Neuropathology Case ConferenceNeuropathology Case Conference

12/02/2005

Case 2:Case 2:

62 y/o Female, Progressive left upper 62 y/o Female, Progressive left upper extremity numbness, extremity numbness, S/P liver transplantS/P liver transplant

Differential DiagnosisDifferential Diagnosis

Malignant MelanomaMalignant Melanoma

Foreign Body Type ReactionForeign Body Type Reaction

Glial NeoplasmGlial Neoplasm

PhaeohyphomycosisPhaeohyphomycosis

Cerebral PhaeohyphomycosisCerebral Phaeohyphomycosis

Dematiaceous fungi (darkly pigmented fungi)

1. Phaeohyphomycosis (CNS cases: Cladophialophora bantiana)

2. Chromoblastomycosis (CNS cases: Fonsecaea pedrosoi)

Dark, thick-walled muriform cells (sclerotic bodies)

• High mortality (70% in C. bantiana) and morbidity

• Fungi identified on frozen section/ touch prep