potencies, or Morphine Equivalents (MEs):
Hydrocodone = 1
Oxycodone = 1.5
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Opioid Prescribing – The Problem• There were 500,000 prescriptions a year out of CarePATH for
Vicodin 5-500/Norco 5-325
– Each pill contains 5mg hydrocodone = 5.0 MEs
– Typical every 4 hour dosing (6 pills/day) = 30 MEs/day
• There were 500,000 prescriptions a year out of CarePATH for Percocet 5 – 325
– Each pill contains 5mg oxycodone = 7.5 MEs
– Typical every 4 hour dosing (6 pills/day) = 45 MEs/day
These morphine equivalents were over the Ohio limit!
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Analytics Methodologies - Build• Key software used:
– SQL server 2014 – SQL Server Analysis Services 2016 RTM 1200 – Visual Studio DTS 2015 – Power BI v Oct 2015 – Excel 2016 with Power Pivot – SSIS
• Data sources used:– Epic (Clarity) – Explorys (IBM) – Kyruus – ACO Payors
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Acute Opioid
• Working definition: No preceding opioid order in a 100 day window prior to the incident opioid order.
– Measures not affected by erroneous or absent associated diagnoses or problem list entries.
• All of these metrics were built in a manner that is not dependent on the use of an Epic registry.
– They were set up in a way that was not dependent on, but could leverage Epic’s method of calculating and storing maximum morphine equivalent daily dose (MEDD)
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Diagnosis Requirement Association Order Validation
• Order Validation Point – Hard stop for diagnosis association– Lacks customization options
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• Order validation lacks ability to report on firing rate trends and ability to measure success of learned behavior
– Less alerts over time by way of providers associating upstream
• Created a robust tabular cube to monitor opioid prescribing overall allowed us to identify an issue where some opioid orders were not requiring diagnosis
– Data sharing moved Kentucky market to elect to participate in requirement
Diagnosis Requirement Association Order Validation
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Actionable Alert: Special Consent (Ohio HB 314)
• Clinical Decision Support (CDS) for special consent form for opioid prescribing to minors
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Strategies to Decrease Emergency Department Opioid Use
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Emergency Department Outpatient Opioid Prescription
Trend…
“Opioid-Free” Emergency Department Provider Outreach
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“Opioid-Free” Emergency Department: Community and Patient Outreach
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“Opioid-Free” Emergency Department60
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Emergency Department Outpatient Opioid Prescription Trend
Rate of Opioid Prescriptions to All PrescriptionsSpringfield Market
Year Patient Visits
VolumeReduction
2014 80,916 -
2015 77,945 3.8%
2016 71,696 8%
2017 65,976 8%
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Strategies to Decrease Inpatient Opioid Use
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Reducing Opioids in the Inpatient Setting
• As part of an organizational focus on decreasing overall numbers of opioid prescriptions, the following inpatient opportunities were identified:
– Presence of narcotic pain relief options on admission order sets not typically associated with pain
– Lack of a collection of Alternatives to Opioids (ALTO) options in one concise format for ease in ordering
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Designing a Solution:Removing Pain Medications from Select Order Sets
• In reviewing all admission and focused order sets with IV and oral pain medication, it was determined that over 30 were for treatment of diagnoses not normally associated with pain
– Validated with informatics committees and received nearly unanimous support for removal of these pain medications
– Standard biennial review cycle of all order sets still containing pain medications will be assessed for clinical appropriateness moving forward
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Designing a Solution:Creating a Pain Management Focused Order Set
• To supplement the removal of pain medications from many admission order sets and to provide a single location for opioid and non-opioid pain treatment a Pain Management Focused Order Set was created
• Plan to increase number of ALTO options after initial use period and evaluation in conjunction with system Pharmacy and Therapeutics Committee decisions
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Designing a Solution:Creating a Pain Management Focused Order Set• Key Features:
– Non-customizable– Set as a suggested order set for all admitted patients– In addition to traditional acetaminophen and ibuprofen, added
additional ALTO options– Provider has to navigate through non-opioid options to get to
opioid choices
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Designing a Solution:Creating a Pain Management Focused Order Set
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SBIRT:Screening, Brief Intervention, and Referral to Treatment
• Prior to SBIRT Implementation:• Alcohol, drug, and depression screenings were inconsistent• Alcohol and drug use screenings were outdated and not
linked to action• Approach to screening was inconsistent with public health
approach• There were no outcomes captured for patients’ drug or
alcohol use
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Screenshots: Prescreens
*All patients are asked the prescreen questions at triage
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SBIRT Screening Numbers (2016 - Q1 2018)
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10000
20000
30000
40000
50000
60000
70000
80000
2016 2017 2018Q1 Q2 Q3 Q4 YEARLY TOTAL
**The large, sustained spike in screenings beginning in Q2 2017 is due to the spread of SBIRT to several additional sites at that time. Additional sites were added in Q1 2018, resulting in another large spike in screenings.
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SBIRT Outcomes - ROI
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Alcohol Use Illegal Drug Use
Num
ber o
f Day
s (la
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Change in Substance Use for Mercy Patients 6 months post SBIRT screening protocol (n=155)
BaselineFollow-up
The chart illustrates change in number of days of substance use for Mercy patients with both a baseline and follow-up interview (n=155). Mercy patients demonstrated statistically significant reductions in alcohol (p=.002) and illegal drug use (p=.001). Data was collected from December 2015-August 2017
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Focused Order SetClinical Opiate Withdrawal Scale (COWS)
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Background
• Over the past few years, Mercy Health faced the rising tide of the opioid crisis
• Amid the increasing numbers of opioid-related overdoses and deaths, a growing number of patients with an opioid use disorder were presenting at Mercy inpatient facilities
• There were few evidence-based, standardized tools to help guide their treatment, and any existing tools were not integrated into the EMR
• Lack of ability to manage the symptoms of these patients while admitted to our facilities complicated care
– Increased burden of care on staff– Increased number of patients unable to complete necessary treatment
for co-morbidities
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Order Set Key Features
• Presence of buprenorphine– Required approval by Mercy Health Formulary Committee for use in
order sets– Limited to 72 hour duration to make available to physicians without
special prescribing authority to exceed 72 hours
• Combination of clonidine as adjunctive medication in linked panel with both buprenorphine and tramadol as treatment options
• Fixed dose strategy– COWS score dictated frequency of reassessment and follow-up doses– Avoided confusion of titrating various doses of medication
• Availability of medications for symptom management
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Opiate Withdrawal Focused Order Set74
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Designing a Solution:Clinical Opiate Withdrawal Scale (COWS)
• Nursing assessment that evaluates 11 signs/symptoms
• Stratifies severity of opiate withdrawal
• Flowsheet built to auto-calculate score
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Outpatient Opioid Prescribing Data Summary
-12%-16%
-30%
-15
-50%
-20%
Significant Reductions in Opioid Prescribing MetricsThe following opioid ordering behaviors were substantially reduced between December 2018 and December 2018:
Total Opioid Orders Opioid Orders to
All Medication Orders
Opioids Orders w/ MEDD > 80
Opioids w/ Day Supply > 7 days
Total MEDD per pt
Opioids Orders w/ MEDD >30 Acute Pain
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Success Stories77