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PRINCIPLES OF PHARMACEUTICALS PROCESSING OF HERBAL AND MINERAL DRUGS
Anand ChaudharyAssociate Professor
Department of Rasa ShastraFaculty of Ayurveda
Institute of Medical Sciences Banaras Hindu University
Ayurvedic Astuteness
Questions /Contents
01- Are the principles of herbal drug processing and mineral drug processing same ?
02-Are there any parameters to know the physical change in source material ?
03-What are the reasons for selection of particular process of particular drug ?
04-What is the basis of selection of particular drugs for particular formulations ?
CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 3
Contd.
05 -What is the relevance of repetition cycles especially for production of Bhasma and Khalviya rasa kalpa ?
06-Principles of Stability are based on what logic ?
07-Is there any co relation between principles of formulations applied to Ayurvedic drugs and modern drugs ?
CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 4
Herbal Drug – Ayurvedic Medicine
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Authoritative Authentication
Classical considerations
Contemporary contemplations
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Sanitization & Storage
Separation
Segregation
Sustainable
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Processing
Mass transfer Solubility
Comminution Extraction
Herbal
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Container Consensus
Primary dosage forms
Secondary dosage forms
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Comminution
Size Reduction
Mechanical Pressure Solvency Procedures
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Extraction
Universal Solvent
Other Solutions
Suspensions
Nano suspensions
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Energy Agenda
Formulations
Intrinsic
Natural
Extrinsic
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Solvents
Aqueous
Oleaginous
Oil Ghee
Alcohol
Ethyl
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Completion Criteria
As per different dosage forms
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Procurement & Packing
As per Prepared Medicaments
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Delivery & Dispensing
As per indications of Physicians
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Mineral Drug – Ayurvedic Medicine
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Classical Connotation
Individualistic Identification
Conventional connotations
Current conjectures
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Processing
Shodhan – Specific
Bhavana – Bravura
Marana – Magnificent
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Contd .
Jarana
Satvapatan
Amritikaran
Lohitikaran
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Adaptations
Modification –
Physical (Heterogeneous to homogenous)
Chemical Conversion
Enhancement
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Impacts
Purification
Reduction in adverse effects
Induction of trace elements
Alteration in Constituencies
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Metallographic findings
Metallographic figure of Raw
Swarna Makshika (M= 400X).
Metallographic figure of ShodhitaSwarna Makshika (M= 400X).
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Initial Stride
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Marana
• Sukshmikaran (Fine powdering)
• Chakrika Nirmana (Pellet formation)- With other ingredients.
• Samputi Karana (Sealing in earthen vessels)
• Puta
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Intrinsic Worth
• Maximum Temperature range
• Duration of Maximum temperature
• Self Cooling
• Repetition of process
1. Hardness
2. Particle size
3. Chemical Constituents
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Vividness
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Explicitness
0
200
400
600
800
1000
1200
1 4 7 10 13 16 19
time in min. (1 = 15 units)
tem
pe
ra
tur
e
Temperature
(0C)
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Magnitude
Conversion
Potentiation
Elimination
Safety
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Makshika
SEM Feature of Raw S. M SEM Feature of Bhasma S. M
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Lauha Bhasma
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Neetu Singh et al , Chemical Characterization of Lauha Bhasma by X-Ray Diffraction and Vibrating Sample Magnetometry International Journal of Ayurvedic Medicine, 2010, 1(3), 143-149
25 July ,2011 32
Rasa Sindoor
Transmission electron microscopy (TEM) images (a, b, and c) along with selected area electron diffraction pattern (SAED) pattern (d) showing the presence of sub-micron size, agglomerated, and crystalline particles in the drug Rasa-Sindoor. S K Singh et al 2011 ,dept of Physics, BHU
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Rasa Sindoor
Scanning electron microscopy (SEM) image of the Rasa-Sindoor showing the plate like porous surface morphology. Inset to the figure shows the tiny voids presents in the material, S K Singh et al ,2011, Dept of Physics ,BHU
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Miscellaneous
Procurement Packing
Dispensing
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Manufacturing
Characterization
Safety & Efficacy
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Recent Researches
25 July ,2011 36
Scientific Approach Stakeholders
Deptt of AYUSH,GOI
Deptt of DST,GOI
Academic Institutes
Research Organizations
???????
Observations
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Characterizations
IIT ,Rooraki
Kumar A
IIT, Mumbai
Bellare Jayesh
IIT ,Kharagpur
Roy Subrato
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Safety
Schedule Y , D & C Rule 1945
Rule 170 , D & C Rule
1945 – 24 Dec , 2008
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Rays of Radiance
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Selective Selection
Artificial Addition Inherent Innate
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Supervises Solubility
Developmental Doctrine Progressive Preferences
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Probable Postulation
Bio accumulation Bio detoxification
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Reductionist Relativity
Contour Conversion Eternal Endowment
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Procedural Principles
Blending Thermodynamics
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Assertive Assumptions
Visionary Validation Rational Realization
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Extended Elegance
Explanation Elucidation
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Prominent Paramount
Herculean Herbal Metamorphic Metal
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Absolve Absorption
Organic Order Actual Accomplishment
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Pragmatic Paradigms
Momentous Mercury Poise Parada
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Authentic Authenticity
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Bhasma as Nano-medicine
Global Guidance Crucial Clause
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Exceptional Embodiment
Additional GMP Additional Certification
Stop Press
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Enlighten Endorsement
Causative Consultation Comprehensive communication
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Special Submission
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Wisdomnary Vision
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Exigency in Education
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Take Home Message
Indian Inheritance Authoritative Agenda
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Conclusion
Ayurveda is Super Science!
Rasa Shastra is Super Chemistry!
All is Well
Dosage forms of Rasa Shastra & Bhaishjya Kalpana - Super Pharmaceutics ?
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Acknowledgement
Prof A Wele ,Head , Dept of Rasa Shastra, College of Ayurveda, Bharati Vidyapeetha ,Pune
All Team Rasa Shastra , BV ,Pune
All Scholastic Scholars of Rasa Shastra at Pune from 25/07/2011 to 30/07/2011
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Thanks & All Good Wishes -----
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