PET Imaging of Glutaminolysis in Tumors by18F-(2S,4R)4-Fluoroglutamine

Reporter: Fei Liu

Supervisor: Prof. Zhi Yang

31 March 2014

Mentor: Nan Li and Hua Zhu

Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

Contents:

PET Imaging of Glutaminolysis in Tumors by18F-(2S,4R)4-Fluoroglutamine

Reporter: Fei Liu

Supervisor: Prof. Zhi Yang

31 March 2014

Mentor: Nan Li and Hua Zhu

Contents:PET Imaging of Glutaminolysis in Tumors by

18F-(2S,4R)4-Fluoroglutamine

Reporter: Fei Liu

Supervisor: Prof. Zhi Yang

31 March 2014

Mentor: Nan Li and Hua Zhu

Contents:

Conten

ts:

Conten

ts:

1 Background 2 Research3 Summary 4Development

Conten

ts:

1 Background 2 Research3 Summary 4Development

1Background

Conten

ts:

1 Background 2 Research3 Summary 4Development

2Research

Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

2Research

Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

2Research

Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

2Research

Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

2Research

Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

2Research

Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

2Research

Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

Conten

ts:

1 Background 2 Research3 Summary 4Development

3Summary

The results support the feasibility of PET for the study of a fundamental change in tumor metabolism---high-rate glutaminolysis.

1 In vitro tumor cell uptake of 18F-(2S,4R)4-Fluoroglutamine is higer than uptake of 18F-FDG.

2In vivo PET studies showed significant tumor uptake adnd trapping inside tumor tissue in 2 different tuor models.

3

Conten

ts:

1 Background 2 Research3 Summary 4Development

4Development

Kung HF ， et al, Chemistry. Science, 2013 , 342(6157):429-30.

4Development

THANK THANK YOUYOU

TT

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