Microarrays, Genomics, Microarrays, Genomics, and Systems Biologyand Systems Biology
Keys to Science Institute – Molecular Keys to Science Institute – Molecular Biology and Biotechnology 2004Biology and Biotechnology 2004
Scientific DisciplinesScientific Disciplines
BiologyBiology Molecular BiologyMolecular Biology BiotechnologyBiotechnology BioinformaticsBioinformatics GenomicsGenomics Systems BiologySystems Biology
The Challenge over TimeThe Challenge over Time
Identify a single gene (related to Identify a single gene (related to disease)disease)
Identify as many, if not all, genes of Identify as many, if not all, genes of an organisman organism
Identify all sequence, including non-Identify all sequence, including non-coding regions, contained within a coding regions, contained within a genomegenome
Consider how the kinds of scientific Consider how the kinds of scientific questions to be asked change.questions to be asked change.
GCATGCAT
Genome Consortium for Active TeachGenome Consortium for Active Teachinging
Introduction to MicroarraysIntroduction to Microarrays AnimationAnimation
TIGR and CeleraTIGR and Celera
The Institute for Genomics Research The Institute for Genomics Research (TIGR) – non-profit, private(TIGR) – non-profit, private
July 1995, first whole genome July 1995, first whole genome sequenced – sequenced – Haemophilus influenzae Haemophilus influenzae 1.8Mb1.8Mb
Celera – for profit ventureCelera – for profit venture– celere celere is Latin for “swift”is Latin for “swift”– shotgun sequencingshotgun sequencing
All information gleaned from:All information gleaned from:
Campbell, A. Malcolm and Laurie J. Campbell, A. Malcolm and Laurie J. Heyer, “Discovering Genomics, Heyer, “Discovering Genomics, Proteomics, and Bioinformatics”, Proteomics, and Bioinformatics”, ISBN 0-8053-4722-4ISBN 0-8053-4722-4
Genome Consortium for Active Genome Consortium for Active Teaching (GCAT) websiteTeaching (GCAT) website
TIGR powerpoint presentationsTIGR powerpoint presentations TIGR websiteTIGR website
