NSF-ERC for Revolutionizing Metallic Biomaterials

Press Release 08-174

NSF Launches Third Generation of Engineering Research Centers with Awards Totaling $92.5 Million

Five new centers will pursue innovations in biorenewable chemicals, green energy systems, communications networks, medical implants and smart lighting.

Jagnnathan "Jag" Sankar, Distinguished Professor of Mechanical Engineering at North Carolina A&T State University, will lead NSF ERC research to create "smart" implants for craniofacial, dental, orthopedic and cardiovascular interventions.

http://www.nsf.gov/news/news_images.jsp?cntn_id=112313&org=NSF

NC A&T State University Made History

 

NOW…..THE REST OF MY STORY KNOWN FACTS……..MUST BECOME REALITY:

Partnership (small or big) must transcends all boundaries

True Partnership takes place at the intellectual level (Performance level and Wavelength) – PASSION DRIVES THEM

Sacrifices at all levels…….Leaders in the trust sense Nothing comes EASY.… it has to Be Earned

Intangibles and Luck will help - for those in the High level performance and partnership zone

NSF-ERC for Revolutionizing Metallic Biomaterials

Center for Advanced Materials and Smart Structures (CAMSS) - Foundation for the ERC

NSF-CREST1997-2008

NSF-NSEC(2004 -

NSF-NIRT(2005- 10)

DoD-CNN(2003 – 2011)

Other NSF, AFRL, ONR, NASA-NIA

Others

Four (4) National Broad-based Advanced, Nano Centers

•Leveraging and Strategic Resources Sharing

•Maximum output for each $ spent•Innovative thinking that cuts across areas

RECENT competitive Programs WON:NSF-US/Europe

Collaboration, NSF-MRIs, Various NSF-SBIRs,STTR,

NSF- NUE (2), DoD-Nanolithography, DoD-DURIP

High Profile Broad Based Materials Activities over 20 years

NSF-ERC for Revolutionizing Metallic Biomaterials

NCAT Facilities: A Foundation for Partnership and Innovation Ecosystem

• Pulsed Laser Deposition Facility• Fuel Cell Processing Laboratory• Coatings Synthesis Laboratory• Bio/Polymer Laboratory• Composite Processing Laboratory• Materials Processing and Sample Preparation Laboratory• Microscopy and Surface Analysis Facility• Electron Microscopy Laboratory• Computation and Visualization Lab• Nanoindentation Facility• Mechanical Testing /High-Temperature Testing Facility• Structural Health Monitoring Research Laboratory• X-ray Diffraction Facility• Physical Property Measurement Lab• Catalysis Facility• Electronic Materials Laboratory • Magnetron Deposition Facility • Direct Write Nano-Fludics Analysis Facility• Micro-Raman facility• Clean Room with Ink Jet, High Speed Camera and

Nanolithography• Bioengineering ERC General facility• FSEM, AFM, Nano CT

Interconnected Labs

Facility,Research,

knowledge without

boundaries

REST OF MY STORY

CENTER Ethics lay a strong foundation for its growth and true partnership

- it is adaptable to innovative technologies

and education

Partnership is Ready to Contribute

with Customer Focus

OTHER ingredient for true partnership:

“Quality (track record)”

“Strong on deadlines and deliverables”ERC Faculty ACROSS

PARTNER INSITUTIONS – T Function

National Science Foundation – Gen 3

“THIS GREW OUT OF OUR RELATIONSHIP AND TRACK STRENGTH”

Engineering Research Centerfor

“Revolutionizing Metallic Biomaterials”

Deputy Director (Pitt)

Deputy Director (UC)

Education & Outreach Director (NCAT)

Global Site

Coordinator (MHH)

Executive Director

(Pitt)

Mark SchulzBill Wagner Devdas Pai Frank Witte Harvey Borovetz

Malformations

National Priority to become the Global Leader

Complex fractures of the Tibia and Femur: Need for Resorbable Fixation

Plates, Pins and Screws

TRAUMA Medical spending: Close to $250 billionTotal knee replacement surgeries increased by 85% in the recent years.

% mini plate surgeries led to infection 64% of Ti plate fixations need to be removed due to complications, infections, painstents are difficult to remove and additional stents must be inserted (elicit an immune response that can lead to the growth of scar tissue and the formation of blood clots)

Value of regenerative implants, Degradable metal anchors, screws, plates, stents and drug eluting

stents, staples, sutures, sternal wires, and meshesPRICELESS

Cleft Lip

will create biodegradable metals with the promise that new kinds of implants can adapt to the human body and eventually dissolve when no longer needed, eliminating multiple surgery and reduce health care costs

“Imagine Implants with their own intelligence that adapt to biological changes of the patient and are automatically eliminated from the body after healing”

Before After

ACL Screw Development Strategic Plan“Partnership both Inside and from Outside”

Alloy Design & Development

Xu (NCAT)Kumta (Pitt)Shanov(UC)

Biomechanics & In-vitro

FunctionalityWoo & Kim (Pitt)

Toxicology & Functional

BiocompatibilityDong (UC)

Barchowsky (Pitt)

Screw Design & Manufacture

Woo, McMahon, Tei & Kim(Pitt)

Schulz & Yin (UC)Kumta (Pitt)Xu (NCAT)

Surface TreatmentYun & Yarmolenko (NCAT)

Vanooij (Ecosil LLC) Shanov (UC)

Material Characterization

Schulz & Yin (UC)Xu (NCAT)

Controlled Drug Release

Wagner (Pitt)

Alloy Corrosion & Degradation

Yun (NCAT)Dong (UC)

IndustryJ&J Depuy Mitek

Alonzo CookGary McAlistar

Orthopedic SurgeonsPatrick McMahon

Marc Philippon, Richard Steadman,James Bradley, Frank Witte

Matteo Tei (Resident)

Design Objectives(ERC Team)

Clinical Trials

J&J Depuy Mitek

Industry

In-Vivo Animal Models

Woo & Kim McMahon & Tei

(Pitt)

E & O Partnership Strategic Plan  

ACL Fixation Screw Medical System

• In-vitro ACL reconstruction using bone-patellar tendon-bone (BPTB) graft• Graft fixation using interference screws

– Mg-based screws (Mg & AZ31 alloy ); Titanium screws as control

Commercial Titanium

Screw

Screws

Mg Screw

Minimal degradation 6 wk post-implant

Interference Screw

NCAT Veterinarian and Animal Surgeon – Getting trained at Pitt

Bioreactor Development at NCAT with Pitt Partnership

Alcian Blue Stain Glycosaminoglycans

Ex Vivo Models For Biologic and Mechanical EvaluationConfidential

Toxicology Pixley (UC)

Functional Biocompatibility

Sfeir, Gilbert, Cui (UPitt)

In vivo Models

Witte (MHH) Dong (UC)

Clinical

Trials

Industry

Characterization Schulz (UC)

Yun (NCAT)

ProcessingShanov (UC) Yun (NCAT)Kumta (UPitt)

AlloysXu (NCAT)

Kumta (UPitt)

Strategic Plan for Biosensors

Sensor designHeineman (UC)Kumta (UPitt)

RESIDUE OF TRUE PARTNERSHIPRMB - Materials Database for Medical Devices - MD2

Key world leaders have accepted our requests to be a part of this materials database collection system and now with ASM- International

Workshop at the FDA+ Multiple Global Biometallic Materials Conferences

http://erc.ncat.edu/biodegradablemetals

NCAT- Bioengineering Program BS, MS – ongoing and Ph.D on its way- History in Making

Gatchell, Linsenmeier, CoC, 2/07

Accredited

Total UG Programs

NCAT

FIRST HBCU AMONG THESE 80+ PROGRAMS!

Dr. Borovetz and Pitt- Bioengineering Program – an Integral part of the development activities

Development of an Innovative, Globally Competitive Research, Education and Diverse Engineering Workforce

Development of an Innovative, Globally Competitive Research, Education and Diverse Engineering Workforce

Academic Programs

Academic Programs

Educational Outreach

Educational Outreach

Technical Dissemination

Technical Dissemination

Economic DevelopmentEconomic

Development

Frontier/Transformational

Scientific Research

Frontier/Transformational

Scientific Research

BS, MS and Ph.D in Bioengineering

BS, MS and Ph.D in Bioengineering

InnovationInnovation

EntrepreneurshipEntrepreneurship

Innovate “R” with Partners

Innovate “R” with Partners

SBIR/ STTRSBIR/ STTR

“D” with Local/Partner Companies

“D” with Local/Partner Companies

SeminarsSeminars

ConferencesSymposia

ConferencesSymposia

Distance Learning

Distance Learning

PublicationsPublications

REU/ LS-AMP/OPT-ED

REU/ LS-AMP/OPT-ED

K-14K-14

ConferencesSymposia

ConferencesSymposia

Teaching the Teacher/RET

Teaching the Teacher/RET

Spin-off Companies

Spin-off Companies

ERC Impact via Effective PartnershipFully - Integrated Management

Hitachi

“One Team ....One Dream”

CSAB

Johnson & Johnson

Em2 Machine Inc