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Front Matter Source: Proceedings of the National Academy of Sciences of the United States of America, Vol. 79, No. 19, [Part 1: Biological Sciences] (Oct. 1, 1982), pp. i-vi Published by: National Academy of Sciences Stable URL: http://www.jstor.org/stable/12886 . Accessed: 01/05/2014 12:23 Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at . http://www.jstor.org/page/info/about/policies/terms.jsp . JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact [email protected]. . National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access to Proceedings of the National Academy of Sciences of the United States of America. http://www.jstor.org This content downloaded from 130.132.123.28 on Thu, 1 May 2014 12:23:44 PM All use subject to JSTOR Terms and Conditions
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Page 1: [Part 1: Biological Sciences] || Front Matter

Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 79, No. 19, [Part 1: Biological Sciences] (Oct. 1, 1982), pp. i-viPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/12886 .

Accessed: 01/05/2014 12:23

Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at .http://www.jstor.org/page/info/about/policies/terms.jsp

.JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range ofcontent in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new formsof scholarship. For more information about JSTOR, please contact [email protected].

.

National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access toProceedings of the National Academy of Sciences of the United States of America.

http://www.jstor.org

This content downloaded from 130.132.123.28 on Thu, 1 May 2014 12:23:44 PMAll use subject to JSTOR Terms and Conditions

Page 2: [Part 1: Biological Sciences] || Front Matter

Proceedings OF THE

National Academy of Sciences

OF THE UNITED STATES OF AMERICA

October 1982 Volume 79, Number 19 pp. 5753-6108

Table of Contents

AUTHOR INDEX vii-viii

Biological Sciences

BIOCHEMISTRY

Two forms of murine epidermal growth factor: Rapid separation by using reverse- phase HPLC (rapid HPLC purification/iodination/radioimmunoassay)

Chemical mechanisms for cytochrome P-450 oxidation: Spectral and catalytic properties of a manganese-substituted protein (cytochrome P-450 mechanism/metalloporphyrin reconstitution/manganese (V)-oxo complex/olefin epoxidation)

Modulation by calcium of the potassium permeability of dog heart sarcolemmal vesicles (trifluoperazine/quinidine/Na /Ca+ exchange)

Escherichia coli host factor required specifically for the kX174 stage III reaction: In vitro identification and partial purification (Sin factor/anti-kX174 antiserum)

Proximity of the substrate binding site and the heme-iron catalytic site in cytochrome P-450scc (steroid hydroxylation mechanism/cholesterol side-chain cleavage)

Differences in rates of tyrosine aminotransferase deinduction with cyclic AMP and glucocorticoids (enzyme induction/H35 hepatoma cells/RNA synthesis inhibitors)

Calmodulin stimulation of 45Ca2+ transport and protein phosphorylation in cholinergic synaptic vesicles (Torpedo californica/electric organ/protein kinase/[y-32P]ATP)

Antony W. Burgess, Jaromir Knesel, Lindsay G. Sparrow, Nicos A. Nicola, and Edouard C. Nice

Michael H. Gelb, William A. Toscano, Jr., and Stephen G. Sligar

P. Caroni and E. Carafoli

Ruth Wolfson and Shlomo Eisenberg

Joel J. Sheets and Larry E. Vickery

Elaine J. Lewis, Patrick Calie, and Wesley D. Wicks

Ada Rephaeli and Stanley M. Parsons

5753-5757

5758-5762

5763-5767

5768-5772

5773-5777

5778-5782

5783-5787

i

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Page 3: [Part 1: Biological Sciences] || Front Matter

Complete amino acid sequence and glycosylation sites of glycoprotein gp71A of Friend murine leukemia virus (surface antigen/preparation of glycoprotein/ dansylcysteine determination/"hot spot" for recombination)

Complete nucleotide sequence of the attenuated poliovirus Sabin 1 strain genome (vaccine strain of poliovirus/molecular cloning/genome sequence/ mutation sites)

Use of recombinant DNA technology to program eukaryotic cells to synthesize rat proinsulin: A rapid expression assay for cloned genes (rat preproinsulin/ eukaryotic DNA expression vector)

Escherichia coli single-strand binding protein organizes single-stranded DNA in nucleosome-like units (electron microscopy/nuclease digestion/nucleosomal structure)

Isolation and function of spinach leaf j-ketoacyl-[acyl-carrier-protein] synthases (plant fatty acid biosynthesis/cerulenin inhibition)

An amber suppressor tRNA gene derived by site-specific mutagenesis: Cloning and function in mammalian cells (Xenopus laevis tyrosine tRNA gene/ mammalian cell suppressor/adenovirus 2-simian virus 40 hybrid/ M13 cloning/in vitro suppression)

Nucleotide sequence of tobacco mosaic virus RNA (oligonucleotide primers/cDNA library/RNA polymorphism/eukaryotic ribosome binding/leaky amber termination)

A genetic locus regulates the expression of tissue-specific mRNAs from multiple transcription units (endogenous retroviral gene/GIX phenotype/gp70/RNA blot hybridization/transcriptional control)

Biosynthesis of aromatic compounds: 13C NMR spectroscopy of whole Escherichia coli cells (3-deoxy-D-arabino-heptulosonate-7-phosphate synthase/plasmid/ enzyme overproduction/feedback inhibition/transient trehalose accumulation)

Mechanism of tobacco mosaic virus assembly: Role of subunit and larger aggregate protein (RNA-protein interaction/cucumber green mottle mosaic virus/virus encapsidation)

Site-specific DNA condensation and pairing mediated by the int protein of bacteriophage A (integrative recombination/DNA-protein interaction/ nucleosome/electron microscopy)

Transcription initiation by RNA polymerase II is inhibited by S-adenosylhomocysteine (in vitro transcription/cap formation/ initiation complex)

Molecular cloning of mRNA sequences for cardiac a- and 8-form myosin heavy chains: Expression in ventricles of normal, hypothyroid, and thyrotoxic rabbits (DNA sequence analysis/nuclease S1 mapping/propylthiouracil/thyroxine)

Structure of the mitochondrial F1 ATPase at 9-A resolution (x-ray diffraction/ electron microscopy/subunit arrangement)

Conjugation of ubiquitin to denatured hemoglobin is proportional to the rate of hemoglobin degradation in HeLa cells (erythrocyte ghost fusion/ ATP-dependent proteolysis)

Enhancement of membrane-fusing activity of Sendai virus by exposure of the virus to basic pH is correlated with a conformational change in the fusion protein (paramyxovirus/cell fusion/hemolysis/virus penetration/circular dichroism)

Platelet-derived growth factor binds specifically to receptors on vascular smooth muscle cells and the binding becomes nondissociable (growth factor endocystosis)

'0 isotope shift in 15N NMR analysis of biological N-oxidations: H20-NO2- exchange in the ammonia-oxidizing bacterium Nitrosomonas (hydroxylamine/ nitrite/oxygen exchange)

Messenger RNA species partially in a repressed state in mouse sarcoma ascites cells (messenger ribonucleoprotein particles/translational control/rates of initiation/ribosome packing/cloned cDNAs)

Instability of coated vesicles in concentrated sucrose solutions (clathrin/ preparation of coated vesicles/membrane fluorescent probe/reassociation of coated vesicles)

Robert Chen

Akio Nomoto, Toshiko Omata, Haruka Toyoda, Shusuke Kuge, Hitoshi Horie, Yutaka Kataoka, Yuko Genba, Yasuko Nakano, and Nobumasa Imura

Peter T. Lomedico

Susan Chrysogelos and Jack Griffith

Takashi Shimakata and Paul K. Stumpf

Frank A. Laski, Ramamoorthy Belagaje, Uttam L. RajBhandary, and Phillip A. Sharp

P. Goelet, G. P. Lomonossoff, P. J. G. Butler, M. E. Akam, M. J. Gait, and J. Karn

David E. Levy, Richard A. Lerner, and Michael C. Wilson

Takashi Ogino, Craig Garner, John L. Markley, and Klaus M. Herrmann

Megumi Fukuda and Yoshimi Okada

Marc Better, Chi Lu, Robley C. Williams, and Harrison Echols

Richard Jove and James L. Manley

A. M. Sinha, P. K. Umeda, C. J. Kavinsky, C. Rajamanickam, H.-J. Hsu, S. Jakovcic, and M. Rabinowitz

L. M. Amzel, M. McKinney, P. Narayanan, and Peter L. Pedersen

D. T. Chin, L. Kuehl, and M. Rechsteiner

Ming-chu Hsu, Andreas Scheid, and Purnell W. Choppin

Lewis T. Williams, Patrice Tremble, and Harry N. Antoniades

Kristoffer K. Andersson, Stephen B. Philson, and Alan B. Hooper

Richard Yenofsky, Ingrid Bergmann, and George Brawerman

P. K. Nandi, G. Irace, P. P. Van Jaarsveld, R. E. Lippoldt, and H. Edelhoch

ii

Contents

5788-5792

5793-5797

5798-5802

5803-5807

5808-5812

5813-5817

5818-5822

5823-5827

5828-5832

5833-5836

5837-5841

5842-5846

5847-5851

5852-5856

5857-5861

5862-5866

5867-5870

5871-5875

5876-5880

5881-5885

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Page 4: [Part 1: Biological Sciences] || Front Matter

Contents.

Translational block to. expression of the Escherichia coli Tn9-derived chloramphenicol-resistance gene in Bacillus subtilis (heterologous expression/ gene fusion/chloramphenicol acetyltransferase)

BIOPHYSICS

Structural variability of tRNA: Small-angle x-ray scattering of the yeast tRNAPhe-Escherichia coli tRNAG'U complex (anticodon interaction/ electron-pair distance distribution/solution structure)

DNA motions in the nucleosome core particle (triplet state anisotropy decay/ methylere blue/tetrabromorhodamine 123)

CELL BIOLOGY

Molecular structure and evolutionary origin of human cardiac muscle actin gene (recombinant DNA/DNA sequence/intron location/gene family/stretched poly[d(T-G)]sequence)

Chemoattractant receptor functions in human polymorphonuclear leukocytes are divergently altered by membrane fluidizers (chemotaxis/fMet-Leu-Phe receptor/n-butanol)

Nonrandom distribution of repeated'DNA sequences with respect to supercoiled loops and the nuclear matrix (satellite DNA/DNA organization/chromatin)

Repeat array in Epstein-Barr virus DNA is related to cell DNA sequences interspersed on human chromosomes (cytological hybridization/Southern blot analysis/repetitive DNA/DNA.DNA hybridization).

Internalized insulin receptors are recycled to the cell surface in rat hepatocytes (photoaffinity labeling/electron microscopic autoradiography/receptor. subunits)

Mapping the mitochondrial DNA of Zea mays: Ribosomal gene localization (mitochondrial rRNAs/restriction enzymes/hybridization/clone)

Purification of a prolactin receptor (lactogenic hormones/mouse liver microsomes/ zwitterionic detergent/affinity chromatography)

Ricin inhibition of in vitro protein synthesis by plant ribosomes (Ricinus. communis agglutinin/castor bean/wheat germ)

On the nature of crossreactions observed with antibodies directed to defined epitopes (anti-peptide antibodies/monoclonal 'antibodies/immunofluorescence)

DEVELOPMENTAL BIOLOGY

Message-specific sequestration of maternal histone mRNA in the sea urchin egg (intracellular localization/translational control)

EVOLUTION

Mapping evolution with ribosome structure: Intralineage constancy and interlineage variation (archaebacterial bill/eukaryotic lobes/unrooted dendrogram/endokaryotic hypothesis)

Immunological similarity between a cyanobacterial enzyme and a nuclear DNA- encoded plastid-specific isozyme from spinach (cell evolution/chloroplast isozymes/endosymbiosis/enzyme-linked immunosorbent assay/ glucosephosphate isomerase)

GENETICS

A processed human immunoglobulin e gene has moved to chromosome 9 (pseudogene/human IgE/chromosome mapping)'

Mismatch repair, gene conversion, and crossing-over in two recombination- defective mutants of Drosophila melanogaster(meiotic mutant/rosy locus/ postmeiotic segregation/recombination models/heteroduplex DNA)

David S. Goldfarb, Raymond L. Rodriguez, and Roy H. Doi

Lennart Nilsson, Rudolf Rigler, and Peter Laggner

J. Wang, M. Hogan, and R. H. Austin

Hiroshi Hamada, Marianne G. Petrino, and Takeo Kakunaga

Itzhak Yuli, Akimitsu Tomonaga, and Ralph Snyderman

Don Small, Barry Nelkin, and Bert Vogelstein

Mark Heller, Ann Henderson, and Elliott Kieff

Max Fehlmann, Jean-Louis Carpentier, Emmanuel Van Obberghen, Pierre Freychet, Peter Thamm, Derek Saunders, Dietrich Brandenburg, and Lelio Orci

Keith P. Iams and John H. Sinclair

Daniel.S. Liscia and Barbara K. Vonderhaar

Suzanne M. Harley and Harry Beevers

E.'A. Nigg, G. Walter, and S. J. Singer

Richard M. Showman; Dan E. Wells, John Anstrom, Deborah A. Hursh, and Rudolf A. Raff

James A. Lake, Eric Henderson, Michael W. Clark, and A. T. Matheson

Norman F. Weeden, Ratchford C. Higgins, and L. D. Gottlieb

5886-5890

5891-5895

5896-5900

5901-5905

5906 5910

5911-5915

5916-5920

5921-5925

5926-5929

5930-5934'

5935-5938

5939-5943'

5944-5947

5948-5952

5953-5955

James Battey, Edward E. Max, Wesley. 5956-5960 0. McBride, David Swan, and Philip. Leder

Adelaide T. C. Carpenter - 5961-5965.

iii

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Page 5: [Part 1: Biological Sciences] || Front Matter

Contents

Isolation of a cDNA clone for the human HLA-DR antigen a chain by using a synthetic oligonucleotide as a hybridization probe (B-cell histocompatibility antigen/restriction fragment polymorphism)

SOS chromotest, a direct assay of induction of an SOS function in Escherichia coli K-12 to measure genotoxicity (Salmonella mutatest/phage inductest/ carcinogen tests)

Clustering of spore-specific genes in Aspergillus nidulans (gene organization/gene expression/fungi/conidia)

Orientation of cohesive end site cos determines the active orientation of X sequence in stimulating recA.recBC-mediated recombination in phage A lytic infections (in vitro mutagenesis/cos mutant/phage packaging/phage DNA injection/Tn5)

Encapsidation sequences for spleen necrosis virus, an avian retrovirus, are between the 5' long terminal repeat and the start of the gag gene (packaging/ splicing/retrovirus vector)

Tissue-specific regulation of gene function: Presetting and erasure (P locus/ modulator/variegation pericarp/transposition)

IMMUNOLOGY

Recent duplication and germ-line diversification of rat immunoglobulin K chain gene joining segments (Ig gene evolution/unequal crossing-over/antibody diversity/DNA sequencing)

Biochemical separation of ahuman B cell mitogenic factor (lymphokines/ lymphocyte growth factors/proliferation/differentiation)

Inhibition of in vitro natural killer activity by the third component of complement: Role for the C3a fragment (spontaneous cytotoxicity/regulation/ complement/structure-function)

Three distinct stages of B-cell defects in common varied immunodeficiency (Staphylococcus and anti-IgM mitogenicity/pokeweed mitogen/ immunoglobulin secretion)

The amino acid sequence and gene organization of the heavy chain of the HLA- DR antigen: Homology to immunoglobulins (major histocompatibility complex/Ig-like domain)

Heavy chain genes of rabbit IgG: Isolation of a cDNA encoding y heavy chain and identification of two genomic C, genes (allotype/nucleotide sequence/ recombinant phage DNA library)

Deborah Stetler, Hriday Das, Jack H. Nunberg, Randall Saiki, Rosy Sheng-Dong, Kary B. Mullis, Sherman M. Weissman, and Henry A. Erlich

Philippe Quillardet, Olivier Huisman, Richard D'Ari, and Maurice Hofnung

William C. Orr and William E. Timberlake

Ichizo Kobayashi, Helios Murialdo, Jean M. Crasemann, Mary M. Stahl, and Franklin W. Stahl

Shinichi Watanabe and Howard M. Temin

Drew Schwartz

Yigal Burstein, Aviva V. Breiner, Curtis R. Brandt, Christine Milcarek, Raymond W. Sweet, Ditsa Warszawski, Etti Ziv, and Israel Schechter

Abby Maizel, Chintaman Sahasrabuddhe, Shashikant Mehta, John Morgan, Lawrence Lachman, and Richard Ford

Christiane Charriaut, Anna Senik, Jean-Pierre Kolb, Monique Barel, and Raymond Frade

Osamu Saiki, Peter Ralph, Charlotte Cunningham-Rundles, and Robert A. Good

Alan J. Korman, Charles Auffray, Anton Schamboeck, and Jack L. Strominger

Christine L. Martens, Kevin W. Moore, Michael Steinmetz, Leroy Hood, and Katherine L. Knight

MEDICAL SCIENCES

Mortality among health-conscious elderly Californians (epidemiology/vitamin supplements/vitamin E)

a-Difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits tumor promoter-induced polyamine accumulation and carcinogenesis in mouse skin (putrescine/decarboxylation inhibitor/stage-specific promotion/ tumorigenesis/phorbol diester)

Transepithelial transport by pulmonary alveolar type II cells in primary culture (sodium transport/pulmonary edema)

Glanzmann thrombasthenia: Deficient binding of von Willebrand factor to thrombin-stimulated platelets (glycoprotein/receptor/bleeding disorder/ ristocetin cofactor)

Stimulation of leukotriene biosynthesis in human blood leukocytes by platelet- derived 12-hydroperoxyicosatetraenoic acid (arachidonic acid/lipoxygenase/ prostaglandins/inflammation)

James E. Enstrom and'Linus Pauling

C. E. Weeks, A. L. Herrmann, F. R. Nelson, and T. J. Slaga

Robert J. Mason, Mary C. Williams, Jonathan H. Widdicombe, Martin J. Sanders, Dayton S. Misfeldt, and Leonard C. Berry, Jr.

Zaverio M. Ruggeri, Rossella Bader, and Luigi de Marco

Jacques Maclouf, Bernard Fruteau de Laclos, and Pierre Borgeat

iv

5966-5970

5971-5975

5976-5980

5981-5985

5986-5990

5991-5992

5993-5997

5998-6002

6003-6007

6008-6012

6013-6017

6018-6022

6023-6027

6028-6032

6033-6037

6038-6041

6042-6046

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Page 6: [Part 1: Biological Sciences] || Front Matter

Contents

Reconstitution after transplantation with T-lymphocyte-depleted HLA haplotype- mismatched bone marrow for severe combined immunodeficiency (monoclonal antibody/chimerism/tolerance/alloreactivity/differentiation)

A single domain of human prostatic acid phosphatase shows antibody-mediated restoration of catalytic activity (limited proteolysis/active site/antibody- mediated restoration)

Similarity of secretory protein I from parathyroid gland to chromogranin A from adrenal medulla (secretion/parathormone/epinephrine/chromaffin granule)

Post-translational processing of cholecystokinin in pig brain and gut (methanol extraction/acid extraction/high-performance liquid chromatography/ Sephadex gel filtration)

MICROBIOLOGY

Cloning and localization of the lepidopteran protoxin gene of Bacillus thuringiensis subsp. kurstaki (larval toxin/antigen/plasmid/ chromosomal DNA)

NEUROBIOLOGY

Brain transglutaminase: In vitro crosslinking of human neurofilament proteins into insoluble polymers [e-(y-glutamyl)lysine/isopeptide crosslinks/brain filaments/aging brain/Alzheimer disease]

Regulation of phosphorylation of proteins I, IIIa, and IIIb in rat neurohypophysis in vitro by electrical stimulation and by neuroactive agents (calcium/cAMP/ dopamine/fluphenazine)

Sprouting from chicken embryo dorsal root ganglia induced by nerve growth factor is specifically inhibited by affinity-purified antiganglioside antibodies (gangliosides)

Isolation, characterization, and purification to homogeneity of a rat brain protein (GABA-modulin) (benzodiazepines/transmitter receptors)

Monoclonal antibodies recognize individual neurofilament triplet proteins (intermediate filaments/unique and shared antigenic determinants)

Role of prostaglandin D2 in the hypothermia of rats caused by bacterial lipopolysaccharide (body temperature/prostaglandins/intracerebral injection/ indomethacin/radioimmunoassay)

Thalamic inputs to cytochrome oxidase-rich regions in monkey visual cortex (lateral geniculate body/striate cortex/area 18/2-deoxyglucose)

PHYSIOLOGICAL SCIENCES

Sleep-promoting effects of muramyl peptides

Corrections

BIOCHEMISTRY

Role of positive charge on the amino-terminal region of the signal peptide in protein secretion across the membrane (loop model/site-specific mutagenesis/ synthetic oligonucleotide/lipoprotein/outer membrane)

Amino acid sequence of mouse submaxillary gland renin (homology with pepsin/ active site)

GENETICS

Mitochondrial DNA polymorphism in a maternal lineage of Holstein cows (nucleotide sequence/cytoplasmic inheritance/silent mutation)

Ellis L. Reinherz, Raif Geha, Joel; M. Rappeport, Marjorie Wilson, Ann C. Penta, Rebecca E. Hussey, Kathleen A. Fitzgerald, John F. Daley, Herbert Levine, Fred S. Rosen, and Stuart F. Schlossman

B. K. Choe, M. K. Dong, D. Walz, S. Gleason, and N. R. Rose

D. V. Cohn, R. Zangerle, R. Fischer- Colbrie, L. L. H. Chu, J. J. Elting, J. W. Hamilton, and H. Winkler

John Eng, Yoshiharu Shiina, Eugene Straus, and Rosalyn S. Yalow

Gary A. Held, Lee A. Bulla, Jr., Eugenio Ferrari, James Hoch, Arthur I. Aronson, and Scott A. Minnich

Dennis J. Selkoe, Carmela Abraham, and Yasuo Ihara

Kang Tsuo and Paul Greengard

M. Schwartz and N. Spirman

A. Guidotti, D. R. Konkel, B. Ebstein, M. G. Corda, B. C. Wise, H. Krutzsch, J. L. Meek, and E. Costa

V. Lee, H. L. Wu, and W. W. Schlaepfer

Ryuji Ueno, Shuh Narumiya, Toshiya Ogorochi, Teruo Nakayama, Youzou Ishikawa, and Osamu Hayaishi

Margaret S. Livingstone and David H. Hubel

J. M. Krueger, J. R. Pappenheimer, and M. L. Karnovsky

Sumiko Inouye, Xavier Soberon, Thomas Francechini, Kenzo. Nakamura, Keiichi Itakura, and Masayori Inouye

Kunio S. Misono, Jin-Jyi Chang, and Tadashi Inagami

William W. Hauswirth and Philip J.. Laipis

v

6047-6051

6052-6055

6056-6059

6060-6064

6065-6069

6070-6074

6075-6079

6080-6083

6084-6088

6089-6092

6093-6097

6098-6101

6102-6106

6107

6107

6107

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Page 7: [Part 1: Biological Sciences] || Front Matter

Contents

IMMUNOLOGY

Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions (major histocompatibility complex gene products/cytotoxicity/ monoclonal antibodies)

Stefan C. Meuer, Stuart F. Schlossman, and Ellis L. Reinherz

vi

6107

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