National Pharmacology Quiz 2011

Theme

Experience the Ecstasy

Round 1

Choice is Yours

Rules for Round 1Each team has to select a system (shown in next slide).

Five questions will be asked in the selected system to every team.

You have 30 seconds to answer each question.

Ten points for answering correctly. No negative marks for wrong answer.

Unanswered / wrongly answered questions do not pass to the next team.

Questions in the systems not selected by any team will be used as tie breaker (if needed)

Autonomic Nervous System

Blood & Autacoids

Cardiovascular System

Central Nervous System

Endocrinology Chemotherapy

Autonomic Nervous System

1. Which system is considered as the third division of autonomic nervous system?

Enteric nervous system

2. Which blocker can augment the effects of tricyclic antidepressants by blocking negative feedback of 5HT on 5HT1A autoreceptors?

Pindolol

3. Which partial agonist (ANS drug) is associated with suicidal ideation?

Varenicline

4. Which 2 agonist is used for sedation in intensive care setup & during anaesthesia?

Dexmedetomidine

5. Which appetite suppressant was removed from market as it was associated with hemorrhagic stroke in young women?

Phenylpropanolamine

Blood & Autacoids

1. Which structure / organelle concentrates serotonin by active transporter?

Platelets

2. Which iron preparation is associated with soft tissue sarcomas?

Intramuscular iron sucrose

3. Which drug inhibits the final common pathway of platelet aggregation?

Gp IIb / IIIa inhibitors (Abciximab, eptifibatide,

tirofiban)

4. Which form / salt of Vitamin K should never be used in therapeutics?

Vitamin K3 - Menadione

5. Which is the most effective drug for increasing HDL?

Niacin

Cardiovascular System

1. Which group of antihypertensives can cause both hyperglycemia and hypoglycemia?

Beta blockers

2. Even though this agent is labeled as Class III antiarrhythmic, it also displays Class I, II and IV activity. Name this drug.

Amiodarone

3. Which vasoconstrictor is preferred over adrenaline for use along with local anaesthetic in patients with cardiovascuar disorders?

Felypressin

4. Which drug reduces total peripheral resistance, requires a blocker to counteract reflex tachycardia & may cause drug induced lupus?

Hydralazine

5. What is the mechanism of action of ticagrelor?

Reversible inhibition of ADP receptor (P2Y12)

Central Nervous System

1. Name the opioid which has anticholinergic properties.

Pethidine (Meperidine)

2. Which inhaled anaesthetic has the lowest blood gas partition coefficient and thus produces rapid onset and offset of effect?

Desflurane

3. Name the antiparkinsonian drug which yields amphetamine as its metabolite.

Selegiline

4. Which antiepileptic causes loss of hair which grows back curly?

Sodium valproate

5. Acute intoxication of this CNS drug inhibits drug metabolising enzymes whereas chronic administration induces them. Identify this drug.

Ethanol

Endocrinology

1. Which endocrine agent is used to reverse the cardiac effects of beta blocker toxicity?

Glucagon

2. Which drug activates the calcium sensing receptor and blocks parathormone secretion?

Cinacalcet

3. Name the pure estrogen receptor antagonist used in breast cancer resistant to tamoxifen.

Fulvestrant

4. Which inhaled corticosteroid is a prodrug activated by esterases in bronchial epithelium?

Ciclesonide

5. Name the antidiabetic drug whose discovery was based on substances obtained from Galega officinalis?

Metformin

Chemotherapy

1. Which beta lactam antibiotic can be safely used in penicillin allergic patients?

Aztreonam (monobactam)

2. Which group of anticancer agents is extracted from ‘Love Tree’ or ‘Tree of Joy’?

Camptothecins

3. Name the antimicrobial agent whose effects are antagonised by pulmonary surfactants.

Daptomycin

4. A pregnant mother had toxoplasmosis; investigations reveal that fetus in utero is also affected. What is the drug of choice for this condition?

Pyrimethamine + sulfadiazine

5. What’s wrong with a combination of ampicillin + sulbactam for treating beta lactamase producing Serratia?

Serratia produces Class C beta lactamases whereas sulbactam inhibits Class A beta lactamase only.

Round 2

Places & Persons

Rules for Round 2This round has two parts: Part 1 – Places, Part 2 -

Persons

In Part 1, each team will be asked two questions (one in pharmacology and the other in research methodology) and in Part 2, a question.

You have 30 seconds to answer each question.

Ten points for answering correctly. No negative marks for wrong answer.

Unanswered / wrongly answered questions pass to the next team. You get 5 seconds to answer it and five points for answering correctly.

Round 2 – Part I

Places

This drug is the first member of a group of antibiotics, isolated from a soil actinomycetes found near a city in Nebraska, USA and was named after the city.

Identify this drug.

Team B

Lincomycin, the first lincosamide was named after the city Lincoln.

Answer

This method is a group facilitation technique which is an iterative multistage process, designed to transform opinion into group consensus. It goes by the name of a city famous in Greek mythology.

Identify this method / technique.

Team B

Delphi method / technique

Answer

The research work of two scientists (Rachel Fuller Brown and Elizabeth Hazen) at the New York State Health Laboratory led to the discovery of a drug that was named after the lab.

Identify this drug.

Rachel F Brown

Team C

Nystatin

The first three letters ‘Nys’ stand for New York State.

Answer

This is a consensus document that aims to guide the implementation of global clinical trial registration. This is named after the city where the first meeting of this group was held in 2004.

Identify this landmark document.

Team C

Ottawa statement

Answer

This drug was isolated from Streptomyces pimprina (named after the town Pimpri) and developed by the first public sector drug manufacturing company (located at Pimpri) setup by Government of India.

Identify this drug.

Team D

Hamycin named after Hindustan Antibiotics, Pimpri.

Answer

This term refers to the tendency of some people to perform better when they are participants in an experiment.

This effect is named after an electric factory which is named after a town in Illinois, USA. Name this effect.

Team D

Hawthorne Effect (Hawthorne is a small town in Illinois, USA)

A study was conducted at the Hawthorne Works plant of Western Electric Co., to determine if varying the amount of light, workers received changed the worker productivity. It was found that productivity increased due to attention from the research team and not because of changes to the experimental variable.

Answer

This drug has two entirely different actions when administered by two different routes. The drug gets its alternative name from a town near London.

Identify this place.

Team A

Epsom

Magnesium sulphate also known as epsom after the town ‘Epsom’ near London.

Magnesium sulphate by oral route acts as a purgative and by intravenous route is used in eclampsia.

Answer

This statement on research integrity was developed during 2nd World Conference on Research Integrity as a global guide to the conduct of research.

Name this statement which was named after the city which hosted the conference.

Team A

Singapore Statement on Research Integrity

Answer

Round 2 – Part II

Persons

Identify this Indian pharmacologist who worked at Oxford and is credited with the nomenclature of a group of drugs.

Team A

Bramah N. Singh

He worked with Vaughan Williams and formed the classification of antiarrhythmic drugs (Vaughan Williams & Singh classification).

Answer

Identify this person who discovered a drug during his second year as a medical student at Johns Hopkins University.

Photo as a medical student

Photo during later part of life

Team D

Jay McLean

Discovered heparin.

Answer

Identify this famous film personality who is on antiparkinsonian drugs.

Team C

Michael J Fox

Answer

This graduate from Harvard Medical School published the novel ‘The Andromeda Strain’ which anchored his place as a techno thriller. He has written many medical fictions, some of them are A Case of Need, The Terminal Man, Next and Drug of Choice’. He died of lymphoma in November 2008.

Identify him.

Team B

Michael Crichton

Answer