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March 15 and 16, 2018 NCI Shady Grove Rockville, MDTargeting DNA damage repair in small cell lung...

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March 15 and 16, 2018 NCI Shady Grove Rockville, MD
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Page 1: March 15 and 16, 2018 NCI Shady Grove Rockville, MDTargeting DNA damage repair in small cell lung cancer and the biomarker landscape Triparna Seri, Carl Gay, Lauren Averett Byers Current

March 15 and 16, 2018 NCI Shady Grove

Rockville, MD

Page 2: March 15 and 16, 2018 NCI Shady Grove Rockville, MDTargeting DNA damage repair in small cell lung cancer and the biomarker landscape Triparna Seri, Carl Gay, Lauren Averett Byers Current
Page 3: March 15 and 16, 2018 NCI Shady Grove Rockville, MDTargeting DNA damage repair in small cell lung cancer and the biomarker landscape Triparna Seri, Carl Gay, Lauren Averett Byers Current
Page 4: March 15 and 16, 2018 NCI Shady Grove Rockville, MDTargeting DNA damage repair in small cell lung cancer and the biomarker landscape Triparna Seri, Carl Gay, Lauren Averett Byers Current

What Brought Us Here?

Page 5: March 15 and 16, 2018 NCI Shady Grove Rockville, MDTargeting DNA damage repair in small cell lung cancer and the biomarker landscape Triparna Seri, Carl Gay, Lauren Averett Byers Current
Page 6: March 15 and 16, 2018 NCI Shady Grove Rockville, MDTargeting DNA damage repair in small cell lung cancer and the biomarker landscape Triparna Seri, Carl Gay, Lauren Averett Byers Current
Page 7: March 15 and 16, 2018 NCI Shady Grove Rockville, MDTargeting DNA damage repair in small cell lung cancer and the biomarker landscape Triparna Seri, Carl Gay, Lauren Averett Byers Current
Page 8: March 15 and 16, 2018 NCI Shady Grove Rockville, MDTargeting DNA damage repair in small cell lung cancer and the biomarker landscape Triparna Seri, Carl Gay, Lauren Averett Byers Current
Page 9: March 15 and 16, 2018 NCI Shady Grove Rockville, MDTargeting DNA damage repair in small cell lung cancer and the biomarker landscape Triparna Seri, Carl Gay, Lauren Averett Byers Current
Page 10: March 15 and 16, 2018 NCI Shady Grove Rockville, MDTargeting DNA damage repair in small cell lung cancer and the biomarker landscape Triparna Seri, Carl Gay, Lauren Averett Byers Current
Page 11: March 15 and 16, 2018 NCI Shady Grove Rockville, MDTargeting DNA damage repair in small cell lung cancer and the biomarker landscape Triparna Seri, Carl Gay, Lauren Averett Byers Current
Page 12: March 15 and 16, 2018 NCI Shady Grove Rockville, MDTargeting DNA damage repair in small cell lung cancer and the biomarker landscape Triparna Seri, Carl Gay, Lauren Averett Byers Current
Page 13: March 15 and 16, 2018 NCI Shady Grove Rockville, MDTargeting DNA damage repair in small cell lung cancer and the biomarker landscape Triparna Seri, Carl Gay, Lauren Averett Byers Current

Bibliometric Analysis by NIH iTrans

Page 14: March 15 and 16, 2018 NCI Shady Grove Rockville, MDTargeting DNA damage repair in small cell lung cancer and the biomarker landscape Triparna Seri, Carl Gay, Lauren Averett Byers Current

Bibliometric Analysis by NIH iTrans

1995-2004 2005-20141995-2018

2015-2018

Page 15: March 15 and 16, 2018 NCI Shady Grove Rockville, MDTargeting DNA damage repair in small cell lung cancer and the biomarker landscape Triparna Seri, Carl Gay, Lauren Averett Byers Current
Page 16: March 15 and 16, 2018 NCI Shady Grove Rockville, MDTargeting DNA damage repair in small cell lung cancer and the biomarker landscape Triparna Seri, Carl Gay, Lauren Averett Byers Current

February 13, 2018 (iSearch)

Page 17: March 15 and 16, 2018 NCI Shady Grove Rockville, MDTargeting DNA damage repair in small cell lung cancer and the biomarker landscape Triparna Seri, Carl Gay, Lauren Averett Byers Current

March 13, 2018 (iSearch)

Page 18: March 15 and 16, 2018 NCI Shady Grove Rockville, MDTargeting DNA damage repair in small cell lung cancer and the biomarker landscape Triparna Seri, Carl Gay, Lauren Averett Byers Current

Goals of the SCLC Consortium Meeting• Updates on ongoing studies• Finding new opportunities for collaborations, new projects• Plans for utilization of resources provided by the Coordinating Center

and the NCI• Recognizing gaps in SCLC research

• 2013 Priorities:• Better Research Tools for the Study of SCLC • Comprehensive Genomic Profiling of SCLC • New Diagnostic Approaches for SCLC • Therapeutic Development Efforts • Mechanisms Underlying Both High Rate of Initial Response and Rapid

Emergence of Drug and Radiation Resistance

Page 19: March 15 and 16, 2018 NCI Shady Grove Rockville, MDTargeting DNA damage repair in small cell lung cancer and the biomarker landscape Triparna Seri, Carl Gay, Lauren Averett Byers Current

Clinical Trials in SCLCRecruiting and Not Yet Recruiting in 2018 (clinicaltrials.gov)

All Phase 1 Phase 2 Phase 3 Phase 4

159 56 84 20 2

All U24 U01 R21 R01 K99 K08 F31

18 1 7 2 5 1 1 1

NCI Grants in SCLCAwarded in 2017 (NIH IMPACII database)

Page 20: March 15 and 16, 2018 NCI Shady Grove Rockville, MDTargeting DNA damage repair in small cell lung cancer and the biomarker landscape Triparna Seri, Carl Gay, Lauren Averett Byers Current

Meeting Logistics

• Internet: NIH-Guest-Network• Cellphones on MUTE

• Speakers: please introduce your NCI project• Timing of presentations• Sharing slides?

• Cafeteria for lunch, closes at 2 pm• Buses to hotel at 6:15 pm• Tomorrow bus to NCI at 7:15 am• Sign-up for TAXI available at the registration desk


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