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17
Protective Effects of Garlic Powder on the Performance of Testosterone- Induced Cardiac
Hypertrophy in Rats
Shackebaei D1, Gorgani R
2, Hesari M
1, Bahrami GH
1, Kiani A
3
1Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
2Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
3Tissue Engineering and Regenerative Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Corresponding Author: Hesari M, Medical Biology Research Center, Kermanshah University of Medical Sciences,
Kermanshah, Iran
E-mail:[email protected]
Received: 29 Dec 2016 Accepted: 28 May 2017
Background and Objective: The androgens cause the cardiac hypertrophy and cardiomyopathy. There are
reports of garlic protective effects in the cardiac hypertrophy due to overload and catecholamine. The aim of
this study was to investigate the effects of garlic powder on testosterone-induced cardiac hypertrophy in rats.
Materials and Methods: This experimental study was performed on Wistar male rats in 5 groups (n = 7-8)
including the testosterone group (10 mg testosterone enanthate for 20 days), the garlic group (1.6 g for 10
days), the control garlic group and finally the garlic + testosterone. The separated hearts were perfused
according to Langendorff method and passed three basal, ischemia and reperfusion stages. The structural and
functional parameters of left ventricular fluctuations (LVDP), ventricular contractility (dp / dt) and rate
pressure product (RPP) were measured.
Results: In the testosterone-induced hypertrophy group, the cardiac weight, the thickness of the left
ventricular wall and the functional parameters of the heart, such as LVDP, RPP, + dp / dt, and -dp / dt
indicated significant increase. The use of garlic powder in the base period led to a significant decrease in
these parameters (P <0.05). However, in the period of ischemic reperfusion, the effect was not significant.
Conclusion: The results showed that the garlic powder modifies the cardiac hypertrophy induced by
testosterone administration in rats. In other words, the use of garlic powder could potentially reduce the
severity of cardiac hypertrophy in rats, due to variations in functional and structural parameters.
Key words: Garlic, Cardiac Hypertrophy, Testosterone, Ischemia / Reperfusion, Rat
