Monthly prostaglandin bibliography prepared by the University of Sheffield Biomedical Information...

TWICE MONTHLY BIBLIOGRAPHY ON PROSTAGLANDINS BIOLOGY- EARLY SEPTEMBER PREPARED BY SHEFFIELD UNIVERSITY BIOMEDICAL INFORMATION SERVICE

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1. BOOKS, REVIEWS, SYMPOSIA Coniglio JG// Vanderbilt Univ, Dept Biochem, Nashville, Tn 37232, USA NUTR REV 1992,50 (7) 195 How does fish oil lower plasma triglycerides (Brief critical review)

Divemois C, Couffinhal T, Lemetayer P, Haissaguerre M, Warin JF// Hop St Andre, &IV Cardiol & Med Inteme, 1 Rue Jean Bur- guet, F-33075 Bordeaux, France ARCH MAL COEUR VAISSEAUX 1992, 8.5 (6) 899 Potential value of omega-3 polyunsaturated fatty acids in the prevention of athemscle- rosis and cardiovascular disease (Review)

Seyama Y// Univ Tokyo, Fat Med, Dept Physiol Chem & Nutr, 7-3-l Hongo, Bunkyo ku, Tokyo 113, Japan J FOOD HYG SOC JPN 1992,33 (3) 209 Platelet activating factor in diseases in relation to food and receptor (Review) (Japanese)

2. GENERAL Foreman D, Parker C, Alonzo I, Salomon RG// Case Western Res Univ, Dept Biol, Cleveland, Oh 44106, USA PROSTAGLANDINS 1992,43 (6) 573 Physiological evidence for the possible existence of anhydrolevuglandin-E2-like activity in extracts and media from uteri of rats.

3. PRECURSORS Tesfamariam 8. Cohen R4// Bristol Mvexs Squibb Res Inst, Dept Pharmacol, Box 200, Princeton, NJ 08543, USA AMER J PHYSIOL 1992,262 (6) Pt2, H1915 Role of superoxide anion and endothelium in vasoconstrictor action of prostaglandin en- dopemxide.

Jamaluddin M, Thomas A// Sree Chitra Tiru- nal lnst Med Sci & Technol, Thrombosis Res Unit, Thiruvananthapuram 695012, India J BIOSCIENCES 1992,17 (2) 129 Competitive inhibition of hydrogen peroxide- induced aggregation of calf platelets by prostaglandin H-2 thromboxane A2 receptor li- gands.

4. Arachidonic Acid Koyama K, Hirose H, Maruyama H*, Itoh K, Kido K, Saruta T// l Keio Univ, Sch Med, Dept Internal Med, 35 Shinanomachi, Shin- juku ku, Tokyo 160, Japan DIABm RES CLIN PRACT 1992,16 (3) 229 Arachidonic acid metabolites and alpha2- adrenoceptor-mediated glucagon secretion in rats.

Wolf JE, Massof SE, Peters SPII Thomas Jef- ferson Univ, Dept Med, Philadelphia, Pa 19107, USA INFEC IMMUNITY 1992,60 (7) 2559 Alteractions in murine macrophage arachidonic acid metabolism following ingestion of nonviable Histoplasma capsulatum.

McBride RK, Stone KK, Marin MG// Univ Rochester, Med Ctr, Sch Med & Dent, Dept Med, Pulm & Crit Care Unit, Box 692,601 Elmwood Ave, Rochester, NY 14642, USA AMER J PHYSIOL 1992,262 (6) Ptl, L694

Arachidonic acid increases choline@ secretory responsiveness of ferret tracheal glands.

Manso G, Baker AJ, Taylor IK, Fuller RW* // *Royal Postgrad Med Sch, Dept Clin Phar- macol, Ducane Rd, London W12 ONN, Eng- land EUR RESP J 1992,5 (6) 712 In vivo and in vitro effects of glucocorticoste- raids on arachidonic acid metabolism and monocyte function in nonasthmatic humans.

Lin LL, Lin AY, Knopf JU/ Genet Inst, 87 Cambridge Pk Dr, Cambridge, Ma 02140, USA PROC NAT ACAD SC1 USA 1992,89 (13) 6147 cytosolic phospholipase-A2 is coupled to hor- monally regulated release of arachidonic acid.

Rioux FM, Innis SM*// *Univ British Colum- bia, Res Ctr, Dept Paediat, 179-950 W 28th Ave, Vancouver, BC, Canada VSZ 4H4 AMER J CLIN NUTR 1992,56 (1) 106 Arachidonic acid concentrations in plasma and liver phospholipid and cholesterol esters of piglets raised on formulas with different linoleic and linolenic acid contents.

Towle CA, Weissbach L, Treadwell BV// Massachusetts Gen Hosp, Orthopaed Res Labs, Fruit St, Boston, Ma 02114, USA BIOCHIM BIOPHYS ACTA 1992,1131 (2) 223 Alternatively spliced annexin-XI transcripts encode proteins that differ near the amino terminus.

Jones PG, Moore GJ, Waisman DM’N ‘Univ Calgary, Dept Med Biochem, Calgaly, Alberta, Canada T2N 4N1 J BIOL CHEM 1992,267 (20) 13993 A nonapeptide to the putative F-actin binding site of annexin- tetramer inhibits its calcium-dependent activation of actin filament binding.

Cambronero JC, Rivas FJ, Borrell J, Guam C’// *CSIC, Cajal Inst, Dept Psychobiol, Doc- tor Arce 37, E-28002 Madrid, Spain J NEUROIMMUNOL 1992,39 (l-2) 57 Role of arachidonic acid metabolism on corti- cotropin-releasing factor (CRF)-release induced by interleukin-1 from superfused rat hypothalami.

Elderfield AJ, Newcombe J, Bolton C*, Flower FJ// l Univ Bath, Sch Pharm & Phar- macol, Claverton Down, Bath BA2 7AY, England J NEUROIMMUNOL 1992,39 (l-2) 91 Lipocortin (annexins) 1, 2,4 and 5 are increased in the central nervous system in multiple sclerosis.

Patte C, Blanquet PR’// *Assoc Calude Ber- nard, Unite Rech Gerontol, INSERM, U118, CNRS, 29 rue Wilhem, F-75016 Paris, France CELL MOL BIOL 1992,38 (4) 429 Possible involvement of arachidonic acid metabolites in the synergistic action of endothelial mitogenesis by basic fibroblast growth factor and phorbol ester.

Laethem RM, Laethem CL, Ding XX, Koop DR*// *Oregon Hlth Sci Univ, Sch Med,

Dept Pharmacol, 3181 SW Sam Jackson Pk Rd, I.221, Portland, Or 97201, USA J PHARMACOL EXP THER 1992,262 (1) 433 P-450dependent arachidonic acid metabolism in rabbit olfactory microsomes.

Abelli L, Nappi F, Perretti F, Maggi CA, Manzini S, Giachetti A// Fat Sci, Univ Tus- cia, Via San Camillo de L.&s, Block D, I- 01100 Viterbo, Italy J AUTONOM PHARMA COL 1992,12 (4) 269 Microvascular leakage induced by substance P in rat urinary bladder: involvement of cyclooxygenase metabolitcs of arachidonic acid.

Bennett PR, Elder MG// Queen Charlottes Matem Hosp, Royal Postgrad Med Sch, Inst Obstet & Gynaccol, London W6 OXG, Eng- land AMER J OBSll?I- GYNECOL 1992,166 (5) 1541 The mechanisms of preterm labor - common genital tract pathogens do not metabolize arachidonic acid to prostaglandins or to other eicosanoids.

Shimada T, Somlyo AP*// *Univ Virginia, Sch Med, Dept Physiol, Charlottesville, Va 22908, USA J GEN PHYSIOL 1992,100 (1) 27 Modulation of voltagedependent Ca channel current by arachidonic acid and other long- chain fatty acids in rabbit intestinal smooth muscle.

Maugeri N, Evangelista V, Piccardoni P, Del- lelba G, Celardo A, Degaetano G, Cerletti C*// l Consonio Mario Negri Sud, Ist Ric Farmacol Mario Negri, I-66030 Santa Maria Imbar, Italy BLOOD 1992,80 (2) 447 Transcellular metabolism of arachidonic acid - increased platelet thromboxane generation in the presence of activated polymorphonuclear leukocytes.

5. PROSTAGLANDINS E AND F Krasnikova T, Minchuna V, Runikhin A, Arabidze G, Mazaev A/l Acad Med Sci

USSR, Cardiol Res Ctr, Inst E+l Cardiol, 3rd Cherepkomkaya St 15A, Moscow 121552, Russia AMER J HYPERTENS 1992,5 (6) P2, S, s140 Regulation of the lymphocyte adenylate cyclase system by prostaglandin-E2 infusions in resistant hypertensive subjects.

Aoki Y, Yanagisawa Y, Oguchi H, Yazaki K, Furuta S// Shinshu Univ, Sch Med, Dept In- ternal Med, 3-l-l Asahi, Matsumoto, Nagano 390, Japan DIABETES RES CLIN PRACT 1!992,16 (3) 233 Possible participation of a prostaglandin El analogue in the aggravation of diabetic ne- phropathy.

Wilms G, Peene P, Steen0 0, Baert Au/ Univ Hosp Katholieke Leuven, Dept Radiol, Hercst 49, B-3000 Louvain, Belgium UROL RADIOL 1992,14 (1) 59 Intracavemosal injection of prostaglandin-El as an alternative for papaverine in penile

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angiography.

Sahai A, Sandier RS, Xu GH, Shayman JA, Tanncn RIJ/ Univ So Calif, Los Angeles Cty Med Ctr, Sch Med, Dept Med, Rm 7900, 1200 N State St, Los Angeles, Ca 90033, USA AMER J PHYSIOL 1992,262 (6) Pt2, F950 Signal transduction events whereby PGF2alpha inhibits the ammoniagenic response to acute acidosis.

Tokuda H, Miwa M, Oiso Y, Koxawa O*// ‘Nagoya Univ, Sch Med, Dept Internal Med, Nag&$ Aichi.466, Japan - CELL SIGNAL 1992.4 (3) 261 Autoregulation of prosta‘gandin-E(2)-induced Ca2 + influx in osteoblast-like cells - inhibition by self-induced activation of protein kinase-C.

Schmidtler J, Rosenthal W, Offermanns S, Schusdxiarra V, Classen M, Schepp W//Tech Univ Munich, Dept Internal Med 2, W-8000 Munich 2, Germany CELL SIGNAL 1992,4 (3) 321 Pertussis toxin reverses prostaglandin-E(2)- and somatostatin-induced inhibition of rat pa- rietal cell H + -production.

Cohenluria R, Rimon G’// *Ben Gurion Univ Negev, Corob Res Ctr, Dept Physiol, POB 653, II-81405 Beer Sheva, Israel CELL SIGNAL 1992,4 (3) 331 ProstaglandinE(2) can bimodally inhibit and stimulate the epididymal adipocyte adenylyl cyclase activity.

Sahatori R, Guidon PT, Rapuano BE, Bock- man RS*// ‘Hasp Special Surg, 535 E 70th St, New York, NY 10021, USA ENDOCRINOLOGY 1992,131(l) 21 Prostaglandin-El inhibits collagenase gene expression in rabbit synoviocytes and human fibroblasts.

Meuleman EJH, Bemelmans BLH, Does- burg wH, Vanasten WNJC, Skotnicki SH, De- bruyne FMJ// Univ Hosp Nijmegen, Dept Urol, Nijmegen, Netherlands J UROL 1992,148 (1) 63 Penile pharmacological duplex ultrasono- graphy - a dose-effect study comparing papaverine, papaverine phentolamine and prostaglandin-El.

Ito S, Sugama K, Inagaki N, Fukui H, Giles H. Wada H. Havaishi O// Osaka Biosci Inst. Dept Cell Biol, 6-24 Furuedai, Suita 565, Japan GLIA 1992,6 (1) 67 Type-1 and type-2 astrocytes are distinct tar- gets for prostaglandins D2, E2, and F2alpha.

Onoe H, Watanabe Y*, Ono K, Koyama Y, Hayaishi O// *Osaka Biosci Inst, Dept Neuro- sci, 6-2-4 Furuedai, Suita, Osaka 565, Japan J NEUROSCI 1992,12 (7) 2715 PmstaglandinE(2) exerts an awakening effect in the posterior hypothalamus at a site distinct from that mediating its febrile action in the anterior hypothalamus.

Perusquia M, Kubligarfias C// Inst Mexican0 Seguro Social, Unidad Invest Biomed, Apar- tado Postal 70492, CD Univ, Mexico City 04511, Mexico PROSTAGLANDINS 1992,43 (5) 445 External calcium dependence of the uterine contraction induced by prostaglandin-E-2 and pmstaglandinF2alpha and its antagonism with natural progestins.

Miyauchi M, Ijuhin N, Nikai H, Takata T, Ito H, Ogawn I// Hiroshima Univ, Sch Dent, Dept Oral Pathol, Hiroshima 730, Japan J PERIODONTOL 1992,63 (5) 405 Effect of exogenously applied prostaglandin- E2 on alveolar bone loss- histomeric analysis.

Dempster JA, Kellett GL*// ‘Univ York, Dept Biol, York YOl SDD, N Yorkshire, England J PHYSIOL-LONDON 1992.453 IJULl449 A submucosal mechanism of action’ for Pros- taglandinE2 on hexose absorption and metabolism in mouse intestine.

Tsukada K, Katoh H, Iga Y, Tomiyama T, Okamura N, SugimotoF, Ohtani T, Iiai T, Sakasuchi T. Yoshida K et al// Niieata Univ. Sch Med, Dept Surg, Niigata 951, Sapan GASTROENTEROL JPN 1992,27 (3) 341 Prostaglandin El enhances hepatic portal venous flow by dilating the portal vascular bed in 70percent hepatectomized dog.

Nishiyama K, Katori M, Ueno A, Ohno T, Saigenji K// Kitasato Univ, Sch Med, Dept Ph&t&ol, Sagamihara, Kanagawa 228, Japan DIGEST DIS SC1 1992.37 (7) 1002 Suppression of myoelectricai activity of gastric smooth muscle by endogenous gastric prostaglandin-E2.

Yoshimura K, Kraus ER, Shimakura S, Schei- man JM, Boland CR*// *Vet Adm Med Ctr, Dent Internal Med. 2215 Fuller Rd. Ann Arbor, Mi 48105, USA DIGEST DIS SC1 1992,37 (7) 1045 Role of prostaglandin-E2 in cholinergic-mediated glycoprotein synthesis in canine antrum.

6. PROSTACYCLIN Barnard JW, Ward RA, Taylor AE// Univ So Alabama, Coil Med, Dept Physiol, MSB 3924, Mobile, Al 36688, USA J APPL PHYSIOL 1992,72 (6) 2469 Evaluation of prostaglandinF2alpha and prostacyclin interactions in the isolated perfused rat lung.

Itoh H, Koyata H, Takahara T, Watanabe A, Hiraga.K*// l Toyama Med & Pharmaceut Univ. Sch Med. Deut B&hem, Sueitani, Toyama 93001,‘Ja~n - BIOCHEM BIOPHYS RES COMMUN 1992, 185 (3) 981 Prostacyclin administration suppresses the increase in hepatic levels of COLlA(1) and glyceraldehyde-3-phosphate dehydrogenase messenger RNAs in the rat treated with carbon tetrachloride.

7. THROMBOXANES Hood JS, Nossaman BD, Ibrahim IN, McMa- hon TJ, Babycos CR, Kadowitx PJ’N ‘Tu- lane Univ, Dept Pharmacol, 1430 Tulane Ave, New Orleans, La 70112, USA J APPL PHYSIOL 1992,72 (6) 2305 Daltroban blocks thromboxane responses in the pulmonary vascular bed of the cat.

LotvaIl J, Elwood W, Tokuyama K, Sakamo- to T, Barnes PJ, Chung KF// Gothenburg Univ. Sahlgrens Hasp, Dept Pharmacol, Div Clin Pha&acol, S-4i345 dothenburg, Sweden J APPL PHYSIOL 1992.72 (6) 2415 A thromboxane mimetic; U&619, produces plasma exudation in airways of the guinea pig.

Mene P, Taranta A, Pugliese F, Cinotti GA, Dagostino A// Policlin Umberto 1, Med Clin 2A, Cattedra Nefrol, Viale Policlin, 1-00161

Rome, Italy J LAB CLIN MED 1992,120 (1) 48 Thromboxane-A2 regulates protein synthesis of cultured human mesangial cells.

Stier CT, Wong PYK, Itskovitr HD// New York Med Coil, Dept Pharmacol, Valhalla, NY 10595, USA PROSTAGLANDINS 1992,43 (6) 533 Enhanced thromboxane formation by blood but not whole platelets from spontaneously hypertensive rats.

Okwu AK, Ullian ME, Halushka PV’// l Med Univ S Carolina, Dept Cell 8r Molec Pharmacol, Div Clin Pharmacol, 171 Ashley Ave, Charleston, SC 29425, USA J PHARMACOL EXP THER 1992.262 11’)

Homologous desensitization of human platelet thromboxane A2/prostaglandin H-2 receptors.

Miki I, Ishii N/ Kyowa Hakko Kogyo Co Ltd, Pharmaceut Res Labs, Sunyo, Shizuoka 411, Japan THROMB HAEMOST 1992,67 (5) 582 Characterization of thtomboxane-A2/prosta- glandinH2 receptors in porcine coronary artery - the inhibitoty effect of a novel diben- zoxepin derivative.

Jones GL, Lane C, Obyrne PM// McMaster Univ, Dept Med, Asthma Res Gtp, Hamil- ton, Ontario, Canada L8S 4L8 J PHYSIOL-LONDON 1992,453 (JUL) 59 Effect of an inhaled thromboxane mimetic (U46619) on in vivo pulmonary resistance and airway hyperresponsiveness in dogs.

Deboer A, Kroon JM, Kroon C, Vanvliet A, Schoemaker HC, Breimer D, Donoghue S, Cohen AFN Univ Utrecht, Fat Pharm, Dept Pharmacotherpay, POB 80082,3508 TB Utrecht, Netherlands THROMB HAEMOST 1992,68 (1) 24 Pronounced effects of the combination of a new thromboxane antagonist (GR32191) and heparin on bleeding time in man.

Bui KC, Martin G, Kammerman LA, Ham- merman C, Hill V, Short BL’// ‘Childrens Hosp, Natl Med Ctr, Div Neonatol, 111 Mi- chigan Ave NW, Washington, DC 20010, USA J THORAC CARDIOVASC SURG 1992, 104 (I) 124 Plasma thromboxane and pulmonary artery pressure in neonates treated with extracor- poreal membrane oxygenation.

8. LEUKOTRIENES Yakovlev VA, Udaltaov BB, Chumak GE, Karlov VA, Krasnokutskaya GN, Boll SV, Kurganova TA// SM Kirov Mil Med Acad, Chair Cardiol, St Petersburg, Russia TERAPEVT ARKH 1992,64 (3) 22 Metabolism of eicosanoids, glucocorticoids and cyclic nucleotides in young men with acute pneumonia (Russian)

Pilipchuk VN// AA Bogomolets Med Inst, Chair Hosp Therapy 3, Kiev, Ukraine VRACH DEL0 1992 (4) 37 Participation of the system of eicosanoids in formation of bronchial obstruction in chronic bronchitis (Russian)

Sawazaki S, Nakamura N, Hamazaki T’, Yamazaki K, Urakaze M, Yano S// l Toyama Med & Pharmaceut Univ, Dept Internal

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Med 1,263O Sugitani, Sugitani, Toyama 93001, Japan AMER J PHYSIOL 1992,262 (6) Pt2, H1711 Intravenous infusion of triekxxapentaenoyl- glycerol and LTB4 and LTBS production by leukqes of rabbits.

Smith CM, Hawksworth RI, Thien FCK, Christie PE, Lee TH’// *Guys Hasp, Dept Allergy 8c Allied Resp Disorders, 4th Floor, Hunts House, London SE1 9RT, England EUR RESP J 1992,5 (6) 693 Urinary leukotrieneE4 in bronchial asthma.

Sirtori CR, Gatti E, Tremoli E, Galli C, Gian- franceschi G, Franceschini G, Colli S, Mader- na P, Marangoni F, Perego P et al// Univ Milan, Ctr E Grossi Paoletti, Inst Pharmacol sci, Via Balzaretti 9,1-20133 Milan, Italy AMER J CLIN NUTR 1992,56 (1) 113 Olive oil, corn oil, and n-3 fatty acids differ- ently affect lipids, lipoproteins, platelets, and superoxide formation in type-11 hypercholes- terolemia.

Surette ME, Whelan J, Broughton KS, Kin- sella JE// CHU Lava], Unite Rech lnflammat Immunol & Rhumatol, 2705 Laurie& Quebec City, Quebec, Canada GlV 4G2 BIOCHIM BIOPHYS ACTA 1992,1126 (2) 199 Evidence for mechanisms of the hypotriglyce- ridemic effect of n-3 polyunsatured fatty acids.

Anderson GJ, Vanwinkle S, Connor WE// Oregon Hlth Sci Univ, Dept Med, Clin Nutr & Lipid Metab Sect, Portland, Or 97201, USA BIOCHIM BIOPHYS AC-IA 1992,1126 (2) 237 Reversibility of the effects of dietary fish oil on the fatty acid composition of the brain and retina of growing chicks.

Tsujii E, Tsurumi Y, Miyata S, Fujie K, Ka- wakami A, Okamoto M, Okuhara M/1 Fujisa- wa Pharmaceut Co Ltd, Exploratoty Res Labs, S-2-3 Tokodai, Tsukuba, Ibaraki 30026, Japan J ANI-IBIOT 1992,45 (5) 698 WFl1605, an antagonist of leukotrieneB4 produced by a fungus .l. Producing strain, fermentation, isolation and biological activity.

Shigematsu N, Tsujii E, Kayakiri N, Takase S, Tanaka H, Tada T// Fujisawa Pharmaceut Co Ltd, Exploratory Res Labs, S-2-3 Toko- dai, Tsukuba, Ibaraki 30026, Japan J ANIIBIOT 1992.45 (5‘1704 WF11605, an antagonist of leukotrieneB4 produced by a fungus .2. Structure determina- tion.

Brown FJ, Cronk LA, Aharony D, Snyder DW // ICI Pharmaceut Grp, Dept Med Chem, Wilmington, De 19897, USA J MED CHEM 1992,35 (13) 2419 1,3,6_trisubstituted indoles as peptidoleuko- triene antagonists - Benefits of a 2nd, polar, pyrrole substituent.

Goto S, Guo ZG, Futatsuishi Y, Hori H, Taira Z, Terada H*// l Univ Tokushima, Fat Pharmaceut Sci, Shomachi-1, Tokushima 770, Japan J MED CHEM 1992,35 (13) 2440 Quantitative structure-activity relationships of benzamide derivatives for anti-leukotriene activities.

Fayard JM, Timouyasse L, Guesnet P, Du-

rand G, Pascal G, Laugier C// Inst Natl Sci Appl, Physiol Pharmacodynam Lab, IN- SERM. U352. F-6%21 Villeurbanne. France J NlJTR 1992,122 (7) 1529 ’ Dietary alpha-linolenic acid deficiency and early uterine development in female rats.

Pax J, Douglass L, Sampugna J’// l Univ Ma- ryland, Dept Chem & Biochem, College Pk, Md 20742, USA J NUTR BIOCHEM 1992,3 (7) 342 Effects of linolenic and trans fatty acids on neonatal survival of C57BU6 mice.

Fauler J, Neumann C, Tsikas D, Frolich J I/ Hanover Med Sch, Dept Clin Pharmacol, POB 610180, W-3000 Hannover 61, FRG J INVEST DERMATOL 1992,99 (1) 8 Enhanced synthesis of cysteinyl leukotrienes in psoriasis.

Kohan DE// Dept Vet Affairs, Dept Ne- phrol, Salt LakeCity, Ut 84132, USA J LAB CLIN MED 1992. 120 fl) 4 Eicasanoids - Potential regulators of extracel- lular matrix formation in the kidney (Editor- ial)

Yamada N, Kadowaki S, Umezu K// Mitsubi- shi Kasei Carp, Res Ctr, Pharmaceut Lab, 1000 Kamoshida Cho, Midori ku, Yokohama 227, Japan PROSTAGLANDINS 1992,43 (6) 507 Development of an animal model of late asthmatic response in guinea pigs and effects of anti-asthmatic drugs.

Radeau T, Godard P, Chavis C, Depaulet AC, Damon M// INSERM, US860 Rue Na- vacelles, F-34090 Montpellier, France PROSI-AGLANDINS 1992,43 (6) 583 Enahnced esterification process of 5-hydroxyeicosatetraenoic acid (S-HEIE) in PMN from asthmatic patients.

Kumlin M, Dahlen B, Bjorck T, Zetterstrom 0, Granstrom E, Dahlen SE// Karolinska Inst, Dept Physiol Chem, POB 68400, S- 10401 Stockholm 60, Sweden AMER REV RESP DIS 1992,146 (1) 96 Urinary excretion of leukotriene-Et and ll- dehydro-thromboxane-B2 in response to bronchial provocations with allergen, aspirin, leukotriene-D4, and histamine in asthmatics.

Drazen JM, Obrien J, Sparmw D, Weiss ST, Martins MA, Israel E, Fanta CH// Brigham & Womens Hosp, Dept Med, Program Off, Combined Program Pulm Crit Care Med, 75 Francis St, Boston, Ma 02115, USA AMER REV RESP DlS 1992,146 (1) 104 Recovety of leukotrieneE4 from the urine of patients with airway obstruction.

Magaro M, Zoli A, Altomonte L, Mirone L, Desole P, Dimario G, Deleo E// Catholic Univ Sacred Heart, Div Rheumatol, 1st Clin Med, Iargo A Gemelli 8, I-00168 Rome, Italy ANN RHEUM DIS 1992,51(7) 877 Effect of fish oil on neutrophil chemilumines- cence induced by different stimuli in patients with rheumatoid arthritis.

Black HS, Thomby JI, Gerguis J, Lenger W// Vet Affairs Med Ctr, Houston, TX 77030, USA PHOTOCHEM PHOTOBIOL 1992,56 (2) 195 Influence of dietaty omega-6, omega-3 fatty acid sources on the initiation and promotion stages of photocarcinogenesis.

Jackson RI-I, Morrissey MM, Sills MA, Jarvis MF*// l Rhone Poulenc Rorer, Cent Res, 500 &cola Rd, POB 1200, Collegeville, Pa 19426, USA J PHARMACOL EXP THER 1992,262 (1) 80 Comparison of antagonist and agonist binding to the leukotrieneB4 receptor on intact human polymorphonuclear neutrophils (PMN)

Hamazaki T// Toyama Med & Pharmaceut Univ, Dept Internal Med 1, 2638 Sugitani, Tovama 93001, Japan PIiOC SOC EXP-BIOL MED 1992,200 (2) 171 Intravenous infusion of n-3 polyunsaturated fatty acids.

Okuyama H// Nagoya City Univ, Fat Pharma- ceut Sci 3-1 Tanabedori, Mizuho ku, Nagoya, Aichi 467, Japan ;‘OC SOC EXP BIOL MED 1992,200 (2)

Minimum requirements of n-3 and n-6 essential fatty acids for the function of the central nervous vtem and for the prevention of chronic disease.

Dolecek TA!/ Mrfit Coordinating Ctr, Suite 200,222l Univ Ave SE, Minneapolis, Mn 55414, USA PROC SOC EXP BlOL MED 1992,200 (2) 177 Epidemiological evidence of relationships between dietary polyunsaturated fatty acids and mortality in the multiple risk factor intetven- tion trial.

Blackbum GU/ Harvard Univ, New England Deaconess Hasp, Sch Med, Dept Surg, Bos- ton, Ma 02215, USA PROC SOC EXP BIOL MED 1992, u)o (2) 183 Nutrition and inflammatory events - highly unsaturated fatty acids (omega-3 vs omega-6) in surgical injury.

Meydani SN// Tufts Univ, Nutr Immunol Lab, USDA, Human Nutr Res Ctr Aging, 711 Washington St, Boston, Ma 02111, USA PROC SOC EXP BIOL MED 1992,200 (2) 189 Modulation of cytokine production by dietary polyunsaturated fatty acids.

Heidvall K, Radestad A, Christensen NJ, Lindgren JA// Karolinska Inst, Dept Physiol Chem, S-18401 Stockholm 60, Sweden PROSTAGLANDINS 1992,43 (5) 473 Production of 12-hydroxyeicosatetraenoic acid in early pregnant uterine cetvix-lack of correlation to mifepristone-induced cervical ripening - a double-blind randomized bioch- mechanical and biochemical study.

Pasetto N, Zicari A, Piccione E, Lenti L, Pontieri G, Ticconi C// Univ Rome, Policlin Nuovo S Eugenio, Ostetr & Ginecol Clin, P Umanesimo, I-00144 Rome, Italy AMER J OBSTEI GYNECOL 1992,166 (5) lSo0 Influence of labor and oxytocin on in vitro leukotriene release by human fetal membranes and uterine decidua at term gestation.

Bjorck T, Gustafsson LE, Dahlen SE// Karo- linska Inst, Dept Physiol 1, S-10401 Stock- holm 60, Sweden AMER REV RESP DIS 1992,145 (5) 1087 Isolated bronchi from asthmatics are hyperre- sponsive to adenosine, which apparently acts

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indirectly by liberation of leukotrienes and histamine.

Gray PR Derksen FJ’, Broadstone RV, Ro- binson NE, Johnson HG, Olson NU/ l Michi- can State Univ. Coil Vet Med. Pulm Lab. E Lnsing, Mi 48824, USA AMER REV RESP DIS 1992,145 (5) 1092 Increased pulmonary production of immu- noreactive 15hydroxyeicosatetraenoic acid in an animal model of asthma.

Dias VC, Wallace JL, Parsons HG*// ‘Univ Calgaty, Fat Med, Dept Pediat, 3330 Hosp Dr, Calgary, Alberta, Canada T2N lN4 GUT 1992,33 (5) 622 Modulation of cellular phospholipid fatty acids and leukotrieneB4 synthesis in the human intestinal cell (C&o-2)

Findlay SR, Barden JM, Easley CB, Glass MN Care of Psomas M J, ICI Americas Inc, Clin & Med Affairs, OW 2, Concord Pike & New Murphy Rd, Wilmington, De 19897, USA J ALLERG CLIN IMMUNOL 1992,89 (5) 1040 Effect of the oral leukotriene antagonist, ICI 204,219, on antigen-induced bronchoconstric- tion in subjects with asthma.

Textor SC, Wilson DJ, Lerman A, Romero JC, Burnett JC, Wiesner R, Dickson ER, Krom RAF// Mayo Clin & Mayo Fdn, Div Hypertens, Desk E16A, Rochester, Mn 55905, USA TRANSPLANTATION 1992,514 (1) 74 Renal hemodynamics, urinary eicosanoids, and endothelin after liver transplantation.

Navarro MD, Hortelano P’, Periago JL, Pita MU/ ‘Univ Granada, Fat Pharm, Dept Biochem & Molec Biol, E-18071 Granada, Spain ARTERIOSCLER THROMB 1992,12 (7) 830 Effect of dietary olive and sunflower oils on the lipid composition of the aorta and platelets and on blood eicosanoids in rats.

Suda N, Morita I, Kuroda T, Murota SI// Tokyo Med & Dent Univ, Grad Sch, Physiol Chem Sect, Yushima, Bunkyo ku, Tokyo 113, Japan INFLAMMATION 1992,16 (4) 307 Priming effects of leukotrieneB4 on endotheliai cell injury induced by TPA-activated leukocytes.

Smith JM, Paulson DJ, Labak S// Chicago Coil Osteopath Med, Dept Physiol, 555 31st St, Downers Grove, II 60515, USA AMER J HYPERTENS 1992,5 (7) 473 Effects of dietary fish oil on Rb + efflux from aorta of stroke prone spontaneously hypertensive rats.

Lanzajacoby S, Smythe C, Phetteplace H, Ta- bares A// Thomas Jefferson Univ, Jefferson Med Coil, Dept Surg, Philadelphia, Pa 19107, USA J PARENT ENTER NUTR 1992,16 (4) 353 Adaptation to a fish oil diet before inducing sepsis in rats prevents fatty infiltration of the liver.

Brezinski DA, Nesto RW, Serhan CN*// *Brieham & Womens Hosp. Dept Med, Div Hematol, LMRC 6,221 Ldngwood Ave, Bos- ton, Ma 02115, USA CIRCULATION 1992,86 (1) 56 Angioplasty triggers intracoronary leuko-

trienes and lipoxin-A4 - impact of aspirin therapy.

Hawthorne AB, Daneshmend TK, Hawkey CJ*, Belluzzi A, Everitt SJ, Holmes GKT, Malkinson C, Shaheen MZ, Wiilars JE// ‘Univ Nottingham Hosp, Dept Therapeut, Nottingham NG7 2UH, England GUT 1992,33 (7) 922 Treatment of ulcerative colitis with fish oil supplementation - a prospective 12 month randomised controlled trial.

9. PLATELET-ACTIVATING FACTOR Kuznetsova TI, Kulikov VI// Minist Hith Rus- sian Federat, Sci Ind Ctr Med Biotechnol, Moscow, Russia BIOCHEMISTRY-ENGL TR 1992,57 (1) Pt 1,lO Effects of plasmalogen and acyl structural analogs of platelet-activating factor on superoxide radical production by human leukocytes

Chepenik KP, Wykle Ru/ Thomas Jefferson Univ, Jefferson Med Coil, Dept Anat, 1020 Locust St, Philadelphia, Pa 19107, USA BIOCHIM BIOPHYS ACI-A 1992,1126 (2) 192 Synthesis of platelet activating factor and metabolism of related lipids in embryonic cells.

Kojima S, Nara K, Inada Y, Hirose S, Saito Y*// l Tohyo Inst Technol, Dept Biol Sci, Me- guro ku, Tokyo 152, Japan BIOSCI REP 1992, 12 (1) 15 Existence of lipid vesicles containing platelet- activating factor in endothelial cell &sate.

Matsumoto K, Taki F, Kondoh Y, Taniguchi H, Takagi K// Shiga Univ Med Sci, Dept Or- thopaed Surg, Otsu, Shiga 52021, Japan CLIN EXP PHARMACOL PHYSiOL 1992, 19 (7) 509 Platelet-activating factor in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome.

Pretolani M, Lefort J, Venco C, Perrisoud D, Vargaftig BB// Inst Pasteur, Unite Pharma- col Cellulaire, INSERM, U285,25 rue Dr Roux, F-75724 Paris 15, France EUR J PHARMACOL 1992,216 (2) 141 Inhibition by azelastine of the effects of platelet-activating factor in lungs from actively sensitised guinea-pigs.

Herbert JM, Laplace MC, Bemat A, Salei V, Maffrand JP// Sanofi Rech, Hemobiol Res Dept, 195 Route Espagne, F-31036 Toulouse, France EUR J PHARMACOL 1992,216 (2) 175 Effect of SR-27417 on oedema formation induced in rabbit skin by platelet-activating factor or antigen.

Hogaboam CM, Donigigale D, Shoupe TS, Wallace JL’// ‘Univ Calgary, Dept Med Physiol, 3330 Hosp Dr NW, Calgary, Alberta, Canada T2N 4Nl EUR J PHARMACOL 1992,216 (2) 315 PF-5901 inhibits gastrointestinal platelet-activating factor synthesis in vivo.

Dimaria GU, Bellofiore S, Ciancio N, Ruggie- ri F. Mistretta A// Univ Catania, 1st Malattie Resp, Via Passo Gravina 187, I-95125 Cata- nia, Italy CHEST 1992,102 (1) 123 Nedocromil sodium inhibits the increase in

airway reactivity induced by platelet activating factor in humans.

Ahmed A, Smith SK// Univ Cambridge, Rosie Matem Hosp, Dept Obstet & Gy- naecol, Cambridge CB2 2SW, England J CELL PHYSIOL 1992,152 (1) 207 Platelet-activating factor stimulates phospholipase-C activity in human endometrium.

Sun DX, Rui YC, Zeng GQ, Zhu J, Shen YA // Mil Med Coli 2. Sch Pharm. Dent Pharmacol, Shanghai 200433, PeoPles k China ACTA PHARMACOL SIN 1992,13 (4) 326 Specific binding sites of platelet activating factor on the intact bovine cerebral microvascular endotheliai cells and antagonism of drugs.

Appleyard CB, Hillier K’// l Univ Southamp ton, Fat Med, Clin Pharmacol Grp, Biomed Sci Bldg, Bassett Crescent E, Southampton SO9 3TU, Hams, England BIOCHEM PHARMACOL 1992,43 (12) 2503 Catabolism of platelet-activating factor by human colonic mucosa - Calcium dependence of the catabolizing enzymes.

Yue TL, Gu JL, Feuerstein G/I Smithkiine Beecham Pharmaceut, Dept Pharmacol, POB 1539, UW-2510, King of Prussia, Pa 19406, USA NEUROCHEM RES 1992,17 (10) 997 Protein kinase-C activator phorbol-12,13- dibutyrate inhibits platelet activating factor- stimulated Ca2 + mobilization and phosphoi- nositide turnover in neurohybrid NGlOLt-15 cells.

Orevi M, Rigbi M, Hyam E, Matzner Y, Eldor A// Hebrew Univ Jerusalem, Inst Life Sci, Dept Biol Chem, IL-91904 Jerusalem, Is- rael PROSTAGLANDINS 1992,43 (5) 483 A potent inhibitor of platelet activating factor from the saliva of the leech Hirudo medicinal&

Jamaluddin M, Thomas A// Sree Chitra Tiru- nal Inst Med Sci & Technol, Thrombosis Res Unit, Thiruvananthapuram 695012, India J BIOSCIENCES 1992,17 (2) 141 Platelet activating factor-induced aggregation of calf platelets - apparant positive coopera- tivity in the kinetics and non competitive inhibition by diltiazem.

Nathan N, Aissa J, Benveniste J, Amoux B// CHU Dupuytren, Dept Anaesthesiol, 2 Ave Alexis Carrel, F-87042 Limoges, France EUR J ANAESTH 1992,9 (4) 347 Role of paf-acether in protamine-induced thrombocytopenia in rabbits.

Kurose 1, Miura S, Fukumura D, Tashiro H, Imaeda H, Shiozaki H, Suematsu M, Nagata H, Sekizuka E, Tsuchiya M*// l Keio Univ, Sch Med, Dept Internal Med, Shinanomachi 35. Shiniuku ku. ToLvo 160. Jaoan Girr1!%2,33(7)&3 - Role of platelet activating factor on the fibri- nolytic activation in the pathogen&s of gastric mucosal damage induced by endothelin-1.

Corcoran PC, McKnealIy MF, Haverich A, Kennedy JH, Wang YN, Katz NM, Rajan SS, Analouei AR, Foegh ML, Wallace RBl/ Georgetown Univ, Med Ctr, Dept Surg, Div Cardiothorac Surg, 4th Floor, PHC Bldg, 3fIOO Reservoir Rd NW, Washington, DC

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20007, USA J THORAC CARDIOVASC SURG 1992, 104 (1) 66 Platelet activating factor antagonist enhances lung preservation in a canine model of single lung allotransplantation.

10. METABOLITES Christman BW, Mcpherson CD, Newman JH, Kina GA, Bernard GR, Groves BM, Lqd Jg// Vanderbilt Univ, Med Ctr, Sch Med. Ctr Lune Res. Div Pulm & Crit Care Med; Nashvin;, Tn j7232, USA N ENGL J MED 1992,327 (2) 70 An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension.

11. RELATED ENZYMES Zabolotsky DA, Ludwig P, Kuhn H, Schewe T. Mvaekova GI// MV Lomonosov Fine Cheh fechnol Inst, Moscow, Russia BIOCHEMISTRY-ENGL TR 1992,.57 (1) Pt 1,32 Inhibition of soybean lipoxygenase by a fu- ranoic fatty acid.

Rogers 3, Yu BZ, Jain MK*// ‘Univ Dela- ware, Dept Chem & Biochem, Newark, De 19716, USA BIOCHEMISTRY-USA 1992.31 (2616056 Basis for the anomalous effeci of con&titive inhibitors on the kinetics of hydrolysis of short-chain phosphatidylcholines by phospholipase-A2.

Raghupathi R, Franson RC*// *Virginia Commonwealth Univ, Dept Biochem & Molec Biophp Box 614, MCV !?IN, Rich- mond, Va 23298, USA BIOCHIM BIOPHYS ACTA 1992,1126 (2) 206 Inhibition of phospholipase+Q by cis-unsaturated fatty acids - evidence for the binding of fatty acid to enzyme.

Konrad RI, Jolly YC, Major C, Wolf BA’// l Univ Penn, Sch Med, Dept Pathol & Lab Med, 217 John Morgan, Philadelphia, Pa 19104, USA BIOCHIM BIOPHYS ACI-A 1992,113s (2) 21s Inhibition of phospholipaseA2 and insulin secretion in pancreatic islets.

Knust B, Vonwettstein D// Carlsberg Lab, Dept Physiol, Gamle Carlsberg Vej 10, DK- 2500 Copenhagen, Denmark APPL MICROBIOL BIOTECHNOL 1992, 37 (3) 342 Expression and secretion of pea-seed lipoxygenase isoenzymes in Saccharomyces cerevi- siae.

Ferrer X, Moreno JJ// Univ Barcelona, Fat Farm, Dept Ciencias Fiiiol Humanas & Nutr, Fisiol Lab, Av Joan XXIII S-N, E- 08028 Barcelona, Spain COMP BIOCHEM PHYSIOL PT C 1992, 102 (2) 325 Effects of copper, iron and zinc on oedema formation induced by phospholipaseA2.

Sakamoto K, Arakawa H, Yamashita SI, Mizuta H, Takaki K, Ogawa M*// l Kumamo- to Univ, Sch Med, Dept Surg 2, Kumamoto 860, Japan RES COMMUN CHEM PATHOL PHARM 1992,76 (3) 279 Membrane-associated phospholipaseA2 de- tected by a radioimmunoassay is a sensitive

marker of inflammation in rheumatoid arthritis.

Odenwaller R, Maddipati KR, Mamett LJ// Vanderbilt Univ, Med Ctr, Sch Med, Dept B&hem, AB Hancock Jr Mem Lab Cant Res, Ctr Molec Toxicol, Nashville, Tn 37232, USA J BIOL CHEM 1992,267 (20) 13863 Detection of a higher oxidation state of manganese-prostaglandin endoperoxide synthase.

Strieder S, Scherer I-IJ, Schaible K, Dietz R, Ruf HH*// ‘Univ Saarland, Fmunhoffer Inst Biomed Tech, FHG IBMT, Ensheimerstr 48, W-6670 St Ingbert, FRG J BIOL CHEM 1992,267 (20) 13870 Prostaglandin endoperoxide synthase sub- stituted with manganese protoporphyin-IX - formation of a higher oxidation state and its relation to cyclooxygenase reaction.

Carey PD, Jenkins JK, Byrne K, Walsh CJ, Fowler AA, Sugerman HJ*// *Virginia Corn- monwealth Univ, Med Co11 Virginia, Dept Surg, Box 519, MCV Stn, Richmond, Va 23229, USA SURGERY 1992,112 (1) 45 The neutrophil respiratory burst and tissue injury in septic acute lung injury - the effect of cyclooxygenase inhibition in swine.

Paul JA, Gregson NA// United Med Kc Dent Sch Guys & St Thomas Hosp, Div Anat & Cell Biol, Guys Campus, London SE1 9RT, England .I NEUROIMMUNOL 1992,39 (l-2) 31 An immunohistochemical study of phospholipase-A2 in peripheral nerve during Wallerian degeneration.

Tocco G, Massicotte G, Standley S, Thom- pson RF, Baudry M*// l Univ So California, Promam Neurosci, Hedco Neurosci Bldg, Los-Angeles, Ca 9&89, USA NEUROREPORT 1992.3 f61SlS Phospholipase A2-induced ‘changes in AMPA receptor - an autoradiographic study.

Schorer AE, Duane PG, Woods VL, Nie- woehner DE’/ Univ Minnesota, Minneapolis Vet Affairs Med Ctr, Dept Med, Div Hima- tol. Minneaoolis. Mn 55417. USA J i.AB CL& MED 1992, li0 (1) 67 Some antiphospholipid antibodies inhibit phospholipase-A2 activity.

Eling TE, Curtis JF// NIEHS, Molec Biophys Lab, Eicosanoid Biochem Sect, POB 12233, Res Triangle Pk, NC 27709, USA PHARMACOL THER 1992,53 (2) 261 Xenobiotic metabolism by prostaglandin-H synthase.

Sakuma S, Fujimoto Y, Nishida H, Sumiya T, Yamamoto I, Fujita T// Osaka Univ Pharma- ceut Sci, Dept Hyg Chem, 2-10-6.5 Kawai, Matsubara, Osaka 580, Japan PROflAGLANDINS 1992,43 (5) 435 Inhibition of prostaglandindeltal3 reductase activity in rabbit kidney cortex by giutathione disulfide.

Sinzinger H/1 Wilhelm Auemvald Atheroscle- rosis Eees Grp ASF, Vienna, Austria AMER J HEMATOL 1992,40 (2) 1.57 12-lipoxygenase and vascular disease (Letter)

Choumet V, Faure G, Robbevincent A, Sa- liou B, Mazie JC, Bon C’// l lnst Pasteur, IN- SERM, U285, Unite Venins, 25 rue Dr Roux, F-75724 Paris 15, France

MOL IMMUNOL 1992,29 (78) 871 Immunochemical analysis of a snake venom phospholipasc42 neurotoxin, croti, with monoclonal antibodies.

Asaoka Y, Oka M, Yoshida & Sasaki Y, Ni-. shizuka Y// Kobe Univ. Biosienal Res Ctr. Kobe 657, Japan ” PROC

12. PRODUCTION AND RELEASE Takabatake T, Hara H, Ishida YI, Ohta H, Kobayashi KIN Kanazawa Univ, Sch Med, Dept Internal Med 1,13-l Takaramachi, Ka- nazawa, Ishikawa 920, Japan AMER J PHYSIOL 1992,262 (6) Pt2, MO47 Renal effects of endogenous prostaglandin synthesis promoter ONO-3122.

Navarra P, Pozzoli G, Brunetti L, Ralcazzoni E, Besser M, Grossman A// Hosp Raion & Cabal, Nephrol Serv. Carr Colmenar. Km 91&E&l34 Madhd, Spain NEUROENDOCRINOLOGY 1992,56 (1) 61 Interleukin-lbeta and interleukin-6 spccifi- tally increase the release of pmstaglandin- E(2) from rat hypothalamic explants in vitro.

Preclik G, Strange EF, Ditschuneit I-I// Univ Ulm, Dept Internal Med 2, Robert Koch Str

B26

8, W-7900 Ulm, FRG PROSTAGLANDINS 19!Z,43 (6) 545 PGEZ secretion from organ cultured gastric mufOSa - Correlation with cyclooxygenase activity and endogenous substrate release.

Ryseck RP, Raynoschek C, MacDonaldbravo H, Dorfman K, Mattci MG, Bravo R’// *Bristol Myers Squibb Pharmaceut Res Inst, Deot Molec Biol, POB 4000, Princeton, NJ 08543, USA CELL GROW DIFFER 1992.3 tn 443 Identification of an immediate early g&e, pghs-b, whose protein product has prostaglandin synthase/cyclooxygenase activity.

Stier <JT, Quilley CP, McGiff JU/ New York Med Cdl, Dept Pharmacol, Basic Sci Bldg, Valhalla, NY 10595, USA J PHARMACOL EXP THER 1992,262 (1) 252 Endothelind effects on renal function and prostanoid release in the rat isolated kidney.

Ninomiya H, Yu XY, Hasegawa S, Spann- hake EW*// *Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Environm Hfth Sci, 615 N Wolfe St, Baltimon, Md 21205, USA PROSTAGLANDINS 1992,43 (S) 401 Endothelin-1 induces stimulation of prostaglandin synthesis in cells obtained from canine airways by bronchoalveolar lavage.

Skinner SJM, Somervell CE, Olson DMN Univ Auckland, Sch Med, Dept Pediat, Auck- land, New Zealand PROSTAGLANDINS 1992,43 (5) 413 The effects of mechanical stretching on fetal rat lung cell prostacyclin production.

Hotter G, Rosellocatafau J, Closa D, Bulbe- na 0, Lnpezboado MA, Femandezcruz L, Gelpi E// CSIC, Ctr Invest & Desarrollo, Dept Neurochem, Eicosanoid Branch, Jordi Girona 18-26, E-08034 Barcelona, Spain PROSTAGLANDINS 1992,43 (5) 497 Pancreas pmstanoid production in &hernia and reperfusion.

Lokesh B, Licari J, Kinsella JE*// *Univ Calif Davis, till Agr & Environm Sci, Deans Off, 200 Mrak Hall, Davis, Ca 95616, USA J PARENT ENTER NUTR 1992,16 (4) 316 Effect of different dietary triglycerides on liver fatty acids and prostaglandin synthesis by mouse peritoneal cells.

13. EFFECTS Plass H, Roden M, Wiener H, Tumheim K// Univ Vienna, Inst Pharmakol, Wahringer Str 13A, A-1090 Vienna, Austria BIOCHIM BIOPHYS ACTA 1992,1107 (1) 139 Vanadium-induced Cl-- secretion in rabbit descending colon is mediated by prostaglandins.

Roscnblum WI, Nishimura H, Ellis EF, Nel- son GH// Virginia Commonwealth Univ, Med Coil Virginia, Dept Pathol Neuropa- thol, Box 17, MCV Stn, Richmond, Va 23298, USA J CEREBR BLOOD FLOW METABOL 1992,12 (4) 703 The endotheliumdependent effects of thim- erosal on mouse pial arterioles in v-iv0 - evidence for control of microvascular events by EDRF as well as prostaglandins.

Strong P, Coleman RA, Humphrey PPA// Glaxo Grp Res Ltd, Div Pharmacol, Ware

SG12 QDJ, Herts, England PROSTAGIANDINS 1992,43 (6) 559 Prostanoid-induced inhibition of lipolysis in rat isolated adipocytes - Probable involvement of EP3 receptors.

Hatmi M, Havet N, Vargaftig BB, Bachelet M/1 Inst Pasteur. INSERM. U28.5. Unite Ph&macol Cell;laire, 2.5 rue Dr Roux, F- 75724 Paris 15, France PROSI’AGLANDINS 1992,43 (5) 457 Azelastine potentiates the prostaglandin-induced increase of cyclic AMP content in human platelets and in guinea-pig alveolar macrophages.

Amici C, Sistonen L, Santoro MG, Morimo- to RI// Univ Rome Tor Vergata, Dept E!xptl Med & Biochem Sci, 1-001~ Rome, Italy PROC NAT ACAD SC1 USA 1992,89 (14) 6227 Antiproliferative prostaglandins activate heat shock transcription factor.

Kandasamy SB, Harris AH// Armed Forces Radiobiol Res Inst, Dept Behav Sci, Bethes- da, Md 20889, USA RADIAT RES 1992,131 (1) 43 Effect of prostaglandins, inositol 1,4,5-tris- phosphate, and phorbol esters on radiation- induced decreases in calcium influx in rat brain synaptosomes.

14. PROSTAGLANDINS IN MEDICINE Amatuni VG, Malayan KL, Zakharyan AK// Yerevan Med Inst, Chair Internal Med, Yere- van, Armenia TERAPEVT ARKH 1992,64 (3) 61 The impact of a single intake of nifedipine, intal, sodium thiosulfate and essentiale on the blood content of calcium, hydroperox- ides, thiol compounds and prostaglandins in bronchial asthma patients (Russian)

Armstrong DA// Cleveland Clin Fdn, Dept Vast Cell Biol & Atherosclerosis, 9500 Eu- clid Ave, Cleveland, Oh 44195, USA MED HYPOTHESES 1992,38 (3) 244 Oxidized LDL, ceroid, and prostaglandin metabolism in human atherosclerosis.

Hoogenberg K, Tupker RA, Vanessen LH, Smit AI, Kallenberg CGM// Univ Groningen Hosp, Dept Internal Med, POB 30001,9700 RB Groningen, Netherlands BRIT J DERMATOL 1992,127 (1) 64 Successful treatment of ulcerating livedo-re- ticularis with infusions of prostacyclin (Let- ter)

Hooper SB, Harding R Deayton J, Tbor- bum GD// Monash Univ, Dept Physiol, Clay- ton, Vie 3168, Australia AMER J OBSTET GYNECOL 1992,166 (5) 1568 Role of prostaglandins in the metabolic responses of the fetus to hypoxia.

Honigl W, Lang PFJ, Weiss PAM, Winter R // Graz Univ, Dept Obstet & Gynaecol, A- 8036 Graz, Ausria HUM REPROD 1992.7 (4) 573 Intrauterine pregnancy after treatment of tubal pregnancy with local and systemic prostaglandins in a patient with a single oviduct - case report.

Henriquezlaroche C, Rodrigueziturbe B, Parra G// Apartado Postal 1430, Maracaibo 4001-A, Zulia, Venezuela

CLIN SC1 1992,83 (1) 75 Increased urinary excretion of prostaglandin- E2 in patients with idiopathic hypercalciuria is a primary phenomenon.

Sorensen SS, Colov NP, Andreasson B, Bock JE, Berget A, Schmidt T// Aeblevangen 90, DK-2765 Smorum, Denmark ACI-A OBSTEI- GYNECOL SCAND 1992, 71 (3) 201 Induction of labor by vaginal prostaglandin- E2 a randomized study comparing pessaries with vaginal tablets.

15. PROSTAGLANDINS AS DRUGS Giedrojc J, Breddin HK// Univ Frankfurt, Ctr Internal Med, Dept Angiol, Theodor Stem Kai 7, W-6000 Frankfurt 1, FRG INT J MICROCIRC-CLIN EXP 1992,11(3) 277 Effects of combinations of a prostacyclin analogue (Cicaprost) with different anti- thrombotic agents in a rat microcirculatoIy thrombosis model.

Yasuda H, Sonobe M, Hisanaga T, Kawabata T, Maeda K, Kikkawa R, Shigeta Y// Shiga Univ Med Sci, Dept Med 3, Otsu, Shiga 52021, Japan METABOLISM 1992,41(7) 778 A combination of the aldose reductase inhibitor, statil, and the prostaglandin-El analogue, OP1206.alphaCD, completely improves sciatic motor nerve conduction velocity in streptozocin-induced chronically diabetic rats.

Adachi H, Irie T, Hirayama F, Uekama K’ // ‘Kumamoto Univ, Fat Pharmaceut Sci, 5-l Oe Honmachi, Kumamoto 862, Japan CHEM PHARM BULL TOKYO 1992,40 (6) 1586 Stabilization of prostaglandin El in fatty alcohol propylene glycol ointment by acidic cyclo- dextrin derivative, ortho-carboxymethyl- ortho-ethyl-beta-cy clodextrin.

Schimer M, Schneider MR.// *Schering Ag, Res Lab, Mullerstr 170.178, W-1000 Berlin 65, FRG J CANCER RES CLIN ONCOL 1992,118 0 497 The prostacyclin analogue cicaprust inhibits metastasis of tumours of R-3327~MAT-Lu prostate carcinoma and SMT-2A mammaty carcinoma.

Thong KJ, Baird DT// Univ Edinburgh, Ctr Reprod Biol, Dept Obstet & Gynaecol, 37 Chalmers St, Edinburgh EH3 9EW, Scotland ACI’A OBSIEI- GYNECOL SCAND 1992, 71 (3) 191 An open study comparing two regimens of gemeprost for the termination of pregnancy in the second trimester.

Larsen KR, Dajani EZ, Ives MM// Vet Adm Med Ctr, 151-H, SO0 Fothill Blvd, Salt Lake City, Ut 84148, USA DIGEST DIS SCI 1992,37 (7) 1029 Antiulcer drugs and gastric mucosal integrity - effects of misopmstol, 16,16dimethyl PGE2, and cimetidine on hemodynamics and metabolis rate in canine gastric mucosa.

16. INHIBITORS OF SYNTHESIS Khoo NKS, Chan FPH, Saarloos MN, Lala PK*// l Univ Western Ontario, Dept Anal, London, Ontario, Canada N6A SC1 CLIN EXP METASTASIS 1992,lO (4) 239 Immunotherapy of mammary adenocarcino-

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ma metastases in CXI/I-Ien mice with chronic administration of cyclo-oxygenase inhibitors alone or in combination with IL-2.

Cross DS, Platt JL, Juhn SK, Back FH, Adams GL*// l Univ Minnesota, Dept Otol- aryngoi, Harvard & E River Rd, UMHC Box 396, Minneapolis, Mn 55455, USA ARCH OTOLAR-HEAD NECK SURGERY 1992,118 (5) 526 Administration of a prostaglandin synthetase inhibitor associated with an increased immune cell infiltrate in squamous cell carcinoma of the head and neck.

17. Indomethacin Smelt AHM, Meindem AE, Hoekman K, Noort WA, Keime MJNC// Leiden Univ Hasp, Dept Gen Internal Med, Cl-R41, POB 9600,230O RC Leiden, Netherlands PROSTAGIANDINS 1992,43 (6) 567 Secretory diarrhea in vilous adenoma of rec- tum - Effect of treatment with somatostatin and indomethacin.

Vanloon FPL, Rabbani GH, Bukhave K, Raskmadsen J*// l Univ Copenhagen, Bispeb- jerg Hosp, Dept Med G, DK-2400 Copen- hagen, Denmark GUT 1992,33 (5) 643 Indomethacin decreases jejunal fluid secre-

tion in addition to luminal release of prostaglandin-E2 in patients with acute cholera.

18. CHEMICAL SYNTHESIS Narita S, Takahashi A, Sato H, Aoki T, Yamada S, Shibasaki Ml/ Toa Eiyo Ltd, Fu- kushima Res Labs, 1 Tanaka, Iizuka, Fukushi- ma 96002, Japan TETRAHEDRON LEIT 1992,33 (28) 4041 An improved method for the introduction of carbon-carbon triple bond at C-13 in PG synthesis.

19. TECHNIQUES Ekholm J, Tatsumi Y*, Nouchi T, Hanahan DJ// l UnivTexas, Hlth Sci Ctr, Dept Biochem, 7703 Floyd Curl Dr, San Antonio, TX 78284, USA ANAL BIOCHEM 1992,204 (1) 79 The human platelet as a reproducible and sensitive cell for the detection and assay of platelet-activating factor.

Lehmann WD, Stephan M, Futstenberger G// German Cant Res Ctr, Dept Cent Spect, Neuenheimer Feld 280, W-6900 Heidelberg 1, FRG ANAL BIOCHEM 1992,204 (1) 158 Profiling assay for lipoxygenase products of linoleic and arachidonic acid by gas chromato-

graphy-mass spectrometry.

Reynolds LI, Hughes LL, Dennis EA// Univ Calif San Diego, Dept Chem, La Jolla, Ca 92093, USA ANAL BIOCHEM 1992,204 (1) 190 Analysis of human synovial fluid phospholipase-A2 on short chain phosphatidylcholine- mixed micelles - Development of a spectro- photometric assay suitable for a microtiter- plate reader.

Nicollgriffith D, Zamboni R// Merck Frosst Ctr Therapeut Res, Dept Med Chem, POB 1005, Pointe Claire, Quebec, Canada H9R 4P8 PROSTAGLANDINS 1992,43 (6) 523 N-acetyl {H-3) leukotriene-D4 - A stable internal standard for automated bio-fast HPLC extraction and separation of LTE4 from human urine.

Puskas JD, Cardoso PFG, Mayer E, Shi SQ, Slut&y AS, Patterson GA*// *Washington Univ, 3108 Queeny Tower, 1 Barnes Hosp Plaza, St Louis, MO 63110, USA J THORAC CARDIOVASC SURG 1992, 104 (1) 83 Equivalent l&hour lung presenation with low-potassium dextran or Euro-Collins solu- tion after prostaglandin El infusion.

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TWICE MONTHLY BIBLIOGRAPHY ON PROSTAGLANDINS BIOLOGY- LATE SEPTEMBER PREPARED BY SHEFFIELD UNIVERSITY BIOMEDICAL INFORMATION SERVICE

SHEFFIELD SlO 2TN

1. BOORS, REVIEWS, SYMPOSIA Musser JH, Kreft AF// Glycomed Inc, 860 At- lantic Ave, Alameda, Ca 94501, USA J MED CHEM 1992,35 (14) 2501 S-lipoxygenase - Properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors (Review)

Bull HA, Dowd PM// Middlesex Hasp, UCMSM, Dept Dermatol, Mortimer St, Lon- don WlN 8AA, England PROSTAGLAND LEUK ESSENT FATTY 1992,46 ( 3) 167 Prostaglandin synthetase, interleukin-1 and inflammation in the skin (Review)

Kroegel C, Kortsik C, Kroegel N, Matthys H// Univ F&burg, Inst Med, Dept Pneumol, Robert Koch Clin, Hugstetter Str 55, W-7899 Freiburg, FRG - DRUG AGING 1992.2 (441345 The pathophysiological r&e and therapeutic implications of platelet activating factor in diseases of aging (Review)

3. PRECURSORS Oliw EH, Okamoto S, Homsten L, Sato F// Uppsala Univ, Ctr Biomed, Dept Pharma- ceut Pharmacol, POB 591, S-75124 Uppsala, Sweden BIOCHIM BIOPHYS ACIA 1992,1126 (3) 261 Biosynthesis of prostaglandins from 17(18)epoxy_eicosatetraenoic acid, a cytoch- tome-P-450 metabolite of eicosapentaenoic acid.

4. Arachidonic Acid Meers P, Mealy T, Pavlotsky N, Tauber Al N Boston Univ, Sch Med, Dept Pathol, William B Castle Hematol Lab, S-399, 80 E Concord St, Boston, Ma 02118, USA BIOCHEMISI’RY-USA 1992,31(28) 6372 Annexin I-mediated vesicular aggregation - Mechanism and role in human neutrophils.

Rosenthal MD, Lattanzio KS, Franson RC// Eastern Virginia Med Sch, Dept Biochem, POB 1980, Norfolk, Va 23501, USA BIOCHIM BIOPHYS ACTA 1992,1126 (3) 319 The effects of the phospholipaseA2 inhibitors aristolochic acid and PGBx on A23187- stimulated mobilization of arachidonate in human neutrophils are overcome by dia- cylglycerol or phorbol ester.

Roll FJ, Perez HD, Serhan CN// Univ Calif San Francisco, Dept Med, San Francisco, Ca 94143, USA BIOCHEM BIOPHYS RES COMMUN 1992,186 (1) 269 Characterization of a novel arachidonic acid- derived neutmphil chemoattractant.

Raynal P, Henegouwen PMPV, Hullin F, Ragabthomas JMF, Fauvel J, Verkleij A, Chao H*// l Hw Puman. INSERM. U326, F- 310;9 Toulouse; F&e BIOCHEM BIOPHYS RES COMMUN 1992, 186 (1) 432 Morphological and biochemical evidence for partial nuclear localization of annexin-l in endothelial cells.

Heinrothhoffmann I, Giessler C, Mest HJ // Martin Luther Univ, Dept Pharmacol & Toxi- col, 04020 Halle, FRG PROSTAGLAND LEUK ESSENT FATTY 1992,46(3)197 Relevance of vasoactive mediators for the blood pressure effects of intravenous arachidonic acid injection in rats.

Volterra A, Trotti D, Cassutti P, Tromba C, Salvaggio A, Melcangi RC, Racagni G// Univ Milan, Inst Pharmacol Sci, Ctr Neurophatma- col, Via Balzaretti 9, I-20133 Milan, Italy J NEUROCHEM 1992,59 (2) 600 High sensitivity of glutamate uptake to extrac- ellular free arachidonic acid levels in rat corti- cal synaptosomes and astrocytes.

Engels F, Renirie BF, Thart BA, Labadie RP, Nijkamp FP// Univ Utncht, Fat Pharm, Dept Pharmacol, POB 80082,3508 TD Utrecht, Netherlands FEBS LEIT 1992,305 (3) 2.54 Effects of apocynin, a drug isolated from the roots of Picrorhiza km-ma, on arachidonic acid metabolism.

Pentland AP, Morrison AR, Jacobs SC, HNT.~ LL, Hebert JS, Packer U/Washing- ton Univ, Sch Med, Dept Med, Div Derma- tol, 660 S Euclid, Box 8123, St Louis, MO 63110, USA J BIOL CHEM 1992,267 (22) 15578 Tocopherol analogs suppress arachidonic acid metabolism via phosophlipase inhibition.

Paver0 C, Bernard A, Carlier H*// ‘Univ Bourgogne, Ecole Natl Super Biol Appl Nutr & Alimentat, Dept Nutr, F-21000 Dijon, France J NUTR 1992, 122 (8) 1672 Administration modalities and intestinal lymph absorption of arachidonic acid in rats.

Swain LD, Schwartz Z, Boyan BD*// l Univ Texas, Hlth Sci Ctr, Dept Grthopaed, 7703 Fovd Curl Dr. San Antonio. TX 78284. USA BIbCHIM BiOPHYS AtiA 1992,1&i (1) 45 1,25-(OH)2D3 and 24,25-(OH)2D3 regulation of arachidonic acid turnover in chondro- cyte cultures is cell maturation-specific and may involve direct effects on phospholipase- A2.

Balsinde J, Femandez B, Solisherruzo JA, Diez w/ Hasp Univ Dote Octubte, Ctr In- vest. Maudes 60 2D. E-28933 Madrid. Suain BIdCHIM BIOPHYS ACTA 1992, i136 (1) 75 Pathways for arachidonic acid mobilization in zymosan-stimulated mouse peritoneal macrophages.

Scharping CE, McManus ME, Holder GM*// l Univ Sydney, Dept Pharm, Sydney, NSW 2006, Australia CARCINOGENESIS 1992,13 (7) 1199 NADPH-supported and arachidonic acid-sup ported metabolism of the enantiomers of trans-7,8dihydrobenzo[a]pyrene-7,8dio I by human liver micmsomal samples.

Petersgolden M, Cobum K, Chauncey JB// Univ Michigan, Med Ctr, Dept Internal Med, Div Pulm & Crit Care Med, 3916 Taubman Ctr, Ann Arbor, Mi 48199, USA

EXP LUNG RES 1992,18 (4) 535 Protein kinase-C activation modulates arachidonic acid metabolism in cultured alveolar epithelial cells.

Bonin SR, Phillips PP, McCaffrey TV*// *Mayo Clin & Mayo Fdn, Dept Otolaryngol, 200 1st SW, Rochester, Mn 55905, USA ACTA OTO-LARYNGOL 1992,112 (4) 697 The effect of arachidonic acid metabolites on the ciliary beat frequency of human nasal mucosa in vitro.

5. PROSTAGLANDINS E AND F Goss JA, Mangino MJ, Flye MW// Washing- ton Univ, Sch Med, Dept Surg, St Louis, MO 63110, USA J SURG RES 1992,52 (5) 422 Kupffer cell autoregulation of IL-1 ptoduc- tion by PGE2 during hepatic regeneration.

Rae MG, Rotondo D, Duttaroy AK*// ‘Ro- wett Res Inst. Div Biochem Sci. Bucksbum AB2 9SB, Aberdeen, Scotland BIOCHIM BIOPHYS ACTA 1992,1135 (3) 343 Regulation of prostaglandinE2 binding to a murine macrophage cell line, P388D1, by insulin.

Zacharieva S, Borissova AM, Andonova K, Stoeva I, Matrozov P// Acad Med Sofia, Inst Endocrinol & Gerontol. 6 Bd Cl&to Michai- lov, BU-1303 Sofia, Bulgaria HORMONE METAB RES 1992,24 (7) 336 Role of prostaglandin E2 (PGE2) on the cor- ticotropin-releasing hormone (CRH)-induced ACIH release in healthy men.

Takahashi K, Nammour TM, Fukunaga M, Ebert J, Morrow JD, Roberts W, Ho&er RL. Badr KF// Vanderbilt Univ. Med Ctr. Scd Med, Deit Med. S-3223 Mdd Ctr N, Nashville, Tn=37232,.USA J CLIN INVEST 1992.90 (1) 136 Glomerular actions of’s free’radical-gener- ated novel prostaglandin, 8epi-prostaglandin- F2 alpha, in the rat - evidence for interaction with thromboxaneA2 receptors.

Orlicky DJ, Fisher L, Dunscomb N, Miller GJ// Univ Colorado, Hlth Sci Ctr, Dept Pa- thol, 4200 E 9th Ave, Denver, Co 88262, USA PROSTAGLAND LEUK ESSENT FATTY 1992,46 ( 3) 223 Immunohistochemical localization of PGF2alpha receptor in the rat ovary.

Bry K, Hallman M// Univ Calif Irvine, Dept Pediat, Rm 109 F, Irvine, Ca 92717, USA AMER J OB!XET GYNECOL 1992,167 (1) 222 Transforming growth factor-beta opposes the stimulatoty effects of interleukin-1 and tumor necrosis factor on amnion cell prosta- glandit& production - implication for preterm labor.

Goss JA, Mangino MJ, Flye MW’, Zeppa R, Townsend CM, Paker G// l Washington Univ, Sch Med, Dept Surg, 1 Barnes Hcup PI, Suite 5108, St Louis, MO 63110, USA ANN SURG 1992,215 (6) 553 Prcstaglandin E2 production during hepatic

regeneration downregulates Kupffer cell IL.6 production.

Morikawa M, Aikawa T, Sekizawa K Ohrui T, Sasaki H, Takishima T// *Tohoku Univ, Sch Med, Dept Internal Med 1, Se-iryo Machi l-l. Aoba ku. Sendai. Mii 980. Janan EUR J PI-IA&&L i9!%, 217 (1 j 31 Inhibitory actions of prostaglandin-El on neurogenic plasma extravasation in rat air- Ways.

Suzuki S, Suzuki A, Kajikuri J, Itoh T// Kyushu Univ 60, Fat Med, Dept Neurosurg, Fukuoka 812, Japan EUR J PHARMACOL 1992,217 (1) 97 Endothelin-l-induced pmstaglandinE2 production - Modulation of contractile response to endothelin-1 in porcine coronary artery.

Elsharabasy MMH, Elnaggar MN// Mansou- ra Univ, Fat Sci, Dept Chem, Mansoura, EgyPt ACTA MED HUNG 1991,48 (34) 22.5 Prostaglandin-E2 in renal transplant reci- pients.

Fujimoto N, Kaneko T, Eguchi N, Urade Y, Mizuno N, Hayaishi O*// *Osaka Bicsci Inst, Dept Enzymes & Metab, 6-2-4 Furuedai, Suite, Osaka 565, Japan NEUROSCIENCE 1992,49 (3) 591 Biochemical and immunohistochemical dem- onstration of a tightly bound form of prosta- glandinE(2) in the rat brain.

Fan YY, Chapkin RS’N *Texas ACM Univ Syst, Dept A&m Sci, Molec & Cell Biol Grp, Colleee Stn. TX 77843. USA J NU?‘R 1992,122 (8j 1600 Mouse peritoneal macrophage ptostaglandin- El synthesis is altered by dietary gamma-linolenic acid.

Rastogi N, Bachelet M, Desousa JPCX Inst Pasteur, Unite TB & Mycobacteries, 2.5 Rue Dr Roux, F-75724 Paris 15, France FEMS MICROBIOL IMMUNOL 1992,89 (5) 273 Intracellular gmwth of Mycobacterium avium in human macrophages is linked to the increased synthesis of prostaglandin E2 and inhibition of the phagosome-lysosome fusions.

Alam M, Midtvedt T, Uribe A*// *Karolin- ska Inst, Danderyd Hasp, Dept Med, S-18288 Danderyd, Sweden EUR J GASTROENTEROL HEPATOL 1992,4 (7) 5.51 lndomethacin and prostaglandin-E2 induce trophic changes in the jejunal epithelium of germ-free rats by different cell kinetic mechanisms.

Uchida K, Ballermann B.l*// *Johns Hopkins Univ, Sch Med, Dept Med, Div Nephrol, 9 South, Ross Res Bldg, 720 Rutland Ave, Bal- timore, Md 21205, USA AMER J PHYSIOL 1992,263 (1) Pt 1, C2OO Sustained activation of PGE(2) synthesis in mesangial cells cocultured with glomerular endothelial cells.

Cudd TA, Wood CE*// l Univ Florida, Dept Physiol, Box 5274, JHMHC, Gainesville, Fl 32610, USA AMER J PHYSIOL 1992,263 (1) Pt 2, R136 Prostaglandin El2 releases ovine fetal ACIH from a site not perfused by the carotid vascu- lature.

Chatzipanteli K, Rudolph S, Axehod L*//

*Massachusetts Gen Hasp, Diabet Unit, Bos- ton, Ma 02114, USA DIABETES 1992,41(8) 927 Coordinate control of lipolysis by prostaglandin-E2 and prostacyclin in rat adipose tissue.

Thorbum GD// Monash Univ, Dept Physiol, Clayton, Vie 3168, Australia EARLY HUM DEV 1992,29 (l-3) 63 The placenta, PGE2 and parturition.

Imanishi M, Akabane S, Kawamura M, Mat- sushima Y, Kuramochi M, Omae T// Natl Cardiovasc Ctr. Div Hypertens & Renal Dis, S-7-1 Fujishiro Dai, S&a, Osaka 565, Japan KIDNEY INT 1992.42 12) 417 Angiotensin-II dk not 'increase renal prosta- glandinE2 in response to pressure reduction.

Gobbetti A, Zerani M, Botte V// Univ Ca- merino, Dept Molec Cellular & Anim Biol, Via F Camerini 1, I-62032 C&merino, Italy ZOOL SCI 1992,9 (3) 639 A possible involvement of prostaglandinE2 in the reproduction of female crested newt, Triturus carnifex.

6. PROSTACYCLIN Brunkwall JS, Stanley JC, Jackson T, Andem- son D, Bergqvist D// Univ Lund, Malmo Gen Hasp, Dept Surg, S-21481 Malmo, Sweden PROSI-AGLAND LEUK ESSENT FATTY 1992,46 ( 3) 175 Papaverine effects on PG12 and TXA2 release from *he canine vascular wall.

Watanabe K, Lam G, Jaffe EA// Fukuoka Univ, Sch Med, Dept Internal Med 2, Fukuo- ka 81401, Japan PROSTAGLAND LEUK ESSENT FATTY 1992,46 ( 3) 211 Tbe correlation between rises in intracellular calcium and PGI2 production in cultured vascular endothelial cells.

Elias M, Heethuis A, Weggemans M, Born V, Blom N, McShine RL, Halie MR, Sibinga CDS// POB 1191,970l BD Groningen, Netherlands ANN HEMATOL 1992,64 (6) 292 Stabilization of standard platelet concen- trates and minimization of the platelet stor- age lesion by a prostacyclin analogue.

Balint GA, Nafradi J// Albert Sxent Gyorgyi Med Univ, Dept Med 1, POB 397, Semelweis U 6, H-6701 Sxeged, Hungary ACTA MED HUNG 1991,48 (34) 189 Changes of mucosal endogenous prostacyclin level in human peptic ulcer disease - the role of smoking and sex difference.

Aliyev MA, Lemeshenko VA, Bekbolotova AK // Acad Sci KISSR, Inst High Elevat Physiol & Exptl Pathol, Bishkek, Kyrgyrstan KARDIOLOGNA 1992,32 (3) 67 Prcstacyclin-thromboxane imbalance in adrenergic cardac and aortic lesion and its correction with a calcium antagonist (Finop- tin) and adaptation to high-altitude climate (Russian)

Katircioglu SF, Kucukaksu DS, Bozdayi M, Saydam G, Zorlutuna N, Tasdemir 0, Bayaxit K// Turkiye Yuksek Thtisas Hosp, Cardiovasc Surg Clin, Biochem Clin, Ankara. Turkey VASC SURG 1992,26 (6) 464 Effects of pmstacyclin on heparin revemal with protamine (Russian)

Frolich Jc// Med Hseh Hatmover, Kim Phar- makol Abt, Postfach 610188, W-3888 Han- nover 61, FRG Z KARDIOL 1992,81(6) 383 Prostacyclin and hypertension (German)

Cano C, Qureshi Z Carter S. Malik KU*// *Univ Tennessee Ctr Hlth !I& Sch Med, Deot Pharmacol. 216 Crewe Bide 874 Union A&, Memphis, Tn 38163, USA -’ AMER J PHYSIOL 1992,263 (1) Pt 2, H218 Contribution of adenosine to isopmterenol- stimulated prostaqclin production in rabbit heart.

Furuhashi N, Tsujiei M, Kimura H, Yajima A// Tohoku Univ, Sch Med, Dept Obstet & Gynecol, Aobaku Seilyo Machi l-l, Sendai, Miyagi 980, Japan GYNECOL OBSTET INVEST 1992.33 (4) 193 Effects of exogenous pmstaqclin on placental blood flow. ~laceatal weinht and fetal weight in nor&en&e and “~ntaneously hypertensive rats.

Sowemimocoker SO, Haywood W, Heisel- man HJ, Francis RB*// *Univ So Calif, Sch Med, Dept Med, Raulston Bldg Room.322, 2025 Zonal Ave. Los Anaeks. Ca 90033. USA AMER J HEMkTOL 1!%2,& (4) 276 ’ Effects of normal and sickle erythroqtes on prostaqclin release by perfused human um- bilical cord veins.

Heyderman RS, Klein NJ// St Marys Hosp, Dent Paediat, Queen Bliibeth Queen Mother Wing, S Wharf Rd, London W2 lNY, England ARCH DIS CHILD 1992,67 (7) 980 Prostacyclin concentrations in haemolytic uraemic syndrome after acute shigellosis (Iet- ter)

7. THROMBOXANES Lei ZM, Rao CV*, Chakraborty c// l Univ Louisville, Hlth Sci Ctr, Sch Med, De.pt Ob- stet & Gynecol, 438 MDR Bldg, Louisville, Ky 40202, USA BIOL RBPROD 1992,47 (2) 233 Expression of thromboxane-A2 receptor gene and thromboxaneA2 synthase in bovine corpora lutea.

Amold JH, Pritchard KA, Greco NJ, Panga- namala RV*// *Ohio State Univ, Dept Med Biochem, 1645 Neil Ave, Columbus, Oh 43210, USA PROSTAGLAND LEUK ESSENT FATTY 1992,46 ( 3) 215 Production of platelet thromboxane-A2 and arterial prostaqclin-12 from hypercholeste- rolemic rats.

Nakahata N, Ishimoto H, Kurita M, Ohmori K, Takahashi A, Nakanishi I-I// Fukushima Med Sch, Dept Pharmacol, Fukushima 96012, Japan BRAIN RES 1992,583 (l-2) 100 The presence of thromboxane-A2 receptors in cultured astroqtes from rabbit brain.

Svane D, Skajaa K, Andersson KE, Forman A// Aarhus Kommune Hasp, Dept Obstet & Ginecol, Res Lab, DK-8000 Aarhus, Den- mark OBSTEI GYNECOL 1992,80 (2) 234 Effects of the thromboxane-receptor antagon, ists AH 23848 and BM 13.177 on human uteroplacental arteries.

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8. LEUKOTRIENES Vosc A, Reinhart M, Sprechcr H*// *Ohio State Univ, Dept Med B&hem, 337 Hamil- ton Hall, 1645 Neil Ave, Columbus, Oh 43210, USA BIOCHIM BIOPHYS ACI’A 1992,1127 (1) 33 Differences in the interconversion between 2Ocarbon and 22-carbon (n-3) and (n-6) polyunsaturated fatty acids in rat liver.

Muriana FJG, Ruizgutierrez V*, Vazquez CM// *CSIC, Inst Grass & Derivados, Apar- tado 1078, E-41012 Seville, Spain BIOCHIMIE 1992,74 (6) 551 Influence of dietary cholesterol on polyunsaturated fatty acid composition, fluidity and membrane-bound enzymes in liver microsomes of rats fed olive and fsh oil.

Brodowsky ID, Hamberg M, Oliw EH// Up- psala Univ, Ctr Biomed, Dept Pharmaceut Pharmacol, POB 591, S-75124 Uppsala, Sweden J BIOL CHEM 1992,267 (21) 14738 A linoleic acid (BR)-dioxygenase and hy- droperoxide isomerase of the fungus Gaeu- mannomyces graminis - biosynthesis of (8R)- hydroxylinoleic acid and (7S,8S)dihydroxyli- noleic acid from (SR)-hydroperoxylinoleic acid.

Hamberg M, Getwick WH, Asen PA// Karo- linska Inst. Dent Phvsiol Chem. Box 68408. S- 10401 Stockhoim 60: Sweden LIPIDS 1992,27 (7) 487 Linoleic acid metabolism in the red alga Li- thothamnion corallioides - biosynthesis of 11(R)-hydmxy-9(Z), 12(Z)-octadecadienoic acid.

Tocher DR, Mourente G, Sargent JR// Univ Cadiz, Fat Ciecias Mar, Dept Biol, Rio San Pedro, El1510 Puerto Real, Spain LIPIDS 1992,27 (7) 494 Metabolism of [1-C14ldocosahexaenoate (22/6N-3), [l-C-14jeicosapentaenoate (20/5N- 3) and [1-C-14llinolenate (18/3N-3) in brain cells from juvenile turbot Scophthalmus maxi- mus.

Ikeda I, Oka T, Koba K, Sugano M, Jie MSFLK// Kyushu Univ, Sch Agr, Nutr Chem Lab, 4609 Hakozaki, Fukuoka 812, Japan LIPIDS 1992.27 tn500 5c,llc,l4c-ei&sath&oic acid and 5c,llc,l4c,l7ccicosatetraenoic acid of Biota orientalis seed oil affect lipid metabolism in the rat.

Kendrick A, Ratledge C*// l Univ Hull, Dept Appl Biol, Hull HU6 7RX, N Humberside, England LIPIDS 1992,27 (7) 505 Phospholipid fatty aql distribution of 3 fungi indicates positional specificity for n-6 vs n-3 fatty acids.

Saynor R, Gillott T// No Gen Hasp, Shef- field Cardiothorac Lab, Sheftield S5 7AU, S Yorks, England LIPIDS 1992.27 (7’) 533 Changes in b&d‘li&Is and fibrinogen with a note on safety in a long term study on the effects of n-3 fatty acids in subjects receiving fish oil supplements and followed for 7 years.

Ringo E, Jostensen JP, Olsen RE// Univ Tromso, Norwegian Cdl Fihely Sci, Inst Biol & Geol, Dmmsveien 201, N-9801 Trom- so, Nonvay

LIPIDS 1992,27 (7) 564 Production of eicosapentaenoic acid by fresh- water Vibrio.

Calder JA, Schachter M’, Sever PS// *St Malys Hosp, Dept Clin Pharmacol, Queen Elizabeth Queen Mother Wing, London W2 lNY, England JPHARMPHARMA COL 1992,44 (7) 574 Interaction between cicletanine and the eicosanoid system in human subcutaneous resist- anfe arteries.

Dvorak B, Stepankova R// Inst Microbial, Dept Immunol & Gnotobiol, Videnska 1083, CS-14220 Prague, Czechoslovakia PROSTAGLAND LEUK ESSENT FATTY 1992,46 ( 3) 183 Effects of dietary essential fatty acid deficiency on the development of the rat thymus and immune system.

Marsen TA, Pollok M, Oette K, Baldamus CA// Univ Cologne, Dept Nephrol, Med 1 Clin, W-5000 Cologne 41, FRG PROSI-AGLAND LEUK ESSENT FATTY 1992,46 ( 3) 191 Phannacokinetics of omega-3-fatty acids during ingestion of fish oil preparations.

Osullivan BP, Mong S, Votta B, Schidlow DV// Univ Massachusetts, Med Ctr, Dept Pediat. 55 Lake Ave N. Worcester. Ma 01605,‘USA PROSI-AGLAND LEUK ESSENT FATTY 1992,46 ( 3) 203 Reduction of eicosanoid production by essential fatty acid depletion does not attenuate the inflammatoty response induced by Pseudomonas aeruginosa pneumonia in rat lung.

Das UN&gin ME, Ells G// Niims Inst Med Sci, Dept Med, Hyderabad 500482, India PROSTAGLAND LEUK ESSENT FATTY 1992,46( 3)235 Fatty acid changes during the induction of differentiation of human promyeloqtic leuke- mia (HL-60) cells by phorbolmyristate ace- tate.

Dtyden P, Allen B, Wong S, Reaney A, Mera- Ii T. Salari H// Univ British Columbia. Jack Fkll Res Ctr, Dept Med, 2668 Oak St,‘Van- cower, BC, Canada V6H 326 PROSTAGLANDINS 1992,44 (1) 11 Protein kinase-C impairs the coupling of the GTP-binding protein to LTB(4) receptor in neutrophil.

Myers SI, Hemandez R// Univ Texas, SW Med Sch, Dept Surg, 5323 Harty Hines Blvd, Dallas, TX 75235, USA PROSTAGLANDINS 1992,44 (1) 25 Role of oxygen-derived free radicals on rat splanchnic eicosanoid production during acute hemorrhage.

Ahmed A. Holton J, Vaira D, Smith SK, Hoult JRS// Middlesex Hosp, Dept Surg & Microbial. Mortimer St. London WIN SAA. England PROSTAGLANDINS 1992,44 (1) 75 Eicosanoid synthesis and Helicobacter pylori associated gastritis - increase in leukottiene- C(4) generation associated with H pylori col- onization.

Shaoira Y. Artru AA, Yadid G, Shohami E // &iv Washington, Sch Med, Dept Anes- thesiol. RN-IO. Seattle. Wa 98195. USA ANESI’H ANALG 1992, 75 (2) 238

Methylprednisolone does not decrease eicosanoid concentrations or edema in brain tissue or improve neurologic outcome after head trauma in rats.

Newton JF, Straub KM, Dewey RH, Percho- neck CD, McCarthy ME, Gleason JG, Lvrm RK// Smithkline Beecham Pharmaceut, Dept Drun Metab. Mail code L-721. POB 1539. Kingof Prussia, Pa 19406, USA ’ DRUG METAB DISPOSfTION 1992,20 (4) 479 Metabolism of the leukotriene receptor antagonist 5-(2-(8phenyloctyl)phenyl)-t,6dithian onanedioic acid (SK&F 102922) in the guinea pig - Rearrangement of the acyl glucuronide.

Izquierdo MS, Arakawa T, Takeuchi T, Ha- roun R, Watanabe T// Univ Las Palmas, Fat Ciencias Mar, Dept Biol, Tafira Baja, E- 35017 Gran Canaria, Spain AQUACULTURE 1992,105 (1) 73 Effect of n-3 HUFA levels in Artemia on growth of larval Japanese flounder (Paralich- thys olivaceus)

Scott DW, Miller WI-I, Decker GA, Wellins- ton JR// Cornell Univ, Coil Vet Ved, Dept- Clin Sci. Ithaca. NY 14853. USA CORNELL VI?T 1992,82’(3) 319 Comparison of the clinical efficacy of 2 com- mercial fatty acid supplements (EfaVet and DVM Derm caps), evening primrose oil, and cold water marine fish oil in the management of allergic pruritus in dogs - a double-blinded study.

Mosin VI, Yagoda AV// Govt Hosp, Dept In- ternal Dis, Safad, Israel HEPATO-GASI’ROENTEROL 1992,39 (3) 248 Synthesis of eicosanoids by circulating mono- nuclears in healthy people and in patients with liver cirrhosis.

Simopoulos AP, Norman HA, Gillaspy JE, Duke JA// Ctr Genet Nutr & Hlth, 2001 S St NW, Suite 530, Washington, DC 20009, USA J AMER COLL NUTR 1992,11(4) 374 Common purslane - a source of omega-3 fatty acids and antioxidants.

Meydani SN, Shapiro AC, Meydani M, Blum- berg JB// Tufts Univ, USDA, Human Nutr Res Ctr Aging, Nutr Immunol Lab, Boston, Ma 02111, USA J NUTR 1992,122 (8) 1627 Lung eicosanoid synthesis is affected by age, dietary fat and vitamin-E.

Meydani M, Meydani SN// Tufts Univ, USDA, Human Nutr Aging Res Ctr, 711 Washington St, Boston, Ma 02111, USA J NUT-R 1992, 122 (8) 1748 (n-3) fatty acids, tissue lipid peroxidation and tocopherol status (Letter)

Labbe MN/ Hlth & Welf Canada, Banting Res Ctr, Nutr Res Div, Micronutrients Sect, Ross Ave, Ottawa, Ontario, Canada KlA OL2 J NUTR 1992,122 (8) 1749 (n-3) fatty acids, tissue lipid peroxidation and tocopherol status - Reply.

Zambon S. Friday KE. Childs MT. Fuiimoto WY, Bierman EL, Ensinck JW*li ‘U(;iv Washineton. Med Ctr. Dent Med RC14. Div Endocriiol Metab Nutr, &attle, Wa 98i95, USA AMER J CLIN NUTR 1992,56 (2) 447 Effect of glyburide and omega3 fatty aicd

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dietary supplements on giucose and lipid me- tabohsm in patienta with non-insulindepend- ent diabetes-mellitus.

Kawada N, Klein H, Decker K*// *Univ Frei- burg, Inst B&hem, Hennann Herder Str 7, W-7888 F&burg, FRG BIOCHEM J 1992,285 (July) Pt 2,367 Eicoaanoid-mediated contractility of hepatic stellate cells.

Iawrence RH, Sorreli TCf/ Westmead Hosp, Ctr Infect Dis & Microbial. Westmead. NSW 2145, Australia CLIN EXP IMMUNOL 1992,89 (2) 321 Decreased poiymorphonuciear leucocyte chemotactic response to leukotrieneB4 in cystic fibrosis.

Ling BN, Webster CL, Eaton DC// Emoty Univ. Sch Med. Div Renal. 1364 Ciifton Rd NE, Atlanta, da 38322, USA AMER J PHYSIOL 1992,263 (1) Pt 2, Fl16 Eicoaanoids modulate apical Ca-2 + dependent K+ channels in cultured rabbit principal cells.

MacLouf J, Antoine C, Decaterina R, Sicari R, Murphy RC, Patrignani P, Loixzo S, Patm- no c// I&p Lariboihre, INSERM, U348,6 rue Guv Patin. F-75475 Paris 10. France AMEdJ PI-IYSIOL 1992,263 (i) Pt 2, H244 Entry rate and metabolism of leukotriene C- 4 into vascular compartment in healthy subjects.

Birch DG, Birch EE, Hoffman DR, Uauy RD /I Retina Fdn SW, Anderson Vis R& Ctr. Suite 400. 9900 N Cent Exowv. Dallas. TX 75231, USA

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INVEST OPHTHALMOL VISUAL SC1 1992,33(8)2365 Retinal development in vety-low-birth-weight infants fed diets differing in omega-3 fatty acids.

Proksch E, Feingold KR, Elias PM// Univ Kiel, Dept Dermatol, Schittenhelmstr 7, W- 2300 Kiel 1, FRG J INVEST DERMATOL 1992,99 (2) 216 Epidermal HMG CoA reductase activity in essential fatty acid deficiency - barrier m- quirements rather than eicosanoid generation regulate cholesterol synthesis.

9. PLATELET-ACTIVATING FACTOR Sugiura T, Fukuda T, Miyamoto T, Waku K N Teikyo Univ, Fat Pharmaceut Sci, Sagami- ko, Kanagawa 19901, Japan BIOCHIM BIOPHYS ACTA 1992,1126 (3) 298 Distribution of alkyi and alkenyi ether-linked phoapholipids and platelet-activating factor- like lipid in various species of invertebrates.

Bussolino F, Sironi M, Bocchietto E, Manto- vani A// Dipartimento Genet Biol & Chim Med, Via Santena 5 Bii, I-10126 Turin, Italy J BIOL CHEM 1992,267 (21) 14598 Synthesis of platelet-activating factor by polymorphonuclear neuttuphils stimulated with interleukin-8.

Domin J, Rozengurt E’N *Imperial Cant Res Fund, POB i23,44 Lincoins Inn Fields, London WC2A 3PX. Eneland J BIOL CHEM 1992,267 (21) 15217 Heterotogous desensitization of platelet- derived growth factor-mediated arachidonic acid release and prostaglandin synthesis.

Leong LLL, Sturm MI, Papadimitriou JM, Steohens CJ. TavIor RR*// l Roxal Perth H&, Dept ka&ol, Wel&to~ St, Perth, WA 6080, Australia J MOL CELL CARDIOL 1% 24 (6) 641 The effects of a PAP antagonist on ischemic myocardial damage and arrhythmia in the dog.

Podsiadiy BT, Adamson LM, Stanger JD, Smart YC, Roberts TK*// l Univ Newcastle, Dept Biol Sci, Univ Dr, Newcastle, NSW 2388, Australia MOL REPROD DEV 1992,32 (4) 363 Prefertiiixation treatment of mice with pia- telet activating factor affects pregnancy.

Lin CH, Wu YC, Lu ST, Haung TF, Teng CM’ /I *Nat1 Taiwan Univ, Coil Med, Inst Pharmacol, Taipei, Taiwan ASIA PAC J PHARMACOL 1992,7 (2) 121 Platelet-activating factor antagonism in rabbit platelets by the derivative of ochoten- simine isolated from Cotydalis ochotensis.

Pmshad M, Tomesch JC, Wareing JR, Lar- sen D. Defex H// Sandoz Pharmaceut Corn. Sandox Res Inst, 59 Route 10, E Hanover,* ’ NJ 07936, USA EUR J MED CHEM 1992,27 (4) 413 Synthesis and platelet activating factor (PAP) receptor antagonist activity of 2,5dia- tykyclopentanol derivatives.

Wong B, Tang W, Ziboh VA*// l Univ Calif Davis. Sch Med. Dent Dermatol. Davis. Ca 95616; USA - FEES LEIT 1992,305 (3) 213 Identification of a membrane-associated l-O- alkyd-2-arachidonoyi-sn-giycero-3-p hospho- choline hydrolyzing phospholipase-A2 in guinea pig-l epidermis - Implications in the cuta- neous biosynthesis of platelet-activating factor.

Gandhi CR, Debuysere MS, Olson MS// Univ Texas, Hlth Sci Ctr, Dept Biochem, San Antonio, TX 78284, USA BIOCHIM BIOPHYS ACTA 1992,1136 (1) 68 Platelet-activating factor-mediated synthesis of pmstagiandins in rat Kupffer cells.

Tufano MA, Tetta C, Biancone L, Iorio ELK, Baroni A, Giovane A, Camussi G*// *Osped Molinette, Cattedra Nefml, Immuno- patol Lab, C So Dogiiotti 14, Turin, Italy J IMMUNOL 1992,149 (3) 1823 Salmonella typhimurium porins stimulate platelet-activating factor synthesis by human polymorphonuclear neutmphils.

Bellan JA, Minkes RK, Hood JS, McMahon TJ. Hitruera TR. Nossaman BD. McNamara DB, &dowitx PJ*// *Tulane Univ, Sch Med, Dept Pharmacol, 140 Tulane Ave, New Or- leans, La 70112, USA AMER J PHYSIOL 1992,263 (1) Pt 2, H234 Analysis of pulmonary and systemic vascular responses to platelet-activating factor in the cat.

Kirsch CM, Bmkaw JJ, Prow DM, White GW // Santa Clara Valley Med Ctr, Div Rcsp Med, 751 S Bascom Ave., San Jose, Ca 95128, USA EXP LUNG RES 1992,18 (4) 447 Mechanism of platelet activating factor-induced vascular leakage in the rat trachea.

Ammit AJ, Wells XE, Oneill C*// *Royal N Shore Hasp, Human Reprod Unit, St Leo-

nards, NSW 2065, Australia HUM REPROD 1992.7 (61865 Structural heterogeneity &‘&&t-activating factor produced by murine preimplantation embryos.

10. METABOLITES Back F, Uematsu S, McCarmn RM, Spatx M*N l NINCDS, Stroke Branch, Bldg 36, Room 4D-04.9000 RockviUe Pike. Bethesda. Md 28892, USA PROSTAGLAND LEUK ESSEIVT FATTY 1992,46( 3)231 Pmstagiandin-D2 in cultured capilhuy and microvascular endothelium of human brain.

11. RELATED ENZYMES Queim Travarea JT de, Queirox Tavares D de, Miranda MAC de// Dept Quin Agr Solos, Eacola Agmnomia de Crux das Aimas, Univ Fed da Bahia, Bahia, Brazil ARQ BIOL TECNOL 1992,35 (1) 15 Lipoxygenase activity of IAC 8 descendants with -Ll, -L2 and -L3 soybeans (Portuguese)

Dupureur CM, Yu BZ, Jain MK*, Noel JP, Deng TL, Li YS, Byeon IJL, Tsai MD// *Ohio State Univ, Dept Chem, Columbus, Oh 43210, USA BIOCHEMISIRY-USA 1992,31(28) 6482 Phospholipase-A(2) engineering - Structural and functional mles of highly con=tved active site residues tyrosine-52 and tyrosine-73.

Osullivan MG, Chilton FH, Huggins EM, McCall CE// Wake Forest Univ, Med Ctr, Dept Med, Infect Dis Sect, Winston Salem, NC 27157, USA J BIOL CHEM 1992,267 (21) 14547 Lipopoiysaccharide priming of aiveolar mac- mphages for enhanced synthesis of prosta- noids involves induction of a novel prostagiandin-H synthase.

Gardiner IM, Li A, Pate1 N, Bail S, Debel- leroche J*// l Charing Cross & Westminster Med Sch. Deot B&hem. Fulham Palace Rd. London W6 8RF, England LIFE SC1 1992,51(8) PL77 Excitotoxin induction of omithine decarboxy- lase in cerebral cortex is reduced by phospholipase-A(2) inhibition.

Ensor CM, Tai HH*// l Univ Kentucky, Coli Pharm, Div Med Chem & Pharmaceut, Lex- ington, Ky 48536, USA PROSTAGLAND LEUK ESSENT FATTY 1992,46 ( 3) 219 Expression of the cDNA for NAD + dependent 15-hydmxyprostagiandin dehydmgenase as a catalytically active enzyme in Eacherichia coli.

Mibe M, Nagai K, Oshige T. Mori N// M+ki Mid Cell, Dept O&et & Gynecoi, Mivaraki 88916. Jaoan PROSI’AGtiLEUK ESSENT FATTY 1992,46(3)241 Endogenous inhibitors of human placental prostagiandin dehydmgenase.

Wennuth B// Univ Bern, Inselsoital. Dent Ciin Chem, CH-3010 Bern, Swi~erland - PROSTAGLANDINS 1992.44 (1) 5 NADPdependent 15-hydrc&p&&iandin dehydmgenase is homologous to NADde- pendent 15-hydroxypmatagiandin dehydmgenase and other short-chain alcohol dehy- dmgenases.

Beaver CJ, Murdoch WJ’// l Univ Wyoming,

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Dept Anim Sci, Laramie, Wy 82871, USA PROSTAGLANDINS 1992.44 (1) 37 Ovarian and uterine pro&land&-E(2)-9-ke- toreductase activity in cyclic and pregnant ewes.

Bennett PR, Henderson DJ, Moore GEII Univ London, Queen Charlottes & Chelsea Hosu. Roval Postttrad Med Sch. Inst Obstet & dy;lae&l, Lo&on W6 OXG,‘England AMER J OBSIET GYNECOL 1992,167 (1) 212 Changes in expression of the cyclooxygenase gene in human fetal membranes and placenta with labor.

Chupin W, Anikin MV, Serebrennikova GA, Margolin YM, Kreines VM, Ustyantse- va IM, Bulgakov VG, Shalnev AN// MV Lo- monosov Fine Chem Technol Inst, Moscow, Russia BIOL MEMBRANY 1992,9 (4) 349 Phospholipase-A2-membrane interaction - Effect of ether phosphatidylcholines on membrane stability and inflammatory processes (Russian)

Weisser B, Kayser G, Wagner S, Gobel BO, Vetter H, Dusing R*// l Univ Bonn, Med Po- liklin, Wilhelmstr 35-37, W-5300 Bonn 1,

E: J CLIN PHARMACOL 1992,42 (6) 681 Inhibition of cyclooxygenase attenuates ba- roreceptor function and increases the pressor response to norepinephrine in man.

Dhillon M, Roberts C, Nunn T, Kuo M// 105 Oak St, Binghamton, NY 13905, USA J ALLERG CLIN IMMUNOL 1992,90 (1) 42 Mapping human T-cell epitopes on phcs- pholipase-A2 - the major bee-venom allergen.

Hirashima Y, Farooqui AA, Mills JS, Hor- rocks IA*// *Ohio State Univ, Dept Med Biochem, 1645 Neil Ave, Columbus, Oh 43210, USA J NEUROCHEM 1992,59 (2) 708 Identification and purification of calcium-independent phospholipaseA2 from bovine brain cytosol.

Sessions RB, Dauberosguthorpe P, Campbell MM, Osguthorpe DJ*// l Univ Bath, Sch Chem, Molec Graph Unit, Claverton Down, Bath BA2 7AY, Avon, England PROTEIN-STRUCI FUNCT GENEI 1992, 14 (1) 45 Modeling of substrate and inhibitor binding to phospholipaseA2.

Yuan W, Wong CH*, Haeggstrom JZ, Wet- terholm A, Samuel&son B// l !Scripps Clin Br Res Inst. Dept Chem, lb666 N Torrey Pines Rd, La Jolla; Ca 92037, USA _ J AMER CHEM SOC 1992.114 (1616552 Novel tight-binding inhibitors of leukotriene- A4 hydrolase.

Vanderheijdt LM, Feiters MC, Navaratnam S, Nolting HF, Hermes C, Veldink GA*, Vliegenthart JFG// ‘Univ Utrecht, Bijvoet Ctr Biomolec Res, Dept Bioornan Chem, Pa- dualaan 8,3584 CH U&echt, N>therlands EUR J BIOCHEM 1992.207 (2) 793 X-ray absorption spectroscopy‘df soybean lipoxygenase-1 - Influence of lipid hydroperox- ide activation and lyophilization on the structure of the non-heme iron active site.

Akiba S, Kato E, Sato T*, Fujii T// ‘Kyoto

Pharmaceut Univ, Dept Biochem, Yamashi- na ku, Kyoto 607, Japan BIOCHEM PHARMA COL 1992,44 (1) 45 Biscoclaurine alkaloids inhibit receptor-mediated phospholipase&! activation probably through uncoupling of a GTP-binding protein from the enayme in rat peritoneal mast cells.

Tanaka K Matsutani S, Matsumoto K, Yoshi- da T*// l Shionogi & Co Ltd, Shionogi Res Lab, Fukushima ku, Osaka 553, Japan J ANTIBIOT 1992,45 (7) lb71 A novel type of phospholipase-A(2) inhibitor, thielocin Albeta, and mechanism of action.

Coyne DW, Nickels M, Bertrand W, Morri- son AR*// *Washington Univ, !Ich Med, Dept Molec Biol & Pharmacol, Box 8103, 660 S Euclid An, St Louis, MO 63110, USA AMER J PHYSIOL 1992,263 (1) Pt 2, F97 Regulation of mesangial cell cyelooxygenase synthesis by cytokines and glucocorticdids.

12. PRODUCTION AND RELEASE Modeer T, Anduren I, Lemer UH// Karolin- ska Inst. Fat Odontol, Dept Pedodont, Box 4064, S-14104 Huddinge, Sweden J ORAL PATHOL MED 1992.21(6) 2.51 Enhanced prostaglandin biosynthesis in human gingivat fibroblasts isolated from patients treated with phenytoin.

Tonshoff B, Momper R, Schweer H, Scharer K, Seyberth HW// Univ Heidelberg, Child- rens Hosp, Neuenheimer Feld 150, W-6900 Heidelberg, FRG PEDIAT RES 1992,32 (2) 137 Increased biosynthesis of vasoactive prosta- noids in Schonlein-Henoch purpura.

Ishihara 0, Khan H, Sullivan MHF’, Elder MG// *Hammetsmith Hosp, Royal Postgrad Med Sch, Inst Obstet & Gynaecol, Du Cane Rd, London W12 OHS, England PROSTAGLANDINS 1992,44 (1) 43 Interleukin-lbeta stimulates decidual stromal cell cyclooxygenase enzyme and prostaglandin production.

Zhang Z, Davis DU/ Kansas State Univ Agr & Appl Sci, Dept Anim Sci & Ind, Manhat- tan, Ks 66506, USA PROSTAGLANDINS 1992,44 (1) 53 Cell-type specific responses in prostaglandin secretion by glandular and stromal cells from pig endometrium treated with catccholestro- gens, methoxyestrogens and progesterone.

Akinlosotu BA, Guraya GN Tuskegee Univ, Sch Vet Med, Dept Physiol & Pharmacol, Tuskegee, Al 36888, USA THERIOGENOLOGY 1992,38 (1) 63 Regulation of in vitro progesterone release from caprine luteal tissues by prostaglandin- E2 and prostaglandinF2A.

Lundholm CE, Bartonek M// Fat Hlth Sci Linkoping, Dept Pharmacol, S-58185 Linkop- ing, Sweden ARCH TOXICOL 1992,66 (6) 387 Effects of p,p’-DDE and some other chlori- nated hydrocarbons on the formation of prostaglandins by the avian eggshell gland mucosa.

Smith RJ. Justen JM, Ulrich RG. Lund JE, Sam LM/> Upjohn Co, Dept Hypersensitiv Dis Res. Kalamazoo. Mi 49001. USA CLIN IMMUNOL IMMUNOPATH~L

1992,64 (2) 13.5 Induction of neutral proteinase and prostanoid production in bovine nasal chondrocytes by interleukin-1 and tumor necrosis factor- alpha - modulation of these cellular responses by interleukin-6 and platelet-derived growth factor.

Howard RW, Witters NA, Stanleysamuelson DW// USDA ARS, US Grain Mkt Res Lab, 1515 Coil Ave, Manhattan, Ks 66502, USA ANN ENTOMOL SOC AMER 1992,85 (4) 489 Phospholipid fatty acid composition and distribution patterns of prostaglandins in Mal- pighian tubules of the yellow mealworm (Co- leoptera, Tenebrionidae)

Thomas PS, Schreck RE, L.azarus SC*// l Univ Calif San Francisco. Cardiovasc Res Inst, San Francisco, Ca 94143, USA AMER J PHYSIOL 1992,263 (1) Pt 1, I.67 Tobacco smoke releases preformed mediators from canine mast cells and modulates prostaglandin production.

Magness RR, Rosenfeld CR, Faucher DJ, Mitchell MD// Univ Texas, SW Med Ctr, Dept Pediat, 5323 Harty Hines Blvd, Dallas, TX 75235, USA AMER J PHYSIOL 1992,263 (1) Pt 2, H188 Uterine prostaglandin production in ovine pregnancy - Effects of angiotensin-II and indomethacin.

13. EFFECTS Hardardottir I, Doerrler W, Feingold KR, Grunfeld C// Univ Calif San Francisco. Deut Med, San Francisco, Ca 94143, USA ’ 1 BIOCHEM BIOPHYS RES COMMUN 1992,186 (1) 237 Cytokines stimulate lipolysis and decrease li- poprotein lipase activity in cultured fat cells by a prostaglandin independent mechanism.

Bjomsson OG, Sparks JD, Sparks CE, Gib- bons GF*// *Radcliffe Infirm, Metabol Res Lab, Woodstock Rd, Oxford OX2 6HE, Eng- land J LIPID RES 1992,33 (7) 1017 Prostaglandins suppress VLDL secretion in primary rat hepatocyte cultures - relationships to hepatic calcium metabolism.

Hardcastle J, Hardcastle PT// Univ Sheffield, Dept Biomed Sci, Sheffield SlO 2TN, S York- shire, England J PHARM PHARMA COL 1992,44 (7) 603 Failure of tetrodotoxin to inhibit the prostaglandin-induced secretory response of rat small intestine invitro.

Sorokin G, Grant NM, Egan BM, Lombard JH’// l Med Coil Wisconsin, Dept Physiol, 8701 Watertown Plank Rd, Milwaukee, Wi 53226, USA AMER J OBSTEI GYNECOL 1992,167 (1) 110 Cyclooxygenase products do not modulate angiotensin-II induced contractions of human chorionic plate arteries.

Omar HA, Figueroa R, Omar RA, Tejani N, Wolin MS*// ‘New York Med Coil, Dept Phvsiol. Valhalla. NY 10595. USA AMER J OBSI’l?T GYNECOL 1992,167 (I) 201 Hydrogen peroxide and reoxygenation cause ptostaglandin-mediated contraction of human placental arteries and veins.

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Pshennikova MG, Kuxnetaova VA, KopyIov YN, Shimkovich MV, Vovk VI, Saptygin DV, Meerson IVY/ Acad Med Sci USSR, Gen Pa- thol & Pathol Physiol Res Ittst, Moscow, Rus- sia KARDIOLQGIYA 1992,32 (3) 61 Role of pmstagIandin system in the cardio- protective action of hypotic adaptation in stress (Russian)

Niethammer JG, Rule KA*, Larch V, Ander- son Mu/ l Univ Tennessee, Med Ctr, Dept Radio& Div Neonatol, 1924 Alcoa Highway, Knoxville, Tn 37928, USA AMER J PERINATOL 1992,9 (4) 279 Perioateal reaction induced by prostaglandins.

Adie ET. Mullaney I, McKenzie FR, Mill&an G*// l Uhiv Glasgow, Dept Biochem, Mot& Phannacol Gm. Glaseow G12 8QQ. Scotland BIOCHEM J ib92,2& (July) Pt 2,529 Concurrent down-regulation of IP pmstanoid receptors and the alphasubunit of the stimu- latory guanine-nucleotide-binding protein (GS) during prolonged exposure of neuro- blastoma x ghoma ceils to prostanoid agon- ists - Quantification and functional implications.

Goureau 0, Tanfin 2, Marc S, Harbon S’// ‘Univ Paris 11, Endocrinol & Regulat Cellu- laires Lab, CNRS, URA 1131, Bat 432, F- 91405 Orsay, France AMER J PHYSIOL 1992,263 (1) Pt 1, C257 Diverse prostaglandin receptors activate distinct signal transduction pathways in rat myometrium.

14. PROSTAGLANDINS IN MEDICINE Watkinson AC, Bunge AL, Hadgraft JO// ‘Univ Wales Coil Cardiff. Welsh Sch Pharm, POB 13, Cardiff CF13XF, Wales INT J PHARM 1992,83 (l-3) 171 Aspects of the transdermal delivery of prostaglandins. 2.

Krasnikova TL, Minchuna VP, Runikhin AY, Arab&e GG. Mazaev AV. Yudavev AD// Acad Med Sci USSR Cardiol Rg Ctr, Mos- cow, Russia KARDIOLOGIYA 1992.32 (2) 36 Regulation of lymphocyte ad&late cyclase system in patients with therapy-refractory arterial hypertension during PGE2 administration (Russian)

15. PROSTAGLWDINS AS DRUGS Thong IU, Robertson AI, Baird DT// Univ Edinburgh, Ctr Reptod Biol, Dept Obstet & Gynaecol, 37 Chalmers St, Edinburgh EH3 9EW, Scotland PROSIAGLANDINS 1992,44 (1) 65 A retrospective study of 932 2nd trimester terminations using gemepmst (16,16 dimethyl-ttans delta-(2)PEG(l) methyl ester)

Thong KJ, Baird DT// Univ Edinburgh, Ctr Reprod Biol, Dept Obstet & Gynaecol, 37 Chalmers St, Edinburgh EH3 9EW, Scotland CONTRACEPTION 1992,46 (1) 11 A study of gemeptost alone, dilapan or mifepristone in combination with gemeprost for the termination of second trimester pregnancy.

Burk SA, Mentx P// Martin Luther Univ, Inst Pharmacol & Toxicol, Klin Pharmakol Abt, Leninallee 4, 04020 Halle, FRG ARZNEIM-FORSCH-DRUG RES 1992,42-

Effects of indometacin and ilopmst on the cardiodepressant properties of various narco- tics on isolated auricle preparations from guinea pigs (German)

Takeuchi K, Suzuki S, Kako N, Kobayashi M, Takahashi S, Sawada M, Honma T, Iwabuchi S, Fukui K, Koyama K et aI// Childrens Hosp Pittsburgh, Rm 4B465, Pittsburgh, Pa 15213, USA ANN THORAC SURG 1992,54 (2) 327 A prostacyclin analogue reduces free radical generation in heart-lung transplantation.

16. INHIBITORS OF SYNTHESIS CrawIev GC, Dowell RI, Edwards PN, Foster SJ, Me&an RM, Walker ERH, Waterson D. Bird TGC. Bruneau P. Girodeau JM// ICI Pharmaceut Plc, Dept Chem 1, Macclesfield SK10 4TG, Cheshire, England J MED CHEM 1992,35 (14) 2600 Methoxytetrahydropyrans - A new series of selective and orally potent S-lipoxygenase inhibitors.

Vickers PJ, Adam M, Charleson S, Coppoli- no MG, Evans JF, Mancini JA// Merck Frosst Ctr Therapeut Res, Dept Pharmacol, POB 1005, Pointe Claire, Quebec, Canada H9R 4P8 MOL PHARMACOL 1992,42 (1) 94 Identification of amino acid residues of S-lipoxygenase-activating protein essential for the binding of leukotriene biosynthesis inhibitors.

Bjoro T, Larsen V, Englund K, Torjesen PA, Haug E// Univ Oslo, Aker Hosp, Hormone Lab, N-0514 Oslo 5, Norway SCAND J CLIN LAB INVESI 1992,52 (4) 297 The lipoxygenase inhibitor nafazatrom inhibits stimulated prolactin secretion in cultured rat lactotrophs (GH4Cl cells)

Marien K, Mot-ten M, Degreef H, De- doncker P, Rooman RP, Cauwenbergh G// Catholic Univ Leuven, Dept Dermatol, B- 3000 Louvain, Belgium ARCH DERMATOL 1992.128 f7) 993 Treatment of hyperkeratotic skicin‘&eases with R-68151, a topical S-lipoxygenase inhibitor - four case reports.

Abraham WM, Ahmed A, Cortea A, Sielczak MW, Hinz W, Bouska J, Lanni C, Bell RIJ/ Mt Sinai Med Ctr, Harty Pearlman Biomed Res Inst, Dept Res, 4300 Alton Rd, Miami, Fl33140, USA EUR J PHARMACOL 1992,217 (2-3) 119 The S-lipoxygenase inhibitor zileuton blocks antigen-induced late airway responses, inflammation and airway hyperresponsiveness in allergic sheep.

Parodi MC, Cognein P, Fazzuoli L, Sacco T// Osped S Martin0 Monoblocco, Div Gastroen- terol, Viale Benedetto XV, 1-16132 Genoa, Italy CURR THER RES 1992,52 (1) 13 Effects of omeprazole on gastric mucus secretion, tissue prostagtandin synthesis, and acid inhibition in patients with duodenal ulcer - comparison with ranitidine treatment.

Boschelli DH, Connor DT, Kuipers PJ, Wright CD// Warner Lambert Parke Davis, Parke Davis Pharmaceut Res Div, Dept Chem, 2800 Plymouth Rd, Ann Arbor, Mi 48105, USA

BIORG MEDICINAL CHEM LEITER 199%2(7)705 Synthesis and cyclooxygenase and S-lipoxygenase inhibitory activity of some thiazolidene- rl-one analogs of meclofenamic acid.

Voss C, SepuIvedaboxa S, Z&ken FW// Univ Bonn, Inst Physiol Chem, Numallee 11, W-5388 &M 1, FRG BIOCHEM PHARMA COL 1992,44 (1) 157 New isoflavonoids as inhibitors of porcine 5- lipoxygenase.

Endredi J, Elkashef HA, Hofman WF’, Ehrhart IC// l Med Coil Georgia, Dept Physi- 01 & Endocrinol, Augusta, Ga30912,-USA PHARMACOLOGY 1992.44 16) 306 Effects of different cycloox&et&e inhibitors on the segmental distribution of pulmonary vascular resistance in the dog.

Pospisil M, Hofer M, Pipalova I, Vikhcka S, Netikova J, Sandula J// Czechoslovak Acad Sci, Inst Biophys, Kralovopolska 135, CS- 61265 Bmo, Czechoslovakia EXP HEMATOL 1992,20 (7) 891 Enhancement of hematopoietic recovery in gamma-irradiated mice by the joint use of di- clofenac, an inhibitor of prostaglandin pro duction, and glucan, a macrophage activator.

Keith J, Rowles T, Warwick K, Yau I!!// Virgi- nia Polytech Inst & State Univ, Virginia Ma- @and Reg Coil Vet Med, Dept Biomed Sci, Blacksburg, Va 24061, USA TERATOLOGY 1992,46 (2) 159 Effects of a 48 hour continuous intravenous infusion of CGS 130&t-primagrel, a se.lective thromboxane synthetase inhibitor, on the perinatal and early postnatal period in the guinea pig.

18. CHEMICAL SYNTHESIS Dikovskaya KI, Mazur TV, Turovskii IV, Ga- vats NP, Freimanis YF// Latvian Acad !Ici, Inst Organ Synth, Rip 22&X& Latvia KHIM GEIEROTSIKL SOEDIN SSSR 1991 (12) 1621 Total synthesis and properties of prostaglandins. 30. Moditication of (lSJR)2oxabicy- clo[3.3.0]-6-octen-3-on e at alpha-carbon (Russian)

19. TECHNIQUES Cboney SJ, Smal MA, Bald0 BA*// *Royal N Shore Hasp, Kolling Inst Med Res, St Leo nards, NSW 2065, Australia J IMMUNOL METHOD 1992,151 (l-2) 131 Measurements of PAF in blood by tadioim- munoassay - examination of interfering fac- tors and problems invohred in accurate quantification.

20. FORTHCOMING EVENTS 12th Joint Meeting of British Endocrine So- cieties, Liverpool, United Kingdom. 29 March - 1 April 1993. Further details available from: Janet Cromp ton, Admin Officer, British Endocrine So- cieties, 17/18 North Court, The Courtyard, Woodlands, Almondsbury, Bristol BS12 4NQ, United Kingdom. Tel. (0)454 616846. Fax. (0)454 616071

The bibliography which appears in this journal is also available cm subscription, on a fortnightly basis, from Sheffield University Biomedical Information Setice. Sheffield SlO 2TN. UK. It is entitled ‘Prostaglandius - Biology’ (ISSN 0142-8284) and costs E76.00 (also available on diskette at E60.00).

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Monthly prostaglandin bibliography prepared by the University of Sheffield Biomedical Information...

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