Translation

Cytokine Production, Apoptosis, etc.

Apoptosis

NeuronalPolarity

Cytokine-inducedmRNA stability

TNF-α Biosynthesis

Growth FactorsInflammatory Cytokines

RTK IL-1R

GPCR

TGF-BType II

Receptor

Type IReceptor

Transcription

Stress: Osmotic Shockγ-radiationAnisomycin

TNTNFF--αα BiBiosyntosynthhesesiiss

RTK IL-1RType I

Receptoryp

GPCRGPCRpp

Stathmin Tau

MEK3/6

MK2/3

HSP27PRAK

PYK2

Tao1/2 PKC

DAG

PLC

TAB1TTAK1

TRAF6

ESCIT

1R

IRAK

MEKK1–4

RacCdc42Ras

SOSGrb2ShcDAXXTRAF2TRAF2

TRADD

ASK1

MLKs

MEK4

eEF2K

MNK1/2

PLA2

Gα0

IL-1

p38 MAPK

DADRIP

MK2/3

Ets-1NFAT

Sap1Stat1

MaxMyc ELK1 p53

CHOPMEF2

ATF-2CREBMSK1

HMG-14HistoneH3

p38 MAPK

P

P

P

P

P

P

P

P

P P

P P

P

PPP

P

P

P

P

P

P

P

P

P

P

P

P P

P P

P

PPP

P

PP

MNMNP

P

P

P

P

P

P P P

P

P

P

P

P

PP

PP

P

P

P

MP M

P

EP P

P

P

2P

P

P

14P

P

P

P PP P

Key

Kinase

Phosphatase

TranscriptionFactor

Ligand

Discover more at abcam.com/mapk-p38

MAPK-p38 pathway

Copyright © 2013 Abcam. All Rights Reserved.Discover more at abcam.com/mapk-p38

Immunohistochemical analysis of paraffin-embedded human colonic adenocarcinoma tissue using ab32072.

c-Myc antibody [Y69] (ab32072)4 star reviews: Excellent

c-Myc participates in the regulation of gene transcription. It binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’, and it seems to activate the transcription of growth-related genes.

ClonalityM

ApplicationICC/IF, IHC-P, IP, WB

HostRb

Species reactivityHu, Ms, Rt

Antibody Clonality Application Host Species reactivity Product code

ASK1 antibody [EP553Y] M Flow Cyt, ICC/IF, IHC-P, WB Rb Hu, Ms ab45178Daxx antibody [E94] M Flow Cyt, ICC/IF, IHC-P, WB Rb Hu ab32140EEF2K antibody [EP881Y] M ICC/IF, IP, WB Rb Hu, Ms, Rt ab45168GRB2 antibody [Y237] M ICC/IF, IHC-P, IP, WB Rb Hu, Ms, Rt ab32037Hsp27 antibody [EPR5477] M Flow Cyt, IHC-P, IP, WB Rb Hu, Ms, Rt ab109376IRAKM antibody [Y278] M IP, WB Rb Hu ab32394MAPKAP Kinase 2 antibody [E341] M IP, WB Rb Hu, Ms, Rt ab32567MEK4 antibody [EP559Y] M ICC/IF, IHC-P, IP, WB Rb Hu ab33904

MEKK2 antibody [EP626Y] M Flow Cyt, ICC/IF, IHC-Fr, IHC-P, IP, WB Rb Hu, Ms, Rt ab33918

MEKK3 antibody [EP599Y] M Flow Cyt, ICC/IF, IHC-P, IP, WB Rb Hu, Ms, Rt ab40750MLK3 antibody [EP1460Y] - Carboxyterminal end M Flow Cyt, ICC/IF, WB Rb Hu, Ms ab51068MNK1 (phospho T385) antibody [EPR2370] M ICC/IF, IHC-P, WB Rb Hu ab109102p38 antibody [Y122] M ICC/IF, IHC-P, WB Rb Hu, Ms, Rt ab32142

PKC alpha antibody [Y124] M Flow Cyt, ICC/IF. IHC-Fr, IHC-P, IP, WB Rb Hu, Ms, Rt ab32376

PYK2 antibody [YE353] M ICC/IF. IHC-P, IP, WB Rb Hu, Ms, Rt ab32571Ras antibody [EP1125Y] M Flow Cyt, IP, WB Rb Hu, Ms, Rt ab52939RIP2 antibody [EPR4224(2)] M WB Rb Hu, Ms, Rt ab108971SHC antibody [EP332Y] M Flow Cyt, IP, WB Rb Hu, Ms, Rt ab33770SOS1 antibody [EPR7480] M ICC/IF, IHC-P, WB Rb Hu, Ms, Rt ab140621Stathmin 1 antibody [EP1573Y] M Flow Cyt, ICC/IF, IHC-P, IP, WB Rb Hu, Ms, Rt ab52630Tau antibody [E178] M ICC/IF, IHC-P, IP, WB Rb Hu, Ms, Rt ab32057TRAF6 antibody [EP591Y] M Flow Cyt, IHC-P, IP, WB Rb Hu, Ms, Rt ab33915

Related antibodies

Key: Hu - Human, Ms - Mouse, Rb - Rabbit, Rt - Rat

Substance Description Product code

PD 98059 MEK1 inhibitor ab120234Phorbol 12-myristate 13-acetate (PMA) PKC activator ab120297

SB 203580 hydrochloride p38 MAP kinase inhibitor; water soluble ab120235

SL 327 MEK inhibitor ab120082U0126 Selective MKK inhibitor ab120241

Related biochemicals

Related ELISA kitsELISA kit Tests Species reactivity Product code

Ras GTPase ELISA Kit (Chemiluminescent) 1 x 96 well plate Hu, Ms ab134640Mek1 (pS217/221) ELISA Kit 1 x 96 well plate Hu, Ms, Rt ab126446Hsp 27 Human ELISA Kit 1 x 96 well plate Hu ab108862PhosphoTracer p38 MAPKα pThr180/Tyr182 + Total ELISA Kit 1 x 96 well plate Hu, Ms ab119665

PhosphoTracer p53 pSer15 + Total ELISA Kit 1 x 96 well plate Hu ab119666

EX

T_006_13

Product

highlights

MAPK-p38 pathway

- Rabbit Monoclonal Antibodies (RabMAbs)