New Therapeutic Approaches Aimed at Eliminating Persistent
HIV Reservoirs in InfectedIndividuals ReceivingAntiretroviral Therapy
Tae-Wook Chun, Ph.D.Laboratory of Immunoregulation
National Institute of Allergy and Infectious DiseasesNational Institutes of Health
Department of Health and Human Services
Potential Strategies for Eradication of HIV
Early initiation of antiretroviral therapy
Use of immune-modulating agents
Addition of newer classes
of drugs
Use of virus “purging” agents
Use of HIV-specific killing agent
Potential Strategies for Eradication of HIV
Early initiation of antiretroviral therapy
Use of immune-modulating agents
Addition of newer classes
of drugs
Use of virus “purging” agents
Use of HIV-specific killing agent
Potential Strategies for Eradication of HIV
Early initiation of antiretroviral therapy
Use of immune-modulating agents
Addition of newer classes
of drugs
Use of virus “purging” agents
Use of HIV-specific killing agent
Potential Strategies for Eradication of HIV
Early initiation of antiretroviral therapy
Use of immune-modulating agents
Addition of newer classes
of drugs
Use of virus “purging” agents
Use of HIV-specific killing agent
Potential Strategies for Eradication of HIV
Early initiation of antiretroviral therapy
Use of immune-modulating agents
Addition of newer classes
of drugs
Use of virus “purging” agents
Use of HIV-specific killing agent
Persistence of HIV in Gut-Associated LymphoidTissue despite Long-Term Antiretroviral TherapyTae
Persistence of HIV in Gut-Associated Lymphoid
Tissue despite Long-Term Antiretroviral Therapy
Chun et al.
Effect of Raltegravir Intensification on Immunologic and Virologic Parameters of HIV-Infected, Aviremic Individuals
Buzon et al., Nature Medicine, 16 (4): 460-5, 2010
Changes in Levels of Cell-Associated Unspliced HIV RNA in Infected Individuals who Underwent Intensification of ART
Yukl et al., personal communication