Long Term Memory• Function = organizes and stores info. More passive form of storage than
working memory• Capacity = unlimited. Average adult = 100 billion neurons, each of which
can make perhaps 5,000 to 10,000 synaptic connections with other neurons five hundred trillion to a thousand trillion synapses
• Duration = thought be some to be permanent
Long-term memory
Working orShort-term
Memory
Sensory
Input
Sensory Memory
Attention Encoding
Retrieval
Maintenance Rehearsal
History Channel: The Brain• Start at scene 12 or 58:00 of DVD 71• What is the function of memory?• Describe Lashly’s rat maze experiment in the 1920s. What
did he discover?• What is the capacity of long-term memory? • Who is Stephen Wiltshire? What is unique about his
memory? How is his brain different from a “normal” brain? • Who is Clive Wearing? What type of memory loss does he
suffer from and why? How has he changed over time? Why?
SemanticFacts/General
Knowledge
EpisodicExperienced
events
ProceduralSkills
Motor/Cognitive
Classical Conditioning
Explicit (Declarative)knowing you know something
conscious recall
Implicit (Non-declarative)knowing how to do something
(but not know you know)without conscious recall
Types of Long-Term Memory
Medial Temporal Lobe / Hippocampus / Frontal Lobe
Cerebellum
http://ngm.nationalgeographic.com/2007/11/memory/brain-interactive
Memory Loss• Anterograde amnesia – means forward; can’t form new memories.
– Effects of the accident are working forward in time and patient is unable to remember things that have happened since the accident
• Retrograde amnesia – means backward; can’t remember old memories . • Hit by a car at noon on Tuesday. Patient regained consciousness
Tuesday night and it is now Wednesday. Patient can’t remember the accident or anything that happened Tuesday morning before the accident.
Famous Amnesic Patients• EP – herpes simplex virus chewed its way though his brain, destroying his medial temporal
lobe (which contains hippocampus and amygdala)• HM – surgery destroyed hippocampus to stop epileptic seizures
– Surgery was effective in reducing seizures BUT, had other side effects as well– Can remember explicit memories acquired before the surgery
• e.g., old addresses, normal vocabulary – Cannot form NEW explicit memories
• e.g., remembering the name of someone he met 30 minutes prior• cannot name new world leaders or performers• can recognize a picture of himself from before his surgery but not from after and
doesn’t recognize himself in a mirror• Clive Wearing - renowned European conductor; viral encephalitis (inflammation of the brain
tissue) destroyed his hippocampus. – While brain damage has totally obliterated Clive's explicit memory--his ability to
remember new facts or events--his implicit memory remains intact; he still has language and musical skills, although he is not consciously aware of his ability to play music.
• All suffer deficits in explicit, but not implicit memory• All suffer from anterograde and retrograde amnesia
Explicit Memory Memories are those of which
one is consciously aware. EX: I may have an explicit memory of playing a particular golf course
1. Episodic = memories are those for personally experienced events
2. Semantic = memories are for general factual knowledge
Medial Temporal Lobe Hippocampus (left – trouble
remembering verbal info / right – trouble recalling visual designs and locations)
Frontal Lobe
Implicit Memory
Memories are those of which one is not conscious. EX: one may have implicit memories of how to tie one’s shoe but not be able to describe to another how to do it1. Procedural = memories are those
that relate to skills or habits. Learn how to do something, often through classical conditioning, but cannot know or declare they know.
2. Classical Conditioning Cerebellum
Synaptic Changes
• Release more serotonin at certain synapses when learning occurs
• Glutamate enhances long-term potentiation = an increase in the release of neurotransmitters or increase in receptors sites on receiving neuron. Rapidly stimulating memory-circuit connections causes those synapses to become more efficient at transmitting signals; takes less of a signal to recall a memory.
Review! Pieces of Mind: Remembering What Matters
• What is the role of adrenaline in the formation of memory? How do we know? Describe the experiments with the rats and people.
• What is the role of the amygdala in the formation of memory?
Stress Hormones and Memory Formation• Prolonged stress
disrupts LTP • Moderate stress
enhances LTP• When subjects are given
a beta blocker to stall the activation of the SNS, the experimental group did not remember the livelier story any better than the controls remembered theirs. The drug disrupts stress-enhanced memory formation and the experimental subjects did not get a boost in memory for the emotional section.
• Flashbulb Memories - Where you when????
Emotion Charged Event
Sympathetic Nervous System releases epinephrine
(adrenaline) and norepinephrine (noradrenaline)
Amygdala
Hippocampus into a more alert, activated
state. Something important is happening…
Focus! Focus! Focus!
Memory Consolidation