02/05/2023

1

02/05/2023

NASAL DRUG

DELIVERY SYSTEM

2

02/05/2023What is Nasal Drug Delivery

System ?

3

02/05/2023

4

NASAL DRUG DELIVERY SYSTEM ..• Administration of drug through nasal route is known

as Nasal Drug Delivery System .• About 2% of the overall drug delivery is via the nasal

route .• In recent years many drugs have been shown to

achieve better systemic bioavailability through nasal route than by oral administration .

• Eg : topical decongestants and anti inflammatory drugs used in rhinitis .

• Nasal route is an alternative to invasive administrations and provides a direct access to the systemic circulation.

02/05/2023

5

02/05/2023

6

02/05/2023

7

THE NOS

E

02/05/2023

8

NASAL pH•Nasal secretion of adult : 5.5 -6.5•Infants and children : 5-6.7•It becomes alkaline in conditions such as

acute rhinitis. ,acute sinusitis .

02/05/2023

9

FUNCTIONS OF NOSE

OLFACTION

•SMELL DETECTION

RESPIRATION

•FILTRATION•HEATING •HUMIDIFICATION

02/05/2023

10

02/05/2023

11

02/05/2023

12

02/05/2023

13

MECHANISM OF NASAL

ABSORPTION

02/05/2023

14

02/05/2023

15

02/05/20233.16

02/05/2023

17

02/05/2023

18

4.)DIRECT ABSORPTION INTO THE BLOOD STREAM•Large mucosal surface covered with a

rich vascular bed of highly permeable capillaries creates an opportunity for intranasal medication delivery .

•Not just fluids but the fluids delivered in air stream onto the mucosa will cross the capilary bed into the airstream .

02/05/2023

19

FACTORS AFFECTING NASAL DRUG DELIVERY

02/05/2023

• EFFECT OF MOLECULAR SIZE AND WEIGHT .

• EFFECT OF PERFUSION RATE .• EFFECT OF PERFUSATE VOLUME .• EFFECT OF SOLUTION.• DRUG LIPOPHILICITY .• DRUG CONCENTRATION .• DRUG SOLUBILITY AND DISSOLUTION

RATE .

PHYSIOCHEMICAL PARAMETERS

• TRANSCELLULAR• PARACELLULAR ETC .

MECHANISMS

• MODE OF ADMINISTRATION .DISTRIBUTI

ON AND DEPOSITION

20

02/05/2023•Structural modification•Salt/ester formation•Formulation design•surfactants

ENHANCEMENT IN

ABSORPTION

EFFECT OF DELIVERY SYSTEM

PHARMACOKINETICS AND BIOAVAILABIL

ITY

21

02/05/2023

22

THERAPEUTIC CLASS OF DRUGS FOR NASAL ROUTE .

1. ß2 Adrenergic agonists .2.Corticosteroids . 3.Antiviral .4.Antibiotics .5.Antifungal .6.Vaccines (recently)

02/05/2023

DOSAGE FORMS

NASAL DOSAGE FORMS

23

02/05/2023

24

•INSUFFLATORS .•DRY POWDER INHALER

POWDERS

02/05/2023

25

02/05/2023

26

02/05/2023

27

02/05/2023

28

02/05/2023

29

02/05/2023

30

NASAL CREAMS•Nasal creams are semisolid preparations

that meant to be instilled in the nose.•They are cost effective , non invasive .

02/05/2023

31

NASAL OINTMENTThese are translucent ,homogenous ,

viscous ,semisolid preparation intended to be instilled in the nose .

They are easy to administer

and painless.

Due to their viscosity they will not ooze out of the nose

02/05/2023

32

SATURATED COTTON PLEDGET.

•Cotton pledgets are soaked in the drug and placed in the nasal cavity .

•Commonly used for local anaesthetics ,vasoconstrictors etc .

02/05/2023

33

02/05/2023

34

02/05/2023

35

Mucosal atomization is the best method because :cheapeasy to useDisposable / single useAppropriate drug concentrations

02/05/2023

36

Nebulizer is a drug delivery device used to administer medication in the form of a mist inhaled into the lungs.The most commonly used nebulizers are Jet nebulizers, which are also called "atomizers". Jet nebulizers are commonly used for patients in hospitals who have difficulty using inhalers .The main advantage of the Jet nebulizer is related to its low operational cost.

NEBULIZERS

02/05/2023

37

POWDERS

LIQUID DROPS

LIQUID SPRAY/NEB

ULIZER

AEROSOLS

SUSPENSION SPRAY/NEBU

LIZERS GELOINTME

NTSCREAM

S

02/05/2023

38

RECENT ADVANCE

S

02/05/2023

39

NASAL INSULIN•Several trials are made with intranasal

formulations.•DESMOPRESSIN was the first drug given

nasally.•Its available as insufflator ,nasal kit etc .

02/05/2023

40

02/05/2023

41

02/05/2023

42

NASAL ANTI VOMITINGLINCOLN PHARMA :• Presently in india , anti vomiting agents are

available in the form of tablets and injections which take longer time to provide relief .

•But now through nasal drug delivery system , the patient can get immediate relief .LPL

becomes the first company in India to provide anti vomiting drug in the form of nasal spray

pump .

02/05/2023

43

02/05/2023

44

02/05/2023

45

02/05/2023

46

02/05/2023

47

02/05/2023

PRESENTED BY : RAKHI NAIR V

1ST M PHARM

48

02/05/2023

49