LisaHelblingChadwick,PhD
Na6onalIns6tuteofEnvironmentalHealthSciences
ProgramDirector,4DNucleome
Epigenome(2005-2015)
Genome(1990-2005)
Ajourneyfromgenometonucleome
Epigenome(2005-2015)
Genome(1990-2005)
Ajourneyfromgenometonucleome
4DNucleome(2015-2020)
The4DNucleomeProgramseekstoadvanceunderstandingof:
• Theprinciplesunderlyingnuclearorganiza3onofmammaliangenomesinspaceand3me
• Therolethatnuclearorganiza3onplaysingeneexpressionandcellularfunc3on
• Howchangesinnuclearorganiza3onaffectnormaldevelopmentanddisease
Expecteddeliverables• Nextgenera6ontoolstoexploretherela>onshipbetweengenome
organiza>onandfunc>on–bothmoleculartoolsandimagingtools
• Referencemapsofthe3Dorganiza>onofthegenomeinavarietyofhumancells/>ssuesandcellstates.
• Developmentofcommunitystandardsandmetrics• Greaterunderstandingofpoorly-characterizednuclearstructures
andnuclearbodies:roleingenomeorganiza>on&func>on.
• Approachestointegratemolecularinforma6onwithimaginginforma6on
From:DarrowEMetal.,
PNAS2016
BuildingtheNetwork
Grantsawardedinsummer2015
Technologydevelopmentanddataproduc>ontounderstand3Dstructure/func>onrela>onships
Developmentoftoolsandtechnologiestoinves>gatethestructureandfunc>on
ofnuclearbodies/domains
Developmentandvalida>onofnoveltechnologiestoinves>gate
thethree-dimensionalorganiza>onofthegenome
Developmentandvalida>onofnovelimagingtechnologiesforvisualizingthestructureandfunc>onofthegenome,andhowitchanges
Data/metadatacollec>on,cura>on,anddissemina>on
Programcoordina>on,outreach,opportunity
funds
www.4dnucleome.org
www.4dnucleome.org
Applica6onsdueJanuary27,2017!
Transforma6veCollabora6veProjectAward
4DNWorkingGroupMembersCo-chairs:RodericPeTgrew,MD,PhD NIBIBDinahS.Singer,PhD NCIPhilSmith,PhD NIDDK
WorkingGroupCoordinators:OlivierBlondel,PhD NIDDKRichardConroy,PhD NIBIBJudyMietz,PhD NCI
CommonFundProgramLeaders:AnandaRoy,PhD OSC
4DNProgramDirector:LisaHelblingChadwick,PhD NIEHS
4DNProgramAnalyst:IddilBekirov,PhD NIDDK
WorkingGroup:DavidBalasundaram,PhD CSRTerryBishop,PhD NIDDKAnthonyCarter,PhD NIGMSSeanHanlon,PhD NCIRebeccaLenzi,PhD OSCMikePazin,PhD NHGRILisaPostow,PhD NHLBIMa]Reilly,PhD NIAAARobertRiddle,PhD NINDSJohnSa]erlee,PhD NIDAGeethaSenthil,PhD NIMHJessicaSmith,PhD OSCJoseM.Velazquez,PhD NIA