NSF-NSEC for Integrated Nanopatterning and Detection TechnologiesNSF-NSEC for Integrated Nanopatterning and Detection Technologies(NSEC Grant Number EEC – 0647560)(NSEC Grant Number EEC – 0647560)
Chad Mirkin (PI), Michael Bedzyk, Vinayak Dravid, Horacio Espinosa, Franz Geiger, Mark Hersam, Joseph Hupp, SonBinh Nguyen, Monica Olvera de la Cruz, George Schatz, Richard Van Duyne, William Klein, Chang Liu, Milan Mrksich, Steve Sligar, Teri Odom,
Steve Wolinsky, Laurie Zoloth, Mercouri Kanatzidis, Jiaxing Huang, C. Shad Thaxton
Northwestern University, University of Chicago, University of Illinois at Urbana-Champaign
SRG 1: Nanopatterning
2 nm
Dip-Pen Nanolithography Feedback Controlled Lithography Heteromolecular 10 million Pen Array Intermolecular spacing with atomic precision Nanostructures
SRG 3:Integrated Biodetection ChipSRG 2: Signal Transduction & Receptor Design
Flow cellLamp Spectrometer
Flo
w
Aperture
250 nm
Drug Binding to Membrane Proteins
Alkanethiolate
Alkyldisulfide
m/z
Detector
MS
Detection Strategies Enabled by NanoMaterialsNew Receptor Chemistries
Measuring Telomerase Activity Profiling HDAC ActivityAc-GXKAcZGC-NH2
D N E Q K R H S T M W F Y V I L A G PDNEQKRHSTMWFYVILAGP
Z Po
sitio
n
X Position
0 1
Polymer Pen Lithography 2-D Active Probe Arrays Parallel Inking Wells
Education and Outreach
Research Experience for Undergraduates Research Experience for Teachers
Nanoscape: The Journal of Undergraduate Research in Nanoscience
93 articles published to date
Undergraduate authors from institutions across the country
Volume VIII to be released Summer 2011
On-line and print version
Print version mailed to >1,000 college and university departments and libraries
208 REU participants to date
50% of participants women and underrepresented minorities
Hands-on research plus professional development activities– Technical writing course– Public Speaking workshop– Tour of Argonne National Laboratory– Final symposium and written paper– Over 90 published papers
Program includes hands-on research and curriculum development for their classrooms
81 pre-college teachers have participated to-date
~9000 pre-college students impacted to-date
Partnership with the Museum of Science and Industry, Chicago
Resulting in 2,400 square ft permanent exhibit on nanotechnology
Opening 2011 Potential to reach over 2 million visitors per year
DiscoverNano Website (www.discovernano.northwestern.edu)
>900,000 visitors a year Includes:
– Introduction to nanotechnology– Historical timeline– Nano Art gallery– Curriculum projects– Meet the Researchers section
Nanotechnology Town Hall Meetings Introduces nanotechnology to the public Addresses societal/ethical concerns 7 meetings held, ~600 attendees to date
Nanoscience Pre-college Module Inquiry-based, links to real-world applications,
extensively field-tested Includes student & teacher manuals Being disseminated world-wide by NCLT
Knowledge Transfer (to-date)
726 publications
193 provisional patents
1,444 domestic and international seminars & colloquia
97 Frontiers in Nanotechnology Seminars
7 International Institute for Nanotechnology Symposiums
16 start-up companies launched through Small Business Evaluation & Entrepreneur’s (SBEE) Program (>$500M in VC invested)
20 companies enlisted in Nanotechnology Corporate Partners (NCP) program
70 Industrial partnerships
47 International partnerships
Integrated chip-based detection systemIntegrated chip-based detection system
Improved bio-barcode assay
Protein biomarker identification
Surface immobilized bio-barcode assay
The authors thank the National Science Foundation
for support of this work.
MOSFET-embedded microcantilever development
Integration of novel receptors with nanomechanical detection platform