Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 80, No. 18, [Part 1: Biological Sciences] (Sep. 15, 1983), pp. i-vPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/14356 .

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'ro~ceedins OF THE

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September 1983 Volume 80, Number 18 pp. 5455-5806

Table of Contents

AUTHOR INDEX vii-viii

Biological Sciences

BIOCHEMISTRY

Multiple steady states and oscillatory behavior of a compartmentalized J. F. Hervagault, M. C. Duban, J. P. 5455-5459 phosphofructokinase system (hysteresisltransitions) Kernevez, and D. Thomas

Heparin-catalyzed inhibitor/protease reactions: Kinetic evidence for a common Michael J. Griffith 5460-5464 mechanism of action of heparin (antithrombin IIIIheparin cofactor III thrombinPfactor Xa)

Nucleotide sequence and expression of human chromosome 21-encoded superoxide Levana Sherman, Naomi Dafni, Judy 5465-5469 dismutase mRNA (Down syndrome/SOD-1 mRNA specieslgene closage) Lieman-Hurwitz, and Yoram Groner

Asparaginylglucose: Novel type of carbohydrate linkage (archaebacterialcell Felix Wieland, Renate Heitzer, and 5470-5474 surface glycoprotein) Wolfram Schaefer

Primary structure of streptococcal Pep M5 protein: Absence of extensive sequence Belur N. Manjula, Sheenah M. Mische, 5475-5479 repeats (seven-residue periodicitylcoiled-coil structurelantiphagocytic effect) and Vincent A. Fischetti

F sex factor encodes a single-stranded DNA binding protein (SSB) with extensive John W. Chase, Barbara M. Merrill, 5480-5484 sequence homology to Escherichia coli SSB (DNA and protein sequencesl and Kenneth R. Williams functional domainslsecondary structureaevolution)

Septmbea pnr ea 1983glcao Votishe lumao-ela80, Numertde 18 nd pp.pz,MrhaL rair 5455-54806

5Multiplcyoie stayitts loanizd oscillatoory s behavirot compatmentaizto eH DNDoth J. F.Hraault, M.vi C. Duban, J.nP 5455-54594

Heprnctalyzedtion/hibior/protgease exreactions:ig Koineictvdec froru a comotens Michael J. Garifita46-56

thrombn/factora Xogaph)

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Contents

Synthesis and post-translational assembly of intermediate filaments in avian Randall T. Moon and Elias Lazarides 5495-5499 erythroid cells: Vimentin assembly limits the rate of synemin assembly (immunoprecipitation/phosphorylation/protein assembly/cytoskeleton)

Release of initiation control by a mutational alteration in the R6K 7r protein David M. Stalker, Marcin Filutowicz, 5500-5504 required for plasmid DNA replication (antibiotic resistance/negative replication and Donald R. Helinski control/nucleotide sequence/initiation protein/amino acid substitution)

Transcribed chromatin exhibits an altered nucleosomal spacing (micrococcal Richard D. Smith, Ronald L. Seale, 5505-5509 nuclease digestion/nucleosomal repeat lengths/chromatin structure) and John Yu

Nucleotide-stimulated proteolysis of histone Hi [protease/P1,P4-di(adenosine-5') Carol S. Surowy and Nathan A. Berger 5510-5514 tetraphosphate/ATP/pyrophosphate/human lymphocytes]

Inducible transcription of five globin genes in K562 human leukemia cells Ann Dean, Timothy J. Ley, R. Keith 5515-5519 (human globin mRNA/in vitro translation/S1 nuclease mapping/gene Humphries, Michael Fordis, and expression/8-globin mRNA) Alan N. Schechter

Complete primary structures of the E,8 chain and gene of the mouse major Haruo Saito, Richard A. Maki, Linda 5520-5524 histocompatibility complex (major histocompatibility complex I-E molecule/ K. Clayton, and Susumu Tonegawa exon-intron/control of gene expression/cDNA/cloning)

Specific high-affinity binding and biologic action of retinoic acid in human Mark Haussler, Neil Sidell, Michael 5525-5529 neuroblastoma cell lines (vitamin A/cellular retinoic acid binding protein/ Kelly, Carol Donaldson, Adrienne cell proliferation/cell differentiation) Altman, and David Mangelsdorf

A mutation in the Escherichia coli rho gene that inhibits the N protein activity of Asis Das, Max E. Gottesman, Judith 5530-5534 phage A (transcription termination/nus mutations) Wardwell, Patsy Trisler, and

Susan Gottesman

Identification of the polypeptides encoded in the ATPase 6 gene and in the Anne Chomyn, Paolo Mariottini, 5535-5539 unassigned reading frames 1 and 3 of human mtDNA (Hela cells/synthetic Nestor Gonzalez-Cadavid, Giuseppe peptides/antibodies/mitochondrial translation products) Attardi, Donna D. Strong, Dennis

Trovato, Marcia Riley, and Russell F. Doolittle

Termination sites of the in vitro nick-translation reaction on DNA that had Jacques G. Piette and John E. Hearst 5540-5544 photoreacted with psoralen (Escherichia coli DNA polymerase I/bacteriophage OX174/DNA sequence analysis/bypass replication/kinetic attenuators)

Slow cruciform transitions in palindromic DNA (DNA supercoiling/self- Martin Gellert, Mary H. O'Dea, and 5545-5549 complementary DNA/hairpins) Kiyoshi Mizuuchi

Isolation of Z-DNA-containing plasmids (monoclonal antibody/recombinant Ralf Thomae, Stephan Beck, and Fritz 5550-5553 Escherichia coli DNA/affinity chromatography) M. Pohl

Isolation of the nitrogen assimilation regulator NRI, the product of the glnG gene Lawrence J. Reitzer and Boris 5554-5558 of Escherichia coli (nitrogen regulation/transcription in vitro/glnL promoter) Magasanik

Two DNA methyltransferases from murine erythroleukemia cells: Purification, Timothy H. Bestor and Vernon 5559-5563 sequence specificity, and mode of interaction with DNA (facilitated transfer) M. Ingram

Identification of a single transcriptional initiation site for the glutamic tRNA and Thomas Christianson, John C. 5564-5568 COB genes in yeast mitochondria (Saccharomyces cerevisiae/ Edwards, David M. Mueller, and guanylyltransferase/in vitro capping/in vitro transcription/cytochrome b) Murray Rabinowitz

BIOPHYSICS

Normal mode paths for hydrogen exchange in the peptide ferrichrome (peptide Robert P. Sheridan, Ronald M. Levy, 5569-5572 surface accessibility/atomic fluctuations) and S. W. Englander

CELL BIOLOGY

Flow cytometric measurement of total DNA content and incorporated F. Dolbeare, H. Gratzner, M. G. 5573-5577 bromodeoxyuridine (DNA synthesis/cell cycle/1-,3-D-arabinofuranosylcytosine/ Pallavicini, and J. W. Gray monoclonal antibody)

Dephosphorylation of a major sperm membrane protein is induced by egg jelly Gary E. Ward and Victor D. Vacquier 5578-5582 during sea urchin fertilization (Arbacia punctulata/sperm activation/sperm phosphoproteins/flagellar proteins)

1la,25-Dihydroxyvitamin D3 promotes fusion of mouse alveolar macrophages both Etsuko Abe, Chisato Miyaura, 5583-5587 by a direct mechanism and by a spleen cell-mediated indirect mechanism (cell Hirofumi Tanaka, Yoshiko Shiina, fusion/lymphoki ne/vitamin D3/concanavalin A/phytohemagglutinin) Takeo Kuribayashi, Satoshi Suda,

Yasuho Nishii, Hector F. DeLuca, and Tatsuo Suda

Molecular cloning and cell cycle-specific regulation of a functional human Harvey D. Bradshaw, Jr. 5588-5591 thymidine kinase gene (gene rescue/DNA -mediated transformation/ cell synchronization)

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Contents

Surface binding and internalization of platelet-derived growth factor in human Jan Nilsson, Johan Thyberg, Carl- 5592-5596 fibroblasts (cell culture/endocytosis/electron microscopic autoradiography/ Henrik Heldin, Bengt Westermark, indirect immunofluorescence) and Ake Wasteson

Control of H-2 antigen and /32-microglobulin gene expression in mouse trophoblast Kenichi Tanaka, Keiko Ozato, Gilbert 5597-5601 cell clones (histocompatibility antigen/flow microfluorometryl Jay, Jane R. Parnes, Lata teratocarcinoma/endodermal cells) Ramanathan, J. G. Seidman,

Kenneth S. S. Chang, and Ettore Appella

Flat revertants isolated from Kirsten sarcoma virus-transformed cells are Makoto Noda, Zvi Selinger, Edward M. 5602-5606 resistant to the action of specific oncogenes (mouse 3T3 cells/retroviruses/ Scolnick, and Robert H. Bassin ouabain/somatic cell hybridization)

Amphotericin B selection of mutant Chinese hamster cells with defects in the Monty Krieger, Julianna Martin, Mark 5607-5611 receptor-mediated endocytosis of low density lipoprotein and cholesterol Segal, and David Kingsley biosynthesis (polyene antibiotic/receptor-dependent killing/ cholesterol auxotrophs)

Chromatid damage after G2 phase x-irradiation of cells from cancer-prone Ram Parshad, Katherine K. Sanford, 5612-5616 individuals implicates deficiency in DNA repair (chromatid gaps and breaks) and Gary M. Jones

Formation of receptosomes from plasma membrane coated pits during endocytosis: Mark C. Willingham and Ira Pastan 5617-5621 Analysis by serial sections with improved membrane labeling and preservation techniques (clathrin-coated pits/coated vesicles/concanavalin A/ horseradish peroxidase/receptor-mediated endocytosis)

Cell growth on liquid interfaces: Role of surface active compounds (protein Charles R. Keese and Ivar Giaever 5622-5626 adsorption at interfaces/fluorocarbon and silicone fluid substrates/liquid microcarriers)

Antibodies to the epidermal growth factor receptor block the biological activities Graham Carpenter, Christa M. 5627-5630 of sarcoma growth factor (growth factors/transformation/protein kinase) Stoscheck, Yvette A. Preston, and

Joseph E. DeLarco Luteinizing hormone receptor appearance in cultured porcine granulosa cells Deborah L. Segaloff and Lee 5631-5635

requires continual presence of follicle-stimulating hormone (hormone action/ E. Limbird ovary/cAMP)

Rapid selective effects by a growth inhibitor and epidermal growth factor on the Marit Nilsen-Hamilton and Robert 5636-5640 incorporation of [35S]methionine into proteins secreted by African green W. Holley monkey (BSC-1) cells (inhibitor-inducible protein/kidney epithelial cell growth inhibitor/mitogen-induced proteins/secreted glycoprotein)

DEVELOPMENTAL BIOLOGY

Early differential tissue expression of transposon-like repetitive DNA sequences Philippe Bruilet, Mourad Kaghad, Yi- 5641-5645 of the mouse (retrovirus/embryonal carcinoma/differentiation) Sheng Xu, Odile Croissant, and

Francois Jacob Thermotaxis of Dictyostelium discoideum amoebae and its possible role in Choo B. Hong, Donna R. Fontana, and 5646-5649

pseudoplasmodial thermotaxis (temperature/sensory transduction/slime mold) Kenneth L. Poff Direct evidence for interaction between human erythroid progenitor cells and a G. Stamatoyannopoulos, B. Nakamoto, 5650-5654

hemoglobin switching activity present in fetal sheep serum (environment-cell S. Kurachi, and Th. interaction/humoral factor) Papayannopoulou

GENETICS

Human chromosome 13 compensates a DNA repair defect in UV-sensitive mouse Tada-aki Hori, Tadahiro Shiomi, and 5655-5659 cells by mouse-human cell hybridization (human gene mapping/UV Koki Sato sensitivity/somatic cell hybrids)

New approaches for computer analysis of nucleic acid sequences (dyad Samuel Karlin, Ghassan Ghandour, 5660-5664 symmetries/homology/self-dyad/algorithm) Friedemann Ost, Simon Tavare, and

Laurence J. Korn One of two Epstein-Barr virus nuclear antigens contains a glycine-alanine Kevin Hennessy and Elliott Kieff 5665-5669

copolymer domain (gene fusion/f3-galactosidase) Pre-crisis mouse cells show strain-specific covariation in the amount of 54- Suzie Chen, George Blanck, and Robert 5670-5674

kilodalton phosphoprotein and in susceptibility to transformation by E. Pollack simian virus 40 (somatic variation/establishment/tumor antigen/ oncogenic- susceptibility/oncogenesis)

Recombination between sequences in nonhomologous positions (chromosome Neal Sugawara and Jack W. Szostak 5675-5679 rearrangements/translocations/gene conversion/ri bosomal DNA)

Isolation and characterization of the RAD3 gene of Saccharomyces cerevisiae and David R. Higgins, Satya Prakash, Paul 5680-5684 inviability of rad3 deletion mutants (DNA repair/excision/pyrimidine dimers/ Reynolds, Renata Polakowska, DNA crosslinks/cloning) Shane Weber, and l.ouise Prakash

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Contents

Sensory distinction between H-2b and H-2bml mutant mice (major K. Yamazaki, G. K. Beauchamp, I. K. 5685-5688 histocompatability complexlY maze/transfer of training/odor Egorov, J. Bard, L. Thomas, and phenotypes/olfaction) E. A. Boyse

IMMUNOLOGY

Partial purification and characterization of an antigen-specific helper factor Ruth Lifshitz, Ron N. Apte, and 5689-5693 synthesized by a T-cell continuous line (antigen-specific factor/helper T-cell Edna Mozes line/synthetic polypeptide/low molecular weight helper fraction)

Identification and initiali characterization of a rat monoclonal antibody reactive Thomas R. Malek, Richard J. Robb, 5694-5698 with the murine interleukin 2 receptor-ligand complex (lymphokine/T and Ethan M. Shevach lymphocyte/hormone-receptor complex)

Identification of the C3bi receptor of human monocytes and macrophages by using Samuel D. Wright, Patricia E. Rao, 5699-5703 monoclonal antibodies (phagocytosis/complement/OKM1). Wesley C. Van Voorhis, Lydia S.

Craigmyle, Kyoko Iida, Mary Anne Talle, Elizabeth F. Westberg, Gideon Goldstein, and Samuel C. Silverstein

RNA transcripts for I-J polypeptides are apparently not encoded between the I-A Mitchell Kronenberg, Michael 5704-5708 and I-E subregions of the murine major histocompatibility complex (RNA blot/ Steinmetz, Joan Kobori, Ellen Kraig, T-cell hybridoma/suppressor cell/I region genetics) Judith A. Kapp, Carl W. Pierce,

Craig M. Sorensen, Gen Suzuki, Tomio Tada, and Leroy Hood

Rabbit immunoglobulin K genes: Structure of a germline b4 allotype J-C locus Laurent Emorine, Kevin Dreher, 5709-5713 and evidence for several b4-related sequences in the rabbit genome (joining Thomas J. Kindt, and Edward region/nucleotide sequence/latent allotype) E. Max

Isolation of cDNA clones for the p33 invariant chain associated with HLA-DR E. 0. Long, M. Strubin, C. T. Wake, 5714-5718 antigens (Ia antigen/protein assembly/oocyte injection/hybrid-selection/ N. Gross, S. Carrel, P. Goodfellow, chromosomal mapping) R. S. Accolla, and B. Mach

Further characterization of HLA-DS molecules: Implications for studies assessing Sanna M. Goyert and Jack Silver 5719-5723 the role of human Ia molecules in cell interactions and disease susceptibility (two-dimensional gel analysis/polymorphism/monoclonal antibodies/ supertypic specificities)

MEDICAL SCIENCES

Specific DNA sequence amplification in human neuroblastoma cells (gene Kate T. Montgomery, June L. Biedler, 5724-5728 amplification/chromosome abnormalities/neuronal malignancy) Barbara A. Spengler, and Peter

W. Melera Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse Allen B. Clarkson, Jr., Cyrus J. Bacchi, 5729-5733

model of central nervous system African trypanosomiasis (polyamines/rational George H. Mellow, Henry C. chemotherapy/sleeping sickness/ornithine decarboxylase) Nathan, Peter P. McCann, and

Albert Sjoerdsma Cycling of peripheral blood and marrow lymphocytes in cyclic neutropenia (pre-B Dan Engelhard, Kenneth S. Landreth, 5734-5738

cellslcyclic.hemopoiesis/regulatory factors) Neena Kapoor, Paul W. Kincade, Lawrence E. De Bault, Alexander Theodore, and Robert A. Good

Cholesterol synthesis and low density lipoprotein uptake are regulated Eduard F. Stange and John 5739-5743 independently in rat small intestinal epithelium (villus cells/crypt cells/low M. Dietschy density. lipoprotein receptor)

Crosslinking of the receptors for immunoglobulin E depolarizes the plasma Baruch I. Kanner and Henry Metzger 5744-5748 membrane of rat basophilic leukemia cells (receptor crosslinking/serotonin release/tetraphenylphosphonium/calcium ions)

Critical role played by thyroid hormone in induction of neoplastic transformation Carmia Borek, Duane L. Guernsey, 5749-5752 by chemical carcinogens in tissue culture (triiodothyronine/N-methyl-N'-nitro- Augustinus Ong, and I. S. Edelman N-nitrosoguanidine/benzo[a]pyrene/cell cultures/protein synthesis)

NEUROBIOLOGY

Primary structure and neuronal effects of aY-bag cell peptide, a second candidate Barry S. Rothman, Earl Mayeri, 5753-5757 neurotransmitter encoded by a single gene in bag cell neurons of Aplysia (high Richard 0. Brown, Pau-Miau Yuan, pressure liquid chromatography/autotransmitter/egg -laying behavior/co- and John E. Shively transmitter/long- term .inhibition)

A surface antigen expressed by a subset of neurons in the vertebrate central Susan Hockfield and Ronald 5758-5761 nervous system (monoclonal antibodies/spinal cord/synaptic D. G. McKay structure/neuro.immunology)

iv

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Contents

Kinetics of homophilic binding by embryonic and adult forms of the neural cell Stanley Hoffman and Gerald 5762-5766 adhesion molecule (cell surface modulation/neural development/binding M. Edelman assay/sialic acid-rich glycoprotein)

Antigenic and structural differences in the catalytic subunits of the molecular B. P. Doctor, Shelley Camp, Mary Kay 5767-5771 forms of acetylcholinesterase (monoclonal antibodies/basal lamina/ Gentry, Susan S. Taylor, and tryptic peptides) Palmer Taylor

Evidence for a proenekphalin-like precursor. in amphibian brain (opioid peptide/ Daniel L. Kilpatrick, Richard D. 5772-5775 prohormone/protein evolution/HPLC) Howells, Hans-Werner Lahm, and

Sidney Udenfriend Shape recognition and inferior temporal neurons (visual cortex/pattern Eric L. Schwartz, Robert Desimone, 5776-5778

recognition/vision/Fourier descriptors/boundary curvature) Thomas D. Albright, and Charles G. Gross

Ultrastructural networks in growth cones and neurites of cultured central Ho-Ching Tiffany Tsui, Hans Ris, and 5779-5783 nervous system neurons (cytoskeleton/synaptic vesicles/filopodia/high-voltage William L. Klein electron microscopy/synapse)

PHYSIOLOGICAL SCIENCES

A flow- and time-dependent index of ischemic injury after experimental coronary Laurence W. V. DeBoer, Robert E. 5784-5788 occlusion and reperfusion (myocardial ischemia/myocardial infarction) Rude, Robert A. Kloner, Joanne S.

Ingwall, Peter R. Maroko, Michael A. Davis, and Eugene Braunwald

POPULATION BIOLOGY

Reexamination of diversifying selection of polymorphic allozyme genes by using Tsuneyuki Yamazaki, S. Kusakabe, H. 5789-5792 population cages in Drosophila melanogaster (neutral theory/ Tachida, M. Ichinose, H. Yoshimaru, allozyme polymorphism) Y. Matsuo, and Terumi Mukai

Correction

EVOLUTION

Modular structural units, exons, and function in chicken lysozyme (module/ Mitiko Go 5793 compact structural unit/origin of intron/protein evolution)

Physical Sciences 5795-5806

v

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