Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 79, No. 17, [Part 1: Biological Sciences] (Sep. 1, 1982), pp. i-vPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/12485 .

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4 ' c's OF1

Procee OF T

National i

of Sci OF THE UNITED STI

September 1982 Volume 79, N

Table of C

AUTHOR INDEX

Biological Sciences

BIOCHEMISTRY

Adaptive resynthesis of 06-methylguanine-accepting protein can explai differences between mammalian cells proficient and deficient in mel excision repair (adaptation/cell survival/DNA repair/N-methyl-N'- N-nitrosoguanidine)

Mechanism of the inhibition of mutagenicity of a benzo[a]pyrene 7,8-di epoxide by riboflavin 5'-phosphate (ultimate carcinogen/Ames' Saln typhimurium/kinetics of epoxide hydrolysis/general acid catalysis/c formation)

Purine oversecretion in cultured murine lymphoma cells deficient in adenylosuccinate synthetase: Genetic model for inherited hyperuric gout (inosine/purine salvage/hypoxanthine/guanine phosphoribosylt

Identification of cloned Y chromosomal DNA sequences from a lampbru Drosophila hydei (spermatogenesis/recombinant DNA/gene structure hybridization)

cAMP stimulates transcription of the gene for cytosolic phosphoenolpyr carboxykinase in rat liver nuclei (nuclear RNA precursor/phosphoe] carboxykinase mRNA turnover/blot hybridization)

Methylation of simian virus 40 Hpa II site affects late, but not early, vi expression (DNA methylation/simian virus 40 viral capsid protein V tumor antigen synthesis/microinjection of Xenopus laevis oocytes)

[LeuB24]Insulin and [AlaB24]insulin: Altered structures and cellular pro B24-substituted insulin analogs (insulin metabolism/insulin recepto structure/semisynthetic analogs/rat hepatocytes)

clings HE

kcademy :nces

kTES OF AMERICA

umber 17 pp. 5117-5444

ontents

vii-viii

n the E. A. Waldstein, E.-H. Cao, and 5117-5121 ;hyl R. B. Setlow titro-

o1 9,10- Alexander W. Wood, Jane M. Sayer, 5122-5126 onella Harold L. Newmark, Haruhiko Yagi, omplex Dennis P. Michaud, Donald M.

Jerina, and A. H. Conney Buddy Ullman, Mary Anne Wormsted, 5127-5131

,mia and Marvin B. Cohen, and David W. ransferase) Martin, Jr. sh loop of Peter Vogt, Wolfgang Hennig, and 5132-5136 7/in situ Ingrid Siegmund

ivate Wouter H. Lamers, Richard W. 5137-5141 iolpyruvate Hanson, and Herman M. Meisner

ral gene Anny Fradin, James L. Manley, and 5142-5146 P-1 and Carol L. Prives

:essing of R. K. Assoian, N. E. Thomas, 5147-5151 rs/insulin E. T. Kaiser, and H. S. Tager

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Contents

Sequence of a cDNA encoding pancreatic preprosomatostatin-22 (recom DNA/DNA sequence analysis)

Purified glucocorticoid receptor-hormone complex from rat liver cytoso: specifically to cloned mouse mammary tumor virus long terminal re vitro (steroid hormone receptor/DNA-protein interaction/transcripti regulation)

Removal of 06-methylguanine from DNA by human liver fractions (D\ carcinogenesis)

Regulated expression of human interferon 13i gene after transduction ir cultured mouse and rabbit cells [plasmid transducing vectors/domir selectable marker (neo)/transduction of animal cells/interferon indu

Use of a fluorescent cholesterol derivative to measure lateral mobility cholesterol in membranes (4-nitrobenzo-2-oxa-1,3-diazole-labeled ch fluorescence recovery after photobleaching)

Aminofluorene-DNA adduct formation in Salmonella typhimurium exi carcinogen N-hydroxy-2-acetylaminofluorene (mutagenesis/deacyla paraoxonI/N-hydroxy-2-aminofluorene)

Hormone receptor modulates the regulatory component of adenylyl cyce reducing its requirement for Mg2+ and enhancing its extent of activ guanine nucleotides (guanosine 5'-[y-thio]triphosphate/reconstitutic analysis/cyc- S49 cell membrane adenylyl cylase/glucagon)

Ribosomal protein S4 is an internal protein: Localization by immunoelE microscopy on protein-deficient subribosomal particles (ribosome as, fidelity/RNA binding protein)

Fragments of the simian virus 40 transforming gene facilitate transfor: rat embryo cells (recombinant plasmids/immortalization/large tums

Characterization of the inactive form of fructose-1,6-bisphosphate aldol isolated from livers of fasted rabbits (lysosomal proteinases/catheps M/leupeptin/benzoyl-L-arginyl-2-naphthylamide)

Argininosuccinate synthetase of bovine liver: Chemical and physical pi (enzyme characterization/sequence analysis aid for human gene proc

A prokaryotic membrane anchor sequence: Carboxyl terminus of bacte: gene III protein retains it in the membrane (filamentous phage/me; proteins/domain structure/fusion proteins/membrane topogenesis)

Regulation of synthesis and degradation of 3-hydroxy-3-methylglutary A reductase by low density lipoprotein and 25-hydroxycholesterol ir (compactin/drug resistance/cholesterol metabolism/mevalonate/cry, endoplasmic reticulum)

Molecular cloning and chromosomal mapping of a human locus related transforming gene of Moloney murine sarcoma virus [recombinant 1 (human)/physical map/somatic cell hybrids/chromosomal assignme

In vitro transcription of the thymidine kinase gene of herpes simplex v (uninfected HeLa cell extract/early and late genes/transcriptional co elements/RNA polymerase IIl/promoter sequences)

Viroids and prions (potato spindle tuber disease/scrapie/proteinaceous i particles/infectious RNA)

Separation of the adenovirus terminal protein precursor from its associ polymerase: Role of both proteins in the initiation of adenovirus DI replication (adenovirus genome/aphidicolin)

Sarcomeric myosin heavy chain is coded by a highly conserved multige: (evolution of myosin heavy chain genes/gene amplification/DNA rearrangement/myosin heavy chain allelic polymorphism)

Sequence studies of several alphavirus genomic RNAs in the region col the start of the subgenomic RNA (Sindbis virus/RNA sequence dete sequence homology/nonstructural proteins/transcription initiation)

Rapid and transient localization of the leader RNA of vesicular stomat in the nuclei of infected cells (negative RNA strand viruses/shutoff transcription/cell nucleus/viral transcription)

ii

binant Marilyn Magazin, Carolyn D. Minth, 5152-5156 Christie L. Funckes, Robert Deschenes, Marie A. Tavianini, and Jack E. Dixon

binds Manjapra Variath Govindan, Eberhard 5157-5161 peats in Spiess, and John Majors mn

A repair/ Anthony E. Pegg, Marcel Roberfroid, 5162-5165 Christer von Bahr, Robert S. Foote, Sankar Mitra, Henriette Bresil, Alexei Likhachev, and Ruggero Montesano

.to D. Canaani and P. Berg 5166-5170 ant ction] )f M. R. Alecio, D. E. Golan, W. R. 5171-5174 olesterol/ Veatch, and R. R. Rando

osed to the David T. Beranek, Gail L. White, 5175-5178 ;e/ Robert H. Heflich, and

Frederick A. Beland

ase by Ravi Iyengar and Lutz Birnbaumer 5179-5183 ation by n

ctron Donald A. Winkelmann, Lawrence 5184-5188 rembly/ Kahan, and James A. Lake

nation of Wendy W. Colby and Thomas Shenk 5189-5193 ,r antigen) ase S. Pontremoli, E. Melloni, M. Michetti, 5194-5196 :n F. Salamino, B. Sparatore, and

B. L. Horecker

operties Sarah Ratner 5197-5199 luct)

^iophage fl Jef D. Boeke and Peter Model 5200-5204 nbrane

-coenzyme Jerry R. Faust, Kenneth L. Luskey, 5205-5209 UT-1 cells Daniel J. Chin, Joseph L. Goldstein,

rtalloid and Michael S. Brown

to the K. Prakash, O. W. McBride, D. C. 5210-5214 )NA/c-mos Swan, S. G. Devare, S. R. Tronick, nt] and S. A. Aaronson

rus G. Sullivan Read and William C. 5215-5219 ntrol Summers

nfectious T. O. Diener, Michael P. McKinley, and 5220-5224 Stanley B. Prusiner

ated DNA Jack H. Lichy, Jeffrey Field, Marshall 5225-5229 TA S. Horwitz, and Jerard Hurwitz

ie family Hanh Thi Nguyen, Ruth M. Gubits, 5230-5234 Robert M. Wydro, and Bernardo Nadal-Ginard

ltaining Jing-hsiung Ou, Charles M. Rice, Lynn 5235-5239 rmination/ Dalgarno, Ellen G. Strauss, and

James H. Strauss

itis virus Michael G. Kurilla, Helen Piwnica- 5240-5244 of host Worms, and Jack D. Keene

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Contents

In vitro replication of bacteriophage 429 DNA (linear DNA replication/ priming model/initiation of DNA synthesis)

Calcium/phospholipid regulates phosphorylation of a Mr "87k" substral in brain synaptosomes (phosphoprotein/protein kinase/phosphatidyl calcium influx/nerve terminal)

Transcriptional control of the murine albumin/a-fetoprotein locus durhi development (RNA hybridization/developing,liver/differentiation/m

BIOPHYSICS

Neutron scattering studies and modeling of high mobility group 14 core nucleosome complex (chromatin/gene activation/transcription)

A model for catabolite activator protein binding to supercoiled DNA (ge expression/protein-DNA interactions)

Dynamics and time-averaged chemical potential of proteins: Importanct oligomer association (enolases/fluorescence/equilibria)

BOTANY

Native phytochrome: Inhibition of proteolysis yields a homogeneous mo 124 kilodaltons from Avena (hot NaDodS04 extraction/protease inhi solid-phase immunoprecipitation/one- and two-dimensional gel-elect

Formation of hybrid phycobilisomes by association of phycobiliproteins Nostoc and Fremyella (energy transfer/blue-green algae/photosynthe accessory pigment)

CELL BIOLOGY

Requirement for a membrane potential for cellulose synthesis in intact I Acetobacter xylinum (protonmotive force/plasma membrane/glucan/ polysaccharide biosynthesis)

Carcinogen-transformed human cells are inhibited from entry into S ph fusion to sensecent cells but cells transformed by DNA tumor viruse the inhibition (cell cycle/heterokaryons/simian virus 401chemical transformation)

Unusual retention of rhodamine 123 by mitochondria in muscle and car cells (membrane potential/carcinogenesis/diagnosis/chemotherapy)

Monensin inhibits Semliki Forest virus penetration into culture cells (cl ionophores/virus entry/lysosomotropic agents/lysosomes/cell fractioi

Karyophilic proteins: Polypeptides synthesized-in vitro accumulate in t1 on microinjection into the cytoplasm of amphibian oocytes (cellular compartmentalization/nuclear transport/nuclear envelope/post-trans modification)

Modulation of synovial cell products by a factor from a human cell line: T lymphocyte induction of a mononuclear cell factor (U937 cells/clo human T cells/monokine/lymphokine/rheumatoid arthritis)

Serum contains a platelet.derived transforming growth factor (growth ii agar/cell transformation/bovine serum/human serum)

Electron microscopic study of natural killer cell-tumor cell conjugates (4 mechanism/degranulation/lysosomal enzymes/immune surveillance)

Immunofluorescent localization of the transforming protein of Rous sar with antibodies against a synthetic src peptide (antipeptide antibodie sarcoma virus-transformed fibroblasts)

Dependence of locally measured cellular deformability on position on th temperature, and cytochalasinB (cytoskeleton/mechanical properties cytotensiometer/microfilaments)

iii

protein- Kounosuke Watabe, Meng-Fu Shih, 5245-5248 Akio Sugino, and Junetsu Ito

e protein Wilson C.-S. Wu, S. Ivar Walaas, 5249-5253 serine/ Angus C. Nairn, and

Paul Greengard

ig ShirleyM. Tilghman and 5254-5257 odulation) Alexandra Belayew

Edward C. Uberbacher, James K. W. 5258-5262 Mardian, RandallM. Rossi, Donald E. Olins, and Gerard J. Bunick

rie F. R. Salemme 5263-5267

!in Gen-jun Xu and Gregorio Weber 5268-5271

aomer of Richard D. Vierstra and Peter H. Quail 5272-5276 bitors/ rophoresis) from Ora Canaani and Elisabeth Gantt 5277-5281 tic.

sells of Deborah P. Delmer, Moshe Benziman, 5282-5286 and Etana Padan

ase by Gretchen H. Stein, Rosalind M. 5287-5291 3 overcome Yanishevsky, Lena Gordon, and

Mary Beeson

cinoma Ian C. Summerhayes, Theodore J., 5292-5296 Lampidis, Samuel D. Bernal, John J. Nadakavukaren, Karen K. Nadakavukaren, Elizabeth L. Shepherd, and Lan Bo Chen

irboxylic Mark Marsh, Jennifer Wellsteed, 5297-5301 ration) Hildegard Kern, Erik Harms, and

Ari Helenius e nucleus Marie-Christine Dabauvalle and 5302-5306

Werner W. Franke lational

Edward P. Amento, James T. Kurnick, 5307-5311 ted Alan Epstein, and, Stephen M. Krane

' soft Chris Bjornson Childs, Jacqueline A. 5312-5316 Proper, Ronald F. Tucker, and Harold L. Moses

'ytotoxic Tom Frey, Howard R. Petty, and 5317-5321 Harden M. McConnell

coma virus E. A. Nigg, B. M. Sefton, T. Hunter, G. 5322-5326 s/Rous Walter, and S. J. Singer

cell, Nils O. Petersen, William B. 5327-5331 / McConnaughey, and Elliott L. Elson

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Contents

DEVELOPMENTAL BIOLOGY

DNA methylation in chicken,a-globin gene expression (restriction mapl recombinant DNA /erythrocyte/differentiation)

EVOLUTION

Somatic cell parasitism and the evolution of somatic tissue compatibilil (chimera/Dictyostelium mucoroides/frequency-dependent,selection/ rejection/self/not-self)

GENETICS

Tandem gene amplification mediates copper resistance in yeast (tanden repeats/heavy metal)

Incompatibility of plasmids containing the replication origin of the Esc coli chromosome (recA strain/oriC-vector hybrid/segregation)

Single-copy sequence hybridizes to polymorphic and homologous loci on and Y chromosomes (restriction endonuclease/genetic marker/sex lii

Evidence for DNA modification in the maintenance of X-chromosome i] of adult mouse tissues (Searle's translocationiDNA -mediated cell transformation/hypoxanthine phosphoribosyltransferase)

Mta, a maternally inherited cell surface antigen of the mouse, is transr the egg (embryo transfer/cytotoxic T lymphocytes/bone marrow chin

Genetic instability in Drosophila melanogaster: Deletion induction by i] sequences (chromosome organization/spontaneous deletions/cytogen mapping)

IMMUNOLOGY

Somatic cell parasitism and the evolution of somatic tissue compatibilit (chimera/Dictyostelium mucoroides/frequency-dependent selection/) rejection/self/not-self)

Contribution of zinc and other metals to the biological activity of the se thymic factor (thymus/hormone/peptide/thymulin/chelation)

Monoclonal antibodies to novel myeloid antigens reveal human neutrop heterogeneity (monocytes/myeloid cells/myeloid leukemia/hybridom

Production of immune interferon by an interleukin 2-independent muri line (phorbol 12-myristate 13-acetate/lymphokines)

Protection against syngeneic lymphoma by a long-lived cytotoxic T-cell '(immunotherapy/lymphocyte migration/interleukin 2/Abelson virusl

Isolation and identification of a biologically active peptide derived from .domain of human IgGI (Fc fragment/polyclonal antibody response/ immunoregulation)

Immunological castration of male mice by a totally synthetic vaccine administered in saline (synthetic immunoactivator/immunological h neutralization/luteinizing hormone-releasing hormone/adjuvant-cor hormonal vaccine)

A small hypervariable segment in the variable domain of an immunog] light chain stimulates formation of anti-idiotypic suppressor T cells delayed-type hypersensitivity/monoclonal antibody/A light chain/sol mutation)

MEDICAL SCIENCES

Autoantibodies occurring in two different rheumatic diseases react witl nuclear ribonucleoprotein particle (Sm antigen/electroblot transfer/ lupus erythematosus/mixed connective tissue disease)

iv

,ing/ L. Sanders Haigh, B. Blanchard 5332-5336 Owens, S. Hellewell, and

' V. M. Ingram

y Leo W. Buss 5337-5341 'usion-

I iteration/ Seymour Fogeland Juliet W. Welch 5342-5346

herichia Kazuo Yamaguchi, Mitsuyo 5347-5351 Yamaguchi, and Jun-ichi Tomizawa

human X David Page,-Berengere De Martinville, 5352-5356 'kage) David Barker, Arlene Wyman, Ray

White, Uta Francke, and David Botstein

lactivation V. M. Chapman, P. G. Kratzer, L. D. 5357-5361 Siracusa,. B. A. Quarantillo, R. Evans, and R. M. Liskay

nitted in Kirsten Fischer Lindahl and 5362-5366 eras) Kurt Burki

isertion M. M. Green 5367-5369 'tic

y Leo W. Buss 5337-5341 'usion-

rum Mireille Dardenne, Jean-Marie Ple6au, 5370-5373 Bernadette Nabarra, Pierre Lefrancier, Marcel Derrien, Jean Choay, and Jean-Frangois Bach

hil Edward D. Ball, Robert F. Graziano, 5374-5378 a) Li Shen, and Michael W. Fanger ne T cell William R. Benjamin, Patricia S. 5379-5383

Steeg, and John J. Farrar

clone Morris 0. Dailey, Eric Pillemer, and 5384-5387 Irving L. Weissman

the CH3 Edward L. Morgan, Tony E. Hugli, and 5388-5391 William 0. Weigle

C. Carelli, F. Audibert, J. Gaillard, and 5392-5395 ormone L. Chedid jugated

obulin Nobuo Sakato, Masanori Semma, 5396-5400 (idiotype/ Herman N. Eisen, and natic Takachika Azuma

L the same Angeline S. Douvas 5401-5405 ;ystemic

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Contents

Metabolic fuel and amino acid transport into the brain in experimental mellitus (glucose metabolism/streptozotocin/brain capillary metaboi endothelial cells)

Specific induction of erythroleukemia and myelogenous leukemia in Sprague-Dawley rats (N-nitroso-N-methylurea/7,8,12-trimethyl- benz[a]anthracene/mammary carcinoma/ear duct carcinoma)

Periportal and pericentral pyridine nucleotide fluorescence from the su perfused liver: Evaluation of the hypothesis that chronic treatment ethanol produces pericentral hypoxia (lobular oxygen gradientlethaJ toxicity/liver injury/tissue oxygen tension/tissue NADH fluorescenc

Circulating human mammary epithelial antigens in breast cancer (hun fat globule/radioimmunoassay/tumor marker/monoclonal antibody

Viral etiology of juvenile- and adult-onset squamous papilloma of the 1 (human papillomavirus/immunocytochemistry/Southern transfer ar

NEUROBIOLOGY

Post-tetanic potentiation at an identified synapse in Aplysia is correlat Ca2+-activated K+ current in the presynaptic neuron: Evidence for ? accumulation (synaptic modulation/voltage clamp)

Isolation and amino acid sequence analysis of a 4,000-dalton dynorphir porcine pituitary (opioid/peptide/endorphin/neuropeptide/prohorm,

PHYSIOLOGICAL SCIENCES

Redistribution of amylase activity accompanying its secretion by the p< (enteropancreatic circulation of digestive enzymes/endocrine secretio digestive enzymes/salivary glands)

Corrections

BIOCHEMISTRY

Intracellular receptor for somatostatin in gastric mucosal cells: Decomp reconstitution of somatostatin-stimulated phosphoprotein phosphati (somatostin receptor/Sephadex chromatography/histone/[Tyr ]somc '251-labeled on the Tyr/rat)

Thymosin 34: A ubiquitous peptide in rat and mouse tissues (thymus/sj brain/macrophages/HPLC of peptides)

Primary structure of a cytochrome P-450: Coding nucleotide sequence c phenobarbital-inducible cytochrome P-450 cDNA from rat liver (am sequence/gene cloning/recombinant DNA/primer extension method)

v

diabetes Anthony L. McCall, William R. 5406-5410 ism/ Millington, and Richard J. Wurtman

Charles B. Huggins, Lorraine Grand, 5411-5414 and Norifumi Ueda

rface of the Sungchul Ji, John J. Lemasters, 5415-5419 with Vickie Christenson, and aol Ronald G. Thurman

wan milk Roberto L. Ceriani,.Masao Sasaki, 5420-5424 Howard Sussman, William M. Wara, and Edward W. Blank

arynx Phoebe Mounts, Keerti V. Shah, and 5425-5429 alysis) Haskins Kashima

ad with a R. Kretz, E. Shapiro, and E. R. Kandel 5430-5434 i 2+ -a

from Walter Fischli, Avram Goldstein, 5435-5437 me) Michael W. Hunkapiller, and

Leroy E. Hood

increas K. Miyasaka and S. S. Rothman 5438-5442 of

osition and Florence J. Reyl and Miguel J. M. 5443 ises Lewin tostatin

)leen/ Ewald Hannappel, Gen-jun Xu, James 5443 Morgan, James Hempstead, and B. L. Horecker

f Y. Fujii-Kuriyama, Y. Mizukami, 5443 ino acid K. Kawajiri, K. Sogawa, and

M. Muramatsu

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