PhRMA Report 2012: Medicines in Development for Cancer

Few things cause more fear and apprehension than a cancer diagnosis. But today—because of early detection and a steady stream of new and improved treatments—cancer increasingly can be managed and even beaten. But patients and their families are looking for more and bet-ter treatments, and America’s biopharmaceuti-cal research companies are responding.

Biopharmaceutical researchers are now work-ing on 981 medicines for cancer. Many are high-tech weapons to fight the disease, while some involve innovative research into using existing medicines in new ways.

Researchers’ deep commitment to patients and advancing science is at the core of the remark-able progress made in fighting cancer. In re-cent years we have seen significant declines in cancer deaths. The number of cancer survivors living in the United States has increased from 3 million in 1971 to nearly 12 million in 2008. The increase in survivors is attributed in large measure to earlier diagnosis and detection and better treatments and follow-up care.

America’s biopharmaceutical research com-panies are working on many new cutting-edge

approaches to fight cancer. They include:

• A medicine that interferes with the me-tabolism of cancer cells by depriving them of the energy provided by glucose.

• A medicine for acute myeloid leukemia (AML) that inhibits cancer cells with a mutation found in about a third of AML sufferers.

• A therapy that uses nanotechnology to target the delivery of medicines to cancer cells, potentially overcoming some limita-tions of existing treatments.

Despite recent progress, cancer remains the second leading cause of death by disease in the United States, exceeded only by heart disease. In 2012, some 577,190 Americans are expected to die of cancer—more than 1,500 people a day. The hundreds of new medicines to treat cancer now being developed are our best hope for lessening the burden of cancer to patients, their families and society.

More Than 900 Medicines and Vaccines in Clinical Testing Offer New Hope in the Fight Against Cancer

Medicines in Development

CanCerpresented by america’s biopharmaceutical research companies

2012 RepoRt

111

66

121117

94

Lym

phom

a

Col

orec

tal C

ance

rLu

ng C

ance

r

Pros

tate

Can

cer

Brea

st C

ance

r

67

Skin

Can

cer

Medicines in Development

for Selected Cancer Types

More Than

1.6 million New Cases of Cancer Are Expected This Year

Medicines in Development Cancer 20122

**For more information about a specific medicine in this report, please call the telephone number listed.

Lung Cancer

Liver Cancer

Leukemia

Kidney Cancer

Head/Neck Cancer

Colorectal Cancer

Cervical Cancer

Breast Cancer

Brain Cancer

Bladder Cancer 9

62

66

111

8

25

35

120

36

121

Multiple Myeloma

Lymphoma 117

57

Ovarian Cancer 63

Cancer-Related Conditions

Stomach Cancer

Solid Tumors

Skin Cancer

Sarcoma

Prostate Cancer

Pancreatic Cancer

94

58

21

67

280

23

38

Unspecified Cancer

Other Cancers 102

72

* Some medicines are listed in more than one category.

Medicines in Development for Cancer*

Medicines in Development for Cancer

Bladder CanCer

product Name Sponsor Indication Development Status*

Abraxane®

albumin-bound paclitaxelCelgeneSummit, NJ

second-line bladder cancer (see also breast, lung, ovarian, pancreatic, skin)

Phase II(908) 673-9000

AEZS-108 AEterna ZentarisBasking Ridge, NJ

(see also ovarian, prostate, other) Phase II(908) 626-5428

BC-819 (gene therapy)

BioCancell TherapeuticsJerusalem, Israel

(see also ovarian, pancreatic) Phase IIwww.biocancell.com

EN3488(mycobacterium cell wall-DNA complex)

Endo PharmaceuticalsChadds Ford, PA

non-muscle invasive bladder cancer(Fast Track)

Phase III(610) 558-9800

Medicines in Development Cancer 2012 3

Bladder CanCe

product Name Sponsor Indication Development Status

eoquin®

apaziquoneAllerganIrvine, CASpectrum PharmaceuticalsIrvine, CA

non-invasive bladder cancer(Fast Track)

Phase III(949) 788-6700

Folotyn®

pralatrexate(orphan Drug)

Allos TherapeuticsWestminster, CO

(see also breast, lung, lymphoma) Phase II(303) 426-6262

icrucumab(LY3012212/IMC-18F1)

Eli LillyIndianapolis, INImCloneBridgewater, NJ

(see also breast, colorectal) Phase II(800) 545-5979

tesetaxel GentaBerkeley Heights, NJ

second-line bladder cancer (see also breast, prostate, skin, stomach)

Phase II(908) 286-9800

VB4-845 Viventia BiotechnologiesMississauga, Canada

(see also head/neck) Phase II(905) 362-2973

Brain CanCer


8H9 I-131 mAb United TherapeuticsSilver Spring, MD

(see also sarcoma, other) Phase I(301) 608-9292

ABT-888(veliparib)(PARP inhibitor)

Abbott LaboratoriesAbbott Park, IL

(see also breast, colorectal, lung, lymphoma, ovarian, prostate, skin, other)

Phase I(847) 937-6100

AC480(pan-HER inhibitor)

Ambit BiosciencesSan Diego, CA

glioma(see also breast, lung)

Phase I(858) 334-2100

AEE788 Novartis PharmaceuticalsEast Hanover, NJ

glioblastoma Phase I/II(888) 669-6682

afatinib(BIBW2992)

Boehringer IngelheimPharmaceuticalsRidgefield, CT

glioblastoma(see also breast, head/neck, lung)

Phase I/II(800) 243-0127

APN301(ch14.18 mAb/interleukin-2 fusion protein)

Apeiron BiologicsVienna, Austria

neuroblastoma in children(see also skin)

Phase II completedwww.apeiron-biologics.com



Brain CanCer


AR-67 Arno TherapeuticsFlemington, NJ

glioblastoma(see also leukemia, solid tumors)

Phase II(862) 703-7170

ARC-100 Archer BiosciencesNew York, NY

glioblastoma (recurrent)(see also breast, prostate, skin)--------------------------------------------------neuroblastoma (combination therapy)--------------------------------------------------medulloblastoma (combination therapy)

Phase II(646) 747-9090-------------------------------------------Phase I/II(646) 747-9090-------------------------------------------Phase I(646) 747-9090

AT-101(oral pan Bcl-2 inhibitor)

Ascenta TherapeuticsMalvern, PA

glioblastoma(see also leukemia, lung, lymphoma, prostate, stomach)

Phase II(610) 408-0301

Avastin®

bevacizumabGenentechSouth San Francisco, CA

first-line glioblastoma multiforme (see also breast, colorectal, lung, ovarian, other)

Phase III(800) 626-3553

Azedra™metaiodobenzylguanidine I-131(orphan Drug)

Molecular Insights PharmaceuticalsCambridge, MA

neuroblastoma (pediatric) (Fast Track), paraganglioma, pheochromocytoma (Fast Track)

Phase II(617) 492-5554

bafetinib CytRx Los Angeles, CA

second-line brain cancer (see also leukemia, prostate)

Phase I(310) 826-5648

BKM120(PI3K inhibitor)

Novartis PharmaceuticalsEast Hanover, NJ

glioblastoma(see also breast, lung, other)

Phase I/II(888) 669-6682

ch14.18 mAb(orphan Drug)

United TherapeuticsSilver Spring, MD

neuroblastoma (children) Phase III(301) 608-9292

cilengitide(orphan Drug)

EMD SeronoRockland, MA

newly-diagnosed glioblastoma(combination therapy)(see also prostate)

Phase III(800) 283-8088

cintredekin besudotox(orphan Drug)

INSYS TherapeuticsPhoenix, AZ

glioma (adolescents and children)(Fast Track)

Phase I(602) 910-2617

Cotara®

monoclonal antibody TNT-1 (orphan Drug)

Peregrine PharmaceuticalsTustin, CA

recurrent glioblastoma(Fast Track)

Phase II(714) 508-6000

CPP-1X(eflornithine)

Cancer Prevention PharmaceuticalsTucson, AZ

neuroblastoma Phase I(520) 908-7774



Brain CanCer


crenolanib (CP-868-596)

AROG PharmaceuticalsDallas, TX

glioma (adults)(see also stomach)--------------------------------------------------glioma (pediatric)

Phase II(214) 594-0002-------------------------------------------Phase I(214) 594-0002

DCVax®-Brainbrain cancer vaccine(orphan Drug)

Northwest BiotherapeuticsBethesda, MD

glioblastoma Phase II(240) 497-9024

E7050 EisaiWoodcliff Lake, NJ

second-line glioblastoma (see also head/neck, liver, skin, solid tumors, stomach)

Phase I/II(888) 422-4743

E7080(lenvatinib)

EisaiWoodcliff Lake, NJ

glioma(see also skin, other)

Phase II(888) 422-4743

EPO-806(patupilone)


brain metastases from lung cancer(see also prostate)

Phase II(888) 669-6682

G-100 prophage cancer vaccine(vitespen)(orphan Drug)

AgenusLexington, MA

newly-diagnosed glioma Phase II(781) 674-4400

G-200 prophage cancer vaccine(vitespen)(orphan Drug)

AgenusLexington, MA

recurrent glioma Phase II(781) 674-4400

GliAtak™gene therapy(orphan Drug)

AdvantageneAuburndale, MA

glioma

--------------------------------------------------brain cancer (children)

Phase II(617) 916-5445-------------------------------------------Phase I(617) 916-5445

GMB-Vaxdendritic cell cancer vaccine

Activartis BiotechVienna, Austria

first-line glioblastoma Phase IIwww.activartis.com

GRN1005(LRP directed peptide-drugconjugate)

GeronMenlo Park, CA

brain metastases

--------------------------------------------------glioma

Phase II(650) 473-7700-------------------------------------------Phase I completed(650) 473-7700

GSK2118436(BRaf protein kinase inhibitor)

GlaxoSmithKlineRsch. Triangle Park, NC

brain metastases from melanoma(see also lung, skin)

Phase II(888) 825-5249

Hycamtin®

topotecanGlaxoSmithKlineRsch. Triangle Park, NC

metastatic brain cancer Phase III(888) 825-5249




Brain CanCer


ICT-107(dendritic cell vaccine)(orphan Drug)

ImmunoCellular TherapeuticsWoodland Hills, CA

glioblastoma Phase II(818) 992-2907

Levulan® pDtaminolevulinic acid

DUSA PharmaceuticalsWilmington, MA

Phase II(978) 657-7500

lonafarnib MerckWhitehouse Station, NJ

glioblastoma Phase I(800) 672-6372

Lucanix®

belagenpumatucel-LNovaRxSan Diego, CA

glioma(see also lung)

Phase I(858) 522-8600

macitentan Actelion Pharmaceuticals USSouth San Francisco, CA

glioblastoma (combination therapy) Phase I(650) 624-6900

MEDI-575(anti-PDGFR-alpha mAb)

AstraZenecaWilmington, DEMedImmuneGaithersburg, MD

glioblastoma(see also lung)

Phase II(800) 236-9933(301) 398-0000

mibefradil(T-type calcium channel inhibitor)(orphan Drug)

Tau TherapeuticsCharlottesville, VA


motexafin gadolinium PharmacyclicsSunnyvale, CA

glioblastoma (combination therapy) Phase II(408) 774-0330

nimotuzumab(orphan Drug)

YM Biosciences USALehigh Valley, PA

metastatic brain cancer, recurrent glioma (pediatric)(see also breast, prostate)

Phase II(610) 560-0600

olaratumab(LY3012207)

Eli LillyIndianapolis, INImClone SystemsBridgewater, NJ

glioblastoma(see also ovarian)

Phase II(800) 545-5979

opaxio™paclitaxel poliglumex

Cell TherapeuticsSeattle, WA

glioma, glioblastoma(see also lung, ovarian, stomach, other)

Phase II(800) 215-2355

perifosine AEterna ZentarisBasking Ridge, NJ

refractory metastatic glioma(see also colorectal, kidney, leukemia, lung, lymphoma, multiple myeloma, sarcoma, solid tumors, stomach)

Phase II(908) 626-5428



Brain CanCer


PLX3397(CSF-1R kinase inhibitor)

PlexxikonBerkeley, CA

recurrent glioblastoma(see also leukemia, lymphoma, solid tumors)

Phase II(510) 647-4000

Poly-ICLC(orphan Drug)

OncovirWashington, DC

anaplastic astrocytoma (adolescents and children), glioblastoma (adolescents and children)

Phase IIwww.oncovir.com

PX-866 OncothyreonSeattle, WA

second-line glioblastoma (see also head/neck, lung, prostate)

Phase II(206) 801-2100

Reolysin®

reovirusOncolytics BiotechCalgary, Canada

glioma(see also colorectal, head/neck, lung, ovarian, pancreatic, sarcoma,skin, solid tumors)

Phase I/II(403) 670-7377

rindopepimut(orphan Drug)

Celldex TherapeuticsNeedham, MA

first-line glioblastoma (Fast Track)--------------------------------------------------second-line glioblastoma (Fast Track)

Phase III(781) 433-0771-------------------------------------------Phase II(781) 433-0771

SB-313-xTZ Sangamo BiosciencesRichmond, CA


SBG Biotec PharmaconTromsø, Norway

neuroblastoma (pediatric) Phase I/II completedwww.biotec.no

SL-701(brain cancer vaccine)

Stemline TherapeuticsNew York, NY

glioma (adults)

--------------------------------------------------glioma (children)

Phase I/II(212) 831-1111-------------------------------------------Phase I/II(212) 831-1111

SpRYCeL®

dasatinibBristol-Myers SquibbPrinceton, NJ

glioblastoma(see also breast, pancreatic, prostate, other)

in clinical trials(800) 332-2056

tarceva®

erlotinib(orphan Drug)

GenentechSouth San Francisco, CAOSI PharmaceuticalsFarmingdale, NY

late-stage brain metastases, recurrent ependymoma (children), glioblastoma(see also breast, head/neck, leukemia, liver, lung, other)

Phase II(800) 626-3553(631) 962-0600

terameprocol Erimos PharmaceuticalsHouston, TX

glioma (intravenous)(see also cervical, head/neck, solid tumors, other)

Phase I/II(713) 541-2000

TGF-ß R1 inhibitor(LY2157299)

Eli LillyIndianapolis, IN

(see also liver) Phase II(800) 545-5979


Brain CanCer


TH-302 Threshold PharmaceuticalsSouth San Francisco, CA

astrocytoma(see also leukemia, multiple myeloma, pancreatic, sarcoma)

Phase II(650) 474-8200

Toca 511/Toca FC(cytosine deaminase gene therapy)

TocagenSan Diego, CA

glioblastoma Phase I/II(858) 412-8400

trans-sodium crocetinate (TSC)(orphan Drug)

Diffusion PharmaceuticalsCharlottesville, VA

gliobastoma Phase I/II(434) 220-0718

TVI-Brain-1(cellular immunotherapyvaccine)

TVAX BiomedicalLenexa, KS

glioma Phase II(913) 492-2221

VAL-083 Del Mar PharmaceuticalsVancouver, Canada

grade IV malignant glioma Phase I/II(604) 629-5989

VB-111 VBL TherapeuticsOr Yehuda, Israel

glioblastoma(see also other)

Phase I/IIwww.vblrx.com

Xeloda®

capecitabineGenentechSouth San Francisco, CA

newly-diagnosed glioma (adolescents and children)(see also colorectal, liver, stomach)

Phase I(800) 626-3553

Zelboraf®vemurafenib

GenentechSouth San Francisco, CAPlexxikonBerkeley, CA

brain metastases(see also colorectal, other)

Phase II(800) 626-3553

Breast CanCer


18F-fluorothymidine MerckWhitehouse Station, NJ

breast cancer (diagnosis) Phase II(800) 672-6372

Abraxane®


first-line metastatic breast cancer(see also bladder, lung, ovarian,pancreatic, skin)

Phase II(908) 673-9000

ABT-888 (veliparib)(PARP inhibitor)


(see also brain, colorectal, lung, lymphoma, ovarian, prostate, skin, other)

Phase II(847) 937-6100



(see also brain, lung) Phase I(858) 334-2100



Breast CanCer


acolbifene(4th-generation SERM)

EndoCeuticsQuebec, Canada

Phase II(418) 653-0033

AE37 peptide vaccine Antigen ExpressWorcester, MA

(see also ovarian) Phase II(508) 852-8783

afatinib(BIBW2992)


second-line metastatic breast cancer(see also brain, head/neck, lung)--------------------------------------------------first-line breast cancer


afimoxifene ASCEND TherapeuticsHerndon, VA

breast cancer (prevention) Phase II(703) 471-4744

Afinitor®

everolimusNovartis PharmaceuticalsEast Hanover, NJ

HER2-positive breast cancer(see also kidney, lymphoma)

Phase III(888) 669-6682

AFP464 KiraxBonita Springs, FL

Phase II(239) 444-5400

amrubicin CelgeneSummit, NJ

late-stage breast cancer (see also lung)

Phase I/II(908) 673-9000


(see also brain, prostate, skin) Phase II(646) 747-9090

ARRY-380(HER2 inhibitor)

Array BioPharmaBoulder, CO

Phase I(877) 633-2436

AUY922(Hsp90 inhibitor)


breast cancer (monotherapy)(see also colorectal, lung, multiple myeloma, stomach)--------------------------------------------------breast cancer (combination therapy)

Phase II(888) 669-6682

-------------------------------------------Phase I/II(888) 669-6682



Breast CanCer


Avastin®


adjuvant HER2-negative breast can-cer, adjuvant HER2-positive breast cancer, adjuvant triple negative breast cancer(see also brain, colorectal, lung, ovarian, other)

Phase III(800) 626-3553

AZD8931(erbB kinase inhibitor)

AstraZenecaWilmington, DE

advanced breast cancer (combination therapy)(see also solid tumors)

Phase II(800) 236-9933

BAY 86-5044 (lonaprisan)

Bayer HealthCare PharmaceuticalsWayne, NJ

metastatic breast cancer Phase II completed(888) 842-2937

BIIB 2024 Biogen IdecCambridge, MA

(see also stomach) Phase II completed(617) 679-2000



second-line breast cancer(see also brain, lung, other)

Phase I/II(888) 669-6682

breast cancer vaccine (dendritic cell vaccine)

Quantum ImmunologicsTampa, FL

Phase I/II(866) 213-4594

brostallicin Cell TherapeuticsSeattle, WA

triple-negative breast cancer Phase I(800) 215-2355

BTSCAN Molecular Targeting TechnologiesWest Chester, PA

breast cancer (diagnosis) Phase I(610) 738-7938

BZL-101 BionovoEmeryville, CA

Phase I(510) 601-2000

cabozantinib(XL184)

ExelixisSouth San Francisco, CA

(see also kidney, lung, ovarian, prostate, other)

Phase II(650) 837-7000

cancer vaccine MabVax TherapeuticsSan Diego, CA

(see also sarcoma) Phase I(858) 259-9405

CDX-011(glembatumumab vedotin)


breast cancer (Fast Track)(see also skin)

Phase II(781) 433-0771

CV-301(cancer vaccine)

BN ImmunoTherapeuticsMountain View, CA

metastatic breast cancer Phase II(650) 681-4660

D-1MT NewLink GeneticsAmes, IA

second-line metastatic breast cancer(see also solid tumors)

Phase I/II(515) 296-5555



Breast CanCer


dalotuzumab(MK-0646)

MerckWhitehouse Station, NJ

second-line breast cancer (combination therapy)(see also lung, pancreatic, other)--------------------------------------------------first-line breast cancer

Phase II(800) 672-6372

-------------------------------------------Phase I(800) 672-6372

DPX-0907 ImmunovaccineHalifax, Canada

(see also ovarian, prostate) Phase I(902) 492-1819

eniluracil Adherex TechnologiesRsch. Triangle Park, NC

metastatic breast cancer(combination therapy)

Phase II(919) 636-4530

entinostat Syndax PharmaceuticalsWaltham, MA

(see also colorectal, kidney, leukemia, lung, lymphoma)

Phase II(781) 419-1400

etirinotecan pegol (NKTR-102)

Nektar TherapeuticsSan Francisco, CA

metastatic breast cancer(see also colorectal, ovarian, solid tumors)

Phase III(855) 482-6587

EZN-2208(PEG-SN38, firtecan pegol)

Enzon PharmaceuticalsPiscataway, NJ

metastatic breast cancer(see also colorectal, solid tumors)

Phase II(973) 980-4500

Faslodex®

fulvestrantAstraZenecaWilmington, DE

first-line advanced breast cancer Phase III(800) 236-9933

folate binding protein (E39) vaccine

Galena BiopharmaLake Oswego, OR

(see also ovarian, other) Phase I(855) 855-4253

Folotyn®pralatrexate


(see also bladder, lung, lymphoma) Phase II(303) 426-6262

ganetespib (Hsp90i)

Synta PharmaceuticalsLexington, MA

(see also colorectal, leukemia, liver, lung, multiple myeloma, pancreatic, prostate, skin, stomach)

Phase II(781) 274-8200

ganitumab(AMG 479)

AmgenThousand Oaks, CA

combination therapy(see also colorectal, lung, pancreatic, sarcoma)

Phase II(800) 772-6436

GDC-0980(PI3 kinase/mTOR dual inhibitor)

GenentechSouth San Francisco, CA

hormone receptor-positive breast cancer(see also lymphoma, solid tumors)

Phase II(800) 626-3553

GSK2302024A(WT1 antigen-specific cancerimmunotherapeutic)


neoadjuvant breast cancer Phase I/II(888) 825-5249

GVAX® Breastcancer vaccine

BioSante PharmaceuticalsLincolnshire, IL

Phase I(847) 478-0500



Breast CanCer


HER2 antigen-specific cancerimmunotherapeutic


Phase II(888) 825-5249



metastatic breast cancer(see also bladder, colorectal)

Phase II(800) 545-5979

imetelstat GeronMenlo Park, CA

metastatic breast cancer(combination therapy)(see also leukemia, lung, multiple myeloma)

Phase II(650) 473-7700

IMT-1012 immunotherapeuticvaccine

ImmunotopeDoylestown, PA

(see also ovarian) Phase I(215) 253-4180

indibulin(ZIO-301)

ZIOPHARM OncologyNew York, NY

late-stage breast cancer Phase I/II(646) 214-0700

iniparib(BSI-201)

Sanofi USBridgewater, NJ

neoadjuvant breast cancer(see also lung, ovarian)

Phase II(800) 981-2491

KW-2450 Kyowa Hakko Kirin PharmaPrinceton, NJ

first-line breast cancer, second-line breast cancer

Phase I/II(609) 919-1100

LFA102(anti-prolactin receptor anti-body)

Novartis PharmaceuticalsEast Hanover, NJXOMABerkeley, CA

(see also prostate) Phase I(888) 669-6682

LGK974(WNT signaling pathway inhibitor)


(see also skin) Phase I(888) 669-6682

linifanib Abbott LaboratoriesAbbott Park, IL

breast cancer (combination therapy)(see also colorectal, kidney, liver, lung)

Phase II(847) 937-6100

liposome encapsulated paclitaxel (LEP-ETU)

Insys TherapeuticsPhoenix, AZ

Phase II(602) 910-2617

litronesib(LY2523355)


metastatic breast cancer(see also lung)

Phase II(800) 545-5979

LOR-2040 Lorus TherapeuticsToronto, Canada

metastatic breast cancer(see also colorectal, kidney, leukemia, prostate)

Phase II(416) 798-1200

Lymphoseek®

Tc-99m tilmanoceptNavidea PharmaceuticalsDublin, OH

breast cancer (diagnosis)(see also head/neck, skin)

application submitted(614) 793-7500



Breast CanCer


maraciclatide GE HealthcareWaukesha, WI

breast cancer (diagnosis) in clinical trialswww.gehealthcare.com

MK-0752(notch signaling pathway inhibitor)


early-stage breast cancer, late-stage breast cancer(see also other)

Phase I(800) 672-6372

MK-2206(c-akt inhibitor)


HER2-positive breast cancer(see also other)

Phase I(800) 672-6372

MM-111 Merrimack PharmaceuticalsCambridge, MA

breast cancer (combination therapy) Phase I/II(617) 441-1000

MM-302(anti-HER2 antibody doxorubicin conjugate)

Merrimack PharmaceuticalsCambridge, MA

Phase I(617) 441-1000

motesanib AmgenThousand Oaks, CA

(see also colorectal, lung, other) Phase I/II(800) 772-6436

MVA-BN® HeR2(HER-2/neu-based MVA vaccine)


Phase I(650) 681-4660

Myocet™doxorubicin liposomal

Sopherion TherapeuticsPrinceton, NJ

first-line breast cancer (combination therapy) (Fast Track)

Phase III(609) 986-2020

NeuVax™cancer vaccine E75


early-stage breast cancer(prevention of relapse)(see also prostate)

Phase III(855) 855-4253

Nexavar®

sorafenibBayer HealthCare PharmaceuticalsWayne, NJ

(see also colorectal, head/neck, kidney, leukemia, liver, lung, multiple myeloma, ovarian, other)

Phase III(888) 842-2937

nimotuzumab YM Biosciences USALehigh Valley, PA

(see also brain, prostate) Phase I(610) 560-0600

NK-012 Nippon KayakuTokyo, Japan

(see also lung) Phase IIwww.nipponkayaku.co.jp

OBP-301 Oncolys BiopharmaTokyo, Japan

(see also head/neck, liver, lung) Phase Iwww.oncolys.com

OGX-427 OncoGenex PharmaceuticalsBothell, WA

(see also lung, ovarian) Phase I(425) 686-1500



Breast CanCer


onartuzumab GenentechSouth San Francisco, CA

metastatic breast cancer (combination therapy)(see also colorectal, lung)

Phase II(800) 626-3553

OPT-822/OPT-821 Optimer BiotechnologySan Diego, CA

Phase II/III(858) 909-0736

PB-272 (neratinib) Puma BiotechnologyLos Angeles, CA

second-line breast cancer, neoadjuvant breast cancer

Phase II(424) 248-6500

pertuzumab GenentechSouth San Francisco, CA

first-line metastatic breast cancer

--------------------------------------------------second-line late-stage breast cancer

application submitted(800) 626-3553-------------------------------------------Phase II(800) 626-3553

pertuzumab companion diagnostic(HER2 FISH pharmDx™)

DakoGlostrup, DenmarkGenentechSouth San Francisco, CA

breast cancer (diagnostic) Phase IIIwww.dako.com(800) 626-3553

pertuzumab companiondiagnostic(HercepTest™)


breast cancer (diagnosis) Phase IIIwww.dako.com(800) 626-3553

pixantrone Cell TherapeuticsSeattle, WA

breast cancer (Fast Track)(see also lymphoma)

Phase II(800) 215-2355

PTC299 PTC TherapeuticsSouth Plainfield, NJ

(see also solid tumors, other) Phase I/II(908) 222-7000

Quinamed®

amonafideCephalonFrazer, PA

(see also ovarian, prostate) Phase II(610) 344-0200

ramucirumab(IMC-1121B)


metastatic breast cancer(see also colorectal, stomach)

Phase III(800) 545-5979

Reximmune-C®

personalized cancer vaccineEpeius BiotechnologiesSan Marino, CA

Phase I/II(626) 441-6695

Rexin-G® Epeius BiotechnologiesSan Marino, CA

metastatic breast cancer(see also pancreatic, sarcoma)

Phase I/II(626) 441-6695



Breast CanCer


ridaforolimus ARIAD PharmaceuticalsCambridge, MAMerckWhitehouse Station, NJ

metastatic breast cancer(see also kidney, lung, prostate, sarcoma, other)

Phase II(800) 672-6372

rucaparib Clovis OncologyBoulder, CO

(see also ovarian) Phase II(303) 625-5000

sagopilone Bayer HealthCare PharmaceuticalsWayne, NJ

(see also ovarian, prostate) Phase II completed(888) 842-2937

samarium SM-153 lexidronaminjection

EUSA PharmaLanghorne, PA

(see also multiple myeloma, prostate, sarcoma, other)

Phase II(800) 833-3533

SAR245408 (XL147)(oral PI3K inhibitor)

Sanofi USBridgewater, NJExelixis South San Francisco, CA

(see also other) Phase II(800) 981-2491(650) 837-7000

SAR245409 (XL765)(PI3K/mTOR inhibitor)


(see also lymphoma) Phase II(800) 981-2491(650) 837-7000

SAR256212 (MM-121)(anti-ErbB3 mAb)

Merrimack PharmaceuticalsCambridge, MASanofi USBridgewater, NJ

(see also lung, ovarian) Phase II(800) 981-2491

SF1 (sonodynamic therapy) SonneMedBoston, MA

advanced breast cancer Phase I/IIwww.sonnemed.com

SpRYCeL®


(see also brain, pancreatic, prostate, other)


SR 16234 SRI InternationalMenlo Park, CA

Phase II(650) 859-2000

tarceva®

erlotinibGenentechSouth San Francisco, CAOSI PharmaceuticalsFarmingdale, NY

(see also brain, head/neck, leukemia, liver, lung, other)

Phase II(800) 626-3553(631) 962-0600


first-line breast cancer (see also bladder, prostate, skin, stomach)

Phase II(908) 286-9800



Breast CanCer


thermoDox®

doxorubicin liposomalCelsionLawrenceville, NJ

recurrent breast cancer(see also colorectal, liver)

Phase I/II(609) 896-9100

tigatuzumab(anti-DR5 antibody)

Daiichi SankyoParsippany, NJ

(see also colorectal, liver, lymphoma, ovarian, pancreatic)

Phase II(973) 944-2600

tivozanib(ASP4130/AV-951)

Astellas Pharma USDeerfield, ILAVEO PharmaceuticalsCambridge, MA

breast cancer (combination therapy)(see also colorectal, kidney)

Phase I/II(800) 695-4321(617) 299-5000

TKI258(dovitinib)


metastatic breast cancer(see also kidney, multiple myeloma, prostate, skin, other)

Phase II(888) 669-6682

trabectedin Johnson & Johnson PharmaceuticalResearch & DevelopmentRaritan, NJ

metastatic breast cancer (see also ovarian, prostate, sarcoma)

Phase III(800) 817-5286

trastuzumab-DM1(RG3502)


Phase III(800) 626-3553

trastuzumab-DM1 companion diagnostic(HercepTest™)



trastuzumab-DM1 companion diagnostic(HER2 FISH pharmDx™)



TRC 105(ENG protein inhibitor)

TRACON PharmaceuticalsSan Diego, CA

(see also ovarian, prostate, other) Phase I/II(858) 550-0780

trebananib (AMG386)


(see also colorectal, kidney, liver, ovarian, stomach, other)

Phase II(800) 772-6436

tykerb®

lapatinibGlaxoSmithKlineRsch. Triangle Park, NC

inflammatory breast cancer (see also colorectal, head/neck, stomach)--------------------------------------------------adjuvant breast cancer, first-line metastatic breast cancer--------------------------------------------------neoadjuvant breast cancer


-------------------------------------------Phase III(888) 825-5249-------------------------------------------Phase II(888) 825-5249

upamostat (WX-671)

WilexMunich, Germany

Phase IIwww.wilex.de



Breast CanCer


varlitinib ASLAN PharmaceuticalsSingapore

Phase IIwww.aslanpharma.com

VeriStrat®companion diagnostic testEGFR-TKI

BiodesixBoulder, CO

advanced breast cancer (diagnosis-outcome test in HER2-overexpressing tumors)

Phase III(303) 417-0500

YM155(sepantronium)

Astellas Pharma USDeerfield, IL

(see also lymphoma) Phase II(800) 695-4321

Zolinza®

vorinostatMerckWhitehouse Station, NJ

(see also leukemia, lung, lymphoma, multiple myeloma, other)

Phase II(800) 672-6273

Zytiga®

abirateroneJanssen BiotechHorsham, PA

second-line metastatic breast cancer(see also prostate)

Phase II(800) 526-7736

CerviCal CanCer


ADXS-HPV AdvaxisPrinceton, NJ

cervical cancer, cervical intraepithelial neoplasia

Phase II(609) 452-9813

PM-00104 PharmaMarMadrid, Spain

(see also sarcoma, other) Phase IIwww.pharmamar.com

PV701(replication-competent oncolytic virus)

Wellstat BiologicsGaithersburg, MD

(see also colorectal) Phase II(240) 683-2500


cervical intraepithelial neoplasia (intravaginal)(see also brain, head/neck, solid tumors, other)

Phase II(713) 541-2000

V503(HPV virus-like particle (VLP) vaccine)


prevention of cervical cancer, prevention of vulvovaginal cancer

Phase III(800) 672-6372

V505(HPV vaccine)


prevention of cervical cancer Phase II completed(800) 672-6372



CerviCal CanCer


verpasep caltespen(cancer vaccine)

Akela PharmaAustin, TX

cervical intraepithelial neoplasia Phase I completed(512) 834-0449

VGX-3100(DNA cancer vaccine)

Inovio PharmaceuticalsBlue Bell, PA

cervical intraepithelial neoplasia Phase II(877) 446-6846

ColoreCtal CanCer




(see also brain, breast, lung, lymphoma, ovarian, prostate, skin, other)

Phase II(847) 937-6100

Aptocine™talaporfin

Light Sciences OncologyBellevue, WA

metastatic colorectal cancer Phase III(425) 957-8900



second-line colorectal cancer (combination therapy)(see also breast, lung, multiplemyeloma, stomach)

Phase I(888) 669-6682

Avastin®


metastatic colorectal cancer (treatment beyond progression) (see also brain, breast, lung, ovarian, other)

Phase III(800) 626-3553

AVX701(CEA cancer immunotherapy)

AlphaVaxRsch. Triangle Park, NC

colorectal cancer prevention in patients with advanced or metastatic CEA-expressing malignancies

Phase I/II(919) 595-0400

belinostat Spectrum PharmaceuticalsHenderson, NV

colorectal cancer (combination therapy)(see also leukemia, liver, lung, lymphoma, ovarian, other)

Phase I/II(702) 835-6300

brivanib(VEGFR/FGFR kinase inhibitor)

Bristol-Myers SquibbPrinceton, NJ

metastatic colorectal cancer(see also liver, sarcoma)

Phase II(800) 332-2056

CPX-1(irinotecan/floxuridine)

Celator PharmaceuticalsPrinceton, NJ

Phase II completed(609) 243-0123

CT-011 CureTechYavne, Israel

first-line metastatic colorectal cancer (combination therapy)(see also leukemia, lymphoma)

Phase IIwww.curetechbio.com


Phase II(888) 422-4743



ColoreCtal CanCer


efatutazone Daiichi SankyoParsippany, NJ

metastatic colorectal cancer(see also lung, other)

Phase II(973) 944-2600

EGEN-001 EGENHuntsville, AL

(see also ovarian, other) Phase I/II(256) 512-0077

EGFR antagonist companion diagnostic

QIAGENValencia, CA

colorectal cancer (diagnosis) application submittedwww.qiagen.com

encapsulated cell therapy(macrobeads)

Rogosin InstituteNew York, NY

refractory metastatic colorectal cancer(see also pancreatic, prostate)

Phase II(212) 746-1566


metastatic colorectal cancer(combination therapy)(see also breast, kidney, leukemia, lung, lymphoma)

Phase II(781) 419-1400

eRBItUX®

cetuximabBristol-Myers SquibbPrinceton, NJEli LillyIndianapolis, IN

first-line colorectal cancer(see also stomach)

in clinical trials(800) 332-2056(800) 545-5979

etirinotecan pegol(NKTR-102)


second-line colorectal cancer(see also breast, ovarian, solid tumors)

Phase II/III(855) 482-6587



metastatic colorectal cancer(see also breast, solid tumors)

Phase II(973) 980-4500

FANG™ Vaccineautologous tumor cell vaccine

GradalisCarrollton, TX

(see also ovarian, skin) Phase II(214) 442-8100

ganetespib (Hsp90i)


refractory, metastatic colorectal cancer(see also breast, leukemia, liver, lung, multiple myeloma, pancreatic, prostate, skin, stomach)

Phase II(781) 274-8200

ganitumab(AMG 479)


second-line metastatic colorectal cancer (combination therapy)(see also breast, lung, pancreatic, sarcoma)

Phase II(800) 772-6436

GI-4000(cancer vaccine)

GlobeImmuneLouisville, CO

(see also lung, pancreatic) Phase II(303) 625-2700



ColoreCtal CanCer


GM-CT-01 Galectin TherapeuticsNewton, MA

colorectal cancer (combination therapy)

Phase II(617) 559-0033

GS-6624(monoclonal antibody)

Gilead SciencesFoster City, CA

(see also pancreatic) Phase II(800) 445-3235

GVAX® Colorectalcancer vaccine


Phase I(847) 478-0500



(see also bladder, breast) Phase II(800) 545-5979

IMO-2055(TLR9 agonist)

Idera PharmaceuticalsCambridge, MA

(see also head/neck, lung) Phase I(617) 679-5000

Imprime pGG® BiotheraEagan, MN

(see also leukemia, lung, skin) Phase III(651) 675-0300

JX-594 (pexastimogene devacirepvec)

Jennerex BiotherapeuticsSan Francisco, CA

(see also liver) Phase I/II(415) 281-8886

KRN-330 Kyowa Hakko Kirin PharmaPrinceton, NJ

colorectal cancer (combination therapy)--------------------------------------------------colorectal cancer (monotherapy)

Phase I/II(609) 919-1100-------------------------------------------Phase I(609) 919-1100

labetuzumab I-131(IMMU-111)

ImmunomedicsMorris Plains, NJ

Phase II(973) 605-8200

labetuzumab-SN-38(IMMU-130)


Phase I(973) 605-8200

LGX818(RAF inhibitor)


metastatic colorectal cancer(see also skin)

Phase I(888) 669-6682


second-line colorectal cancer(see also breast, kidney, liver, lung)

Phase II(847) 937-6100


metastatic colorectal cancer(see also breast, kidney, leukemia, prostate)

Phase II(416) 798-1200


(see also breast, lung, other) Phase I(800) 772-6436



ColoreCtal CanCer


Nexavar®


metastatic colorectal cancer (see also breast, head/neck, kidney, leukemia, liver, lung, multiple myeloma, ovarian, other)

Phase II(888) 842-2937

NPC-1C(ensituximab)

Neogenix OncologyRockville, MD

metastatic colorectal cancer(see also pancreatic)

Phase I(301) 917-6893


(see also breast, lung) Phase II(800) 626-3553

oncoVAX®

active specific immunotherapyVaccinogenFrederick, MD

(Fast Track) Phase I/II(301) 668-8400


refractory metastatic colorectal cancer (combination therapy)(Fast Track)(see also brain, kidney, leukemia, lung, lymphoma, multiple myeloma, sarcoma, solid tumors, stomach)

Phase III(908) 626-5428

PHY906 PhytoCeuticaNew Haven, CT

(see also liver, pancreatic, cancer-related)

Phase I/II(203) 777-3462

picoplatin Ponaird PharmaceuticalsSeattle, WA

(see also lung, ovarian, prostate) Phase II(206) 281-7001

polyclonal antibody stimulator Cancer AdvancesDurham, NC

(see also pancreatic, stomach) Phase II(919) 361-2162

PV701(replication-competent oncolytic virus)

Wellstat BiologicsGaithersburg, MD

(see also cervical) Phase II(240) 683-2500



(see also breast, stomach) Phase III(800) 545-5979

regorafenib Bayer HealthCare PharmaceuticalsWayne, NJ

metastatic colorectal cancer (Fast Track)(see also kidney, lung, solid tumors, stomach)

Phase III(888) 842-2837

Reolysin®


(see also brain, head/neck, lung, ovarian, pancreatic, sarcoma,skin, solid tumors)

Phase I(403) 670-7377



ColoreCtal CanCer


RG7160(EGFR inhibitor)

RocheNutley, NJ

second-line metastatic colorectal cancer (combination therapy)

Phase II(973) 235-5000

RG7414(EGFL7 inhibitor)


(see also lung) Phase II(800) 626-3553

RIGScan™tumor-specific, radio-labeled monoclonal antibody targeting agent

Navidea BiopharmaceuticalsDublin, OH

metastatic colorectal cancer (diagnosis)


robatumumab MerckWhitehouse Station, NJ

(see also sarcoma, solid tumors) Phase II completed(800) 672-6372

Sym004 SymphogenLyngby, Denmark

metastatic colorectal cancer Phase IIwww.symphogen.com

TAS-102 Taiho Pharma U.S.A.Princeton, NJ

Phase I(609) 750-5300

telatinib ACT BiotechSan Francisco, CA

(see also stomach) Phase I(415) 230-3900

TF2(pretargeted radioimmuno-therapy)


colorectal cancer Phase I(973) 605-8200

thermoDox®

doxorubicin liposomalCelsionLawrenceville, NJ

adjuvant inoperable/unresectable, metastatic colorectal cancer(see also breast, liver)

Phase II(609) 896-9100



(see also breast, liver, lymphoma, ovarian, pancreatic)

Phase I(973) 944-2600

tivantinib (ARQ 197)

ArQuleWoburn, MADaiichi SankyoParsippany, NJ

(see also kidney, liver, lung, pancreatic, sarcoma, other)

Phase I/II(781) 994-0300(973) 944-2600



colorectal cancer (combination therapy)(see also breast, kidney)

Phase II(800) 695-4321(617) 299-5000

trebananib (AMG386)


(see also breast, kidney, liver, ovarian, stomach, other)

Phase II(800) 772-6436

tykerb®


metastatic colorectal cancer(see also breast, head/neck, stomach)

Phase II(888) 825-5249



ColoreCtal CanCer


Vectibix®

panitumumabAmgenThousand Oaks, CA

first-line and second-line colorectal cancer (see also head/neck)


Xeloda®


first-line and second-line metastatic colorectal cancer (combination therapy)(see also brain, liver, stomach)


Zaltrap™aflibercept

Regeneron PharmaceuticalsTarrytown, NYSanofi USBridgewater, NJ

second-line metastatic colorectal cancer(see also prostate)

application submitted(914) 345-7400(800) 981-2491



(see also brain, other) Phase I(800) 626-3553

Head/neCk CanCer


ACE-041(dalantercept)

Acceleron PharmaCambridge, MA

(see also multiple myeloma) Phase II(617) 649-9200

afatinib(BIBW2992)


second-line head/neck cancer(see also breast, brain, lung)

Phase II(800) 243-0127

AP5346 Access PharmaceuticalsDallas, TX

Phase II(214) 905-5100


(see also brain, liver, skin, solid tumors, stomach)

Phase I/II(888) 422-4743

foretinib(GSK1363089)


(see also kidney, liver, lung) Phase II completed(888) 825-5249

GL-0810(orphan Drug)

GliknikBaltimore, MD

Phase Iwww.gliknik.com

GL-0817(orphan Drug)

GliknikBaltimore, MD

(see also multiple myeloma) Phase Iwww.gliknik.com

HF-10 Takara BioShiga, Japan

Phase Iwww.takara-bio.com



Head/neCk CanCer




second-line head and neck cancer(combination therapy)(see also colorectal, lung)

Phase II(617) 679-5000

IRX-2 IRX TherapeuticsNew York, NY

(Fast Track) Phase II(212) 582-1199

Lymphoseek®


head and neck cancer (diagnosis)(see also breast, skin)

Phase III(614) 793-7500

Multikine®

leukocyte interleukin(orphan Drug)

CEL-SCIVienna, VA

first-line head and neck cancer Phase III(703) 506-9460

Nexavar®


(see also breast, colorectal, kidney, leukemia, liver, lung, multiple myeloma, ovarian, other)

Phase II(888) 842-2937


(see also breast, liver, lung) Phase Iwww.oncolys.com


head and neck cancer (combination therapy)(see also brain, lung, prostate)

Phase II(206) 801-2100

Reolysin®


metastatic head and neck cancer (combination therapy)(see also brain, colorectal, lung, ovarian, pancreatic, sarcoma, skin, solid tumors)

Phase III(403) 670-7377

RG7597(EGFR antagonist)


Phase II(800) 626-3553

seliciclib(CYC202)

Cyclacel PharmaceuticalsBerkeley Heights, NJ

nasopharyngeal cancer (see also solid tumors)

Phase II(908) 517-7330

tarceva®


first-line head/neck cancer (combination therapy)(see also brain, breast, leukemia,liver, lung, other)

Phase II(800) 626-3553(631) 962-0600

TAS-106 Taiho Pharma U.S.A.Princeton, NJ

Phase II(609) 750-5300



Head/neCk CanCer



head and neck cancer (intratumoral)(see also brain, cervical, solid tumors, other)

Phase I(713) 541-2000

tNFerade™golnerminogene pradenovec

GenVecGaithersburg, MD

(see also prostate, skin, stomach) Phase I/II completed(877) 943-6832

tykerb®


head and neck squamous cell carcinoma (resectable disease)(see also breast, colorectal, stomach)

Phase III(888) 825-5249

VB4-845(orphan Drug)

Viventia BiotechnologiesMississauga, Canada

(Fast Track)(see also bladder)

Phase II(905) 362-2973

Vectibix®

panitumumabAmgenThousand Oaks, CA

first-line head and neck cancer(see also colorectal)--------------------------------------------------second-line head and neck cancer


kidney CanCer


Afinitor®


hepatocellular carcinoma(see also breast, lymphoma)

Phase II(888) 669-6682

AGS-003(personalized dendritic cell vaccine)

Argos TherapeuticsDurham, NC

renal cancer (combination therapy)(Fast Track)--------------------------------------------------metastatic renal cancer (monotherapy)

Phase II(919) 287-6300-------------------------------------------Phase II(919) 287-6300

AMG 172 AmgenThousand Oaks, CA

Phase I(800) 772-6436

anti-PD1 (BMS-936558)


renal cell carcinoma(see also lung, skin)

Phase II(800) 332-2056

BNC105 BionomicsThebarton, Australia

Phase IIwww.bionomics.com.au

cabozantinib(XL184)


renal cell carcinoma(see also breast, lung, ovarian, prostate, other)

Phase I(650) 837-7000



kidney CanCer


CVX 060 (PF-04856884)(Ang2 antagonist)

PfizerNew York, NY

renal cell carcinoma(see also solid tumors)

Phase II(860) 732-5156

CYT107(interleukin-7)

CytherisRockville, MD

(see also skin) Phase I(301) 231-0451


(see also breast, colorectal, leukemia, lung, lymphoma)

Phase I/II(781) 419-1400



(see also head/neck, liver, lung) Phase II(888) 825-5249

IMA901(cancer vaccine)

immatics biotechnologiesTüebingen, Germany

renal cancer Phase IIIwww.immatics.com

Inlyta®

axitinib(orphan Drug)

PfizerNew York, NY

advanced renal cell carcinoma in treatment-naive patients(see also liver, other)

Phase III(860) 732-5156

Istodax®

romidepsinCelgeneSummit, NJ

renal cancer(see also pancreatic, prostate, other)

Phase II(908) 673-9000

LBH589 (panobinostat)


renal cancer(see also leukemia, multiple myeloma, prostate, solid tumors)

Phase II(888) 669-6682


renal cancer (see also breast, colorectal, liver, lung)

Phase II(847) 937-6100

LOR-2040(orphan Drug)

Lorus TherapeuticsToronto, Canada

metastatic renal cancer(see also breast, colorectal, leukemia, prostate)

Phase II(416) 798-1200

naptumomab estafenatox Active BiotechLund, Sweden

(see also lung, pancreatic) Phase I completedwww.activebiotech.com

Nexavar®


renal cell carcinoma (adjuvant therapy)(see also breast, colorectal, head/neck, leukemia, liver, lung, multiple myeloma, ovarian, other)

Phase III(888) 842-2937

oncophage®

vitespen(orphan Drug)

AgenusLexington, MA

renal cell carcinoma (Fast Track) Phase II(781) 674-4400

OSI-027(TORC1/TORC2 inhibitor)

OSI PharmaceuticalsFarmingdale, NY

renal cancer(see also lymphoma)

Phase II(631) 962-0600



kidney CanCer



metastatic renal cancer(see also brain, colorectal, leukemia, lung, lymphoma, multiple myeloma, sarcoma, solid tumors, stomach)

Phase II(908) 626-5428

Redectane®

girentuximab I-124 companion diagnostic


renal cancer (diagnosis) Phase III completedwww.wilex.de


renal cancer(see also colorectal, lung, solid tumors, stomach)

Phase II(888) 842-2837

Rencarex®

girentuximab(orphan Drug)


clear cell renal cell carcinoma(Fast Track)

Phase IIIwww.wilex.de


(see also breast, lung, prostate, sarcoma, other)

Phase I(800) 672-6372

SGN-75(vorsetuzumab mafodotin)

Seattle GeneticsBothell, WA

renal cancer(see also lymphoma)

Phase I(425) 527-4000

Sutent®sunitinib(orphan Drug)

PfizerNew York, NY

renal cell carcinoma (adjuvant therapy)

Phase III(860) 732-5156



(see also colorectal, liver, lung, pancreatic, sarcoma, other)

Phase II(781) 994-0300(973) 944-2600



first-line renal cancer (see also breast, colorectal)

--------------------------------------------------renal cancer(combination therapy)

Phase III(800) 695-4321(617) 299-5000-------------------------------------------Phase I(800) 695-4321(617) 299-5000

TKI258(dovitinib)


(see also breast, multiple myeloma, prostate, skin, other)

Phase III(888) 669-6682

torisel®temsirolimus(orphan Drug)

PfizerNew York, NY

renal cell carcinoma Phase III(860) 732-5156

trebananib (AMG386)


renal cancer(see also breast, colorectal, liver, ovarian, stomach, other)

Phase II(800) 772-6436



kidney CanCer


TVI-Kidney-1(cellular immunotherapyvaccine)

TVAX BiomedicalLenexa, KS

renal cell carcinoma Phase II completed(913) 492-2221

veglin (VEGF antisense)

VasGene TherapeuticsLos Angeles, CA

(see also lung, skin) Phase I(323) 221-7818

Votrient™pazopanib


(see also ovarian, other) Phase III(888) 825-5249

leukemia


ABIO-0501 (TALL104)

Abiogen PharmaPisa, Italy

chronic myeloid leukemia (CML) Phase IIwww.abiogen.it

AC220(quizartinib)

Ambit BiosciencesSan Diego, CAAstellas Pharma USDeerfield, IL

second-line and third-line acute myeloid leukemia (AML) (monotherapy)(see also solid tumors)--------------------------------------------------acute lymphocytic leukemia (ALL) (combination therapy), first-line AML

Phase II(858) 334-2100(800) 695-4321

-------------------------------------------Phase I(858) 334-2100(800) 695-4321

AC430(JAK2 inhibitor)


Phase I(858) 334-2100

Adcetris™brentuximab vedotin

Millennium PharmaceuticalsCambridge, MASeattle GeneticsBothell, WA

(see also lymphoma) Phase II(800) 390-5663(425) 527-4000

AEG35156(XIAP inhibitor)

Aegera TherapeuticsMontreal, Canada

AML(see also lymphoma)--------------------------------------------------chronic lymphocytic leukemia (CLL)

Phase II(514) 288-5532-------------------------------------------Phase I/II(514) 288-5532

AFX-9154 Afecta PharmaceuticalsIrvine, CA




leukemia


AGS-005 Argos TherapeuticsDurham, NC

CLL Phase I/II(919) 287-6300

ALD-151 AldagenDurham, NC

Phase I(919) 484-2571

ALXN6000(samalizumab)

Alexion PharmaceuticalsCheshire, CT

CLL(see also multiple myeloma)

Phase I/II completed(203) 272-2596

aminopterin Syntrix BiosystemsAuburn, WA

ALL Phase II completed(253) 833-8009

anti-CD22/CD19 mAb-toxinconjugate

Abiogen PharmaPisa, Italy

ALL Phase Iwww.abiogen.com


CLL(see also lymphoma, multiple myeloma)

Phase I/II(862) 703-7170


myelodysplastic syndromes(see also brain, solid tumors)

Phase II(862) 703-7170

Arranon®

nelarabine(orphan Drug)


first-line ALL(see also lymphoma)--------------------------------------------------second-line ALL

Phase III(888) 669-6682-------------------------------------------Phase I/II(888) 669-6682

ARRY-520(KSP inhibitor)


AML(see also multiple myeloma, solid tumors)

Phase II(877) 633-2436

Arzerra®

ofatumumab(orphan Drug)


first-line CLL (combination therapy)(see also lymphoma)

Phase III(888) 825-5249



CLL(see also brain, lung, lymphoma, prostate, stomach)

Phase II(610) 408-0301

AT-406/Debio-1143 Ascenta TherapeuticsMalvern, PADebiopharmLausanne, Switzerland

AML(see also lymphoma)

Phase I(610) 408-0301www.debiopharm.com



leukemia


AT7519(CDK inhibitor)

Astex PharmaceuticalsDublin, CA

CLL(see also lymphoma, multiple myeloma, solid tumors)

Phase II(925) 560-0100

AT9283(aurora/Jak2 inhibitor)(orphan Drug)


AML(see also lymphoma, multiple myeloma, solid tumors)

Phase I/II(925) 560-0100

AVL-292(Btk inhibitor)

CelgeneSummit, NJ

second-line CLL (combination therapy)(see also lymphoma, unspecified)

Phase I(908) 673-9000

AZD1208(Pim kinase inhibitor)


AML Phase I(800) 236-9933

bafetinib(orphan Drug)

CytRx Los Angeles, CA

second-line CLL (see also brain, prostate)--------------------------------------------------ALL, CML

Phase II(310) 826-5648-------------------------------------------Phase I(310) 826-5648

Bcl-2 inhibitor(ABT-199/GDC-0199)

Abbott LaboratoriesAbbott Park, ILGenentechSouth San Francisco, CA

CLL(see also lymphoma)

Phase I(847) 937-6100(800) 626-3553


AML(see also colorectal, liver, lung, lymphoma, ovarian, other)

Phase I/II(702) 835-6300

BI-811283(aurora kinase B inhibitor)


AML(see also solid tumors)

Phase I/II(800) 243-0127

BI-836826 Boehringer IngelheimPharmaceuticalsRidgefield, CT

CLL Phase I(800) 243-0127

bosutinib PfizerNew York, NY

previously treated CML application submitted(860) 732-5156

cenersen(orphan Drug)

EleosOmaha, NE

AML Phase II completed(402) 393-3034

Ceplene®

histamine dihydrochloride injection(orphan Drug)

EpiCeptTarrytown, NY

AML application submitted(914) 606-3500



leukemia


CLL immunotherapeutic vaccine MaxCyteGaithersburg, MD

CLL Phase I/II(301) 944-1700

Clolar®

clofarabine injection (orphan Drug)

GenzymeCambridge, MA

AML (adults) Phase III(617) 252-7500

CNDO-109(tumor activated NK cells)

Coronado BiosciencesBurlington, MA

AML Phase I(781) 238-6621

CPX-351(cytarabine/daunorubicin)(orphan Drug)

Celator PharmaceuticalsPrinceton, NJ

AML Phase II(609) 243-0123


second-line AML (combination therapy)(see also colorectal, lymphoma)


CWP232291 JW PharmaceuticalSeoul, South Korea

AML Phase I

Dacogen®

decitabineEisaiWoodcliff Lake, NJ

AML

--------------------------------------------------pediatric AML


danusertib Nerviano Medical SciencesNerviano, Italy

CML Phase IIwww.nervianoms.com

DCC-2036 Deciphera PharmaceuticalsLawrence, KS

ALL, CML

--------------------------------------------------AML

Phase I/II(785) 830-2100-------------------------------------------Phase I(785) 830-2100

DCDS-4501A GenentechSouth San Francisco, CA


Phase I(800) 626-3553

DCDT-2980S GenentechSouth San Francisco, CA

recurrent CLL(see also lymphoma)

Phase I(800) 626-3553

elacyt™elacytarabine(orphan Drug)

Clavis PharmaOslo, Norway

late-stage AML(Fast Track)--------------------------------------------------early-stage AML

Phase IIIwww.clavispharma.com-------------------------------------------Phase IIwww.clavispharma.com



leukemia


elesclomol Synta PharmaceuticalsLexington, MA

AML(see also lung, ovarian)

Phase I(781) 274-8200


(see also breast, colorectal, kidney, lung, lymphoma)

Phase II(781) 419-1400

epratuzumab(orphan Drug)

ImmunomedicsMorris Plains, NJUCBAtlanta, GA

ALL in children (combination therapy)(see also lymphoma)

Phase II(973) 605-8200

forodesine(orphan Drug)

BioCryst PharmaceuticalsDurham, NC


Phase II(919) 859-1302

ganetespib (Hsp90i)


ALL, AML, CML(see also breast, colorectal, liver, lung, multiple myeloma, pancreatic, prostate, skin, stomach)--------------------------------------------------myelodysplastic syndromes

Phase I/II(781) 274-8200

-------------------------------------------Phase I(781) 274-8200

GNKG-168 SBI BiotechTokyo, Japan

CLL Phase Iwww.sbibiotech.jp

GRNVAC1(dendritic cell vaccine)

Argos TherapeuticsDurham, NCGeronMenlo Park, CA

AML(see also prostate)

Phase II(650) 473-7700

GS-1101(PI3K delta inhibitor)


second-line CLL (see also lymphoma)

Phase III(800) 445-3235

GSK2110183(protein kinase B inhibitor)



GSK2130579A(WT1 antigen-specific cancer immunotherapeutic)


AML Phase II(888) 825-5249

GVAX® Leukemiacancer vaccine(orphan Drug)


AML, CML Phase II(847) 478-0500

HuM195-Ac-225(lintuzumab Ac-225)

Actinium PharmaceuticalsNewark, NJ

AML Phase I(973) 344-6500



leukemia


HuM195-Bi-213(lintuzumab Bi-213)

Actinium PharmaceuticalsNewark, NJ

AML Phase I/II(973) 344-6500

HuM195/rGel(lintuzumab-gelonin conjugate)

Targa TherapeuticsSan Diego, CA

AML, CML, myelodysplasticsyndromes

Phase I(858) 483-6600

ibrutinib(PCI-32765)

Janssen BiotechHorsham, PAPharmacyclicsSunnyvale, CA

CLL(see also lymphoma, multiple myeloma)

Phase I/II(800) 526-7736(408) 774-0330

imatinib sublingual Kedem PharmaceuticalsMesa, AZ

CML in clinical trials(604) 324-4244


CLL(see also breast, lung, multiple myeloma)

Phase I/II(650) 473-7700


CLL(see also colorectal, lung, skin)

Phase I/II(651) 675-0300

INNO-305(WT-1 vaccine)

CytRxLos Angeles, CA

AML, myelodysplastic syndromes(see also solid tumors)

Phase I(310) 826-5648

inotuzumab ozogamicin PfizerNew York, NY

ALL(see also lymphoma)

Phase I(860) 732-5156

ISF35(recombinant immunotherapeutic vaccine)

MemgenSan Diego, CA

CLL (monotherapy)(see also lymphoma)--------------------------------------------------refractory metastatic CLL (combination therapy)

Phase II(858) 524-5400-------------------------------------------Phase I(858) 524-5400

JNJ-26481585(quisinostat)

Johnson & Johnson PharmaceuticalResearch & DevelopmentRaritan, NJ

myelodysplastic syndromes, metastatic leukemia(see also lymphoma)

Phase I(800) 817-5286

JVRS-100(lipid-DNA complex vaccine)

Colby PharmaceuticalSan Jose, CA

Phase I(650) 333-3152

KX2-391 Kinex PharmaceuticalsBuffalo, NY

AML in the elderly(see also prostate)

Phase I(716) 898-8626



leukemia




ALL, AML, myelodysplastic syndromes(see also kidney, multiple myeloma, prostate, solid tumors)

Phase II(888) 669-6682

LDE225(erismodegib)


CML (combination therapy)(see also pancreatic, solid tumors, skin)

Phase I(888) 669-6682

lestaurtinib(orphan Drug)

CephalonFrazer, PA

AML Phase II(610) 344-0200

leukemia DNA vaccine Inovio PharmaceuticalsBlue Bell, PAUniversity of SouthamptonSouthampton, United Kingdom

AML, CML Phase II(877) 446-6846

LG740(activated T-cells)

LentigenGaithersburg, MDUniversity of PennsylvaniaPhiladelphia, PA

ALL, B-cell prolymphocytic leukemia, CLL(see also lymphoma)

Phase I(301) 527-4200

LOR-2040(orphan Drug)


AML (combination therapy)(see also breast, colorectal, kidney, prostate)--------------------------------------------------CML, myelodysplastic syndromes

Phase II(416) 798-1200

-------------------------------------------Phase I (416) 798-1701

lurbinectedin PharmaMarMadrid, Spain

(see also solid tumors) Phase Iwww.pharmamar.com

Marqibo®

vincristine liposomal(orphan Drug)

Talon TherapeuticsSan Mateo, CA

relapsed or refractory Philadelphia chromosome-negative ALL (Fast Track)(see also lymphoma, skin, other)--------------------------------------------------ALL in the elderly (Fast Track)


-------------------------------------------Phase III(650) 588-6404

milatuzumab ImmunomedicsMorris Plains, NJ

CLL (monotherapy)(see also lymphoma, multiple myeloma)

Phase I/II(973) 605-8200

MK-7956(dinaciclib)(orphan Drug)



Phase II(800) 672-6372



leukemia


MK-8242 MerckWhitehouse Station, NJ


Phase I(800) 672-6372

mocetinostat(MGCD0103, HDAC inhibitor)

MethylGeneMontreal, Canada

CLL(see also lymphoma, solid tumors)


Mozobil®plerixafor


AML Phase I(617) 252-7500

navitoclax(ABT-263)


first-line CLL (combination therapy)(see also lung, lymphoma)--------------------------------------------------CLL, lymphoid leukemia

Phase II(847) 937-6100-------------------------------------------Phase I(847) 937-6100

Nexavar®


AML, myelodysplastic syndromes(see also breast, colorectal, head/neck, kidney, liver, lung, multiple myeloma, ovarian, other)

Phase I/II(888) 842-2937

obatoclax(orphan Drug)

CephalonFrazer, PA

CLL(see also lung, lymphoma, multiple myeloma)


obinutuzumab(GA101/RG7159)

Biogen IdecWeston, MAGenentechSouth San Francisco, CA

first-line CLL (combination therapy)(see also lymphoma)

Phase III(781) 464-2000(800) 626-3553

omapro™omacetaxine(orphan Drug)

CephalonFrazer, PA

second-line CML(see also solid tumors)--------------------------------------------------AML, myelodysplastic syndromes


ON 013105 Onconova TherapeuticsNewtown, PA

ALL(see also lymphoma)

Phase I(267) 759-3680

oral azacitidine(orphan Drug)

CelgeneSummit, NJ

myelodysplastic syndromes(Fast Track) (see also lung, lymphoma, solid tumors)--------------------------------------------------AML, CML

Phase II(908) 673-9000

-------------------------------------------Phase I(908) 673-9000



leukemia


oral clofaribine GenzymeCambridge, MA

myelodysplastic syndromes Phase I(617) 252-7500

OVI-123(orphan Drug)

OncoVista Innovative TherapiesSan Antonio, TX

TdT-positive leukemia Phase I(210) 677-6000

OXi4503 OXiGENESouth San Francisco, CA

AML, myelodysplastic syndromes Phase I(650) 635-7000


refractory metastatic CLL(see also brain, colorectal, kidney, lung, lymphoma, multiple myeloma, sarcoma, solid tumors, stomach)

Phase II(908) 626-5428

PKC412(midostaurin)


AML Phase III(888) 669-6682



recurrent or refractory AML(see also brain, lymphoma, solid tumors)

Phase I/II(510) 647-4000

ponatinib(orphan Drug)

ARIAD PharmaceuticalsCambridge, MA

Philadelphia-positive ALL, CML

--------------------------------------------------AML

Phase II(617) 494-0400-------------------------------------------Phase I(617) 494-0400

PR104 ProactaLa Jolla, CA

AML Phase I/II(858) 642-0386

Revlimid®

lenalidomide(orphan Drug)

CelgeneSummit, NJ

CLL, myelodysplastic syndromes(see also lymphoma)

Phase III(908) 673-9000

rigosertib(orphan Drug)

Onconova TherapeuticsNewtown, PA

myelodysplastic syndromes (intravenous)(see also lymphoma, ovarian, pancreatic)--------------------------------------------------CLL

--------------------------------------------------AML

--------------------------------------------------myelodysplastic syndromes (oral)

Phase III(267) 759-3680

-------------------------------------------Phase II(267) 759-3680-------------------------------------------Phase I/II(267) 759-3680-------------------------------------------Phase I(267) 759-3680



leukemia


sapacitabine (CYC682)(orphan Drug)


first-line AML (see also lung, solid tumors)--------------------------------------------------CLL (combination therapy),myelodysplastic syndromes


SB989 (pracinostat)

S*BIOOakland, CA

myelodysplastic syndromes(see also solid tumors, other)

Phase I(650) 730-2860

SB1518 (pacritinib)

S*BIOOakland, CA

myelodysplastic syndromes

--------------------------------------------------myeloid leukemia


SF1126(orphan Drug)

Semafore PharmaceuticalsIndianapolis, IN

CLL(see also multiple myeloma, solid tumors)

Phase I(317) 876-3075

SGI110(DNMT inhibitor)


AML, myelodysplastic syndromes Phase I/II(925) 560-0100

SL-401(recombinant fusion protein)(orphan Drug)

Stemline TherapeuticsNew York, NY

AML, myelodysplastic syndromes Phase I/II(646) 502-2310

tamibarotene(orphan Drug)


acute promyelocytic leukemia (APL) (Fast Track)(see also lung)--------------------------------------------------APL (combination therapy)

Phase II(310) 826-5648

-------------------------------------------Phase I(310) 826-5648

tarceva®

erlotinibGenentechSouth San Francisco, CAOSI OncologyFarmingdale, NY

myelodysplastic syndromes(see also brain, breast, head/neck, liver, lung, other)

Phase II(800) 626-3553(631) 962-0600

tasigna®

nilotinib(orphan Drug)


CML (adolescents and children), ALL (adolescents and children)(see also skin, stomach)

Phase II(888) 669-6682

temodar®

temozolomideMerckWhitehouse Station, NJ

AML(see also lung)

Phase II(800) 672-6372


(see also brain, multiple myeloma, pancreatic, sarcoma)

Phase I(650) 474-8200

thiarabine Access PharmaceuticalsDallas, TX

(see also lymphoma) Phase I/II(215) 904-5100



leukemia


TL-32711(birinapant)

TetraLogic PharmaceuticalsMalvern, PA


Phase I/II(610) 889-9900

tosedostat(orphan Drug)

Chroma TherapeuticsOxon, United Kingdom

AML Phase IIwww.chromatherapeutics.com

trametinib GlaxoSmithKlineRsch. Triangle Park, NC

relapsed or refractory leukemia(see also brain, lung, lymphoma, multiple myeloma, pancreatic, skin)

Phase III(888) 825-5249

treanda®

bendamustineCephalonFrazer, PA

ALL in children, AML in children(see also lymphoma, multiple myeloma)

Phase I/II(610) 344-0200

treosulfan MedacWedel, Germany

ALL, AML, myelodysplastic syndromes

Phase IIwww.medac.de

TRU-016(humanized anti-CD37 therapeutic)

Emergent BioSolutionsRockville, MD


Phase II(301) 795-1800

Velcade®

bortezomibMillennium PharmaceuticalsCambridge, MA

second-line T-cell prolymphocytic leukemia (see also lymphoma, other, cancer-related)

Phase II(800) 390-5663

veltuzumab(orphan Drug)



Phase I/II(973) 605-8200

Vidaza®

azacitidine(orphan Drug)

CelgeneSummit, NJ

AML in the elderly(see also lymphoma)

Phase III(908) 673-9000

vosaroxin(orphan Drug)

Sunesis PharmaceuticalsSouth San Francisco, CA

second-line AML(Fast Track)(see also ovarian)--------------------------------------------------AML in the elderly

Phase III(650) 266-3739

-------------------------------------------Phase II(650) 266-3739

XmAb® 5574(MOR208, anti-CD19 mAb)

MorphoSysPlanegg, GermanyXencorMonrovia, CA

recurrent CLL Phase Iwww.morphosys.com(626) 305-5900

Zolinza®


AML, myelodysplastic syndromes(see also breast, lung, lymphoma, multiple myeloma, other)

Phase II(800) 672-6273



liver CanCer


ALN-VSP Alnylam PharmaceuticalsCambridge, MA

Phase I(617) 551-8200

bavituximab Peregrine PharmaceuticalsTustin, CA

(see also lung, pancreatic) Phase I/II(715) 508-6000

BAY 86-9766(MEK inhibitor)

Ardea BiosciencesSan Diego, CABayer HealthCare PharmaceuticalsWayne, NJ

first-line liver cancer (combination therapy)(see also pancreatic)

Phase II(888) 842-2937


inoperable/unresectable liver cancer(see also colorectal, leukemia, lung, lymphoma, ovarian, other)

Phase I/II(702) 835-6300


(see also lung) Phase I completed(617) 679-2000



first-line liver cancer, liver cancer (TACE)(see also colorectal, sarcoma)

Phase III(800) 332-2056

cixutumumab(LY3012217/IMC-A12)



darinaparsin(ZIO-101)


(see also lymphoma, multiple myeloma, solid tumors)

Phase II(646) 214-0700

DC Bead®

doxorubicin-eluting beadsBayer HealthCare PharmaceuticalsWayne, NJBiocompatiblesSurrey, United Kingdom

Phase II(888) 842-2937


(see also brain, head/neck, skin, solid tumors, stomach)

Phase I/II(888) 422-4743



(see also head/neck, kidney, lung) Phase I(888) 825-5249

ganetespib (Hsp90i)


(see also breast, colorectal, leukemia, lung, multiple myeloma, pancreatic, prostate, skin, stomach)

Phase II(781) 274-8200

Inlyta®

axitinibPfizerNew York, NY

(see also kidney, other) Phase II(860) 732-5156

irinotecan eluting beads Biocompatibles InternationalSurrey, United Kingdom

liver metastases from colorectal cancer

Phase IIwww.biocompatibles.com



liver CanCer


JX-594 (pexastimogene devacirepvec)(orphan Drug)

Jennerex BiotherapeuticsSan Francisco, CA


lansoprazole (orphan Drug)

Apricus BiosciencesSan Diego, CA

first-line liver cancer Phase II(858) 220-8041


first-line liver cancer (monotherapy)(see also breast, colorectal, kidney, lung)

Phase III(847) 937-6100

mapatumumab Human Genome SciencesRockville, MD

liver cancer (combination therapy)(see also lung, multiple myeloma)

Phase II(301) 309-8504

MB07133(HepDirect HepB inhibitor)

Ligand PharmaceuticalsLa Jolla, CA

inoperable/unresectable liver cancer Phase I/II completed(858) 550-7500

melphalan drug delivery system Delcath SystemsNew York, NY

inoperable/unresectable liver cancer application submitted(212) 489-2100

muparfostat (PI-88) Progen PharmaceuticalsQueensland, Australia

liver cancer (Fast Track)(see also skin)

Phase IIIwww.progen.com.au

Nexavar®

sorafenib(orphan Drug)


heptocellular carcinoma (adjuvant therapy)(see also breast, colorectal, head/neck, kidney, leukemia, lung, multiple myeloma, ovarian, other)

Phase III(888) 842-2937

NV-1020 CatherexPhiladelphia, PA

Phase I/II completed


(see also breast, head/neck, lung) Phase Iwww.oncolys.com

PEG arginine deiminase (ADI-PEG 20)

Polaris PharmaceuticalsSan Diego, CA

hepatocellular carcinoma(see also prostate, skin, other)

Phase III(858) 452-6688


(see also colorectal, pancreatic, cancer-related)


PV-10(rose bengal sodium)(orphan Drug)

Provectus PharmaceuticalsKnoxville, TN

liver cancer, liver metastases(see also skin)

Phase I(866) 594-5999

RG7686 RocheNutley, NJ

metastatic liver cancer(combination therapy)

Phase II(973) 235-5000



liver CanCer


tarceva®


first-line inoperable/unresectable liver cancer (combination therapy)(see also brain, breast, head/neck, leukemia, lung, other)--------------------------------------------------second-line liver cancer (combination therapy)

Phase III(800) 626-3553(631) 962-0600

-------------------------------------------Phase II(800) 626-3553(631) 962-0600

TGF-ß R1 inhibitor(LY2157299)


(see also brain) Phase II(800) 545-5979

thermoDox®

doxorubicin liposomal(orphan Drug)

CelsionLawrenceville, NJ

first-line inoperable/unresectable liver cancer (Fast Track)(see also breast, colorectal)

Phase III(609) 896-9100



(see also breast, colorectal, lymphoma, ovarian, pancreatic)

Phase II(973) 944-2600

tivantinib (ARQ 197) ArQuleWoburn, MADaiichi SankyoParsippany, NJ

second-line liver cancer (see also colorectal, kidney, lung, pancreatic, sarcoma, other)--------------------------------------------------liver cancer (combination therapy)

Phase II(781) 994-0300(973) 944-2600------------------------------------------Phase I(781) 994-0300(973) 944-2600

trebananib (AMG386)


(see also breast, colorectal, kidney, ovarian, stomach, other)

Phase II(800) 772-6436

Xeloda®


biliary cancer (combination therapy)(see also brain, colorectal, stomach)

Phase II(800) 626-3553

Zadaxin®

thymalfasin alfa 1(orphan Drug)

SciClone PharmaceuticalsFoster City, CA

(see also skin) Phase II/III(650) 358-3456



lung CanCer


Abraxane®


first-line non-small-cell lung cancer (NSCLC)(see also bladder, breast, ovarian, pancreatic, skin)




NSCLC(see also brain, breast, colorectal, lymphoma, ovarian, prostate, skin, other)

Phase II(847) 937-6100



NCSLC(see also brain, breast)

Phase I(858) 334-2100

Actimid®

pomalidomideCelgeneSummit, NJ

small-cell lung cancer (SCLC)(see also lymphoma, multiple myeloma, pancreatic)

Phase I/II(908) 673-9000

afatinib(BIBW2992)


first-line NSCLC(see also brain, breast, head/neck)--------------------------------------------------second-line NSCLC (Fast Track)

Phase III(800) 243-0127-------------------------------------------Phase II/III(800) 243-0127

Alimta®

pemetrexedEli LillyIndianapolis, IN

first-line and maintenance NSCLC Phase III(800) 545-5979

AMG888/U3-1287(anti-HER3 antibody)

AmgenThousand Oaks, CADaiichi SankyoParsippany, NJ

NSCLC Phase II(800) 772-6436(973) 944-2600

amrubicin(orphan Drug)

CelgeneSummit, NJ

SCLC (Fast Track)(see also breast)--------------------------------------------------first-line SCLC


amuvatinib(MP470)


SCLC (combination therapy)(see also lymphoma)

Phase II(925) 560-0100



(see also kidney, skin) Phase II(800) 332-2056

AP26113 ARIAD PharmaceuticalsCambridge, MA

NSCLC Phase I(617) 494-0400

apricoxib(TG01)

Tragara PharmaceuticalsSan Diego, CA

second-line NSCLC (combination therapy)(see also pancreatic)

Phase II(858) 350-6900



lung CanCer


astuprotimut-R(MAGE-A3 antigen-specific cancer immunotherapeutic)


adjuvant NSCLC (see also skin)

Phase III(888) 825-5249



NSCLC (combination therapy), SCLC (combination therapy) (see also brain, leukemia, lymphoma, prostate, stomach)

Phase II(610) 408-0301



third-line NSCLC(see also breast, colorectal, multiple myeloma, stomach)--------------------------------------------------second-line late-stage NSCLC(combination therapy)

Phase II(888) 669-6682

-------------------------------------------Phase I/II(888) 669-6682

Avastin®


adjuvant NSCLC (see also brain, breast, colorectal, ovarian, other)

Phase III(800) 626-3553


first-line NSCLC, second-line NSCLC(see also liver, pancreatic)

Phase II(715) 508-6000


mesothelioma(see also colorectal, leukemia, liver, lymphoma, ovarian, other)--------------------------------------------------NSCLC

--------------------------------------------------SCLC


-------------------------------------------Phase I/II(702) 835-6300-------------------------------------------Phase I(702) 835-6300


NSCLC(see also liver)

Phase I completed(617) 679-2000



late-stage NSCLC (see also brain, breast, other)

Phase II(888) 669-6682

cabozantinib(XL184)


NSCLC(see also breast, kidney, ovarian, prostate, other)

Phase I/II(650) 837-7000

CBP-501(peptide mimetic)

CanBasShizouka, Japan

mesothelioma (combination therapy), first-line NSCLC (combination therapy)(see also solid tumors)

Phase IIwww.canbas.co.jp



lung CanCer


CC-223(mTOR inhibitor)

CelgeneSummit, NJ

NSCLC(see also lymphoma, multiple myeloma)

Phase I(908) 673-9000

CEP-9722(PARP inhibitor)

CephalonFrazer, PA

NSCLC (combination therapy)(see also lymphoma)

Phase II(610) 344-0200

Chk1 inhibitor(LY2603618)


NSCLC(see also pancreatic)

Phase II(800) 545-5979

cixutumumab(LY3012217/IMC-A12)


NSCLC(see also liver)

Phase II(800) 545-5979

CLR1404-I-124 Novelos TherapeuticsMadison, WI

NSCLC (diagnosis) Phase I/II(608) 441-8120

CLR1404-I-131 Novelos TherapeuticsMadison, WI

NSCLC (diagnosis) Phase I/II(608) 441-8120

CO-1686(EGFR inhibitor)

Clovis OncologyBoulder, CO

second-line NSCLC Phase I/II(303) 625-5000

custirsen(OGX-001/TV-1011)

OncoGenex PharmaceuticalsBothell, WATeva PharmaceuticalsTikva, Israel

first-line NSCLC(see also prostate)

Phase II(425) 686-1500

dacomitinib(PF-00299804)

PfizerNew York, NY

NSCLC(see also solid tumors)

Phase III(860) 732-5156



recurrent NSCLC (combination therapy)(see also breast, pancreatic, other)

Phase II(800) 672-6372

EC20(technetium Tc-99m etarfolatide)

EndocyteWest Lafayette, IN

NSCLC (diagnosis)(see also ovarian)

Phase IIwww.endocyte.com

EC145(vintafolide)

EndocyteWest Lafayette, INMerckWhitehouse Station, NJ

NSCLC(see also ovarian)

Phase IIwww.endocyte.com(800) 672-6372


NSCLC(see also colorectal, other)

Phase II(973) 944-2600


NSCLC(see also leukemia, ovarian)

Phase I/II(781) 274-8200



lung CanCer


emepepimut-S EMD SeronoRockland, MAOncothyreonSeattle, WA

NSCLC (Fast Track)(see also prostate)

Phase III(800) 283-8088


NSCLC (combination therapy)(see also breast, colorectal, kidney, leukemia, lymphoma)

Phase II(781) 419-1400

ficlatuzumab(AV-299)

AVEO PharmaceuticalsCambridge, MA

NSCLC (combination therapy)(see also solid tumors)

Phase II(617) 299-5000

Folotyn®

pralatrexateAllos TherapeuticsWestminster, CO

NSCLC(see also bladder, breast, lymphoma)

Phase II(303) 426-6262



NSCLC (see also head/neck, kidney, liver)

Phase I/II(888) 825-5249

ganetespib (Hsp90i)


second-line NSCLC (combination therapy)(see also breast, colorectal, leukemia, liver, multiple myeloma, pancreatic, prostate, skin, stomach)--------------------------------------------------SCLC

Phase II/III(781) 274-8200

-------------------------------------------Phase II(781) 274-8200

ganitumab(AMG 479)


first-line SCLC (combination therapy)(see also breast, colorectal, pancreatic, sarcoma)

Phase I/II(800) 772-6436



NSCLC(see also colorectal, pancreatic)

Phase I(303) 625-2700

Gleevec®

imatinibNovartis PharmaceuticalsEast Hanover, NJ

NSCLC (combination therapy)(see also prostate, skin, other)

Phase II(888) 669-6682



BRAF mutation-positive disease NSCLC(see also brain, skin)

Phase II(888) 825-5249

Halaven®

eribulinEisaiWoodcliff Lake, NJ

NSCLC(see also prostate, sarcoma)

Phase III(888) 422-4743

HS-110(cancer vaccine)

Heat BiologicsChapel Hill, NC

late-stage NSCLC (combination therapy)

Phase I(919) 240-7133



lung CanCer


HyperAcute® Lunglung cancer immunotherapy

NewLink GeneticsAmes, IA

metastatic NSCLC Phase II(515) 296-5555

IDM-2101(multi-epitope cancer vaccine)

Biotech SynergySan Diego, CA

NSCLC Phase II(858) 459-6689


late-stage NSCLC(see also breast, leukemia, multiple myeloma)

Phase II(650) 473-7700



(see also colorectal, head/neck) Phase I(617) 679-5000


NSCLC(see also colorectal, leukemia, skin)

Phase II(651) 675-0300

iniparib(BSI-201)


squamous NSCLC(see also breast, ovarian)--------------------------------------------------non-squamous NSCLC


Iressa®

gefitinibAstraZenecaWilmington, DE

first-line EGFR mutation-positiveNSCLC

Phase III(800) 236-9933

ISIS-EIF4ERx Isis PharmaceuticalsCarlsbad, CA

late-stage NSCLC (combination therapy)(see also prostate)

Phase II(800) 679-4747

JNJ-26854165(Hdm2 inhibitor)

Johnson & Johnson Pharmaceutical Research & DevelopmentRaritan, NJ

NSCLC(see also prostate, solid tumors)

Phase I(800) 817-5286

Karenitecin®

BNP1350BioNumerik PharmaceuticalsSan Antonio, TX

NSCLC(see also ovarian, solid tumors)

Phase II(210) 614-1701

KD019(SSKI inhibitor)

Kadmon PharmaceuticalsWarrendale, PA

late-stage NSCLC Phase III(724) 778-6100

KD032(ras/mTOR inhibitor)


NSCLC(see also pancreatic)



NSCLC(see also breast, colorectal, kidney, liver)

Phase II(847) 937-6100

litronesib(LY2523355)


NSCLC(see also breast)

Phase II(800) 545-5979



lung CanCer


lorvotuzumab mertansine(IMGN901)(orphan Drug)

ImmunoGenWaltham, MA

SCLC(see also multiple myeloma)

Phase II(781) 895-0600

Lucanix®

belagenpumatucel-LNovaRxSan Diego, CA

NSCLC (Fast Track)(see also brain)

Phase III(858) 522-8600


NSCLC (combination therapy)(see also liver, multiple myeloma)

Phase II(301) 309-8504

MEDI-575(anti-PDGFR-alpha mAb)


NSCLC(see also brain)

Phase II(800) 236-9933(301) 398-0000

MGCD265(multi-kinase inhibitor)


NSCLC (combination therapy) Phase I/II(514) 337-3333

MORAb-003(farletuzumab)



Phase II(888) 422-4743

MORAb-009(amatuximab)


mesothelioma Phase II(888) 422-4743


NSCLC(see also breast, colorectal, other)

Phase III(800) 772-6436


NSCLC (Fast Track)(see also kidney, pancreatic)

Phase I completedwww.activebiotech.com

navitoclax(ABT-263)


NSCLC, SCLC(see also leukemia, lymphoma)

Phase II(847) 937-6100

necitumumab(IMC-11F8)

Bristol-Myers SquibbPrinceton, NJEli LillyIndianapolis, INImClone SystemsBridgewater, NJ

NSCLC Phase III(800) 332-2056(800) 545-5979

Nexavar®


NSCLC(see also breast, colorectal, head/neck, kidney, leukemia, liver, multiple myeloma, ovarian, other)

Phase III(888) 842-2937



lung CanCer


NGR-hTNF(orphan Drug)

MolMedMilan, Italy

second-line mesothelioma Phase IIIwww.molmed.com

NK-012 Nippon KayakuTokyo, Japan

SCLC(see also breast)

Phase IIwww.nipponkayaku.co.jp

NTX-010 NeotropixMalvern, PA

SCLC(see also other)

Phase IIwww.neotropix.com

obatoclax CephalonFrazer, PA

first-line SCLC(see also leukemia, lymphoma, multiple myeloma)

Phase II(610) 344-0200


mesothelioma(see also breast, head/neck, liver)

Phase Iwww.oncolys.com


NSCLC(see also breast, ovarian)

Phase I(425) 686-1500

ombrabulin (AVE8062)


first-line NSCLC (see also ovarian, sarcoma)

Phase II(800) 981-2491


metastatic NSCLC(see also breast, colorectal)

Phase III(800) 626-3553

oncoprex™(TUSC2/FUS1 gene therapy)

GenprexAustin, TX

NSCLC Phase I(512) 597-5900



NSCLC(see also brain, ovarian, stomach, other)

Phase III(800) 215-2355

oral azacitidine CelgeneSummit, NJ

NSCLC(see also leukemia, lymphoma, solid tumors)

Phase I(908) 673-9000

OSI-906(IGF-1R/1R tyrosinase kinase inhibitor)


NSCLC(see also ovarian, other)

Phase II(631) 962-0600

P2045 Bryan OncorSomerville, MA

NSCLC, SCLC Phase I completed

palifosfamide(ZIO-201)


SCLC(see also sarcoma, solid tumors)

Phase I(646) 214-0700



lung CanCer


pegdinetanib (VEGFR-2 adnectin)(BMS-844203)




NSCLC(see also brain, colorectal, kidney, leukemia, lymphoma, multiple myeloma, sarcoma, solid tumors, stomach)

Phase I/II(908) 626-5428

picoplatin(orphan Drug)

Ponaird PharmaceuticalsSeattle, WA

second-line SCLC(Fast Track)(see also colorectal, ovarian, prostate)

Phase II(206) 281-7001

plinabulin (NPI-2358)

Nereus PharmaceuticalsSan Diego, CA


PRAME antigen-specific cancer immunotherapeutic (recombinant)


NSCLC(see also skin)

Phase I(888) 825-5349

PT107(allogeneic tumor cell vaccine)

Pique TherapeuticsDurham, NC



NSCLC (combination therapy)(see also brain, head/neck, prostate)

Phase II(206) 801-2100

ranpirnase Tamir BiotechnologyMonmouth Junction, NJ



NSCLC(see also colorectal, kidney, solid tumors, stomach)

Phase I(888) 842-2837

Reolysin®


NSCLC (combination therapy)(see also brain, colorectal, head/neck, ovarian, pancreatic, sarcoma, skin, solid tumors)

Phase II(403) 670-7377

retaspimycin Infinity PharmaceuticalsCambridge, MA


RG7414(EGFL7 inhibitor)


NSCLC(see also colorectal)

Phase II(800) 626-3553



lung CanCer


RG7599(antibody drug conjugate)



Phase I(800) 626-3553


NSCLC(see also breast, kidney, prostate, sarcoma, other)

Phase II(800) 672-6372

sapacitabine (CYC682)


NSCLC(see also leukemia, solid tumors)

Phase II(908) 517-7330



NSCLC(see also breast, ovarian)

Phase II(800) 981-2491

talactoferrin alfa (oral)(orphan Drug)

AgennixPrinceton, NJ

NSCLC(Fast Track)

Phase III(609) 524-1000

tamibarotene CytRxLos Angeles, CA

NSCLC(see also leukemia)

Phase II(310) 826-5648

tarceva®


adjuvant NSCLC (see also brain, breast, head/neck, leukemia, liver, other)

Phase III(800) 626-3553(631) 962-0600

tavocept®dimesna

BioNumerik PharmaceuticalsSan Antonio, TX

(see also cancer-related) Phase III(210) 614-1701

Tc-99m ethylenedicysteine glucosamine(EC-G)

Cell PointCentennial, CO

NSCLC (diagnosis) Phase II/III(303) 689-9693

telcyta™canfosfamide

TelikPalo Alto, CA

third-line NSCLC (see also lymphoma, ovarian)

Phase III completed(650) 845-7700

temodar®

temozolomideMerckWhitehouse Station, NJ

SCLC(see also leukemia)

Phase II(800) 672-6372



NSCLC(see also colorectal, kidney, liver, pancreatic, sarcoma, other)

Phase III(781) 994-0300(973) 944-2600



lung CanCer


topotecan liposomes injection Talon TherapeuticsSan Mateo, CA

SCLC(see also ovarian)

Phase I(650) 599-6404


second-line NSCLC (see also leukemia, lymphoma, multiple myeloma, pancreatic, skin)

Phase II(888) 825-5249

Vargatef™intedanib


second-line late-stage NSCLC (combination therapy)(see also ovarian)

Phase III(800) 243-0127



mesothelioma(see also kidney, skin)

Phase I(323) 221-7818

volociximab Abbott LaboratoriesAbbott Park, IL Biogen IdecWeston, MA

NSCLC Phase II(847) 937-6100(781) 464-2000

Xalkori®crizotinib(orphan Drug)

PfizerNew York, NY

first-line ALK-positive NSCLC, second-line ALK-positive NSCLC(see also solid tumors)--------------------------------------------------NSCLC (combination therapy)

Phase III(860) 732-5156

-------------------------------------------Phase I/II(860) 732-5156

YeRVoY®

ipilimumabBristol-Myers SquibbPrinceton, NJ

NSCLC, SCLC(see also prostate, skin)


Zolinza®

vorinostat(orphan Drug)


mesothelioma(see also breast, leukemia, lymphoma, multiple myeloma, other)

Phase III(800) 672-6273

Zybrestat™fosbretabulin

OXiGENESouth San Francisco, CA

first-line NSCLC(see also ovarian)

Phase II(650) 635-7000



lympHoma


abexinostat(HDAC inhibitor)

PharmacyclicsSunnyvale, CA

lymphoma(see also sarcoma)

Phase I/II(408) 774-0330



(see also brain, breast, colorectal, lung, ovarian, prostate, skin, other)

Phase I/II(847) 937-6100

Actimid®


Waldenström’s macroglobulinemia(see also lung, multiple myeloma, pancreatic)

Phase I(908) 673-9000

Adcetris™brentuximab vedotin

Millennium PharmaceuticalsCambridge, MASeattle GeneticsBothell, WA

post-transplant Hodgkin’s lymphoma relapse prevention(see also leukemia)--------------------------------------------------relapsed/refractory CD30-positive non-Hodgkin’s lymphoma, relapsed/refractory anaplastic large-cell lymphoma--------------------------------------------------first-line anaplastic large-cell lymphoma, first-line Hodgkin’s lymphoma

Phase III(800) 390-5663(425) 527-4000-------------------------------------------Phase II(800) 390-5663(425) 527-4000

-------------------------------------------Phase I(800) 390-5663(425) 527-4000

Adcetris™ Companion Diagnosticbrentuximab vedotin companion diagnostic

Millennium PharmaceuticalsCambridge, MASeattle GeneticsBothell, WAVentana Medical SystemsTucson, AZ

cutaneous T-cell lymphoma (diagnosis), T-cell lymphoma (diagnosis)

in clinical trials(617) 679-7000(425) 527-4000(800) 227-2155

AEG35156(XIAP inhibitor)

Aegera TherapeuticsMontreal, Canada

B-cell lymphoma(see also leukemia)

Phase I/II(514) 288-5532

AEZS-112 AEterna Zentaris Basking Ridge, NJ

(see also solid tumors) Phase I(908) 626-5428

Afinitor®


mantle cell lymphoma(see also breast, kidney)

Phase II(888) 669-6682

AFM13 Affimed TherapeuticsHeidelberg, Germany

second-line Hodgkin’s disease Phase Iwww.affimed.com

Alocrest™vinorelbine liposomal


non-Hodgkin’s lymphoma(see also solid tumors)

Phase I(650) 588-6404



lympHoma


AME-133v (ocaratuzumab)

MENTRIK BiotechDallas, TX

non-Hodgkin’s lymphoma Phase II completed(214) 593-0500

Amplimexon®

imexonAmpliMedTucson, AZ

second-line non-Hodgkin’s lymphoma Phase II(520) 529-1000

amuvatinib(MP470)

Astex PharmaceuticalsDublin, OH

(see also lung) Phase I(925) 560-0100

anti-CD22 mAb Abiogen PharmaPisa, Italy

B-cell lymphoma Phase Iwww.abiogen.com

Aplidin®

plitidepsinPharmaMarMadrid, Spain

(see also multiple myeloma, solid tumors)

Phase Iwww.pharmamar.com




(see also leukemia, multiple myeloma)

Phase I/II(862) 703-7170

Arranon®

nelarabine(orphan Drug)


first-line T-cell lymphoma(see also leukemia)--------------------------------------------------second-line T-cell lymphoma

Phase III(888) 669-6682-------------------------------------------Phase I/II(888) 669-6682

Arzerra®

ofatumumabGlaxoSmithKlineRsch. Triangle Park, NC

second-line diffuse large B-cell lymphoma, second-line follicular lymphoma(see also leukemia)--------------------------------------------------Waldenström’s macroglobulinemia

Phase III(888) 825-5249

-------------------------------------------Phase II(888) 825-5249

ASP3026 Astellas Pharma USDeerfield, IL

late-stage B-cell lymphoma(see also solid tumors)

Phase I(800) 695-4321



non-Hodgkin’s lymphoma(see also brain, leukemia, lung, prostate, stomach)

Phase II(610) 408-0301

AT-406/Debio-1143 Ascenta TherapeuticsMalvern, PADebiopharmLausanne, Switzerland

lymphoma (see also leukemia)

Phase I(610) 408-0301www.debiopharm.com



lympHoma




mantle cell lymphoma(see also leukemia, multiple myeloma, solid tumors)

Phase II(925) 560-0100

AT9283(aurora/Jak2 inhibitor)


non-Hodgkin’s lymphoma(see also leukemia, multiple myeloma, solid tumors)

Phase I(925) 560-0100

autologous cancer vaccine Bayer InnovationDusseldorf, GermanyStellar BiotechnologiesPort Hueneme, CA

follicular lymphoma (prevention of relapse)

Phase I(888) 842-2937(805) 488-2800


CelgeneSummit, NJ

second-line non-Hodgkin’s lymphoma, second-line Walden-ström’s macroglobulinemia(see also leukemia, unspecified)

Phase I(908) 673-9000

Bcl-2 inhibitor(ABT-199/GDC-0199)

Abbott LaboratoriesAbbott Park, ILGenentechSouth San Francisco, CA

non-Hodgkin’s lymphoma(see also leukemia)

Phase I(847) 937-6100(800) 626-3553

belinostat(orphan Drug)

Spectrum PharmaceuticalsHenderson, NV

peripheral T-cell lymphoma (PTCL) (Fast Track)(see also colorectal, leukemia, liver, lung, ovarian, other)

Phase II(702) 835-6300

Bexxar®

tositumomab and iodine I-131 tositumomab


mantle cell lymphoma (combination therapy)

Phase II(888) 825-5249

BiovaxID®

B-cell lymphoma vaccine(personalized lymphoma vaccine)

BioVest InternationalTampa, FL

indolent follicular lymphoma (Fast Track)--------------------------------------------------mantle cell lymphoma


CC-115(kinase inhibitor)

CelgeneSummit, NJ

non-Hodgkin’s lymphoma(see also multiple myeloma, solid tumors)

Phase I(908) 673-9000

CC-122 CelgeneSummit, NJ

non-Hodgkin’s lymphoma(see also multiple myeloma, solid tumors)

Phase I(908) 673-9000


CelgeneSummit, NJ

non-Hodgkin’s lymphoma(see also lung, multiple myeloma)

Phase I(908) 673-9000

CEP-9722(PARP inhibitor)

CephalonFrazer, PA

mantle cell lymphoma (combination therapy)(see also lung)

Phase I(610) 344-0200



lympHoma


Clearazide™mechlorethamine gel(orphan Drug)

Ceptaris TherapeuticsMalvern, PA

cutaneous T-cell lymphoma(Fast Track)



diffuse large B-cell lymphoma, second-line follicular lymphoma (combination therapy)(see also colorectal, leukemia)


darinaparsin(ZIO-101)(orphan Drug)


second-line peripheral T-cell lymphoma(see also liver, multiple myeloma, solid tumors)--------------------------------------------------first-line peripheral T-cell lymphoma (combination therapy), non-Hodgkin’s lymphoma

Phase II(646) 214-0700

-------------------------------------------Phase I(646) 214-0700

DCDS-4501A GenentechSouth San Francisco, CA


Phase I(800) 626-3553

DCDT-2980S GenentechSouth San Francisco, CA

recurrent non-Hodgkin’s lymphoma(see also leukemia)

Phase I(800) 626-3553

DI-Leu16-IL2 Alopexx OncologyWaltham, MA

non-Hodgkin’s lymphoma Phase I(781) 497-9888


Hodgkin’s disease(see also breast, colorectal, kidney, leukemia, lung)

Phase II(781) 419-1400

enzastaurin Eli LillyIndianapolis, IN

diffuse large B-cell lymphoma Phase III(800) 545-5979

epratuzumab(orphan Drug)

ImmunomedicsMorris Plains, NJUCBAtlanta, GA

diffuse large B-cell lymphoma (combination therapy), follicular lymphoma (combination therapy)(see also leukemia)

Phase II(973) 605-8200

epratuzumab Y-90 ImmunomedicsMorris Plains, NJ

diffuse large B-cell lymphoma

--------------------------------------------------recurrent non-Hodgkin’s lymphoma




lympHoma


EZN-2968(HIF1-alpha inhibitor)



Folotyn®

pralatrexate(orphan Drug)


peripheral T-cell lymphoma (first-line therapy)(see also bladder, breast, lung)--------------------------------------------------B-cell non-Hodgkin’s lymphoma, lymphoma (combination therapy)--------------------------------------------------cutaneous T-cell lymphoma

Phase III(303) 426-6262

-------------------------------------------Phase II(303) 426-6262-------------------------------------------Phase I(303) 426-6262

forodesine(orphan Drug)

BioCryst PharmaceuticalsDurham, NC

cutaneous T-cell lymphoma(see also leukemia)

Phase II(919) 859-1302

galiximab Biogen IdecCambridge, MA

non-Hodgkin’s lymphoma(combination therapy)--------------------------------------------------first-line non-Hodgkin’s lymphoma(monotherapy)

Phase II completed(617) 679-2000-------------------------------------------Phase I completed(617) 679-2000

GDC-0349(small molecule)



Phase I(800) 626-3553

GDC-0425(ChK1 inhibitor)



GDC-0575 GenentechSouth San Francisco, CA


GDC-0917(IAP antagonist)





non-Hodgkin’s lymphoma(see also breast, solid tumors)

Phase I(800) 626-3553

GS-1101(PI3K delta inhibitor)


indolent non-Hodgkin’s lymphoma(see also leukemia)

Phase II(800) 445-3235

GSK461364(polio-like kinase inhibitor)



Phase I(888) 825-5249

GSK690693(AKT kinase inhibitor)





lympHoma


GSK2126458(PI3K/mTOR inhibitor)






iboctadekin GlaxoSmithKlineRsch. Triangle Park, NC

non-Hodgkin’s lymphoma (combination therapy)(see also ovarian)




diffuse large B-cell lymphoma, mantle cell lymphoma(see also leukemia, multiple myeloma)

Phase II(800) 526-7736(408) 774-0330

IMGN529 ImmunoGenWaltham, MA

metastatic non-Hodgkin’s lymphoma Phase I(781) 895-0600

INK128(mTOR inhibitor)

IntellikineLa Jolla, CA

Waldenström’s macroglobulinemia(see also multiple myeloma, solid tumors)

Phase I(858) 768-6500

inotuzumab ozogamicin PfizerNew York, NY

aggressive non-Hodgkin’s lymphoma(see also leukemia)--------------------------------------------------diffuse large B-cell lymphoma, indolent non-Hodgkin’s lymphoma


interleukin-12 gene therapy OncoSec MedicalSan Diego, CA

cutaneous T-cell lymphoma(see also skin)

Phase IIwww.oncosec.com

ISF35 MemgenSan Diego, CA

follicular lymphoma, diffuse large cell lymphoma, mantle cell lymphoma, small lymphocytic lymphoma(see also leukemia)

Phase II(858) 524-5400

JNJ-26481585(quisinostat)


cutaneous T-cell lymphoma(see also leukemia)

Phase II(800) 817-5286

LEE011(CDK4/6 inhibitor)



LG740(activated T-cells)

LentigenGaithersburg, MDUniversity of PennsylvaniaPhiladelphia, PA

diffuse large B-cell lymphoma, follicular lymphoma, mantle-cell lymphoma(see also leukemia)

Phase I(301) 527-4200



lympHoma


lucatumumab(HDC122)


lymphoma

--------------------------------------------------follicular lymphoma

Phase I/II(888) 669-6682-------------------------------------------Phase I(888) 669-6682

Marqibo®

vincristine liposomalTalon TherapeuticsSan Mateo, CA

non-Hodgkin’s lymphoma(see also leukemia, skin, other)

Phase II(650) 588-6404


non-Hodgkin’s lymphoma(see also leukemia, multiple myeloma)

Phase I/II(973) 605-8200

MK-7956(dinaciclib)


mantle cell lymphoma(see also leukemia)

Phase II(800) 672-6372


late-stage follicular lymphoma (combination therapy)

Phase I(800) 672-6372

MLN8237(alisertib)

Millennium PharmaceuticalsCambridge, MA

peripheral T-cell lymphoma (see also solid tumors)

Phase III(800) 390-5663

MLN9708(ixazomib)


lymphoma, Waldenström’smacroglobulinemia(see also multiple myeloma, solid tumors)

Phase I(800) 390-5663

mocetinostat(MGCD0103, HDAC inhibitor)(orphan Drug)


diffuse large B-cell lymphoma, follicular lymphoma(see also leukemia, solid tumors)

Phase II(514) 337-3333

mogamulizumab(orphan Drug)


cutaneous T-cell lymphoma, peripheral T-cell lymphoma

Phase II(800) 772-6436

navitoclax(ABT-263)


(see also leukemia, lung) Phase I/II(847) 937-6100

NPI-0052(marizomib)


(see also multiple myeloma, solid tumors)

Phase I(858) 587-4090

obatoclax(orphan Drug)

CephalonFrazer, PA

first-line follicular lymphoma (combination therapy)(see also leukemia, lung, multiple myeloma)--------------------------------------------------mantle cell lymphoma


-------------------------------------------Phase I/II completed(610) 344-0200



lympHoma


obinutuzumab(GA101/RG7159)


first-line non-Hodgkin’s lymphoma (combination therapy), second-line non-Hodgkin’s lymphoma (com-bination therapy), first-line B-cell lymphoma (combination therapy)(see also leukemia)--------------------------------------------------second-line non-Hodgkin’s lymphoma (monotherapy)

Phase III(781) 464-2000(800) 626-3553

-------------------------------------------Phase II(781) 464-2000(800) 626-3553

ON 013105 Onconova TherapeuticsNewtown, PA

(see also leukemia) Phase I(267) 759-3680

ONO-4059 ONO PharmaceuticalOsaka, Japan

B-cell lymphoma Phase Iwww.ono.co.jp


(see also leukemia, lung, solid tumors)

Phase I(908) 673-9000

OSI-027(TORC1/TORC2 inhibitor)


(see also kidney) Phase I(631) 962-0600

P 27600 Piramal Life SciencesMumbai, India

mantle cell lymphoma Phase IIwww.piramallifesciences.com


lymphoma (combination therapy), Waldenström’s macroglobulinemia (see also brain, colorectal, kidney, leukemia, lung, multiple myeloma, sarcoma, solid tumors, stomach)

Phase II(908) 626-5428

PG11047 Progen PharmaceuticalsQueensland, Australia

(see also solid tumors) Phase Iwww.progen-pharma.com

pixantrone Cell TherapeuticsSeattle, WA

diffuse large B-cell lymphoma (see also breast)

Phase III(800) 215-2355



recurrent or refractory Hodgkin’s disease(see also brain, leukemia, solid tumors)

Phase II(510) 647-4000



lympHoma


Revlimid®

lenalidomideCelgeneSummit, NJ


Phase III(908) 673-9000

RG7602 GenentechSouth San Francisco, CA


rigosertib Onconova TherapeuticsNewtown, PA

(see also leukemia, ovarian, pancreatic)

Phase II(267) 759-3680

Rituxan®

rituxumab(fast infusion)


non-Hodgkin’s lymphoma application submitted(781) 464-2000(800) 626-3553

SAR245409 (XL765)(PI3K/mTOR inhibitor)


non-Hodgkin’s lymphoma(see also breast)

Phase II(800) 981-2491(650) 837-7000

SGN-75(vorsetuzumab mafodotin)

Seattle GeneticsBothell, WA

non-Hodgkin’s lymphoma(see also kidney)

Phase I(425) 527-4000

SHP-141 Shape PharmaceuticalsCambridge, MA

cutaneous T-cell lymphoma Phase Iwww.shapepharma.com

sotrastaurin (AEB071)


diffuse large B-cell lymphoma Phase I(888) 669-6682

stem cell therapy Benitec BiopharmaSydney, AustraliaCity of Hope National Medical CenterDuarte, CA

AIDS-related lymphoma Phase Iwww.benitec.com

teglarinad CephalonFrazer, PA



TelikPalo Alto, CA

diffuse large B-cell lymphoma, mantle cell lymphoma, non-Hodgkin’s lymphoma (see also lung, ovarian)

Phase II(650) 845-7700

thiarabine Access PharmaceuticalsDallas, TX

(see also leukemia) Phase I/II(215) 904-5100



lympHoma




(see also breast, colorectal, liver, ovarian, pancreatic)


TKM-PLK1(RNAi)

Tekmira PharmaceuticalsBurnaby, Canada



(see also leukemia, lung, multiple myeloma, pancreatic, skin)

Phase I(888) 825-5249

treanda®


first-line non-Hodgkin’s lymphoma (combination therapy)(see also leukemia, multiple myeloma)--------------------------------------------------second-line mantle cell lymphoma (combination therapy)


-------------------------------------------Phase II(610) 344-0200

TRU-016(humanized anti-CD37 therapeutic)



Phase I/II(301) 795-1800

UNBS-5162 Drais PharmaceuticalsBridgewater, NJ


Velcade®


first-line mantle cell lymphoma(see also leukemia, cancer-related, other)--------------------------------------------------non-Hodgkin’s B-cell lymphoma

--------------------------------------------------diffuse large B-cell lymphoma

Phase III(800) 390-5663

-------------------------------------------Phase III(800) 390-5663-------------------------------------------Phase II(800) 390-5663

veltuzumab ImmunomedicsMorris Plains, NJ


Phase I/II(973) 605-8200

Vidaza®

azacitidineCelgeneSummit, NJ

(see also leukemia) Phase III(908) 673-9000

VTX-2337 VentiRx PharmaceuticalsSeattle, WA

B-cell lymphoma(see also solid tumors)--------------------------------------------------lymphoma

Phase I/II(206) 689-2259-------------------------------------------Phase I(206) 689-2259



lympHoma


XmAb®2513(CD30-antigen inhibitor)

XencorMonrovia, CA

Hodgkin’s disease, T-cell lymphoma Phase I(626) 305-5900

YM155(sepantronium)

Astellas Pharma USDeerfield, IL

non-Hodgkin’s lymphoma(see also breast)

Phase II(800) 695-4321

zanolimumab(orphan Drug)


cutaneous T-cell lymphoma

--------------------------------------------------peripheral T-cell lymphoma

Phase II(301) 795-1800-------------------------------------------Phase I(301) 795-1800

Zevalin®

ibritumomab tiuxetanSpectrum PharmaceuticalsHenderson, NV

second-line diffuse large B-cell lymphoma--------------------------------------------------mantle cell lymphoma


Zolinza®


B-cell lymphoma(see also breast, leukemia, lung, multiple myeloma, other)

Phase II(800) 672-6273

multiple myeloma


ACE-041(dalantercept)

Acceleron PharmaCambridge, MA

(see also head/neck) Phase I(617) 649-9200

Actimid®

pomalidomide(orphan Drug)

CelgeneSummit, NJ

recurrent multiple myeloma(see also lung, lymphoma, pancreatic)


ACY-1215(HDAC6 inhibitor)

Acetylon PharmaceuticalsBoston, MA

Phase I/II(617) 245-1300

ALXN6000(samalizumab)

Alexion PharmaceuticalsCheshire, CT

(see also leukemia) Phase I/II completed(203) 272-2596



multiple myeloma


Aplidin®

plitidepsin(orphan Drug)

PharmaMarMadrid, Spain

(see also lymphoma, solid tumors) Phase IIIwww.pharmamar.com


(see also leukemia, lymphoma) Phase I/II(862) 703-7170



multiple myeloma(see also leukemia, solid tumors)--------------------------------------------------multiple myeloma (combination therapy)

Phase II(877) 633-2436-------------------------------------------Phase I(877) 633-2436



second-line multiple myeloma (see also leukemia, lymphoma, solid tumors)

Phase I/II(925) 560-0100



(see also leukemia, lymphoma, solid tumors)

Phase II(925) 560-0100



(see also breast, colorectal, lung, stomach)

Phase I/II(888) 669-6682

BHQ880(mAb)


(see also solid tumors) Phase II(888) 669-6682

BI-505(orphan Drug)

BioInvent InternationalLund, Sweden

second-line late-stage multiple myeloma

Phase Iwww.bioinvent.com

BIW-8962 Kyowa Hakko Kirin PharmaPrinceton, NJ

Phase I/II(609) 919-1100

carfilzomib(orphan Drug)

Onyx PharmaceuticalsSouth San Francisco, CA

third-line multiple myeloma (Fast Track)(see also solid tumors)--------------------------------------------------multiple myeloma (combination therapy)


-------------------------------------------Phase I/II(650) 266-0000

CB3304 (noscapine)

Cougar BiotechnologyRaritan, NJ

Phase I/IIwww.cougarbiotechnology.com


CelgeneSummit, NJ

(see also lymphoma, solid tumors) Phase I(908) 673-9000




CelgeneSummit, NJ

(see also lung, lymphoma) Phase I(908) 673-9000



multiple myeloma


CP-18770(delanzomib)

CephalonFrazer, PA

Phase II(610) 344-0200

CX-4945(CK2 inhibitor)

Cylene PharmaceuticalsSan Diego, CA


daratumumab GenmabPrinceton, NJ

Phase I/II(609) 430-2481



(see also liver, lymphoma, solid tumors)

Phase II(646) 214-0700

DFRF-4539A GenentechSouth San Francisco, CA

refractory metastatic multiple myeloma

Phase I(800) 626-3553

elotuzumab (BMS-901608)


Phase III(800) 332-2056

ENMD-2076(orphan Drug)

EntreMedRockville, MD

relapsed or refractory multiple myeloma(see also ovarian, other)

Phase I(240) 864-2600

ganetespib (Hsp90i)


second-line multiple myeloma(see also breast, colorectal, leukemia, liver, lung, pancreatic, prostate, skin, stomach)

Phase I(781) 274-8200

GL-0817 GliknikBaltimore, MD

(see also head/neck) Phase IIwww.gliknik.com




GVAX® Myelomacancer vaccine


Phase II(847) 478-0500



(see also leukemia, lymphoma) Phase II(800) 526-7736(408) 774-0330


second-line multiple myeloma (monotherapy)(see also breast, leukemia, lung)

Phase II(650) 473-7700

indatuximab ravtansine(orphan Drug)

BiotestDreieich, Germany

relapsed or refractory multiple myeloma

Phase I/IIwww.biotest.de



multiple myeloma





IPH-2101(anti-KIR mAb)

Innate PharmaMarseille, France

multiple myeloma (monotherapy)

--------------------------------------------------multiple myeloma (combination therapy)

Phase IIwww.innate-pharma.com-------------------------------------------Phase I/IIwww.innate-pharma.com

KW-2478 Kyowa Hakko Kirin PharmaPrinceton, NJ

multiple myeloma (combination therapy)

Phase I/II(609) 919-1100



(see also kidney, leukemia, prostate, solid tumors)

Phase III(888) 669-6682

lorvotuzumab mertansine(IMGN901)

ImmunoGenWaltham, MA



multiple myeloma (combination therapy)(see also liver, lung)

Phase II(301) 309-8504

melphalan intravenous(captisol-enabled)(orphan Drug)

CyDex PharmaceuticalsLenexa, KS

Phase IIwww.ligand.com/cydex


recurrent multiple myeloma(see also leukemia, lymphoma)

Phase I/II(973) 605-8200

MLN9708(ixazomib)


newly diagnosed multiple myeloma (combination therapy), second-line multiple myeloma(see also lymphoma, solid tumors)

Phase I/II(800) 390-5663

Nexavar®


(see also breast, colorectal, head/neck, kidney, leukemia, liver, lung, ovarian, other)

Phase I/II(888) 842-2937

NPI-0052(marizomib)



obatoclax CephalonFrazer, PA

(see also leukemia, lung, lymphoma) Phase I completed(610) 344-0200



multiple myeloma


perifosine(orphan Drug)

AEterna ZentarisBasking Ridge, NJ

recurrent multiple myeloma (combination therapy)(Fast Track)(see also brain, colorectal, kidney, leukemia, lung, lymphoma, sarcoma, solid tumors, stomach)

Phase III(908) 626-5428

RG7444(MFGR-1877S)


refractory metastatic multiple myeloma(see also solid tumors)

Phase I(800) 626-3553



Phase I(800) 626-3553



(see also breast, prostate, sarcoma, other)

Phase I/II(800) 833-3533

SF1126 Semafore PharmaceuticalsIndianapolis, IN

(see also leukemia, solid tumors) Phase I(317) 876-3075

siltuximab Janssen BiotechHorsham, PA

(see also prostate, other) Phase II(800) 526-7736

SNS01-T(nano-encapsulated gene therapy)(orphan Drug)

Senesco TechnologiesBridgewater, NJ

second-line multiple myeloma Phase I/II(908) 864-4444


(see also brain, leukemia, pancreatic, sarcoma)

Phase I/II(650) 474-8200

TKI258(dovitinib)


(see also breast, kidney, prostate, skin, other)

Phase II(888) 669-6682


multiple myeloma (see also leukemia, lung, lymphoma, pancreatic, skin)

Phase I/II(888) 825-5249

treanda®


second-line multiple myeloma (combination therapy)(see also leukemia, lymphoma)

Phase I/II(610) 344-0200

Xgeva™denosumab


(see also cancer-related, other) Phase II(800) 772-6436

Zolinza®

vorinostat(orphan Drug)


metastatic multiple myeloma(see also breast, leukemia, lung, lymphoma, other)

Phase III(800) 672-6273



ovarian CanCer


Å6 Angstrom PharmaceuticalsSolana Beach, CA

(see also other) Phase II(858) 314-2356

abagovomab(anti-idiotype mAb vaccine)(orphan Drug)

MenariniFlorence, Italy

Phase IIIwww.menarini.com

Abraxane®


(see also bladder, breast, lung, pancreatic, skin)

Phase II(908) 673-9000



(see also brain, breast, colorectal, lung, lymphoma, prostate, skin, other)

Phase II(847) 937-6100

AE37 peptide vaccine Antigen ExpressWorcester, MA

(see also breast) Phase I(508) 852-8783

AEZS-108(orphan Drug)

AEterna ZentarisBasking Ridge, NJ

(see also bladder, prostate, other) Phase II(908) 626-5428

Avastin®

bevacizumab(orphan Drug)


relapsed, platinum-sensitive ovarian cancer(see also brain, breast, colorectal, lung, other)--------------------------------------------------first-line metastatic ovarian cancer


-------------------------------------------Phase III(800) 626-3553

BC-819 (gene therapy)(orphan Drug)


late-stage ovarian cancer(see also bladder, pancreatic)

Phase I/IIwww.biocancell.com


late-stage ovarian cancer (combination therapy)(see also colorectal, leukemia, liver, lung, lymphoma, other)


cabozantinib(XL184)


(see also breast, kidney, lung, prostate, other)

Phase II(650) 837-7000

catumaxomab Fresenius Biotech North AmericaWaltham, MA

(see also other) Phase IIwww.fresenius-biotech.com

CVac™MUC-1 cancer vaccine

Prima BioMedSydney, Australia

Phase II/IIIwww.primabiomed.com.au



ovarian CanCer


DCVax®-ovariandendritic cell-based vaccine

Northwest BiotherapeuticsBethesda, MD

Phase I(240) 497-9024

DMUC-5754A GenentechSouth San Francisco, CA

second-line ovarian cancer (see also other)

Phase I(800) 626-3553


(see also breast, prostate) Phase I(902) 492-1819

DPX-survivac cancer vaccine ImmunovaccineHalifax, Canada

Phase I(902) 492-1819

E7850(irofulven)


(see also prostate, other) Phase II(888) 422-4743

EC20(technetium Tc-99m etarfolatide)

EndocyteWest Lafayette, IN

ovarian cancer (diagnosis)(see also lung)

Phase IIIwww.endocyte.com

EC145(vintafolide)

EndocyteWest Lafayette, INMerckWhitehouse Station, NJ

platinum-resistant ovarian cancer(see also lung)

Phase IIIwww.endocyte.com(800) 672-6372

EGEN-001(orphan Drug)

EGENHuntsville, AL

(see also colorectal, other) Phase II(256) 512-0077


(see also leukemia, lung) Phase II(781) 274-8200

ENMD-2076(orphan Drug)

EntreMedRockville, MD

platinum-resistant ovarian cancer(see also multiple myeloma, other)

Phase II(240) 864-2600

etirinotecan pegol (NKTR-102)(orphan Drug)


platinum-resistant ovarian cancer(see also breast, colorectal, solid tumors)

Phase II(855) 482-6587



adjuvant ovarian cancer(see also colorectal, skin)

Phase II(214) 442-8100



(see also breast, other) Phase I/II(855) 855-4253

iboctadekin GlaxoSmithKlineRsch. Triangle Park, NC

(see also lymphoma) Phase I completed(888) 825-5249



ovarian CanCer


IMT-1012 immunotherapeutic vaccine

ImmunotopeDoylestown, PA


iniparib(BSI-201)


(see also breast, lung) Phase II(800) 981-2491

Karenitecin®

cositecanBioNumerik PharmaceuticalsSan Antonio, TX

advanced ovarian cancer(see also lung, solid tumors)

Phase III(210) 614-1701

KHK-2866 Kyowa Hakko Kirin PharmaPrinceton, NJ

ovarian cancer (combination therapy)(see also solid tumors)

Phase I(609) 919-1100

MK-1775(Wee1 inhibitor)


second-line ovarian cancer Phase II(800) 672-6372

MORAb-003(farletuzumab)


platinum-sensitive ovarian cancer(see also lung)

Phase III(888) 422-4743

Nexavar®


first-line ovarian cancer (see also breast, colorectal, head/neck, kidney, leukemia, liver, lung, multiple myeloma, other)

Phase II(888) 842-2937


(see also breast, lung) Phase I(425) 686-1500

olaratumab(LY3012207)





second-line ovarian cancer(see also lung, sarcoma)

Phase II(800) 981-2491



(see also brain, lung, stomach, other) Phase III(800) 215-2355

oregovomab(orphan Drug)

Quest PharmaTechEdmonton, Canada

Phase I/II(780) 448-1400



(see also lung, other) Phase II(631) 962-0600

oVax®

autologous cell vaccine(orphan Drug)

AVAX TechnologiesPhiladelphia, PA

Phase I/II(215) 241-9760



ovarian CanCer


phenoxodiol Marshall EdwardsSan Diego, CA

second-line late-stage ovarian cancer (Fast Track)(see also prostate, other)

Phase III(858) 792-6300


(see also colorectal, lung, prostate) Phase II(206) 281-7001

Quinamed®


(see also breast, prostate) Phase II(610) 344-0200

Reolysin®


ovarian cancer (combination therapy)(see also brain, colorectal, head/neck, lung, pancreatic, sarcoma, skin, solid tumors)--------------------------------------------------ovarian cancer (monotherapy)

Phase II(403) 670-7377

-------------------------------------------Phase I(403) 670-7377


Phase I(800) 626-3553






platinum-resistant ovarian cancer(see also pancreatic)

Phase I(800) 626-3553


(see also leukemia, lymphoma, pancreatic)

Phase II(267) 759-3680

rucaparib Clovis OncologyBoulder, CO

(see also breast) Phase II(303) 625-5000


(see also breast, prostate) Phase II completed(888) 842-2937



(see also breast, lung) Phase I(800) 981-2491

SG2000 SpirogenLondon, United Kingdom

Phase IIwww.spirogen.com

squalamine(orphan Drug)

OHR PharmaceuticalNew York, NY

resistant ovarian cancer Phase II(212) 682-8452


TelikPalo Alto, CA

(see also lung, lymphoma) Phase III completed(650) 845-7700



ovarian CanCer




(see also breast, colorectal, liver, lymphoma, pancreatic)

Phase II(973) 944-2600

topotecan liposomes injection Talon TherapeuticsSan Mateo, CA


trabectedin(orphan Drug)


second-line ovarian cancer(see also breast, prostate, sarcoma)

Phase III(800) 817-5286



(see also breast, prostate, other) Phase II(858) 550-0780

trebananib (AMG386)


(see also breast, colorectal, kidney, liver, stomach, other)

Phase III(800) 772-6436

Vargatef™intedanib


first-line late-stage ovarian cancer (combination therapy)(see also lung)

Phase III(800) 243-0127

vosaroxin Sunesis PharmaceuticalsSouth San Francisco, CA

(see also leukemia) Phase II(650) 266-3739



(see also kidney, other) Phase III(888) 825-5249

Zybrestat™fosbretabulin(orphan Drug)

OXiGENESouth San Francisco, CA


panCreatiC CanCer


Abraxane®

albumin-bound paclitaxel(orphan Drug)

CelgeneSummit, NJ

(see also bladder, breast, lung, ovarian, skin)

Phase III(908) 673-9000

Actimid®


(see also lung, lymphoma, multiple myeloma)

Phase I/II(908) 673-9000



panCreatiC CanCer


anti-MUC1 mAb Quest PharmaTechEdmonton, Canada

Phase I/II(780) 448-1400

anti-PSCA mAb AgensysSanta Monica, CAAstellas Pharma USDeerfield, IL

metastatic pancreatic cancer(combination therapy)

Phase II(800) 695-4321

apricoxib(TG01)

Tragara PharmaceuticalsSan Diego, CA

pancreatic (combination therapy)(see also lung)

Phase II(858) 350-6900

Archexin®

RX-0201(orphan Drug)

Rexahn PharmaceuticalsRockville, MD

metastatic pancreatic cancer (combination therapy)

Phase II(240) 268-5300

ASG-5ME AgensysSanta Monica, CASeattle GeneticsBothell, WA

metastatic pancreatic cancer(see also prostate)

Phase I(800) 695-4321(425) 527-4000


first-line pancreatic cancer (see also liver, lung)

Phase II(715) 508-6000

BAY 86-9766(MEK inhibitor)

Ardea BiosciencesSan Diego, CABayer HealthCare PharmaceuticalsWayne, NJ

first-line pancreatic cancer (combination therapy)(see also liver)

Phase I/II(888) 842-2937

BC-819 (gene therapy)(orphan Drug)


first-line late-stage pancreatic cancer(combination therapy) (Fast Track)(see also bladder, ovarian)

Phase IIwww.biocancell.com

Chk1 inhibitor(LY2603618)



CO-101(lipid drug conjugate of gemcitabine)(orphan Drug)

Clovis OncologyBoulder, CO

first-line metastatic pancreatic cancer, second-line metastatic pancreatic cancer

Phase II(303) 625-5000

CO-101companion diagnostic(hENT1 IHC assay)

Clovis OncologyBoulder, COVentana Medical SystemsTucson, AZ

pancreatic cancer (diagnosis) in clinical trials(303) 625-5000

CPI-613(orphan Drug)

Cornerstone PharmaceuticalsCranbury, NJ

combination therapy(see also other)

Phase I/II(609) 409-7050



panCreatiC CanCer


CRS-207(cancer vaccine)

Aduro BioTechBerkeley, CA

metastatic pancreatic cancer(combination therapy)

Phase II(510) 848-4400



(see also breast, lung, other) Phase I/II(800) 672-6372



refractory metastatic pancreatic cancer(see also colorectal, prostate)

Phase II(212) 746-1566

FG-3019(connective tissue growth factor)

FibroGenSan Francisco, CA

Phase II(415) 978-1200

ganetespib (Hsp90i)


(see also breast, colorectal, leukemia, liver, lung, multiple myeloma, prostate, skin, stomach)

Phase II(781) 274-8200

ganitumab(AMG 479)


first-line metastatic pancreatic cancer(combination therapy)(see also breast, colorectal, lung, sarcoma)

Phase III(800) 772-6436

GI-4000 GlobeImmuneLouisville, CO

(see also colorectal, lung) Phase II(303) 625-2700

glufosfamide(orphan Drug)

Eleison PharmaceuticalsPrinceton, NJ

pancreatic cancer (Fast Track) Phase III completed(215) 554-3530

GS-6624(monoclonal antibody)



GV1001 (hTERT RNA vaccine)

KAEL-GemVaxSeoul, South Korea

Phase Iwww.kaelgemvax.com

GVAX® pancreaticcancer vaccine(orphan Drug)

BioSante PharmaceuticalsLincolnshire, ILAduro BioTechBerkeley, CA

Phase II(847) 478-0500(510) 848-4400

HyperAcute® pancreasalgenpantucel-L(orphan Drug)


Phase III(515) 296-5555

IMP321 ImmutepChâtenay-Malabry, France

Phase Iwww.immutep.org

INNO-206(orphan Drug)


pancreatic ductal adenocarcinoma(see also sarcoma, solid tumors)

Phase II(310) 826-5648



panCreatiC CanCer


Istodax®


(see also kidney, prostate, other) Phase I/II(908) 673-9000

Jakafi™ruxolitinib

Incyte Wilmington, DE

(see also other) Phase II(855) 446-2983

KD032(ras/mTOR inhibitor)


(see also lung) Phase I/II completed(724) 778-6100

LDE225(erismodegib)


neoadjuvant pancreatic cancer(see also leukemia, solid tumors, skin)

Phase I/II(888) 669-6682

LE-DT(liposomal docetaxel)

Insys TherapeuticsPhoenix, AZ

first-line pancreatic cancer Phase II(602) 910-2617

M402(low molecular weight heparin)

Momenta PharmaceuticalsCambridge, MA

metastatic pancreatic cancer Phase I/II(617) 491-9700

masitinib AB Science USAShort Hills, NJ

(see also stomach) Phase III(973) 218-2437

MM-398(nanotherapeutic)(orphan Drug)


metastatic pancreatic cancer Phase II(617) 441-1000


(see also kidney, lung) Phase I completedwww.activebiotech.com

NPC-1C(ensituximab)(orphan Drug)

Neogenix OncologyRockville, MD

late-stage, metastatic pancreatic cancer(see also colorectal)

Phase I(301) 917-6893

paclitaxel polymeric micelle formulation

Samyang BiopharmaceuticalsSeoul, South Korea

late-stage pancreatic cancer Phase IIwww.samyangpharm.com

pancAtak™gene therapy


Phase I(617) 916-5445

PCI-27483(factor VIIa inhibitor)


metastatic pancreatic cancer (combination therapy)

Phase II(408) 774-0330

PEGPH20(pegylated recombinant human hyaluronidase)

Halozyme TherapeuticsSan Diego, CA

Phase I/II(858) 794-8889



panCreatiC CanCer



(see also colorectal, liver, cancer-related)

Phase I/II(203) 777-3462

polyclonal antibody stimulator(orphan Drug)

Cancer AdvancesDurham, NC

(see also colorectal, stomach) Phase III(919) 361-2162

Reolysin®


pancreatic cancer (combination therapy)(see also brain, colorectal, head/neck, lung, ovarian, sarcoma, skin, solid tumors)

Phase II(403) 670-7377

Rexin-G®

(orphan Drug)Epeius BiotechnologiesSan Marino, CA

metastatic pancreatic cancer(Fast Track)(see also breast, sarcoma)

Phase I/II(626) 441-6695



platinum-resistant pancreatic cancer(see also ovarian)

Phase I(800) 626-3553


(see also leukemia, lymphoma, ovarian)

Phase II/III(267) 759-3680

RP101 RESprotectDresden, Germany

Phase II/IIIwww.resprotect.de

SecreFlo™synthetic human secretin

RepligenWaltham, MA

pancreatic cancer (diagnosis) Phase 0(781) 250-0111

SpRYCeL®


(see also brain, breast, prostate, other)



(see also brain, leukemia, multiple myeloma, sarcoma)

Phase II(650) 474-8200



(see also breast, colorectal, liver, lymphoma, ovarian)




(see also colorectal, kidney, liver, lung, sarcoma, other)

Phase I(781) 994-0300(973) 944-2600


first-line pancreatic cancer (see also leukemia, lung, lymphoma, multiple myeloma, skin)

Phase II(888) 825-5249

uridine triacetate (PN401)

Wellstat TherapeuticsGaithersburg, MD

(see also stomach) Phase III(240) 631-2500



panCreatiC CanCer


Virulizin® Lorus TherapeuticsToronto, Canada

Phase III(416) 798-1200

Y-90 clivatuzumab(orphan Drug)


first-line pancreatic cancer (Fast Track)

Phase I/II(973) 605-8200

prostate CanCer


99mTc-MIP-1405 Molecular Insight PharmaceuticalsCambridge, MA

prostate cancer (diagnosis) Phase I(617) 492-5554

ABI-008(nab®-docetaxel)

CelgeneSummit, NJ

first-line hormone-refractory prostate cancer

Phase I/II(908) 673-9000



(see also brain, breast, colorectal, lung, lymphoma, ovarian, skin, other)

Phase I(847) 937-6100


(see also bladder, ovarian, other) Phase II(908) 626-5428

anti-OX40 mAb AgonOxPortland, OR

Phase I(800) 979-7202

AP1903 Bellicum PharmaceuticalsHouston, TX

(see also cancer-related) Phase I/II(713) 341-6472

Apatone®

ascorbic acid/menadioneIC-MedTechSan Diego, CA

Phase I/II(619) 749-6500

APC-100 Adamis PharmaceuticalsSan Diego, CA

Phase I/IIwww.adamispharmaceuticals.com


hormone-refractory prostate cancer(see also brain, breast, skin)

Phase II(646) 747-9090

ARN-509 Aragon PharmaceuticalsSan Diego, CA

hormone-refractory prostate cancer Phase I/II(858) 369-7600



prostate CanCer



castration-resistant prostate cancer(see also pancreatic)

Phase I(800) 695-4321(425) 527-4000



hormone-refractory prostate cancer (combination therapy)(see also brain, leukemia, lung, lymphoma, stomach)--------------------------------------------------hormone-sensitive prostate cancer

Phase II(610) 408-0301

-------------------------------------------Phase I(610) 408-0301

AZD3514(androgen receptor down-regulator)


Phase I(800) 236-9933

bafetinib CytRx Los Angeles, CA

second-line metastatic hormone-refractory prostate cancer(see also brain, leukemia)

Phase II(310) 826-5648

BPX-101(dendritic cell vaccine)

Bellicum PharmaceuticalsHouston, TX

Phase I/II(713) 341-6472

cabozantinib(XL184)


castration-resistant prostate cancer (see also breast, kidney, lung, ovarian, other)

Phase III(650) 837-7000

CBLC102(mepacrine)

Cleveland BioLabsBuffalo, NYIncuronMoscow, Russia

hormone-refractory prostate cancer Phase II completed(716) 849-6810

CD1089 (seocalcitol)

Cougar BiotechnologyRaritan, NJ

Phase Iwww.cougarbiotechnology.com

cilengitide EMD SeronoRockland, MA

(see also brain) Phase III(800) 283-8088

custirsen(OGX-011/TV-1011)

OncoGenex PharmaceuticalsBothell, WATeva PharmaceuticalsTikva, Israel

first-line prostate cancer (combina-tion therapy), second-line hormone-refractory prostate cancer (combina-tion therapy) (Fast Track)(see also lung)

Phase III(425) 686-1500

CYT-500 EUSA PharmaLanghorne, PA

Phase I(800) 833-3533


(see also breast, ovarian) Phase I(902) 492-1819



prostate CanCer


DSTP-3086S GenentechSouth San Francisco, CA

metastatic hormone-refractory prostate cancer

Phase I(800) 626-3553

E7850(irofulven)


hormone-refractory prostate cancer(see also ovarian, other)

Phase II(888) 422-4743

EMD-525797(anti-integrin mAb)


metastatic castration-resistant prostate cancer

Phase II/III(800) 283-8088

emepepimut-S EMD SeronoRockland, MAOncothyreonSeattle, WA

newly-diagnosed prostate cancer(see also lung)

Phase II(800) 283-8088



refractory metastatic prostate cancer(see also colorectal, pancreatic)

Phase II(212) 746-1566

enzalutamide(MDV3100)

Astellas PharmaTokyo, JapanMedivationSan Francisco, CA

hormone-refractory prostate cancer(Fast Track)

Phase III(415) 543-3470

EPO-806(patupilone)



EZN-4176(antisense oligonucleotide)


Phase I(973) 980-4500

Firmagon®

degarelixFerring PharmaceuticalsParsippany, NJ

3-month formulation

--------------------------------------------------neoadjuvant therapy

Phase III(973) 796-1600-------------------------------------------Phase III(973) 796-1600

ganetespib (Hsp90i)


second-line hormone-refractory prostate cancer(see also breast, colorectal, leukemia, liver, lung, multiple myeloma, pancreatic, skin, stomach)

Phase II(781) 274-8200

Gleevec®


hormone-refractory prostate cancer(see also lung, skin, other)

Phase II(888) 669-6682

GRNVAC1(dendritic cell vaccine)

Argos TherapeuticsDurham, NCGeronMenlo Park, CA




prostate CanCer


GTx-758(selective estrogen receptoralpha agonist)

GTxMemphis, TN

first-line advanced prostate cancer,second-line advanced prostate cancer

Phase II(901) 523-9700

GVAX® prostatecancer vaccine

BioSante PharmaceuticalsLincolnshire, ILAduro BioTechBerkeley, CA

(Fast Track) Phase III(847) 478-0500(510) 848-4400

Halaven®


(see also lung, sarcoma) Phase II(888) 422-4743

HE3235 Harbor TherapeuticsSan Diego, CA

hormone-refractory prostate cancer Phase I/II(858) 587-9333

intetumumab Janssen BiotechHorsham, PA

(see also skin) Phase II completed(800) 526-7736

IRX4204 Io TherapeuticsSanta Ana, CA

Phase IIwww.io-therapeutics.com

ISIS-EIF4ERx Isis PharmaceuticalsCarlsbad, CA

prostate cancer (combination therapy)(see also lung)

Phase II(800) 679-4747

Istodax®


(see also kidney, pancreatic, other) Phase II(908) 673-9000

J 591 Lu-177(anti-PMSA mAb)

BZL BiologicsNew York, NY

metastatic prostate cancer, non-metastatic prostate cancer

Phase II(212) 315-5575



(see also lung, solid tumors) Phase I(800) 817-5286

KX2-391 Kinex PharmaceuticalsBuffalo, NY




(see also kidney, leukemia, multiple myeloma, solid tumors)

Phase II(888) 669-6682

LFA102(anti-prolactin receptor antibody)




metastatic prostate cancer(see also breast, colorectal, kidney, leukemia)

Phase II(416) 798-1200



prostate CanCer


MER-104(GnRH antagonist)

Merrion PharmaceuticalsWilmington, DE

Phase I(910) 799-1847

MVA-BN® pRoantigen cancer vaccine


Phase I/II(650) 681-4660

NeuVax™cancer vaccine E75


(see also breast) Phase I/II(855) 855-4253

nimotuzumab YM Biosciences USALehigh Valley, PA

(see also brain, breast) Phase II(610) 560-0600

NX-1207 Nymox PharmaceuticalQuebec, Canada

Phase II(800) 936-9669

ODM-201(androgen receptor antagonist)

Endo PharmaceuticalsChadds Ford, PAOrionEspoo, Finland

castration-resistant prostate cancer Phase II(800) 462-3636

oncolytic virus CZ BioMedTampa, FL

Phase I(813) 600-4088

Onyvax-105anti-idiotype cancer vaccine 105AD7

VaxOncoSeoul, South Korea

Phase IIwww.vaxonco.com

Onyvax-P(prostate cancer vaccine)

VaxOncoSeoul, South Korea

Phase II

ozarelix Spectrum PharmaceuticalsHenderson, NV

hormone-dependent prostate cancer Phase II(702) 835-6300



prostate cancer (combination therapy)(see also liver, skin, other)

Phase I(858) 452-6688


prostate cancer (Fast Track)(see also ovarian, other)



(see also colorectal, lung, prostate) Phase II(206) 281-7001

prostAtak™gene therapy


adjuvant prostate cancer(Fast Track)

Phase III(617) 916-5445



prostate CanCer


prostate cancer vaccine(anti-GnRH)

Novartis Vaccines & DiagnosticsCambridge, MA Pepscan TherapeuticsLelystad, Netherlands

Phase I/II(617) 871-7000

prostvac™rilimogene galvacirepvec

BM ImmunoTherapeuticsMountain View, CA

castration-resistant prostate cancer(Fast Track)

Phase III(650) 681-4660

provenge®

sipuleucel-TDendreonSeattle, WA

recurrent early-stage prostate cancer

--------------------------------------------------neoadjuvant early-stage prostate cancer


PRX-302 Sophiris BioLa Jolla, CA

Phase II(858) 777-1760

PSMA ADC(anti-drug conjugate)

Progenics PharmaceuticalsTarrytown, NY

Phase I(914) 789-2800

PSMA protein vaccine(recombinant soluble)

Progenics PharmaceuticalsTarrytown, NY

Phase I(914) 789-2800

PSMA VRP therapeutic vaccine Progenics PharmaceuticalsTarrytown, NY

Phase I(914) 789-2800


hormone-refractory prostate cancer(see also brain, head/neck, lung)

Phase II(206) 801-2100

Quinamed®


(see also breast, ovarian) Phase II(610) 344-0200

REIC gene therapy Momotaro-GeneOkayama, Japan

Phase Iwww.mt-gene.com


(see also breast, kidney, lung, sarcoma, other)

Phase II(800) 672-6372


(see also breast, ovarian) Phase II completed(888) 842-2937

samarium SM-153 lexidronam injection


(see also breast, multiple myeloma, sarcoma, other)

Phase II(800) 833-3533


hormone-refractory prostate cancer(see also multiple myeloma, other)

Phase I(800) 526-7736



prostate CanCer


SpRYCeL®


(see also brain, breast, pancreatic, other)


TAK-448(KISS1R protein agonist)


Phase I(800) 390-5663

TAK-700 (orteronel)


first-line metastatic prostate cancer (combination therapy), second-line metastatic prostate cancer(combination therapy)--------------------------------------------------prostate cancer

Phase III(800) 390-5663

-------------------------------------------Phase II(800) 390-5663

tasquinimod(TASQ)

Active BiotechLund, Sweden

metastatic prostate cancer

--------------------------------------------------second-line metastatic prostate cancer

Phase IIIwww.activebiotech.com-------------------------------------------Phase Iwww.activebiotech.com

teloB-Vaxtelomerase cancer vaccine

Adamis PharmaceuticalsSan Diego, CA

Phase Iwww.adamispharmaceuticals.com


(see also bladder, breast, skin, stomach)

Phase II(908) 286-9800

tigapotide Kotinos PharmaceuticalsNew York, NY

hormone-refractory prostate cancer Phase II(212) 935-3000

TKI258(dovitinib)


(see also breast, kidney, multiple myeloma, skin, other)

Phase II(888) 669-6682



(see also head/neck, skin, stomach) Phase I(877) 943-6832

TOK-001 Tokai PharmaceuticalsCambridge, MA

castration-resistant prostate cancer Phase I(617) 225-4305

trabectedin Johnson & Johnson PharmaceuticalResearch & DevelopmentRaritan, NJ

(see also breast, ovarian, sarcoma) Phase II(800) 817-5286



(see also breast, ovarian, other) Phase I/II(858) 550-0780



prostate CanCer


trofex™iofolastat I-124

Molecular Insight PharmaceuticalsCambridge, MA

prostate cancer (diagnosis) Phase I(617) 491-5554

troVax®

tumor-associated antigen vaccine

Oxford BioMedicaOxford, United Kingdom

hormone-refractory prostate cancer(combination therapy)

Phase IIwww.oxfordbiomedica.co.uk

VT-464 Viamet PharmaceuticalsMorrisville, NC

Phase I/II(919) 467-8539

YeRVoY®


prostate cancer (post-hormonal therapy), prostate cancer (post-chemotherapy)(see also lung, skin)


Zaltrap™aflibercept


first-line androgen-independent prostate cancer(see also colorectal)

Phase III(914) 345-7400(800) 981-2491

Zytiga®

abirateroneJanssen BiotechHorsham, PA

first-line metastatic prostate cancer(see also breast)--------------------------------------------------neoadjuvant prostate cancer


sarComa



soft tissue sarcoma(see also brain, other)

Phase I(301) 608-9292

abexinostat(HDAC inhibitor)


sarcoma(see also lymphoma)

Phase I/II(408) 774-0330



(see also colorectal, liver) Phase II(800) 332-2056

cancer vaccine MabVax TherapeuticsSan Diego, CA


ganitumab(AMG 479)


(see also breast, colorectal, lung, pancreatic)

Phase II(800) 772-6436

Halaven®


(see also lung, prostate) Phase III(888) 422-4743



sarComa


INNO-206(orphan Drug)


soft tissue sarcoma(see also pancreatic, solid tumors)

Phase II(310) 826-5648

Junovan™mifamurtide(orphan Drug)


osteosarcoma Phase III(800) 390-5663



(see also lung, ovarian) Phase III(800) 981-2491

palifosfamide(ZIO-201)(orphan Drug)


first-line soft tissue sarcoma (combination therapy)(see also lung, solid tumors)--------------------------------------------------second-line soft tissue sarcoma (combination therapy)--------------------------------------------------soft tissue sarcoma (monotherapy)

Phase III(646) 214-0700

-------------------------------------------Phase II(646) 214-0700-------------------------------------------Phase I/II(646) 214-0700


(see also brain, colorectal, kidney, leukemia, lung, lymphoma, multiple myeloma, solid tumors, stomach)

Phase II(908) 626-5428


Ewing’s sarcoma(see also cervical, other)

Phase IIwww.pharmamar.com

Reolysin®


(see also brain, colorectal, head/neck, lung, ovarian, pancreatic, skin, solid tumors)

Phase II(403) 670-7377

Rexin-G®

(orphan Drug)Epeius BiotechnologiesSan Marino, CA

osteosarcoma(see also breast, pancreatic)--------------------------------------------------soft tissue sarcoma


ridaforolimus(orphan Drug)

ARIAD PharmaceuticalsCambridge, MAMerckWhitehouse Station, NJ

metastatic sarcoma (Fast Track)(see also breast, kidney, lung, prostate, other)--------------------------------------------------sarcoma

application submitted(800) 672-6372(626) 441-6695-------------------------------------------Phase II(800) 672-6372(626) 441-6695


osteosarcoma, sarcoma(see also colorectal, solid tumors)

Phase II(800) 672-6372



sarComa




osteosarcoma(see also breast, multiple myeloma, prostate, other)

Phase I/II(800) 833-3533

saridegib(orphan Drug)

Infinity PharmaceuticalsCambridge, MA

chondrosarcoma (inoperable/unresectable)

Phase II(617) 453-1000

TH-302(orphan Drug)

Threshold PharmaceuticalsSouth San Francisco, CA

soft tissue sarcoma(see also brain, leukemia, multiple myeloma, pancreatic)

Phase III(650) 474-8200

tivantinib (ARQ 197)(orphan Drug)


soft tissue sarcoma(see also colorectal, kidney, liver, lung, pancreatic, other)

Phase II(781) 994-0300(973) 944-2600

trabectedin(orphan Drug)


soft tissue sarcoma(see also breast, ovarian, prostate)--------------------------------------------------soft tissue sarcoma (adolescents and children)


skin CanCer


Abraxane®

albumin-bound paclitaxel(orphan Drug)

CelgeneSummit, NJ

malignant melanoma(see also bladder, breast, lung, ovarian, pancreatic)

Phase III(908) 673-9000



malignant melanoma(see also brain, breast, colorectal, lung, lymphoma, ovarian, prostate, other)

Phase II(847) 937-6100

Ad-IL-12 DNA therapeutic(INXN-2001)


malignant melanoma Phase I(646) 214-0700

Allovectin®

velimogene aliplasmid(orphan Drug)

VicalSan Diego, CA

first-line malignant melanoma Phase III(858) 646-1100



skin CanCer


ALT-801 Altor BioScienceMiramar, FL

malignant melanoma(see also other)

Phase I/II(954) 443-8600



melanoma(see also kidney, lung)

Phase II(800) 332-2056

APN301(ch14.18 mAb/interleukin-2 fusion protein)

Apeiron BiologicsVienna, Austria

malignant melanoma(see also brain)

Phase IIwww.apeiron-biologics.com


malignant melanoma (combination therapy)(see also brain, breast, prostate)

Phase II(646) 747-9090

ARRY-162(MEK inhibitor)


malignant melanoma (BRAFV600E or NRAS mutations) (see also solid tumors)

Phase II(877) 633-2436

astuprotimut-R(MAGE-A3 antigen-specific cancer immunotherapeutic)


malignant melanoma(see also lung)--------------------------------------------------inoperable/unresectable malignant melanoma


autologous stem cell therapy California Stem CellsIrvine, CA

malignant melanoma Phase II(949) 534-9149

c31510 CytotechNatick, MA

basal cell cancer, squamous call cancer

Phase II(615) 515-5438

Cavatak™coxsackievirus A21(orphan Drug)

ViralyticsPymble, Australia

malignant melanoma Phase IIwww.viralytics.com

CB-10-01cancer vaccine

Cosmo PharmaceuticalsLainate, Italy

malignant melanoma Phase IIwww.cosmopharmaceuticals.com

CDX-011(glembatumumab vedotin)


malignant melanoma(see also breast)

Phase II(781) 433-0771

CYT107(interleukin-7)

CytherisRockville, MD

malignant melanoma(see also kidney)

Phase I(301) 231-0451

DC-IL-12 DNA therapeutic(INXN-3001)



DEDN-6526A GenentechSouth San Francisco, CA




skin CanCer


dendritic cancer cell vaccine EMD MilliporeBillerica, MA



late-stage malignant melanoma(see also brain, head/neck, liver, solid tumors, stomach)

Phase I/II(888) 422-4743

E7080(lenvatinib)


melanoma(see also brain, other)

Phase II(888) 422-4743

ecromeximab Life Science PharmaceuticalsDarien, CT

malignant melanoma (combination therapy)

Phase II(203) 656-2500

erivedge™vismodegib


early-stage basal cell cancer (resectable)

Phase II(800) 626-3553



malignant melanoma(see also colorectal, ovarian)

Phase II(214) 442-8100

ganetespib (Hsp90i)


malignant melanoma(see also breast, colorectal, leukemia, liver, lung, multiple myeloma, pancreatic, prostate, stomach)

Phase II(781) 274-8200

GDC-0973(MEK inhibitor)


second-line metastatic malignant melanoma (combination therapy) (see also solid tumors)

Phase I(800) 626-3553

Gleevec®


malignant melanoma(see also lung, prostate, other)

Phase II(888) 669-6682



first-line BRAF mutation-positive late-stage malignant melanoma(see also brain, lung)

--------------------------------------------------BRAF mutation-positive metastatic malignant melanoma (combination therapy)

Phase III(888) 825-5249

-------------------------------------------Phase II(888) 825-5249

GSK2241658A(cancer vaccine)


metastatic malignant melanoma Phase I(888) 825-5249

GSK2302025A(cancer vaccine)


first-line metastatic malignant melanoma

Phase I(888) 825-5249



skin CanCer


HyperAcute® Melanomamelanoma vaccine



IMC-gp100(cancer vaccine)

ImmunocoreOxon, United Kingdom

malignant melanoma Phase 0www.immunocore.com


malignant melanoma(see also colorectal, leukemia, lung)

Phase I(651) 675-0300

INCB24360 IncyteWilmington, DE

malignant melanoma(see also solid tumors)

Phase II(855) 446-2983

interleukin-12 gene therapy OncoSec MedicalSan Diego, CA

malignant melanoma, merkel cell carcinoma(see also lymphoma)

Phase IIwww.oncosec.com

intetumumab Janssen BiotechHorsham, PA

malignant melanoma(see also prostate)

Phase I/II(800) 526-7736

LDE225(erismodegib)


basal cell cancer(see also leukemia, pancreatic, solid tumors)

Phase II(888) 669-6682

LGK974(WNT signaling pathway inhibitor)


malignant melanoma(see also breast)

Phase I(888) 669-6682

LGX818(RAF inhibitor)


metastatic malignant melanoma(see also colorectal)

Phase I(888) 669-6682

Lymphoseek®


malignant melanoma (diagnosis)(see also breast, head/neck)


M-200 prophage cancer vaccine(vitespen)(orphan Drug)

AgenusLexington, MA

metastatic melanoma(Fast Track)

Phase III(781) 674-4400

Marqibo®

vincristine liposomal(orphan Drug)


malignant melanoma(see also leukemia, lymphoma, other)

Phase II(650) 588-6404

melanoma DNA vaccine Ichor Medical SystemsSan Diego, CAMemorial Sloan-Kettering Cancer CenterNew York, NY


MORAb-004 EisaiWoodcliff Lake, NJ




skin CanCer


muparfostat (PI-88)(orphan Drug)

Progen PharmaceuticalsQueensland, Australia

malignant melanoma(see also liver)

Phase IIwww.progen.com.au

MVax®

melanoma vaccineAVAX TechnologiesPhiladelphia, PA

malignant melanoma Phase III(215) 241-9760

NX-101 NexGenixNew York, NY

dermal neurofibromatoses Phase II(212) 974-3006

ontak®

denileukin diftitoxEisaiWoodcliff Lake, NJ




metastatic malignant melanoma (see also liver, prostate, other)

Phase II(858) 452-6688

picato®

ingenol mebutateLEO PharmaParsippany, NJ

basal cell cancer Phase II(877) 494-4536

POL-103A(melanoma vaccine)(orphan Drug)

PolynomaSan Diego, CA


PRAME antigen-specific cancer immunotherapeutic (recombinant)


metastatic malignant melanoma(see also lung)

Phase I(888) 825-5349

PTI-188 Pain TherapeuticsAustin, TX

malignant melanoma Phase I completed(512) 501-2444

PV-10(rose bengal sodium)(orphan Drug)

Provectus PharmaceuticalsKnoxville, TN



RAF265(raf kinase inhibitor)


malignant melanoma(see also solid tumors)

Phase I(888) 669-6682

Reolysin®


malignant melanoma(see also brain, colorectal, head/neck, lung, ovarian, pancreatic, sarcoma, solid tumors)

Phase II(403) 670-7377

RG7256(BRAF kinase inhibitor)

RocheNutley, NJ



RocheNutley, NJ




skin CanCer


talminogene laherparepvec AmgenThousand Oaks, CA


tasigna®

nilotinibNovartis PharmaceuticalsEast Hanover, NJ

malignant melanoma (c-Kit mutation)(see also leukemia, stomach)

Phase III(888) 669-6682

tesetaxel(orphan Drug)

GentaBerkeley Heights, NJ

malignant melanoma(see also bladder, breast, prostate, stomach)

Phase II(908) 286-9800

TKI258(dovitinib)


malignant melanoma(see also breast, kidney, multiple myeloma, prostate, other)

Phase I/II(888) 669-6682



malignant melanoma(see also head/neck, prostate, stomach)

Phase II(877) 943-6832


malignant melanoma (monotherapy)(see also leukemia, lung, lymphoma, multiple myeloma, pancreatic)--------------------------------------------------malignant melanoma (combination therapy)

Phase III(888) 825-5249

-------------------------------------------Phase II(888) 825-5249



Kaposi’s sarcoma(see also lung, kidney)

Phase I(323) 221-7818

YeRVoY®


melanoma (adjuvant therapy),melanoma brain metastases(see also lung, prostate)


Zadaxin®

thymalfasin alfa 1(orphan Drug)

SciClone PharmaceuticalsFoster City, CA


Phase II/III(650) 358-3456

solid tumors


AbGn-7 AbGenomicsLos Altos, CA

Phase I(650) 988-9912

ABI-009(sirolimus albumin bound)

CelgeneSummit, NJ

Phase I(908) 673-9000



solid tumors


ABT-348(aurora kinase inhibitor)


late-stage solid tumors(see also other)

Phase I(847) 937-6100

ABT-700(c-Met inhibitor)


Phase I(847) 937-6100

ABT-767(PARP inhibitor)


Phase I(847) 937-6100

ABT-806(EGFR inhibitor)


Phase I(847) 937-6100

AC220(quizartinib)

Ambit BiosciencesSan Diego, CAAstellas Pharma USDeerfield, IL

(see also leukemia) Phase I(858) 334-2100(800) 695-4321

AEZS-112 AEterna Zentaris Basking Ridge, NJ

(see also lymphoma) Phase I(908) 626-5428

AI-850 AcusphereLexington, MA

Phase I(617) 648-8800

ALB-109564(a)(tubulin inhibitor)

AMRIAlbany, NYBessor PharmaFramingham, MA

Phase Iwww.amriglobal.com

AlloStim™ Immunovative TherapiesShoham, Israel

(see also other) Phase I/IIwww.immunovative.co.il

Alocrest™vinorelbine liposomal



AMG 208(c-Met inhibitor)


Phase I(800) 772-6436

AMG 337(c-Met inhibitor)


Phase I(800) 772-6436

AMG 780(angioprotein inhibitor)


Phase I(800) 772-6436

AMG 820(c-fms antagonist)


Phase I(800) 772-6436



solid tumors


AMG 900(aurora kinase inhibitor)


(see also other) Phase I(800) 772-6436

AMP-224 AmplimmuneGaithersburg, MD

Phase I(301) 309-9800

anti-CD137 (BMS-663513)


Phase I(800) 332-2056

anti-IGF-1R mAb GenentechSouth San Francisco, CA

Phase I(800) 626-3553

anti-PD-L1(BMS-936559)


Phase I(800) 332-2056

Aplidin®

plitidepsinPharmaMarMadrid, Spain

(see also lymphoma, multiple myeloma)





(see also brain, leukemia) Phase I(862) 703-7170

ARQ 092(AKT inhibitor)


inoperable/unresectable late-stage solid tumors

Phase I(781) 994-0300(973) 944-2600

ARQ 621(Eg5 inhibitor)

ArQuleWoburn, MA

late-stage solid tumors(see also other)

Phase I(781) 994-0300

ARQ 736(BRAF inhibitor)

ArQuleWoburn, MA

late-stage solid tumors Phase I(781) 994-0300

ARQ 761(E2F1 stimulant)

ArQuleWoburn, MA

Phase I(781) 994-0300



late-stage solid tumors(see also skin)

Phase I(877) 633-2436




Phase I(877) 633-2436



solid tumors



Phase I(800) 695-4321(425) 527-4000

ASP3026 Astellas Pharma USDeerfield, IL

late-stage solid tumors(see also lymphoma)

Phase I(800) 695-4321



(see also leukemia, lymphoma, multiple myeloma)

Phase I(925) 560-0100



(see also leukemia, lymphoma, multiple myeloma)

Phase I(925) 560-0100

AT13387(Hsp90 inhibitor)


refractory solid tumors(see also stomach)

Phase I(925) 560-0100

ATI-1123(docetaxel liposomal)

Azaya TherapeuticsSan Antonio, TX

Phase I(210) 341-6600

AZD1480(JAK1/JAK2 inhibitor)


Phase I(800) 236-9933

AZD2014(TOR kinase inhibitor)


Phase I(800) 236-9933

AZD4547(FGFR tyrosine kinase inhibitor)


Phase II(800) 236-9933

AZD5363(AKT inhibitor)

Astex PharmaceuticalsDublin, CAAstraZenecaWilmington, DE

Phase I(800) 236-9933

AZD8330(ARRY-424704)(MEK inhibitor)

Array BioPharmaBoulder, COAstraZenecaWilmington, DE

Phase I(800) 236-9933

AZD8931(erbB kinase inhibitor)



BAY 10-00394(Pan-CDK inhibitor)



BAY 79-4620(antibody-drug conjugate)


Phase I(888) 842-2937



solid tumors


BAY 80-6946 Bayer HealthCare PharmaceuticalsWayne, NJ

Phase I(888) 842-2937

BAY 87-2243(HIF-1ἀ pathway inhibitor)


Phase I(888) 842-2937

BAY 94-9343(antibody drug conjugate)


Phase I(888) 842-2937

BBI503(stemness kinase inhibitor)

Boston BiomedicalNorwood, MA


BBI608(stemness inhibitor)

Boston BiomedicalNorwood, MA


belotecan OnKor PharmaceuticalsSeattle, WA

Phase II(206) 694-4424

BEZ235(kinase inhibitor)


Phase I/II(888) 669-6682

BGJ398(FGF-R kinase inhibitor)


Phase I(888) 669-6682

BGT226(MTOR/PI3K inhibitor)


Phase I/II(888) 669-6682

BHQ880(mAb)


(see also multiple myeloma) Phase I(888) 669-6682

BI-811283(aurora kinase B inhibitor)




Phase I(800) 243-0127

BI-836845(IgG1-lambda)


Phase I(800) 243-0127


Phase I(800) 243-0127



solid tumors


BI-853520(TYK2 inhibitor)


Phase I(800) 243-0127





BIND-014(docetaxel nanopharmaceutical)

BIND BiosciencesCambridge, MA

Phase I(617) 491-3400

BMN-673(PARP inhibitor)

BioMarin PharmaceuticalsNovato, CA

(see also other) Phase I/II(415) 506-6700

BQS481(Eg5 inhibitor)


Phase I(888) 669-6682

BYL719(PI3K-alpha inhibitor)



CA-18C3 XBiotechAustin, TX

(see also cancer-related, other) Phase I/II(512) 386-2900

CALAA 01(siRNA)

Calando PharmaceuticalsPasadena, CA

Phase I(626) 683-7200

carfilzomib Onyx PharmaceuticalsSouth San Francisco, CA


CBP-501(peptide mimetic)

CanBasShizouka, Japan

(see also lung) Phase Iwww.canbas.co.jp


CelgeneSummit, NJ


Phase I(908) 673-9000



Phase I(908) 673-9000

CDX-1127 Celldex TherapeuticsNeedham, MA


CDX-1401(cancer vaccine)


solid tumors expressing theNY-ESO-1 protein

Phase I/II(781) 433-0771

CEP-11981(VEGF-R/TIE2 kinase inhibitor)

CephalonFrazer, PA




solid tumors


CG201(cancer vaccine)

CG TherapeuticsSeattle, WA

Phase II(206) 336-5604

CRLX101 Cerulean PharmaCambridge, MA

late-stage solid tumors Phase I/II(617) 551-9600

crolibulin EpiCeptTarrytown, NY

Phase I/II(914) 606-3500

CUDC-101 CurisLexington, MA

Phase I(617) 503-6500

CVX 060 (PF-04856884)(Ang2 antagonist)

PfizerNew York, NY

(see also kidney) Phase I(860) 732-5156

CX-4945(CK2 inhibitor)

Cylene PharmaceuticalsSan Diego, CA


CYC116(aurora kinase/VEGFR2 inhibitor)


Phase I(908) 517-7330

CYT-6091(Aurimune)

CytImmune SciencesRockville, MD

Phase I(301) 825-3041

D-1MT NewLink GeneticsAmes, IA


D-3263(TRPM8 protein stimulant)

DendreonSeattle, WA

Phase I(877) 256-4545

dacomitinib(PF-00299804)

PfizerNew York, NY




(see also liver, lymphoma, multiple myeloma)

Phase I (646) 214-0700

DS-2248 Daiichi SankyoParsippany, NJ

Phase I(973) 944-2600

DS-7423 Daiichi SankyoParsippany, NJ

Phase I(973) 944-2600



solid tumors



metastatic solid tumors(see also brain, head/neck, liver, skin, stomach)

Phase I/II(888) 422-4743

EC17 EndocyteWest Lafayette, IN

Phase Iwww.endocyte.com



elsamitrucin Spectrum PharmaceuticalsHenderson, NV


EMD-1214063(c-Met kinase inhibitor)


Phase I(800) 283-8088

enavatuzumab Abbott LaboratoriesAbbott Park, IL

Phase I(847) 937-6100

EP-100 Esperance PharmaceuticalsBaton Rouge, LA

Phase I(225) 615-8944

ETBX-011cancer vaccine

EtubicsSeattle, WA

late-stage metastatic solid tumors Phase I(206) 838-5110

etirinotecan pegol (NKTR-102)


combination therapy(see also breast, colorectal, ovarian)

Phase I(855) 482-6587



solid tumors (pediatric)(see also breast, colorectal)--------------------------------------------------combination therapy

Phase I/II(973) 980-4500-------------------------------------------Phase I(973) 980-4500

EZN-2968(HIF1-alpha inhibitor)



ficlatuzumab(AV-299)

AVEO PharmaceuticalsCambridge, MA


fluciclatide F-18 GE HealthcareWaukesha, WINational Cancer InstituteBethesda, MD

solid tumors (diagnosis) Phase II(262) 513-4000

FP-1039/HGS1036 Five Prime TherapeuticsSouth San Francisco, CAHuman Genome SciencesRockville, MD

late-stage solid tumors Phase I(415) 365-5600(301) 309-8504



solid tumors


G-202 GenSperaSan Antonio, TX

Phase I(210) 479-8112

GC1008(fresolimumab)


Phase I(617) 252-7500

GDC-0032(PI3 kinase inhibitor)


metastatic solid tumors Phase I(800) 626-3553

GDC-0068(Akt inhibitor)


Phase I/II(800) 626-3553

GDC-0349(small molecule)



GDC-0425(ChK1 inhibitor)



GDC-0575 GenentechSouth San Francisco, CA





GDC-0917(IAP antagonist)





(see also skin cancer) Phase I(800) 626-3553



(see also breast, lymphoma) Phase I(800) 626-3553

Genz644282(toposisomerase-1 inhibitor)


Phase I(800) 981-2491

GGTI-2418 KiraxBonita Springs, FL

Phase I(239) 444-5400

GI-6301(brachyury peptide vaccine)


Phase I(303) 625-2700

GL-ONC1 GeneluxSan Diego, CA

Phase I(858) 483-0024

GO-203-2c Genus OncologyVernon Hills, IL




solid tumors


GSK461364(polio-like kinase inhibitor)



GSK690693(AKT kinase inhibitor)



GSK1070916A(selective aurora kinase B/C inhibitor)


Phase I(888) 825-5249

GSK2126458(PI3K/mTOR inhibitor)






GSK2256098(FAK inhibitor)


Phase I(888) 825-5249

GSK2636771(PI3K beta-selective inhibitor)


Phase I(888) 825-5249

HSP990(heat shock protein)


Phase I(888) 669-6682

IGF-1R antagonist(BMS-754807)


Phase II(800) 332-2056

IMF-001(cancer vaccine)

ImmunoFrontierTokyo, Japan

NY-ESO-1 antigen-expressing solid tumors

Phase Iwww.immunofrontier.com

IMGN388 ImmunoGenWaltham, MA

Phase I(781) 895-0600

INC280(c-Met inhibitor)


Phase I/II(888) 669-6682

INCB24360 IncyteWilmington, DE

(see also skin) Phase I/II(855) 446-2983

indium-111 (ABT-806) Abbott LaboratoriesAbbott Park, IL

solid tumors (diagnosis) Phase I(847) 937-6100




Phase I(858) 768-6500

INK1117(PI3Kα inhibitor)


Phase I(858) 768-6500



solid tumors


INNO-206 CytRxLos Angeles, CA

(see also pancreatic, sarcoma) Phase I/II(310) 826-5648

INNO-305(WT-1 vaccine)



JI-101(angiogenesis inhibitor)

Jubilant BiosysMalvern, PA

Phase I/II(610) 240-8690



late-stage solid tumors(see also lung, prostate)

Phase I(800) 817-5286

JX-929 Jennerex BiotherapeuticsSan Francisco, CA

Phase I(415) 281-8886

Karenitecin®

BNP1350BioNumerik PharmaceuticalsSan Antonio, TX

solid tumors (adults and pediatric)(see also lung, ovarian)

Phase I(210) 614-1701

KHK-2866 Kyowa Hakko Kirin PharmaPrinceton, NJ

advanced solid tumors(see also ovarian)

Phase I(609) 919-1100



(see also kidney, leukemia, multiple myeloma, prostate)

Phase I(888) 669-6682

LCI699(aldosterone synthase inhibitor)


Phase II(888) 669-6682

LCL161(IAP inhibitor)


Phase I(888) 669-6682

LDE225(erismodegib)


solid tumors (adults and pediatric)(see also leukemia, pancreatic, skin)

Phase I(888) 669-6682

LDK378(ALK inhibitor)


Phase I(888) 669-6682

LEE011(CDK4/6 inhibitor)



LEQ506(Smo antagonist)


Phase I(888) 669-6682

L-MDAM BioNumerik PharmaceuticalsSan Antonio, TX

Phase I(210) 614-1701

LOR 253(MTF-1 inhibitor)





solid tumors


LP-261 Locus PharmaceuticalsBlue Bell, PA

Phase I(215) 358-2000

lurbinectedin PharmaMarMadrid, Spain

(see also leukemia) Phase Iwww.pharmamar.com

ME-143(NADH oxidase inhibitor)

Marshall EdwardsSan Diego, CA

refractory solid tumors Phase I(858) 792-6300

MEDI-565(anti-CEA BiTE)


Phase I(800) 236-9933(301) 398-0000

MEDI-573(anti-IGF mAb)


Phase I(800) 236-9933(301) 398-0000

MEDI-0639(anti-delta-like 4 mAb)


Phase I(800) 236-9933(301) 398-0000

MEDI-3617(anti-ANG-2 mAb)


Phase I(800) 236-9933(301) 398-0000

MG-1102 Green CrossYongin, South KoreaMogam Biotechnology Research InstituteYongin, South Korea

second-line solid tumors Phase Iwww.eng.greencross.com

MGA271 (anti-B7-H3)

MacroGenicsRockville, MD

refractory metastatic solid tumors Phase I(301) 251-5172

MGAH22 (anti-HER2 mAb) MacroGenicsRockville, MD

Phase I(301) 251-5172

MINT1526A GenentechSouth San Francisco, CA

Phase I(800) 626-3553





solid tumors



metastatic late-stage solid tumors Phase I(800) 672-6372

MK-4827(PARP inhibitor)


Phase I(800) 672-6372

MK-5108/VX-689(aurora kinase A inhibitor)

MerckWhitehouse Station, NJVertex PharmaceuticalsCambridge, MA

Phase I(800) 672-6372(617) 444-6100



MLN0128 Millennium PharmaceuticalsCambridge, MA


MLN0518 (tandutinib)


Phase I(800) 390-5663


Phase I(800) 390-5663

MLN2480(raf kinase inhibitor)


Phase I(800) 390-5663

MLN4924(NEDD8 inhibitor)



MLN8237(alisertib)


(see also lymphoma) Phase II(800) 390-5663

MLN9708 (ixazomib)



Phase I(800) 390-5663

MM-151(EGFR antagonist)


Phase I(617) 441-1000

mocetinostat(MGCD0103, HDAC inhibitor)


(see also leukemia, lymphoma) Phase I/II(514) 337-3333

MPDL-3280A GenentechSouth San Francisco, CA

Phase I(800) 626-3553



solid tumors


MSC2015103B(MEK inhibitor)


Phase I(800) 283-8088

MTKi-328 BeiGeneBeijing, China

Phase Iwww.beigene.com

MTRN-2696 Spectrum PharmaceuticalsHenderson, NV

Phase I(702) 835-6300

NKP-1339 Niiki PharmaHoboken, NJ

Phase I(201) 710-5512

NKTR-105 (pegylated docetaxel)


Phase I(415) 482-5300

NMS-1116354(CDC7 protein kinase inhibitor)

Nerviano Medical ServicesNerviano, Italy

Phase Iwww.nervianoms.com

NMS-1286937(PIK-1 inhibitor)

Nerviano Medical ServicesNerviano, Italy

Phase Iwww.nervianoms.com

NPI-0052(marizomib)



Phase I(858) 587-4090

olaparib(PARP inhibitor)


Phase I(800) 236-9933

omapro™omacetaxine

CephalonFrazer, PA


OMP-18R5(Wnt pathway)

Bayer HealthCare PharmaceuticalsWayne, NJOncoMed PharmaceuticalsRedwood City, CA

Phase I(888) 842-2837(650) 995-8200

OMP-21M18(DLL4 inhibitor)

GlaxoSmithKlineRsch. Triangle Park, NCOncoMed PharmaceuticalsRedwood City, CA

Phase I(888) 825-5249(650) 995-8200

OMP-59R5(notch pathway)

GlaxoSmithKlineRsch. Triangle Park, NCOncoMed PharmaceuticalsRedwood City, CA

Phase I(888) 825-5249(650) 995-8200

omtriptolide PharmagenesisRedwood City, CAPierre Fabre PharmaceuticalsParsippany, NJ

Phase I(650) 842-7060www.pierre-fabre.com



solid tumors


ONT-10(cancer vaccine)

OncothyreonSeattle, WA

Phase I(206) 769-9219

ONX-0801 Onyx PharmaceuticalsSouth San Francisco, CA

Phase I(650) 266-0000

OPB-51602 Otsuka America PharmaceuticalRockville, MD

Phase I(800) 562-3974

oprozomib Onyx PharmaceuticalsSouth San Francisco, CA

Phase I(650) 266-0000


(see also leukemia, lung, lymphoma) Phase II(908) 673-9000

ortataxel Spectrum PharmaceuticalsHenderson, NV

taxane-refractory solid tumors Phase II(702) 835-6300

OSI-930(c-kit/VEGFR-2)


Phase I(631) 962-0600

p28 peptide CDG TherapeuticsChicago, IL

Phase Iwww.cdgti.com

paclitaxel liposomal Sun PharmaMumbai, India

Phase Iwww.sunpharma.com

palifosfamide(ZIO-201)


(see also lung, sarcoma) Phase I(646) 214-0700

pbi-shRNA™ StMN1 Lp(anti-stathim gene therapy)


Phase I(214) 442-8100


solid tumors (pediatric)(see also brain, colorectal, kidney, leukemia, lung, lymphoma, multiple myeloma, sarcoma, stomach)

Phase I(908) 626-5428

PF-00337210(VEGFR2 antagonist)

PfizerNew York, NY


PF-03446962(ALK-1 mAb)

PfizerNew York, NY

Phase I(860) 732-5156



solid tumors


PF-04605412(anti-α5β1 integrin mAb)

PfizerNew York, NY

Phase I(860) 732-5156

PF-04691502(PI3K/mTOR inhibitor)

PfizerNew York, NY


PF-05212384(mTOR/PI3K inhibitor)

PfizerNew York, NY


PG11047 Progen PharmaceuticalsQueensland, Australia

(see also lymphoma) Phase Iwww.progen-pharma.com



metastatic solid tumors(see also brain, leukemia, lymphoma)

Phase I(510) 647-4000



PNT2258(bcl-2 oncogene inhibitor)

ProNAi TherapeuticsAnn Arbor, MI

Phase I(269) 815-8098

PRI-724(CBP/catenin inhibitor)

PRISM BioLabYokohama, Japan

Phase Iwww.prismbiolab.com

PRLX93936 Prolexys PharmaceuticalsSalt Lake City, UT

Phase I


(see also breast, other) Phase II(908) 222-7000

purine nucleoside phosphorylasegene therapy

PNP TherapeuticsBirmingham, AL

Phase Iwww.pnptherapeutics.com

PWT33597(PI3K alpha/mTOR kinase)

Pathway TherapeuticsSan Francisco, CA

Phase Iwww.pathwaytx.com

QBI-139 Quintessence BiosciencesMadison, WI

Phase I(608) 441-2950

RAF265(raf kinase inhibitor)


(see also skin) Phase I/II(888) 669-6682



solid tumors



(see also colorectal, kidney, lung, stomach)

Phase I(888) 842-2837

Reolysin®


solid tumors (pediatric)(see also brain, colorectal, head/neck, lung, ovarian, pancreatic, sarcoma, skin)

Phase I(403) 670-7377

RG7112(MDM2 antagonist)

RocheNutley, NJ


RG7116(ErbB-3 receptor antagonist)

Roche Nutley, NJ

Phase I(973) 235-5000

RG7155(anti-CSF-1R mAb)

RocheNutley, NJ

Phase I(973) 235-5000

RG7167(CIF/MEK inhibitor)

RocheNutley, NJ

Phase I(973) 235-5000

RG7304(MAP/raf inhibitor)

RocheNutley, NJ

Phase I(973) 235-5000

RG7321(PI3Kα inhibitor)

GenentechSouth San Francisco, CARocheNutley, NJ

Phase II(800) 626-3553(973) 235-5000

RG7347(NRP1 antagonist)

GenentechSouth San Francisco, CARocheNutley, NJ

Phase I(800) 626-3553(973) 235-5000

RG7356(CD44 antigen inhibitor)

RocheNutley, NJ

Phase I(973) 235-5000

RG7388(MDM2 inhibitor)

RocheNutley, NJ


RG7444(HFGR-1877S)



RG7446(mAb)


Phase I(800) 626-3553

RG7594(mAb)


advanced solid tumors Phase I(800) 626-3553



solid tumors





solid tumors (combination therapy)(see also colorectal, sarcoma)--------------------------------------------------solid tumors (pediatric)

Phase II(800) 672-6372-------------------------------------------Phase I(800) 672-6372

RRx-001 RadioRxMountain View, CA

Phase I(650) 681-9885

sapacitabine (CYC682)


(see also leukemia, lung) Phase I(908) 517-7330

SAR125844(Met kinase inhibitor)


Phase I(800) 981-2491

SAR153192(anti-DLL4 mAb)


Phase I(800) 981-2491

SAR245408/MSC1936369Bcombination therapy(PI3K inhibitor/MEK inhibitor)

Merck SeronoGeneva, SwitzerlandSanofi USBridgewater, NJ

Phase I(800) 981-2491

SAR245409/MSC1936369Bcombination therapy(PI3K-mTOR inhibitor/MEK inhibitor)

Merck SeronoGeneva, SwitzerlandSanofi USBridgewater, NJ

Phase I(800) 981-2491

SAR256212 (MM-121) companion diagnostic


solid tumors (diagnosis) Phase II(800) 981-2491

SAR307746 (REGN910)(anti-Ang2 mAb)


Phase I(914) 347-7000(800) 981-2491

SAR566658(maytansin-loaded anti-DS6)


DS6-positive solid tumors Phase I(800) 981-2491

SB989 (pracinostat)

S*BIOOakland, CA

late-stage solid tumors(see also leukemia, other)

Phase I(650) 730-2860



solid tumors


SCH-900353 MerckWhitehouse Station, NJ

Phase I(800) 672-6372

seliciclib (CYC202)


(see also head/neck) Phase I(908) 517-7330

selumetinib (AZD6244/ARRY-142886)(MEK inhibitor)


Phase II(800) 236-9933

selumetinib (AZD6244/ARRY-142886)/ MK2206 combination (MEK/AKT inhibitor)

AstraZenecaWilmington, DEMerckWhitehouse Station, NJ

Phase I(800) 236-9933(800) 672-6372

SF1126 Semafore PharmaceuticalsIndianapolis, IN


Phase I(317) 876-3075

simotaxel IV TaxologFairfield, NJ

Phase I(866) 829-6564

solid tumor immunotherapy(mAb)


Phase I(800) 626-3553

sonepcizumab LpathSan Diego, CA

Phase I(858) 678-0800

SPI-1620(endothelin B receptor agonist)

Spectrum PharmaceuticalsHenderson, NV

Phase I(702) 835-6300

TAG vaccine GradalisCarrollton, TX

Phase I(214) 442-8100

TAK-385(gonadotrophin hormone-releasing hormone receptor antagonist)


Phase I(800) 390-5663

TAK-441(hedgehog signaling pathway inhibitor)


Phase I(800) 390-5663

TAK-701(HGF inhibitor)


Phase I(800) 390-5663

TAK-733(MEK inhibitor)


Phase I(800) 390-5663



solid tumors


TAK-960(Plk1 inhibitor)


Phase I(800) 390-5663

teglarinad CephalonFrazer, PA



solid tumors (IV-infusion)(see also brain, cervical, head/neck, other)

Phase I(713) 541-2000

TKM-PLK1(RNAi)

Tekmira PharmaceuticalsBurnaby, Canada


TL-32711(birinapant)

TetraLogic PharmaceuticalsMalvern, PA


TLC-388 TLC BiopharmaceuticalsSouth San Francisco, CA

Phase I(650) 872-8816

TRC093(IgG1 mAb)



TRC102(DNA repair inhibitor)


Phase I(858) 550-0780

tremelimumab(anti-CTLA4 mAb)


Phase II(800) 236-9933(301) 398-0000

TST-10088 CangeneWinnipeg, Canada

Phase I(204) 275-4200

U3-1565(anti-HB-EGF antibody)

AmgenThousand Oaks, CA Daiichi Sankyo USParsippany, NJ

Phase I(800) 772-6436(973) 944-2600

UNBS-5162 Drais PharmaceuticalsBridgewater, NJ


V934/V935 MerckWhitehouse Station, NJ


V935(telomerase inhibitor vaccine)

GeronMenlo Park, CAMerckWhitehouse Station, NJ

Phase I(650) 473-7700(800) 672-6372



solid tumors


VGX-100(VEGF-C mAb)

Circadian TechnologiesVictoria, Australia

Phase Iwww.circadian.com.au

VTX-2337 VentiRx PharmaceuticalsSeattle, WA


VX15 VaccinexRochester, NY

Phase I(585) 271-2700

WX-UK1 WilexMunich, Germany

Phase Iwww.wilex.de

X-82(dual VEGFR/PDGFR inhibitor)

TyrogenexWest Palm Beach, FL

advanced solid tumors Phase I(561) 835-9356

Xalkori®crizotinib

PfizerNew York, NY


XMT-1001 Mersana TherapeuticsCambridge, MA

Phase I(617) 498-0020

XMT-1107 Mersana TherapeuticsCambridge, MA

Phase I(617) 498-0020

stomaCH CanCer




late-stage esophageal cancer (combination therapy)(see also brain, leukemia, lung, lymphoma, prostate)

Phase I/II(610) 408-0301

AT13387(Hsp90 inhibitor)


late-stage gastrointestinal stromal tumors (GIST) (second-line therapy) (see also solid tumors)

Phase II(925) 560-0100



second-line GIST(see also breast, colorectal, lung, multiple myeloma)

Phase II(888) 669-6682


GIST(see also breast)




stomaCH CanCer


crenolanib (CP-868-596)

AROG PharmaceuticalsDallas, TX

GIST(see also brain)

Phase II(214) 594-0002


gastric cancer (combination therapy)(see also brain, head/neck, liver, skin, solid tumors)

Phase I/II(888) 422-4743

eRBItUX® cetuximab

Bristol-Myers SquibbPrinceton, NJEli LillyIndianapolis, IN

gastric cancer(see also colorectal)

in clinical trials(800) 332-2056(800) 545-5979

ganetespib (Hsp90i)


esophageal cancer, gastric cancer, GIST(see also breast, colorectal, leukemia, liver, lung, multiple myeloma, pancreatic, prostate, skin)

Phase II(781) 274-8200

masitinib(orphan Drug)

AB Science USAShort Hills, NJ

GIST(see also pancreatic)

Phase III(973) 218-2437



esophageal cancer(see also brain, lung, ovarian, other)

Phase II(800) 215-2355


GIST(see also brain, colorectal, kidney, leukemia, lung, lymphoma, multiple myeloma, sarcoma, solid tumors)

Phase II(908) 626-5428

polyclonal antibody stimulator(orphan Drug)

Cancer AdvancesDurham, NC

gastric cancer(see also colorectal, pancreatic)

Phase III(919) 361-2162



gastric cancer(see also breast, colorectal)

Phase III(800) 545-5979

regorafenib(orphan Drug)


GIST (Fast Track)(see also colorectal, kidney, lung, solid tumors)

Phase III(888) 842-2837

S-1 Taiho Pharma U.S.A.Princeton, NJ

gastric cancer Phase III(609) 750-5300

tasigna®nilotinib(orphan Drug)


GIST (see also leukemia, skin)

Phase III(888) 669-6682



stomaCH CanCer


telatinib(orphan Drug)

ACT BiotechSan Francisco, CA

gastric cancer (combination therapy)(see also colorectal)

Phase II(415) 230-3900

tesetaxel(orphan Drug)

GentaBerkeley Heights, NJ

gastric cancer(see also bladder, breast, prostate, skin)

Phase II(908) 286-9800

tNFerade™golnerminogene pradenovac


esophageal cancer(see also head/neck, prostate, skin)

Phase II(877) 943-6832

trebananib (AMG386)


esophageal cancer, gastric cancer(see also breast, colorectal, kidney, liver, ovarian, other)

Phase II(800) 772-6436

tykerb®


gastric cancer(see also breast, head/neck)

Phase III(888) 825-5249

uridine triacetate (PN401)

Wellstat TherapeuticsGaithersburg, MD

gastric cancer(see also pancreatic)

Phase II(240) 631-2500

Xeloda®


esophageal cancer (see also brain, colorectal, liver)

Phase II(800) 626-3553

CanCer/CHemotHerapy-related Conditions


AG103 ActoGenixZwijnaarde, Belgium

oral mucositis associated with cancertreatment

Phase Iwww.actogenix.com

AP1903 Bellicum PharmaceuticalsHouston, TX

graft-versus-host disease(see also prostate)

Phase I(713) 341-6472

ARX-02 (sufentanil sublingual)

AcelRx PharmaceuticalsRedwood City, CA

breakthrough cancer pain Phase II(650) 216-3500


cancer-related cachexia(see also other, solid tumors)

Phase I/II(512) 386-2900





CD1400(oltipraz)

Canopus BioPharmaStudio City, CA

chemotherapy- and radiation-inducedmucositis

Phase IIwww.canopusbiopharma.com

CLT-008 Cellerant TherapeuticsSan Carlos, CA

chemotherapy-related neutropenia(see also other)

Phase I/II(650) 232-2122

dronabinol oral solution INSYS TherapeuticsPhoenix, AZ

chemotherapy-induced nausea and vomiting

Phase III(602) 910-2617


oral mucositis Phase III(888) 422-4743

emend®

aprepitantMerckWhitehouse Station, NJ

chemotherapy-induced nausea and vomiting (pediatric)

Phase III(800) 672-6372

emend® IVaprepitant


chemotherapy-induced nausea and vomiting (pediatric)

Phase I(800) 672-6372

fentanyl inhalation Akela PharmaAustin, TX

cancer pain Phase II/III(512 834-0449

ferroportin mAb Eli LillyIndianapolis, IN

anemia associated with cancer Phase I(800) 545-5979

fulranumab Johnson & Johnson PharmaceuticalResearch & DevelopmentRaritan, NJ

cancer pain (adjunctive treatment) Phase II(800) 817-5286

hepcidin mAb Eli LillyIndianapolis, IN

anemia associated with cancer Phase I(800) 545-5979

LG631 LentigenGaithersburg, MD

chemoprotection in patients undergoing treatment for glioblastoma

Phase I(301) 527-4200

mesenchymal stem cell therapy(orphan Drug)

MesoblastNew York, NY

for bone marrow regeneration in patients undergoing bone marrow transplantation

Phase III(212) 880-2060

morphine intranasal Marina BiotechBothell, WA

cancer pain Phase II(425) 908-3600

MultiStem®

stem cell therapy(orphan Drug)

Athersys Cleveland, OH

graft-versus-host disease in patients undergoing bone marrow transplant

Phase I(216) 431-9900





nabiximols Otsuka America PharmaceuticalRockville, MD

cancer pain (adjunctive treatment) Phase III(800) 562-3974

netupitant/palonosetron Helsinn TherapeuticsBridgewater, NJ


Phase III(908) 231-1435

NP-2 gene therapy(intradermal)

Diamyd MedicalPittsburgh, PA

cancer pain Phase II(412) 770-1310

Nplate®

romiplostimAmgenThousand Oaks, CA

chemotherapy-associated thrombocytopenia

Phase II(800) 772-6436


chemotherapy-induced gastrointestinal disorders(see also colorectal, liver, pancreatic)

Phase I/II(203) 777-3462

prochymal®remestemcel-L(orphan Drug)

Osiris TherapeuticsColumbia, MD

graft-versus-host disease Phase III(443) 545-1800

proDermaCel™norepinephrine topical

ProCertus BioPharmMadison, WI

prevention of oral mucositis, prevention of radiation-induced skin damage

Phase I/II(608) 273-8862

promacta®

eltrombopagGlaxoSmithKlineRsch. Triangle Park, NC

chemotherapy-induced thrombocytopenia

Phase II(888) 669-6682

RGI-2001 REGiMMUNESanta Clara, CA

graft-versus-host disease Phase I/IIwww.regimmune.com

rolapitant TESAROWaltham, MA


Phase III(339) 970-0900

SGX201 SoligenixPrinceton, NJ

acute radiation enteritis in patients with cancer

Phase I/II(609) 538-8200

sotatercept (ACE-011)

CelgeneSummit, NJ

chemotherapy-induced anemia(see also other)

Phase II/III(908) 673-9000

tanezumab PfizerNew York, NY

cancer pain (adjunctive treatment) Phase II (860) 732-5156

tavocept®dimesna

BioNumerik PharmaceuticalsSan Antonio, TX

chemoprotection(see also lung)

Phase III(210) 614-1701





T-cell replacement therapy Bellicum PharmaceuticalsHouston, TX

graft-versus-host disease in patients with late-stage cancer undergoing bone marrow transplantation

Phase I(713) 341-6472

TH-9402(orphan Drug)

Kiadis PharmaAmsterdam, Netherlands

graft-versus-host disease Phase I/IIwww.kiadis.com

TXA127 Tarix PharmaceuticalsCambridge, MA

chemotherapy-induced thrombocytopenia

Phase IIwww.tarixpharma.com

Velcade®


steroid-refractory graft-versus-host disease (see also leukemia, lymphoma, other)

Phase II(800) 390-5663

XEN-2174 XenomeQueensland, Australia

cancer pain Phase IIwww.xenome.com

Xgeva™denosumab


prevention of cancer-related bone damage or malignant hypercalcemia(see also multiple myeloma, other)

Phase III(800) 772-6436

otHer CanCers



peritoneal cancer(see also brain, sarcoma)

Phase I(301) 608-9292

Å6 Angstrom PharmaceuticalsSolana Beach, CA

gynecologic cancer(see also ovarian)

Phase I(858) 314-2356

ABT-348(aurora kinase inhibitor)


hematological malignancies(see also solid tumors)

Phase I(847) 937-6100



fallopian tube cancer(see also brain, breast, colorectal, lung, lymphoma, ovarian, prostate, skin)

Phase II(847) 937-6100


late-stage endometrial cancer(see also bladder, ovarian, prostate)

Phase II(908) 626-5428

AlloStim™ Immunovative TherapiesShoham, Israel


Phase I/IIwww.immunovative.co.il



otHer CanCers


Alpharadin®

radium-223 chlorideBayer HealthCare PharmaceuticalsWayne, NJ

bone metastases from castration-resistant prostate cancer(see also solid tumors)



urogenital cancer(see also skin)

Phase I/II(954) 443-8600

AMG 319(PI3K-delta inhibitor)


hematological malignancies Phase I(800) 772-6436

AMG 900(aurora kinase inhibitor)



Phase I(800) 772-6436

anti-CD70 ADC(BMS-936561)



anti-CXCR4 (BMS-936564)



ARQ 621(Eg5 inhibitor)

ArQuleWoburn, MA


Phase I(781) 994-0300

Avastin®


high-risk carcinoid tumor(see also brain, breast, colorectal, lung, ovarian)

Phase III(800) 626-3553

BAY 10-02670 Bayer HealthCare PharmaceuticalsWayne, NJ

uterine leiomyoma Phase I(888) 842-2937


peritoneal cancer, thymoma(see also colorectal, leukemia, liver, lung, lymphoma, ovarian)--------------------------------------------------first-line thymoma

--------------------------------------------------recurrent hematological malignancies(combination therapy)

Phase II(702) 835-6300

-------------------------------------------Phase I/II(702) 835-6300-------------------------------------------Phase I(702) 835-6300



second-line endometrial cancer, second-line urogenital cancer(see also brain, breast, lung)

Phase II(888) 669-6682

BMN-673(PARP inhibitor)

BioMarin PharmaceuticalsNovato, CA




otHer CanCers


BP-100-1-01 Bio-PathOgden, Utah



hematological malignancies(see also cancer-related, solid tumors)

Phase I(512) 386-2900

cabozantinib(XL184)(orphan Drug)


medullary thyroid cancer(see also breast, kidney, lung, ovarian, prostate)

Phase III(650) 837-7000

catumaxomab Fresenius Biotech North AmericaWaltham, MA

malignant ascites(see also ovarian)

Phase IIwww.fresenius-biotech.com

CDX-1127 Celldex TherapeuticsNeedham, MA


Phase I(781) 433-0771

clodronic acid Bayer HealthCare PharmaceuticalsWayne, NJ

bone metastases Phase III(888) 842-2937

CLT-008 Cellerant TherapeuticsSan Carlos, CA

hematological malignancies(see also cancer-related)

Phase I(650) 232-2122

CPI-613(orphan Drug)

Cornerstone PharmaceuticalsCranbury, NJ

hematological malignancies(see also pancreatic)

Phase I(609) 409-7050



neuroendocrine tumors(see also breast, lung, pancreatic)

Phase II(800) 672-6372

DMUC-5754A GenentechSouth San Francisco, CA

first-line fallopian tube cancer,second-line peritoneal cancer(see also ovarian)

Phase I(800) 626-3553

DN24-02(lapuleucel-T) dendritic cell vaccine

Dendreon Seattle, WA

high-risk, HER2-positive urogenitalcancer (adjuvant therapy)

Phase II(877) 256-4545

E7080(lenvatinib)


thyroid cancer(see also brain, skin)--------------------------------------------------endometrial cancer


E7850(irofulven)


thyroid cancer(see also ovarian, prostate)

Phase II(888) 422-4743


thyroid cancer(see also colorectal, lung)

Phase I/II(973) 944-2600



otHer CanCers


EGEN-001 EGENHuntsville, AL

fallopian tube cancer, peritoneal cancer(see also colorectal, ovarian)

Phase II(256) 512-0077

elagolix Abbott LaboratoriesAbbott Park, ILNeurocrine BiosciencesSan Diego, CA

uterine leiomyoma Phase II(847) 938-6100(858) 617-7600

ENMD-2076 EntreMedRockville, MD

late-stage cancer(see also multiple myeloma, ovarian)

Phase I(240) 864-2600

Femara®

letrozoleNovartis PharmaceuticalsEast Hanover, NJ

recurrent, metastatic endometrial cancer (combination therapy)

Phase II(888) 669-6682



endometrial cancer(see also breast, ovarian)

Phase I/II(855) 855-4253

fostamatinib(SYK inhibitor)

AstraZenecaWilmington, DERigel PharmaceuticalsSouth San Francisco, CA

hematological malignancies Phase II(800) 236-9933(650) 624-1100

Gleevec®


fibroma(see also lung, prostate, skin)

Phase II(888) 669-6682

Inlyta®

axitinibPfizerNew York, NY

thyroid cancer(see also kidney, liver)

Phase II(860) 732-5156

IPI-145 Infinity PharmaceuticalsCambridge, MA


Istodax®


hematological malignancies(see also kidney, pancreatic, prostate)

Phase I(908) 673-9000

IXeMpRA® ixabepilone


endometrial cancer in clinical trials(800) 332-2056

Jakafi™ruxolitinib

Incyte Wilmington, DE

hematological malignancies(see also pancreatic)

Phase II(855) 446-2983

KB004 KaloBios PharmaceuticalsSouth San Francisco, CA


Marqibo®

vincristine liposomalTalon TherapeuticsSan Mateo, CA

pediatric cancers(see also leukemia, lymphoma, skin)

Phase I/II(650) 588-6404



otHer CanCers


MEDI-551(anti-CD19 mAb)


hematological malignancies Phase I(800) 236-9933(301) 398-0000

MER-101 (zoledronic acid oral)

Merrion PharmaceuticalsWilmington, NC

bone metastases Phase IIwww/merrionpharma.com

Mirena®

levonorgestrel-releasingintrauterine system

Bayer HealthCare PharmaceuticalsWayne, PA

endometrial cancer, endometrial hyperplasia

Phase II(888) 842-2937

MK-0752(notch signaling pathwayinhibitor)


central nervous system (CNS) cancer in patients ages 3-21(see also breast)

Phase I(800) 672-6372

MK-2206(c-akt inhibitor)

Merck Whitehouse Station, NJ

inoperable/unresectable neuroendocrine tumors(see also breast)

Phase II(800) 672-6372



Phase I(800) 390-5663

MLN4924(NEDD8 inhibitor)


hematological malignancies(see aslo solid tumors)

Phase I(800) 390-5663


thyroid cancer(see also breast, colorectal, lung)

Phase II(800) 772-6436

moxetumomab pasudotox(CAT-8015)



MSC1936369B EMD SeronoRockland, MA

hematological malignancies Phase I/II(800) 283-8088

Nexavar®


thyroid cancer(see also breast, colorectal, head/neck, kidney, leukemia, liver, lung, multiple myeloma, ovarian)--------------------------------------------------neuroendocrine tumors

Phase III(888) 842-2937

-------------------------------------------Phase I(888) 842-2937

NiCord®

umbilical cord blood stem cell therapy

Gamida CellJerusalem, Israel

hematological malignancies Phase I/IIwww.gamida-cell.com



otHer CanCers


NTX-010 NeotropixMalvern, PA

neuroendocrine tumors(see also lung)

Phase Iwww.neotropix.com



fallopian tube cancer, peritoneal cancer(see also brain, lung, ovarian, stomach)

Phase III(800) 215-2355

OPR-003 EUSA PharmaLanghorne, PAVaccinexRochester, NY




adrenocortical carcinoma(see also lung, ovarian)

Phase III(631) 962-0600



pediatric cancer(see also liver, prostate, skin)

Phase I(858) 452-6688

PF-04691502(PI3K/mTOR inhibitor)

PfizerNew York, NY

endometrial cancer(see also solid tumors)

Phase II(860) 732-5156

PF-05212384(mTOR/PI3K inhibitor)

PfizerNew York, NY

endometrial cancer(see also solid tumors)

Phase II(860) 732-5156

PHA848125 Nerviano Medical ServicesNerviano, Italy

thymoma Phase IIwww.nervianoms.com


fallopian tube cancer (combination therapy)(see also ovarian, prostate)

Phase I/II(858) 792-6300


endometrial cancer(see also cervical, sarcoma)

Phase IIwww.pharmamar.com


central nervous system (CNS) cancer in children(see also breast, solid tumors)

Phase II(908) 222-7000

RG7112(MDM2 antagonist)

RocheNutley, NJ


Phase I(973) 235-5000

RG7388(MDM2 inhibitor)

RocheNutley, NJ


Phase I(973) 235-5000

RG7593(mAb)

RocheNutley, NJ




otHer CanCers






endometrial cancer(see also breast, kidney, lung, prostate, sarcoma)

Phase II(800) 672-6372

rintatolimod Hemispherx BiopharmaPhiladelphia, PA

cancer vaccine adjuvant Phase I/II(215) 988-0080



bone metastases(see also breast, multiple myeloma, prostate, sarcoma)

Phase III(800) 833-3533

SAR3419(maytansin-loaded anti-CD19 mAb)

Sanofi USBridgewater, NJImmunoGenNeedham, MA

B-cell malignancies Phase II(800) 981-2491(781) 895-0600

SAR245408 (XL147)(oral PI3K inhibitor)


endometrial cancer(see also breast)

Phase II(800) 981-2491(650) 837-7000

SAR650984(anti-CD38 naked mAb)



SB989 (pracinostat)

S*BIOOakland, CA

hematological malignancies(see also leukemia, solid tumors)

Phase I(650) 730-2860


giant lymph node hyperplasia(see also multiple myeloma, prostate)

Phase II(800) 526-7736

SOM230 (pasireotide)


carcinoid tumors

--------------------------------------------------meningioma, neuroendocrine tumors


sotatercept (ACE-011)

CelgeneSummit, NJ

cancer metastases(see also cancer-related)

Phase II(908) 673-9000

SpRYCeL®


pediatric cancer(see also brain, breast, pancreatic, prostate)




otHer CanCers


Stemex®

carlecortemcel-L(orphan Drug)

Gamida CellJerusalem, IsraelTeva North AmericaNorth Wales, PA

hematological malignancies(Fast Track)

Phase III(888) 838-2872

TAK-901(aurora kinase B inhibitor)



tarceva®


gynecological cancer (see also brain, breast, head/neck, leukemia, liver, lung)

Phase II(800) 626-3553(631) 962-0600

telapristone Repros TherapeuticsThe Woodlands, TX

uterine leiomyoma Phase I/II(281) 719-3400


hematological malignancies (intravenous)(see also brain, cervical, head/neck, solid tumors)

Phase I(713) 541-2000

TG02 S*BIOOakland, CATragara PharmaceuticalsSan Diego, CA




germ cell and embryonal neoplasms(see also colorectal, kidney, liver, lung, pancreatic, sarcoma)

Phase II(781) 994-0300(973) 944-2600

TKI258(dovitinib)


second-line endometrial cancer, urothelial carcinoma(see also breast, kidney, multiple myeloma, prostate, skin)

Phase II(888) 669-6682



fallopian tube cancer, peritoneal cancer(see also breast, ovarian, prostate)

Phase II(858) 550-0780

trebananib (AMG386) AmgenThousand Oaks, CA

fallopian tube cancer, peritoneal cancer(see also breast, colorectal, kidney, liver, stomach)

Phase III(800) 772-6436



otHer CanCers


ulipristal Watson PharmaceuticalsParsippany, NJ

uterine leiomyoma Phase III(800) 900-1644

VB-111 VBL TherapeuticsOr Yehuda, Israel

thyroid cancer(see also brain)

Phase I/IIwww.vblrx.com

Velcade®


adenocarcinoma (combination therapy)(see also leukemia, lymphoma, cancer-related)

Phase II(800) 390-5663

volasertib Boehringer Ingelheim PharmaceuticalsRidgefield, CT

urogenital cancer Phase II(800) 243-0127



fallopian tube cancer, peritoneal cancer(see also kidney, ovarian)

Phase III(888) 825-5249

Xgeva™denosumab


prevention of bone metastases in men with castrate-resistant prostate cancer(see also cancer-related, multiple myeloma)--------------------------------------------------prevention of bone metastases in women with early-stage breast cancer--------------------------------------------------giant cell tumor of bone


-------------------------------------------Phase III(800) 772-6436

-------------------------------------------Phase II(800) 772-6436



inoperable/unresectable thyroid cancer(see also brain, colorectal)

Phase II(800) 626-3553(510) 647-4000

Zolinza®


gynecological cancer, peritoneal cancer(see also breast, leukemia, lung, lymphoma, multiple myeloma)

Phase I/II(800) 672-6273



unspeCified CanCer


ABC294640 Apogee BiotechnologyHummelstown, PA

late-stage disease Phase I(843) 792-3420

ABI-011(nab®-5404)

CelgeneSummit, NJ

Phase I(908) 673-9000

AFX-9901 Afecta PharmaceuticalsIrvine, CA


AGS-6MF AgensysSanta Monica, CAAstellas Pharma USDeerfield, IL

Phase I(800) 695-4321

AGS-16M8F AgensysSanta Monica, CAAstellas Pharma USDeerfield, IL

Phase I(800) 695-4321


Phase I/II(954) 443-8600

anti-KIR(BMS-986015)


Phase I(800) 332-2056

anti-LAG3(BMS-986016)


Phase I(800) 332-2056

ANX-514(docetaxel for injectable emulsion)

ADVENTRX PharmaceuticalsSan Diego, CA

Phase I(858) 552-0866


Array BioPharmaBoulder, CONovartis PharmaceuticalsEast Hanover, NJ

Phase I(877) 633-2436(888) 669-6682

ARRY-382(c-fms antagonist)

Array BioPharmaBoulder, COCelgeneSummit, NJ

metastatic cancer Phase I(877) 633-2436(908) 673-9000


CelgeneSummit, NJ

(see also leukemia, lymphoma) Phase I(908) 673-9000

B7-2/GM-CSFcancer gene therapy vaccine

NuVax TherapeuticsTustin, CA

Phase I(714) 505-4461

BAY 94-9392(PET imaging)


cancer (diagnosis) Phase I(888) 842-2937



unspeCified CanCer


cancer vaccine Immunitor USAVancouver, Canada

Phase I/IIwww.immunitor.com

cancer vaccine(fibrocyte vaccine)

Cytokine PharmaSciencesKing of Prussia, PA

Phase I(610) 687-1776

carboxyamidotriazole orotate(CTO)

Tactical TherapeuticsNew York, NY

Phase I(212) 651-9653

CBLB502 Cleveland BioLabsBuffalo, NY

Phase I(716) 849-6810

CDK 4/6 inhibitor(LY2835219)


Phase II(800) 545-5979

CDX-301(Fms-like tyrosine kinase 3 ligand)


Phase I(781) 433-0771

cell therapy Cell MedicaLondon, United KingdomCenter for Cell and Gene TherapyHouston, TX

Phase IIwww.cellmedica.co.uk

CEN-109 Centella TherapeuticsPalo Alto, CA

cancer (diagnosis) Phase IIwww.centellatx.com

Chk1 inhibitor Eli LillyIndianapolis, IN

Phase I(800) 545-5979

c-Met inhibitor Eli LillyIndianapolis, IN

Phase I(800) 545-5979

c-Met mAb(LY2875358)


Phase II(800) 545-5979

CSF-1R mAb(IMC-CS4)


Phase I(800) 545-5979

curmucin Signpath PharmaQuakertown, PA

Phase I(267) 772-0107

CXCR4 peptide inhibitor(LY2510924)


Phase II(800) 545-5979



unspeCified CanCer


cytotropic heterogeneous molecular lipids(CHML)

Glory PharmaceuticalsVienna, VA

Phase I(703) 204-1703

DM-CHOC-PEN Dekk-TecNew Orleans, LA

Phase I(504) 583-6135



EGFR/IGFR tandem adnectin(BMS-964210)


Phase I(800) 332-2056

eIF-4E ASO(LY2275796)


Phase II(800) 545-5979

fenretinide intravenous CerRxLubbock, TX

Phase Iwww.cerrx.com

FGF receptor inhibitor Eli LillyIndianapolis, IN

Phase I(800) 545-5979

fluorapacin ACEA BiosciencesSan Diego, CA

Phase I(866) 308-2232

gemcitabine prodrug Eli LillyIndianapolis, IN

Phase I(800) 545-5979



Phase I(303) 625-2700

GSK3 inhibitor(LY2090314)


Phase II(800) 545-5979

HBI-8000 HUYA Bioscience InternationalSan Diego, CAQuintilesRsch. Triangle Park, NC

Phase Iwww.huyabio.com

hedgehog antagonist(LY2940680)


Phase II(800) 545-5979

hTERT plasmid DNA cancer vaccine

MerckWhitehouse Station, NJVicalSan Diego, CA

Phase I(800) 672-6372



unspeCified CanCer


IL-21 (BMS-982470)


Phase I(800) 332-2056

In-111-DACimaging agent

Mayo ClinicRochester, MNNaviscanSan Diego, CA

cancer (diagnosis) Phase Iwww.mayoclinic.org

ISIS-STAT3Rx Isis PharmaceuticalsCarlsbad, CA

Phase I(800) 679-4747

JAK2 inhibitor Eli LillyIndianapolis, IN

Phase I(800) 545-5979

masoprocol TriAct TherapeuticsSan Francisco, CA

Phase II(415) 602-7497

MK-8033(c-Met/RON protein inhibitor)


Phase I(800) 672-6372

new molecular entity Eli LillyIndianapolis, IN

Phase I(800) 545-5979

notch inhibitor Eli LillyIndianapolis, IN

Phase I(800) 545-5979

notch inhibitor (BMS-906024)


Phase I(800) 332-2056

OPB-31121 Otsuka America PharmaceuticalRockville, MD

Phase I(800) 562-3974

p38 MAP inhibitor (1) Eli LillyIndianapolis, IN

Phase I(800) 545-5979

p38 MAP inhibitor (2) Eli LillyIndianapolis, IN

Phase I(800) 545-5979

p70/AKT inhibitor Eli LillyIndianapolis, IN

Phase I(800) 545-5979

PB-357 Puma BiotechnologyLos Angeles, CA

Phase I(424) 248-6500



unspeCified CanCer


PBI-05204 Phoenix BiotechnologySan Antonio, TX

Phase I(210) 828-4373

PD-0325901 PfizerNew York, NY

Phase I(860) 732-5156

PD-0332991 PfizerNew York, NY

Phase II(860) 732-5156

PF-03084014(gamma-secretase inhibitor)

PfizerNew York, NY

Phase I(860) 732-5156

PF-04449913(sonic hedgehog pathway inhibitor)

PfizerNew York, NY

Phase I(860) 732-5156

PF-05082566(CD137 antigen agonist mAb)

PfizerNew York, NY

Phase I(860) 732-5156

proleukin®

aldesleukin(subcutaneous)

Prometheus LaboratoriesSan Diego, CA

Phase II(888) 892-8391

PRT6207(Syk-specific inhibitor)

Biogen IdecCambridge, MAPortola PharmaceuticalsSouth San Francisco, CA

Phase I(781) 464-2000(650) 246-7000

RON mAb(IMC-RON8)


Phase I(800) 545-5979

SB1578(JAK2 inhibitor)

S*BIOOakland, CA

Phase I(650) 235-5539

SCH-900776 MerckWhitehouse Station, NJ

Phase II(800) 672-6372

SMO antagonist (BMS-833923)


Phase I(800) 332-2056

SR13668 SRI InternationalMenlo Park, CA

cancer (prevention) Phase 0(650) 859-2000

V930/V932(plasmid DNA vaccine)

MerckWhitehouse Station, NJVicalSan Diego, CA

Phase I(800) 672-6372(858) 646-1100



unspeCified CanCer


VEGFR3 mAb(IMC-3C5)


Phase I(800) 545-5979

XmAb® anti-cancer mAb

Boehringer IngelheimPharmaceuticalsRidgefield, CTXencorMonrovia, CA

Phase I(800) 243-0127(626) 305-5900


The content of this report has been obtained through industry sources and the Adis “R&D Insight” database based on the latest information. Report current as of May 16, 2012. The information may not be comprehensive. For more specific information about a particular product, contact the indi-vidual company directly or go to www.clinicaltrials.gov. The entire series of Medicines in Development is available on PhRMA’s web site.

A publication of phRMA’s Communications & public Affairs Department. (202) 835-3460

www.phrma.org | www.innovation.org | www.pparx.org | www.buysafedrugs.info

Provided as a Public Service by PhRMA. Founded in 1958 as the Pharmaceutical Manufacturers Association.

Copyright © 2012 by the Pharmaceutical Research and Manufacturers of America. Permission to reprint is awarded if proper credit is given.

Pharmaceutical Research and Manufacturers of America • 950 F Street, NW, Washington, DC 20004


Glossary

actinic keratoses—Roughness and thicken-ing of the skin caused by overexposure to the sun’s ultraviolet rays. It can degenerate into a skin cancer called squamous cell carcinoma.

adenocarcinoma—Malignant tumor derived from a gland or glandular tissue.

adjunctive treatment—An auxiliary treatment that is secondary to the main treatment.

adjuvant—A substance or drug that aids another substance in its action.

allogeneic—Refers to having cell types that are distinct and cause reactions in the immune system.

application submitted—An application for marketing has been submitted by the company to the Food and Drug Administration (FDA).

ascites—Excess fluid in the space between the tissues lining the abdomen and abdominal organs (the peritoneal cavity).

basal cell cancer—Cancer of the lower layers of the skin.

B-cell—A class of white blood cells important to the body’s immune system.

biliary—Relating to bile.

carcinoma—A malignant tumor that arises from epithelial tissues, such as skin.

cervical—Relating to the neck of the uterus.

chemoprotection—A therapeutic technique in which bone marrow cells are removed from an individual with cancer and are genetically modi-fied to withstand higher doses of chemotherapy before being returned to the donor.

cholangiocarcinoma—A malignancy of the biliary duct system that may originate in the liver and extrahepatic bile ducts. More than 90 percent are adenocarcinomas, and the remain-der are squamous cell tumors. Cholangiocarci-nomas tend to grow slowly and to infiltrate the walls of the ducts. Each year, approximately 2,500 cases occur, and the average incidence is 1 case per 100,000 people per year.

cutaneous—Pertaining to the skin.

dysplasia—Abnormal tissue development.

gastric—Of or relating to the stomach.

GISt—Gastrointestinal (GI) stromal cancer is an uncommon tumor of the GI tract. Not all GISTs are cancerous; some are benign. Although these cancers can arise anywhere in the GI tract, they occur most often in the stomach (60% to 70%) and less commonly in the small intestine (20% to 30%). The rest are found in the esophagus, large intestine, rectum, and anus. About 80% of people diag-nosed with GIST are older than 50. It is slightly more common in men. Blacks are more likely to develop GISTs than whites.

glioblastoma—A fast growing and highly malignant type of brain tumor arising from glial (supporting) cells within the brain. There are about five to 10 new cases per million popula-tion per year in the United States.

glioma—A type of brain tumor arising from the supporting glial cells within the brain. Gliomas make up about 60 percent of all primary brain tumors and are frequently malignant.

graft-versus-host disease (GVHD)—A complication in bone marrow transplants where immune system cells attack the transplant recipient’s tissues.

head and neck cancer—The term given to a variety of malignant tumors that develop in the mouth, throat, paranasal sinuses, nasal cavity, larynx, and salivary glands. Many authorities also include skin tumors of the face and neck and tumors of the cervical lymph nodes. There are more than half a million survivors of oral, head, and neck cancer living in the United States today.

hematological malignancies—Cancers of the blood or blood-forming tissues, such as leuke-mia, Hodgkin’s and non-Hodgkin’s lympho-mas, AIDS-related malignancies, multiple myeloma, myelodysplasia and myeloprolifera-tive disorders.

hepatocellular cancer/carcinoma—A cancer that begins in the liver cells.

hyperuricemia—An abnormally high uric acid level in the blood.

imaging agent—A substance used to enhance x-ray images of organs and spaces in the body.

intraepithelial neoplasia, anal (AIN) & cervi-cal (CIN)—AIN is a consequence of chronic human papillomavirus infection in the anal canal and appears to be driven by high viral loads of human papillomavirus. What is known of its natural history resembles that of cervical intraepithelial neoplasia. Dysplasia and cervi-cal intraepithelial neoplasia (CIN) are different terms or names for the same condition—it is a precursor to cervical cancer. CIN may be mild, moderate or severe.

Kaposi’s sarcoma—A rare, malignant skin tumor that occurs in some AIDS patients. It can be accompanied by fever, enlarged lymph nodes and gastrointestinal problems.

Leiomyoma—A benign neoplasm derived from smooth muscle.

leukemia—A form of cancer in which abnor-mally growing white blood cells are scattered throughout the body and bone marrow. They can take over the marrow and prevent it from making enough normal blood cells (white, red and platelets), leaving the patient highly susceptible to serious infections, anemia and bleeding episodes. The cells can also spill into the blood, infiltrating and interfering with the function of other organs. The four main types of leukemia are: acute lympho blastic leuke-mia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), and chronic myeloid leukemia (CML). The acute types have a rapid onset, and overwhelming infection or blood loss can cause death. The chronic forms progress much more slowly.

lung cancer—The leading cause of cancer deaths in both men and women. There are several types of lung cancer, the most common being squamous cell carcinoma, small (oat) cell carcinoma, adenocarcinoma and large cell


Glossary

carcinoma. Each has a different growth pattern and response to treatment. The squamous cell, small cell and large cell types are all strongly associated with tobacco abuse.

lymphoma—Cancers in which the cells of lym-phoid tissue, found mainly in the lymph nodes and spleen, multiply unchecked. Lymphomas fall into two categories: Hodgkin disease, char-acterized by a particular kind of abnormal cell, and non-Hodgkin lymphomas, which vary in their malignancy according to the nature and activity of the abnormal cells. Mantle cell lym-phoma is a type of non-Hodgkin lymphoma.

macroglobulinemia—A disorder in which plasma cells produce an excessive quantity of macroglobulins (large antibodies) that ac-cumulate in the blood. It results from a group of abnormal, cancerous lymphocytes and plasma cells. Men are affected more often than women, and the average age at onset is 65.

mastocytosis—A condition characterized by infiltration of mast cells into the tissues of the body. Mast cells are connective tissue cells which release chemicals including histamine that are very irritating and cause itching, swell-ing, and fluid leakage from cells.

medullary—Relating to the medulla (any soft marrow-like structure, especially the innermost part) or marrow.

melanoma—A cancer made up of pigmented (usually brown-colored) skin cells anywhere in the body.

mesothelioma—A tumor of the lining of the lung and chest cavity (the pleura).

metastases/metastatic—Areas of secondary cancer that have spread from the primary or original cancer site.

mucositis—The swelling, irritation, and ulcer-ation of the mucosal cells that line the digestive tract. Mucositis can occur anywhere along the digestive tract from the mouth to the anus. It can be a very troublesome and painful side effect of chemotherapy.

multiple myeloma—A malignant condition of middle to old age, characterized by the uncon-trolled proliferation and disordered function of plasma cells in the bone marrow. The condi-tion, which makes the patient particularly prone to infection, is rare, with about three new cases annually per 100,000 population.

myeloablation—A severe form of myelosup-pression, a condition in which bone marrow activity is decreased, resulting in fewer red blood cells, white blood cells, and platelets. It is a side effect of some cancer treatments.

myelodysplastic syndromes (MDS)—Blood disorders that ultimately are fatal. Patients usually succumb to infections or bleeding. The term “preleukemia” has been used to describe these disorders.

neoadjuvant therapy—Chemotherapy, radia-tion therapy, or hormone therapy given before the primary or main treatment. Neo-adjuvant therapy, like chemotherapy and radiation therapy, is often given before surgery to reduce the size of a tumor or to make surgery less complicated.

neuroblastoma—A tumor of the adrenal glands or sympathetic nervous system (the part of the nervous system responsible for certain automatic body functions, such as the control of heart rate). Neuroblastomas are the most common extracranial (outside the skull) solid tumors of childhood.

osteosarcoma—Cancer of the bone that oc-curs predominantly in adolescents and young adults. It accounts for 5 percent of cancer in children.

peritoneal—Relating to the peritoneum, the membrane that lines the abdominal cavity and covers most of the abdominal organs.

phase 0—First-in-human trials conducted in accordance with FDA’s 2006 guidance on exploratory Investigational New Drug (IND) studies designed to speed up development of promising drugs by establishing very early on whether the agent behaves in human subjects as was anticipated from preclinical studies.

phase I—Safety testing and pharmacologi-cal profiling of new drugs in small numbers of humans.

phase II—Effectiveness testing and identifica-tion of side effects of new drugs in humans.

phase III—Extensive clinical trials in humans to verify effectiveness and monitor adverse reactions of new drugs.

prolactinoma—A noncancerous pituitary tumor that produces a hormone called prolac-tin, which results in too much prolactin in the blood.

refractory—Resistant to treatment or cure.

sarcoma—A malignant tumor that arises from deep body tissues, such as muscle, bone or fibrous tissue.

t-cell—One of two main classes of white blood cells called lymphocytes, which are important to the body’s disease-fighting immune system.

thrombocytopenia—A reduction in the number of platelet cells in the blood, which causes a tendency to bleed, especially from the smaller blood vessels.

thymoma—Although rare, thymomas are the most common tumor of the thymus, a small organ located in the upper chest just below the neck that produces certain types of white blood cells (lymphocytes) before birth and during childhood. Thymomas arise from thymic epithelial cells, which make up the covering of the thymus. Up to 40 percent of thymomas are invasive. They affect men and women equally and are usually diagnosed between the ages of 40 and 60. Thymomas are uncommon in children.

unresectable—Unable to be removed (re-sected) by surgery.


Selected Facts about Cancer in the United States

• Cancer is the second leading cause of death by disease—nearly 1 of every 4 deaths—in the United States, exceeded only by heart disease.

• Men have slightly less than a 1 in 2 lifetime risk of developing cancer; for women, the risk is a little more than 1 in 3. About 77 percent of all cancers are diagnosed in people ages 55 and older.

• This year alone, more than 1.6 million new cancer cases are expected to be diagnosed, and an estimated 577,190 people are expected to die of cancer. That’s more than 1,500 people a day.

• Scientific evidence suggests that about one-third of the cancer deaths expected this year will be related to overweight or obesity, physical inactiv-ity, and poor nutrition, and thus could be prevented.

• The National Cancer Institute estimates that nearly 12 million Americans with a history of cancer were alive in January 2008. The 5-year relative survival rate for all cancers diagnosed between 2001 and 2007 is 67 percent, up from 49 percent in the mid-70s.

• Studies have shown that pain occurs in 30 percent of all cancer patients, regardless of the stage of the disease, and 90 percent of patients with advanced cancer experience severe pain. Half of patients may be undertreated for cancer pain.2

• The most common cause of cancer-related pain is from metastases to the bone. Up to 80 percent of cancer patients with bone metastases experience pain. The second most common cause of cancer pain is related to tumors infiltrating the nerve and hollow viscus. Tumors near neural structures may cause the most severe pain. The third most common cause of pain associated with cancer result from chemotherapy, radiation, or surgery.2

• Breakthrough pain—pain that occurs even when taking regular pain medication—is common in cancer patients. Breakthrough cancer pain occurs in 50 percent to 90 percent of oncology inpatient settings, 89 percent of home care and inpatient hospice settings, and 35 percent of community-based oncology practices. People with breakthrough pain have a significantly higher rate of hospitalization than those without break-through pain (36.9 percent vs. 22.5 percent, respectively) and dramatically higher estimated annual costs of care ($1.7 million compared with $192,000).3

• The National Institutes of Health estimates overall costs for cancer in 2007 at $226.8 billion: $103.8 billion for direct medical costs (total of all health expenditures) and $123 billion for indirect mortality costs (cost of lost productivity due to premature death).

overview1

pain

Costs1


New Cancer Cases/Deaths1

Cancer Type Estimated 2012 New Cases Estimated 2012 Deaths

All Sites .................................................................................. 1,638,910 ..................................................................................... 577,190 Male ............................................................................. 848,170 ..................................................................................... 301,820 Female ......................................................................... 790,740 ..................................................................................... 275,370

Acute Lymphocytic Leukemia .......................................................... 6,050 ......................................................................................... 1,440 Male ................................................................................. 3,450 ............................................................................................ 820 Female ............................................................................. 2,600 ............................................................................................ 620

Acute Myeloid Leukemia ............................................................... 13,780 ....................................................................................... 10,200 Male ................................................................................. 7,350 ......................................................................................... 5,790 Female ............................................................................. 6,430 ......................................................................................... 4,410

Bladder Cancer .............................................................................. 73,510 ....................................................................................... 14,880 Male ............................................................................... 55,600 ....................................................................................... 10,510 Female ........................................................................... 17,910 ......................................................................................... 4,370

Bone Cancer (and joints) ................................................................. 2,890 ......................................................................................... 1,410 Male ................................................................................. 1,600 ............................................................................................ 790 Female ............................................................................. 1,290 ............................................................................................ 620

Brain Cancer (and other nervous system) ..................................... 22,910 ....................................................................................... 13,700 Male ............................................................................... 12,630 ......................................................................................... 7,720 Female ........................................................................... 10,280 ......................................................................................... 5,980

Breast Cancer .............................................................................. 229,060 ....................................................................................... 39,920 Male ................................................................................. 2,190 ............................................................................................ 410 Female ......................................................................... 226,870 ....................................................................................... 39,510

Cervical and Uterine Cancers ........................................................ 59,300 ....................................................................................... 12,230 Male .......................................................................................— ...............................................................................................— Female ........................................................................... 59,300 ....................................................................................... 12,230

Chronic Lymphocytic Leukemia ..................................................... 16,060 ......................................................................................... 4,580 Male ................................................................................. 9,490 ......................................................................................... 2,730 Female ............................................................................. 6,570 ......................................................................................... 1,850

Chronic Myeloid Leukemia .............................................................. 5,430 ............................................................................................ 610 Male ................................................................................. 3,210 ............................................................................................ 370 Female ............................................................................. 2,220 ............................................................................................ 240

Colorectal Cancer ........................................................................ 143,460 ....................................................................................... 51,690 Male ............................................................................... 73,420 ....................................................................................... 26,470 Female ........................................................................... 70,040 ....................................................................................... 25,220





Esophageal Cancer ....................................................................... 17,460 ....................................................................................... 15,070 Male ............................................................................... 13,950 ....................................................................................... 12,040 Female ............................................................................. 3,510 ......................................................................................... 3,030

Kidney Cancer (and renal pelvis) .................................................. 64,770 ....................................................................................... 13,570 Male ............................................................................... 40,250 ......................................................................................... 8,650 Female ........................................................................... 24,520 ......................................................................................... 4,920

Leukemia (all types) ...................................................................... 47,150 ....................................................................................... 23,540 Male ............................................................................... 26,830 ....................................................................................... 13,500 Female ........................................................................... 20,320 ....................................................................................... 10,040

Liver Cancer .................................................................................. 28,720 ....................................................................................... 20,550 Male ............................................................................... 21,370 ....................................................................................... 13,980 Female ............................................................................. 7,350 ......................................................................................... 6,570

Lung Cancer (and bronchus) ....................................................... 226,160 ..................................................................................... 160,340 Male ..............................................................................116,470 ....................................................................................... 87,750 Female ......................................................................... 109,690 ....................................................................................... 72,590

Lymphoma (all types) .................................................................... 79,190 ....................................................................................... 20,130 Male ............................................................................... 43,120 ....................................................................................... 10,990 Female ........................................................................... 36,070 ......................................................................................... 9,140

Lymphoma (non-Hodgkin’s) ........................................................... 70,130 ....................................................................................... 18,940 Male ............................................................................... 38,160 ....................................................................................... 10,320 Female ........................................................................... 31,970 ......................................................................................... 8,620

Melanoma-Skin Cancer ................................................................. 76,250 ......................................................................................... 9,180 Male ............................................................................... 44,250 ......................................................................................... 6,060 Female ........................................................................... 32,000 ......................................................................................... 3,120

Multiple Myeloma ........................................................................... 21,700 ....................................................................................... 10,710 Male ............................................................................... 12,190 ......................................................................................... 6,020 Female ............................................................................. 9,510 ......................................................................................... 4,690

Ovarian Cancer ............................................................................. 22,280 ....................................................................................... 15,500 Male .......................................................................................— ...............................................................................................— Female ........................................................................... 22,280 ....................................................................................... 15,500

Pancreatic Cancer ......................................................................... 43,920 ....................................................................................... 37,390 Male ............................................................................... 22,090 ....................................................................................... 18,850 Female ........................................................................... 21,830 ....................................................................................... 18,540

New Cancer Cases/Deaths1 continued



New Cancer Cases/Deaths1 continued

Sources:

1. Cancer Facts & Figures 2012, American Cancer Society (www.cancer.org)

2. Remedy Health Media, LLC (www.healthcommunities.com)

3. American Pain Foundation (www.painfoundation.org)


Prostate Cancer ........................................................................... 241,740 ....................................................................................... 28,170 Male ............................................................................. 241,740 ....................................................................................... 28,170 Female ...................................................................................— ...............................................................................................—

Stomach Cancer ............................................................................ 21,320 ....................................................................................... 10,540 Male ............................................................................... 13,020 ......................................................................................... 6,190 Female ............................................................................. 8,300 ......................................................................................... 4,350

the U.S. system of new drug approvals is perhaps the most rigorous in the world.It takes 10-15 years, on average, for an experimental drug to travel from lab to U.S. patients, according to the Tufts Center for the Study of Drug Development. Only five in 5,000 compounds that enter preclinical testing make it to human testing. And only one of those five is approved for sale.On average, it costs a company $1.2 billion, including the cost of failures, to get one new medicine from the laboratory to U.S. patients, according to a 2007 study by the Tufts Center for the Study of Drug Development.Once a new compound has been identified in the laboratory, medicines are usually devel-oped as follows:preclinical testing. A pharmaceutical com-pany conducts laboratory and animal studies to show biological activity of the compound against the targeted disease, and the com-pound is evaluated for safety.Investigational New Drug Application (IND). After completing preclinical testing, a company files an IND with the U.S. Food and Drug

Administration (FDA) to begin to test the drug in people. The IND shows results of previous experiments; how, where and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in the animal studies; and how the compound is manufactured. All clinical trials must be reviewed and approved by the Institutional Review Board (IRB) where the trials will be conducted. Progress reports on clinical trials must be submitted at least annually to FDA and the IRB.Clinical trials, phase I. These tests usually involve about 20 to 100 healthy volunteers. The tests study a drug’s safety profile, including the safe dosage range. The studies also determine how a drug is absorbed, distributed, metabo-lized, and excreted as well as the duration of its action.Clinical trials, phase II. In this phase, controlled trials of approximately 100 to 500 volunteer patients (people with the disease) assess a drug’s effectiveness and determine the early side effect profile.Clinical trials, phase III. This phase usually involves 1,000 to 5,000 patients in clinics and

hospitals. Physicians monitor patients closely to confirm efficacy and identify adverse events. New Drug Application (NDA)/Biologic License Application (BLA). Following the completion of all three phases of clinical trials, a company analyzes all of the data and files an NDA or BLA with FDA if the data successfully demonstrate both safety and effectiveness. The applications contain all of the scientific information that the company has gathered. Applications typically run 100,000 pages or more.Approval. Once FDA approves an NDA or BLA, the new medicine becomes available for physicians to prescribe. A company must continue to submit periodic reports to FDA, including any cases of adverse reactions and appropriate quality-control records. For some medicines, FDA requires additional trials (Phase IV) to evaluate long-term effects. Discovering and developing safe and effective new medicines is a long, difficult, and expensive process. PhRMA member companies invested an estimated $49.5 billion in research and development in 2011.

The Drug Discovery, Development and Approval Process

Developing a new medicine takes an average of 10-15 years; For every 5,000-10,000 compounds in the pipeline, only 1 is approved.

The Drug Development and Approval Process

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PhRMA Report 2012: Medicines in Development for Cancer

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