PREFACE
The information set forth in this publication is
compiled and amended annually by the National
Cancer Institute and is intended primarily for use
by members of the Institute staff, the principal ad-
visory groups to the Institute and others involved inthe administration and management of the National
Cancer Program. Questions regarding any of the in-
formation contained herein may be directed to the
Financial Manager, National Cancer Institute, 9000
Rockville Pike, Bethesda, Maryland 20014.
Revised January 1974
National Cancer InstituteFACT BOOK
1974
DHEW Publication No . (NIH) 74-512
INSTITUTE DATA
Directory of Personnel . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . .
v
National Cancer Institute Historical Data : Legislative Highlights . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . ..
1Historical Events . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . .. . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . . . . . . . . . ..
2
Biographical Sketches of NCI Directors . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . . . . . . . .
2
President's Cancer Panel . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . . .
4National Cancer Advisory Board . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . .. . . . . . . . . . . . . .
5National Cancer Institute Executive Committee . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . . . . . .
6Organization Charts:
National Cancer Institute Organization . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . .. . . . . .. . . . . . . .
7National Cancer. Institute . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . .
8Division of Cancer Cause and Prevention. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . .
9Division of Cancer Biology and Diagnosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ..
. . .. . . . . . . . . . . . . .. . . . . . . . . . . . . . . . .. . . . . .. . . . .. . . . . .. . . 10Division of Cancer Treatment . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 11
Division of Cancer Research Resources & Centers . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . -12
Building Location and Square Footage Occupied . . . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . .. . . . 13
Cancer Statistics . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . 14
National Cancer Program Strategy Hierarchy. . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . . . . . . . . . . . .. . . . 18
National Resources for Cancer Research . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . .. . . . . . . . . . . . . . . . . . . . . . .. . .. 20
BUDGET DATA
Budget Administration Process . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . .. . . . . . . . . . . . . . . . . . . . . .
21Distribution of Grant & Contract Dollars . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . .. . . . . .. . . . . . . . . . . . . . . . 22Foreign Grants and Contracts. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . .. . . . 23Annual Appropriations 1938-1974. . . . . . . . . .. . . . . . . . . . . . ... .. . .. . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . ... . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . 24NCI Program Structure . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . .. . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . 25Appropriations by Budget Activity . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . .. . . . . . . . . . . . . . : . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . .. . . . . . . . . . . . . . 261974 Budget by Organization . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . 27
Cancer Control Obligations . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 28
Task Force Obligations .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 29
Reimbursement to NIH Management Fund . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . .. . . . . . . . . . . . . .. . .. . . . . . 30Obligations and Expenditures 1968-1974 . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 31
Distribution of Personnel 1967-1974 . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . : . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . . . .. . . . . . . . . . .. . . . 32
Comparison by Dollars, Positions and Space . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . .
33Comparison of Research Grants/Research & Research Support Contracts . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . .
34Total NCI Dollars by Mechanisms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . 35Research Positions at the NCI . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . 36
CONTRACT DATA
PAGE
Contracts Administration Process. . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . .
38
Contractors Receiving More Than $750,000 .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . 39
Distribution of Contracts. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . .. . . . . . .. .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . 40
GRANT DATA
Grants Administration Process . . . . . . . . . .. . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . .
41Institutions Receiving More than $750,000 . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . .. . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . 42Distribution of NCI Research Grants by Value of Grant Award . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . .
43
NCI Grant Awards 1965-1974 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44
NCI Grant Dollar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . 45Location of Comprehensive and Specialized Centers and Exploratory Projects . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . 46
DIRECTORYOF
PERSONNEL
NATIONAL CANCER INSTITUTENATIONAL INSTITUTES OF HEALTHBETHESDA, MARYLAND 20014Area Code 301/656-4000
EXTENSION
DIRECTOR
BUILDING 31Dr. Frank J . Rauscher, Jr .
11-A-52
65615DEPUTY DIRECTOR
BUILDING 31Dr. Guy R . Newell
11-A-52
63505ASSISTANT DIRECTOR
BUILDING 31Dr. Bayard H. Morrison III
11-A-51
63308ASSISTANT DIRECTOR
BUILDING 31Dr. Richard A . Tjalma
11-A-46
65854CLINICAL DIRECTOR
BUILDING 10Dr. Alfred S . Ketcham
10-N-116
64164ASSOCIATE DIRECTOR FOR PROGRAM PLANNING AND ANALYSIS
BUILDING 31Mr. Louis M. Carrese
11-A-49
66445ASSOCIATE DIRECTOR FOR CANCER COMMUNICATIONS
BUILDING 31Mr. Frank Karel III
11-A-31
61911ASSOCIATE DIRECTOR FOR CANCER CONTROL
BLAIR BUILDINGDr . Diane J . Fink732A 427-7997
ASSOCIATE DIRECTOR FOR INTERNATIONAL AFFAIRS
BUILDING 31Dr . Gregory T . O'Conor
11-A-19
61932ASSOCIATE DIRECTOR FOR ADMINISTRATIVE MANAGEMENT
BUILDING 31Mr. Calvin B . Baldwin, Jr.
11-A-46
65737CHIEF, ADMINISTRATIVE SERVICES BRANCH
BUILDING 31Mr. Thomas L. Kearns
11-A-29
65801CHIEF, FINANCIAL MANAGEMENT BRANCH
BUILDING 31Mr. Earle L. Browning
11-A-18
65803CHIEF, PERSONNEL MANAGEMENT BRANCH
BUILDING 31Mrs . Rosemary H. Williams
3-A-32
61771CHIEF, RESEARCH CONTRACTS BRANCH
BUILDING 31Mr. Carl A . Fretts
10-A-20
63573
DIRECTOR, DIVISION OF CANCER CAUSE AND PREVENTION
BUILDING 31Dr. James A. Peters
11-A-03
66618ADMINISTRATIVE OFFICER
BUILDING 31Mr. John M. Miller
11-A-11
66556
DIRECTOR, DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
BUILDING 31Dr . Nathaniel I . Berlin
3-A-03
64346ADMINISTRATIVE OFFICER
BUILDING 31Mr. H. Kenneth Painter
< 3-A-05
63381
DIRECTOR, DIVISION OF CANCER TREATMENT BUILDING 31Dr . C . Gordon Zubrod
3-A-52
64291ADMINISTRATIVE OFFICER
BUILDING 31Mr . Charles E . Leasure, Jr .
3-A-50
65964
DIRECTOR, DIVISION OF CANCER RESEARCH RESOURCES AND CENTERS
BUILDING 31Dr . J . Palmer Saunders
10-A-03
65147CHIEF, GRANTS ADMINISTRATION BRANCH
WESTWOOD BUILDINGMr. Leo F. Buscher, Jr .
8-A-18
67753ADMINISTRATIVE OFFICER
BUILDING 31Mrs. Edith F. Phillips
10-A-10
65915
v
NATIONAL CANCER INSTITUTE HISTORICAL DATA
March 7, 1928-Senator M.M. Neely introduced S .3554, "To authorize the National Academy ofSciences to investigate the means and methodsfor affording Federal aid in discovering a curefor cancer and for other purposes."
April 12, 1937-Congressman Warren G. Magnusonof Washington introduced H.R . 6100, an iden-tical bill to S . 2067.
July 8, 1937 - A joint hearing of the Senate andHouse committees was conducted before aSubcommittee on Cancer Research, and arevised bill was written .
July 23, 1937 - The National Cancer Institute Actwas passed by Congress.
August 5,1937- The National Cancer Institute Act,Public Law 244, 75th Congress, was signed byPresident Franklin D . Roosevelt, "To providefor, foster, and aid in coordinating researchrelating to cancer; to establish the NationalCancer Institute ; and for other purposes." Anappropriation of $700,000 for each fiscal yearwas authorized.
July 1 . 1944 - The Public Health Service Act,Public Law 410, 78th Congress, provided that"The National Cancer Institute shall be adivision in the National Institutes of Health."The act also revised and consolidated manyrevisions into a single law. The limit of$700,000 annual appropriation was removed .
December 4, 1970 . Senator Ralph Yarborough,Texas, introduced S . 4564, "A bill which wouldestablish a National Cancer Authority for thepurpose of devising and implementing anational program for the conquest of theworld's most dreaded disease - cancer."
January 22, 1971 . In his State of the Union Message,__ President Nixon announced that he would ask
for the appropriation of an additional $100
LEGISLATIVE HIGHLIGHTS
million to launch an intensive effort to controlcancer, and that he would ask later forwhatever additional funds could be effectivelyused.
March through November, 1971 . Hearings on pro-posed legislation relating to cancer researchexpansion were held by both House and Senatesubcommittees .
October 18, 1971 . The President announced that theArmy's Biological Defense Research Center atFort Detrick, Maryland would be converted intoa leading center for cancer research as part ofthe major campaign to conquer cancer.
December 7, 1971 . After three conference sessionsthat began on November 30, the Senate-HouseConference Committee agreed on S . 1828.
December 9, 1971 . The House passed the bill byvoice vote .
December 10, 1971 . The Senate passed the bill 85-0and sent it to the President for signature .
December 23, 1971 - President Nixon signed P.L.92-218, The National Cancer Act of 1971,providing increased authorities and responsibilities for the NCI Director ; initiating aNational Cancer Program ; establishing a three-member President's Cancer Panel and a 23-member National Cancer Advisory Board, thelatter replacing the National Advisory CancerCouncil ; authorizing the establishment of 15new research, training, and demonstration can-cer centers ; establishing cancer controlprograms as necessary for cooperation withState and other health agencies in thediagnosis, prevention, and treatment of cancer;and providing for the collection, analysis, anddissemination of all data useful in thediagnosis, prevention, and treatment of cancer,including the establishment of an internationalcancer research data bank .
August 5, 1937 - President Franklin D. Rooseveltsigned the National Cancer Act.
November 9, 1937 -The National Advisory CancerCouncil held its first meeting.
January 13, 1938- Dr. Carl Voegtlin was appointedthe first Director of the Institute.
October 31, 1940- President Franklin D. Rooseveltdedicated Building 6.
July 1, 1947 - NCI reorganized to provide for ex-panded program; intramural cancer research,cancer research grants, and cancer control ac-tivities.
July 2, 1953- NCI inaugurated a full-scale clinicalresearch program in the new Clinical Center.
April 1955 - The Cancer Chemotherapy NationalService Center was established in the Instituteto coordinate the first national, voluntary,cooperative cancer chemotherapy program.
January 11, 1966 - NCI reorganized to coordinaterelated activities . The areas of three ScientificDirectors were established : Etiology ;Chemotherapy ; and a group of discipline-oriented laboratories and branches referred toas General Laboratories and Clinics.
February 13, 1967- A Cancer Research Center wasestablished in Baltimore USPHS Hospital toconduct an integrated program of laboratoryand clinical research on the therapy and man-agement of cancer patients .
April 27, 1970- At the request of Senator Ralph W.Yarborough, Chairman of the Committee onLabor and Public Welfare, the Senate approvedthe establishment of the National Panel of Con-sultants on the Conquest of Cancer .
Carl Voegtlin, Ph.D .
JANUARY 13, 1938 TO JULY 31, 1943
Dr . Carl Voegtlin, the Institute's first Director,was born in Zofingen, Switzerland, on July 28,1879 . He studied at the University of Basel, Univer-sity of Munich, University of Geneva, and received aPh.D . degree in 1904 from the University ofFreiburg .
2
HISTORICAL EVENTS
BIOGRAPHICAL SKETCHESOF NCI DIRECTORS
November 25, 1970 - The National Panel of Con-sultants submitted to the Senate Committee areport entitled "National Program for theConquest of Cancer."
October 18, 1971 - President Nixon converted theArmy's former biological warfare facilities atFort Detrick, Md., to research on the causes,treatment and prevention of cancer .
December 23, 1971 - President Nixon signed P.L .92-218, The National Cancer Act of 1971 .
June 22, 1972 - The Institute awarded a contractfor the operation and maintenance of theFrederick Cancer Research Center at FortDetrick, Maryland . This constituted the largestresearch contract ever awarded by a researchcomponent of the National Institutes of Health .
June 30, 1972 - A team of five U.S . cancer scien-tists met with Russian scientists in Moscow toexchange information on cancer drugs. Dr . C.Gordon Zubrod, Scientific Director forChemotherapy, NCI, on behalf of the UnitedStates, signed a U.S.-U .S.S.R . agreement forcontinued cooperation on the exchange ofdrugs, visiting scientists, and information.
July 27, 1972 - A Bureau-level organization wasestablished for the National Cancer Institute,giving the Institute and its componentsorganizational status commensurate with theresponsibilities bestowed on it by The NationalCancer Act of 1971 . Under the reorganization,the Institute was composed of the Office of theDirector and four Divisions: the Division ofCancer Biology and Diagnosis; Division of Can-cer Cause and Prevention ; Division of CancerTreatment; and Division of Cancer Grants .
Upon arriving in the United States in 1905, hebecame a chemistry instructor at the University ofWisconsin, and the following year went to JohnsHopkins where he remained until 1913 . Asprofessor of pharmacology and Chief of theDivision of Pharmacy at the Hygienic Laboratory,his cancer research was largely confined to thebiochemical aspects.
During World War II and for several years thereaf-
ter he was lecturer in pharmacology at the Univer-sity of Rochester, which conferred upon him anhonorary degree of Doctor of Science for his con-tributions to war and other research efforts .Dr . Voegtlin became Director of NCI on January
13, 1938, and held this post until his retirementfrom PHS on July 31, 1943. He retained an activeinterest in NCI until his death in -1960 .
AUGUST 1, 1943 TO JUNE 30, 1947
Roscoe Roy Spencer, M.D .Dr. Roscoe Roy Spencer was born in King William
County, Va., July 28, 1888, and received his M .D.degree from Johns Hopkins in 1913 . Beforebecoming NCI's first Assistant Chief, he was notedfor his contribution in the investigations of RockyMountain spotted fever . .Dr. Spencer became Director of NCI on August 1,
1943, and remained in this post until July 1, 1947 .He had assignments with PHS until his retirementi n
1952.
JULY 1, 1947 TO APRIL 6, 1948
Leonard Andrew Scheele, M.D.Dr. Leonard Andrew Scheele was born in Fort
Wayne, Ind ., July 25, 1907. He received an A.B .degree from University of Michigan and his M.D.degree from Wayne University.Upon entering PHS, he served as assistant
quarantine officer, health officer, special cancerfellow at Memorial Hospital in New York City, of-ficer-in-charge of the National Cancer ControlProgram, and Chief of Medical Division of CivilianDefense before becoming Assistant Chief of NCI in1946 .Dr . Scheele served as Director of NCI from July 1,
1947 to April 6, 1948, when he was appointedSurgeon General, PHS. Upon retirement from PHSin 1956, he became the president of Warner-Chilcott Laboratories, Warner-Lambert Phar-maceutical Co.
MAY 15, 1948 TO JUNE 30, 1960
John Roderick Heller, M.D .Dr . John Roderick Heller was born in Fair Play,
S.C ., on February 27, 1905, and received his M.D .degree from Emory University, Atlanta, Ga. He wascommissioned in PHS in 1934, and became Chiefof PHS's Venereal Disease Division beforebecoming Director of NCI on May 15, 1948, a postwhich he held until June 30, 1960. He then joined
the Memorial Sloan-Kettering Cancer Center in NewYork City as President and Chief Executive Officer,remaining in that position until February 1964.Subsequently he served as Vice Chairman of the
Board of Trustees of the Center and was specialconsultant on international, medical and scientificaffairs to the American Cancer Society . On August1, 1965, Dr . Heller returned to NCI as Special Con-sultant on International Activities .
JULY 1, 1960 TO NOVEMBER 9, 1969
Kenneth Milo Endicott, M.D.Dr. Kenneth Milo Endicott was born in Canon
City, Colo., June 6, 1916, and received his M.D .degree from the University of Colorado in 1939.He entered PHS in 1940, and served in the
Division of Pathology and as Scientific Director,Division of Research Grants, NIH, before being ap-pointed Chief of the Cancer Chemotherapy NationalService Center in 1955 . In 1958 he was appointedAssociate Director, NIH, and served in this capacityuntil appointed Director of NCI on July 1, 1960 .On November 10, 1969, he became Director of
the Bureau of Health Professions Education andManpower Training.
NOVEMBER 10, 1969 TO MAY 4, 1972
Carl Gwin Baker, M.D .Dr. Carl Gwin Baker was born in Louisville, Ky.,
November 27, 1920, and received his M.D. degreefrom the University of Louisville in 1944 and hisM.A . degree in biochemistry from the University ofCalifornia at Berkeley in 1949. He served as aMedical Officer in the U .S . Navy, 1945-1946 .He entered the PHS in 1949 and served in the
Laboratory of Biochemistry, the Research GrantsBranch, and the Office of the Director, NCI, until1958 when he was appointed Assistant Director,NCI . During 1957-1958 he was Assistant to theAssociate Director for Intramural Research, NIH.He became Associate Director for Program, NCI, in1961 after serving as Acting Scientific Director forIntramural Research . He was named ScientificDirector for Etiology, NCI, in 1967 . He became Act-ing Director of NCI November 10, 1969, and was_appointed Director of NCI July 13, 1970 .On May 5, 1972 he was named Special Assistant
to the Director, NIH, with responsibility to plan andestablish a new Office of Technology Im-plementation. Following his retirement from thePublic Health Service on September 1, 1972, hebecame President of Hazleton Laboratories, Inc ., ofFalls Church, Va .
Guy Rene Newell, M.D .
MAY 5, 1972 TO PRESENT
Frank Joseph Rauscher, Jr., Ph.D.Dr . Frank Joseph Rauscher, Jr. was born in
Hellertown, Pennsylvania, on May 24, 1931 . Hereceived his B.S . degree from Moravian College in1953 and his Ph.D. degree from Rutgers in 1957.Dr. Rauscher came to the National Cancer In-
stitute in 1959 and served as a microbiologist inthe Laboratory of Viral Oncology until 1964, whenhe was appointed Head, Viral Oncology Section . Heserved in this position until 1965, when he was
AUGUST 1, 1973 TO PRESENT
The new Deputy Director of the National CancerInstitute, Dr. Guy R. Newell, was born in Bogalusa,Louisiana, September 21, 1937 . Dr . Newellreceived both his B.S . (1959) and M.D . (1962)Degrees from Tulane University and his M.S . inHygiene from the Harvard School of Public Healthin 1968. From July 1963 to June 1965 he served asa Research Planning Associate in the Office of the
DIRECTORNATIONAL CANCER PROGRAMNATIONAL CANCER INSTITUTE
DEPUTY DIRECTORNATIONAL CANCER INSTITUTE
Director, NCI . Between July 1965 and June 1968 hereceived training in internal medicine and oncologyat the Johns Hopkins Hospital and the Peter BentBrigham Hospital . He returned to the NCI in July1968, where he was an Assistant for Program, ViralOncology and served as Executive Secretary,Biometry & Epidemiology Contract Review Com-mittee until June 1970. From July 1970 until hisappointment as Deputy Director, NCI in August1973, Dr. Newell held positions of Assistant andthen Associate Professor of Epidemiology at TulaneUniversity.
PRESIDENT'S CANCER PANEL
made Acting Chief, Viral Leukemia and LymphomaBranch . During this period, he also served as Chair-man, Special Virus Cancer Program . In 1966, hebecame Chief of the Viral Leukemia and LymphomaBranch until 1967 when he was appointedAssociate Scientific Director for Viral Oncology. Dr .Rauscher became Acting Scientific Director forEtiology in 1969, and was subsequently namedScientific D_ irector in 1970 .On May 5, 1972, President Nixon named him
Director of the National Cancer Institute and of theNational Cancer Program .
EXPIRATIONOF
APPOINTMENT
Mr . Benno C. Schmidt, Chairman 2-16-75J . H . Whitney & Co.New York City, New York
Dr. R . Lee Clark 2-20-77University of TexasM.D. Anderson Tumor ClinicHouston, Texas
Dr . Ray D . Owen 2-20-76California Technological InstitutePasadena, California
NATIONAL CANCER ADVISORY BOARD
Rockefeller University
Armed Forces Institute of PathologyNew York, New York
Washington, D.C .
APPOINTEESEXPIRATION
OFAPPOINTMENT
EXPIRATIONOF
APPOINTMENT
Dr. Jonathan E . Rhoads, Chairman 3-31-78 Dr . Phillippe Shubik 3-9-76University of Pennsylvania University of NebraskaPhiladelphia, Pennsylvania Omaha, Nebraska
Dr. Harold Amos 3-31-76 Dr . Howard E . Skipper 3-31-78Harvard Medical School Southern Research InstituteBoston, Massachusetts Birmingham, Alabama
Mr . Elmer H . Bobst 3-31-76 Dr . Sol Spiegelman 3-31-74Warner-Lambert Company Columbia UniversityNew York, New York New York, New York
Dr . Arnold L. BrownBrown 9-30-74 Dr. James D. Watson 3-31-74Mayo Clinic Cold Spring Harbor LaboratoryRochester, Minnesota Cold Spring Harbor, New York
Dr . Frank J . Dixon 3-31-78 Dr. W. Clarke Wescoe 3-31-78Scripps Clinic and Research Foundation Sterling Drug, Inc .La Jolla, California New York, New York
Mr . James S . Gilmore, Jr. 9-30-74Gilmore Broadcasting CorporationKalamazoo, Michigan EX-OFFICIO MEMBERS
Dr . John R. Hogness 3-31-78National Academy of SciencesWashington, D.C . Honorable Caspar W. Weinberger
Mr. Donald E. Johnson 3-31-76 Secretary, Department of Health, Education,and Welfare Washington, D.C.Advertisers Press, Inc .
Flint, Michigan Dr. Marc J . MusserMrs . Mary Lasker 3-31-74 Veterans Administration
Washington, D.C .Albert and Mary Lasker FoundationNew York, New York Dr. H . Guyford Stever
Dr. Irving M . London 3-31-76 Director, National Science FoundationHarvard-MIT Program in Health Sciences
Washington, D.C .
and Technology Dr. Robert S . StoneCambridge, Massachusetts Director, National Institutes of Health
Dr . Gerald P. Murphy 3-31-76 Bethesda, MarylandRoswell Park Memorial Institute Dr . Richard S . WilburBuffalo, New York Department of Defense
Dr . Gerald H . Ogura 3-31-74 Washington, D.C.Washington UniversitySt. Louis, Missouri
Mr. Laurance S. Rockefeller 3-31-78 ALTERNATESRockefeller Brothers FoundationNew York, New York
Dr . Harold P . Rusch 3-31-74 Dr . Lyndon E . Lee, Jr.University of Wisconsin Medical Center Veterans AdministrationMadison, Wisconsin Washington, D.C .
Dr . Frederick Seitz 3-31-74 Dr . D. Murray Angevine
NATIONAL CANCER INSTITUTE EXECUTIVE COMMITTEE
Dr . Guy R . Newell, ChairmanDeputy Director, NCI
Mr. Calvin B . Baldwin, Jr.Associate Director for Administrative Management
Dr . Nathaniel I . BerlinDirector, Division of Cancer Biology & Diagnosis
Mr . . Louis M . CarreseAssociate Director for Program Planning and Analysis
Dr. Diane J . FinkAssociate Director for Cancer Control
Mr. Frank Karel IIIAssociate Director for Cancer Communications
Dr . Alfred M. KetchamClinical Director, NCI
Dr . Bayard H . Morrison III,Assistant Director, NCI
Dr. Gregory T . O'ConorAssociate Director for International Affairs
Dr. James A. PetersDirector, Division of Cancer Cause and Prevention
Dr . J . Palmer SaundersDirector, Division of Cancer Research Resources and Centers
Dr. Richard A . TjalmaAssistant Director, NCI
Dr. Charles G . ZubrodDirector, Division of Cancer Treatment
Dr. Frank J . Rauscher, Jr ., Ex OfficioDirector, National Cancer Program, National Cancer Institute
NATIONAL CANCER INSTITUTE ORGANIZATION
DIRECTOR
NCIEXECUTIVECOMMITTEE
ASSOCIATE DIRECTOR ASSOCIATE DIRECTOR ASSOCIATE DIRECTOR ASSOCIATE DIRECTOR ASSOCIATE DIRECTORFOR FOR FOR FOR FORPROGRAM .PLANNING CANCER INTERNATIONAL CANCER ADMINISTRATIVEAND COMMUNICATIONS AFFAIRS CONTROL ° MANAGEMENTANALYSIS
DIRECTOR, DIVISION DIRECTOR, DIVISION DIRECTOR, DIVISION DIRECTOR, DIVISIONOF OF OF OF CANCER
CANCER CAUSE CANCER BIOLOGY CANCER RESEARCH RESOURCESAND AND TREATMENT AND
PREVENTION DIAGNOSIS CENTERS
DEPUTY DIRECTOR NATIONALPRESIDENT'SASSISTANT DIRECTORS CANCERCANCERCLINICAL DIRECTOR ADVISORYPANEL BOARD
8
MaNatan
stitute; evaluates resource needsfor the National Cancer Program ;develops and provides supportfor management and scientificinformation systems .
PROGRAM ANALYSIS ANDFORMULATION BRANCH
Dr. Abraham Cantarow (acting)
SYSTEMS PLANNINGBRANCH
Mr. John E Shulskis
MANAGEMENT &SCIENCEINFORMATION SYSTEMS
vacant
Plans, develops, directs, and coordinates the activities and programs of the Institute andof the National Cancer Program; and provides overall administrative guidance and services.
terprets program and organizes,prepares and disseminatesreports on cancer research forresearch institutions and otherorganizations participating in theNCP; maintains liaison with NCIconstituents on behalf of theDirector; responds to publicinquiries; prepares and coor-dinates internal reports fordissemination within the In-stitute, the Executive Branch,and the Congress ; and serves asa focal point for information onlegislation .
NATIONAL CANCER INSTITUTEDr. Frank 1. Rauscher, Jr ., DirectorDr. Guy R. Newell, Deputy Director
Develops a national program planfor Cancer Control in coor-dination with the Divisions of theNCI ; administers and managesthe cancer control program; andmaintains liaison with othergovernmental agencies and withprofessional and voluntaryorganizations which have cancercontrol-related activities or an in-terest in cancer control.
ASSOCIATE DIRECTORFOR
CANCER CONTROLDr . Diane J . Fink
ASSOCIATE DIRECTORFOR
INTERNATIONAL AFFAIRSDr . Gregory T, O'Conor
Plans, coordinates, and managescooperative international cancerresearch activities and providesleadership within the NationalCancer Institute for the develop-ment of international programsand activities.
ASSOCIATE DIRECTORFOR
ADMINISTRATIVE MANAGEMENTMr. Calvin B. Baldwin, Jr .
Directs, coordinates, and con-ducts administrative manage-ment activities of the Institute in-cluding: personnel, budget, con-tracts, and administrative ser-vices ; advises Director on ad-ministrative managementaspects of the program.
ASSOCIATE DIRECTORFOR PROGRAM
PLANNING AND ANALYSISMr. Louis M. Carrese
ASSOCIATE DIRECTORFOR
CANCER COMMUNICATIONSMr. Frank Karel III
nages development of the Develops and manages theional Cancer Program Plan ; program communications ac-lyzes programs of the In- tivities of the NCI/NCP ; in-
PROGRAM LIAISON PROGRAM MANAGEMENT CAUSE & PREVENTION ADMINISTRATIVE PERSONNEL MANAGEMENTBRANCH BRANCH BRANCH
ii
SERVICES BRANCH BRANCHMr. Robert G. Schonfeld Dr . George E. Jay, Jr. Dr. Robert L Woolridge Mr. Thomas L Kearns Mrs . Rosemary H . Williams
EDUCATION &TECHNICAL DETECTION & FINANCIAL MANAGEMENT RESEARCH CONTRACTSREPORTS BRANCH DIAGNOSIS BRANCH TREATMENT BRANCH BRANCH BRANCHMr . William S. Gray vacant
vacantMr. Earle L Browning Mr . Carl A . Fretts
REHABILITATION BRANCH EDUCATION &TRAINING BRANCH
Mr. Lawrence D . BurkeDr. Margaret H . Edwards
CANCER CAUSEAND PREVENTION
ADVISORY COMMITTEE
DIVISION OF CANCER CAUSE AND PREVENTIONDr. James A. Peters, Director
Dr . Gio B. God, Deputy Director (acting)
Plans and directs a program of laboratory, field and demographicresearch on the cause and natural history of cancer and meansfor preventing cancer through direct in-house research andthrough research contracts; evaluates mechanisms of cancer in-duction by viruses and by environmental carcinogenic hazards;serves as the focal point for the Federal Government on the syn-thesis of clinical, epidemiological, and experimental datarelating to the cause of cancer.
ASSOCIATE ÍDIRECTOR FORPROGRAM
Plans, implements, and administers a coordinated programof basic and applied research on carcinogenesis bychemical and physical factors and on its prevention; con-ducts programs in the areas of: (a) coordination on en-vironmental carcinogenesis; (b) epidemiologic pathology;and (c) registry of experimental tumors.
BIOLOGY BRANCHDr. Herbert 1. Rapp
SCIENTIFIC COORDINATORFREDERICK CANCER RESEARCH
CENTERDr. William W. Payne
VIRAL LEUKEMIA ANDLYMPHOMA BRANCHDr. George 1. Todaro
Analyzes cause and prevention research activitiesof the Institute and participates in the planning ofa coordinated cause and prevention researchprogram ; plans, analyzes, and coordinates theprogram of the Division; and provides leadershipfor and coordinates Division scientific andtechnical information activities.
ASSOCIATE DIRECTORFOR CLINICAL RESEARCH
Dr. Alfred S. Ketcham
Plans and directs the clinicalprograms of the Division .
Dr . Marvin A. Lutzner
SURGERYBRANCH
Dr.
DERMATOLOGYBRANCH
Alfred S. Ketcham
METABOLISMBRANCH
Dr. Thomas A . Waldmann
LABORATORY OFPATHOLOGY
Dr. Louis B. Thomas
RBRANCH
Dr . Ralph E:Johnson
DIVISION OF CANCER BIOLOGY AND DIAGNOSISDr . Nathaniel 1 . Berlin, Director
Plans and directs the Institute's general laboratoryand clinical research activities ; plans and managescollaborative programs in immunology, diagnosisand breast cancer ; and serves as the national focalpoint for programs to improve the detection anddiagnosis of human cancers .
LABORATORY OFPHYSIOLOGY
Dr. Nathaniel I. Berlin(acting)
LABORATORY OFPATHOPHYSIOLOGYDr. P. M.
Gullino(acting)
ASSOCIATE DIRECTORFOR IMMUNOLOGYDr. William D. Terry
(acting)
Plans, directs and evaluates a programof both intramural and contactresearch in tumor immunology.
LABORATORY OF- . CELL BIOLOGYDr. Lloyd W. Law
LABORATORY OFBIOCHEMISTRY
LABORATORY OFMOLECULAR BIOLOGY
Dr . Ira H. Pastan
BOARD OFSCIENTIFICCOUNSELORS
ASSOCIATE DIRECTORFOR PROGRAM PLANNING
Dr. Irvin C . Plough
Analyzes research programs of theDivision and participates in researchplanning and evaluation, and in theestablishment of priorities in terms ofpublic need and probability of success ;maintains management informationfiles on all research projects ; andmonitors the professional aspects ofresearch contract management.
PLANNING ANDANALYSIS BRANCH
Dr. Ihor 1. Masnyk
DIAGNOSISBRANCH
Dr. William Pomerance
BREAST CANCERPROGRAM
COORDINATINGBRANCH
Dr. Erwin P. Vollmer
ASSOCIATE DIRECTORFOR CANCER THERAPY
EVALUATION
Dr. Stephen K. Carter
Plans and directs the clinical con-tract program, testing combinedmodality therapy approaches andthe clinical testing of in-vestigational new agents; anddirects the evaluation of the ef-fectiveness of specific types andmethods of cancer therapy.
CANCER TREATMENTADVISORY COMMITTEE
ASSOCIATE DIRECTORFOR MEDICAL ONCOLOGY
Dr. Paul P. Carbone
Plans and directs the clinicalresearch aspects of the programs ofthe Division .
DIVISION OF CANCER TREATMENTDr. C . Gordon Zubrod, Director
Dr . Seymour M. Perry, Deputy Director
Plans, directs and coordinates an integratedprogram of cancer treatment activities withthe objective of curing or controlling cancerin man by utilizing combination modalitiesincluding chemical, surgical, radiologicaland certain immunological techniques ; ad-ministers a total drug development program;and serves as the national focal point for in-formation and data on cancer treatmentstudies.
ASSOCIATE DIRECTORFOR
EXPERIMENTAL THERAPEUTICSDr. Vincent T. Oliverio
Plans and directs studies con-cerning the pharmacologic andtoxicologic aspects of cancerchemotherapy including studies onthe growth characteristics of nor-mal and malignant cells and the ef-fects of chemotherapeutic agentson these cells .
J 4
ASSOCIATE DIRECTORFOR DRUG RESEARCH &
DEVELOPMENT
DRUG DEVELOPMENTBRANCH
Dr. Harry B. Wood,Jr.
DRUG EVALUATIONBRANCH
Dr. John M. Venditti
LABORATORY OFEXPERIMENTALCHEMOTHERAPY
ASSOCIATE DIRECTORFOR PROGRAM
Dr. Seymour M. Perry
Analyzes treatment activities of the Institute ;participates in planning of treatment program;and evaluates areas of cancer treatment withgreatest need for study.
ASSOCIATE DIRECTORFOR BALTIMORE CANCER
RESEARCH CENTER
LABORATORYOF PHARMACOLOGYDr. Carl Levy (acting)
CLINICAL BRANCH
Dr. Michael D. Walker
LABORATORY OF CHEMICALPHARMACOLOGY
Dr . Richard A. Adamson (acting)
LABORATORY OF TOXICOLOGYDr. Anthony M. Guarino
(acting)
LABORATORY OF MOLECULARPHARMACOLOGYDr. Kurt W. Kohn
LABORATORY OF TUMOR CELLr BIOLOGYDr. Robert C. Gallo
INVESTIGATIONAL MEDICINE BRANCHDRUG BRANCH Dr. Vincent T. DevitaDr. Milan Slavik (acting)
COMBINED MODALITY PEDIATRIC ONCOLOGYBRANCH
i
BRANCHDr. Stephen K. Carter (acting) Dr. John L Ziegler
NCI-VA MEDICALONCOLOGY BRANCHDr. Oleg S. Selawry
Dr . Saul A. Schepartz
Plans and directs the first, or drugdevelopment and evaluation phase,of the cancer chemotherapyprogram, primarily conducted
Dr. Michael D. Walker
Conducts an integrated program oflaboratory and clinical research onthe therapy and management ofcancer patients, including phar-
through research contracts and in- macologic investigations of thecluding technical information ser- mechanisms of action of anti-vices to DR&D and other cancer drugs.collaborative programs .
Plans and directs NCI grant-supported activities, and recom-mends Institute policies relating tothe administration of biomedicaland clinical research grantprograms ; develops, reviews andcoordinates plans and criteria forthe implementation of NCI grant-supported research programs andevaluates effectiveness of these ac-tivities in achieving the Institute'smissions ; and advises the Directorof the Division, the National Can-cer Advisory Board, and other ad-visory bodies of grant activitiesand developments.
DIVISION OF CANCER RESEARCH RESOURCES AND CENTERSDr. J. Palmer Saunders, Director
Dr . William A. Walter, Deputy Director
Plans and directs the Institute's grant-supported activities ; recommends Institutepolicies relating to the administration of grant programs ; develops, reviews and coor-dinates plans and criteria for the implementation of NCI grants and evaluates ef-fectiveness of grant-supported activities in achieving the Institute's missions ; andadvises the Institute Director, the National Cancer Advisory Board, and other ad-visory bodies of grant activities and developments.
Plans and directs the Cancer Cen-ters Program, the ResearchFacilities Construction Program,and the Cancer Clinical EducationProgram ; supplies data to reviewcommittees and the National Can-'cer Advisory Board ; evaluates theneed for and effectiveness of theseprograms ; interprets programs togrant applicants, grantees, univer-sities and research institutions ;and advises the Director of theDivision, the National Cancer Ad-visory Board and other advisorybodies of grants activities anddevelopments .
Serves as the Division focus forprogram planning and evaluationactivities including development ofprogram objectives, alternatives,and policy positions ; stimulates andguides divisional planning ac-tivities, addresses program ac-complishments, and overseesanalytical and reporting functions ;applies management sciencetechniques including systemsanalysis and design, operationsresearch, and other analytical ap-proaches to Division programs ; andmaintains liaison with the Office ofProgram Planning, Office of theDirector, NCI .
GRANTS ADMINISTRATIONBRANCH
Mr. Leo F. Buscher, N .
BIOMEDICAL RESEARCH CANCER CENTERS BRANCHPROGRAMS BRANCH Dr. John W. Yarbro PROGRAM ANALYSIS AND
Dr. Thaddeus J. Domanski (acting) . EVALUATION BRANCHMr . Harry Y. Canter
CLINICAL INVESTIGATIONS RESEARCH FACILITIESBRANCH CONSTRUCTION BRANCH PROGRAM DEVELOPMENT AND
Dr . William G . Hammond Dr . Donald G . Fox OPERATIONS BRANCHDr. John T. Kalberer, 1r. (acting)
NATIONAL ORGAN SITE CANCER CLINICALPROGRAMS BRANCH
y
EDUCATION BRANCHDr. Samuel Price Dr. William L Ross (acting)
1ASSOCIATE DIRECTOR ASSOCIATE DIRECTOR ASSOCIATE DIRECTOR REVIEW AND
FOR RESEARCH PROGRAMS FOR CANCER CENTERS FOR PROGRAM PLANNING REFERRAL BRANCHDr. Thomas 1. King (acting) Dr. John W . Yarbro (acting) Dr. John T. Kalberer, Jr. (acting) Dr . Mordecai H. Gordon
270
EYE RESEARCHFOUNDATION
2,141 Square Feet6 Personnel
BUILDING 10CLINICAL CENTER84,190 Square Feet
394 Personnel
BUILDING 37117,687 Square Feet
542 Personnel
BUILDING LOCATION ANDSQUARE FOOTAGE OCCUPIEDBY FULL-TIME PERMANENTPERSONNEL IN BETHESDA,MARYLAND AREAAS OF JUNE 30, 1973
TOTALApproximatety 426,661 Square Feet
1,736 Personnel*
WESTWOOD BUILDING25,890 Square Feet
152 Personnel
Route 70S
Route 495 (Capital Beltway)
Cedar Lane
Old Georgetown Road
BUILDING 351,956 Square Feet
2 Personnel
BUILDING 146,804 Square Feet
4 Personnel
Bradley
LITTON BIONETICS BUILDING1,180 Square Feet
18 Personnel
ASZ
OZ
Nicholson Lane
BUILDING 3134,065 Square Feet
210 Personnel
BUILDING 812,243 Square Feet
38 Personnel
BUILDING 4133,973 Square Feet
94 Personnel
LANDOW BUILDING37,843 Square Feet
195 Personnel
13
CANCER STATISTICS
Cancer Incidence
More than 53 million Americans now living willeventually have cancer - according to presentrates - about one in four persons. Over the years,cancer will strike in 2 out of 3 American families .In 1974, there will be an estimated 655,000 newcancer cases diagnosed. (This does not includesuperficial skin cancer or carcinoma-in-situ of theuterine cervix, which have been included in prioryear statistics.)
Changes in the Incidence of Cancer'
The trend in cancer incidence based on the 1937,1947, and 1969 surveys is depicted in the figuresthat follow . For the white population, comparison ismade with trend data from the state of Connecticut,which has been collecting continuous data on theincidence of cancer since 19352. For both the whiteand black populations, the trend in cancer in-cidence is compared with the trend in cancer mor-tality as reported by the National Center for HealthStatistics .There is a marked difference in trend for males
and females. Among males, incidence of and mor-tality from cancer has been increasingly con-tinuously. The increase has been particularly largeamong blacks . In part, the reported increase amongblack men may reflect improvement in the deliveryof medical care resulting in more completediagnosis of the disease. However, it is likely that asubstantial fraction of the reported increasereflects the impact of environmental factors, e.g.,movement from rural to urban areas and con-centration in inner cities, changes in occupation,
'Source: "Report on the Third National Cancer Survey", Seventh NationalCancer Conference Proceedings.2Cancer in Connecticut, 1935-62 Connecticut State Department of Health ;Hartford, Connecticut, 1966 . More recent data have been provided by Dr.Barbara Christine, Director, Connecticut Tumor Registry.
1 4
and changes in eating, drinking, and smoking prac-tices.For females of both races, the available data in-
dicate that the incidence of cancer is eitherdecreasing (survey data) or leveling off (Con-necticut data). Among white women, mortality fromcancer has been decreasing; among black womenthe mortality rate has remained at the same levelsince 1950 .
Third National Cancer Survey
The National Cancer Institute is in the final processof completing the Third National Cancer Survey, aproject designed to provide incidence andprevalence data for the three-year period 1969-1971 for seven metropolitan areas and two states .Cancer is not a reportable disease in most of theUnited States and it has been over twenty yearssince a previous incidence study was undertaken .Two earlier studies on cancer incidence, in 1937and 1947-48 covered ten large metropolitan areas.A survey in Iowa in 1950 helped provide knowledgeof cancer incidence in rural areas. The field work ofthe current study is completed and the analysis isin process.
Information was gathered from all hospitals,clinics, laboratories, vital statistics offices andphysicians in each survey area concerning patientswith active cancer during the years 1969, 1970 and1971 . A preliminary report on cancer incidencerates for 1969 was issued in 1971 and the reportfor all three years will be published during 1974.Data will be given by sites and histologic types ofcancer by sex, race, age and geographic areas.Supplementary information has been collected
on a ten percent sample of patients, regarding ex-tent of disease, treatment, cost of medical care andeconomic impact on the family . As the analysisproceeds, reports will be issued .
2O
000óo .
400
300
200
WP 400WFQ6
300
200
100
WHITEMALES
ALL SITESa-~ U.S . INCIDENCE
--c CONNECTICUT INCIDENCEo----o U.S. MORTALITYo----o CONNECTICUT MORTALITY
OTIQ
a
ALL SITES
*All sites : trend of cancer incidence and mortality rates, 1935-1969 (age-adjusted, 1950 standard population). Note : In order tomake the current figures comparable with the earlier data, leukemia, Hodgkin's disease, skin cancer and carcinoma in situ of theuterine cervix were excluded.
MORTALITY FOR THE FIVE LEADING CANCERSITES BY AGE GROUP AND SEX - 1970
*Includes Brain and Central Nervous System
Source : National Center for Health Statistics, 1970**Includes Lymphosarcoma and other Lymphomas
1 5
TOTAL UNDER15 15 - 34 35 - 54 55 - 74 75 & OVER
MALE FEMALE MALE FEMALE MALE FEMALE MALE FEMALE MALE FEMALE MALE FEMALE
Lung Breast Leukemia Leukemia Leukemia Breast Lung Breast Lung Breast ProstateColon &Rectum
52,801 29,652 933 739 692 517 9,361 8,750 34,121 14,167 9,510 9,610
Colon & Colon & Brain* Brain* Hodgkin's Leukemia Colon & Lung Colon & Colon & Lung Breast_Rectum Rectum Disease Rectum Rectum Rectum
22,142 23,838 509 371 488 507 2,421 3,246 11,650 1,523 9,110 6,213
Prostate Lung Lympho-** Bone Brain* Uterus Pancreas Uterus Prostate Lung Colon & Stomachsarcoma Rectum
17,252 12,367 138 91 386 346 1,416 3,120 7,423 6,617 7,576 2,744
Pancreas Uterus Bone Kidney TestisHodgkin's rain* Colon & Pancreas Uterus Stomach PancreasDisease Rectum
10,063 12,060 79 65 411 321 1,334 2,559 5,594 5,903 3,234 2,925
Stomach Ovary Kidney Lympho-** Lympho-** Brain* Stomach Ovary Stomach Ovary Pancreas Uterussarcoma sarcoma
9,805 9,958 71 55 247 286 1,221 2,538 5,288 5,398 2,709 2,687
400U.S. INCIDENCE
- - U.S. MORTALITY
WHITE FEMALES --a CONNECTICUT INCIDENCEr---o CONNECTICUT MORTALITY300
200
100
RELATIONSHIP OF CANCER TO LEADING CAUSESOF DEATH IN THE UNITED STATES
1970
Source: National Center for Health Statistics, 1970Cause of death classified by the Eighth Revision, International Classification of Diseases, Adapted, 1965
RANK CAUSE OF DEATHNUMBER
OFDEATHS
DEATH RATEPER
100,000POPULATION
PERCENTOF
TOTALDEATHS
All Causes 1,921,031 945.3 100.0
1 Diseases of heart 735,542 362.0 . 38.3
2 Cancer 330,730 162.8 17.2
3 Cerebrovascular diseases 207,166 101 .9 10.8
4 Accidents 114,638 56.4 5.9
Motor vehicle accidents (54,633) (26.9) (2 .8)
All other accidents (60,005) (29.5) (3.1)
5 Influenza and pneumonia 62,739 30.9 3.3
6 Certain causes of mortality in early infancy 43,205 21 .3 2.2
7 Diabetes mellitus 38,324 18.9 2.0
8 Arteriosclerosis 31,682 15.6 1 .6
9 Cirrhosis of liver 31,399 15.5 1.6
10 Bronchitis, emphysema, and asthma 30,889 15.2 1.6
11 Suicide 23,480 11 .6 1 .2
12 Homicide 16,848 8.3 0.9
13 Congenital anomalies 16,824 8.3 0.9
14 Nephritis and nephrosis' 8,877 4.4 0.5
15 Peptic ulcer 8,607 4.2 0.5
All other cases 220,081 108.0 11 .5
ESTIMATED CANCER DEATHS AND NEW CASES BY SEX AND SITE -- 1974
Note: The estimates of new cancer cases are offered as a rough guide and should not be regarded as definitive. Especially note that year to yearchanges may only represent improvements in the basic data .
*Carcinoma-in-situ of the uterine cervix and superficial skin cancers not included in totals.(Reprinted with permission from Cancer Facts and Figures, American Cancer Society, 1974, from data supplied by the National Cancer Institute.)
1 7
ESTIMATED DEATHSTOTAL MALE FEMALE355,000 193,000 162,000
7,900 5,700 2,200225 200 25
1,800 1,300 500650 400 250'l525 400 450125
1,250 8003,450 2,600 850
100,100 53,100 47,0006,300 4,600 1,700
14,300 8,400 5,900650 300 _350
37,300 17,300 20,00010J00 6,090 4,7009,800 4,800 5,00019,400 10,900 8,5001,650 800 850
79,900 63,500 16,4003,200 2,800 400
75,400 59,900 15,5001,300 _8-00 500
8,700 5,000 3,7001,900 1,100 8001,700 900, 8005,100 1,000 _ ?1100
32,750 250 32,500
41,800 19,000 22,8007,800 - 7,800¡3,400 _ 3,40010,700 -
_10,700
900 - 90018,000 18,000 -1,000 1,000 -
16,200 10,700 5,5009,200 6,300 2,9007,000 4,400 2,600
350 150 200
8,100 4,700 3,400
1,650 650 1,0001,150 350 800500 300 200
15,300 8,600 6,700
220,400 11,290 9,2007,700 4,100 3,6003,700 2,200 1,5004,600 2,400 2,2004,400 2,500 1,900
21,850 10,450 11,400
SITEAll Sites*Buccal Cavity & Pharynx (Oral)LipTongueSalivary GlandFloor of MouthOther & Unspecified MouthPharynx
Digestive OrgansEsophagusStomachSmall IntestineLarge Intestine (Colon-Rectum)
LiverPancreasOther & Unspecified Digestive
Respiratory SystemLarynxLungOther & Unspecified Respiratory
Bone, Tissue and SkinBoneConnective TissueSkin (Melanoma)*
Breast
Genital OrgansCervix, Invasive* UterusCorpus UteriOvaryOther Female GenitalProstateOther Male Genital
Urinary OrgansBladderKidney & Other Urinary
Eye
Brain & Central Nervous System
Endocrine GlandsThyroidOther Endocrine
Leukemia
LymphomasLymphosarcoma & ReticulosarcomaHodgkin's DiseaseMultiple MyelomaOther Lymphomas,
All Other & Unspecified Sites
_ESTIMATED NEW CASESTOTAL MALE FEMALE
655,000 326,000 329,00023,700 16,700' 7,000
,700 3,300 4004,800 3,400 1,400
8,500 5,100 3,400
6,700 4,900 1,800
166,900 86,800 80,1007,400 5,500 1,900
23,100 14,000 9,1002,200 1,200 1,00068,000
_31,000 : : 37,000
31,000 17,000! 14,00011,400 5,600 ; 5,80020,300 11,000 9,3003,500 1,500_ 2,000
95,200 77,000 18,2009,500 8,300' 1,200,
j 83,000_67,000' 16,000
2,700 1,700- 1,000
14,700 7,800 7,4002',000 1,100 9004500206r
2,400_3,800
2,10'O' 4,400
89,700 700! 89,000;
125 800 58,100 67,70019,000' - 19,00027,000' - 27,00017,000 - 17,0004,700 - 4,700
54,000 54,000 -4,100 4,100 -42'28:400
900 30,00021,000
12,9007,400
14,500 9,000 5,500
1,700 800 900
10,700 5,900 4,800
8,900 2,600 6,3007,800 2,100 5,7001,100 500 600
21,200 12,000 9,200
27,600 15,100 12,5009,900 5,400 4,5006,900 4,100 2,8007,500 3,800 3,700
3,300 1,800 1,500
26,000 13,000 13,000
NATIONAL CANCER PROGRAM STRATEGY HIERARCHY
THE NATIONALCANCER PROGRAM (NCP) STRATEGY IS THE COM-BINATION OF SELECTED LABORATORY, FIELD AND CLINICALRESEARCH AND CONTROL COURSES OF ACTION NECESSARY TOACHIEVE THE PROGRAM OBJECTIVES AND GOAL.
o TO FACILITATE PLANNING AND IMPLEMENTATION OF THE PRO-GRAM STRATEGY, IT HAS BEEN ORGANIZED IN A HIERARCHICALFORMAT WITH THE FOLLOWING LEVELS :
- NATIONAL CANCER PROGRAM GOAL- RESEARCH THRUSTS AND CONTROL INTERVENTIONS- RESEARCH AND CONTROL OBJECTIVES- RESEARCH AND CONTROL APPROACHES- RESEARCH AND CONTROL APPROACH ELEMENTS- RESEARCH AND CONTROL PROJECT AREAS
THE HIERARCHICAL STRUCTURE PROVIDES CONTINUING FOCUSON CONSTANT, DISEASE-ORIENTED OBJECTIVES.
THE FIRST THREE LEVELS OF THE HIERARCHY ARE PRESENTEDON THE FIGURE .
- THE TOP LEVEL (CENTER OF THE CIRCLE) IS THE NATIONALPROGRAM GOAL.
- THE SECOND LEVEL INCLUDES THE NCP RESEARCH THRUSTSAND CONTROL INTERVENTIONS .
- THE THIRD LEVEL INCLUDES THE NCP RESEARCH AND CON-TROL OBJECTIVES.
- THE NEXT THREE LEVELS-APPROACHES, APPROACH ELEMENTSAND PROJECT AREAS-PROVIDE INCREASINGLY MORE DETAIL-ED DEFINITION OF THE SCIENCE AND ACTIVITIES ENCOMPASS-ED WITHIN EACH RESEARCH AND CONTROL OBJECTIVE .
MIN \ISSEMINN1 DISSE ED CANCER318 b 8 O
7 / AND U ECAVAIIVE 31 0NV SO QUES ARE A Nl CARE
SUPPORTIVETIVE PALLATOPTIMAL lVHl ASSURE
PATIENTSCANCER d0 NOIIVL
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11
NATIONAL RESOURCES FOR CANCER RESEARCH - FISCAL YEAR 1973
32p,700,000 (4OURCES $320,
' SO
STATE AND LOCALGOVERNMENTS$96,200,0000Z8%)
OTHERFEDERALAGENCIES$90,200,000
VOLUNTARYAGENCIES$95,400,000
$21,800,STI$21,
%)
Y (2.2TRO ,100,
NATIONAL CANCER INSTITUTE$431,245,000
(57.4%)
245,0431,
NA L CANCER I _Add
57. 4%
O90
1200
SOURCE : Analysis of Mid-Range Resources Requirements for the National Cancer Program, March 1973, with adjustment for cost-of-living increases .
20
TOTAL: $751,945,000
tom
NCI BUDGET ADMINISTRATION PROCESS - UNDER CANCER ACT OF 1'971
2NOTE:SIMULTANEOUS ACTIVITIES BY MORE THAN ONEORGANIZATION INDICATE COOPERATIVE EFFORTS
LEGEND : o OPERATION . REVIEW & DECISION
BUDGET PHASE PRELIMINARY PLANNING PRESIDENT'S ACQUISITION OF APPORTIONMENT(CALENDAR FORMAL ESTIMATE TO OMB BUDGET APPROPRIATION & EXECUTION
TIME), t" AND ESTIMATE
(JULY-JUNE)(JANUARY-JULY) (AUGUST-DECEMBER) (JANUARY) ,(JANUARY-JUNE)ORGANIZATIONREVIEW NATIONAL REVIEW
NCI CANCER PROGRAMPLAN-UPDATE GOALS,ESTIMATES'AND DEVELOP
PARTICIPATEIN BUDGET PREPARE NCI PORTION OF
PREPARE CONGRESSIONAL ISSUE ALLOW-PRIORITIES,PRIORITIES, ETC. PRELIMINARY PREPARE FORMAL HEARINGS PRESIDENT'S BUDGET JUSTIFICATION ( REQUEST QUARTERLY
I ANC TO PRO-MS- BUDGET OMB SUBMISSION PARTICIPATEIN
APPORTIONMENT Of GRAMS
AND STAFF _ APPROPRIATIONSFUNDS
DIVISIONS HEARINGSDEVELOPESTIMATES
NATIONALCANCER
COMMENT ONADVISORY PRELIM(- REVIEW
BOARDNARY BUDGET AND COM-
MENT ONOMB SUB-MISSION
I PARTICIPATE" '
INS=
NIHREVIEW ANDCOM-MENT0OMB SUB- ' 'MISS( ON
SUBMITCONGRESSIONAL. ,D JUSTIFICATIONTO O
R FORPRE.,.
DHEW A PARTICIPATE IN0 APPROPRIATIONSMI HEARINGS
RECOMMEND FINALIZEREVIEW NCI ALLOWANCES PRESIDENT'S
-BUDGET BUDGET QUARTERLYOMB DOCUMENT APPORTIONMENT
.SET NCI REQUESTESTIMATESAPPORTIONMENTCONDUCT ALLOWANCE FROM NCI OF FUNDSBUDGET AND ADVISEHEARINGS NCI
SIGN LABOR-DHEWPRESIDENT ALLOWANCE PREPARE BILL IATIONSREVIEW BUDGET 'TRANSMIT I . INTO LAW
RECOMMENDATIONS MESSAGE BUDGET TOAND MAKE BUDGET TO CONGRESS CONGRESSDECISIONS
APPROPRIATIONS TRANSMIT LABOR-DHEWCONGRESS ACTION PASS FINAL BILLTO PRESIDENT APPROPRIATIONS
'LABOR DEWAPPROPRIATIONS BILL
ILLINOIS OHIO~-
INDIANA 44 $1,933,670$4,045,508 © $3,668,099
©$4,,0 0$1,170,451©$1,316,000
979 m30
J KENTUCKY
9
$443,541$259,782 VIRGINIAEE
1
WYORKNE
339 $44,857,324"m$11,699,000
0
®$23,142,703'$13,975,00076
DISTRIBUTION OF GRANT AND CONTRACT DOLLARS -- FISCAL YEAR 1973
SYMBOL KEY11 TOTAL NO. OF GRANTS & DOLLARS PER STATE
TOTAL NO. OF CONTRACTS & DOLLARS PER STATE
12 $3,077,66817 $4,979,000
FL PO IDA
© $173,355© $46,225PUERTO RICO
s
, 0$365,773© $179,857
'© $1,364,478-13$10,411,000
NORTH CAROLINA c
SOUTHCAROLINA
0$298,5141 $55,000
()$3,639,731©;$2,321,000
10$375,784I© $131,510,
I©$1,459,1421 $39,450`OD$5,373,279
$618,999
24 $1,328,476M$4,809,000
51 $11,103,105$30,32%00069
DISTRICT OF COLUMBIA
26 $6,550,429M($4,726,000
FOREIGN RESEARCH GRANTS ANDCONTRACTS - FISCAL YEAR 1973 , (THOUSANDS OF DOLLARS)
COUNTRY NUMBER OF'GRANTSNUMBER OFCONTRACTS
TOTALAMOUNT
PERCENT OFTOTAL AMOUNT
AWARDED
Australia 1 2 $: 291 6.3,
Austria - 1 22 .5
Belgium 1 1 40 .9
Canada 4 4 293 6.3
Colombia, S.A. - 2 104 2.2
England 2 3 245 5.2
France 1 2 747 16.0
Germany - 1 57 1 .2
Israel 1 11 1,332 28.6
Italy 1 5 334 7.2Japan - 3 224 4.8
Netherlands - 3 252 5.4
Portugal 1 - 35 .7
South Africa - 1 36 .8
Sweden 2 7 469 10.0
Switzerland 2 77 1.7
Uganda - 2 101 2.2
TOTALS 16 48 $4,659* 100.0
ANNUAL APPROPRIATIONS - 1938-1974
24 .
1938 . . . . . . . . . . . $
400,0001939 . . . . . . . . . . . 400,0001940 . . . . . . . . . . . 570,0001941 . . . . . . . ., . . 570,0001942 . . .,,, . . . . . 565,0001943.,, . . . . . . . . 534,8701944 . ., . . .,, ., . 530,0001945,, . . . . . . . ., 561,0001946.., . ., .,,,, 548,7001947 . .,,,,,, ., . 1,820,9001948,..,,, .,,, . 14,500,000 15 .1949, ., ., . ., . ., 22,000,000
41,$574,841,220
1950 .,, . . . . . . ., 24,900,0001951 . . ., . .,, . . . 20,086,0001952 ., ., . ., . . . . 19,656,7501953 . . . ., . . ., ., 17,887,0001954 .. . . . . . . . ., 20,237,0001955 . . . . . . . . . . . 21,737,0001956 ...,, . . . . . . 24,978,0001957 .. . . . . . . . . . 48,432,0001958. . . . . . . . . . . 56,402,0001959 .. . . . . . ., . . 75,268,0001960 . .. . . . . . . . . 91,257,0001961 . . . . . . . . . . . 111,000,0001962 . .. . . . . . . . . 142,836,0001963 . .. . . . . . . . .
155,742,0001964 . . . . . . . . . . .
144,340,0001965 . . . . . . . . . . . 150,011,000 46.3%1966 . . . . . . . . . . .
163,768,000 \ $1,721,727,563
1967 ........... 175,656,0001968. . . . . . . . . . . 183,356,0001969 . . . . . . . . . . . 185,149,5001970 . . . . . . . . . . . 190,486,0631971 . . . . . . . . . . . 230,383,000
38.2% lá IL 1972 ...........378,794,000$1,422,190,500 AX \ 1973 �����492,205,000
1974. . . . . . . . . . 551,191,500
TOTAL $3,718,759,283
NCI PROGRAM STRUCTURE -- FISCAL YEAR 1974
(THOUSANDS OF DOLLARS)
TOTAL DOLLARS$589,155(estimate)
CO
NT C'>
Ó ERR
CAUSE &PREVENTIONRESEARCH$145,986(24.8%)
CANCER CONTROL$34,599(5.9%)
CONSTRUCTION$45,340(7.7%)
SEA ,010
RE $24,
ó4O
ell
DETECTION
DIAGNOSISRESEARCH$39,275(&7%)
CANCERBIOLOGY$88,678(14.5%)
TREATMENTRESEARCH$194,689(33.01/6)
,90
DEVEL
RESEAR
s 628
000 %
*Includes research that cannot reasonably be classified in any one of the other research thrusts, but where output has potential application to all thrusts.**Planning and core support of centers .
25
OBLIGATIONS BY BUDGET ACTIVITY
RESEARCH
RESOURCE DEVELOPMENT
CANCER CONTROL
(THOUSANDS OF DOLLARS)
Cancer Control . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ., . . . ., . . . .
5,512
34,599
45,814
Total NCI
$ 431,245
$ 589,155
$ 600,000
*Includes research that cannot reasonably by classified in any one of the other research thrusts, but where output has potential application to all thrusts .
NOTE : These distributions include a proportionate share of NCI Management and NIH Management Fund .
26
Cause and Prevention . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $ 116,234 $ 145,986 $ 151,662Detection and Diagnosis ., . . . . . ., . ., ., . . . ., . . . ., 27,135 39,275 41,744Treatment. . . . . .. . . . ., ., ., . . . . . . . ., ., . ., ., ., . ., ., ., . ., . . . ., ., . 147,025 194,689 203,128Cancer Biology* . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 66,216 85,678 89,321
Total Research 356,610 465,628 485,855
Cancer Center Support . . ., ., . . ., . . . ., . . . ., . . . . . ., 15,840 19,578 23,484Research Manpower Development ., ., ., 14,132 24,010 22,530Construction . . . . . . . ., ., ., . . . ., ., . . . ., ., ., . ., ., . . . ., . . . ., ., . 39,151 45,340 22,317
Total Resource Development 69,123 88,928 68,331
1973 1974 1975BUDGET ACTIVITIES ACTUAL ESTIMATE ESTIMATE
NATIONAL CANCER INSTITUTE1974 BUDGET BY ORGANIZATION
(THOUSANDS OF DOLLARS)
$283,558
$40,524
$75,779
$111,980
$77,314
PERCENT
DIVISION OF CANCER TREATMENT
DIVISION OF CANCER CAUSE AND PREVENTION
OFFICE OF THE DIRECTOR
*Includes $2,990,000 carry forward of Fiscal Year 1973/1974 funds.
$ 1,536 Supporting Services .315,650 Program Direction 2.616,940 Management Fund 2.99,133 Direct Construction 1,5
34,055 Cancer Control 5.8
$589,155* TOTAL 100.0
AMOUNT ACTIVITY OFTOTAL
DIVISION OF CANCER RESEARCH RESOURCES AND CENTERS
$115,153 Regular Program 19.5776 General Research Support ,1
91,155 Cancer Research Centers 15,510,503 Task Forces 1,823,643 Fellowship and Training 4,02,099 Research Career Programs .4
35,900 Construction 6.14,329 Review and Approval .7
DIVISION OF CANCER' BIOLOGY AND DIAGNOSIS
$ 32,153 Laboratory and Clinical Research 5.58,371 Task Forces 1.4
66,493 Virus Cancer Program 10,335,850 Carcinogenesis 6.110,722 Demography 1.84,915 Task Forces ,8
CANCER CONTROL OBLIGATIONS
PREVENTION$901,000
DIAGNOSISAND
TREATMENT$1,505,000
EARLYDETECTION$3,106,000
Fiscal Year 1973$5,512,000
Fiscal Year 1974$34,599,000(estimate)
TASK FORCE OBLIGATIONS - 1966 -1974
SRQJO0OSGZQSOT
26,000
24,000
22,000
20,000
18,000
16,000
14,000
12,000
10,000
8,000
6,000
4,000
2,000
BREAST CANCER TASK FORCE
LUNG CANCER TASK FORCE
BLADDER CANCER TASK FORCE
LARGE BOWEL CANCER TASK FORCE
PROSTATE CANCER TASK FORCE
1966 1967 1968 1969 1970 1971 1972 1973 1974FISCAL YEAR
(est.)
29
REIMBURSEMENT TO NIH MANAGEMENT FUNDFISCAL'' YEAR 1974
4.6 43.6%
$778,000
$65,942,000TOTAL NIH SERVICES
DISTRIBUTION OF NCI SERVICES$16,975,000
30
21 .0 14.8% 6 .6
$2,509,000
9.4 $1,594,000
$1,122,000
CLINICAL CENTER
Service FunctionsSocial WorkProfessional Services
Consultative ServicesAdmissions and Follow-upAnesthesiologyDiagnostic X-RayClinical PathologyBlood BankRehabilitation ServicePharmacy ServiceMedical RecordsTV Engineering
Nursing ServicePatient Nutrition ServiceEnvironmental Sanitation
ControlLaundryRadiation Safety
OFFICE OF ENGINEERING SERVICES
Research Facilities PlanningPlant Engineering ServicesLiaison & Inspection of Projects
DIVISION OF RESEARCH GRANTS
Initial Scientific Review ofApplications
Assignment of Research GrantApplications Among Institutes
DIVISION OF RESEARCH SERVICES
Laboratory AidsAnimal Hospital
DIVISION OF COMPUTER RESEARCH OFFICE OF ADMINISTRATIVE SERVICES Media Preparation& TECHNOLOGY Glassware Preparation
Office Services Comparative PathologyResearch & Development Program Plant Safety Germ-free Animal Production
in Which Concepts & Methods of Supply Management Biomedical Engineering andComputer Science Are Applied to Financial Management InstrumentationBiomedical Problems (Services Are Personnel Management Library ServicesRendered to the NIH Communities Management Policy Medical Artson a Fee-For-Service Basis). Management Survey and Review Environmental Services
NATIONAL CANCER INSTITUTE OBLIGATIONS AND EXPENDITURES
O
650,000
600,000
550,000
500,000
450,000
ARS 400,000O° 350000,
D 300,000aS
250,000T
200,000
150,000
100,000
50,000
1968 1969 1970 1971 1972 1973 1974FISCAL YEAR
(estimate)
OBLIGATIONS: Orders placed, grants and contracts awarded, salaries earned and similar financial transactions which legally utilize or reserve an appropriation for expenditure.
EXPENDITURES : Payments (cash or checks, made from current or prior year appropriations.
DISTRIBUTION OF PERSONNEL BY FUNCTION
700
600
500
400
300
32
1967 1968 1969 1970 1971 1972 1973
........ Scientific
- Administrative
Technical and Supporting
Percent of Actual Employment
Fiscal Year
1967 1968 1969 1970 1971 1972 1973
Scientific 33.9% 37.5% 37.8% 38.3% 37.5% 36.2% 37.3%
Administrative 27.5% 25.5% 24.4% 24.0% 23.9% 27.3% 27.6%
Technical and Supporting 38.6% - 37.0% 37.8% 37.7% 36.6% 36.5% 35.1%
Total Actual Employment 1329 1453 1411 1355 1426 1665 1736
COMPARISON OF DOLLARS, PO
1971
1972
1973
1974(estimate)
1975(estimate)
*Does not include field station-assigned space.
S AN SPACE
DOLLARS POSITIONS SPACE
PERCENT OF PERCENT OF FULL-TIME PERCENT OF PERCENT OF ALLOCATED PERCENT OF PERCENT OFOBLIGATIONS INCREASE INCREASE PERMANENT INCREASE INCREASE SPACE INCREASE INCREASE
($000'5) OVER OVER EMPLOYEES OVER OVER (SQUARE OVER OVERBASE YEAR PRIOR YEAR BASE YEAR PRIOR YEAR FEET)* BASE YEAR PRIOR YEAR
Base Base Base232,855 year 1426 Year 321,230 year
378,636 62.6 62.6 1665 16.8 16.8 329,587 2.6 2.6
431,245 85.2 13.9 1736 21 .7 4.3 357,972 11 .4 8.6
589,155 153.0 36.6 1820 27,6 4.8 384,972 19.8 7.5 .
600,000 157.7 1 .8 1855 30.1 1.9 390,272 21.5 1 .4
$12,053,
RESEARCHGRANTS
$120,150,000(49.6%)
RESEARCHSUPPORTCONTRACTS$70,094,000
(28.9%)
EARCHGRANTS$157,663,00 0(53
oJ
$10,136,000
RESE9,Q01 6,
RESEARCHCONTRACTS$39,902,000(16.5%)
RESEA
CH GRANTS $120,150Ó
RCH SUPPORT CGN
RESEARCHGRANTS
$157,663,000(53.7%)
RESEARCHGRANTS
$217,587,000(54.7%)
$11,832,000
RESEARCHCONTRACTS$88,005,000
(22.1%)
RESEARCHSUPPORT
CONTRACTS$80,532,000(20.21/° )y
SUPPORT CONTRAC
537,0000
COMPARISON OFRESEARCH GRANTS/RESEARCH ANDRESEARCH SUPPORTCONTRACTS
1972$242,199,00
INTERAGENCYAGREEMENTS$12,053,000
(5.0%)
INTERAGENCYAGREEMENTS$10,136,000
(3.4% /o)
INTERAGENCYAGREEMENTS$11,832,000
(3.0%)
1973$293,824,000
m .9
1974RESEA
O 6,025,000ARCH GRANTS $217,, $397,956,000
AR CH
SUPPORT CONTRACTSRESE 7, o0̀
4.7%óJ
TOTAL NCI DOLLARS BY MECHANISMS - FISCAL YEAR 1974
TOTAL$589,155,000
INTERAGENCY AGREEMENTS$11,832,000 (2.0%)
26
RESEARCH$35,561,000
(6.0%)
NCI/NIH MANAGEMENT$33,086,000 (5.6%)
w
v 25,724, ACTIVr
GRANTS $293,279,000 149'8
ó
RESEARCH$88,005,000
(14.9%)
RESEARCH GRANTS$217,587,000
(36.9%)
$7,050,000 (1.2%)
NOTE : Management includes NCI Management as well as NIH Management Fund .
CANCERCONTROL
NCI/NIHMANAGEMENT
35
(36.6%)1
1 ,000$215, 3g
1(1
TROL
RESEARCHSUPPORT
ERo 000$80,532,000
(13.7%) O2 000
RESEARCH POSITIONS AT THE NATIONAL CANCER INSTITUTE'
1. CIVIL SERVICE .
The National Cancer Institute recognizes that one of the most valuable resources tobe drawn upon in the fight against cancer is the wealth of scientific talent availablein the U.S . and around the world. In an effort to attract and maintain the highestquality scientific staff, two personnel systems are used : the U .S . Civil ServiceSystem and the PHS Commissioned Corps. In addition, the Staff Fellowship Programand the NIH Visiting Program have been designed to meet special needs. Specialprograms are also available for those who qualify.
POSITION)
-
ELIGIBILITY
ANNUAL SALARYMECHANISM OF ENTRY
11 .
SPECIAL APPOINTMENT OF EXPERTS AND CONSULTANTS
III. USPHS COMMISSIONED CORPS
36
Associate Training Program including CORD residency deferment program (limited tenure, maximum 3 years)2
Clinical Associate Graduates of Medical Schools in- Pay and allowances of Apply to ClinicalI
and Professionalcluding Internship Senior Assistant Surgeon Education Section, Clinical Center,
or Surgeon of PHSSurgeon
National Institutes of Healthmissioned Corps
B. Research Associate Graduates of Medical Schools in- Pay and allowances of Apply to Clinical and Professionalcluding Internship Senior Assistant Surgeon Education Section, Clinical Center,
or Surgeon of PHS tom- National Institutes of Healthmissioned Corps
Staff Associate Graduates of medical and dental Pay and allowances of Apply to Clinical and Professionalschools, or other doctoral Senior Assistant Surgeon Education Section, Clinical Center,qualifications of PHS Commissioned National Institutes of Health
Corps.
D. Senior COSTEP Senior Medical Students Pay and Allowances of Apply to Clinical and ProfessionalProgram (Medical) Junior Asst. Health Ser- Education Section, Clinical Center,
vice Officer plus payment National Institutes of Healthof tuition, fees and othernecessary expenses . Can-didates incur 2 year ac-tive duty obligation withPHS CommissionedCorps.
A., Civil Service Appropriate advanced education, ex- Minimum starting: Civil Service Commission. Contact(tenured) perience and knowledge needed by Ph.D. - $20,677 Director or Laboratory Chief in area of
NCI to conduct its programs Physicians - $26,189 interest or the NCI Personnel Office.Maximum: $36,000
A. Special Appointment of Applicants shall possess outstanding Equivalent to the salary Recommendation by Division Direc-Experts and Con- experience and ability such as to range of GS-16 through tors. Final approval rests with thesultants (non-tenured justify recognition as authorities in GS-18 Director, NCI.appointment which can their particular fields of activity .be extended up to 4 Maximum: $36,000years)
IV. VISITING PROGRAM (limited tenure)3
V. STAFF FELLOWSHIPS
VI. SPECIAL PROGRAMS ;
1 Does not necessarily indicate that positions are currently available at the National Cancer Institute.2 Appointments are made upon intellectual attainment and demonstrated research interest and ability matched to NCI's needs .3 Under most circumstances, the various visiting programs are limited to non-citizens .
37
POSITION ELIGIBILITY ANNUAL SALARY ; MECHANISM OF ENTRY '
A. Visiting Fellow 1-3 vears postdoctoral education $7,000-10,000 plus Contact Director or Laboratory Chief(maximum 3 years) $1,000 for each of first in area of interest .
two dependents and $500for each additionaldependent
B. Visiting Associates 3+ years postgraduate education $12,000-17,500 Contact Director or Laboratory Chief(1 year with renewals to' with appropriate knowledge needed in area of interest.end of project) by NCI
C. Visiting Scientist 6+ years postdoctoral education $20,000-36,000 Contact Director or Laboratory Chief(duration of project) with appropriate unusual experience in area of interest .
and knowledge needed
A. Staff Fellowships Physician or other doctoral degree Staff Fellows Contact Director or Laboratory Chief(maximum 6 years) equivalent awarded within last 5 Ph sicians in area of interest or the NCI Per-
years, U.S. citizen or non-citizen 17,900-21,500 sonnel Office.eligible for naturalization within 4 Other Doctoratesyears. $13,700-20,000
Senior Staff FellowsPh sicians
20,200-28,200Other Doctorates
$17,900-22,800
A. Research Fellow spon- Determined by sponsoring Established by spon- Contact Director or Laboratory Chiefsored by organization
Iorganization. spring organization in area of interest; also apply to spon-
other than NIH, PHS spring agency, e.g. American CancerSociety, Eleanor Roosevelt Cancer .Foundation, Leukemia Society ofAmerica, Inc., etc.
B. COSTEP Program (oper- U.S. citizen with 2 years of bac- Pay and allowance of a Apply to PHS Commissioned Corps,ates year-round) Max- calaureate program or more in Commissioned Officer, COSTEP SECTION, Parklawnimum 120 days per 12' health-related field: May be enrolled Junior Asst. Grade Building, 5600 Fishers Lane, Rock-month period in doctoral program or professional ville, Maryland 20852.
school . Physical requirements of - --PHS Commissioned Corps. Plans toreturn to college .
C. Civil Service U.S. citizen, 18 years of age or older Pay equivalent to GS-1 Civil Service Summer EmploymentSummer Employment (16 if high school graduate) through GS-4 depending Examination (waived for outstandingProgram on education and ex- 3rd year college engineering or
perience physical science students)
College graduates, graduate Pay equivalent to GS-5 Apply to NIH Personnel Staffingstudents, faculty members, through GS-12 Branch.equivalent experience .
D. Fogarty International International reputation, produc- $30,000 per annum Recommendation to Fogarty CenterScholars tivity, demonstrated ability in by Institute Director or Scientist
biomedical field Contact Director in area of interest.
W38
NCI CONTRACTS ADMINISTRATION PROCESS - UNDER CANCER ACT OF 1971
TIME
I
MONTHS
0 1 2 3 4 5 6ORGANIZATION
PROGRAM
ADVISORY
GROUPS ADVISEPROGRAM,STAFF
DEVELOP PREPAREPROJECT I PROPOSALSITE VISITS ANOREVIEW,
PROGRAM ,PEN
MENTS WORK STATE AND PREPAREPROPOSAL
NCI PROGRAM ESTABLISH OBJECTIVES SPECIFICATIONS EVALUATE'SUMMARY
ADMINISTER
STAFF .PROJECT AREAS . ESTABLISH
PROJECT RELEVANCE, SET PRIORITIESRESUMES A IL NEGOTIATECONTRACT CONTRACT
III PROPOSAL REVIEW,
NCI RESEARCH ADVERTISE PROJECTSSITE VISITS ANDPREPAREPROPOSAL EXECUTE CONTRACT
ANDAWARD ADMINISTERPREPARE WORK IN CBO EVALUATE'
SUMMARY CONTRACTCONTRACTS, STATEMENTSAND RESUMES
SPECIFICATIONS '- QUALIFIED NEGOTIATEBRANCH SGURCES CONTRACT
CONTRACTOR . CUTE'CONTRACT
SUBMITRESUMES SUBMIT
NEGOTIATECONTRACT
PROPOSAL
CONTRACT I C RECO TRACTORREVIEW REVIEW PROPOSALS
COMMITTEEFORMERIT
SCIENTIFIC
NOTE :LEGEND
SIMULTANEOUS ACTIVITIES BY MORE THAN ONEORGANIZATION INDICATE COOPERATIVE EFFORTS, -OPERATION NORMALFLOW
-REVIEW NON-COMPETITIVE CONTRACTS
- DECISION AD HOC COMMITTEES MAYBEUSED -INCLUDES OUTSIDE SCIENTISTS
CONTRACTORS RECEIVING MORE THAN $750,000 IN NCI
(THOUSANDS OFRESEARCH CONTRACT FUNDS -- FISCAL YEAR 1973DOLLARS)
SUBTOTAL -
2691
$ 92,271241 Contractors receiving MORE than $750,000 (listed above)SUBTOTAL -
427
48,859
214 Contractors receiving LESS than $750,000 (not listed)
696 $141,130
1269 represents 39% of the 696 contracts awarded.
'2$92,271,000 represents 65% of the $141,130,000 awarded in FY 1973 .
39
PERCENT OF NUMBER OF AMOUNT CONTRACTOR STATETOTAL DOLLARS CONTRACTS
21 $ 16,515 Litton Bionetics Maryland12 6,311 Microbiological Associates Maryland11 4,076 Southern Research Institute Alabama14 3,950 Hazleton Laboratories Virginia4 3,465 Flow Laboratories Maryland35%1 3,446 University of Nebraska Medical Center NebraskaC
0 11 3,435 Meloy Laboratories Virginia16 3,109 Atomic Energy Commission Tennessee5 3,023 University of Southern California California4 2,862 American Health Foundation New York
7 2,660 Arthur D . Little, Inc . MassachusettsS 1 2,490 U.S . Public Health Service Marylandm
9 2,275 Stanford Research Institute California11 2,187 University of Texas M.D . Anderson Hosp . Texas1 2,160 Veterans Administration Dist. of Col .3 2,045 Pfizer, Inc . New Jersey
20 12 2,033 Mason Research Institute Massachusetts7 2,027 Illinois Institute of Technology Illinois5 1,718 California State Dept . of Public Health California5 1,432 St . Louis University Missouri
3 1,384 Life Sciences, Inc. Florida4 1,370 Battelle Memorial Institute Ohiom5 1,245 Columbia University New York4 1,199 Electro-Nucleonics Laboratories Maryland7 1,104 University of Pennsylvania Pennsylvania
45 3 1,084 Charles River Breeding Laboratories Massachusetts2 1,080 JRB Associates Virginia8 1,044 Johns Hopkins University Maryland8 1,042 Midwest Research Institute Missouri10 1,010 Mayo Foundation Minnesota
7 972 University of California Los Angeles California5 959 A. R . Schmidt Company Wisconsin9 928 University of Minnesota Minnesota3 905 Upjohn Company Michigan8 895 University of Chicago Illinois2 871 Merck and Company New Jersey7 840 New York University New York4 793 Bristol Laboratories New York6 789 Dow Chemical Company Michigan4 788 University of Pittsburgh Pennsylvania
10 750 National Academy of Sciences Dist . of Col .
DISTRIBUTION OF CONTRACTS BY NCI PROGRAM AREAAND BY TYPE OF INSTITUTION - FISCAL YEAR 1973
40
PERCENT OFTOTAL NUMBEROF CONTRACTS
NUMBER OFCONTRACTS NCI PROGRAM AREA
THOUSANDSOF DOLLARS
225Division of Cancer $ 43,866Treatment
336 Division of Cancer Cause 77,649and Prevention
116 Division of Cancer Biology 14,646and Diagnosis
19 Cancer Control 4,969
696 Total $141,130
TS ADMINISTRATION
NOTE: SIMULTANEOUS ACTIVITIES BY MORE THAN ONEORGANIZATION INDICATE COOPERATIVE EFFORTS
UNDER CANCER ACT OF 1971w, ~ x
LEGEND :
OPERATIONS
REVIEW
- DECISION
NORMAL ADMINISTRATIVE FLOW
©
APPLICATIONS LESS THAN $35,000 TOTAL COSTS (TIME SAVING 3 TO 4 WEEKS)
------- * SITE VISITS REQUIRED FOR ONLY ABOUT 10% of APPLICATIONS
NCAB MEETS NOT LESS THAN 4 TIMES PER YEAR
TIME (MONTHS)ORGANIZATION
0 1 2 3 4 5 8 7 8
PREPAREIPARTICIPATE 1N
APPLICATION NEGOTIATIONSAPPLICANT RECEIVEINSTITUTION
NOTICE OF AWARDRECEIVE RECOMMENDATIONS RECEIVEDNOTICE OF
o oIN
ASSIGN RECOMMENDATIONS NEGOTIATIONSAPPROPRIATE AWARD
oNCI/DCRRC APPLICATIONS FUNDING RECEIVED NEGOTIATIONSSUBMITS TO NCI REVIEW DETERMINATIONS AND FINAL
DIVISION OF GUIDELINESINES IDENTIFIES COMMITTEEMADE ¡ REVIEW
CANCER RAM _ o SUMMARY ---o-- .10RESEARCH
RELEVANCE_
ASSIGN TO ATTENDTS
MAILED STATEME TOAWARD
f NEGOTIATIONS AWARD STATEMENTESTABLISHESPROGRAM PROGRAM IRG MEETING NCAB MEMBERS
AND FINAL STATEMENTPREPARED AND PREPARED ANDRESOURCES AREAS DIRECTOR AS OBSERVER REVIEW . MAILED MAILEDAND CENTERS DEVELOPS o FUNDING- NCI - PROGRAM ATTEND
ODEETERMINATIONSOBIEC TIVES
PICASASSIGN TO MEETING
DIVISION OF INSTITUTE
RESEARCHGRANTS ASSIGN
APPROPRIATE- NIH (DRG) - DETERMINE APPLICATIONSRESEARCH To INITIALAREA REVIEW GROUP (IRG), SUMMARY
STATEMENTSPREPARED
INITIAL SECRETARYEXECUTIVE_ _ _
oEXECUTIVEREVIEW REVIEW IRGMEMBER /* IRG MEETING SUMMARY SECRETARIES
AND REVIEW VOTE STATEMENTS ATTEND NCABGROUP REVIEW SITE VISIT AND ASSIGN PRINTED MEETINGREPORT /
'PRIORITY
- NIH (IRG) -o-----o
SITE VISIT-
NATIONALCANCERADVISORY **CONSIDERAPPLICATIONSBOARD AND MAKE
RECOMMENDATIONS
INSTITUTIONS RECEIVING MORE THAN $750,000 INNCI RESEARCH GRANT FUNDS - FISCAL YEAR 1973
(THOUSANDS OF DOLLARS)
48 Institutions receiving MORE than $750,000 (listed above)
234 Institutions receiving LESS than $750,000 (not listed)
11,060 represents 63% of the 1692 grants