Personalized Nutrition and Health 23rd of November, Food Matters Live, London Nard Clabbers Senior Business Developer Personalized Nutrition and Health TNO Healthy Living

TNO - BETTER WORLD THROUGH

APPLIED RESEARCH

Dutch Applied Research and Technology Organisation

Independent, not for profit

Founded by law (1932)

> 2600 employees

Zeist

Presentation outline

• Three little pigs

• What is health?

• Personalized nutrition 2.0

• Research and real life examples!

• Conclusions

Three little pigs

Marginal diet Marginal diet +

unlimited sugar

Standard diet

1: Both quantity and quality of diet is relevant 2: Fenotypes can differ, even with identical genotypes

A definition of health

• ‘Ability to adapt‘

– Capacity to adapt to live’s many challenges

• ‘Resilience’

• ‘Flexibility’

M. Huber, BMJ 2011

Physiological processes involved in phenotypic flexibility

Genes Nutr (2015), 10:13

Health

Metabolic Physical

Immune

Sleep

Social

Mental/emotional

Behavioral

Cognitive

Gut

Food intake!

Health domains

Personalized Nutrition ‘2.0’

• Fenotype, ‘sociotype’, genotype, environment, culture, personality, food intake,… everything!

• Data driven – Measurements (DIY) of day by day changes

– Bio-psycho-social aspects of health • DNA: sure, also

• PN 2.0 = Empowerment

Pilot study: Personalised advice for healthy muscles

n=60

Questionnaires Motivation Energy Resilience

Waist, arm & thigh circumference

Instruments

Weight & fat percentage

Total cholesterol HDL & LDL Triglycerides

Handgrip strength Short Physical Performance Battery

Chair stand

Balance

Speed

Samples for lab

Fasting & Postprandial glucose Fasting & Postprandial C-peptide Fasting & Postprandial amino acids Fasting fatty acids

Metabolism

DIY tools for muscle health

ACE, TCF7L2, FTO, FADS1, GDF5, VDR

Genetic variation

Food diary

Activity tracker

Muscle your score

Wellbeing your score

Muscle

Wel

lbei

ng

Optimal

Reduced

You

Individual feedback on health

TNO/WUR ‘Personalised Nutrition and Health’ Research Program

For a society in which each individual can and will make a motivated and sustained choice for a healthy diet.

3D PRINTED PERSONALIZED FOOD

Company example: Day Two

Company example: Habit

Two converging megatrends

-Health and wellness

-Digital and tech revolution make PN 2.0 possible

Holistic, consumer centered approach is needed

-Towards health

-Towards science

-Towards business cases

Conclusions

END TNO Stand RP83