NANO BASED POLYMERS AND APPLICATIONS(DRUG DELIVERY)

Presented By:Mr. Anil KumarM.Phil./ Ph.D. Nano-science (2012-13)Centre for Nano-scienceCentral University of Gujarat

NANO POLYMERS FORMATION

Bulk Material

Macro Micro Nano

MoleculesMonomers units

Å

NanoPolymers

Small Bulk Materialor Micro Polymers

Å

Bottom Up Approaches Top Down Approaches Nano

Lysis of Bulky Materials:- Synthesis of Materials (Nano Composites):- 1. Chemolysis. (Use

organic solvents )2. Thermolysis. (ΔG = ΔH –

TΔS)3. Radiation. (Break

chemical bonds, phenolic , polystyrene)

4. Diffusion. (stirrer with high speed)

5. Enzymolysis. (cellulase, pectinase, ribulase..etc.)

6. Biodegradation. (bacteria, fungi, algae ..etc.)

1. Self Assembling. (Inter or Intra Molecular Interaction)

2. Crystallization. ( Solid and Liquid )

3. Precipitation. ( Liquid and Liquid recovery of salt and metals)

4. Sol-Gel. (NM + Organic Solvent + Gel)

5. Molecular Interaction.(Ionic Interaction)

6. Biosynthesis. (Recovery of molecules)

Nan

o p

oly

mers

Techniques Applied formation To Nano

Polymers

Model of Surface-to-volume Comparisons…

Neglecting spaces between the smaller boxes, the volumes of the box on the left and the boxes on the right are the same but the surface area of the smaller boxes added together is much greater than the single box.

Single Box Ratio6 m2

1 m3 = 6 m2/m3

Smaller Boxes Ratio12 m2

1 m3 = 12 m2/m3

PROPERTIES

Structural :- Platelets, Fibers, Spheroids, Linear, Branch, Network..etc. Physical & Chemical:- Like as Stiffness, Strength, Stability, etc. (2D,3D).

Typical Structures are:

• Linear (end-to-end, flexible) .

• Branched(one end free, other attached to stalk polymer).

• Network (similar to highly cross-linked structures,termosetting polymers).

Polymer has a Multidisciplinary Field of Science & Technology

Nano Based Polymers TypesChemical Synthetics- Polyglycolic acid (PGA)- Polylactic acid (PLA)- PGA-PLA- Polydioxanone (PDO)- Polycaprolactone- PGA-polycaprolactone- PLA-polycaprolactone- Polydioxanone-polycaprolactoneNatural- Elastin- Gelatin collagen- Fibrillar collagen- Collagen blends- Fibrinogen- Heamoglobine

NANO BASED SOME POLYMERS AND APPLICATIONBroad Fields Nano Size Polymers Applications

Chemicals PVC. (Poly vinyl chloride) Raincoats, shower curtains, water pipes PMMA. (Poly methyl

methacrylate)

Plastic base glasses

PE. (Polyethylene) Grocery bags, shampoo, bottles, children’s toys, bulletproof vests

PS. (Polystyrene) Comb, TVs body,. radio knobs. drinking cups foamy PP. (Polypropene) packaging, textiles (e.g. ropes, thermal underwear,

carpets), stationery, plastic parts laboratory, equipment, loudspeakers,

PPS. (Poly phenylene sulfide)

Resist chemical and thermal attacks

ABS. (Poly acrylonitrile butadiene styrene)

Very strong and lightweight polymer. It is strong enough to be used to make automobile body parts

PNBR. (Polymer Nitrile Buna-N rubber)

Cleaning of lab equipment, sophisticated, instruments and examination gloves.

Biological Immunogenic Immunoglobulin (IgA, IgD, IgE, IgG, IgM) Antigenic Epitope, Motifs, TCR (CD4,CD8), MHC

Lipids Emulsions Mixture (HC+H2O) Liposomes Micelle, Amphipathic

Metals Nanoshell Cover (Sphere) of NP Nanocomposites NP + Polymer

Fibers Nanosphere Careers Nanoparticles(amino, carboxyl, surfaces) Nanocapsule Fiber Coat (Medicine coat, cover)

Outline Process of Nano-Vector

Nano polymer mostly can be very effective to be Designing a Drug as name “NANO VECTOR” by using of Nano Polymers and Nano Materials in size nano range and also Applied for induced tumor cells available in Critical Organs of Body such as Brain, Lung, Heart...etc. These vector designed a typical types, who are search to target site, that target site a specific receptor Presented in outer cell membrane of the tumor cell receptor made be become Biomolecules it bind by various ways and released to NP into tumor cells. Where It are do The tumor Cells Remove or Destroyed as may be possible without surgery Because Some Tumor Cell have arises to another Tumor Cell by Cell Cycling, here break Cell Cycling by This Nano Vector will as a processing inhabit of protein synthesis of tumor cell.

DNA Strand in nm

Nano-Vector

DNA Strand

Nano-Vector

Nanoparticle (Drugs)

DNA Strand

Nano-Vector

Nanoparticle (Drugs)

Covering of NP by DNA Polymer

DNA Strand

Nano-Vector

Covering of NP by DNA Polymer

Covered of NP by DNA Polymer

Nanoparticle (Drugs)

DNA Strand

NP

vector with Drugs

vector with Drug

Moieties Target (Receptors)

Nanovector with Durg

Moieties Target (Receptors)

vector with Durg

Moieties Target (Receptors)

vector with Durg

Moieties Target (Receptors)

Nano vector with various moiety receptors

Assembled Nano Vector (Drug)

Thank You for a kind Attention