NCI Budget Fact Book for Fiscal Year 1973 › about-nci › budget › fact-book › archive ›...

PREFACE

The information set forth in this publication is

compiled and amended annually by the National

Cancer Institute and is intended primarily for use

by members of the Institute staff, the principal ad-

visory groups to the Institute and others involved inthe administration and management of the National

Cancer Program. Questions regarding any of the in-

formation contained herein may be directed to the

Financial Manager, National Cancer Institute, 9000

Rockville Pike, Bethesda, Maryland 20014.

Revised January 1974

National Cancer InstituteFACT BOOK

1974

DHEW Publication No . (NIH) 74-512

INSTITUTE DATA

Directory of Personnel . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . .

v

National Cancer Institute Historical Data : Legislative Highlights . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . ..

1Historical Events . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . .. . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . . . . . . . . . ..

2

Biographical Sketches of NCI Directors . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . . . . . . . .

2

President's Cancer Panel . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . . .

4National Cancer Advisory Board . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . .. . . . . . . . . . . . . .

5National Cancer Institute Executive Committee . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . . . . . .

6Organization Charts:

National Cancer Institute Organization . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . .. . . . . .. . . . . . . .

7National Cancer. Institute . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . .

8Division of Cancer Cause and Prevention. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . .

9Division of Cancer Biology and Diagnosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ..

. . .. . . . . . . . . . . . . .. . . . . . . . . . . . . . . . .. . . . . .. . . . .. . . . . .. . . 10Division of Cancer Treatment . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 11

Division of Cancer Research Resources & Centers . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . -12

Building Location and Square Footage Occupied . . . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . .. . . . 13

Cancer Statistics . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . 14

National Cancer Program Strategy Hierarchy. . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . . . . . . . . . . . .. . . . 18

National Resources for Cancer Research . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . .. . . . . . . . . . . . . . . . . . . . . . .. . .. 20

BUDGET DATA

Budget Administration Process . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . .. . . . . . . . . . . . . . . . . . . . . .

21Distribution of Grant & Contract Dollars . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . .. . . . . .. . . . . . . . . . . . . . . . 22Foreign Grants and Contracts. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . .. . . . 23Annual Appropriations 1938-1974. . . . . . . . . .. . . . . . . . . . . . ... .. . .. . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . ... . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . 24NCI Program Structure . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . .. . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . 25Appropriations by Budget Activity . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . .. . . . . . . . . . . . . . : . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . .. . . . . . . . . . . . . . 261974 Budget by Organization . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . 27

Cancer Control Obligations . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 28

Task Force Obligations .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 29

Reimbursement to NIH Management Fund . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . .. . . . . . . . . . . . . .. . .. . . . . . 30Obligations and Expenditures 1968-1974 . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 31

Distribution of Personnel 1967-1974 . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . : . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . . . .. . . . . . . . . . .. . . . 32

Comparison by Dollars, Positions and Space . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . .

33Comparison of Research Grants/Research & Research Support Contracts . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . .

34Total NCI Dollars by Mechanisms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . 35Research Positions at the NCI . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . 36

CONTRACT DATA

PAGE

Contracts Administration Process. . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . .

38

Contractors Receiving More Than $750,000 .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . 39

Distribution of Contracts. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . .. . . . . . .. .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . 40

GRANT DATA

Grants Administration Process . . . . . . . . . .. . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . .

41Institutions Receiving More than $750,000 . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . .. . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . 42Distribution of NCI Research Grants by Value of Grant Award . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . .

43

NCI Grant Awards 1965-1974 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44

NCI Grant Dollar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . 45Location of Comprehensive and Specialized Centers and Exploratory Projects . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . 46

DIRECTORYOF

PERSONNEL

NATIONAL CANCER INSTITUTENATIONAL INSTITUTES OF HEALTHBETHESDA, MARYLAND 20014Area Code 301/656-4000

EXTENSION

DIRECTOR

BUILDING 31Dr. Frank J . Rauscher, Jr .

11-A-52

65615DEPUTY DIRECTOR

BUILDING 31Dr. Guy R . Newell

11-A-52

63505ASSISTANT DIRECTOR

BUILDING 31Dr. Bayard H. Morrison III

11-A-51

63308ASSISTANT DIRECTOR

BUILDING 31Dr. Richard A . Tjalma

11-A-46

65854CLINICAL DIRECTOR

BUILDING 10Dr. Alfred S . Ketcham

10-N-116

64164ASSOCIATE DIRECTOR FOR PROGRAM PLANNING AND ANALYSIS

BUILDING 31Mr. Louis M. Carrese

11-A-49

66445ASSOCIATE DIRECTOR FOR CANCER COMMUNICATIONS

BUILDING 31Mr. Frank Karel III

11-A-31

61911ASSOCIATE DIRECTOR FOR CANCER CONTROL

BLAIR BUILDINGDr . Diane J . Fink732A 427-7997

ASSOCIATE DIRECTOR FOR INTERNATIONAL AFFAIRS

BUILDING 31Dr . Gregory T . O'Conor

11-A-19

61932ASSOCIATE DIRECTOR FOR ADMINISTRATIVE MANAGEMENT

BUILDING 31Mr. Calvin B . Baldwin, Jr.

11-A-46

65737CHIEF, ADMINISTRATIVE SERVICES BRANCH

BUILDING 31Mr. Thomas L. Kearns

11-A-29

65801CHIEF, FINANCIAL MANAGEMENT BRANCH

BUILDING 31Mr. Earle L. Browning

11-A-18

65803CHIEF, PERSONNEL MANAGEMENT BRANCH

BUILDING 31Mrs . Rosemary H. Williams

3-A-32

61771CHIEF, RESEARCH CONTRACTS BRANCH

BUILDING 31Mr. Carl A . Fretts

10-A-20

63573

DIRECTOR, DIVISION OF CANCER CAUSE AND PREVENTION

BUILDING 31Dr. James A. Peters

11-A-03

66618ADMINISTRATIVE OFFICER

BUILDING 31Mr. John M. Miller

11-A-11

66556

DIRECTOR, DIVISION OF CANCER BIOLOGY AND DIAGNOSIS

BUILDING 31Dr . Nathaniel I . Berlin

3-A-03


BUILDING 31Mr. H. Kenneth Painter

< 3-A-05

63381

DIRECTOR, DIVISION OF CANCER TREATMENT BUILDING 31Dr . C . Gordon Zubrod

3-A-52


BUILDING 31Mr . Charles E . Leasure, Jr .

3-A-50

65964

DIRECTOR, DIVISION OF CANCER RESEARCH RESOURCES AND CENTERS

BUILDING 31Dr . J . Palmer Saunders

10-A-03

65147CHIEF, GRANTS ADMINISTRATION BRANCH

WESTWOOD BUILDINGMr. Leo F. Buscher, Jr .

8-A-18


BUILDING 31Mrs. Edith F. Phillips

10-A-10

65915

v

NATIONAL CANCER INSTITUTE HISTORICAL DATA

March 7, 1928-Senator M.M. Neely introduced S .3554, "To authorize the National Academy ofSciences to investigate the means and methodsfor affording Federal aid in discovering a curefor cancer and for other purposes."

April 12, 1937-Congressman Warren G. Magnusonof Washington introduced H.R . 6100, an iden-tical bill to S . 2067.

July 8, 1937 - A joint hearing of the Senate andHouse committees was conducted before aSubcommittee on Cancer Research, and arevised bill was written .

July 23, 1937 - The National Cancer Institute Actwas passed by Congress.

August 5,1937- The National Cancer Institute Act,Public Law 244, 75th Congress, was signed byPresident Franklin D . Roosevelt, "To providefor, foster, and aid in coordinating researchrelating to cancer; to establish the NationalCancer Institute ; and for other purposes." Anappropriation of $700,000 for each fiscal yearwas authorized.

July 1 . 1944 - The Public Health Service Act,Public Law 410, 78th Congress, provided that"The National Cancer Institute shall be adivision in the National Institutes of Health."The act also revised and consolidated manyrevisions into a single law. The limit of$700,000 annual appropriation was removed .

December 4, 1970 . Senator Ralph Yarborough,Texas, introduced S . 4564, "A bill which wouldestablish a National Cancer Authority for thepurpose of devising and implementing anational program for the conquest of theworld's most dreaded disease - cancer."

January 22, 1971 . In his State of the Union Message,__ President Nixon announced that he would ask

for the appropriation of an additional $100

LEGISLATIVE HIGHLIGHTS

million to launch an intensive effort to controlcancer, and that he would ask later forwhatever additional funds could be effectivelyused.

March through November, 1971 . Hearings on pro-posed legislation relating to cancer researchexpansion were held by both House and Senatesubcommittees .

October 18, 1971 . The President announced that theArmy's Biological Defense Research Center atFort Detrick, Maryland would be converted intoa leading center for cancer research as part ofthe major campaign to conquer cancer.

December 7, 1971 . After three conference sessionsthat began on November 30, the Senate-HouseConference Committee agreed on S . 1828.

December 9, 1971 . The House passed the bill byvoice vote .

December 10, 1971 . The Senate passed the bill 85-0and sent it to the President for signature .

December 23, 1971 - President Nixon signed P.L.92-218, The National Cancer Act of 1971,providing increased authorities and responsibilities for the NCI Director ; initiating aNational Cancer Program ; establishing a three-member President's Cancer Panel and a 23-member National Cancer Advisory Board, thelatter replacing the National Advisory CancerCouncil ; authorizing the establishment of 15new research, training, and demonstration can-cer centers ; establishing cancer controlprograms as necessary for cooperation withState and other health agencies in thediagnosis, prevention, and treatment of cancer;and providing for the collection, analysis, anddissemination of all data useful in thediagnosis, prevention, and treatment of cancer,including the establishment of an internationalcancer research data bank .

August 5, 1937 - President Franklin D. Rooseveltsigned the National Cancer Act.

November 9, 1937 -The National Advisory CancerCouncil held its first meeting.

January 13, 1938- Dr. Carl Voegtlin was appointedthe first Director of the Institute.

October 31, 1940- President Franklin D. Rooseveltdedicated Building 6.

July 1, 1947 - NCI reorganized to provide for ex-panded program; intramural cancer research,cancer research grants, and cancer control ac-tivities.

July 2, 1953- NCI inaugurated a full-scale clinicalresearch program in the new Clinical Center.

April 1955 - The Cancer Chemotherapy NationalService Center was established in the Instituteto coordinate the first national, voluntary,cooperative cancer chemotherapy program.

January 11, 1966 - NCI reorganized to coordinaterelated activities . The areas of three ScientificDirectors were established : Etiology ;Chemotherapy ; and a group of discipline-oriented laboratories and branches referred toas General Laboratories and Clinics.

February 13, 1967- A Cancer Research Center wasestablished in Baltimore USPHS Hospital toconduct an integrated program of laboratoryand clinical research on the therapy and man-agement of cancer patients .

April 27, 1970- At the request of Senator Ralph W.Yarborough, Chairman of the Committee onLabor and Public Welfare, the Senate approvedthe establishment of the National Panel of Con-sultants on the Conquest of Cancer .

Carl Voegtlin, Ph.D .

JANUARY 13, 1938 TO JULY 31, 1943

Dr . Carl Voegtlin, the Institute's first Director,was born in Zofingen, Switzerland, on July 28,1879 . He studied at the University of Basel, Univer-sity of Munich, University of Geneva, and received aPh.D . degree in 1904 from the University ofFreiburg .

2

HISTORICAL EVENTS

BIOGRAPHICAL SKETCHESOF NCI DIRECTORS

November 25, 1970 - The National Panel of Con-sultants submitted to the Senate Committee areport entitled "National Program for theConquest of Cancer."

October 18, 1971 - President Nixon converted theArmy's former biological warfare facilities atFort Detrick, Md., to research on the causes,treatment and prevention of cancer .

December 23, 1971 - President Nixon signed P.L .92-218, The National Cancer Act of 1971 .

June 22, 1972 - The Institute awarded a contractfor the operation and maintenance of theFrederick Cancer Research Center at FortDetrick, Maryland . This constituted the largestresearch contract ever awarded by a researchcomponent of the National Institutes of Health .

June 30, 1972 - A team of five U.S . cancer scien-tists met with Russian scientists in Moscow toexchange information on cancer drugs. Dr . C.Gordon Zubrod, Scientific Director forChemotherapy, NCI, on behalf of the UnitedStates, signed a U.S.-U .S.S.R . agreement forcontinued cooperation on the exchange ofdrugs, visiting scientists, and information.

July 27, 1972 - A Bureau-level organization wasestablished for the National Cancer Institute,giving the Institute and its componentsorganizational status commensurate with theresponsibilities bestowed on it by The NationalCancer Act of 1971 . Under the reorganization,the Institute was composed of the Office of theDirector and four Divisions: the Division ofCancer Biology and Diagnosis; Division of Can-cer Cause and Prevention ; Division of CancerTreatment; and Division of Cancer Grants .

Upon arriving in the United States in 1905, hebecame a chemistry instructor at the University ofWisconsin, and the following year went to JohnsHopkins where he remained until 1913 . Asprofessor of pharmacology and Chief of theDivision of Pharmacy at the Hygienic Laboratory,his cancer research was largely confined to thebiochemical aspects.

During World War II and for several years thereaf-

ter he was lecturer in pharmacology at the Univer-sity of Rochester, which conferred upon him anhonorary degree of Doctor of Science for his con-tributions to war and other research efforts .Dr . Voegtlin became Director of NCI on January

13, 1938, and held this post until his retirementfrom PHS on July 31, 1943. He retained an activeinterest in NCI until his death in -1960 .

AUGUST 1, 1943 TO JUNE 30, 1947

Roscoe Roy Spencer, M.D .Dr. Roscoe Roy Spencer was born in King William

County, Va., July 28, 1888, and received his M .D.degree from Johns Hopkins in 1913 . Beforebecoming NCI's first Assistant Chief, he was notedfor his contribution in the investigations of RockyMountain spotted fever . .Dr. Spencer became Director of NCI on August 1,

1943, and remained in this post until July 1, 1947 .He had assignments with PHS until his retirementi n

1952.

JULY 1, 1947 TO APRIL 6, 1948

Leonard Andrew Scheele, M.D.Dr. Leonard Andrew Scheele was born in Fort

Wayne, Ind ., July 25, 1907. He received an A.B .degree from University of Michigan and his M.D.degree from Wayne University.Upon entering PHS, he served as assistant

quarantine officer, health officer, special cancerfellow at Memorial Hospital in New York City, of-ficer-in-charge of the National Cancer ControlProgram, and Chief of Medical Division of CivilianDefense before becoming Assistant Chief of NCI in1946 .Dr . Scheele served as Director of NCI from July 1,

1947 to April 6, 1948, when he was appointedSurgeon General, PHS. Upon retirement from PHSin 1956, he became the president of Warner-Chilcott Laboratories, Warner-Lambert Phar-maceutical Co.

MAY 15, 1948 TO JUNE 30, 1960

John Roderick Heller, M.D .Dr . John Roderick Heller was born in Fair Play,

S.C ., on February 27, 1905, and received his M.D .degree from Emory University, Atlanta, Ga. He wascommissioned in PHS in 1934, and became Chiefof PHS's Venereal Disease Division beforebecoming Director of NCI on May 15, 1948, a postwhich he held until June 30, 1960. He then joined

the Memorial Sloan-Kettering Cancer Center in NewYork City as President and Chief Executive Officer,remaining in that position until February 1964.Subsequently he served as Vice Chairman of the

Board of Trustees of the Center and was specialconsultant on international, medical and scientificaffairs to the American Cancer Society . On August1, 1965, Dr . Heller returned to NCI as Special Con-sultant on International Activities .

JULY 1, 1960 TO NOVEMBER 9, 1969

Kenneth Milo Endicott, M.D.Dr. Kenneth Milo Endicott was born in Canon

City, Colo., June 6, 1916, and received his M.D .degree from the University of Colorado in 1939.He entered PHS in 1940, and served in the

Division of Pathology and as Scientific Director,Division of Research Grants, NIH, before being ap-pointed Chief of the Cancer Chemotherapy NationalService Center in 1955 . In 1958 he was appointedAssociate Director, NIH, and served in this capacityuntil appointed Director of NCI on July 1, 1960 .On November 10, 1969, he became Director of

the Bureau of Health Professions Education andManpower Training.

NOVEMBER 10, 1969 TO MAY 4, 1972

Carl Gwin Baker, M.D .Dr. Carl Gwin Baker was born in Louisville, Ky.,

November 27, 1920, and received his M.D. degreefrom the University of Louisville in 1944 and hisM.A . degree in biochemistry from the University ofCalifornia at Berkeley in 1949. He served as aMedical Officer in the U .S . Navy, 1945-1946 .He entered the PHS in 1949 and served in the

Laboratory of Biochemistry, the Research GrantsBranch, and the Office of the Director, NCI, until1958 when he was appointed Assistant Director,NCI . During 1957-1958 he was Assistant to theAssociate Director for Intramural Research, NIH.He became Associate Director for Program, NCI, in1961 after serving as Acting Scientific Director forIntramural Research . He was named ScientificDirector for Etiology, NCI, in 1967 . He became Act-ing Director of NCI November 10, 1969, and was_appointed Director of NCI July 13, 1970 .On May 5, 1972 he was named Special Assistant

to the Director, NIH, with responsibility to plan andestablish a new Office of Technology Im-plementation. Following his retirement from thePublic Health Service on September 1, 1972, hebecame President of Hazleton Laboratories, Inc ., ofFalls Church, Va .

Guy Rene Newell, M.D .

MAY 5, 1972 TO PRESENT

Frank Joseph Rauscher, Jr., Ph.D.Dr . Frank Joseph Rauscher, Jr. was born in

Hellertown, Pennsylvania, on May 24, 1931 . Hereceived his B.S . degree from Moravian College in1953 and his Ph.D. degree from Rutgers in 1957.Dr. Rauscher came to the National Cancer In-

stitute in 1959 and served as a microbiologist inthe Laboratory of Viral Oncology until 1964, whenhe was appointed Head, Viral Oncology Section . Heserved in this position until 1965, when he was

AUGUST 1, 1973 TO PRESENT

The new Deputy Director of the National CancerInstitute, Dr. Guy R. Newell, was born in Bogalusa,Louisiana, September 21, 1937 . Dr . Newellreceived both his B.S . (1959) and M.D . (1962)Degrees from Tulane University and his M.S . inHygiene from the Harvard School of Public Healthin 1968. From July 1963 to June 1965 he served asa Research Planning Associate in the Office of the

DIRECTORNATIONAL CANCER PROGRAMNATIONAL CANCER INSTITUTE

DEPUTY DIRECTORNATIONAL CANCER INSTITUTE

Director, NCI . Between July 1965 and June 1968 hereceived training in internal medicine and oncologyat the Johns Hopkins Hospital and the Peter BentBrigham Hospital . He returned to the NCI in July1968, where he was an Assistant for Program, ViralOncology and served as Executive Secretary,Biometry & Epidemiology Contract Review Com-mittee until June 1970. From July 1970 until hisappointment as Deputy Director, NCI in August1973, Dr. Newell held positions of Assistant andthen Associate Professor of Epidemiology at TulaneUniversity.

PRESIDENT'S CANCER PANEL

made Acting Chief, Viral Leukemia and LymphomaBranch . During this period, he also served as Chair-man, Special Virus Cancer Program . In 1966, hebecame Chief of the Viral Leukemia and LymphomaBranch until 1967 when he was appointedAssociate Scientific Director for Viral Oncology. Dr .Rauscher became Acting Scientific Director forEtiology in 1969, and was subsequently namedScientific D_ irector in 1970 .On May 5, 1972, President Nixon named him

Director of the National Cancer Institute and of theNational Cancer Program .

EXPIRATIONOF

APPOINTMENT

Mr . Benno C. Schmidt, Chairman 2-16-75J . H . Whitney & Co.New York City, New York

Dr. R . Lee Clark 2-20-77University of TexasM.D. Anderson Tumor ClinicHouston, Texas

Dr . Ray D . Owen 2-20-76California Technological InstitutePasadena, California

NATIONAL CANCER ADVISORY BOARD

Rockefeller University

Armed Forces Institute of PathologyNew York, New York

Washington, D.C .

APPOINTEESEXPIRATION

OFAPPOINTMENT

EXPIRATIONOF

APPOINTMENT

Dr. Jonathan E . Rhoads, Chairman 3-31-78 Dr . Phillippe Shubik 3-9-76University of Pennsylvania University of NebraskaPhiladelphia, Pennsylvania Omaha, Nebraska

Dr. Harold Amos 3-31-76 Dr . Howard E . Skipper 3-31-78Harvard Medical School Southern Research InstituteBoston, Massachusetts Birmingham, Alabama

Mr . Elmer H . Bobst 3-31-76 Dr . Sol Spiegelman 3-31-74Warner-Lambert Company Columbia UniversityNew York, New York New York, New York

Dr . Arnold L. BrownBrown 9-30-74 Dr. James D. Watson 3-31-74Mayo Clinic Cold Spring Harbor LaboratoryRochester, Minnesota Cold Spring Harbor, New York

Dr . Frank J . Dixon 3-31-78 Dr. W. Clarke Wescoe 3-31-78Scripps Clinic and Research Foundation Sterling Drug, Inc .La Jolla, California New York, New York

Mr . James S . Gilmore, Jr. 9-30-74Gilmore Broadcasting CorporationKalamazoo, Michigan EX-OFFICIO MEMBERS

Dr . John R. Hogness 3-31-78National Academy of SciencesWashington, D.C . Honorable Caspar W. Weinberger

Mr. Donald E. Johnson 3-31-76 Secretary, Department of Health, Education,and Welfare Washington, D.C.Advertisers Press, Inc .

Flint, Michigan Dr. Marc J . MusserMrs . Mary Lasker 3-31-74 Veterans Administration

Washington, D.C .Albert and Mary Lasker FoundationNew York, New York Dr. H . Guyford Stever

Dr. Irving M . London 3-31-76 Director, National Science FoundationHarvard-MIT Program in Health Sciences

Washington, D.C .

and Technology Dr. Robert S . StoneCambridge, Massachusetts Director, National Institutes of Health

Dr . Gerald P. Murphy 3-31-76 Bethesda, MarylandRoswell Park Memorial Institute Dr . Richard S . WilburBuffalo, New York Department of Defense

Dr . Gerald H . Ogura 3-31-74 Washington, D.C.Washington UniversitySt. Louis, Missouri

Mr. Laurance S. Rockefeller 3-31-78 ALTERNATESRockefeller Brothers FoundationNew York, New York

Dr . Harold P . Rusch 3-31-74 Dr . Lyndon E . Lee, Jr.University of Wisconsin Medical Center Veterans AdministrationMadison, Wisconsin Washington, D.C .

Dr . Frederick Seitz 3-31-74 Dr . D. Murray Angevine

NATIONAL CANCER INSTITUTE EXECUTIVE COMMITTEE

Dr . Guy R . Newell, ChairmanDeputy Director, NCI

Mr. Calvin B . Baldwin, Jr.Associate Director for Administrative Management

Dr . Nathaniel I . BerlinDirector, Division of Cancer Biology & Diagnosis

Mr . . Louis M . CarreseAssociate Director for Program Planning and Analysis

Dr. Diane J . FinkAssociate Director for Cancer Control

Mr. Frank Karel IIIAssociate Director for Cancer Communications

Dr . Alfred M. KetchamClinical Director, NCI

Dr . Bayard H . Morrison III,Assistant Director, NCI

Dr. Gregory T . O'ConorAssociate Director for International Affairs

Dr. James A. PetersDirector, Division of Cancer Cause and Prevention

Dr . J . Palmer SaundersDirector, Division of Cancer Research Resources and Centers

Dr. Richard A . TjalmaAssistant Director, NCI

Dr. Charles G . ZubrodDirector, Division of Cancer Treatment

Dr. Frank J . Rauscher, Jr ., Ex OfficioDirector, National Cancer Program, National Cancer Institute

NATIONAL CANCER INSTITUTE ORGANIZATION

DIRECTOR

NCIEXECUTIVECOMMITTEE

ASSOCIATE DIRECTOR ASSOCIATE DIRECTOR ASSOCIATE DIRECTOR ASSOCIATE DIRECTOR ASSOCIATE DIRECTORFOR FOR FOR FOR FORPROGRAM .PLANNING CANCER INTERNATIONAL CANCER ADMINISTRATIVEAND COMMUNICATIONS AFFAIRS CONTROL ° MANAGEMENTANALYSIS

DIRECTOR, DIVISION DIRECTOR, DIVISION DIRECTOR, DIVISION DIRECTOR, DIVISIONOF OF OF OF CANCER

CANCER CAUSE CANCER BIOLOGY CANCER RESEARCH RESOURCESAND AND TREATMENT AND

PREVENTION DIAGNOSIS CENTERS

DEPUTY DIRECTOR NATIONALPRESIDENT'SASSISTANT DIRECTORS CANCERCANCERCLINICAL DIRECTOR ADVISORYPANEL BOARD

8

MaNatan

stitute; evaluates resource needsfor the National Cancer Program ;develops and provides supportfor management and scientificinformation systems .

PROGRAM ANALYSIS ANDFORMULATION BRANCH

Dr. Abraham Cantarow (acting)

SYSTEMS PLANNINGBRANCH

Mr. John E Shulskis

MANAGEMENT &SCIENCEINFORMATION SYSTEMS

vacant

Plans, develops, directs, and coordinates the activities and programs of the Institute andof the National Cancer Program; and provides overall administrative guidance and services.

terprets program and organizes,prepares and disseminatesreports on cancer research forresearch institutions and otherorganizations participating in theNCP; maintains liaison with NCIconstituents on behalf of theDirector; responds to publicinquiries; prepares and coor-dinates internal reports fordissemination within the In-stitute, the Executive Branch,and the Congress ; and serves asa focal point for information onlegislation .

NATIONAL CANCER INSTITUTEDr. Frank 1. Rauscher, Jr ., DirectorDr. Guy R. Newell, Deputy Director

Develops a national program planfor Cancer Control in coor-dination with the Divisions of theNCI ; administers and managesthe cancer control program; andmaintains liaison with othergovernmental agencies and withprofessional and voluntaryorganizations which have cancercontrol-related activities or an in-terest in cancer control.

ASSOCIATE DIRECTORFOR

CANCER CONTROLDr . Diane J . Fink


INTERNATIONAL AFFAIRSDr . Gregory T, O'Conor

Plans, coordinates, and managescooperative international cancerresearch activities and providesleadership within the NationalCancer Institute for the develop-ment of international programsand activities.


ADMINISTRATIVE MANAGEMENTMr. Calvin B. Baldwin, Jr .

Directs, coordinates, and con-ducts administrative manage-ment activities of the Institute in-cluding: personnel, budget, con-tracts, and administrative ser-vices ; advises Director on ad-ministrative managementaspects of the program.

ASSOCIATE DIRECTORFOR PROGRAM

PLANNING AND ANALYSISMr. Louis M. Carrese


CANCER COMMUNICATIONSMr. Frank Karel III

nages development of the Develops and manages theional Cancer Program Plan ; program communications ac-lyzes programs of the In- tivities of the NCI/NCP ; in-

PROGRAM LIAISON PROGRAM MANAGEMENT CAUSE & PREVENTION ADMINISTRATIVE PERSONNEL MANAGEMENTBRANCH BRANCH BRANCH

ii

SERVICES BRANCH BRANCHMr. Robert G. Schonfeld Dr . George E. Jay, Jr. Dr. Robert L Woolridge Mr. Thomas L Kearns Mrs . Rosemary H . Williams

EDUCATION &TECHNICAL DETECTION & FINANCIAL MANAGEMENT RESEARCH CONTRACTSREPORTS BRANCH DIAGNOSIS BRANCH TREATMENT BRANCH BRANCH BRANCHMr . William S. Gray vacant

vacantMr. Earle L Browning Mr . Carl A . Fretts

REHABILITATION BRANCH EDUCATION &TRAINING BRANCH

Mr. Lawrence D . BurkeDr. Margaret H . Edwards

CANCER CAUSEAND PREVENTION

ADVISORY COMMITTEE

DIVISION OF CANCER CAUSE AND PREVENTIONDr. James A. Peters, Director

Dr . Gio B. God, Deputy Director (acting)

Plans and directs a program of laboratory, field and demographicresearch on the cause and natural history of cancer and meansfor preventing cancer through direct in-house research andthrough research contracts; evaluates mechanisms of cancer in-duction by viruses and by environmental carcinogenic hazards;serves as the focal point for the Federal Government on the syn-thesis of clinical, epidemiological, and experimental datarelating to the cause of cancer.

ASSOCIATE ÍDIRECTOR FORPROGRAM

Plans, implements, and administers a coordinated programof basic and applied research on carcinogenesis bychemical and physical factors and on its prevention; con-ducts programs in the areas of: (a) coordination on en-vironmental carcinogenesis; (b) epidemiologic pathology;and (c) registry of experimental tumors.

BIOLOGY BRANCHDr. Herbert 1. Rapp

SCIENTIFIC COORDINATORFREDERICK CANCER RESEARCH

CENTERDr. William W. Payne

VIRAL LEUKEMIA ANDLYMPHOMA BRANCHDr. George 1. Todaro

Analyzes cause and prevention research activitiesof the Institute and participates in the planning ofa coordinated cause and prevention researchprogram ; plans, analyzes, and coordinates theprogram of the Division; and provides leadershipfor and coordinates Division scientific andtechnical information activities.

ASSOCIATE DIRECTORFOR CLINICAL RESEARCH

Dr. Alfred S. Ketcham

Plans and directs the clinicalprograms of the Division .

Dr . Marvin A. Lutzner

SURGERYBRANCH

Dr.

DERMATOLOGYBRANCH

Alfred S. Ketcham

METABOLISMBRANCH

Dr. Thomas A . Waldmann

LABORATORY OFPATHOLOGY

Dr. Louis B. Thomas

RBRANCH

Dr . Ralph E:Johnson

DIVISION OF CANCER BIOLOGY AND DIAGNOSISDr . Nathaniel 1 . Berlin, Director

Plans and directs the Institute's general laboratoryand clinical research activities ; plans and managescollaborative programs in immunology, diagnosisand breast cancer ; and serves as the national focalpoint for programs to improve the detection anddiagnosis of human cancers .

LABORATORY OFPHYSIOLOGY

Dr. Nathaniel I. Berlin(acting)

LABORATORY OFPATHOPHYSIOLOGYDr. P. M.

Gullino(acting)

ASSOCIATE DIRECTORFOR IMMUNOLOGYDr. William D. Terry

(acting)

Plans, directs and evaluates a programof both intramural and contactresearch in tumor immunology.

LABORATORY OF- . CELL BIOLOGYDr. Lloyd W. Law

LABORATORY OFBIOCHEMISTRY

LABORATORY OFMOLECULAR BIOLOGY

Dr . Ira H. Pastan

BOARD OFSCIENTIFICCOUNSELORS

ASSOCIATE DIRECTORFOR PROGRAM PLANNING

Dr. Irvin C . Plough

Analyzes research programs of theDivision and participates in researchplanning and evaluation, and in theestablishment of priorities in terms ofpublic need and probability of success ;maintains management informationfiles on all research projects ; andmonitors the professional aspects ofresearch contract management.

PLANNING ANDANALYSIS BRANCH

Dr. Ihor 1. Masnyk

DIAGNOSISBRANCH

Dr. William Pomerance

BREAST CANCERPROGRAM

COORDINATINGBRANCH

Dr. Erwin P. Vollmer

ASSOCIATE DIRECTORFOR CANCER THERAPY

EVALUATION

Dr. Stephen K. Carter

Plans and directs the clinical con-tract program, testing combinedmodality therapy approaches andthe clinical testing of in-vestigational new agents; anddirects the evaluation of the ef-fectiveness of specific types andmethods of cancer therapy.

CANCER TREATMENTADVISORY COMMITTEE

ASSOCIATE DIRECTORFOR MEDICAL ONCOLOGY

Dr. Paul P. Carbone

Plans and directs the clinicalresearch aspects of the programs ofthe Division .

DIVISION OF CANCER TREATMENTDr. C . Gordon Zubrod, Director

Dr . Seymour M. Perry, Deputy Director

Plans, directs and coordinates an integratedprogram of cancer treatment activities withthe objective of curing or controlling cancerin man by utilizing combination modalitiesincluding chemical, surgical, radiologicaland certain immunological techniques ; ad-ministers a total drug development program;and serves as the national focal point for in-formation and data on cancer treatmentstudies.


EXPERIMENTAL THERAPEUTICSDr. Vincent T. Oliverio

Plans and directs studies con-cerning the pharmacologic andtoxicologic aspects of cancerchemotherapy including studies onthe growth characteristics of nor-mal and malignant cells and the ef-fects of chemotherapeutic agentson these cells .

J 4

ASSOCIATE DIRECTORFOR DRUG RESEARCH &

DEVELOPMENT

DRUG DEVELOPMENTBRANCH

Dr. Harry B. Wood,Jr.

DRUG EVALUATIONBRANCH

Dr. John M. Venditti

LABORATORY OFEXPERIMENTALCHEMOTHERAPY

ASSOCIATE DIRECTORFOR PROGRAM

Dr. Seymour M. Perry

Analyzes treatment activities of the Institute ;participates in planning of treatment program;and evaluates areas of cancer treatment withgreatest need for study.

ASSOCIATE DIRECTORFOR BALTIMORE CANCER

RESEARCH CENTER

LABORATORYOF PHARMACOLOGYDr. Carl Levy (acting)

CLINICAL BRANCH

Dr. Michael D. Walker

LABORATORY OF CHEMICALPHARMACOLOGY

Dr . Richard A. Adamson (acting)

LABORATORY OF TOXICOLOGYDr. Anthony M. Guarino

(acting)

LABORATORY OF MOLECULARPHARMACOLOGYDr. Kurt W. Kohn

LABORATORY OF TUMOR CELLr BIOLOGYDr. Robert C. Gallo

INVESTIGATIONAL MEDICINE BRANCHDRUG BRANCH Dr. Vincent T. DevitaDr. Milan Slavik (acting)

COMBINED MODALITY PEDIATRIC ONCOLOGYBRANCH

i

BRANCHDr. Stephen K. Carter (acting) Dr. John L Ziegler

NCI-VA MEDICALONCOLOGY BRANCHDr. Oleg S. Selawry

Dr . Saul A. Schepartz

Plans and directs the first, or drugdevelopment and evaluation phase,of the cancer chemotherapyprogram, primarily conducted

Dr. Michael D. Walker

Conducts an integrated program oflaboratory and clinical research onthe therapy and management ofcancer patients, including phar-

through research contracts and in- macologic investigations of thecluding technical information ser- mechanisms of action of anti-vices to DR&D and other cancer drugs.collaborative programs .

Plans and directs NCI grant-supported activities, and recom-mends Institute policies relating tothe administration of biomedicaland clinical research grantprograms ; develops, reviews andcoordinates plans and criteria forthe implementation of NCI grant-supported research programs andevaluates effectiveness of these ac-tivities in achieving the Institute'smissions ; and advises the Directorof the Division, the National Can-cer Advisory Board, and other ad-visory bodies of grant activitiesand developments.

DIVISION OF CANCER RESEARCH RESOURCES AND CENTERSDr. J. Palmer Saunders, Director

Dr . William A. Walter, Deputy Director

Plans and directs the Institute's grant-supported activities ; recommends Institutepolicies relating to the administration of grant programs ; develops, reviews and coor-dinates plans and criteria for the implementation of NCI grants and evaluates ef-fectiveness of grant-supported activities in achieving the Institute's missions ; andadvises the Institute Director, the National Cancer Advisory Board, and other ad-visory bodies of grant activities and developments.

Plans and directs the Cancer Cen-ters Program, the ResearchFacilities Construction Program,and the Cancer Clinical EducationProgram ; supplies data to reviewcommittees and the National Can-'cer Advisory Board ; evaluates theneed for and effectiveness of theseprograms ; interprets programs togrant applicants, grantees, univer-sities and research institutions ;and advises the Director of theDivision, the National Cancer Ad-visory Board and other advisorybodies of grants activities anddevelopments .

Serves as the Division focus forprogram planning and evaluationactivities including development ofprogram objectives, alternatives,and policy positions ; stimulates andguides divisional planning ac-tivities, addresses program ac-complishments, and overseesanalytical and reporting functions ;applies management sciencetechniques including systemsanalysis and design, operationsresearch, and other analytical ap-proaches to Division programs ; andmaintains liaison with the Office ofProgram Planning, Office of theDirector, NCI .

GRANTS ADMINISTRATIONBRANCH

Mr. Leo F. Buscher, N .

BIOMEDICAL RESEARCH CANCER CENTERS BRANCHPROGRAMS BRANCH Dr. John W. Yarbro PROGRAM ANALYSIS AND

Dr. Thaddeus J. Domanski (acting) . EVALUATION BRANCHMr . Harry Y. Canter

CLINICAL INVESTIGATIONS RESEARCH FACILITIESBRANCH CONSTRUCTION BRANCH PROGRAM DEVELOPMENT AND

Dr . William G . Hammond Dr . Donald G . Fox OPERATIONS BRANCHDr. John T. Kalberer, 1r. (acting)

NATIONAL ORGAN SITE CANCER CLINICALPROGRAMS BRANCH

y

EDUCATION BRANCHDr. Samuel Price Dr. William L Ross (acting)

1ASSOCIATE DIRECTOR ASSOCIATE DIRECTOR ASSOCIATE DIRECTOR REVIEW AND

FOR RESEARCH PROGRAMS FOR CANCER CENTERS FOR PROGRAM PLANNING REFERRAL BRANCHDr. Thomas 1. King (acting) Dr. John W . Yarbro (acting) Dr. John T. Kalberer, Jr. (acting) Dr . Mordecai H. Gordon

270

EYE RESEARCHFOUNDATION

2,141 Square Feet6 Personnel

BUILDING 10CLINICAL CENTER84,190 Square Feet

394 Personnel

BUILDING 37117,687 Square Feet

542 Personnel

BUILDING LOCATION ANDSQUARE FOOTAGE OCCUPIEDBY FULL-TIME PERMANENTPERSONNEL IN BETHESDA,MARYLAND AREAAS OF JUNE 30, 1973

TOTALApproximatety 426,661 Square Feet

1,736 Personnel*

WESTWOOD BUILDING25,890 Square Feet

152 Personnel

Route 70S

Route 495 (Capital Beltway)

Cedar Lane

Old Georgetown Road


2 Personnel


4 Personnel

Bradley

LITTON BIONETICS BUILDING1,180 Square Feet

18 Personnel

ASZ

OZ

Nicholson Lane


210 Personnel


38 Personnel


94 Personnel

LANDOW BUILDING37,843 Square Feet

195 Personnel

13

CANCER STATISTICS

Cancer Incidence

More than 53 million Americans now living willeventually have cancer - according to presentrates - about one in four persons. Over the years,cancer will strike in 2 out of 3 American families .In 1974, there will be an estimated 655,000 newcancer cases diagnosed. (This does not includesuperficial skin cancer or carcinoma-in-situ of theuterine cervix, which have been included in prioryear statistics.)

Changes in the Incidence of Cancer'

The trend in cancer incidence based on the 1937,1947, and 1969 surveys is depicted in the figuresthat follow . For the white population, comparison ismade with trend data from the state of Connecticut,which has been collecting continuous data on theincidence of cancer since 19352. For both the whiteand black populations, the trend in cancer in-cidence is compared with the trend in cancer mor-tality as reported by the National Center for HealthStatistics .There is a marked difference in trend for males

and females. Among males, incidence of and mor-tality from cancer has been increasingly con-tinuously. The increase has been particularly largeamong blacks . In part, the reported increase amongblack men may reflect improvement in the deliveryof medical care resulting in more completediagnosis of the disease. However, it is likely that asubstantial fraction of the reported increasereflects the impact of environmental factors, e.g.,movement from rural to urban areas and con-centration in inner cities, changes in occupation,

'Source: "Report on the Third National Cancer Survey", Seventh NationalCancer Conference Proceedings.2Cancer in Connecticut, 1935-62 Connecticut State Department of Health ;Hartford, Connecticut, 1966 . More recent data have been provided by Dr.Barbara Christine, Director, Connecticut Tumor Registry.

1 4

and changes in eating, drinking, and smoking prac-tices.For females of both races, the available data in-

dicate that the incidence of cancer is eitherdecreasing (survey data) or leveling off (Con-necticut data). Among white women, mortality fromcancer has been decreasing; among black womenthe mortality rate has remained at the same levelsince 1950 .

Third National Cancer Survey

The National Cancer Institute is in the final processof completing the Third National Cancer Survey, aproject designed to provide incidence andprevalence data for the three-year period 1969-1971 for seven metropolitan areas and two states .Cancer is not a reportable disease in most of theUnited States and it has been over twenty yearssince a previous incidence study was undertaken .Two earlier studies on cancer incidence, in 1937and 1947-48 covered ten large metropolitan areas.A survey in Iowa in 1950 helped provide knowledgeof cancer incidence in rural areas. The field work ofthe current study is completed and the analysis isin process.

Information was gathered from all hospitals,clinics, laboratories, vital statistics offices andphysicians in each survey area concerning patientswith active cancer during the years 1969, 1970 and1971 . A preliminary report on cancer incidencerates for 1969 was issued in 1971 and the reportfor all three years will be published during 1974.Data will be given by sites and histologic types ofcancer by sex, race, age and geographic areas.Supplementary information has been collected

on a ten percent sample of patients, regarding ex-tent of disease, treatment, cost of medical care andeconomic impact on the family . As the analysisproceeds, reports will be issued .

2O

000óo .

400

300

200

WP 400WFQ6

300

200

100

WHITEMALES

ALL SITESa-~ U.S . INCIDENCE

--c CONNECTICUT INCIDENCEo----o U.S. MORTALITYo----o CONNECTICUT MORTALITY

OTIQ

a

ALL SITES

*All sites : trend of cancer incidence and mortality rates, 1935-1969 (age-adjusted, 1950 standard population). Note : In order tomake the current figures comparable with the earlier data, leukemia, Hodgkin's disease, skin cancer and carcinoma in situ of theuterine cervix were excluded.

MORTALITY FOR THE FIVE LEADING CANCERSITES BY AGE GROUP AND SEX - 1970

*Includes Brain and Central Nervous System

Source : National Center for Health Statistics, 1970**Includes Lymphosarcoma and other Lymphomas

1 5

TOTAL UNDER15 15 - 34 35 - 54 55 - 74 75 & OVER

MALE FEMALE MALE FEMALE MALE FEMALE MALE FEMALE MALE FEMALE MALE FEMALE

Lung Breast Leukemia Leukemia Leukemia Breast Lung Breast Lung Breast ProstateColon &Rectum

52,801 29,652 933 739 692 517 9,361 8,750 34,121 14,167 9,510 9,610

Colon & Colon & Brain* Brain* Hodgkin's Leukemia Colon & Lung Colon & Colon & Lung Breast_Rectum Rectum Disease Rectum Rectum Rectum

22,142 23,838 509 371 488 507 2,421 3,246 11,650 1,523 9,110 6,213

Prostate Lung Lympho-** Bone Brain* Uterus Pancreas Uterus Prostate Lung Colon & Stomachsarcoma Rectum

17,252 12,367 138 91 386 346 1,416 3,120 7,423 6,617 7,576 2,744

Pancreas Uterus Bone Kidney TestisHodgkin's rain* Colon & Pancreas Uterus Stomach PancreasDisease Rectum

10,063 12,060 79 65 411 321 1,334 2,559 5,594 5,903 3,234 2,925

Stomach Ovary Kidney Lympho-** Lympho-** Brain* Stomach Ovary Stomach Ovary Pancreas Uterussarcoma sarcoma

9,805 9,958 71 55 247 286 1,221 2,538 5,288 5,398 2,709 2,687

400U.S. INCIDENCE

- - U.S. MORTALITY

WHITE FEMALES --a CONNECTICUT INCIDENCEr---o CONNECTICUT MORTALITY300

200

100

RELATIONSHIP OF CANCER TO LEADING CAUSESOF DEATH IN THE UNITED STATES

1970

Source: National Center for Health Statistics, 1970Cause of death classified by the Eighth Revision, International Classification of Diseases, Adapted, 1965

RANK CAUSE OF DEATHNUMBER

OFDEATHS

DEATH RATEPER

100,000POPULATION

PERCENTOF

TOTALDEATHS

All Causes 1,921,031 945.3 100.0

1 Diseases of heart 735,542 362.0 . 38.3

2 Cancer 330,730 162.8 17.2

3 Cerebrovascular diseases 207,166 101 .9 10.8

4 Accidents 114,638 56.4 5.9

Motor vehicle accidents (54,633) (26.9) (2 .8)

All other accidents (60,005) (29.5) (3.1)

5 Influenza and pneumonia 62,739 30.9 3.3

6 Certain causes of mortality in early infancy 43,205 21 .3 2.2

7 Diabetes mellitus 38,324 18.9 2.0

8 Arteriosclerosis 31,682 15.6 1 .6

9 Cirrhosis of liver 31,399 15.5 1.6

10 Bronchitis, emphysema, and asthma 30,889 15.2 1.6

11 Suicide 23,480 11 .6 1 .2

12 Homicide 16,848 8.3 0.9

13 Congenital anomalies 16,824 8.3 0.9

14 Nephritis and nephrosis' 8,877 4.4 0.5

15 Peptic ulcer 8,607 4.2 0.5

All other cases 220,081 108.0 11 .5

ESTIMATED CANCER DEATHS AND NEW CASES BY SEX AND SITE -- 1974

Note: The estimates of new cancer cases are offered as a rough guide and should not be regarded as definitive. Especially note that year to yearchanges may only represent improvements in the basic data .

*Carcinoma-in-situ of the uterine cervix and superficial skin cancers not included in totals.(Reprinted with permission from Cancer Facts and Figures, American Cancer Society, 1974, from data supplied by the National Cancer Institute.)

1 7

ESTIMATED DEATHSTOTAL MALE FEMALE355,000 193,000 162,000

7,900 5,700 2,200225 200 25

1,800 1,300 500650 400 250'l525 400 450125

1,250 8003,450 2,600 850

100,100 53,100 47,0006,300 4,600 1,700

14,300 8,400 5,900650 300 _350

37,300 17,300 20,00010J00 6,090 4,7009,800 4,800 5,00019,400 10,900 8,5001,650 800 850

79,900 63,500 16,4003,200 2,800 400

75,400 59,900 15,5001,300 _8-00 500

8,700 5,000 3,7001,900 1,100 8001,700 900, 8005,100 1,000 _ ?1100

32,750 250 32,500

41,800 19,000 22,8007,800 - 7,800¡3,400 _ 3,40010,700 -

_10,700

900 - 90018,000 18,000 -1,000 1,000 -

16,200 10,700 5,5009,200 6,300 2,9007,000 4,400 2,600

350 150 200

8,100 4,700 3,400

1,650 650 1,0001,150 350 800500 300 200

15,300 8,600 6,700

220,400 11,290 9,2007,700 4,100 3,6003,700 2,200 1,5004,600 2,400 2,2004,400 2,500 1,900

21,850 10,450 11,400

SITEAll Sites*Buccal Cavity & Pharynx (Oral)LipTongueSalivary GlandFloor of MouthOther & Unspecified MouthPharynx

Digestive OrgansEsophagusStomachSmall IntestineLarge Intestine (Colon-Rectum)

LiverPancreasOther & Unspecified Digestive

Respiratory SystemLarynxLungOther & Unspecified Respiratory

Bone, Tissue and SkinBoneConnective TissueSkin (Melanoma)*

Breast

Genital OrgansCervix, Invasive* UterusCorpus UteriOvaryOther Female GenitalProstateOther Male Genital

Urinary OrgansBladderKidney & Other Urinary

Eye

Brain & Central Nervous System

Endocrine GlandsThyroidOther Endocrine

Leukemia

LymphomasLymphosarcoma & ReticulosarcomaHodgkin's DiseaseMultiple MyelomaOther Lymphomas,

All Other & Unspecified Sites

_ESTIMATED NEW CASESTOTAL MALE FEMALE

655,000 326,000 329,00023,700 16,700' 7,000

,700 3,300 4004,800 3,400 1,400

8,500 5,100 3,400

6,700 4,900 1,800

166,900 86,800 80,1007,400 5,500 1,900

23,100 14,000 9,1002,200 1,200 1,00068,000

_31,000 : : 37,000

31,000 17,000! 14,00011,400 5,600 ; 5,80020,300 11,000 9,3003,500 1,500_ 2,000

95,200 77,000 18,2009,500 8,300' 1,200,

j 83,000_67,000' 16,000

2,700 1,700- 1,000

14,700 7,800 7,4002',000 1,100 9004500206r

2,400_3,800

2,10'O' 4,400

89,700 700! 89,000;

125 800 58,100 67,70019,000' - 19,00027,000' - 27,00017,000 - 17,0004,700 - 4,700

54,000 54,000 -4,100 4,100 -42'28:400

900 30,00021,000

12,9007,400

14,500 9,000 5,500

1,700 800 900

10,700 5,900 4,800

8,900 2,600 6,3007,800 2,100 5,7001,100 500 600

21,200 12,000 9,200

27,600 15,100 12,5009,900 5,400 4,5006,900 4,100 2,8007,500 3,800 3,700

3,300 1,800 1,500

26,000 13,000 13,000

NATIONAL CANCER PROGRAM STRATEGY HIERARCHY

THE NATIONALCANCER PROGRAM (NCP) STRATEGY IS THE COM-BINATION OF SELECTED LABORATORY, FIELD AND CLINICALRESEARCH AND CONTROL COURSES OF ACTION NECESSARY TOACHIEVE THE PROGRAM OBJECTIVES AND GOAL.

o TO FACILITATE PLANNING AND IMPLEMENTATION OF THE PRO-GRAM STRATEGY, IT HAS BEEN ORGANIZED IN A HIERARCHICALFORMAT WITH THE FOLLOWING LEVELS :

- NATIONAL CANCER PROGRAM GOAL- RESEARCH THRUSTS AND CONTROL INTERVENTIONS- RESEARCH AND CONTROL OBJECTIVES- RESEARCH AND CONTROL APPROACHES- RESEARCH AND CONTROL APPROACH ELEMENTS- RESEARCH AND CONTROL PROJECT AREAS

THE HIERARCHICAL STRUCTURE PROVIDES CONTINUING FOCUSON CONSTANT, DISEASE-ORIENTED OBJECTIVES.

THE FIRST THREE LEVELS OF THE HIERARCHY ARE PRESENTEDON THE FIGURE .

- THE TOP LEVEL (CENTER OF THE CIRCLE) IS THE NATIONALPROGRAM GOAL.

- THE SECOND LEVEL INCLUDES THE NCP RESEARCH THRUSTSAND CONTROL INTERVENTIONS .

- THE THIRD LEVEL INCLUDES THE NCP RESEARCH AND CON-TROL OBJECTIVES.

- THE NEXT THREE LEVELS-APPROACHES, APPROACH ELEMENTSAND PROJECT AREAS-PROVIDE INCREASINGLY MORE DETAIL-ED DEFINITION OF THE SCIENCE AND ACTIVITIES ENCOMPASS-ED WITHIN EACH RESEARCH AND CONTROL OBJECTIVE .

MIN \ISSEMINN1 DISSE ED CANCER318 b 8 O

7 / AND U ECAVAIIVE 31 0NV SO QUES ARE A Nl CARE

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11

NATIONAL RESOURCES FOR CANCER RESEARCH - FISCAL YEAR 1973

32p,700,000 (4OURCES $320,

' SO

STATE AND LOCALGOVERNMENTS$96,200,0000Z8%)

OTHERFEDERALAGENCIES$90,200,000

VOLUNTARYAGENCIES$95,400,000

$21,800,STI$21,

%)

Y (2.2TRO ,100,

NATIONAL CANCER INSTITUTE$431,245,000

(57.4%)

245,0431,

NA L CANCER I _Add

57. 4%

O90

1200

SOURCE : Analysis of Mid-Range Resources Requirements for the National Cancer Program, March 1973, with adjustment for cost-of-living increases .

20

TOTAL: $751,945,000

tom

NCI BUDGET ADMINISTRATION PROCESS - UNDER CANCER ACT OF 1'971

2NOTE:SIMULTANEOUS ACTIVITIES BY MORE THAN ONEORGANIZATION INDICATE COOPERATIVE EFFORTS

LEGEND : o OPERATION . REVIEW & DECISION

BUDGET PHASE PRELIMINARY PLANNING PRESIDENT'S ACQUISITION OF APPORTIONMENT(CALENDAR FORMAL ESTIMATE TO OMB BUDGET APPROPRIATION & EXECUTION

TIME), t" AND ESTIMATE

(JULY-JUNE)(JANUARY-JULY) (AUGUST-DECEMBER) (JANUARY) ,(JANUARY-JUNE)ORGANIZATIONREVIEW NATIONAL REVIEW

NCI CANCER PROGRAMPLAN-UPDATE GOALS,ESTIMATES'AND DEVELOP

PARTICIPATEIN BUDGET PREPARE NCI PORTION OF

PREPARE CONGRESSIONAL ISSUE ALLOW-PRIORITIES,PRIORITIES, ETC. PRELIMINARY PREPARE FORMAL HEARINGS PRESIDENT'S BUDGET JUSTIFICATION ( REQUEST QUARTERLY

I ANC TO PRO-MS- BUDGET OMB SUBMISSION PARTICIPATEIN

APPORTIONMENT Of GRAMS

AND STAFF _ APPROPRIATIONSFUNDS

DIVISIONS HEARINGSDEVELOPESTIMATES

NATIONALCANCER

COMMENT ONADVISORY PRELIM(- REVIEW

BOARDNARY BUDGET AND COM-

MENT ONOMB SUB-MISSION

I PARTICIPATE" '

INS=

NIHREVIEW ANDCOM-MENT0OMB SUB- ' 'MISS( ON

SUBMITCONGRESSIONAL. ,D JUSTIFICATIONTO O

R FORPRE.,.

DHEW A PARTICIPATE IN0 APPROPRIATIONSMI HEARINGS

RECOMMEND FINALIZEREVIEW NCI ALLOWANCES PRESIDENT'S

-BUDGET BUDGET QUARTERLYOMB DOCUMENT APPORTIONMENT

.SET NCI REQUESTESTIMATESAPPORTIONMENTCONDUCT ALLOWANCE FROM NCI OF FUNDSBUDGET AND ADVISEHEARINGS NCI

SIGN LABOR-DHEWPRESIDENT ALLOWANCE PREPARE BILL IATIONSREVIEW BUDGET 'TRANSMIT I . INTO LAW

RECOMMENDATIONS MESSAGE BUDGET TOAND MAKE BUDGET TO CONGRESS CONGRESSDECISIONS

APPROPRIATIONS TRANSMIT LABOR-DHEWCONGRESS ACTION PASS FINAL BILLTO PRESIDENT APPROPRIATIONS

'LABOR DEWAPPROPRIATIONS BILL

ILLINOIS OHIO~-

INDIANA 44 $1,933,670$4,045,508 © $3,668,099

©$4,,0 0$1,170,451©$1,316,000

979 m30

J KENTUCKY

9

$443,541$259,782 VIRGINIAEE

1

WYORKNE

339 $44,857,324"m$11,699,000

0

®$23,142,703'$13,975,00076

DISTRIBUTION OF GRANT AND CONTRACT DOLLARS -- FISCAL YEAR 1973

SYMBOL KEY11 TOTAL NO. OF GRANTS & DOLLARS PER STATE

TOTAL NO. OF CONTRACTS & DOLLARS PER STATE

12 $3,077,66817 $4,979,000

FL PO IDA

© $173,355© $46,225PUERTO RICO

s

, 0$365,773© $179,857

'© $1,364,478-13$10,411,000

NORTH CAROLINA c

SOUTHCAROLINA

0$298,5141 $55,000

()$3,639,731©;$2,321,000

10$375,784I© $131,510,

I©$1,459,1421 $39,450`OD$5,373,279

$618,999

24 $1,328,476M$4,809,000

51 $11,103,105$30,32%00069

DISTRICT OF COLUMBIA

26 $6,550,429M($4,726,000

FOREIGN RESEARCH GRANTS ANDCONTRACTS - FISCAL YEAR 1973 , (THOUSANDS OF DOLLARS)

COUNTRY NUMBER OF'GRANTSNUMBER OFCONTRACTS

TOTALAMOUNT

PERCENT OFTOTAL AMOUNT

AWARDED

Australia 1 2 $: 291 6.3,

Austria - 1 22 .5

Belgium 1 1 40 .9

Canada 4 4 293 6.3

Colombia, S.A. - 2 104 2.2

England 2 3 245 5.2

France 1 2 747 16.0

Germany - 1 57 1 .2

Israel 1 11 1,332 28.6

Italy 1 5 334 7.2Japan - 3 224 4.8

Netherlands - 3 252 5.4

Portugal 1 - 35 .7

South Africa - 1 36 .8

Sweden 2 7 469 10.0

Switzerland 2 77 1.7

Uganda - 2 101 2.2

TOTALS 16 48 $4,659* 100.0

ANNUAL APPROPRIATIONS - 1938-1974

24 .

1938 . . . . . . . . . . . $

400,0001939 . . . . . . . . . . . 400,0001940 . . . . . . . . . . . 570,0001941 . . . . . . . ., . . 570,0001942 . . .,,, . . . . . 565,0001943.,, . . . . . . . . 534,8701944 . ., . . .,, ., . 530,0001945,, . . . . . . . ., 561,0001946.., . ., .,,,, 548,7001947 . .,,,,,, ., . 1,820,9001948,..,,, .,,, . 14,500,000 15 .1949, ., ., . ., . ., 22,000,000

41,$574,841,220

1950 .,, . . . . . . ., 24,900,0001951 . . ., . .,, . . . 20,086,0001952 ., ., . ., . . . . 19,656,7501953 . . . ., . . ., ., 17,887,0001954 .. . . . . . . . ., 20,237,0001955 . . . . . . . . . . . 21,737,0001956 ...,, . . . . . . 24,978,0001957 .. . . . . . . . . . 48,432,0001958. . . . . . . . . . . 56,402,0001959 .. . . . . . ., . . 75,268,0001960 . .. . . . . . . . . 91,257,0001961 . . . . . . . . . . . 111,000,0001962 . .. . . . . . . . . 142,836,0001963 . .. . . . . . . . .

155,742,0001964 . . . . . . . . . . .

144,340,0001965 . . . . . . . . . . . 150,011,000 46.3%1966 . . . . . . . . . . .

163,768,000 \ $1,721,727,563

1967 ........... 175,656,0001968. . . . . . . . . . . 183,356,0001969 . . . . . . . . . . . 185,149,5001970 . . . . . . . . . . . 190,486,0631971 . . . . . . . . . . . 230,383,000

38.2% lá IL 1972 ...........378,794,000$1,422,190,500 AX \ 1973 ��492,205,000

1974. . . . . . . . . . 551,191,500

TOTAL $3,718,759,283

NCI PROGRAM STRUCTURE -- FISCAL YEAR 1974

(THOUSANDS OF DOLLARS)

TOTAL DOLLARS$589,155(estimate)

CO

NT C'>

Ó ERR

CAUSE &PREVENTIONRESEARCH$145,986(24.8%)

CANCER CONTROL$34,599(5.9%)

CONSTRUCTION$45,340(7.7%)

SEA ,010

RE $24,

ó4O

ell

DETECTION

DIAGNOSISRESEARCH$39,275(&7%)

CANCERBIOLOGY$88,678(14.5%)

TREATMENTRESEARCH$194,689(33.01/6)

,90

DEVEL

RESEAR

s 628

000 %

*Includes research that cannot reasonably be classified in any one of the other research thrusts, but where output has potential application to all thrusts.**Planning and core support of centers .

25

OBLIGATIONS BY BUDGET ACTIVITY

RESEARCH

RESOURCE DEVELOPMENT

CANCER CONTROL


Cancer Control . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ., . . . ., . . . .

5,512

34,599

45,814

Total NCI

$ 431,245

$ 589,155

$ 600,000

*Includes research that cannot reasonably by classified in any one of the other research thrusts, but where output has potential application to all thrusts .

NOTE : These distributions include a proportionate share of NCI Management and NIH Management Fund .

26

Cause and Prevention . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $ 116,234 $ 145,986 $ 151,662Detection and Diagnosis ., . . . . . ., . ., ., . . . ., . . . ., 27,135 39,275 41,744Treatment. . . . . .. . . . ., ., ., . . . . . . . ., ., . ., ., ., . ., ., ., . ., . . . ., ., . 147,025 194,689 203,128Cancer Biology* . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 66,216 85,678 89,321

Total Research 356,610 465,628 485,855

Cancer Center Support . . ., ., . . ., . . . ., . . . ., . . . . . ., 15,840 19,578 23,484Research Manpower Development ., ., ., 14,132 24,010 22,530Construction . . . . . . . ., ., ., . . . ., ., . . . ., ., ., . ., ., . . . ., . . . ., ., . 39,151 45,340 22,317

Total Resource Development 69,123 88,928 68,331

1973 1974 1975BUDGET ACTIVITIES ACTUAL ESTIMATE ESTIMATE

NATIONAL CANCER INSTITUTE1974 BUDGET BY ORGANIZATION


$283,558

$40,524

$75,779

$111,980

$77,314

PERCENT

DIVISION OF CANCER TREATMENT

DIVISION OF CANCER CAUSE AND PREVENTION

OFFICE OF THE DIRECTOR

*Includes $2,990,000 carry forward of Fiscal Year 1973/1974 funds.

$ 1,536 Supporting Services .315,650 Program Direction 2.616,940 Management Fund 2.99,133 Direct Construction 1,5

34,055 Cancer Control 5.8

$589,155* TOTAL 100.0

AMOUNT ACTIVITY OFTOTAL

DIVISION OF CANCER RESEARCH RESOURCES AND CENTERS

$115,153 Regular Program 19.5776 General Research Support ,1

91,155 Cancer Research Centers 15,510,503 Task Forces 1,823,643 Fellowship and Training 4,02,099 Research Career Programs .4

35,900 Construction 6.14,329 Review and Approval .7

DIVISION OF CANCER' BIOLOGY AND DIAGNOSIS

$ 32,153 Laboratory and Clinical Research 5.58,371 Task Forces 1.4

66,493 Virus Cancer Program 10,335,850 Carcinogenesis 6.110,722 Demography 1.84,915 Task Forces ,8

CANCER CONTROL OBLIGATIONS

PREVENTION$901,000

DIAGNOSISAND

TREATMENT$1,505,000

EARLYDETECTION$3,106,000

Fiscal Year 1973$5,512,000

Fiscal Year 1974$34,599,000(estimate)

TASK FORCE OBLIGATIONS - 1966 -1974

SRQJO0OSGZQSOT

26,000

24,000

22,000

20,000

18,000

16,000

14,000

12,000

10,000

8,000

6,000

4,000

2,000

BREAST CANCER TASK FORCE

LUNG CANCER TASK FORCE

BLADDER CANCER TASK FORCE

LARGE BOWEL CANCER TASK FORCE

PROSTATE CANCER TASK FORCE

1966 1967 1968 1969 1970 1971 1972 1973 1974FISCAL YEAR

(est.)

29

REIMBURSEMENT TO NIH MANAGEMENT FUNDFISCAL'' YEAR 1974

4.6 43.6%

$778,000

$65,942,000TOTAL NIH SERVICES

DISTRIBUTION OF NCI SERVICES$16,975,000

30

21 .0 14.8% 6 .6

$2,509,000

9.4 $1,594,000

$1,122,000

CLINICAL CENTER

Service FunctionsSocial WorkProfessional Services

Consultative ServicesAdmissions and Follow-upAnesthesiologyDiagnostic X-RayClinical PathologyBlood BankRehabilitation ServicePharmacy ServiceMedical RecordsTV Engineering

Nursing ServicePatient Nutrition ServiceEnvironmental Sanitation

ControlLaundryRadiation Safety

OFFICE OF ENGINEERING SERVICES

Research Facilities PlanningPlant Engineering ServicesLiaison & Inspection of Projects

DIVISION OF RESEARCH GRANTS

Initial Scientific Review ofApplications

Assignment of Research GrantApplications Among Institutes

DIVISION OF RESEARCH SERVICES

Laboratory AidsAnimal Hospital

DIVISION OF COMPUTER RESEARCH OFFICE OF ADMINISTRATIVE SERVICES Media Preparation& TECHNOLOGY Glassware Preparation

Office Services Comparative PathologyResearch & Development Program Plant Safety Germ-free Animal Production

in Which Concepts & Methods of Supply Management Biomedical Engineering andComputer Science Are Applied to Financial Management InstrumentationBiomedical Problems (Services Are Personnel Management Library ServicesRendered to the NIH Communities Management Policy Medical Artson a Fee-For-Service Basis). Management Survey and Review Environmental Services

NATIONAL CANCER INSTITUTE OBLIGATIONS AND EXPENDITURES

O

650,000

600,000

550,000

500,000

450,000

ARS 400,000O° 350000,

D 300,000aS

250,000T

200,000

150,000

100,000

50,000

1968 1969 1970 1971 1972 1973 1974FISCAL YEAR

(estimate)

OBLIGATIONS: Orders placed, grants and contracts awarded, salaries earned and similar financial transactions which legally utilize or reserve an appropriation for expenditure.

EXPENDITURES : Payments (cash or checks, made from current or prior year appropriations.

DISTRIBUTION OF PERSONNEL BY FUNCTION

700

600

500

400

300

32

1967 1968 1969 1970 1971 1972 1973

........ Scientific

- Administrative

Technical and Supporting

Percent of Actual Employment

Fiscal Year

1967 1968 1969 1970 1971 1972 1973

Scientific 33.9% 37.5% 37.8% 38.3% 37.5% 36.2% 37.3%

Administrative 27.5% 25.5% 24.4% 24.0% 23.9% 27.3% 27.6%

Technical and Supporting 38.6% - 37.0% 37.8% 37.7% 36.6% 36.5% 35.1%

Total Actual Employment 1329 1453 1411 1355 1426 1665 1736

COMPARISON OF DOLLARS, PO

1971

1972

1973

1974(estimate)

1975(estimate)

*Does not include field station-assigned space.

S AN SPACE

DOLLARS POSITIONS SPACE

PERCENT OF PERCENT OF FULL-TIME PERCENT OF PERCENT OF ALLOCATED PERCENT OF PERCENT OFOBLIGATIONS INCREASE INCREASE PERMANENT INCREASE INCREASE SPACE INCREASE INCREASE

($000'5) OVER OVER EMPLOYEES OVER OVER (SQUARE OVER OVERBASE YEAR PRIOR YEAR BASE YEAR PRIOR YEAR FEET)* BASE YEAR PRIOR YEAR

Base Base Base232,855 year 1426 Year 321,230 year

378,636 62.6 62.6 1665 16.8 16.8 329,587 2.6 2.6

431,245 85.2 13.9 1736 21 .7 4.3 357,972 11 .4 8.6

589,155 153.0 36.6 1820 27,6 4.8 384,972 19.8 7.5 .

600,000 157.7 1 .8 1855 30.1 1.9 390,272 21.5 1 .4

$12,053,

RESEARCHGRANTS

$120,150,000(49.6%)

RESEARCHSUPPORTCONTRACTS$70,094,000

(28.9%)

EARCHGRANTS$157,663,00 0(53

oJ

$10,136,000

RESE9,Q01 6,

RESEARCHCONTRACTS$39,902,000(16.5%)

RESEA

CH GRANTS $120,150Ó

RCH SUPPORT CGN

RESEARCHGRANTS

$157,663,000(53.7%)

RESEARCHGRANTS

$217,587,000(54.7%)

$11,832,000

RESEARCHCONTRACTS$88,005,000

(22.1%)

RESEARCHSUPPORT

CONTRACTS$80,532,000(20.21/° )y

SUPPORT CONTRAC

537,0000

COMPARISON OFRESEARCH GRANTS/RESEARCH ANDRESEARCH SUPPORTCONTRACTS

1972$242,199,00

INTERAGENCYAGREEMENTS$12,053,000

(5.0%)


(3.4% /o)


(3.0%)

1973$293,824,000

m .9

1974RESEA

O 6,025,000ARCH GRANTS $217,, $397,956,000

AR CH

SUPPORT CONTRACTSRESE 7, o0̀

4.7%óJ

TOTAL NCI DOLLARS BY MECHANISMS - FISCAL YEAR 1974

TOTAL$589,155,000

INTERAGENCY AGREEMENTS$11,832,000 (2.0%)

26

RESEARCH$35,561,000

(6.0%)

NCI/NIH MANAGEMENT$33,086,000 (5.6%)

w

v 25,724, ACTIVr

GRANTS $293,279,000 149'8

ó

RESEARCH$88,005,000

(14.9%)

RESEARCH GRANTS$217,587,000

(36.9%)

$7,050,000 (1.2%)

NOTE : Management includes NCI Management as well as NIH Management Fund .

CANCERCONTROL

NCI/NIHMANAGEMENT

35

(36.6%)1

1 ,000$215, 3g

1(1

TROL

RESEARCHSUPPORT

ERo 000$80,532,000

(13.7%) O2 000

RESEARCH POSITIONS AT THE NATIONAL CANCER INSTITUTE'

1. CIVIL SERVICE .

The National Cancer Institute recognizes that one of the most valuable resources tobe drawn upon in the fight against cancer is the wealth of scientific talent availablein the U.S . and around the world. In an effort to attract and maintain the highestquality scientific staff, two personnel systems are used : the U .S . Civil ServiceSystem and the PHS Commissioned Corps. In addition, the Staff Fellowship Programand the NIH Visiting Program have been designed to meet special needs. Specialprograms are also available for those who qualify.

POSITION)

-

ELIGIBILITY

ANNUAL SALARYMECHANISM OF ENTRY

11 .

SPECIAL APPOINTMENT OF EXPERTS AND CONSULTANTS

III. USPHS COMMISSIONED CORPS

36

Associate Training Program including CORD residency deferment program (limited tenure, maximum 3 years)2

Clinical Associate Graduates of Medical Schools in- Pay and allowances of Apply to ClinicalI

and Professionalcluding Internship Senior Assistant Surgeon Education Section, Clinical Center,

or Surgeon of PHSSurgeon

National Institutes of Healthmissioned Corps

B. Research Associate Graduates of Medical Schools in- Pay and allowances of Apply to Clinical and Professionalcluding Internship Senior Assistant Surgeon Education Section, Clinical Center,

or Surgeon of PHS tom- National Institutes of Healthmissioned Corps

Staff Associate Graduates of medical and dental Pay and allowances of Apply to Clinical and Professionalschools, or other doctoral Senior Assistant Surgeon Education Section, Clinical Center,qualifications of PHS Commissioned National Institutes of Health

Corps.

D. Senior COSTEP Senior Medical Students Pay and Allowances of Apply to Clinical and ProfessionalProgram (Medical) Junior Asst. Health Ser- Education Section, Clinical Center,

vice Officer plus payment National Institutes of Healthof tuition, fees and othernecessary expenses . Can-didates incur 2 year ac-tive duty obligation withPHS CommissionedCorps.

A., Civil Service Appropriate advanced education, ex- Minimum starting: Civil Service Commission. Contact(tenured) perience and knowledge needed by Ph.D. - $20,677 Director or Laboratory Chief in area of

NCI to conduct its programs Physicians - $26,189 interest or the NCI Personnel Office.Maximum: $36,000

A. Special Appointment of Applicants shall possess outstanding Equivalent to the salary Recommendation by Division Direc-Experts and Con- experience and ability such as to range of GS-16 through tors. Final approval rests with thesultants (non-tenured justify recognition as authorities in GS-18 Director, NCI.appointment which can their particular fields of activity .be extended up to 4 Maximum: $36,000years)

IV. VISITING PROGRAM (limited tenure)3

V. STAFF FELLOWSHIPS

VI. SPECIAL PROGRAMS ;

1 Does not necessarily indicate that positions are currently available at the National Cancer Institute.2 Appointments are made upon intellectual attainment and demonstrated research interest and ability matched to NCI's needs .3 Under most circumstances, the various visiting programs are limited to non-citizens .

37

POSITION ELIGIBILITY ANNUAL SALARY ; MECHANISM OF ENTRY '

A. Visiting Fellow 1-3 vears postdoctoral education $7,000-10,000 plus Contact Director or Laboratory Chief(maximum 3 years) $1,000 for each of first in area of interest .

two dependents and $500for each additionaldependent

B. Visiting Associates 3+ years postgraduate education $12,000-17,500 Contact Director or Laboratory Chief(1 year with renewals to' with appropriate knowledge needed in area of interest.end of project) by NCI

C. Visiting Scientist 6+ years postdoctoral education $20,000-36,000 Contact Director or Laboratory Chief(duration of project) with appropriate unusual experience in area of interest .

and knowledge needed

A. Staff Fellowships Physician or other doctoral degree Staff Fellows Contact Director or Laboratory Chief(maximum 6 years) equivalent awarded within last 5 Ph sicians in area of interest or the NCI Per-

years, U.S. citizen or non-citizen 17,900-21,500 sonnel Office.eligible for naturalization within 4 Other Doctoratesyears. $13,700-20,000

Senior Staff FellowsPh sicians

20,200-28,200Other Doctorates

$17,900-22,800

A. Research Fellow spon- Determined by sponsoring Established by spon- Contact Director or Laboratory Chiefsored by organization

Iorganization. spring organization in area of interest; also apply to spon-

other than NIH, PHS spring agency, e.g. American CancerSociety, Eleanor Roosevelt Cancer .Foundation, Leukemia Society ofAmerica, Inc., etc.

B. COSTEP Program (oper- U.S. citizen with 2 years of bac- Pay and allowance of a Apply to PHS Commissioned Corps,ates year-round) Max- calaureate program or more in Commissioned Officer, COSTEP SECTION, Parklawnimum 120 days per 12' health-related field: May be enrolled Junior Asst. Grade Building, 5600 Fishers Lane, Rock-month period in doctoral program or professional ville, Maryland 20852.

school . Physical requirements of - --PHS Commissioned Corps. Plans toreturn to college .

C. Civil Service U.S. citizen, 18 years of age or older Pay equivalent to GS-1 Civil Service Summer EmploymentSummer Employment (16 if high school graduate) through GS-4 depending Examination (waived for outstandingProgram on education and ex- 3rd year college engineering or

perience physical science students)

College graduates, graduate Pay equivalent to GS-5 Apply to NIH Personnel Staffingstudents, faculty members, through GS-12 Branch.equivalent experience .

D. Fogarty International International reputation, produc- $30,000 per annum Recommendation to Fogarty CenterScholars tivity, demonstrated ability in by Institute Director or Scientist

biomedical field Contact Director in area of interest.

W38

NCI CONTRACTS ADMINISTRATION PROCESS - UNDER CANCER ACT OF 1971

TIME

I

MONTHS

0 1 2 3 4 5 6ORGANIZATION

PROGRAM

ADVISORY

GROUPS ADVISEPROGRAM,STAFF

DEVELOP PREPAREPROJECT I PROPOSALSITE VISITS ANOREVIEW,

PROGRAM ,PEN

MENTS WORK STATE AND PREPAREPROPOSAL

NCI PROGRAM ESTABLISH OBJECTIVES SPECIFICATIONS EVALUATE'SUMMARY

ADMINISTER

STAFF .PROJECT AREAS . ESTABLISH

PROJECT RELEVANCE, SET PRIORITIESRESUMES A IL NEGOTIATECONTRACT CONTRACT

III PROPOSAL REVIEW,

NCI RESEARCH ADVERTISE PROJECTSSITE VISITS ANDPREPAREPROPOSAL EXECUTE CONTRACT

ANDAWARD ADMINISTERPREPARE WORK IN CBO EVALUATE'

SUMMARY CONTRACTCONTRACTS, STATEMENTSAND RESUMES

SPECIFICATIONS '- QUALIFIED NEGOTIATEBRANCH SGURCES CONTRACT

CONTRACTOR . CUTE'CONTRACT

SUBMITRESUMES SUBMIT

NEGOTIATECONTRACT

PROPOSAL

CONTRACT I C RECO TRACTORREVIEW REVIEW PROPOSALS

COMMITTEEFORMERIT

SCIENTIFIC

NOTE :LEGEND

SIMULTANEOUS ACTIVITIES BY MORE THAN ONEORGANIZATION INDICATE COOPERATIVE EFFORTS, -OPERATION NORMALFLOW

-REVIEW NON-COMPETITIVE CONTRACTS

- DECISION AD HOC COMMITTEES MAYBEUSED -INCLUDES OUTSIDE SCIENTISTS

CONTRACTORS RECEIVING MORE THAN $750,000 IN NCI

(THOUSANDS OFRESEARCH CONTRACT FUNDS -- FISCAL YEAR 1973DOLLARS)

SUBTOTAL -

2691

$ 92,271241 Contractors receiving MORE than $750,000 (listed above)SUBTOTAL -

427

48,859

214 Contractors receiving LESS than $750,000 (not listed)

696 $141,130

1269 represents 39% of the 696 contracts awarded.

'2$92,271,000 represents 65% of the $141,130,000 awarded in FY 1973 .

39

PERCENT OF NUMBER OF AMOUNT CONTRACTOR STATETOTAL DOLLARS CONTRACTS

21 $ 16,515 Litton Bionetics Maryland12 6,311 Microbiological Associates Maryland11 4,076 Southern Research Institute Alabama14 3,950 Hazleton Laboratories Virginia4 3,465 Flow Laboratories Maryland35%1 3,446 University of Nebraska Medical Center NebraskaC

0 11 3,435 Meloy Laboratories Virginia16 3,109 Atomic Energy Commission Tennessee5 3,023 University of Southern California California4 2,862 American Health Foundation New York

7 2,660 Arthur D . Little, Inc . MassachusettsS 1 2,490 U.S . Public Health Service Marylandm

9 2,275 Stanford Research Institute California11 2,187 University of Texas M.D . Anderson Hosp . Texas1 2,160 Veterans Administration Dist. of Col .3 2,045 Pfizer, Inc . New Jersey

20 12 2,033 Mason Research Institute Massachusetts7 2,027 Illinois Institute of Technology Illinois5 1,718 California State Dept . of Public Health California5 1,432 St . Louis University Missouri

3 1,384 Life Sciences, Inc. Florida4 1,370 Battelle Memorial Institute Ohiom5 1,245 Columbia University New York4 1,199 Electro-Nucleonics Laboratories Maryland7 1,104 University of Pennsylvania Pennsylvania

45 3 1,084 Charles River Breeding Laboratories Massachusetts2 1,080 JRB Associates Virginia8 1,044 Johns Hopkins University Maryland8 1,042 Midwest Research Institute Missouri10 1,010 Mayo Foundation Minnesota

7 972 University of California Los Angeles California5 959 A. R . Schmidt Company Wisconsin9 928 University of Minnesota Minnesota3 905 Upjohn Company Michigan8 895 University of Chicago Illinois2 871 Merck and Company New Jersey7 840 New York University New York4 793 Bristol Laboratories New York6 789 Dow Chemical Company Michigan4 788 University of Pittsburgh Pennsylvania

10 750 National Academy of Sciences Dist . of Col .

DISTRIBUTION OF CONTRACTS BY NCI PROGRAM AREAAND BY TYPE OF INSTITUTION - FISCAL YEAR 1973

40

PERCENT OFTOTAL NUMBEROF CONTRACTS

NUMBER OFCONTRACTS NCI PROGRAM AREA

THOUSANDSOF DOLLARS

225Division of Cancer $ 43,866Treatment

336 Division of Cancer Cause 77,649and Prevention

116 Division of Cancer Biology 14,646and Diagnosis

19 Cancer Control 4,969

696 Total $141,130

TS ADMINISTRATION

NOTE: SIMULTANEOUS ACTIVITIES BY MORE THAN ONEORGANIZATION INDICATE COOPERATIVE EFFORTS

UNDER CANCER ACT OF 1971w, ~ x

LEGEND :

OPERATIONS

REVIEW

- DECISION

NORMAL ADMINISTRATIVE FLOW

©

APPLICATIONS LESS THAN $35,000 TOTAL COSTS (TIME SAVING 3 TO 4 WEEKS)

------- * SITE VISITS REQUIRED FOR ONLY ABOUT 10% of APPLICATIONS

NCAB MEETS NOT LESS THAN 4 TIMES PER YEAR

TIME (MONTHS)ORGANIZATION

0 1 2 3 4 5 8 7 8

PREPAREIPARTICIPATE 1N

APPLICATION NEGOTIATIONSAPPLICANT RECEIVEINSTITUTION

NOTICE OF AWARDRECEIVE RECOMMENDATIONS RECEIVEDNOTICE OF

o oIN

ASSIGN RECOMMENDATIONS NEGOTIATIONSAPPROPRIATE AWARD

oNCI/DCRRC APPLICATIONS FUNDING RECEIVED NEGOTIATIONSSUBMITS TO NCI REVIEW DETERMINATIONS AND FINAL

DIVISION OF GUIDELINESINES IDENTIFIES COMMITTEEMADE ¡ REVIEW

CANCER RAM _ o SUMMARY ---o-- .10RESEARCH

RELEVANCE_

ASSIGN TO ATTENDTS

MAILED STATEME TOAWARD

f NEGOTIATIONS AWARD STATEMENTESTABLISHESPROGRAM PROGRAM IRG MEETING NCAB MEMBERS

AND FINAL STATEMENTPREPARED AND PREPARED ANDRESOURCES AREAS DIRECTOR AS OBSERVER REVIEW . MAILED MAILEDAND CENTERS DEVELOPS o FUNDING- NCI - PROGRAM ATTEND

ODEETERMINATIONSOBIEC TIVES

PICASASSIGN TO MEETING

DIVISION OF INSTITUTE

RESEARCHGRANTS ASSIGN

APPROPRIATE- NIH (DRG) - DETERMINE APPLICATIONSRESEARCH To INITIALAREA REVIEW GROUP (IRG), SUMMARY

STATEMENTSPREPARED

INITIAL SECRETARYEXECUTIVE_ _ _

oEXECUTIVEREVIEW REVIEW IRGMEMBER /* IRG MEETING SUMMARY SECRETARIES

AND REVIEW VOTE STATEMENTS ATTEND NCABGROUP REVIEW SITE VISIT AND ASSIGN PRINTED MEETINGREPORT /

'PRIORITY

- NIH (IRG) -o-----o

SITE VISIT-

NATIONALCANCERADVISORY **CONSIDERAPPLICATIONSBOARD AND MAKE

RECOMMENDATIONS

INSTITUTIONS RECEIVING MORE THAN $750,000 INNCI RESEARCH GRANT FUNDS - FISCAL YEAR 1973


48 Institutions receiving MORE than $750,000 (listed above)

234 Institutions receiving LESS than $750,000 (not listed)

11,060 represents 63% of the 1692 grants

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