Microsystems and pHealth - European Society of Cardiology · Mobile phone based platforms,...

EHRA Summit 2010 Sophia Antipolis FranceEHRA Summit 2010, Sophia Antipolis, France22-23 March 2010

Microsystems and pHealth:

Andreas LymberisResearch Program Officer

[email protected]

Information Society Technologies and Media, Micro-systemsEuropean Commission, Brussels

A. Lymberis, EHRA, Sophia Antipolis, France, 22-23 March 2010

LAYOUT

• Micro & Nano technologies for better life• Microsystems and Smart Systems Integration• Microsystems and Smart Systems Integration• MNBS (Micro-nano-bio convergence systems)

Mi f bl li d • Microsystems for wearable personalised applications

• Framework Program 7- Current activities and workprogram 2011-12



Technology transforms Medicinegy f

• To a significant extent the improvement in lifetime expectancy To a significant extent the improvement in lifetime expectancy can be attributed to Medical Technologies.

• 70% of the survival improvement in heart attack mortality can be attributed to changes in technology * e g introduction of the attributed to changes in technology e.g. introduction of the pacemaker and increasing use of minimally-invasive surgery enabled by advance medical imaging technologies.H t k bl d h i id d • Heart pacemakers, blood pressure sensors, hearing aids and cochlear implants and biochips: total revenue of $ 5,2 billion (2001) **

• Strong market demand for microsystems and nanotechnologies in medical applications continuous technological innovation

* D.M. Cutler and M. McClellan, Is Technological Change in Medicine Worth It?, Health Affairs 20, 11-29 (2001)**J. M. Wilkinson, “Medical Market for Microsystems,” International Newsletter on Microsystems and MEMS, No 4/02,

p. 37, September 2002.


Convergence of MicroNano- Bio-ICT and Therapies Optimisation

Progress in many therapeutic areas until now through effective drugs g y p g gtreatment, surgical intervention and use of implants devices.In reality diseases still growing as more chronic and often degenerative (e g multi-drug resistant infections chronic heart failure and pulmonary (e.g. multi-drug resistant infections, chronic heart failure and pulmonary diseases. Therapeutic solutions today are not optimal.

Diagnosis lacks of sensitivity and specificity and remains invasive in most of the cases.Pharmaceutical treatment has non-specific action and very often inadequate dosing and kinetics. Surgical intervention is overly invasive, lacks of precision and causes damage to tissues.Medical implants have relatively poor biocompatibility and connectivity with tissues, inadequate durability, clumsy power supply - size – weight, etc.


New concepts and integrated approaches and systemsapproaches and systems.

– Integration of diagnosis, treatment and monitoring– Computer-assisted, image based intervention– Drug-device combinations and targeted delivery of drugs

and genes– Sensor-activated (closed loop) drug delivery systems( p) g y y– Integrated neuronal interfaces and muscular stimulators

(epilepsy, appetite suppression, hemi- and quadriplegia, blind- and deafness…)blind and deafness…)

– Fast information about the patient’s response to the treatment is essential for its success (complex combination of IVD imaging and information technologies) of IVD, imaging and information technologies).

Micro- nano systems are potent facilitators of integration.


LAYOUT

• Micro & Nano technologies for better life• Microsystems and Smart Systems Integration• MNBS (Micro-nano-bio convergence systems)MNBS (Micro nano bio convergence systems)• Microsystems for wearable personalised

applications applications • Framework Program 7- Current activities and

k 2011 12workprogram 2011-12


What are Smart Systems?Smart Systems …intelligent miniaturised technical subsystems evolving from microsystems technology with ≥ 1 additional functionalities:

y

are able to diagnose a situation, describe it and qualify it,mutually address and identify each other, are predictive, p ,are able to decide and help to decide,enable the product to interact with the environment.

They are networked, energy autonomous and highly reliable.R&D in advanced microsystems driven by application

A. Lymberis, EHRA, Sophia Antipolis, France, 22-23 March 2010 ••• 8Smart implants Smart RFID Smart antenna Smart tire

High growth potential in a broad range of application sectorssectors

Everywhere(almost !)

• Biomedical• Transport

T l i ti ( )• Telecommunications• Automotive• Safety• Environment• Smart textiles• Conformable Flexible systems• Conformable, Flexible systems

World market• 2006: 32 Bn€ (only for Microsystem technologies)• 2011 prediction: 57 Bn€


Microsystems in FP6:Total budget [2002-2006]

Thematic areas covered

• Micro/Nano-bio ICT.

[2002 2006] 301M€

Micro/Nano bio ICT.Biosensors, lab-on-chip, DNA & protein analysis chips, food safety & quality monitoring, implants, drug delivery, medical imaging

• Sensor-based systems and Storage.Integrated sensor systems MEMS handling of nano objects mass storageIntegrated sensor systems, MEMS, handling of nano-objects, mass storage

• Organic/Large area electronics and Displays.Organic electronics, flexible electronic systems, flexible displays, large-area applicationspp

• Systems for Ambient Intelligence (AmI).Mobile phone based platforms, networked multisensors system for elderly people, smart textiles, biosensing textiles

• Manufacturing and Process integration• Manufacturing and Process integration.Microsystems manufacturing technologies from design to packaging testing and reliability

• Smart fabrics and interactive textile.f d d f b d l h f b lIntegration of advanced fibres and materials at the fibre core. E-textiles

• Support and coordination actions.Networking, roadmaps


EU Policies: The renewed Lisbon agenda

• Markets & Competition: Europe – A more attractive place to invest & workp p p– Extend & deepen the internal market – Improve European and national regulation– Ensure open & competitive markets inside & outside Europep p p– Expand & improve European infrastructure

• Knowledge & innovation for growth• Knowledge & innovation for growth– Increase & improve investment in R&D– Facilitate innovation & uptake of ICT & the sustainable use of resources– Contribute to a strong European industrial base– Contribute to a strong European industrial base

• Employment & Skills: Creating more & better jobsAtt t l i t l t & d i i l t ti t– Attract more people into employment & modernise social protection systems

– Improve the adaptability of workers & enterprises & the flexibility of labour marketsInvest more in human capital through better education & skills


– Invest more in human capital through better education & skills

LAYOUT

• Micro & Nano technologies for better life• Microsystems and Smart Systems Integration• MNBS (Micro-nano-bio convergence systems)( g y )• Microsystems for wearable personalised

applicationsapplications• Framework Program 7- Current activities

and workprogram 2011-12and workprogram 2011-12


New Generation Technology Opportunities at the gy ppConvergence of MicroNano- Bio-ICT

ICT

Highly InterdisciplinarySystem miniaturization

(wearability, implantability)High volume/low cost production

ICT

Next Generation Technology μ chip

Biotechnology

Micro-Nano Technology

Technology Opportunities

New or increased functionality

(DNA t i ll

μ-chip

(DNA, protein, cell detection)

Medical research& Unprecedented

possibilities


MNBS group of FP6 Projects: Structure, links and content

Sample preparation

MicroFluidicsDNA-protein

t ti

Biocompatible materials

MN Fabrication

Biosensor-based MNS MNS interfacing with human body

extraction-detection

BiomarkersSensors-actuators

human bodyProjects

ProjectsBiorobotics functions

Surface functionalisation, immobilisation

Power, Signal Processing, Telecoms, Packaging, Manufacturing, Standardization, Ethics, Testing Validation Business IPR Certification Dissemination Awareness Education

Common Aspects

Testing-Validation, Business, IPR, Certification, Dissemination, Awareness, Education.

36 Projects, 2 Service Actions 110 M€, 390 Organisations, 27 MS & AS + China, Australia, USA, Korea, Mexico60 Universities, 50 R&D Centers & Institutes, 70 companies (Research & product evelopment)


60 Universities, 50 R&D Centers & Institutes, 70 companies (Research & product evelopment)

Healthy Aims Nanoscale materials and sensors and microsystems for medical implants improving health & quality of life

Glaucoma SensorIntracranial

Pressure Sensor

Gyro

–

Retina Implant

Gyro

Retina Implant

Cochlear Implant

IMU for Human Body Motion

Accelerometer

Artificial Intra-Urethral Functional Electrical Sti l ti


Sphincter Stimulation

Versatile endoscopic capsule for gastrointestinal tumour recognition and therapy (VECTOR)

Multifunctional microprobe arrays for cerebral applications (NEUROPROBES)


In vitro molecular diagnostics

-Lab-on-chip based protein profiling for Cancer profiling for Cancer diagnostics- Cell-On-Chip biosensor for detection of cell-to-cell interactions- Integrated Microsystem for magnetic isolation and magnetic isolation and analysis of Single circulating tumour cells for oncology- Deep Vein Thrombosis –Deep Vein Thrombosis Impedimetric microanalysis Systems -Food safety and Quality Food safety and Quality monitoring with Microsystems


Nanobiotechnology Markets: Europe should gy pbecome more competitive

350 500 $billi i ll d h l h d h i l • 350-500 $billion is allocated to healthcare and pharmaceutical applications

• Nanobiotechnology market: $4b (2002), $8b (2005), $20b (2010), $70b (2015)

• Gap between USA and EU: In 2005, $8b (5.1 USA, 1.5 EU); in 2010, $20b (12 USA, 4 EU); in 2010, $ 70b (35 USA, 21 EU)(12 USA, 4 EU); in 2010, $ 70b (35 USA, 21 EU)

• VERY WELL IN TERMS OF FUNDING, BUT ...

- could do better in publications, patents, uptake

- About 20% of ISI publications (the US produces about 40%)

- Less than 20% of Nature and Science publications (the US produces 50%)

D l i i li ti f t h l i- Delay in commercialisation of technologies


Nanobiotechnology: A Jain Pharmabiotech Report

Factors that hinder or Delay execution (worldwide)

l d• Knowledge gaps (e.g. biochemical pathways)• Technology gaps (MNB at early stage, integration of

building blocks, power management, etc)

• Reliability (complex and emotive)

• Liability issues (much beyond technology development and application)

• Cost and affordability!• User issues-ethicsUser issues ethics


LAYOUT

• Micro & Nano technologies for better life• Microsystems and Smart Systems Integration• MNBS (Micro-nano-bio convergence systems)• Microsystems for wearable personalised Microsystems for wearable personalised

applications• Framework Program 7- Current activities and a ewo og a Cu e t act v t es a d

workprogram 2011-12


Non-invasive measurements: Plethora of possibilities

Audiogram,

Analysis of the voice E.E.G, M.E.G., R.M.N.

Breath: volume, pressure, VO2, VCO2…...Breath: volume, pressure, VO2, VCO2…...

Pulmonary sound Cardiac sound

Vascular blood flowDoppler Ultra Sound

E.C.G.

Mucles sound

Arterial pressure

Breath: Frequency, Amplitude, Flow,...

Skin: Temperature Resistance

Emotional responseVigilance, Mental charge Skin: Temperature, Resistance,

Impedance, Blood FlowHydratation, color,…Thermic & tactile sensitivity

g , g

E.M.G.Activity of muscles: Thermic & tactile sensitivity

Cardiac frequency & fetus movementmovement, speed, power


Forms of the body & dimensions(Optic, laser, Ultra sound, X-Ray)

Urinal flow

Courtesy A. Dittmar, Insa Lyon, Fr


Smart textile Prototypes


From Portable to Wearable: R&D prototypes (1990-2000)

M. OGAWA, T. TOGAWAPillow electrode

,Inst. for Biomaterials Bioengineering,

Tokyo Med University

Electrode contacting with the leg


Technology Push: Development & Integration of innovative sensing, MNT, textile and ICTg, ,

Micro-communicating: Microsystems physical sensors(attitude, fall, health, …)

sensor interface, processing and wireless

( , , , )

Flexible displaysFlexible displays

Nanoengineered surfaces Conductive fabricsConductive fabrics Micro-interfacesPoint of care

Micro-energy generators


Courtesy CSEM, CH

Smart FabricsSmart Fabrics--Interactive Textile and Flexible Wearable SystemsInteractive Textile and Flexible Wearable SystemsA l t f ECA l t f EC f d d P j t (f d d P j t ( h/ fith/ fit))A cluster of ECA cluster of EC--funded Projects (funded Projects (www.csem.ch/sfitwww.csem.ch/sfit))


R&D in Smart textiles: Achievements and Gaps

WEALTHY, 2005 ECG electrodes

2000 2005 20102000 2005

Towards full value chain development

Wearable sensors/

computing

•Developing & testing yarns as sensors and electrodes•Knitted integrated connections to measure resistance values in the same

-Innovative development and integration of sensing (bio, opto..) in patches, textile, garment.-Improvement of power

pi.e. R&D, manufacturing, standardisation, l d k tcomputing fabric

•Testing for several biophysical and mechanical parameters•Piezoresistive fabrics First

management for wearable applications - Development & testing & integration of polymer materials

lead markets


Piezoresistive fabrics First integrated prototypes

g p yfor active functions- Improved connectivity and short/long range communication

Prominent area of R&D. Need to address, l g ith f t h ll g ifi d along with future challenges, specific needs

Interlink between technologies and applications is vital for bothInterlink between technologies and applications is vital… for both

Various business models, with different integration levels, are emergingemerging

Additional requirements on flexibility, stretchability, conformability, favour developments on new materials (plastic) and new manufacturing processes (roll to roll)

Interdisciplinarity will open new opportunities by bringing closer together the li ing orld and ICTtogether the living world and ICT

Cost efficient, robust manufacturing technologies will succeed

Research excellence needs to be accompanied by education and technology access actions


LAYOUT

• Micro & Nano technologies for better life• Microsystems and Smart Systems Integrationy y g• MNBS (Micro-nano-bio convergence systems)• Microsystems for wearable personalised Microsystems for wearable personalised

applications • Framework Program 7- Current activities and Framework Program 7 Current activities and

workprogram 2011-12


FP7 [2006-2013] Specific ProgrammeFP7 [2006 2013] Specific Programme

“Cooperation”Collaborative R&D, pre-defined themes, JTIs

32413 EUR million

“Ideas”Frontier research, competition, individual grants

NEW 7510

65 %15 %“People”

Human potential, mobility

“C iti ”

15 %

9 %4750

8 %“Capacities”

Infrastructure, SMEs, science and society

Joint Research Centre (non-nuclear) Total1751

4097

+EURATOM

EURATOM Programme

( )50521 EUR million

2006-2013

2751


EURATOM Programme

FP7 Cooperation: ThemesFP7 Cooperation: Themes

Budget [EUR million]

1. Health 61002. Food, Agriculture & Biotechnology 19353. Information & Communication Technologies 90504. Nanosciences, Nanotechnologies,

Materials & new Production Technologies 34755. Energy 23506. Environment (including Climate Change) 18907. Transport (including Aeronautics) 41608. Socio-Economic Sciences & the Humanities 6239. Space 143010. Security 1400

Joint Technology Initiatives

ERA-Nets

32413

… including

A. Lymberis, EHRA, Sophia Antipolis, France, 22-23 March 2010 International Co-operation

g

FP7 Call 5, 31/7/2009 – 3/11/2009Objective Microsystems, 3.9

Budget “Instrument”

(a) Heterogeneous Integration

(b) Autonomous energy efficient smart systems

IP or STREP

STREP

(c) Application-specific Microsystems77 M€STREP

IP orIP or STREP

(d) Coordination and Support actions3 M€ CSA


Objective 3.9: Microsystems and Smart Miniaturised SystemsSystems

Coverage of retained proposals

Application-specific Microsystems (50 M€)

Microsystems and Smart Systems Technologies:

(Heterogeneous Integration and Autonomous Systems)

Telecommunications: 1

y )(27 M€): 7

Bio-med and bio-tech: 7Food/Beverage: 1

Smart Fabrics & Intractive textile: 1

Heart-e-Gel: system characterisation of electroactive gels and their behaviour in cardiovascular surgery: a generic occluder for vascular repair, a vascular occluder with expansion feedback sensing and a system for

Coordinated A ti (3 M€) 2

improving endografts for the treatment of abdominal aortic aneurysms.

A. Lymberis, EHRA, Sophia Antipolis, France, 22-23 March 2010 TOTAL8

0M€

Actions (3 M€)-2

2011-2012: MNBS

Where do we want to go and why?Increase or at least maintain the 35 % market share of

Target outcomes•We want to go to:

– Eliminate the current technical issues

– Increase the participation in food and environment

Increase or at least maintain the 35 % market share of the European Companies and its associated jobs:

– 2,3 b$ worldwide estimated market for 2012– 30 % estimated Compound Annual Growth

environment

– Increase the number of innovative in vivo applications

– Reduce the risk of “wasted” research

– 8500 European companies• Decrease the health care cost by:

– Predictive medicine and early diagnostic– Reducing stay in hospitals (minimal invasive due to post-project regulatory issues.

•Because we want to:– Open new markets sub-segment (and

don’t left them to US Japan and China)

– Reducing stay in hospitals (minimal invasive surgery, faster analysis……..)

– Better management of chronic disease..• Save live (less traumatic surgery, faster time to

d f f ddon t left them to US, Japan and China).

– To facilitate the transition from technology research to product development (risk reduction)

T E i i h

diagnostic in infection, faster response to cardiac and diabetes crisis,…...).

• Improve the quality of live of elderly and chronic patients

– To attract European companies with enough market and industrial capacity

• Facilitate the production of high quality food• Increase the environmental control


••• 34

Multidisciplinary teams of product designers and engineers with early input and feedback of health

f i l d dprofessionals and end-users.


THANK YOUf Att tifor your Attention

• European research on the web:– http://cordis.europa.eu/fp7/home_en.htmlp p p– http://ec.europa.eu/comm/research/future/

• Information Society and Media:– http://cordis.europa.eu/fp7/ict/programme/home_en.html

• Challenge ICT-2007.3.9:Microsystems and Smart Miniaturised Systems : http://cordis.europa.eu/fp7/ict/micro-nanosystems

• Challenge ICT-2007.3.2:Organic and large-area electronics, visualisation & display systems : http://cordis.europa.eu/fp7/ict/organic-elec-visual-display/home_en.html

Contact:[email protected]

The views expressed in this presentation are thepersonal views of the author and do not necessarily

reflect the official view of the European Commission onh bj


the subject matter.

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